WO2022063320A1 - 一种抑制呼吸道病毒的组合物及呼吸道病毒防治方法 - Google Patents
一种抑制呼吸道病毒的组合物及呼吸道病毒防治方法 Download PDFInfo
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- A61K31/4164—1,3-Diazoles
- A61K31/4172—Imidazole-alkanecarboxylic acids, e.g. histidine
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4402—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 2, e.g. pheniramine, bisacodyl
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4535—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom, e.g. pizotifen
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Definitions
- the invention belongs to the technical field of biomedicine, and in particular relates to a composition for inhibiting respiratory viruses and a method for preventing and treating respiratory viruses.
- Respiratory viral infectious diseases are one of the common clinical diseases.
- the etiology is complex and the virus variability is large, and it is easy to cause outbreaks in the population.
- viruses that can cause respiratory infections, including RNA viruses and DNA viruses.
- the most common pathogenic viruses include influenza virus, parainfluenza virus, respiratory syncytial virus, adenovirus, Rhinovirus and Corona virus, etc.
- SARS coronavirus SARS coronavirus
- H5N1 human avian influenza virus H5N1 human avian influenza virus
- 2009 new type A H1N1 influenza virus etc.
- New coronavirus pneumonia (Corona Virus Disease 2019, COVID-19), referred to as "new coronary pneumonia”, refers to the pneumonia caused by the 2019 new coronavirus infection.
- the structure of the new coronavirus is composed of a protein coat and a single-stranded RNA that carries genetic material. This simple structure reduces the difficulty of replication of the new coronavirus and increases the spread of the virus, while the single chain makes the new coronavirus more prone to mutation, thereby increasing the difficulty of drug treatment.
- the main transmission routes of the new coronavirus include respiratory droplet transmission, contact transmission, aerosol and fecal-oral transmission. Epidemiological surveys have shown that people of all ages may be infected, but adults are mainly infected, with the elderly and the infirm appearing to be more susceptible.
- Respiratory viral infections are very common clinically, but the corresponding therapeutic drugs are few.
- Commonly used clinical antiviral drugs mainly include oseltamivir, amantadine, ribavirin, ganciclovir, and Chinese herbs containing baicalin or andrographolide.
- the main prevention methods for respiratory virus infection are vaccine prevention, attention to personal hygiene, disinfection of the external environment, etc.
- the inventor believes that the current therapeutic and preventive drugs cannot fully meet the current needs for the treatment of respiratory virus infections, and the development speed of related drugs is far less than the speed of virus transmission and mutation.
- the commonly used disinfection methods include alcohol, 84 disinfectant, etc. Disinfecting the external environment of the human body, such as the surrounding air, hands, feet, etc., has nothing to do with the virus that has entered the human respiratory system, and can only wait for the virus to replicate and develop.
- the object of the present invention is to provide a method for inactivating respiratory viruses to prevent and treat respiratory virus-related diseases, in order to achieve this purpose, the present invention provides the following technical solutions:
- a first aspect of the present invention provides a composition for inhibiting respiratory viruses, wherein acetic acid is used as an active ingredient in the composition.
- the research of the present invention proves that hydrogen ions have an inactivating effect on viruses adhered in the human respiratory tract, and acetic acid, as a weak acid, can provide hydrogen ions with a dose of inactivating respiratory viruses at a tolerated concentration, thereby realizing the inactivation of viruses in the human respiratory tract. It can realize the prevention and treatment effect of respiratory virus infection.
- the composition also includes other adjuvant therapeutic ingredients, such as anti-allergic ingredients, oxygen, ethanol, aromatics (citric acid, etc.), coloring agents, and the like.
- adjuvant therapeutic ingredients such as anti-allergic ingredients, oxygen, ethanol, aromatics (citric acid, etc.), coloring agents, and the like.
- citric acid and ethanol not only help improve the sensory stimulation brought by acetic acid to patients, but also have the effect of assisting sterilization.
- acetic acid is used for treatment
- mixing medical oxygen to increase the blood oxygen concentration of the patient helps to improve the cardiopulmonary function of the patient, thereby increasing the inactivation effect of respiratory viruses
- the fragrance helps to improve the patient's treatment experience.
- a second aspect of the present invention provides an inhalant for inhibiting respiratory viruses, the inhalant comprising the composition of the first aspect.
- the inhalant of the present invention also includes a composition scheme of anti-allergic components. Due to individual differences in patients, different people have different tolerance levels to the above-mentioned components of the composition. For the possibility of drug allergy and to ensure drug safety, the inhalation Anti-allergic ingredients are also included in the formulation.
- a third aspect of the present invention provides a method for preventing and treating respiratory viruses, the method for preventing and treating comprising inhaling the respiratory virus-inhibiting inhalant described in the second aspect.
- acetic acid molecules in the acetic acid steam under high temperature state, acetic acid molecules can be ionized to generate more hydrogen ions, and hydrogen ions are the main virus inactivating substances. It also increased substantially. Therefore, increasing the inhalation temperature of steam as much as possible is more conducive to the inactivation of viruses in the respiratory tract.
- a fourth aspect of the present invention provides a method for preventing and treating novel coronavirus pneumonia, the method comprising the steps described in the method for preventing and treating respiratory viruses in the third aspect.
- the method for treating novel coronavirus pneumonia in addition, in the method for treating novel coronavirus pneumonia provided by the present invention, the method of using the inhalant in combination with a drug against novel coronavirus pneumonia is also included, wherein alpha-interferon and the like can be mixed with the inhalant and passed through inhalation Oral or intravenous injection of other anti-COVID-19 drugs while being treated by inhalation.
- the fifth aspect of the present invention provides the use of the composition of the first aspect for inhibiting fungi and/or bacteria in vitro.
- composition provided by the present invention can also be applied to inhibit fungi and bacteria in vitro and in the respiratory tract, and prevent and control fungi or bacteria from adhering to the surface of the skin or respiratory tract to cause diseases.
- the prevention method for respiratory fungi and bacteria is the same as that of the third aspect.
- the high-temperature medicinal liquid vapor described in the second aspect can be fumigated on the skin surface.
- compositions and inhalants provided by the invention also have a good killing effect on viruses entering the respiratory system, can be used for prevention and treatment, and can also be used for environmental disinfection. It has been verified by experiments that using this method for disinfection once a day for about 3 minutes will not be infected with the new coronavirus; those who have been infected with the new coronavirus in the early stage will recover within 4 days by using this method.
- the cost of the inhalant mentioned in the present invention is extremely low. According to the current price level, only 0.1 yuan per person per day can be guaranteed not to be infected, and each patient can be cured with less than 10 yuan.
- the inhalation disinfection method mentioned in the present invention has no toxic and side effects on the human body. After killing the virus, high-temperature hydrogen ions in the human body can be lowered to the normal body temperature in about 0.1 seconds, and form weakly acidic acetic acid with acetate ions, which is excreted with sputum.
- the present invention proposes an inhalant for inhibiting respiratory viruses and a treatment method.
- a first aspect of the present invention provides a composition for inhibiting respiratory viruses, wherein acetic acid is an active ingredient in the composition.
- the effects of inhibiting respiratory viruses in the present invention include directly inhibiting or killing viruses, reducing virus activity, interfering with virus adsorption, preventing virus from entering cells, inhibiting virus transcription, replication process, or inhibiting virus release.
- the state in which the acetic acid exerts the activity of inhibiting respiratory viruses is a steam state, specifically, a high-temperature steam state of an acetic acid solution; that is, in the composition, the active ingredient that inhibits respiratory viruses is the high-temperature steam of an acetic acid solution.
- composition in the present invention is administered by inhalation, and based on this administration method, the above-mentioned composition can directly act on the viruses adhered to the surfaces of the respiratory tract and oral mucosa, and has a direct inactivation effect.
- the sterilization effect of the virus in the inner layer and the interlayer is better.
- the temperature when the steam acts on the virus is 50°C and above.
- the composition further includes one or a mixture of citric acid, ethanol and oxygen.
- the oxygen is medical oxygen.
- the composition includes acetic acid.
- the composition includes acetic acid and citric acid.
- the composition includes acetic acid and an anti-allergic agent.
- the composition includes acetic acid, an anti-allergic agent, and oxygen.
- the composition includes acetic acid, an anti-allergic agent, oxygen, and a fragrance.
- the composition includes acetic acid, an anti-allergic agent, oxygen, a fragrance, and a colorant.
- the composition includes acetic acid and ethanol.
- the composition includes acetic acid, oxygen and ethanol.
- the fragrance in a feasible embodiment of the fragrance, is citric acid, lemon juice, strawberry essence, apple essence and other food additives, and the citric acid is usually used for food preservation and
- the additive in the technical solution of the present application, not only has the effect of citric acid, auxiliary inactivation of viruses and bacteria, but also can help improve the sensory stimulation brought by acetic acid to the patient.
- a composition with better effect provided by the present invention is a mixed solution of acetic acid and citric acid. In the mixed solution, the concentration of acetic acid is 0.01% to 10% (mass fraction), and the concentration of citric acid is 0.01% ⁇ 10% (mass fraction).
- the composition further includes anti-inflammatory drugs, antiviral drugs and/or immunomodulatory drugs, and the like.
- a second aspect of the present invention provides an inhalant for inhibiting respiratory viruses, the inhalant comprising the composition of the first aspect.
- the inhalant includes an acetic acid solution, and the concentration of the acetic acid solution is 0.01% to 10% (mass fraction).
- the inhalant includes a mixed solution of acetic acid and citric acid, and in the mixed solution, the concentration of acetic acid is 0.01%-10% (mass fraction), and the concentration of citric acid is 0.01%-10% (quality score).
- the inhalant includes a mixed solution of acetic acid and ethanol, and in the mixed solution, the concentration of acetic acid is 0.01%-10% (mass fraction), and the concentration of ethanol is 0.01%-10% ( quality score).
- the inhalant also includes oxygen.
- the inhalant is high temperature steam and oxygen of an aqueous acetic acid solution.
- the high-temperature steam and oxygen of the aqueous acetic acid solution in the inhalant are not mixed with each other, and are inhaled according to a certain order of use.
- the steam and oxygen of the acetic acid aqueous solution are mixed according to a certain volume ratio, and are inhaled for use at the same time.
- the inhalant is acetic acid, high temperature steam of ethanol aqueous solution and oxygen.
- the high-temperature steam of the acetic acid and the ethanol aqueous solution and oxygen are not mixed with each other, and are inhaled according to a certain order of use.
- the high-temperature steam of the acetic acid and ethanol aqueous solution is mixed with oxygen in a certain volume ratio, and inhaled together for use.
- the inhaler further includes anti-allergic ingredients.
- the anti-allergic ingredients include antihistamine drugs, allergic reaction mediator blocking-release drugs, histamine desensitizing drugs, leukotriene receptor antagonists, drugs that inhibit antigen-antibody reaction, and drugs that improve or control allergic symptoms.
- antihistamines include but are not limited to diphenhydramine, promethazine, chlorpheniramine and the like.
- the allergic reaction mediator inhibiting drug release includes but is not limited to sodium cromoglycate, ketotifen and the like.
- histamine desensitizing drug includes but is not limited to betahistine, low-dose histamine diluent, dust mite injection and the like.
- leukotriene receptor antagonists include but are not limited to montelukast, zalustre and the like.
- drugs that inhibit the antigen-antibody reaction are such as adrenal glucocorticoids, immunosuppressants and the like.
- the drugs for improving or controlling allergic symptoms include but are not limited to smooth muscle antispasmodics, such as salbutamol, etc.; including drugs for reducing edema caused by allergy, such as calcium gluconate and the like.
- the anti-allergic component is added to the acetic acid and ethanol aqueous solution according to the clinical concentration.
- the leukotriene receptor antagonists - montelukast, zalustre, etc. are more suitable for respiratory allergies, so they are added to the inhaler as a more preferred component.
- the high-temperature steam of the aqueous solution of acetic acid, ethanol and the antiallergic agent is mixed with oxygen according to a certain volume ratio and used together for inhalation.
- a third aspect of the present invention provides a method for preventing and treating respiratory viruses, the method for preventing and treating comprising inhaling the respiratory virus-inhibiting inhalant described in the second aspect.
- the respiratory viruses include but are not limited to rhinovirus, coronavirus, enterovirus, adenovirus, and respiratory syncytial virus.
- the coronaviruses include but are not limited to SARS-CoV and 2019-nCoV.
- the inhalation temperature of the inhalant is a relatively high temperature that can be tolerated by the human body. It is verified by the present invention that the inhalation temperature of the inhalant is 50° C. and above.
- the use of the inhalant is as follows: the inhalant that is a liquid part at room temperature is heated and boiled to generate steam, and the patient needs to continue to inhale the steam for a period of time, and the temperature should be kept at 50 ° C and above when the steam is inhaled, so that The high temperature that the human body can tolerate is the upper limit.
- the inhalation time of the steam is 1-20 min/day.
- the concentration of acetic acid is determined according to the patient's tolerance. It is recommended to use 0.01-2% acetic acid solution for children and elderly patients, and 0.5% to 5% for adult patients. Acetic acid solution is the best treatment.
- the inhalant is a mixed aqueous solution of acetic acid and ethanol, wherein the ratio of acetic acid to ethanol is 1:0.1-2.
- the inhalant is an acetic acid aqueous solution
- the acetic acid aqueous solution is heated to boiling, and the patient continues to inhale the acetic acid aqueous solution vapor above 50°C for 1-10 minutes for treatment.
- the inhalant is an aqueous solution of acetic acid and citric acid, and the aqueous solution of acetic acid and citric acid is heated to boiling. treat.
- the inhalant is an aqueous solution of acetic acid and ethanol
- the acetic acid and the aqueous ethanol solution are heated to boiling, and the patient continues to inhale the vapor of acetic acid and aqueous ethanol solution above 50°C for 5 to 10 minutes for treatment
- the mass ratio of acetic acid and ethanol is 1:1.
- the oxygen also includes oxygen inhalation for adjuvant therapy.
- the oxygen uses medical oxygen.
- the patient inhales the steam and the oxygen for a period of time, or mixes the steam and the oxygen before inhaling.
- the prevention and treatment method further includes cooperating with other drug treatments, including but not limited to neuraminidase inhibitors, steroidal anti-inflammatory drugs, non-steroidal anti-inflammatory drugs, antibiotics, immune stimulants , immunomodulators, nucleoside antiviral agents, nucleotide antiviral agents, anti-fibrotic drugs, caspase inhibitors, creatinine 5'-monophosphate dehydrogenase inhibitors and viral enzyme inhibitors, etc. .
- other drug treatments including but not limited to neuraminidase inhibitors, steroidal anti-inflammatory drugs, non-steroidal anti-inflammatory drugs, antibiotics, immune stimulants , immunomodulators, nucleoside antiviral agents, nucleotide antiviral agents, anti-fibrotic drugs, caspase inhibitors, creatinine 5'-monophosphate dehydrogenase inhibitors and viral enzyme inhibitors, etc.
- the other medicines include but are not limited to chemotherapy drugs, Chinese patent medicines or traditional Chinese medicines; the traditional Chinese medicines are preferably Chinese medicine decoctions, which can be used for fumigation together with the composition of the first aspect.
- a fourth aspect of the present invention provides a method for preventing and treating novel coronavirus pneumonia, the method comprising the steps described in the method for preventing and treating respiratory viruses in the third aspect.
- the prevention method is applied to the prevention or treatment of novel coronavirus pneumonia.
- the method of combined use with anti-novel coronavirus pneumonia drugs includes but not limited to alpha-interferon, lopinavir, ritonavir , ribavirin, favipiravir, chloroquine phosphate, or remdesivir.
- the spread of the new coronavirus often enters the body of the host by adhering to the eyes, nose, mouth, hands and other parts of the human body to cause disease.
- the method of the present invention can well disinfect the difficult-to-sterilize parts such as the eyes, nose, and mouth, and the user only needs to The face is close to the steam of acetic acid solution and inhaled for a period of time, and the comprehensive disinfection effect on the eyes, nose and mouth can be realized.
- the fifth aspect of the present invention provides the use of the composition of the first aspect for inhibiting fungi and/or bacteria in vitro.
- the external body includes a skin surface and a cavity surface communicating with the outside world; further preferably, the external body includes a skin surface and a respiratory tract.
- the fungi include superficial bacillus fungi commonly found on the skin surface, such as Trichophyton, Epidermophyton, Microsporum, etc.; also include deep infection fungi, such as Candida, Cryptococcus neoformans, etc.; also include Fungal infections of other lung systems, such as Pneumocystis spp.
- the bacteria are preferably respiratory bacteria, including but not limited to Mycobacterium tuberculosis, Corynebacterium diphtheriae, Legionella pneumophila, Haemophilus influenzae, Bordetella pertussis, Mycoplasma pneumoniae, Chlamydia pneumoniae or a mixture of several.
- an inhalant for inhibiting respiratory viruses is provided, the inhalant is a 2% acetic acid solution, and the inhalation is used in the following manner: the inhalant is heated to boiling, and the patient needs to take turns inhaling the inhalant.
- the steam and fresh air produced by boiling, and the temperature of the steam should be kept above 50 °C when inhaling, and the steam with a higher temperature should be inhaled as much as possible within the range that the patient can tolerate.
- the number of treatments used to prevent respiratory viruses is once a day, and each inhalation time is 3 minutes.
- the number of treatments used to treat diseases caused by respiratory viruses is 3 to 6 times a day, and the recommended time for each inhalation is 5 minutes.
- an inhalant for inhibiting respiratory viruses is provided, the inhalant is a 2% mixed aqueous solution of acetic acid and citric acid, (the concentrations of acetic acid and citric acid are both 2%) the use of the inhalation
- the method is as follows: the inhalant is heated to boiling, and the patient needs to take turns inhaling the steam generated by the boiling and fresh air, and the temperature of the steam should be kept above 50°C during inhalation.
- the number of treatments used to prevent respiratory viruses is once a day, and each inhalation time is 3 minutes.
- the number of treatments used to treat diseases caused by respiratory viruses is 3 to 6 times a day, and the recommended time for each inhalation is 5 minutes.
- an inhalant for inhibiting respiratory viruses is provided, the inhalant is a mixed aqueous solution of 2% acetic acid and ethanol, (the concentrations of acetic acid and ethanol are both 2.5%), and the inhalation is used in the following manner : The inhalant is heated to boiling, and the patient needs to take turns inhaling the steam generated by the boiling and fresh air, and the temperature of the steam should be kept above 50°C during inhalation.
- the number of treatments used to prevent respiratory viruses is once a day, and each inhalation time is 3 minutes.
- the number of treatments used to treat diseases caused by respiratory viruses is 3 to 6 times a day, and the recommended time for each inhalation is 5 minutes.
- an inhalant for suppressing respiratory viruses is provided.
- the usage is as follows: the inhalant is heated to boiling, the patient needs to inhale the steam and medical oxygen mixture produced by the boiling for a period of time, and the temperature of the steam should be kept above 50°C during inhalation.
- the number of treatments used to prevent respiratory viruses is once a day, and the time of each inhalation of steam is 3 minutes.
- the number of treatments used to treat diseases caused by respiratory viruses is 3 to 6 times a day, and the recommended time for each inhalation of steam is 5 minutes.
- an inhalant for preventing and treating new coronary pneumonia is provided, the inhalant is 2% acetic acid, ethanol mixed aqueous solution and medical oxygen, (the concentrations of acetic acid and ethanol are both 2%) the use of the inhalation
- the method is as follows: the inhalant is heated to boiling, the patient needs to take turns inhaling the steam generated by the boiling and the medical oxygen, and the temperature of the steam should be kept above 50°C during inhalation.
- the number of treatments for the prevention of new coronary pneumonia is once a day, and the time for each inhalation of steam is 3 minutes.
- the number of treatments for the treatment of new coronary pneumonia is 3 to 6 times a day, and the recommended time for each inhalation of steam is 5 minutes.
- a method for treating new coronary pneumonia is provided, which is different from the description in Embodiment 4 in that, in this embodiment, aerosolized alpha-interferon is also inhaled at the same time.
- an inhalant for preventing and treating new coronary pneumonia is provided, the inhalant is 2.5% acetic acid, ethanol, montelukast mixed aqueous solution and medical oxygen, (the concentrations of acetic acid and ethanol are both 2.5%)
- the inhalation is used as follows: the inhalant is heated to boiling, the patient needs to take turns inhaling the steam generated by the boiling and medical oxygen, and the temperature of the steam should be kept above 50°C during inhalation.
- the number of treatments for the prevention of new coronary pneumonia is once a day, and the time for each inhalation of steam is 3 minutes.
- the number of treatments for the treatment of new coronary pneumonia is 3 to 6 times a day, and the recommended time for each inhalation of steam is 5 minutes.
- an inhalant for preventing and treating bacterial and fungal infections of the respiratory tract is provided. 2.5%)
- the inhalation is used as follows: the inhalant is heated to boiling, the patient needs to take turns inhaling the steam generated by the boiling and medical oxygen, and the temperature of the steam should be kept above 50°C during inhalation.
- the number of treatments used to prevent bacterial and fungal infections is once a day, and the time for each inhalation of steam is 3 minutes.
- the number of treatments for bacterial and fungal infections is 3 to 6 times a day, and the recommended time for each inhalation of steam is 5 minutes.
- the inventor recruited 20 influenza patients as volunteers, and used the treatment method described in Example 1 for treatment. 3 days was a course of treatment, the cure rate was 100%, and the cure time was one course of treatment. Among them, the body temperature of patients with high fever can be reduced to normal levels on the second day of treatment.
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Abstract
Description
Claims (10)
- 一种用于抑制呼吸道病毒的组合物,其特征在于,所述组合物中乙酸作为活性成分;优选的,所述组合物中,抑制呼吸道病毒的活性成分为乙酸溶液的高温蒸汽;进一步优选的,所述蒸汽作用于病毒时的温度为50℃及以上。
- 如权利要求1所述用于抑制呼吸道病毒的组合物,其特征在于,所述组合物中还包括乙醇、氧气中的一种或其混合物;优选的,所述氧气为医用氧气;进一步的,所述组合物包括乙酸;或,所述组合物包括乙酸及抗过敏剂;或,所述组合物包括乙酸、抗过敏剂及氧气;或,所述组合物包括乙酸、抗过敏剂、氧气及芳香剂;或,所述组合物包括乙酸、抗过敏剂、氧气、芳香剂及着色剂;或,所述组合物中包括乙酸及乙醇;或,所述组合物中还包括抗炎药物、抗病毒药物、免疫调节药物。
- 一种用于抑制呼吸道病毒的吸入剂,其特征在于,所述吸入剂包括权利要求1-2任一项所述组合物。
- 如权利要求3所述用于抑制呼吸道病毒的吸入剂,其特征在于,所述吸入剂中包括乙酸溶液,所述乙酸溶液的浓度为0.01%~10%;或,所述吸入剂为一种乙酸、乙醇混合溶液溶液,所述混合溶液中,乙酸的浓度为0.01%~10%,所述乙醇的浓度为0.01%~10%。
- 如权利要求4所述用于抑制呼吸道病毒的吸入剂,其特征在于,所述吸入剂为乙酸溶液及氧气;优选的,所述吸入剂为乙酸水溶液的蒸汽及氧气;进一步的,所述吸入剂中乙酸水溶液的蒸汽及氧气互不掺杂,按照一定的使用次序吸入;进一步的,所述乙酸水溶液的蒸汽及氧气按照一定的体积比混合,同时吸入使用。
- 如权利要求4所述用于抑制呼吸道病毒的吸入剂,其特征在于,所述吸入剂中还包括抗过敏成分;优选的,所述抗过敏成分包括抗组胺药物、过敏反应介质阻释药、组胺脱敏药、白三烯受体拮抗剂、抑制抗原抗体反应药物、改善或控制变态反应症状的药物;进一步优选的,所述抗组胺药物包括但不限于苯海拉明、异丙嗪及氯苯那敏;进一步优选的,所述过敏反应介质阻释药包括但不限于色甘酸钠,酮替芬;进一步优选的,所述组胺脱敏药包括但不限于倍他司汀、小剂量组胺稀释液、粉尘螨注射液;进一步优选的,所述白三烯受体拮抗剂包括但不限于孟鲁斯特、扎鲁斯特;进一步优选的,所述抑制抗原抗体反应药物如肾上腺糖皮质激素、免疫抑制剂;进一步优选的,所述改善或控制变态反应症状的药物,包括但不限于平滑肌解痉药,如沙丁胺;以及减轻过敏所致水肿的药物,如葡萄糖酸钙。
- 一种呼吸道病毒防治方法,其特征在于,所述防治方法包括 吸入权利要求3-6任一项所述抑制呼吸道病毒的吸入剂;优选的,所述呼吸道病毒包括但不限于鼻病毒、冠状病毒、肠道病毒、腺病毒、呼吸道合胞病毒;进一步的,所述冠状病毒,包括但不限于SARS-CoV、2019-nCoV;优选的,所述吸入剂的吸入温度为50℃及以上;进一步的,所述吸入剂的使用方式如下:将常温下为液态部分的吸入剂加热沸腾至产生蒸汽,患者需要持续吸入该蒸汽一段时间,所述蒸汽温度应当保持在50℃及以上,以人体能够耐受的高温为上限;进一步的,所述蒸汽的吸入时间为1~20min/天;更进一步的,所述吸入剂中,乙酸的浓度视患者耐受情况确定,儿童和老年患者采用0.01~2%的乙酸溶液,成年患者采用0.5%~5%浓度的乙酸溶液治疗;更进一步的,所述吸入剂为乙酸、乙醇的混合水溶液,其中乙酸与乙醇的比例为1:0.1~2。
- 如权利要求7所述呼吸道病毒防治方法,其特征在于,所述防治方法中,还包括同时采用其他药物配合治疗,所述其他药物包括但不限于神经氨酸酶抑制剂、甾体抗炎药物、非甾体抗炎药物、抗生素、免疫刺激剂、免疫调节剂、核苷类抗病毒剂、核苷酸类抗病毒剂、抗纤维化药物、半胱天冬酶抑制剂、肌酐5’-单磷酸脱氢酶抑制剂和病毒酶抑制剂;优选的,所述其他药物包括但不限于化疗药物、中成药或中药;所述中药优选中药汤剂,可与权利要求1或2所述组合物共同进行熏蒸 使用。
- 一种新型冠状病毒肺炎的防治方法,其特征在于,所述方法包括权利要求7或8所述呼吸道病毒防治方法所记载的步骤;优选的,所述防治方法应用于对新型冠状病毒肺炎的预防或治疗;优选的,所述防治方法中,还包括与抗新型冠状病毒肺炎的药物联合使用的方式,所述抗新型冠状病毒的药物包括但不限于α-干扰素,洛匹那韦、利托那韦、利巴韦林、法匹拉韦、磷酸氯喹或瑞德西韦。
- 权利要求1或2所述组合物在抑制体外真菌和/或细菌中的应用;优选的,所述体外包括皮肤表面及与外界连通的腔道表面;进一步优选的,所述体外包括皮肤表面及呼吸道;所述真菌包括毛癣菌属、表皮癣菌属及小孢子癣菌属;还包括假丝酵母菌、新生隐球菌、肺孢子菌属;所述细菌优选呼吸道细菌,包括但不限于结核分枝杆菌、白喉棒状杆菌、嗜肺军团菌、流感嗜血杆菌、百日咳鲍特菌、肺炎支原体、肺炎衣原体中的一种或几种的混合。
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