WO2022071656A1 - Dispositif d'injection de médicament - Google Patents

Dispositif d'injection de médicament Download PDF

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Publication number
WO2022071656A1
WO2022071656A1 PCT/KR2021/010625 KR2021010625W WO2022071656A1 WO 2022071656 A1 WO2022071656 A1 WO 2022071656A1 KR 2021010625 W KR2021010625 W KR 2021010625W WO 2022071656 A1 WO2022071656 A1 WO 2022071656A1
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WO
WIPO (PCT)
Prior art keywords
thin film
magnetic thin
drug
injection device
magnetic
Prior art date
Application number
PCT/KR2021/010625
Other languages
English (en)
Korean (ko)
Inventor
박성민
김강욱
Original Assignee
큐어스트림(주)
포항공과대학교 산학협력단
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 큐어스트림(주), 포항공과대학교 산학협력단 filed Critical 큐어스트림(주)
Publication of WO2022071656A1 publication Critical patent/WO2022071656A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/14244—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body
    • A61M5/14248—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body of the skin patch type
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/14212—Pumping with an aspiration and an expulsion action
    • A61M5/14224—Diaphragm type
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/14244—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body
    • A61M2005/14268—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body with a reusable and a disposable component
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
    • A61M2005/14506—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons mechanically driven, e.g. spring or clockwork
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/82—Internal energy supply devices
    • A61M2205/8275—Mechanical
    • A61M2205/8287—Mechanical operated by an external magnetic or electromagnetic field

Definitions

  • This application relates to a drug injection device, and more specifically, by using a magnetic thin film pump, a drug can be injected into the body through a relatively small and simple structure, and in particular, the pump function is further improved through a patterned magnetic thin film to It relates to a drug injection device capable of more precisely controlling the injection amount.
  • a drug injection device for injecting drugs such as hormones into the human body is widely used for the treatment of various diseases.
  • diabetes mellitus is a type of metabolic disease, such as insufficient insulin secretion or normal function, and is characterized by a high blood glucose concentration.
  • a treatment method for diabetes there are diet, exercise, drug therapy, insulin injection, and the like, and recently, a method using an artificial pancreas is being developed.
  • the artificial pancreas is spotlighted as an alternative means to overcome the limitations of existing treatment methods for diabetic patients who have to depend on insulin. and is configured to control the hormone (insulin) pump/patch using the values measured in the CGM by the control algorithm.
  • the hormone (insulin) pump is a kind of drug injection device for supplying insulin to the bloodstream of a patient, also called an insulin syringe, an insulin auto-injector, and the like, and is configured to inject insulin by a mechanical means such as a motor.
  • an embodiment of the present invention provides a drug injection device.
  • the drug injection device a rechargeable module for supplying a magnetic field; and a disposable module comprising a magnetic thin film pump having a magnetic thin film patterned according to a predetermined pattern of magnetic material or polarity, wherein the magnetic thin film is deflected by a magnetic field supplied by the rechargeable module through a pumping action It is characterized by injecting the drug into the body.
  • a drug injection device capable of injecting a drug in a form attachable to the human body by utilizing magnetic force without mechanical means such as a motor.
  • the flexibility and elasticity of the magnetic thin film are further optimized to provide a drug injection device capable of more precisely controlling the injection amount of a drug can do.
  • the rechargeable module and the disposable module are modularized so that they can be detached from each other, so that it can be mass-produced at a low cost, and the disposable module for injecting the drug is used for one-time use, and an expensive circuit board and By allowing the battery to be reused, it is possible to provide a drug injection device that secures both safety and economy.
  • FIG. 1 is a block diagram of a drug injection device according to an embodiment of the present invention.
  • FIG. 2 is a schematic diagram for explaining the detailed configuration and operation of the magnetic thin film pump according to an embodiment of the present invention.
  • FIG 3 is a view showing an embodiment of a magnetic thin film pump according to an embodiment of the present invention.
  • FIG. 4 is a diagram illustrating various embodiments of a patterned magnetic thin film according to an embodiment of the present invention.
  • FIG. 5 is a diagram illustrating a cross-section of a patterned magnetic thin film according to an embodiment of the present invention.
  • FIG. 6 is a diagram illustrating an embodiment of a drug injection device according to an embodiment of the present invention.
  • FIG. 7 is a diagram illustrating an embodiment in which the drug injection device shown in FIG. 6 is expanded to a heterogeneous drug injection device.
  • control unit 1120 control unit
  • FIG. 1 is a block diagram of a drug injection device according to an embodiment of the present invention.
  • a drug injection device 1000 may be largely divided into a rechargeable module 1100 and a disposable module 1200 .
  • the rechargeable module 1100 is for supplying a magnetic field for operation of the drug injection device 1000, and may include a power supply unit 1110, a control unit 1120, a magnetic field supply unit 1130, and a housing 1140. .
  • the power supply unit 1110 supplies power for generating a magnetic field, and may be implemented as a rechargeable battery such as, for example, a lithium polymer (LiPo) battery.
  • a rechargeable battery such as, for example, a lithium polymer (LiPo) battery.
  • the control unit 1120 is for controlling the operation of the rechargeable module 1100 to control the injection of drugs, and according to an example, a magnetic thin film to be described later by controlling the magnetic field supplied by the magnetic field supply unit 1130 according to an external input signal.
  • the amount of the drug injected by the pump 1210 can be precisely controlled.
  • the magnetic field supply unit 1130 is for supplying a magnetic field under the control of the controller 1120 , and according to an example, may include an integrated circuit-based electromagnetic induction coil.
  • the electromagnetic induction coil may be manufactured through a MEMS process or implemented as a coil-patterned printed circuit board.
  • the housing 1140 is to protect the internal components of the rechargeable module 1100. According to an example, it is formed in a streamlined shape using a flexible material to minimize external resistance and contact to minimize deformation from living pressure. can do.
  • the disposable module 1200 is for injecting a drug into the body by the magnetic field supplied by the rechargeable module 1100, the magnetic thin film pump 1210, the chamber 1220, the patch 1230 and the cannula (1240) It may be composed of
  • the magnetic thin film pump 1210 is for injecting the drug accommodated in the chamber 1220 into the body.
  • Figure 2 is a schematic diagram for explaining the detailed configuration and operation of the magnetic thin film pump according to an embodiment of the present invention
  • Figure 3 is a view showing an embodiment of the magnetic thin film pump according to an embodiment of the present invention.
  • the magnetic thin film pump 1210 has an inlet for injecting the drug 10 into the pump chamber 1213 formed inside the magnetic thin film pump 1210 ( 1211), and a pump chamber 1213 for accommodating the drug 10, and an outlet 1212 for discharging the drug 10 to the outside from the pump chamber 1213 may be provided.
  • the inlet 1211 and the outlet 1212 may be additionally provided with a check valve 1215 for preventing the reverse flow of the drug.
  • a magnetic thin film 1214 is provided on one surface of the pump chamber 1213, and the magnetic thin film 1214 is directed toward the pump chamber 1213 by the magnetic field supplied by the above-described magnetic field supply unit 1130 (or the pump chamber ( 1213) and away from it) (1214' in (b) of FIG. 2).
  • the magnetic thin film 1214 is deflected in the direction away from the pump chamber 1213 or the pump chamber 1213 by the magnetic field induced by the electromagnetic induction coil included in the magnetic field supply unit 1130, and accordingly, the pump chamber 1213 )
  • the drug 10 accommodated in it may be discharged through the outlet 1212 and injected into the body.
  • the strength of the magnetic field may be varied by the amount of current selectively flowing to the electromagnetic induction coil, and the amount of the drug injected into the body may be controlled according to the varying strength of the magnetic field. As such, it is possible to precisely control the amount of drug injected into the body by varying the strength of the magnetic field.
  • the magnetic thin film 1214 acts as a membrane covering one surface of the pump chamber 1213 and responds to the magnetic field. It can be deflected by the to act as a driving unit for discharging the drug at the same time. Accordingly, it is possible to implement a drug injection device that can operate only with a simpler structure.
  • the magnetic thin film 1214 may be formed by magnetizing the N pole and the S pole to form a preset pattern.
  • the magnetic thin film 1214 may be magnetized in a radial direction. That is, the center of the magnetic thin film 1214 formed in a disk shape and the edge region of the magnetic thin foil 1214 may have different polarities.
  • the central portion of the magnetic thin film 1214 has an N pole and an edge region has an S pole, but the present invention is not limited thereto, and the positions of the polarities may be changed.
  • the magnetic thin film 1214 magnetized in the radial direction as described above since the central portion has one polarity, there is no unnecessary torque generation. The advantage is that it can act in a direction that helps the movement of the magnetic thin film.
  • the magnetic thin film pump 1210 may be configured to have magnetic thin films 1214 and 1214' on both sides (ie, upper and lower portions of the pump chamber 1213), respectively.
  • each of the magnetic thin films 1214 and 1214' may be magnetized in the radial direction, and at the same time, the upper and lower surfaces, which are both sides of each of the magnetic thin films 1214 and 1214', may have different polarities. .
  • FIG. 4 is a view showing various embodiments of a patterned magnetic thin film according to an embodiment of the present invention
  • FIG. 5 is a view showing a cross section of the patterned magnetic thin film according to an embodiment of the present invention.
  • the magnetic thin film 1214 is that the magnetic material 1214-2 is applied to the entire surface of the membrane (eg, the silicon thin film 1214-1) covering one surface of the pump chamber 1213 .
  • the magnetic material 1214 - 2 may be applied to a portion of the membrane in a patterned form according to a preset pattern.
  • a magnetic material 1214 - 2 is located at a portion where the magnetic thin film 1214 is connected to the outer side of the pump chamber 1213 , that is, an edge region of the magnetic thin film 1214 . ) is not applied, and the magnetic material 1214 - 2 may be applied only to a predetermined area from the center of the magnetic thin film 1214 .
  • a band made of the magnetic material 1214 - 2 from the center of the magnetic thin film 1214 may be formed to form a concentric pattern.
  • a band made of a magnetic material 1214-2 from the center of the magnetic thin film 1214 forms a concentric circle pattern, and the center of the magnetic thin film 1214 has a permanent magnet ( 1214-3) may be placed.
  • one or more supports 1214-4 passing through the center of the magnetic thin film 1214 in the pattern shown in (b) and (c) are additionally added. can also be formed.
  • the support 1214 - 4 may be patterned with a magnetic material 1214 - 2 or may be formed of a material having a piezoelectric property.
  • the patterned magnetic thin film 1214 may be formed using a pre-fabricated mold with a preset pattern.
  • the patterned magnetic thin film 1214 as described above can more optimize flexibility and elasticity compared to the magnetic thin film in which the entire surface of the silicon thin film 1214-1 constituting the membrane is coated with a magnetic material, and thus It is possible to control the injection amount more precisely.
  • the chamber 1220 is for accommodating a drug to be injected into the body, and the drug accommodated in the chamber 1220 may be supplied to the magnetic thin film pump 1210 .
  • the patch 1230 is for bonding the drug injection device 1000 to the human body, and may be made of, for example, a soft and stretchable material such as silicone in consideration of the user's wearing comfort and safety.
  • one surface of the patch 1230 is adhered to the human body, and the magnetic thin film pump 1210 , the chamber 1220 , and the cannula 1240 may be attached to the other surface.
  • the cannula 1240 is for injecting the drug discharged through the outlet 1212 of the magnetic thin film pump 1210 into the body.
  • FIG. 6 is a diagram illustrating an embodiment of a drug injection device having a patterned magnetic thin film according to an embodiment of the present invention
  • FIG. 7 is a heterogeneous drug injection device using the drug injection device shown in FIG. It is a drawing showing one implementation to expand.
  • the rechargeable module 1100 and the disposable module 1200 are modularized to be detachable from each other, so that they can be mass-produced at a low cost and the disposable module 1200 for injecting the drug is used for one-time use. , an expensive circuit board and battery can be reused to realize a drug injection device that secures both safety and economy.
  • the magnetic thin film pump, the battery, and the chamber are integrated without an external connection, it is possible to reduce the weight and size, thereby minimizing user inconvenience.

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  • Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Dermatology (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

Un dispositif d'injection de médicament selon un mode de réalisation de la présente invention comprend : un module rechargeable servant à fournir un champ magnétique ; et un module jetable comprenant une pompe à film mince magnétique ayant un film mince magnétique dans lequel un matériau magnétique ou une polarité est modelée selon un motif prédéterminé. Le dispositif injecte un médicament dans un corps par l'intermédiaire d'une action de pompage dans laquelle le film mince magnétique est dévié par le champ magnétique fourni par le module rechargeable.
PCT/KR2021/010625 2020-09-29 2021-08-11 Dispositif d'injection de médicament WO2022071656A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1020200126519A KR102538410B1 (ko) 2020-09-29 2020-09-29 약물 주입 기기
KR10-2020-0126519 2020-09-29

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WO2022071656A1 true WO2022071656A1 (fr) 2022-04-07

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WO (1) WO2022071656A1 (fr)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20240009686A (ko) * 2022-07-14 2024-01-23 큐어스트림(주) 멤브레인 펌프 및 그 멤브레인 펌프를 구비한 약물 주입장치
KR102654361B1 (ko) 2023-10-04 2024-04-03 큐어스트림(주) 피스톤 체크밸브 모듈을 갖는 약액 주입 장치

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20070061170A (ko) * 2005-12-08 2007-06-13 한국전자통신연구원 전자기 액츄에이터를 이용한 펌프
KR20150110244A (ko) * 2014-03-21 2015-10-02 (주)엠플러스 다극자화를 통한 패턴화된 극성을 갖는 자석부착모듈 및 이를 이용한 전자기기 케이스
KR20190122397A (ko) * 2018-04-20 2019-10-30 경상대학교산학협력단 마이크로젯 약물 전달 시스템
US20190338230A1 (en) * 2018-05-01 2019-11-07 Massachusetts Institute Of Technology Pumps and hardware for organ-on-chip platforms
KR20200026355A (ko) * 2018-08-29 2020-03-11 서강대학교산학협력단 초박형 약액 펌프

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2022518A1 (fr) 2007-08-07 2009-02-11 Sensile Pat AG Dispositif modulaire pour l'administration de doses divisées d'un médicament

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20070061170A (ko) * 2005-12-08 2007-06-13 한국전자통신연구원 전자기 액츄에이터를 이용한 펌프
KR20150110244A (ko) * 2014-03-21 2015-10-02 (주)엠플러스 다극자화를 통한 패턴화된 극성을 갖는 자석부착모듈 및 이를 이용한 전자기기 케이스
KR20190122397A (ko) * 2018-04-20 2019-10-30 경상대학교산학협력단 마이크로젯 약물 전달 시스템
US20190338230A1 (en) * 2018-05-01 2019-11-07 Massachusetts Institute Of Technology Pumps and hardware for organ-on-chip platforms
KR20200026355A (ko) * 2018-08-29 2020-03-11 서강대학교산학협력단 초박형 약액 펌프

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KR20220043291A (ko) 2022-04-05
KR102538410B1 (ko) 2023-06-01

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