WO2022063857A1 - Composition for promoting the skin microbiome - Google Patents
Composition for promoting the skin microbiome Download PDFInfo
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- WO2022063857A1 WO2022063857A1 PCT/EP2021/076117 EP2021076117W WO2022063857A1 WO 2022063857 A1 WO2022063857 A1 WO 2022063857A1 EP 2021076117 W EP2021076117 W EP 2021076117W WO 2022063857 A1 WO2022063857 A1 WO 2022063857A1
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- caprylic
- source
- capric triglycerides
- skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
- A61K8/375—Esters of carboxylic acids the alcohol moiety containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/42—Amides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
Definitions
- the present invention generally relates to the field of skin care. More particularly, the invention relates to a skin care composition that comprises growth-enhancing compounds which promote the development of a healthy skin microbiome. These growth-enhancing compounds are metabolized by the microorganisms of the skin microbiome after their topical application to the skin, thereby supporting growth of the microorganisms.
- the growthenhancing compounds and compositions comprising same can be used for treating or preventing skin diseases, for promoting the development of a healthy skin microbiome, for stabilizing a healthy skin microbiome, and for promoting growth of bacteria of the skin microbiome.
- the human skin is colonized by millions of microorganisms, in particular bacteria and fungi. Most of these microorganisms are harmless or even beneficial to their host.
- the entirety of the microorganisms living on the human skin is referred to as the "skin microbiome".
- the skin microbiome has a direct influence on human health. For example, bacteria of the skin microbiome contribute to health by secreting antimicrobial compounds that provide a barrier to infection of the body with pathogenic bacteria or fungi.
- the skin microbiome interacts with the immune system and effectively stimulates the immune system to combat pathogenic bacteria and fungi.
- the human skin is a habitat that is generally unfavorable for microorganisms.
- the skin is salty, dry and continuously exposed to UV radiation.
- the availability of nutrients on the skin surface is limited to compounds that are released from dead skin cells of the upper epidermal layer. Due to these harsh conditions, the overall number of bacterial and fungal cells on skin is rather low, especially in dry areas such as the forearm, leg and lower back.
- Daily washing the skin with soap as well as the use of inappropiate cosmetic products provide additional antimicrobial effects which further reduce the overall number of bacterial and fungal cells on skin and may result in a disturbance of the skin microbiome.
- a healthy microbiome there appears to be a balance of the resident microorganisms with respect to each other.
- a disturbance of said balance is thought to contribute to diseases or disorders, such as acne or eczema.
- the number of bacteria from the resident flora such as Staphylococcus epidermidis
- pathogenic or potentially pathogenic bacteria such as Staphylococcus aureus.
- a healthy and stable microbiome normally prevents the colonization of the skin with such pathogenic or potentially pathogenic bacteria. Accordingly, there is a need for means and methods that result in the maintainance of a healthy skin microbiome. In addition, there is a need for means and methods that could promote growth of the resident microorganisms in the microbiome.
- a skin care composition that comprises a high amount of compounds which can be metabolized by the microorganisms of the skin microbiome, thereby promoting their growth.
- certain compounds upon their topical application to the skin, can be used as carbon, nitrogen, or lipid source by the microorganisms of the skin microbiome. The topical application of such compounds therefore provides improved metabolic conditions for these microorganisms on the skin surface.
- the growth-enhancing compounds disclosed herein are metabolized by the resident microorganisms, i.e. the microorganisms that normally occur as part of the human skin microbiome, much more effective compared to transient microorganisms which colonize the skin only temporarily, e.g. after touching contaminated objects with the hands.
- the compounds disclosed herein provide a growth advantage to resident microorganisms, such as S. epidermidis, over pathogenic microorganisms like S. aureus. In this way, these compounds assist in stabilizing and promoting growth of the resident microorganisms of the skin microbiome.
- the present invention relates to a skin care composition for promoting the skin microbiome, wherein said composition is formulated for topical application to the skin and comprises
- a carbon source selected from the group consisting of glucose, fructose, saccharose, maltose, maltodextrin, pyruvic acid, pyruvate, lactic acid and/or lactate.
- the skin care composition of the present invention further comprises at least one of following components:
- a nitrogen source selected from the group of alanine, glycine, arginine and/or urea;
- the invention relates to a composition for promoting the skin microbiome which comprises a carbon source, which either is glucose, fructose, saccharose, maltose, maltodextrin, pyruvic acid, pyruvate, lactic acid, lactate or a combination of any of theses, and at least one additional growth-enhancing compound.
- the additional growth-enhancing compound can be a nitrogen source selected from urea, alanine, glycine and arginine or caprylic/capric triglycerides as a lipid source.
- the composition of the invention comprises all three types of components. Accordingly, in a preferred aspect, the invention relates to a skin care composition for promoting the skin microbiome, wherein said composition is formulated for topical application to the skin and comprises
- the present invention relates to a skin care composition for promoting the skin microbiome, wherein said composition is formulated for topical application to the skin and comprises
- the skin care composition of the present invention further comprises at least one of following components:
- the invention also relates to a composition for promoting the skin microbiome which comprises a carbon source, which either is pyruvic acid, pyruvate, lactic acid, lactate or mixtures thereof, e.g. a combination of pyruvate and lactate, and at least one additional growthenhancing compound.
- the additional growth-enhancing compound can be a nitrogen source selected from urea and arginine or caprylic/capric triglycerides as a lipid source.
- the composition of the invention comprises all three types of components. Accordingly, in a preferred aspect, the invention relates to a skin care composition for promoting the skin microbiome, wherein said composition is formulated for topical application to the skin and comprises
- the invention relates to a skin care composition for promoting the skin microbiome, wherein said composition is formulated for topical application to the skin and comprises
- (c) optionally, caprylic/capric triglycerides as a lipid source.
- the composition of the invention comprises pyruvic acid, pyruvate or mixtures thereof as a carbon source. If pyruvic acid is used, it will normally dissociate to some extent in aqueous solution. Therefore, it will be present in an aqueous environment as a mixture of undissociated pyruvic acid and the corresponding salt pyruvate. As shown in the below examples, pyruvic acid and pyruvate are able to significantly increase the cell number of the resident bacteria when applied in the form of a skin care composition to the facial skin. As used herein, pyruvate refers to a salt or ester of 2- oxopropanoic acid. Preferably, the pyruvate in the composition is calcium or sodium pyruvate. Sodium pyruvate is used in some cosmetic compositions for stimulating collagen synthesis.
- a preferred skin care composition of the invention comprises the following:
- caprylic/capric triglycerides as a lipid source.
- the pyruvic acid, pyruvate or the mixture of both components is present in the composition in an amount of 0.05 to 5.0% (w/w), more preferably 0.1 to 5.0% (w/w), more preferably 0.2 to 4.5% (w/w), more preferably 0.3 to 4.0% (w/w), more preferably 0.4 to 3.5% (w/w), more preferably 0.5 to 3.0% (w/w), more preferably 0.6 to 2.5% (w/w), more preferably 0.7 to 2.0% (w/w), more preferably 0.8 to 1.5% (w/w), such as 1.0% (w/w).
- An amount of 0.05 to 1.0% (w/w) is particularly preferred.
- the amount of pyruvic acid, pyruvate or mixtures thereof present in the composition is at least 0.3 (w/w), at least 0.4 (w/w), at least 0.5 (w/w), at least 0.6 (w/w), at least 0.7 (w/w), at least 0.8 (w/w), at least 0.9 (w/w), at least 1.0 (w/w), at least 2.0 (w/w), or at least 3.0 (w/w). All weight percentages mentioned herein in relation to certain components refer, unless stated otherwise, to the total weight of the preparation or composition.
- the urea is present in the composition in an amount of 0.05 to 5.0% (w/w), more preferably 0.1 to 5.0% (w/w), more preferably 0.2 to 4.5% (w/w), more preferably 0.3 to 4.0% (w/w), more preferably 0.4 to 3.5% (w/w), more preferably 0.5 to 3.0% (w/w), more preferably 0.6 to 2.5% (w/w), more preferably 0.7 to 2.0% (w/w), more preferably 0.8 to 1.5% (w/w), such as 1.0% (w/w).
- the amount of urea present in the composition is at least 0.3 (w/w), at least 0.4 (w/w), at least 0.5 (w/w), at least 0.6 (w/w), at least 0.7 (w/w), at least 0.8 (w/w), at least 0.9 (w/w), at least 1.0 (w/w), at least 2.0 (w/w), or at least 3.0 (w/w).
- composition may optionally include caprylic/capric triglycerides as a lipid source.
- caprylic/capric triglycerides refers to triglycerides in which the glycerol is esterified with the fatty acids caprylic acid and capric acid.
- the caprylic/capric triglycerides are preferably present in an amount of 0.1 to 6.0% (w/w), more preferably 0.2 to 6.0% (w/w), more preferably 0.3 to 5.5% (w/w), more preferably 0.4 to 5.0% (w/w), more preferably 0.5 to 4.5% (w/w), more preferably 0.6 to 4.0% (w/w), more preferably 0.7 to 3.5% (w/w), more preferably 0.8 to 3.0% (w/w), more preferably 0.9 to 2.5% (w/w), more preferably 1.0 to 3.0% (w/w), more preferably 1.5 to 2.5% (w/w), such as 2.0% (w/w).
- the amount of caprylic/capric triglycerides present in the composition is at least 0.3 (w/w), at least 0.4 (w/w), at least 0.5 (w/w), at least 0.6 (w/w), at least 0.7 (w/w), at least 0.8 (w/w), at least 0.9 (w/w), at least 1.0 (w/w), at least 2.0 (w/w), at least 3.0 (w/w), at least 4.0 (w/w), or at least 5.0 (w/w).
- Another preferred skin care composition of the invention comprises the following:
- caprylic/capric triglycerides as a lipid source.
- the pyruvic acid, pyruvate or the mixtures of both components is preferably present in the composition in an amount as outlined above.
- the arginine is preferably present in the composition in an amount of 0.05 to 5.0% (w/w), more preferably 0.1 to 5.0% (w/w), more preferably 0.2 to 4.5% (w/w), more preferably 0.3 to 4.0% (w/w), more preferably 0.4 to 3.5% (w/w), more preferably 0.5 to 3.0% (w/w), more preferably 0.6 to 2.5% (w/w), more preferably 0.8 to 2.0% (w/w), more preferably 0.9 to 1.5% (w/w), such as 1.0% (w/w).
- the amount of arginine present in the composition is at least 0.3 (w/w), at least 0.4 (w/w), at least 0.5 (w/w), at least 0.6 (w/w), at least 0.7 (w/w), at least 0.8 (w/w), at least 0.9 (w/w), at least 1.0 (w/w), at least 2.0 (w/w), or at least 3.0 (w/w).
- This composition may op- tionally include caprylic/capric triglycerides as a lipid source. If present, the caprylic/capric triglycerides are preferably used in the amounts outlines above.
- Another preferred skin care composition of the invention comprises the following:
- caprylic/capric triglycerides as a lipid source.
- the pyruvic acid, pyruvate or the mixture of both components is preferably present in the composition in an amount as outlined above.
- the glycine is preferably present in the composition in an amount of 0.05 to 5.0% (w/w), more preferably 0.1 to 5.0% (w/w), more preferably 0.2 to 4.5% (w/w), more preferably 0.3 to 4.0% (w/w), more preferably 0.4 to 3.5% (w/w), more preferably 0.5 to 3.0% (w/w), more preferably 0.6 to 2.5% (w/w), more preferably 0.8 to 2.0% (w/w), more preferably 0.9 to 1.5% (w/w), such as 1.0% (w/w).
- the amount of glycine present in the composition is at least 0.3 (w/w), at least 0.4 (w/w), at least 0.5 (w/w), at least 0.6 (w/w), at least 0.7 (w/w), at least 0.8 (w/w), at least 0.9 (w/w), at least 1.0 (w/w), at least 2.0 (w/w), or at least 3.0 (w/w).
- This composition may optionally include caprylic/capric triglycerides as a lipid source. If present, the caprylic/capric triglycerides are preferably used in the amounts outlines above.
- Another preferred skin care composition of the invention comprises the following:
- caprylic/capric triglycerides as a lipid source.
- the pyruvic acid, pyruvate or the mixture of both components is preferably present in the composition in an amount as outlined above.
- the alanine is preferably present in the composition in an amount of 0.05 to 5.0% (w/w), more preferably 0.1 to 5.0% (w/w), more preferably 0.2 to 4.5% (w/w), more preferably 0.3 to 4.0% (w/w), more preferably 0.4 to 3.5% (w/w), more preferably 0.5 to 3.0% (w/w), more preferably 0.6 to 2.5% (w/w), more preferably 0.8 to 2.0% (w/w), more preferably 0.9 to 1.5% (w/w), such as 1.0% (w/w).
- the amount of alanine present in the composition is at least 0.3 (w/w), at least 0.4 (w/w), at least 0.5 (w/w), at least 0.6 (w/w), at least 0.7 (w/w), at least 0.8 (w/w), at least 0.9 (w/w), at least 1.0 (w/w), at least 2.0 (w/w), or at least 3.0 (w/w).
- This composition may optionally include caprylic/capric triglycerides as a lipid source. If present, the caprylic/capric triglycerides are preferably used in the amounts outlines above.
- the composition of the invention comprises lactic acid, lactate or mixtures thereof as a carbon source.
- lactate refers to a salt or ester of lactic acid. If lactic acid is used, it will normally dissociate to some extent in aqueous solution. Therefore, it will be present in an aqueous environment as a mixture of undissociated lactic acid and the corresponding salt lactate.
- the lactate in the composition is calcium or sodium lactate.
- Sodium lactate is used as a humectant in some cosmetic compositions as well as for pH stabilization.
- Preferred skin care compositions of the invention that comprise lactate as a growth-enhancing component include:
- a preferred skin care composition of the invention comprises the following:
- capryl ic/capric triglycerides as a lipid source.
- the lactic acid, lactate or the mixture of both components is present in the composition in an amount of 0.05 to 5.0% (w/w), more preferably 0.1 to 5.0% (w/w), more preferably 0.2 to 4.5% (w/w), more preferably 0.3 to 4.0% (w/w), more preferably 0.4 to 3.5% (w/w), more preferably 0.5 to 3.0% (w/w), more preferably 0.6 to 2.5% (w/w), more preferably 0.7 to 2.0% (w/w), more preferably 0.8 to 1.5% (w/w), such as 1.0% (w/w).
- the amount of lactic acid, lactate or the mixture of both components present in the composition is at least 0.3 (w/w), at least 0.4 (w/w), at least 0.5 (w/w), at least 0.6 (w/w), at least 0.7 (w/w), at least 0.8 (w/w), at least 0.9 (w/w), at least 1.0 (w/w), at least 2.0 (w/w), or at least 3.0 (w/w).
- the urea is present in the composition in an amount of 0.05 to 5.0% (w/w), more preferably 0.1 to 5.0% (w/w), more preferably 0.2 to 4.5% (w/w), more preferably 0.3 to 4.0% (w/w), more preferably 0.4 to 3.5% (w/w), more preferably 0.5 to 3.0% (w/w), more preferably 0.6 to 2.5% (w/w), more preferably 0.7 to 2.0% (w/w), more preferably 0.8 to 1.5% (w/w), such as 1.0% (w/w).
- the amount of urea present in the composition is at least 0.3 (w/w), at least 0.4 (w/w), at least 0.5 (w/w), at least 0.6 (w/w), at least 0.7 (w/w), at least 0.8 (w/w), at least 0.9 (w/w), at least 1.0 (w/w), at least 2.0 (w/w), or at least 3.0 (w/w).
- This composition may optionally include caprylic/capric triglycerides as a lipid source.
- the caprylic/capric triglycerides are preferably present in an amount of 0.1 to 6.0% (w/w), more preferably 0.2 to 6.0% (w/w), more preferably 0.3 to 5.5% (w/w), more preferably 0.4 to 5.0% (w/w), more preferably 0.5 to 4.5% (w/w), more preferably 0.6 to 4.0% (w/w), more preferably 0.7 to 3.5% (w/w), more preferably 0.8 to 3.0% (w/w), more preferably 0.9 to 2.5% (w/w), more preferably 1.0 to 3.0% (w/w), more preferably 1.5 to 2.5% (w/w), such as 2.0% (w/w).
- the amount of caprylic/capric triglycerides present in the composition is at least 0.3 (w/w), at least 0.4 (w/w), at least 0.5 (w/w), at least 0.6 (w/w), at least 0.7 (w/w), at least 0.8 (w/w), at least 0.9 (w/w), at least 1.0 (w/w), at least 2.0 (w/w), at least 3.0 (w/w), at least 4.0 (w/w), or at least 5.0 (w/w).
- Another preferred skin care composition of the invention comprises the following:
- caprylic/capric triglycerides as a lipid source.
- the lactic acid, lactate, or the mixture of both components is preferably present in the composition in an amount as outlined above.
- the arginine is preferably present in the composition in an amount of 0.05 to 5.0% (w/w), more preferably 0.1 to 5.0% (w/w), more preferably 0.2 to 4.5% (w/w), more preferably 0.3 to 4.0% (w/w), more preferably 0.4 to 3.5% (w/w), more preferably 0.5 to 3.0% (w/w), more preferably 0.6 to 2.5% (w/w), more preferably 0.8 to 2.0% (w/w), more preferably 0.9 to 1.5% (w/w), such as 1.0% (w/w).
- the amount of arginine present in the composition is at least 0.3 (w/w), at least 0.4 (w/w), at least 0.5 (w/w), at least 0.6 (w/w), at least 0.7 (w/w), at least 0.8 (w/w), at least 0.9 (w/w), at least 1.0 (w/w), at least 2.0 (w/w), or at least 3.0 (w/w).
- This composition may optionally include caprylic/capric triglycerides as a lipid source. If present, the caprylic/capric triglycerides are preferably used in the amounts outlines above.
- Another preferred skin care composition of the invention comprises the following:
- caprylic/capric triglycerides as a lipid source.
- the lactic acid, lactate, or the mixture of both components is preferably present in the composition in an amount as outlined above.
- the glycine is preferably present in the composition in an amount of 0.05 to 5.0% (w/w), more preferably 0.1 to 5.0% (w/w), more preferably 0.2 to 4.5% (w/w), more preferably 0.3 to 4.0% (w/w), more preferably 0.4 to 3.5% (w/w), more preferably 0.5 to 3.0% (w/w), more preferably 0.6 to 2.5% (w/w), more preferably 0.8 to 2.0% (w/w), more preferably 0.9 to 1.5% (w/w), such as 1.0% (w/w).
- the amount of glycine present in the composition is at least 0.3 (w/w), at least 0.4 (w/w), at least 0.5 (w/w), at least 0.6 (w/w), at least 0.7 (w/w), at least 0.8 (w/w), at least 0.9 (w/w), at least 1.0 (w/w), at least 2.0 (w/w), or at least 3.0 (w/w).
- This composition may optionally include caprylic/capric triglycerides as a lipid source. If present, the caprylic/capric triglycerides are preferably used in the amounts outlines above.
- Another preferred skin care composition of the invention comprises the following:
- caprylic/capric triglycerides as a lipid source.
- the lactic acid, lactate, or the mixture of both components is preferably present in the composition in an amount as outlined above.
- the alanine is preferably present in the composition in an amount of 0.05 to 5.0% (w/w), more preferably 0.1 to 5.0% (w/w), more preferably 0.2 to 4.5% (w/w), more preferably 0.3 to 4.0% (w/w), more preferably 0.4 to 3.5% (w/w), more preferably 0.5 to 3.0% (w/w), more preferably 0.6 to 2.5% (w/w), more preferably 0.8 to 2.0% (w/w), more preferably 0.9 to 1.5% (w/w), such as 1.0% (w/w).
- the amount of alanine present in the composition is at least 0.3 (w/w), at least 0.4 (w/w), at least 0.5 (w/w), at least 0.6 (w/w), at least 0.7 (w/w), at least 0.8 (w/w), at least 0.9 (w/w), at least 1.0 (w/w), at least 2.0 (w/w), or at least 3.0 (w/w).
- This composition may optionally include caprylic/capric triglycerides as a lipid source. If present, the caprylic/capric triglycerides are preferably used in the amounts outlines above.
- Another preferred skin care composition of the invention comprises the following:
- caprylic/capric triglycerides as a lipid source.
- the glucose is present in the composition in an amount of 0.05 to 5.0% (w/w), more preferably 0.1 to 5.0% (w/w), more preferably 0.2 to 4.5% (w/w), more preferably 0.3 to 4.0% (w/w), more preferably 0.4 to 3.5% (w/w), more preferably 0.5 to 3.0% (w/w), more preferably 0.6 to 2.5% (w/w), more preferably 0.7 to 2.0% (w/w), more preferably 0.8 to 1.5% (w/w), such as 1.0% (w/w).
- An amount of 0.05 to 1.0% (w/w) is particularly preferred.
- the amount of glucose present in the composition is at least 0.3 (w/w), at least 0.4 (w/w), at least 0.5 (w/w), at least 0.6 (w/w), at least 0.7 (w/w), at least 0.8 (w/w), at least 0.9 (w/w), at least 1.0 (w/w), at least 2.0 (w/w), or at least 3.0 (w/w).
- the urea is present in the composition in an amount of 0.05 to 5.0% (w/w), more preferably 0.1 to 5.0% (w/w), more preferably 0.2 to 4.5% (w/w), more preferably 0.3 to 4.0% (w/w), more preferably 0.4 to 3.5% (w/w), more preferably 0.5 to 3.0% (w/w), more preferably 0.6 to 2.5% (w/w), more preferably 0.7 to 2.0% (w/w), more preferably 0.8 to 1.5% (w/w), such as 1.0% (w/w).
- the amount of urea present in the composition is at least 0.3 (w/w), at least 0.4 (w/w), at least 0.5 (w/w), at least 0.6 (w/w), at least 0.7 (w/w), at least 0.8 (w/w), at least 0.9 (w/w), at least 1.0 (w/w), at least 2.0 (w/w), or at least 3.0 (w/w).
- This composition may optionally include caprylic/capric triglycerides as a lipid source.
- the caprylic/capric triglycerides are preferably present in an amount of 0.1 to 6.0% (w/w), more preferably 0.2 to 6.0% (w/w), more preferably 0.3 to 5.5% (w/w), more preferably 0.4 to 5.0% (w/w), more preferably 0.5 to 4.5% (w/w), more preferably 0.6 to 4.0% (w/w), more preferably 0.7 to 3.5% (w/w), more preferably 0.8 to 3.0% (w/w), more preferably 0.9 to 2.5% (w/w), more preferably 1.0 to 3.0% (w/w), more preferably 1.5 to 2.5% (w/w), such as 2.0% (w/w).
- the amount of caprylic/capric triglycerides present in the composition is at least 0.3 (w/w), at least 0.4 (w/w), at least 0.5 (w/w), at least 0.6 (w/w), at least 0.7 (w/w), at least 0.8 (w/w), at least 0.9 (w/w), at least 1.0 (w/w), at least 2.0 (w/w), at least 3.0 (w/w), at least 4.0 (w/w), or at least 5.0 (w/w).
- Another preferred skin care composition of the invention comprises the following:
- caprylic/capric triglycerides as a lipid source.
- the glucose is preferably present in the composition in an amount as outlined above.
- the arginine is preferably present in the composition in an amount of 0.05 to 5.0% (w/w), more preferably 0.1 to 5.0% (w/w), more preferably 0.2 to 4.5% (w/w), more preferably 0.3 to 4.0% (w/w), more preferably 0.4 to 3.5% (w/w), more preferably 0.5 to 3.0% (w/w), more preferably 0.6 to 2.5% (w/w), more preferably 0.8 to 2.0% (w/w), more preferably 0.9 to 1.5% (w/w), such as 1.0% (w/w).
- the amount of arginine present in the composition is at least 0.3 (w/w), at least 0.4 (w/w), at least 0.5 (w/w), at least 0.6 (w/w), at least 0.7 (w/w), at least 0.8 (w/w), at least 0.9 (w/w), at least 1.0 (w/w), at least 2.0 (w/w), or at least 3.0 (w/w).
- This composition may optionally include caprylic/capric triglycerides as a lipid source. If present, the caprylic/capric triglycerides are preferably used in the amounts outlines above.
- Another preferred skin care composition of the invention comprises the following:
- caprylic/capric triglycerides as a lipid source.
- the glucose is preferably present in the composition in an amount as outlined above.
- the glycine is preferably present in the composition in an amount of 0.05 to 5.0% (w/w), more preferably 0.1 to 5.0% (w/w), more preferably 0.2 to 4.5% (w/w), more preferably 0.3 to 4.0% (w/w), more preferably 0.4 to 3.5% (w/w), more preferably 0.5 to 3.0% (w/w), more preferably 0.6 to 2.5% (w/w), more preferably 0.8 to 2.0% (w/w), more preferably 0.9 to 1.5% (w/w), such as 1.0% (w/w).
- the amount of glycine present in the composition is at least 0.3 (w/w), at least 0.4 (w/w), at least 0.5 (w/w), at least 0.6 (w/w), at least 0.7 (w/w), at least 0.8 (w/w), at least 0.9 (w/w), at least 1.0 (w/w), at least 2.0 (w/w), or at least 3.0 (w/w).
- This composition may optionally include caprylic/capric triglycerides as a lipid source. If present, the caprylic/capric triglycerides are preferably used in the amounts outlines above.
- Another preferred skin care composition of the invention comprises the following:
- caprylic/capric triglycerides as a lipid source.
- the glucose is preferably present in the composition in an amount as outlined above.
- the alanine is preferably present in the composition in an amount of 0.05 to 5.0% (w/w), more preferably 0.1 to 5.0% (w/w), more preferably 0.2 to 4.5% (w/w), more preferably 0.3 to 4.0% (w/w), more preferably 0.4 to 3.5% (w/w), more preferably 0.5 to 3.0% (w/w), more preferably 0.6 to 2.5% (w/w), more preferably 0.8 to 2.0% (w/w), more preferably 0.9 to 1.5% (w/w), such as 1.0% (w/w).
- the amount of alanine present in the composition is at least 0.3 (w/w), at least 0.4 (w/w), at least 0.5 (w/w), at least 0.6 (w/w), at least 0.7 (w/w), at least 0.8 (w/w), at least 0.9 (w/w), at least 1.0 (w/w), at least 2.0 (w/w), or at least 3.0 (w/w).
- This composition may optionally include caprylic/capric triglycerides as a lipid source. If present, the caprylic/capric triglycerides are preferably used in the amounts outlines above.
- Another preferred skin care composition of the invention comprises the following:
- caprylic/capric triglycerides as a lipid source.
- the fructose is present in the composition in an amount of 0.05 to 5.0% (w/w), more preferably 0.1 to 5.0% (w/w), more preferably 0.2 to 4.5% (w/w), more preferably 0.3 to 4.0% (w/w), more preferably 0.4 to 3.5% (w/w), more preferably 0.5 to 3.0% (w/w), more preferably 0.6 to 2.5% (w/w), more preferably 0.7 to 2.0% (w/w), more preferably 0.8 to 1.5% (w/w), such as 1.0% (w/w).
- An amount of 0.05 to 1.0% (w/w) is particularly preferred.
- the amount of fructose present in the composition is at least 0.3 (w/w), at least 0.4 (w/w), at least 0.5 (w/w), at least 0.6 (w/w), at least 0.7 (w/w), at least 0.8 (w/w), at least 0.9 (w/w), at least 1.0 (w/w), at least 2.0 (w/w), or at least 3.0 (w/w).
- the urea is present in the composition in an amount of 0.05 to 5.0% (w/w), more preferably 0.1 to 5.0% (w/w), more preferably 0.2 to 4.5% (w/w), more preferably 0.3 to 4.0% (w/w), more preferably 0.4 to 3.5% (w/w), more preferably 0.5 to 3.0% (w/w), more preferably 0.6 to 2.5% (w/w), more preferably 0.7 to 2.0% (w/w), more preferably 0.8 to 1.5% (w/w), such as 1.0% (w/w).
- the amount of urea present in the composition is at least 0.3 (w/w), at least 0.4 (w/w), at least 0.5 (w/w), at least 0.6 (w/w), at least 0.7 (w/w), at least 0.8 (w/w), at least 0.9 (w/w), at least 1.0 (w/w), at least 2.0 (w/w), or at least 3.0 (w/w).
- This composition may optionally include caprylic/capric triglycerides as a lipid source.
- the caprylic/capric triglycerides are preferably present in an amount of 0.1 to 6.0% (w/w), more preferably 0.2 to 6.0% (w/w), more preferably 0.3 to 5.5% (w/w), more preferably 0.4 to 5.0% (w/w), more preferably 0.5 to 4.5% (w/w), more preferably 0.6 to 4.0% (w/w), more preferably 0.7 to 3.5% (w/w), more preferably 0.8 to 3.0% (w/w), more preferably 0.9 to 2.5% (w/w), more preferably 1.0 to 3.0% (w/w), more preferably 1.5 to 2.5% (w/w), such as 2.0% (w/w).
- the amount of caprylic/capric triglycerides present in the composition is at least 0.3 (w/w), at least 0.4 (w/w), at least 0.5 (w/w), at least 0.6 (w/w), at least 0.7 (w/w), at least 0.8 (w/w), at least 0.9 (w/w), at least 1.0 (w/w), at least 2.0 (w/w), at least 3.0 (w/w), at least 4.0 (w/w), or at least 5.0 (w/w).
- Another preferred skin care composition of the invention comprises the following:
- caprylic/capric triglycerides as a lipid source.
- the fructose is preferably present in the composition in an amount as outlined above.
- the arginine is preferably present in the composition in an amount of 0.05 to 5.0% (w/w), more preferably 0.1 to 5.0% (w/w), more preferably 0.2 to 4.5% (w/w), more preferably 0.3 to 4.0% (w/w), more preferably 0.4 to 3.5% (w/w), more preferably 0.5 to 3.0% (w/w), more preferably 0.6 to 2.5% (w/w), more preferably 0.8 to 2.0% (w/w), more preferably 0.9 to 1.5% (w/w), such as 1.0% (w/w).
- the amount of arginine present in the composition is at least 0.3 (w/w), at least 0.4 (w/w), at least 0.5 (w/w), at least 0.6 (w/w), at least 0.7 (w/w), at least 0.8 (w/w), at least 0.9 (w/w), at least 1.0 (w/w), at least 2.0 (w/w), or at least 3.0 (w/w).
- This composition may optionally include caprylic/capric triglycerides as a lipid source. If present, the caprylic/capric triglycerides are preferably used in the amounts outlines above.
- Another preferred skin care composition of the invention comprises the following:
- caprylic/capric triglycerides as a lipid source.
- the fructose is preferably present in the composition in an amount as outlined above.
- the glycine is preferably present in the composition in an amount of 0.05 to 5.0% (w/w), more preferably 0.1 to 5.0% (w/w), more preferably 0.2 to 4.5% (w/w), more preferably 0.3 to 4.0% (w/w), more preferably 0.4 to 3.5% (w/w), more preferably 0.5 to 3.0% (w/w), more preferably 0.6 to 2.5% (w/w), more preferably 0.8 to 2.0% (w/w), more preferably 0.9 to 1.5% (w/w), such as 1.0% (w/w).
- the amount of glycine present in the composition is at least 0.3 (w/w), at least 0.4 (w/w), at least 0.5 (w/w), at least 0.6 (w/w), at least 0.7 (w/w), at least 0.8 (w/w), at least 0.9 (w/w), at least 1.0 (w/w), at least 2.0 (w/w), or at least 3.0 (w/w).
- This composition may optionally include caprylic/capric triglycerides as a lipid source. If present, the caprylic/capric triglycerides are preferably used in the amounts outlines above.
- Another preferred skin care composition of the invention comprises the following:
- caprylic/capric triglycerides as a lipid source.
- the fructose is preferably present in the composition in an amount as outlined above.
- the alanine is preferably present in the composition in an amount of 0.05 to 5.0% (w/w), more preferably 0.1 to 5.0% (w/w), more preferably 0.2 to 4.5% (w/w), more preferably 0.3 to 4.0% (w/w), more preferably 0.4 to 3.5% (w/w), more preferably 0.5 to 3.0% (w/w), more preferably 0.6 to 2.5% (w/w), more preferably 0.8 to 2.0% (w/w), more preferably 0.9 to 1.5% (w/w), such as 1.0% (w/w).
- the amount of alanine present in the composition is at least 0.3 (w/w), at least 0.4 (w/w), at least 0.5 (w/w), at least 0.6 (w/w), at least 0.7 (w/w), at least 0.8 (w/w), at least 0.9 (w/w), at least 1.0 (w/w), at least 2.0 (w/w), or at least 3.0 (w/w).
- This composition may optionally include caprylic/capric triglycerides as a lipid source. If present, the caprylic/capric triglycerides are preferably used in the amounts outlines above.
- Another preferred skin care composition of the invention comprises the following:
- caprylic/capric triglycerides as a lipid source.
- the maltose is present in the composition in an amount of 0.05 to 5.0% (w/w), more preferably 0.1 to 5.0% (w/w), more preferably 0.2 to 4.5% (w/w), more preferably 0.3 to 4.0% (w/w), more preferably 0.4 to 3.5% (w/w), more preferably 0.5 to 3.0% (w/w), more preferably 0.6 to 2.5% (w/w), more preferably 0.7 to 2.0% (w/w), more preferably 0.8 to 1.5% (w/w), such as 1.0% (w/w).
- An amount of 0.05 to 1.0% (w/w) is particularly preferred.
- the amount of maltose present in the composition is at least 0.3 (w/w), at least 0.4 (w/w), at least 0.5 (w/w), at least 0.6 (w/w), at least 0.7 (w/w), at least 0.8 (w/w), at least 0.9 (w/w), at least 1.0 (w/w), at least 2.0 (w/w), or at least 3.0 (w/w).
- the urea is present in the composition in an amount of 0.05 to 5.0% (w/w), more preferably 0.1 to 5.0% (w/w), more preferably 0.2 to 4.5% (w/w), more preferably 0.3 to 4.0% (w/w), more preferably 0.4 to 3.5% (w/w), more preferably 0.5 to 3.0% (w/w), more preferably 0.6 to 2.5% (w/w), more preferably 0.7 to 2.0% (w/w), more preferably 0.8 to 1.5% (w/w), such as 1.0% (w/w).
- the amount of urea present in the composition is at least 0.3 (w/w), at least 0.4 (w/w), at least 0.5 (w/w), at least 0.6 (w/w), at least 0.7 (w/w), at least 0.8 (w/w), at least 0.9 (w/w), at least 1.0 (w/w), at least 2.0 (w/w), or at least 3.0 (w/w).
- This composition may optionally include caprylic/capric triglycerides as a lipid source.
- the caprylic/capric triglycerides are preferably present in an amount of 0.1 to 6.0% (w/w), more preferably 0.2 to 6.0% (w/w), more preferably 0.3 to 5.5% (w/w), more preferably 0.4 to 5.0% (w/w), more preferably 0.5 to 4.5% (w/w), more preferably 0.6 to 4.0% (w/w), more preferably 0.7 to 3.5% (w/w), more preferably 0.8 to 3.0% (w/w), more preferably 0.9 to 2.5% (w/w), more preferably 1.0 to 3.0% (w/w), more preferably 1.5 to 2.5% (w/w), such as 2.0% (w/w).
- the amount of caprylic/capric triglycerides present in the composition is at least 0.3 (w/w), at least 0.4 (w/w), at least 0.5 (w/w), at least 0.6 (w/w), at least 0.7 (w/w), at least 0.8 (w/w), at least 0.9 (w/w), at least 1.0 (w/w), at least 2.0 (w/w), at least 3.0 (w/w), at least 4.0 (w/w), or at least 5.0 (w/w).
- Another preferred skin care composition of the invention comprises the following:
- caprylic/capric triglycerides as a lipid source.
- the maltose is preferably present in the composition in an amount as outlined above.
- the arginine is preferably present in the composition in an amount of 0.05 to 5.0% (w/w), more preferably 0.1 to 5.0% (w/w), more preferably 0.2 to 4.5% (w/w), more preferably 0.3 to 4.0% (w/w), more preferably 0.4 to 3.5% (w/w), more preferably 0.5 to 3.0% (w/w), more preferably 0.6 to 2.5% (w/w), more preferably 0.8 to 2.0% (w/w), more preferably 0.9 to 1.5% (w/w), such as 1.0% (w/w).
- the amount of arginine present in the composition is at least 0.3 (w/w), at least 0.4 (w/w), at least 0.5 (w/w), at least 0.6 (w/w), at least 0.7 (w/w), at least 0.8 (w/w), at least 0.9 (w/w), at least 1.0 (w/w), at least 2.0 (w/w), or at least 3.0 (w/w).
- This composition may optionally include caprylic/capric triglycerides as a lipid source. If present, the caprylic/capric triglycerides are preferably used in the amounts outlines above.
- Another preferred skin care composition of the invention comprises the following:
- caprylic/capric triglycerides as a lipid source.
- the maltose is preferably present in the composition in an amount as outlined above.
- the glycine is preferably present in the composition in an amount of 0.05 to 5.0% (w/w), more preferably 0.1 to 5.0% (w/w), more preferably 0.2 to 4.5% (w/w), more preferably 0.3 to 4.0% (w/w), more preferably 0.4 to 3.5% (w/w), more preferably 0.5 to 3.0% (w/w), more preferably 0.6 to 2.5% (w/w), more preferably 0.8 to 2.0% (w/w), more preferably 0.9 to 1.5% (w/w), such as 1.0% (w/w).
- the amount of glycine present in the composition is at least 0.3 (w/w), at least 0.4 (w/w), at least 0.5 (w/w), at least 0.6 (w/w), at least 0.7 (w/w), at least 0.8 (w/w), at least 0.9 (w/w), at least 1.0 (w/w), at least 2.0 (w/w), or at least 3.0 (w/w).
- This composition may optionally include caprylic/capric triglycerides as a lipid source. If present, the caprylic/capric triglycerides are preferably used in the amounts outlines above.
- Another preferred skin care composition of the invention comprises the following:
- caprylic/capric triglycerides as a lipid source.
- the maltose is preferably present in the composition in an amount as outlined above.
- the alanine is preferably present in the composition in an amount of 0.05 to 5.0% (w/w), more preferably 0.1 to 5.0% (w/w), more preferably 0.2 to 4.5% (w/w), more preferably 0.3 to 4.0% (w/w), more preferably 0.4 to 3.5% (w/w), more preferably 0.5 to 3.0% (w/w), more preferably 0.6 to 2.5% (w/w), more preferably 0.8 to 2.0% (w/w), more preferably 0.9 to 1.5% (w/w), such as 1.0% (w/w).
- the amount of alanine present in the composition is at least 0.3 (w/w), at least 0.4 (w/w), at least 0.5 (w/w), at least 0.6 (w/w), at least 0.7 (w/w), at least 0.8 (w/w), at least 0.9 (w/w), at least 1.0 (w/w), at least 2.0 (w/w), or at least 3.0 (w/w).
- This composition may optionally include caprylic/capric triglycerides as a lipid source. If present, the caprylic/capric triglycerides are preferably used in the amounts outlines above.
- Another preferred skin care composition of the invention comprises the following:
- caprylic/capric triglycerides as a lipid source.
- the saccharose is present in the composition in an amount of 0.05 to 5.0% (w/w), more preferably 0.1 to 5.0% (w/w), more preferably 0.2 to 4.5% (w/w), more preferably 0.3 to 4.0% (w/w), more preferably 0.4 to 3.5% (w/w), more preferably 0.5 to 3.0% (w/w), more preferably 0.6 to 2.5% (w/w), more preferably 0.7 to 2.0% (w/w), more preferably 0.8 to 1.5% (w/w), such as 1.0% (w/w).
- An amount of 0.05 to 1.0% (w/w) is particularly preferred.
- the amount of saccharose present in the composition is at least 0.3 (w/w), at least 0.4 (w/w), at least 0.5 (w/w), at least 0.6 (w/w), at least 0.7 (w/w), at least 0.8 (w/w), at least 0.9 (w/w), at least 1.0 (w/w), at least 2.0 (w/w), or at least 3.0 (w/w).
- the urea is present in the composition in an amount of 0.05 to 5.0% (w/w), more preferably 0.1 to 5.0% (w/w), more preferably 0.2 to 4.5% (w/w), more preferably 0.3 to 4.0% (w/w), more preferably 0.4 to 3.5% (w/w), more preferably 0.5 to 3.0% (w/w), more preferably 0.6 to 2.5% (w/w), more preferably 0.7 to 2.0% (w/w), more preferably 0.8 to 1.5% (w/w), such as 1.0% (w/w).
- the amount of urea present in the composition is at least 0.3 (w/w), at least 0.4 (w/w), at least 0.5 (w/w), at least 0.6 (w/w), at least 0.7 (w/w), at least 0.8 (w/w), at least 0.9 (w/w), at least 1.0 (w/w), at least 2.0 (w/w), or at least 3.0 (w/w).
- This composition may optionally include caprylic/capric triglycerides as a lipid source.
- the caprylic/capric triglycerides are preferably present in an amount of 0.1 to 6.0% (w/w), more preferably 0.2 to 6.0% (w/w), more preferably 0.3 to 5.5% (w/w), more preferably 0.4 to 5.0% (w/w), more preferably 0.5 to 4.5% (w/w), more preferably 0.6 to 4.0% (w/w), more preferably 0.7 to 3.5% (w/w), more preferably 0.8 to 3.0% (w/w), more preferably 0.9 to 2.5% (w/w), more preferably 1.0 to 3.0% (w/w), more preferably 1.5 to 2.5% (w/w), such as 2.0% (w/w).
- the amount of caprylic/capric triglycerides present in the composition is at least 0.3 (w/w), at least 0.4 (w/w), at least 0.5 (w/w), at least 0.6 (w/w), at least 0.7 (w/w), at least 0.8 (w/w), at least 0.9 (w/w), at least 1.0 (w/w), at least 2.0 (w/w), at least 3.0 (w/w), at least 4.0 (w/w), or at least 5.0 (w/w).
- Another preferred skin care composition of the invention comprises the following:
- caprylic/capric triglycerides as a lipid source.
- the saccharose is preferably present in the composition in an amount as outlined above.
- the arginine is preferably present in the composition in an amount of 0.05 to 5.0% (w/w), more preferably 0.1 to 5.0% (w/w), more preferably 0.2 to 4.5% (w/w), more preferably 0.3 to 4.0% (w/w), more preferably 0.4 to 3.5% (w/w), more preferably 0.5 to 3.0% (w/w), more preferably 0.6 to 2.5% (w/w), more preferably 0.8 to 2.0% (w/w), more preferably 0.9 to 1.5% (w/w), such as 1.0% (w/w).
- the amount of arginine present in the composition is at least 0.3 (w/w), at least 0.4 (w/w), at least 0.5 (w/w), at least 0.6 (w/w), at least 0.7 (w/w), at least 0.8 (w/w), at least 0.9 (w/w), at least 1.0 (w/w), at least 2.0 (w/w), or at least 3.0 (w/w).
- This composition may optionally include caprylic/capric triglycerides as a lipid source. If present, the caprylic/capric triglycerides are preferably used in the amounts outlines above.
- Another preferred skin care composition of the invention comprises the following:
- caprylic/capric triglycerides as a lipid source.
- the saccharose is preferably present in the composition in an amount as outlined above.
- the glycine is preferably present in the composition in an amount of 0.05 to 5.0% (w/w), more preferably 0.1 to 5.0% (w/w), more preferably 0.2 to 4.5% (w/w), more preferably 0.3 to 4.0% (w/w), more preferably 0.4 to 3.5% (w/w), more preferably 0.5 to 3.0% (w/w), more preferably 0.6 to 2.5% (w/w), more preferably 0.8 to 2.0% (w/w), more preferably 0.9 to 1.5% (w/w), such as 1.0% (w/w).
- the amount of glycine present in the composition is at least 0.3 (w/w), at least 0.4 (w/w), at least 0.5 (w/w), at least 0.6 (w/w), at least 0.7 (w/w), at least 0.8 (w/w), at least 0.9 (w/w), at least 1.0 (w/w), at least 2.0 (w/w), or at least 3.0 (w/w).
- This composition may optionally include caprylic/capric triglycerides as a lipid source. If present, the caprylic/capric triglycerides are preferably used in the amounts outlines above.
- Another preferred skin care composition of the invention comprises the following:
- caprylic/capric triglycerides as a lipid source.
- the saccharose is preferably present in the composition in an amount as outlined above.
- the alanine is preferably present in the composition in an amount of 0.05 to 5.0% (w/w), more preferably 0.1 to 5.0% (w/w), more preferably 0.2 to 4.5% (w/w), more preferably 0.3 to 4.0% (w/w), more preferably 0.4 to 3.5% (w/w), more preferably 0.5 to 3.0% (w/w), more preferably 0.6 to 2.5% (w/w), more preferably 0.8 to 2.0% (w/w), more preferably 0.9 to 1.5% (w/w), such as 1.0% (w/w).
- the amount of alanine present in the composition is at least 0.3 (w/w), at least 0.4 (w/w), at least 0.5 (w/w), at least 0.6 (w/w), at least 0.7 (w/w), at least 0.8 (w/w), at least 0.9 (w/w), at least 1.0 (w/w), at least 2.0 (w/w), or at least 3.0 (w/w).
- This composition may optionally include caprylic/capric triglycerides as a lipid source. If present, the caprylic/capric triglycerides are preferably used in the amounts outlines above.
- Another preferred skin care composition of the invention comprises the following:
- caprylic/capric triglycerides as a lipid source.
- the maltodextrin is present in the composition in an amount of 0.05 to 5.0% (w/w), more preferably 0.1 to 5.0% (w/w), more preferably 0.2 to 4.5% (w/w), more preferably 0.3 to 4.0% (w/w), more preferably 0.4 to 3.5% (w/w), more preferably 0.5 to 3.0% (w/w), more preferably 0.6 to 2.5% (w/w), more preferably 0.7 to 2.0% (w/w), more preferably 0.8 to 1.5% (w/w), such as 1.0% (w/w).
- An amount of 0.05 to 1.0% (w/w) is particularly preferred.
- the amount of maltodextrin present in the composition is at least 0.3 (w/w), at least 0.4 (w/w), at least 0.5 (w/w), at least 0.6 (w/w), at least 0.7 (w/w), at least 0.8 (w/w), at least 0.9 (w/w), at least 1.0 (w/w), at least 2.0 (w/w), or at least 3.0 (w/w).
- the urea is present in the composition in an amount of 0.05 to 5.0% (w/w), more preferably 0.1 to 5.0% (w/w), more preferably 0.2 to 4.5% (w/w), more preferably 0.3 to 4.0% (w/w), more preferably 0.4 to 3.5% (w/w), more preferably 0.5 to 3.0% (w/w), more preferably 0.6 to 2.5% (w/w), more preferably 0.7 to 2.0% (w/w), more preferably 0.8 to 1.5% (w/w), such as 1.0% (w/w).
- the amount of urea present in the composition is at least 0.3 (w/w), at least 0.4 (w/w), at least 0.5 (w/w), at least 0.6 (w/w), at least 0.7 (w/w), at least 0.8 (w/w), at least 0.9 (w/w), at least 1.0 (w/w), at least 2.0 (w/w), or at least 3.0 (w/w).
- This composition may optionally include caprylic/capric triglycerides as a lipid source.
- the caprylic/capric triglycerides are preferably present in an amount of 0.1 to 6.0% (w/w), more preferably 0.2 to 6.0% (w/w), more preferably 0.3 to 5.5% (w/w), more preferably 0.4 to 5.0% (w/w), more preferably 0.5 to 4.5% (w/w), more preferably 0.6 to 4.0% (w/w), more preferably 0.7 to 3.5% (w/w), more preferably 0.8 to 3.0% (w/w), more preferably 0.9 to 2.5% (w/w), more preferably 1.0 to 3.0% (w/w), more preferably 1.5 to 2.5% (w/w), such as 2.0% (w/w).
- the amount of caprylic/capric triglycerides present in the composition is at least 0.3 (w/w), at least 0.4 (w/w), at least 0.5 (w/w), at least 0.6 (w/w), at least 0.7 (w/w), at least 0.8 (w/w), at least 0.9 (w/w), at least 1.0 (w/w), at least 2.0 (w/w), at least 3.0 (w/w), at least 4.0 (w/w), or at least 5.0 (w/w).
- Another preferred skin care composition of the invention comprises the following:
- caprylic/capric triglycerides as a lipid source.
- the maltodextrin is preferably present in the composition in an amount as outlined above.
- the arginine is preferably present in the composition in an amount of 0.05 to 5.0% (w/w), more preferably 0.1 to 5.0% (w/w), more preferably 0.2 to 4.5% (w/w), more preferably 0.3 to 4.0% (w/w), more preferably 0.4 to 3.5% (w/w), more preferably 0.5 to 3.0% (w/w), more preferably 0.6 to 2.5% (w/w), more preferably 0.8 to 2.0% (w/w), more preferably 0.9 to 1.5% (w/w), such as 1.0% (w/w).
- the amount of arginine present in the composition is at least 0.3 (w/w), at least 0.4 (w/w), at least 0.5 (w/w), at least 0.6 (w/w), at least 0.7 (w/w), at least 0.8 (w/w), at least 0.9 (w/w), at least 1.0 (w/w), at least 2.0 (w/w), or at least 3.0 (w/w).
- This composition may optionally include caprylic/capric triglycerides as a lipid source. If present, the caprylic/capric triglycerides are preferably used in the amounts outlines above.
- Another preferred skin care composition of the invention comprises the following:
- caprylic/capric triglycerides as a lipid source.
- the maltodextrin is preferably present in the composition in an amount as outlined above.
- the glycine is preferably present in the composition in an amount of 0.05 to 5.0% (w/w), more preferably 0.1 to 5.0% (w/w), more preferably 0.2 to 4.5% (w/w), more preferably 0.3 to 4.0% (w/w), more preferably 0.4 to 3.5% (w/w), more preferably 0.5 to 3.0% (w/w), more preferably 0.6 to 2.5% (w/w), more preferably 0.8 to 2.0% (w/w), more preferably 0.9 to 1.5% (w/w), such as 1.0% (w/w).
- the amount of glycine present in the composition is at least 0.3 (w/w), at least 0.4 (w/w), at least 0.5 (w/w), at least 0.6 (w/w), at least 0.7 (w/w), at least 0.8 (w/w), at least 0.9 (w/w), at least 1.0 (w/w), at least 2.0 (w/w), or at least 3.0 (w/w).
- This composition may optionally include caprylic/capric triglycerides as a lipid source. If present, the caprylic/capric triglycerides are preferably used in the amounts outlines above.
- Another preferred skin care composition of the invention comprises the following:
- caprylic/capric triglycerides as a lipid source.
- the maltodextrin is preferably present in the composition in an amount as outlined above.
- the alanine is preferably present in the composition in an amount of 0.05 to 5.0% (w/w), more preferably 0.1 to 5.0% (w/w), more preferably 0.2 to 4.5% (w/w), more preferably 0.3 to 4.0% (w/w), more preferably 0.4 to 3.5% (w/w), more preferably 0.5 to 3.0% (w/w), more preferably 0.6 to 2.5% (w/w), more preferably 0.8 to 2.0% (w/w), more preferably 0.9 to 1.5% (w/w), such as 1.0% (w/w).
- the amount of alanine present in the composition is at least 0.3 (w/w), at least 0.4 (w/w), at least 0.5 (w/w), at least 0.6 (w/w), at least 0.7 (w/w), at least 0.8 (w/w), at least 0.9 (w/w), at least 1.0 (w/w), at least 2.0 (w/w), or at least 3.0 (w/w).
- This composition may optionally include caprylic/capric triglycerides as a lipid source. If present, the caprylic/capric triglycerides are preferably used in the amounts outlines above.
- compositions of the invention include, but are not limited to:
- a skin care composition comprising:
- a skin care composition comprising:
- a skin care composition comprising:
- a skin care composition comprising:
- a skin care composition comprising:
- a skin care composition comprising:
- a skin care composition comprising:
- a skin care composition comprising:
- a skin care composition comprising:
- a skin care composition comprising:
- a skin care composition comprising:
- a skin care composition comprising:
- a skin care composition comprising:
- a skin care composition comprising:
- a skin care composition comprising:
- a skin care composition comprising:
- a skin care composition comprising:
- a skin care composition comprising:
- a skin care composition comprising:
- a skin care composition comprising:
- a skin care composition comprising:
- a skin care composition comprising:
- a skin care composition comprising:
- a skin care composition comprising:
- a skin care composition comprising:
- a skin care composition comprising:
- a skin care composition comprising: (a) 0.5 to 3.0% (w/w) maltose as a carbon source,
- a skin care composition comprising:
- a skin care composition comprising:
- a skin care composition comprising:
- a skin care composition comprising:
- a skin care composition comprising:
- a skin care composition comprising:
- a skin care composition comprising:
- a skin care composition comprising:
- a skin care composition comprising:
- a skin care composition comprising:
- a skin care composition comprising:
- a skin care composition comprising:
- a skin care composition comprising:
- a skin care composition comprising:
- a skin care composition comprising:
- a skin care composition comprising:
- a skin care composition comprising:
- a skin care composition comprising:
- a skin care composition comprising: (a) 0.5 to 3.0% (w/w) pyruvic acid, pyruvate or a mixture thereof as a carbon source,
- a skin care composition comprising:
- a skin care composition comprising:
- a skin care composition comprising:
- a skin care composition comprising:
- a skin care composition comprising:
- a skin care composition comprising:
- a skin care composition comprising:
- a skin care composition comprising:
- mixtures of amino acids can be used according to the present invention, for example, mixtures comprising one or more of alanine, arginine, serine, threonine, histidine, glutamic acid and/or lysine can be used. Mixtures of alanine and arginine are particularly preferred.
- the betaine is preferably present in the composition in an amount of 0.05 to 5.0% (w/w), more preferably 0.1 to 5.0% (w/w), more preferably 0.2 to 4.5% (w/w), more preferably 0.3 to 4.0% (w/w), more preferably 0.4 to 3.5% (w/w), more preferably 0.5 to 3.0% (w/w), more preferably 0.6 to 2.5% (w/w), more preferably 0.8 to 2.0% (w/w), more preferably 0.9 to 1.5% (w/w), such as 1.0% (w/w).
- the amount of betaine present in the composition is at least 0.3 (w/w), at least 0.4 (w/w), at least 0.5 (w/w), at least 0.6 (w/w), at least 0.7 (w/w), at least 0.8 (w/w), at least 0.9 (w/w), at least 1.0 (w/w), at least 2.0 (w/w), or at least 3.0 (w/w).
- the skin care composition of the invention is formulated as a water-containing composition for topical application to the skin that has a particularly low osmolality. It has been found that it is possible to further support a healthy and stable microbiome by reducing osmolality.
- a high number of osmotically active solutes in the compositions leads to a high level of osmotic stress after application of the composition to the skin.
- the water contained in the composition evaporates to a significant extent so that the remaining water on the skin surface comprises salts and other osmotically active components in highly concentrated form.
- These concentrated compounds are able to bind free water in the environment which is crucial for the bacterial metabolism and hence for viability of the bacteria.
- water from inside of the bacterial cells diffuses along the osmotic gradient to the outside. This severely impacts viability of the bacterial cells.
- the osmolality of a solution quantifies the osmotically active particles or ions contained in a solution.
- osmolality refers to the mass weight. It is normally expressed as mOsm/kg water or mmol/kg water.
- the actual osmolality of a composition can be determined in accordance with methods well-known in the art. For example, osmolality can be measured by using a freezing point depression osmometer or a vapour pressure depression osmometer. Since the freezing point of a water-based composition is depressed dependent on the number of osmotically active particles or ions contained, it is possible to measure osmolality by determining the freezing point of the composition.
- the osmolality of a composition is often determined in practice by calculation the "theoretical osmolality" based on the molar masses of the compounds contained in said composition and the amounts of the compounds in the composition.
- the theoretical osmolality b osm indicates the molality of the osmotically active particles in a solution. It is calculated according to the formula: Solvent wherein n osm indicates the amount of osmotically active particles in moles and m So ivent indicates the mass of the solvent in kg.
- the skin care composition has a theoretical osmolality of 4000 mOsm/kg water or less.
- the composition has a theoretical osmolality of 3900 mOsm/kg water or less, 3800 mOsm/kg water or less, 3700 mOsm/kg water or less, 3600 mOsm/kg water or less, 3500 mOsm/kg water or less, 3400 mOsm/kg water or less, 3300 mOsm/kg water or less, 3200 mOsm/kg water or less, 3100 mOsm/kg water or less, or 3000 mOsm/kg water or less.
- skin care composition has a theoretical osmolality in the range between 3000-4000 mOsm/kg water, more preferably between 3100-3900 mOsm/kg water, between 3200-3800 mOsm/kg water, between 3300-3700 mOsm/kg water, or between 3400-3600 mOsm/kg water.
- the composition of the invention preferably is a water-containing composition.
- the water content of the composition preferably is 30% (w/w) water or more.
- the com- position of the invention preferably comprises 30% (w/w) water or more, 35% (w/w) water or more, 40% (w/w) water or more, 45% (w/w) water or more, 50% (w/w) water or more, 55% (w/w) water or more, 60% (w/w) water or more, 65% (w/w) water or more, 70% (w/w) water or more, 75% (w/w) water or more, 80% (w/w) water or more, or 85% (w/w) water or more. It is particularly preferred that the composition of the invention comprises at least 70% (w/w) or at least 75% (w/w) water.
- the skin care composition of the present invention is preferably formulated as a ready-to-use composition which is suitable for direct topical administration to the skin.
- a composition may be provided in different forms, including, but not limited to, in the form of a gel, lotion, fluid, cream, ointment, solution, a water-based emulsion, or the like.
- the skin care composition of the present invention is formulated as a gel or lotion.
- the skin care compositions of the invention will use only reduced amounts of compounds which, upon their dissolution in water, are osmotically active.
- certain osmotically active compounds like NaCI, KCI, CaCI 2 or MgCI 2 are completely omitted.
- the amount of NaCI in the composition which is to be administered to the skin is less than 1% (w/w), less than 0.9% (w/w), less than 0.8% (w/w), less than 0.7% (w/w), less than 0.6% (w/w), less than 0.5% (w/w), less than 0.4% (w/w), less than 0.3% (w/w), less than 0.2% (w/w), or less than 0.1% (w/w).
- the composition does not comprise any NaCI.
- the amount of KCI in the composition which is to be administered to the skin is less than 1% (w/w), less than 0.9% (w/w), less than 0.8% (w/w), less than 0.7% (w/w), less than 0.6% (w/w), less than 0.5% (w/w), less than 0.4% (w/w), less than 0.3% (w/w), less than 0.2% (w/w), or less than 0.1% (w/w).
- the composition does not comprise any KCI.
- the amount of CaCI 2 in the composition which is to be administered to the skin is less than 1% (w/w), less than 0.9% (w/w), less than 0.8% (w/w), less than 0.7% (w/w), less than 0.6% (w/w), less than 0.5% (w/w), less than 0.4% (w/w), less than 0.3% (w/w), less than 0.2% (w/w), or less than 0.1% (w/w).
- the composition does not comprise any CaCI 2 .
- the amount of MgCI 2 in the composition which is to be administered to the skin is less than 1% (w/w), less than 0.9% (w/w), less than 0.8% (w/w), less than 0.7% (w/w), less than 0.6% (w/w), less than 0.5% (w/w), less than 0.4% (w/w), less than 0.3% (w/w), less than 0.2% (w/w), or less than 0.1% (w/w).
- the composition does not comprise any MgCI 2 .
- glycerol Another component that contributes to osmolality is glycerol. It is preferred according to the invention that the amount of glycerol in the composition which is to be administered to the skin is less than 10% (w/w), less than 9% (w/w), less than 8% (w/w), less than 7% (w/w), less than 6% (w/w), less than 5% (w/w), less than 4% (w/w), less than 3% (w/w), less than 2% (w/w), or less than 1% (w/w). In a particularly preferred embodiment, the composition does not comprise any glycerol.
- the skin care composition of the invention as defined elsewhere hereinabove comprises less than 0.5% (w/w) of NaCI and less than 5% (w/w) of glycerol. In one embodiment, the composition comprises less than 0.5% (w/w) of NaCI and no glycerol. In another embodiment, the composition comprises less than 5% (w/w) of glycerol and no NaCI.
- the skin care composition comprises less than 0.5% (w/w) of KCI and less than 5% (w/w) of glycerol. In one embodiment, the composition comprises less than 0.5% (w/w) of KCI and no glycerol. In another embodiment, the composition comprises less than 5% (w/w) of glycerol and no KCI.
- the skin care composition comprises less than 0.5% (w/w) of CaCI 2 and less than 5% (w/w) of glycerol. In one embodiment, the composition comprises less than 0.5% (w/w) of CaCI 2 and no glycerol. In another embodiment, the composition comprises less than 5% (w/w) of glycerol and no CaCI 2 .
- the skin care composition comprises less than 0.5% (w/w) of MgCI 2 and less than 5% (w/w) of glycerol. In one embodiment, the composition comprises less than 0.5% (w/w) of MgCI 2 and no glycerol. In another embodiment, the composition comprises less than 5% (w/w) of glycerol and no MgCI 2 .
- a particularly preferred skin care composition of the invention therefore has an osmolality of 4000 mOsm/kg water or less and comprises (a) glucose, fructose, saccharose, maltose, maltodextrin, pyruvic acid, pyruvate, lactic acid, and/or lactate as a carbon source, preferably in an amount of 0.05 to 5.0% (w/w),
- caprylic/capric triglycerides as a lipid source preferably in an amount of 0.05 to 6.0% (w/w).
- Another particularly preferred skin care composition of the invention therefore has an osmolality of 4000 mOsm/kg water or less and comprises
- caprylic/capric triglycerides as a lipid source preferably in an amount of 0.05 to 6.0% (w/w).
- Another particularly preferred skin care composition of the invention therefore has an osmolality of 4000 mOsm/kg water or less and comprises
- caprylic/capric triglycerides as a lipid source preferably in an amount of 0.05 to 6.0% (w/w).
- Another particularly preferred skin care composition of the invention therefore has an osmolality of 4000 mOsm/kg water or less and comprises
- glucose, fructose, saccharose, maltose, maltodextrin, pyruvic acid, pyruvate, lactic acid, and/or lactate as a carbon source, preferably in an amount of 0.05 to 5.0% (w/w),
- caprylic/capric triglycerides as a lipid source preferably in an amount of 0.05 to 6.0% (w/w).
- a particularly preferred skin care composition of the invention therefore has an osmolality of 4000 mOsm/kg water or less and comprises
- a particularly preferred skin care composition of the invention therefore has an osmolality of 4000 mOsm/kg water or less and comprises
- a particularly preferred skin care composition of the invention therefore has an osmolality of 4000 mOsm/kg water or less and comprises
- a particularly preferred skin care composition of the invention therefore has an osmolality of 4000 mOsm/kg water or less and comprises
- a particularly preferred skin care composition of the invention therefore has an osmolality of 4000 mOsm/kg water or less and comprises
- a particularly preferred skin care composition of the invention therefore has an osmolality of 4000 mOsm/kg water or less and comprises
- a particularly preferred skin care composition of the invention therefore has an osmolality of 4000 mOsm/kg water or less and comprises
- a particularly preferred skin care composition of the invention therefore has an osmolality of 4000 mOsm/kg water or less and comprises (a) 0.5 to 3.0% (w/w) glucose, fructose, saccharose, maltose, maltodextrin, pyruvic acid, pyruvate, lactic acid and/or lactate as a carbon source,
- a particularly preferred skin care composition of the invention therefore has an osmolality of 4000 mOsm/kg water or less and comprises
- caprylic/capric triglycerides as a lipid source preferably in an amount of 0.05 to 6.0% (w/w).
- Another particularly preferred skin care composition of the invention therefore has an osmolality of 4000 mOsm/kg water or less and comprises
- no glycerol and at least one of the following: (e) alanine, glycine, urea and/or arginine as a nitrogen source, preferably in an amount of 0.05 to 5.0% (w/w),
- caprylic/capric triglycerides as a lipid source preferably in an amount of 0.05 to 6.0% (w/w).
- Another particularly preferred skin care composition of the invention therefore has an osmolality of 4000 mOsm/kg water or less and comprises
- caprylic/capric triglycerides as a lipid source preferably in an amount of 0.05 to 6.0% (w/w).
- Another particularly preferred skin care composition of the invention therefore has an osmolality of 4000 mOsm/kg water or less and comprises
- alanine, glycine, urea and/or arginine as a nitrogen source, preferably in an amount of 0.05 to 5.0% (w/w)
- caprylic/capric triglycerides as a lipid source preferably in an amount of 0.05 to 6.0% (w/w).
- a particularly preferred skin care composition of the invention therefore has an osmolality of 4000 mOsm/kg water or less and comprises
- a particularly preferred skin care composition of the invention therefore has an osmolality of 4000 mOsm/kg water or less and comprises
- a particularly preferred skin care composition of the invention therefore has an osmolality of 4000 mOsm/kg water or less and comprises
- a particularly preferred skin care composition of the invention therefore has an osmolality of 4000 mOsm/kg water or less and comprises
- a particularly preferred skin care composition of the invention therefore has an osmolality of 4000 mOsm/kg water or less and comprises
- a particularly preferred skin care composition of the invention therefore has an osmolality of 4000 mOsm/kg water or less and comprises
- a particularly preferred skin care composition of the invention therefore has an osmolality of 4000 mOsm/kg water or less and comprises
- a particularly preferred skin care composition of the invention therefore has an osmolality of 4000 mOsm/kg water or less and comprises
- Another particularly preferred skin care composition of the invention therefore has an osmolality of 4000 mOsm/kg water or less and comprises
- urea and/or arginine as a nitrogen source, preferably in an amount of 0.05 to 5.0% (w/w)
- caprylic/capric triglycerides as a lipid source preferably in an amount of 0.05 to 6.0% (w/w).
- Another particularly preferred skin care composition of the invention therefore has an osmolality of 4000 mOsm/kg water or less and comprises
- caprylic/capric triglycerides as a lipid source preferably in an amount of 0.05 to 6.0% (w/w).
- Another particularly preferred skin care composition of the invention therefore has an osmolality of 4000 mOsm/kg water or less and comprises
- caprylic/capric triglycerides as a lipid source preferably in an amount of 0.05 to 6.0% (w/w).
- a particularly preferred skin care composition of the invention therefore has an osmolality of 4000 mOsm/kg water or less and comprises (a) 0.05 to 5.0% (w/w) pyruvic acid, pyruvate or a mixture thereof as a carbon source,
- a particularly preferred skin care composition of the invention therefore has an osmolality of 4000 mOsm/kg water or less and comprises
- a particularly preferred skin care composition of the invention therefore has an osmolality of 4000 mOsm/kg water or less and comprises
- a particularly preferred skin care composition of the invention therefore has an osmolality of 4000 mOsm/kg water or less and comprises
- Another particularly preferred skin care composition of the invention therefore has an osmolality of 4000 mOsm/kg water or less and comprises
- caprylic/capric triglycerides as a lipid source preferably in an amount of 0.05 to 6.0% (w/w).
- Another particularly preferred skin care composition of the invention therefore has an osmolality of 4000 mOsm/kg water or less and comprises
- caprylic/capric triglycerides as a lipid source preferably in an amount of 0.05 to 6.0% (w/w).
- Another particularly preferred skin care composition of the invention therefore has an osmolality of 4000 mOsm/kg water or less and comprises (a) lactic acid and/or lactate as a carbon source, preferably in an amount of 0.05 to 5.0% (w/w),
- caprylic/capric triglycerides as a lipid source preferably in an amount of 0.05 to 6.0% (w/w).
- a particularly preferred skin care composition of the invention therefore has an osmolality of 4000 mOsm/kg water or less and comprises
- a particularly preferred skin care composition of the invention therefore has an osmolality of 4000 mOsm/kg water or less and comprises
- a particularly preferred skin care composition of the invention therefore has an osmolality of 4000 mOsm/kg water or less and comprises (a) 0.5 to 3.0% (w/w) lactic acid or lactate or a mixture thereof as a carbon source,
- a particularly preferred skin care composition of the invention therefore has an osmolality of 4000 mOsm/kg water or less and comprises
- a particularly preferred skin care composition of the invention therefore has an osmolality of 4000 mOsm/kg water or less and comprises
- caprylic/capric triglycerides as a lipid source preferably in an amount of 0.05 to 6.0% (w/w).
- Another particularly preferred skin care composition of the invention therefore has an osmolality of 4000 mOsm/kg water or less and comprises (a) pyruvic acid, pyruvate, lactic acid, lactate or a mixture thereof as a carbon source, preferably in an amount of 0.05 to 5.0% (w/w),
- caprylic/capric triglycerides as a lipid source preferably in an amount of 0.05 to 6.0% (w/w).
- Another particularly preferred skin care composition of the invention therefore has an osmolality of 4000 mOsm/kg water or less and comprises
- caprylic/capric triglycerides as a lipid source preferably in an amount of 0.05 to 6.0% (w/w).
- the skin care composition of the present invention can further comprise additional compounds which are normally present in topical skin compositions.
- the skin care composition of the present invention can further comprise at least one compound selected from the group consisting of perfumes, emollients, pigments, thickener, fillers, colorants, antioxidants, surfactants, lubricants, stabilizers, preservatives, solubilizers, emulsifiers and combinations of any of these.
- the compositions of the invention comprise hydrolyzed milk protein and/or a ginger compound, such as Zingiber officinale root juice, as additional components.
- the skin care compositions described herein are particularly useful for promoting and maintaining a healthy skin microbiome.
- the compositions preferably increase the overall number of microorganisms, more preferably the overall number of bacteria, in a skin areal to which the skin care compositions are applied. It is particularly preferred that the overall number of microorganisms, more preferably the overall number of bacteria, is increased after daily topical application of the composition over a period of 2-4 weeks by at least 2.5%, by at least 5%, by at least 7.5%, by at least 10%, by at least 12.5%, or by at least 15% relative to an untreated areal of the part of the body. It is particularly preferred that the number of bacteria of the species S. epidermidis is increased after daily topical application of the composition over a period of 2-4 weeks. Preferably, the number of S. epidermidis is increased by at least 2.5%, by at least 5%, by at least 7.5%, by at least 10%, by at least 12.5%, or by at least 15% relative to an untreated areal of the part of the body.
- compositions of the invention are useful for therapeutic purposes, in particular for preventing or treating skin diseases like acne.
- the invention provides a skin care composition as defined hereinabove for use in a method of treating a skin disease, preferably acne.
- the skin care composition is used for preventing the formation of acne.
- the skin care composition is used for treating an acute state of acne.
- the skin care composition is used for preventing the reoccurrence of acne in a subject who has received a standard acne treatment. It is particularly preferred that the subject is a human.
- the invention also provides methods for treating the skin of a subject by administering a skin care composition as described hereinabove.
- a method of treating a skin disease, preferably acne is provided, said method comprising the topical administration of a skin care composition as described hereinabove.
- any of the above compositions of the invention described in detail above can be used for non-therapeutic, cosmetic purposes, e.g. for promoting the development of or stabilizing a healthy skin microbiome, for improving the appearance of the skin of a subject, for maintaining healthy skin, or for promoting bacterial growth of the skin microbiome.
- the present invention also relates to the use, preferably the non- therapeutic use, of a composition comprising
- a carbon source selected from the group consisting of glucose, fructose, saccharose, maltose, maltodextrin, pyruvic acid, pyruvate, lactic acid and/or lactate, and at least one of following components:
- a nitrogen source selected from the group of alanine, glycine, arginine and/or urea;
- the invention also relates to the use, preferably the non-therapeutic use, of a composition comprising a carbon source, which either is glucose, fructose, saccharose, maltose, maltodextrin, pyruvic acid, pyruvate, lactic acid, lactate or a combination of any of these, and at least one additional growth-enhancing compound.
- the additional growth-enhancing compound can be a nitrogen source selected from urea, alanine, glycine and arginine or caprylic/capric triglycerides as a lipid source.
- the composition comprises all three types of components. Accordingly, in a preferred aspect, the invention relates to the use, preferably the non-therapeutic use, of a composition comprising
- the present invention relates to the use, preferably the non-therapeutic use, of a composition
- a composition comprising
- the invention also relates to the use, preferably the non-therapeutic use, of a composition comprising a carbon source, which either is pyruvic acid, pyruvate, lactic acid, lactate or mixtures thereof, e.g. a combination of pyruvate and lactate, and at least one additional growth-enhancing compound.
- the additional growth-enhancing compound can be a nitrogen source selected from urea and arginine or caprylic/capric triglycerides as a lipid source.
- the composition comprises all three types of components. Accordingly, in a preferred aspect, the invention relates to the use, preferably the non- therapeutic use, of a composition comprising
- the present invention also relates to the use, preferably the non-therapeutic use, of a composition
- a carbon source selected from the group consisting of pyruvic acid, pyruvate, lactic acid lactate,
- a nitrogen source selected from the group consisting of urea and arginine;
- caprylic/capric triglycerides for promoting the development of or stabilizing a healthy skin microbiome or for promoting bacterial growth of the skin microbiome.
- pyruvic acid, pyruvate or a mixture thereof is used as a carbon source for promoting the development of or stabilizing a healthy skin microbiome or for promoting bacterial growth of the skin microbiome.
- the pyruvate can be, for example, calcium or sodium pyruvate.
- the pyruvic acid, pyruvate or a mixture thereof is used in combination with urea and/or arginine as a nitrogen source for promoting the development of or stabilizing a healthy skin microbiome or for promoting bacterial growth of the skin microbiome.
- the pyruvic acid, pyruvate or a mixture thereof is used in combination with urea and/or arginine as a nitrogen source and caprylic/capric triglycerides as a lipid source for promoting the development of or stabilizing a healthy skin microbiome or for promoting bacterial growth of the skin microbiome.
- lactate is used as a carbon source for promoting the development of or stabilizing a healthy skin microbiome or for promoting bacterial growth of the skin microbiome.
- the lactate can be, for example, calcium or sodium lactate.
- the lactate is used in combination with urea and/or arginine as a nitrogen source for promoting the development of or stabilizing a healthy skin microbiome or for promoting bacterial growth of the skin microbiome.
- the lactate is used in combination with urea and/or arginine as a nitrogen source and caprylic/capric triglycerides as a lipid source for promoting the development of or stabilizing a healthy skin microbiome or for promoting bacterial growth of the skin microbiome.
- Figure 1 shows the results from in vitro studies for promoting bacterial cell growth. It can be seen that the addition of pyruvate or lactate as a carbon source, either alone or in combina- tion with a nitrogen source and/or a lipid source, induced a significant growth of S. epidermidis within 24 hours.
- Figure 2 shows further results from in vitro studies for promoting bacterial cell growth. It can be seen that the addition of pyruvate, either alone or in combination with arginine, resulted in a significant growth of S. epidermidis within 24 hours.
- Figure 3 shows the results from the analysis of skin hydration and cell count in a volunteer study. More specifically, Figure 3A shows the results from measuring skin hydration with a corneometer after application of compositions of the invention to the thigh skin for four weeks in an in vivo study. Figure 3B shows the results of the cell count measurements from the same study. It can be seen that the compositions of the invention led to significant skin hydration both after 2 and 4 weeks. Also, the compositions led to an increase in the cell number in the microbiome.
- Figure 4 shows the results from 16S amplicon sequencing after applying the composition of the invention in vivo. No changes in the alpha and beta diversity were observed between the treatment group and the control group.
- Results The results can be shown in Figures 1 and 2. It can be taken from these figures that the addition of pyruvate or lactate to the low nutrient medium significantly promotes the growth of S. epidermidis within the 24 hours test period. The growth of the organism can even be further promoted by adding urea, argine or capryl ic/capric triglycerides to the pyruvate or lactate.
- a carrier lotion was prepared to which the test compounds, i.e. the compounds identified as growth-enhancing in the in vitro assays of Example 1 , were added.
- composition of the carrier lotion is described in the following table.
- Table 1 Composition of the carrier lotion
- the test formulations were prepared by mixing the compounds to be tested into the carrier lotion.
- the test formulations were composed as follows:
- Formulation 20 Carrier lotion + 1% urea, 0.3% pyruvate, 1% caprylic/capric triglycerides
- Formulation 30 Carrier lotion + 1% urea, 1% sodium Lactate
- Formulation 40 Carrier lotion + 1% urea, 1% sodium Lactate, 1% caprylic/capric triglycerides
- test areas were marked on the thighs of each participant (01 untreated control I test formulation 201 test formulation 301 test formulation 40).
- the above test formulations were applied two times a day within the marked areas of the thighs in the morning and evening by the test person at home. After 2 weeks and after 4 weeks, the hydration of the skin in the test areas was measured and samples of the microbiome were collected by swabbing on the thighs.
- microbiome samples obtained from the in vivo study of Example 2 were analyzed by microbial colony count and bacterial diversity via 16S rRNA amplicon sequencing.
- the tested skin areal was analyzed by measuring skin hydration.
- test site was rinsed with swabs (FLOQSwabs, Hain Lifescience GmbH, Nehren, Germany) by 3 x 10 lanes using 2 ml rinsing buffer (12,49 g/L Na 2 HPO ; 0,63 g/L KH 2 PO 4 in molecular grade H 2 O) in 15 ml Falcon tubes.
- swabs FLOQSwabs, Hain Lifescience GmbH, Nehren, Germany
- 2 ml rinsing buffer (12,49 g/L Na 2 HPO ; 0,63 g/L KH 2 PO 4 in molecular grade H 2 O) in 15 ml Falcon tubes.
- the sample material was then plated within 60 minutes after collection on Columbia-Sheep-Blood-Tween (COST) agar plates and subsequently incubated.
- COST Columbia-Sheep-Blood-Tween
- Results The results of skin hydration measurements are depicted in Figure 3. As can be seen in Figure 3A, the test formulations provide for a significant skin hydration both after 2 and 4 weeks. In addition, as shown in Figure 3B, the test formulations led to significant increase in the cell count. Figure 4 shows the results from 16S amplicon sequencing. No evident changes in the alpha and beta diversity were observed between the treatment group and the control group. Accordingly, the test formulations stabilize the skin microbiome and promote growth of the bacteria in the skin microbiome without changing the composition of the microbiome.
- results The results of the in vitro growth tests is depicted in the below tables 2 and 3. It can be seen in Table 2 that the carbon sources glucose, fructose, saccharose, maltose, maltodextrin, pyruvate and lactate support the growth of S. epidermidis. Further, Table 3 shows that also the combination of the carbon source pyruvate with nitrogen sources like urea, alanine (Ala) and arginine (Arg) supports growth. In addition, a combination of the carbon source pyruvate or lactate with caprylic/capric triglycerides (FettK12) supports growth.
- Formula A contained a ginger compound (Zingiber officinale root juice) as an additional additive.
- Formula B contained hydrolyzed milk protein as an additional additive. Both formulas were tested and turned out to be highly suitable for shower applications.
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Abstract
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Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
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EP21782526.4A EP4217077A1 (en) | 2020-09-22 | 2021-09-22 | Composition for promoting the skin microbiome |
BR112023005226A BR112023005226A2 (en) | 2020-09-22 | 2021-09-22 | COMPOSITION TO PROMOTE THE SKIN MICROBIOME |
CN202180063429.3A CN116322624A (en) | 2020-09-22 | 2021-09-22 | Composition for promoting skin microbiota |
US18/245,583 US20230363998A1 (en) | 2020-09-22 | 2021-09-22 | Composition for promoting the skin microbiome |
Applications Claiming Priority (10)
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EP20197602.4 | 2020-09-22 | ||
EP20197604.0 | 2020-09-22 | ||
EP20197604.0A EP3970804A1 (en) | 2020-09-22 | 2020-09-22 | Composition for promoting the skin microbiome |
EP20197602.4A EP3970802A1 (en) | 2020-09-22 | 2020-09-22 | Composition for promoting the skin microbiome |
US17/189,496 | 2021-03-02 | ||
EP21160323.8 | 2021-03-02 | ||
EP21160322.0 | 2021-03-02 | ||
EP21160322.0A EP3970806A1 (en) | 2020-09-22 | 2021-03-02 | Composition for promoting the skin microbiome |
EP21160323 | 2021-03-02 | ||
US17/189,496 US20220087968A1 (en) | 2020-09-22 | 2021-03-02 | Composition for promoting the skin microbiome |
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US17/189,496 Continuation-In-Part US20220087968A1 (en) | 2020-09-22 | 2021-03-02 | Composition for promoting the skin microbiome |
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EP (1) | EP4217077A1 (en) |
CN (1) | CN116322624A (en) |
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WO2024104742A1 (en) * | 2022-11-15 | 2024-05-23 | Unilever Ip Holdings B.V. | Method for inhibiting the growth of microbes |
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US20150118173A1 (en) * | 2012-04-27 | 2015-04-30 | Evonik Industries Ag | Formulation comprising caprylic acid ethanolamide and/or capric acid ethanolamide in combination with an aluminium salt and its use |
WO2017087640A1 (en) * | 2015-11-19 | 2017-05-26 | Baum Marc M | Probiotic treatment of skin diseases, disorders, and infections: formulations, methods and systems |
US20190060193A1 (en) * | 2015-11-15 | 2019-02-28 | Symrise Ag | Reduction of stinging sensation on skin |
-
2021
- 2021-09-22 EP EP21782526.4A patent/EP4217077A1/en active Pending
- 2021-09-22 CN CN202180063429.3A patent/CN116322624A/en active Pending
- 2021-09-22 BR BR112023005226A patent/BR112023005226A2/en unknown
- 2021-09-22 WO PCT/EP2021/076117 patent/WO2022063857A1/en unknown
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US20150118173A1 (en) * | 2012-04-27 | 2015-04-30 | Evonik Industries Ag | Formulation comprising caprylic acid ethanolamide and/or capric acid ethanolamide in combination with an aluminium salt and its use |
US20190060193A1 (en) * | 2015-11-15 | 2019-02-28 | Symrise Ag | Reduction of stinging sensation on skin |
WO2017087640A1 (en) * | 2015-11-19 | 2017-05-26 | Baum Marc M | Probiotic treatment of skin diseases, disorders, and infections: formulations, methods and systems |
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DATABASE GNPD [online] MINTEL; 19 May 2020 (2020-05-19), ANONYMOUS: "Sym-Micro Essence", XP055776740, retrieved from https://www.gnpd.com/sinatra/recordpage/7607177/ Database accession no. 7607177 * |
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Cited By (1)
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WO2024104742A1 (en) * | 2022-11-15 | 2024-05-23 | Unilever Ip Holdings B.V. | Method for inhibiting the growth of microbes |
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EP4217077A1 (en) | 2023-08-02 |
CN116322624A (en) | 2023-06-23 |
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