WO2022062909A1 - 冰箱 - Google Patents

冰箱 Download PDF

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Publication number
WO2022062909A1
WO2022062909A1 PCT/CN2021/117433 CN2021117433W WO2022062909A1 WO 2022062909 A1 WO2022062909 A1 WO 2022062909A1 CN 2021117433 W CN2021117433 W CN 2021117433W WO 2022062909 A1 WO2022062909 A1 WO 2022062909A1
Authority
WO
WIPO (PCT)
Prior art keywords
sample
microfluidic
detection
detection system
refrigerator
Prior art date
Application number
PCT/CN2021/117433
Other languages
English (en)
French (fr)
Inventor
刘浩泉
费斌
赵斌堂
王晶
Original Assignee
青岛海尔电冰箱有限公司
海尔智家股份有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 青岛海尔电冰箱有限公司, 海尔智家股份有限公司 filed Critical 青岛海尔电冰箱有限公司
Priority to EP21871281.8A priority Critical patent/EP4206588A4/en
Priority to US18/246,465 priority patent/US11813611B2/en
Publication of WO2022062909A1 publication Critical patent/WO2022062909A1/zh

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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F25—REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
    • F25D—REFRIGERATORS; COLD ROOMS; ICE-BOXES; COOLING OR FREEZING APPARATUS NOT OTHERWISE PROVIDED FOR
    • F25D23/00—General constructional features
    • F25D23/02—Doors; Covers
    • F25D23/028—Details
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F25—REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
    • F25D—REFRIGERATORS; COLD ROOMS; ICE-BOXES; COOLING OR FREEZING APPARATUS NOT OTHERWISE PROVIDED FOR
    • F25D23/00—General constructional features
    • F25D23/12—Arrangements of compartments additional to cooling compartments; Combinations of refrigerators with other equipment, e.g. stove
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N21/78—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a change of colour
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/04—Exchange or ejection of cartridges, containers or reservoirs
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0689—Sealing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/16—Reagents, handling or storing thereof
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0819—Microarrays; Biochips
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0877—Flow chambers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0883—Serpentine channels
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F25—REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
    • F25D—REFRIGERATORS; COLD ROOMS; ICE-BOXES; COOLING OR FREEZING APPARATUS NOT OTHERWISE PROVIDED FOR
    • F25D2323/00—General constructional features not provided for in other groups of this subclass
    • F25D2323/02—Details of doors or covers not otherwise covered
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N2021/7756—Sensor type
    • G01N2021/7763—Sample through flow
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N2035/00465—Separating and mixing arrangements
    • G01N2035/00524—Mixing by agitating sample carrier

Definitions

  • the invention relates to refrigeration and freezing technology, in particular to a refrigerator.
  • the existing detection systems generally exist independently, take up space, and are inconvenient to store. After the detection device is stored, it will be forgotten to be used, or it will not be taken out for use because it is troublesome. For this reason, in the prior art, a detection system for pesticide residue detection is integrated into the refrigerator compartment or an additional pesticide residue detection chamber is provided in the storage space of the refrigerator. No matter which solution is adopted, it will occupy more storage space. , affecting the user experience.
  • One object of the present invention is to overcome at least one defect of the prior art, and to provide a refrigerator with a microfluidic detection system, and the microfluidic detection system does not occupy the original storage space.
  • a further object of the present invention is to maintain the good thermal insulation performance of the refrigerator, and to improve the operation convenience of the user using the microfluidic detection system.
  • Another further object of the present invention is to facilitate the assembly and disassembly of the microfluidic detection system.
  • the present invention provides a refrigerator, comprising:
  • a box body which defines a storage space for storing items
  • a door connected to the box and used to open and/or close the storage space
  • a microfluidic detection system arranged on the door body, includes:
  • a microfluidic biochip has an injection port, a communication port, and a detection pool formed therein, wherein the injection port, the detection pool, and the communication port are sequentially communicated through a microfluidic channel, thereby allowing The sample liquid in contact with the injection port enters the microfluidic channel and flows into the detection cell through the microfluidic channel;
  • a detection mechanism is used to detect the detection cell to obtain preset detection parameters of the sample liquid.
  • the microfluidic detection system further includes:
  • a housing on which is formed an operating table open towards its front side, the sample table being at least partially located in the operating table.
  • a hollow window is opened on the front side of the door body, and the operating table is exposed to the front side of the door body through the hollow window.
  • the door body includes a panel for forming its front, a door lining for forming its rear, and a foam insulation layer disposed between the panel and the door lining, and the hollow window opening on said panel; and
  • a pre-embedded box is pre-embedded between the panel and the door liner before the foam insulation layer is formed, and the microfluidic detection system is arranged in the pre-embedded box.
  • the pre-embedded box is attached to the rear surface of the panel, and the front side of the pre-embedded box is open and faces the hollow window, so as to allow the microfluidic detection system to pass through the
  • the hollow window is installed in the pre-embedded box from front to back.
  • the housing is provided with a first structural connector for connecting with the pre-embedded box, and for forming an electrical connection between the microfluidic detection system and the electronic control device of the refrigerator a first electrical connector to allow the microfluidic detection system to be mounted to the door as a whole;
  • the pre-embedded box is provided with a second structural connector that is matched with the first structural connector and a second electrical connector that is electrically connected to the first electrical connector, and the second electrical connector is connected to the first electrical connector.
  • the electronic control device is electrically connected.
  • the microfluidic biochip is disposed above the sample stage, and the injection port is located at the bottom of the microfluidic biochip;
  • the sample stage is configured to be controlled or operable to move up and down so that the sample stage is in a detection position and in a detection position that allows a sample liquid in a sample cup placed on the sample stage to come into contact with the injection port. Switch between initial positions at a preset distance below the detection position.
  • the microfluidic biochip is removably above the sample stage, and the injection port is located at the bottom of the microfluidic biochip;
  • the microfluidic detection system also includes:
  • a chip mounting mechanism arranged in the casing, and used for supporting the microfluidic biochip
  • a chip ejection mechanism for operably releasing the support effect of the chip mounting mechanism on the microfluidic biochip, so as to release the microfluidic biochip so that it falls on the sample under the action of its own gravity on stage.
  • the microfluidic detection system further includes:
  • a buffer bottle disposed in the housing, and used for containing the buffer
  • a buffer driving device is arranged in the housing and communicated with the buffer bottle, so as to controllably drive the buffer in the buffer bottle into the sample cup placed on the sample stage, so that all The buffer solution is mixed with the sample in the sample cup to generate a sample solution.
  • the sample stage includes:
  • a shaker disposed on the support table, is used to shake the sample cup after the sample cup is placed on the support table, so that the buffer solution and the sample in the sample cup are fully mixed.
  • the microfluidic detection system further includes:
  • the sample liquid driving device is in sealing communication with the communication port, so as to promote the sample liquid in contact with the sample inlet to flow into the microfluidic channel and flow to the detection cell through the microfluidic channel.
  • the refrigerator of the present invention is provided with a microfluidic detection system, which saves the independent storage of the microfluidic detection system and does not occupy indoor space.
  • refrigerators are very commonly used household appliances, which are convenient and fast for users to randomly use the microfluidic detection system on the refrigerator to perform detection requirements such as pesticide residue detection, nutritional element detection or breast milk detection.
  • the microfluidic detection system is set on the door body, which is not only convenient to operate, but also does not occupy the original storage space in the box, and will not affect the storage capacity of the refrigerator itself.
  • the shell of the microfluidic detection system is formed with a front-opening operating table, the sample table is located in the operating table, the front side of the door body is provided with a hollow window, and the operating table is exposed to the door body through the hollow window of the door body. front side. That is to say, the operating table is exposed, which is convenient for users to perform a series of operations in the operating table without opening the door, such as picking and placing sample cups, replacing microfluidic biochips, etc. On the one hand, it can avoid the The installation of the microfluidic detection system leads to the increase of the door opening frequency and the serious leakage of cold, which ensures the refrigerator has good thermal insulation performance; Ease of operation of the system.
  • the door body is provided with a pre-embedded box
  • the microfluidic detection system has a housing
  • the microfluidic detection system is installed as a whole by arranging corresponding structural connectors and electrical connectors on the pre-embedded box and the housing. to the door body, thereby realizing the connection between the entire microfluidic detection system and the refrigerator in terms of structure and circuit. Therefore, not only the assembling process of the microfluidic detection system is simplified, but also the disassembly or maintenance of the microfluidic detection system is facilitated.
  • FIG. 1 is a schematic structural diagram of a refrigerator according to an embodiment of the present invention.
  • FIG. 2 is a schematic structural diagram of a microfluidic detection system according to an embodiment of the present invention.
  • FIG. 3 is a schematic structural exploded view of a microfluidic detection system according to an embodiment of the present invention.
  • FIG. 4 is a schematic structural diagram of the internal structure of a microfluidic detection system according to an embodiment of the present invention.
  • FIG. 5 is a schematic structural exploded view of the internal structure of a microfluidic detection system according to an embodiment of the present invention.
  • FIG. 6 is a schematic cross-sectional view of a microfluidic biochip according to an embodiment of the present invention.
  • FIG. 7 is a schematic structural exploded view of a door body according to an embodiment of the present invention.
  • FIG. 8 is a schematic structural diagram of the lifting mechanism and the sample stage in an exploded state according to an embodiment of the present invention.
  • FIG. 1 is a schematic structural diagram of a refrigerator according to an embodiment of the present invention.
  • the refrigerator 100 according to the present invention includes a box body 200 and a door body 300 .
  • the box body 200 defines a storage space for storing articles
  • the door body 300 is connected with the box body 200 and is used to open and/or close the storage space thereof.
  • the refrigerator 100 further includes a microfluidic detection system 1 , and the microfluidic detection system 1 is disposed on the door body 300 .
  • the microfluidic detection system 1 is used to qualitatively or quantitatively detect preset detection parameters of the sample liquid, and the preset detection parameters can be, for example, pesticide residues used to indicate whether the pesticide residues exceed the standard and/or specific values of the pesticide residues. parameters, nutritional parameters used to indicate whether the nutrient elements meet the standard and/or specific content of nutrient elements, specific substance parameters used to indicate whether specific harmful substances (such as specific viruses) exceed the standard and/or specific content, and so on.
  • FIG. 2 is a schematic structural diagram of a microfluidic detection system according to an embodiment of the present invention
  • FIG. 3 is a schematic structural exploded view of a microfluidic detection system according to an embodiment of the present invention
  • FIG. 4 is a schematic structural diagram of a microfluidic detection system according to an embodiment of the present invention
  • FIG. 5 is a schematic structural exploded view of the internal structure of the microfluidic detection system according to an embodiment of the present invention.
  • the sample cup 2 is also shown in FIGS. 1 to 5 .
  • the microfluidic detection system 1 may include a microfluidic biochip 10 and a detection mechanism 20 .
  • the preset detection parameters used by the microfluidic detection system for detection are different, the specific selection of the microfluidic biochip 10 and the detection mechanism 20 used by the microfluidic detection system may also be different.
  • the microfluidic biochip 10 it has can be a microfluidic pesticide residue detection chip that can provide detection conditions for the pesticide residue liquid
  • the detection mechanism 20 it has can be It is a pesticide residue testing institution that can detect the pesticide residue parameters of pesticide residue liquid.
  • the microfluidic biochip 10 has a sample inlet 111 formed at an end thereof, a communication port 112, and a detection cell formed inside thereof 121, the sample inlet 111, the detection cell 121, and the communication port 112 are sequentially communicated through the microfluidic channel 14, thereby allowing the sample liquid in contact with the injection port 111 to flow into the microfluidic channel 14 and into the detection pool through the microfluidic channel 14 121.
  • the microfluidic channel 14 referred to in the present invention refers to a microfluidic channel or a capillary channel with a flow area within a predetermined size range, so that it has a suitable ability to retain the liquid therein.
  • the injection port 111 and the communication port 112 may be formed at the end of the microfluidic biochip 10 . Further, the injection port 111 and the communication port 112 are preferably formed at different ends of the microfluidic biochip 10 .
  • the detection mechanism 20 is used to detect the detection cell 121 to obtain preset detection parameters of the sample liquid. Specifically, detection reagents may be pre-installed in the detection cell 121, or the detection reagents may be added to the detection cell 121 manually or automatically, so that the sample liquid in the detection cell 121 reacts with the detection reagents in the detection cell 121 to pass the detection The mechanism 20 detects the detection cell 121 .
  • the refrigerator 100 of the present invention is provided with a microfluidic detection system 1, which omits the independent storage of the microfluidic detection system 1 and does not occupy indoor space.
  • the refrigerator 100 is a very commonly used household appliance, which is convenient and quick for users to randomly use the microfluidic detection system 1 on the refrigerator 100 to perform detection requirements such as pesticide residue detection, nutrient element detection or breast milk detection.
  • the microfluidic detection system 1 is arranged on the door body 300, which is not only convenient to operate, but also does not occupy the original storage space in the box body 200, and does not affect the storage capacity of the refrigerator 100 itself.
  • the microfluidic biochip 10 further includes a reaction cell 122 formed in the interior thereof.
  • the reaction cell 122 is located on the main channel formed by the injection port 111, the detection cell 121, and the communication port 112 connected in sequence, and is connected to the injection port 112. between the port 111 and the detection cell 121 , so that the sample liquid first reacts with the reaction reagent in the reaction cell 122 and then flows into the detection cell 121 .
  • the microchannel 14 communicates between the reaction cell 122 and the sample inlet 111 and between the reaction cell 122 and the detection cell 121 .
  • the reaction reagents and detection reagents for pesticide residue detection can be enzyme reagents and chromogenic reagents, respectively.
  • the reaction cell 122 is used for reacting the sample liquid with the enzyme reagent therein, and the sample liquid reacted with the enzyme reagent flows into the detection cell 121 to react with the color developing agent in the detection cell 121 .
  • the detection mechanism 20 may be selected as a photoelectric detection mechanism, which may include a light source 21 and a photosensitive element 22 respectively disposed on two opposite sides of the microfluidic biochip 10 and facing the detection cell 121, and the light emitted by the light source 21 It is irradiated to the detection cell 121, and the light transmitted through the detection cell 121 is guided into the photosensitive element 22, so as to facilitate the determination of the absorbance change in the detection cell 121 through the light intensity signal received by the photosensitive element 22, and then calculate the pesticide residue inhibition rate. Further, the detection mechanism 20 also includes a heating sheet 24 for providing heat to the detection cell 121 and a thermostat 25 for controlling the heating power of the heating sheet 24 to be constant, so that the sample liquid and detection reagent in the detection cell 121 are sufficient, Respond quickly.
  • a photoelectric detection mechanism which may include a light source 21 and a photosensitive element 22 respectively disposed on two opposite sides of the microfluidic biochip 10 and facing the detection cell 121, and the light emitted by the
  • the microfluidic detection system 1 further includes a sample stage 70 and a housing 80 .
  • the sample stage 70 is used to place the sample cup 2, and the sample cup 2 is used to hold the sample liquid.
  • the housing 80 is formed with an operation table 83 open toward the front side thereof, and the sample table 70 is at least partially located in the operation table 83 , so as to facilitate the user to perform operations such as placing the sample cup 2 and taking out the sample cup 2 in the operation table 83 .
  • the operating table 83 may be provided with a water receiving box 88 under the sample table 70 to receive the liquid that may be dripped, so as to avoid contamination of the operating table 83 .
  • At least some sections of the microfluidic biochip 10 and the detection mechanism 20 are both arranged in the housing 80 .
  • FIG. 7 is a schematic structural exploded view of a door body according to an embodiment of the present invention. Further, referring to FIGS. 1 , 2 and 7 , the front side of the door body 300 is provided with a hollow window 301 , and the operating table 83 is exposed to the front side of the door body 300 through the hollow window 301 . That is to say, the operating table 83 is exposed, which is convenient for the user to perform a series of operations on the operating table 83 without opening the door 300, such as taking and placing the sample cup 2, replacing the microfluidic biochip 10, etc.
  • the problem of serious cold leakage due to the increased opening frequency of the door body 300 caused by the installation of the microfluidic detection system 1 in the refrigerator 100 can be avoided, ensuring that the refrigerator 100 has good thermal insulation performance; on the other hand, the user does not need to open the door when performing the detection operation
  • the door body 300 improves the operational convenience for the user to use the microfluidic detection system 1 .
  • the door body 300 includes a panel 302 for forming its front, a door liner 303 for forming its rear, and a foam insulation layer (not shown in the figure) disposed between the panel 302 and the door liner 303 shown), the hollow window 301 is opened on the panel 302 .
  • a pre-embedded box 304 is pre-embedded between the panel 302 and the door liner 303 before the foam insulation layer is formed, and the microfluidic detection system 1 is arranged in the pre-embedded box 304 .
  • the pre-embedded box 304 is pre-set between the panel 302 and the door liner 303 before the door body 300 is foamed, so as to be reserved between the panel 302 and the door liner 303 for installing microfluidic detection System 1 space.
  • the pre-embedded box 304 is attached to the rear surface of the panel 302 , and the front side of the pre-embedded box 304 is open and faces the hollow window 301 , so as to allow the microfluidic detection system 1 to pass through the hollow window 301 from front to back.
  • the installation into the pre-embedded box 304 improves the convenience of installation of the microfluidic detection system 1 .
  • the casing 80 is provided with a first structural connector 81 for connecting with the pre-embedded box 304 , and a first structural connector 81 for forming an electrical connection between the microfluidic detection system 1 and the electronic control device of the refrigerator 100 .
  • the first electrical connector 82 to allow the microfluidic detection system 1 to be mounted to the door body 300 as a whole.
  • the pre-embedded box 304 is provided with a second structural connector 305 that is matched with the first structural connector 81 and a second electrical connector 306 that is electrically connected to the first electrical connector 82.
  • the second electrical connector 306 is connected to the refrigerator 100.
  • the electrical control device is electrically connected.
  • the microfluidic detection system 1 is installed on the door body 300 as a whole, so as to realize the structure and circuit.
  • the connection between the entire microfluidic detection system 1 and the refrigerator 100 Therefore, not only the assembly process of the microfluidic detection system 1 is simplified, but also the disassembly or maintenance of the microfluidic detection system 1 is facilitated.
  • the microfluidic biochip 10 is disposed above the sample stage 70 , and the injection port 111 is located at the bottom of the microfluidic biochip 10 .
  • the sample stage 70 is arranged to be controlled or operable to move up and down so that the sample stage 70 is pre-positioned in a detection position allowing the sample liquid in the sample cup 2 placed thereon to come into contact with the injection port 111 and below the detection position. Switches between the initial positions of the set distance. Thus, the sample loading of the microfluidic biochip 10 is realized.
  • the sample adding operation is very convenient, saving time and effort.
  • the sample stage 70 by setting the sample stage 70 to be movable, complex structures such as the sample liquid delivery pump, delivery pipeline, sampling needle, etc. are omitted, so that the structure of the microfluidic detection system 1 is very simple, so that it is suitable for use. It is integrated into the refrigerator for easy home use.
  • the initial position is at a preset distance below the detection position, and the sample cup 2 will not interfere with the microfluidic biochip 10 or other structures when placing the sample cup 2, which further improves the convenience and comfort of operation.
  • the microfluidic detection system 1 further includes a lifting mechanism 60 for driving the sample stage 70 to move up and down, so that the sample stage 70 can be automatically switched between the detection position and the initial position. That is, the sample stage 70 can be automatically raised and lowered by the upgrading mechanism 60 .
  • the user When adding samples, the user only needs to place the sample cup 2 on the sample stage 70 when the sample stage 70 is in the initial position, and the lifting mechanism 60 can automatically lift the sample stage 70 to its detection position, without the need for the user to continue to participate. , the automation degree of the microfluidic detection system 1 is improved.
  • the initial position is at a preset distance below the detection position, and the sample cup 2 will not interfere with the microfluidic biochip 10 or other structures when placing the sample cup 2 , which further improves the convenience and comfort of operation.
  • FIG. 8 is a schematic structural diagram of the lifting mechanism and the sample stage in an exploded state according to an embodiment of the present invention.
  • the lift mechanism 60 may include a lift motor 61 , a drive screw 62 and a nut 63 .
  • the lift motor 61 is used to output driving force.
  • the driving screw 62 is arranged in the vertical direction and is connected with the output shaft of the lifting motor 61 to rotate under the driving of the lifting motor 61 .
  • the nut 63 is threaded on the drive screw 62 and is threadedly connected with the drive screw 62 to move up and down along the drive screw 62 with the rotation of the drive screw 62 .
  • the sample stage 70 is fixedly connected with the nut 63 , so that the nut 63 drives the sample stage 70 to move up and down.
  • the lifting mechanism 60 further includes a sliding rail 64 and a sliding block 65 .
  • the sliding rail 64 is arranged on the side of the driving screw 62 in parallel with the driving screw 62
  • the sliding block 65 is movably arranged on the sliding rail 64
  • the sample stage 70 is fixedly connected with the sliding block 65 to pass the sliding rail 64 and the sliding block 65.
  • the cooperation of the slider 65 guides the sample stage 70 to move up and down. Specifically, when the sample stage 70 moves in the up-down direction under the action of the drive module, it drives the slider 65 to move synchronously. Therefore, the sample stage 70 is indirectly guided and limited, thereby avoiding the deviation or jamming of the sample stage 70 during the moving process, and improving the stability of the movement of the sample stage 70 .
  • the sample stage 70 may include a horizontal connecting plate 74 that penetrates the drive screw 62 and is fixedly connected to the nut 63 and a vertical connecting plate 75 that extends upward perpendicular to the horizontal connecting plate 74.
  • the vertical connecting plate 75 is connected to the sliding Block 65 is fixedly connected.
  • the elevating mechanism 60 further includes a limit switch 66 , and the limit switch 66 is disposed adjacent to the upper part of the driving screw 62 to cause the elevating motor 61 to stop when the sample stage 70 moves upward until it touches the limit switch 66 . run. Also, the position of the limit switch 66 is set so that the sample stage 70 is in its detection position when the lift motor 61 stops running under the triggering of the limit switch 66 . The sample stage 70 can be held in its detection position when the lift motor 61 is not operating.
  • the limit switch 66 is used to locate the detection position of the sample stage 70, and the positioning is accurate, which can avoid the problem that the sample stage 70, the microfluidic biochip 10 and other structures are damaged due to the continuous movement of the sample stage 70 beyond its detection position.
  • the sample stage 70 may include a support stage 71 and an oscillator 72 .
  • the support table 71 is used to support the sample cup 2 .
  • the support table 71 may be a horizontally placed support plate, and a groove for placing the bottom of the sample cup 2 therein may be provided on the support plate, so as to prevent the sample cup 2 from tipping or falling during the movement of the sample table 70 . Shaking improves the stability of placing the sample cup 2 .
  • the support table 71 is fixedly connected to the horizontal connecting plate 74 .
  • the oscillator 72 is arranged on the support table 71, and is used to oscillate the sample cup 2 after placing the sample cup 2 on the support table 71, so that the buffer solution and the sample in the sample cup 2 are fully mixed, so that the sample to be detected on the sample is fully mixed. Substances are fully dissolved in the buffer to obtain the appropriate concentration of the sample solution.
  • the sample stage 70 further includes a load cell 73, and the load cell 73 is disposed under the support stage 71 to measure the weight of the sample in the sample cup 2, thereby allowing the buffer driving device 30 to interact with the A preset amount of buffer that matches the sample weight is delivered to sample cup 2.
  • the amount of buffer input in the sample cup 2 needs to be proportional to the amount of the sample. match, so that the sample solution of the appropriate concentration can be generated.
  • the weight of the sample can be obtained automatically and accurately through the load cell 73 placed under the support table 71, so as to automatically control the buffer driving device 30 to input a matching amount of buffer into the sample cup 2, which not only ensures the measurement result It also avoids many problems such as inconvenience, cumbersome operation, and large errors caused by users' manual weighing of samples, and further improves the automation degree of the microfluidic detection system and the user experience.
  • sample stage 70 may be fixed, and the microfluidic biochip 10 is set to be movable, which can also facilitate the sampling operation.
  • the microfluidic biochip 10 is removably above the sample stage 70 , and the injection port 111 is located at the bottom of the microfluidic biochip 10 .
  • the microfluidic detection system 1 further includes a chip mounting mechanism 51 and a chip ejecting mechanism 52 .
  • the chip mounting mechanism 51 is disposed in the housing 80 and is used to support the microfluidic biochip 10 .
  • the chip ejection mechanism 52 is used to operably release the support effect of the chip mounting mechanism 51 on the microfluidic biochip 10, so as to release the microfluidic biochip 10 so that it falls on the sample stage 70 under its own gravity.
  • the microfluidic biochip 10 can be automatically dropped into the sample cup 2 so as to be taken out and discarded together with the sample cup 2 .
  • the chip ejection mechanism 52 may be exposed on the front side of the housing 80, and then exposed on the front side of the door body 300, so as to facilitate the user to perform the chip ejection operation.
  • the microfluidic detection system 1 further includes a buffer bottle 36 and a buffer drive device 30 .
  • the buffer bottle 36 is disposed in the housing 80 and is used for containing the buffer.
  • the buffer solution driving device 30 is arranged in the housing 80 and communicates with the buffer solution bottle 36, so as to controllably drive the buffer solution in the buffer solution bottle 36 into the sample cup 2 placed on the sample stage 70, so that the buffer solution and the buffer solution can be driven into the sample cup 2 placed on the sample stage 70.
  • the sample in the sample cup 2 is mixed to produce a sample liquid.
  • the buffer bottle 36 is communicated with the buffer driving device 30 through the introduction pipe 32 .
  • the lead-out tube 31 of the buffer drive device 30 extends to the sample stage 70 .
  • the sample to be tested is a solid sample, and the substance to be detected on the solid sample needs to be dissolved in a buffer solution to form a sample liquid; or, the sample is a liquid sample, but the concentration is too high, and a buffer solution needs to be used.
  • the sample solution is produced after dilution.
  • the samples to be tested are usually solid food scraps such as epidermis and leaves.
  • the samples need to be placed in a buffer solution, and the residual pesticides on the samples are dissolved in the buffer solution to form a sample solution.
  • the buffer driving device 30 may be a peristaltic pump, a diaphragm pump or other suitable type of driving device.
  • the peristaltic pump or diaphragm pump may generate large vibration in its radial direction during operation.
  • the radial outer side of the peristaltic pump or diaphragm pump may be provided with an elastic vibration damping member 35 .
  • the elastic damping member 35 can be sleeved on the outside of the buffer driving device 30 , and supported in the housing 80 by the clamping action of the bracket 87 and the fixing block 89 , and the fixing block 89 can be fixed on the support plate 86 .
  • the microfluidic detection system 1 further includes a sample liquid driving device 40 , and the sample liquid driving device 40 is in sealing communication with the communication port 112 through the connecting pipeline 46 , so as to facilitate the inflow of the sample liquid in contact with the sample inlet 111 .
  • the microfluidic channel 14 flows to the detection cell 121 through the microfluidic channel 14 .
  • the communication port 112 , the detection cell 121 and the sample inlet 111 are connected in sequence to form a main channel, and the sample liquid driving device 40 can be urged to contact the sample inlet 111 by sucking air outward to form a negative pressure in the main channel
  • the sample liquid enters the microchannel and the detection cell 121 under the action of negative pressure.
  • sample liquid driving device 40 can be sealed and connected with the microfluidic biochip 10 through the sealing and docking mechanism 90 , so as to ensure that it is in sealing communication with the communication port 112 .
  • the sample liquid driving device 40 may be a micro syringe pump.
  • the microfluidic detection system 1 further includes a circuit board 53 , a display device 56 and a switch button 57 .
  • the circuit board 53 is disposed in the casing 80 and is electrically connected to the first electrical connector 82 on the casing 80 . connect.
  • the electrical components of the microfluidic detection system 1 are all directly or indirectly electrically connected to the circuit board 53 .
  • the display device 56 is disposed on the front side of the casing 80 and is electrically connected to the circuit board 53 for displaying the detection result of the detection mechanism 20 .
  • the switch button 57 is disposed on the front side of the housing 80 and is electrically connected to the circuit board 53 to enable and/or disable the detection function of the microfluidic detection system 1 . That is, the user can start, pause or stop the detection function of the microfluidic detection system 1 by operating the switch button 57 .
  • the housing 80 includes a rear shell 84 on the rear side and a front panel 85 attached to the front side of the rear shell 84 . After the rear case 84 and the front panel 85 are assembled, a cavity is defined between the two.
  • a support plate 86 and a bracket 87 are also provided in the accommodating cavity of the housing 80 .
  • the support plate 86 is fixedly connected with the rear case 84 , and at least part of the structure of the lift mechanism 60 (eg, the immovable part of the lift mechanism 60 ) and the buffer driving device 30 are fixed on the support plate 86 .
  • the bracket 87 is fixedly connected to the front side of the support plate 86 , and both the microfluidic biochip 10 and the sample liquid driving device 40 are directly or indirectly supported on the bracket 87 . Therefore, the lifting mechanism 60 , the buffer solution driving device 30 , the microfluidic biochip 10 and the sample liquid driving device 40 can be stably supported in the accommodation formed between the rear case 84 and the front panel 85 through the support plate 86 and the bracket 87 . intracavity.
  • the elevating mechanism 60 may be disposed on the lateral side of the sample stage 70
  • the buffer driving device 30 may be disposed on one side of the microfluidic biochip 10 in the lateral direction, above the elevating mechanism 60 .
  • the sample liquid driving device 40 is located on the other side of the microfluidic biochip 10 in the lateral direction
  • the buffer bottle 36 is located on the side of the sample liquid driving device 40 away from the microfluidic biochip 10 .
  • the microfluidic biochip 10 , the sample stage 70 , the lifting mechanism 60 , the buffer solution driving device 30 , the sample solution driving device 40 and the buffer solution bottle 36 after such a layout make full use of the vertical and horizontal dimensions of each module
  • the modules are only arranged side by side in the vertical direction and the lateral direction, which reduces the thickness of the microfluidic detection system 1 in the front and rear directions as much as possible, so that the microfluidic detection system 1 is integrated on the door body 300 Afterwards, the thickness of the door body 300 will not be increased, and the thickness of the thermal insulation layer of the door body 300 will not be greatly reduced.
  • a transversely extending baffle 861 may also be provided between the buffer driving device 30 and the lifting mechanism 60 to prevent the possible leakage of the buffer driving device 30 from falling on the lifting mechanism 60 and affecting the normal operation of the lifting mechanism 60 .
  • the partition plate 861 may be fixed on the support plate 86 .
  • the refrigerator 100 of the present application is a refrigerator in a broad sense, which includes not only a refrigerator in a narrow sense, but also a storage device having refrigeration, freezing or other storage functions, such as a refrigerator, a freezer, and the like.

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Abstract

一种冰箱，包括：箱体，其内限定有用于储存物品的储物空间；门体，与箱体相连，且用于打开和/或关闭储物空间；以及微流控检测系统，设置于门体上，且包括：微流控生物芯片，具有进样口和连通端口、以及形成在其内部的检测池，进样口、检测池、以及连通端口之间通过微流道依次连通，从而允许与进样口接触的样本液进入微流道并经微流道流入检测池；以及检测机构，用于在检测池内的样本液和其内的检测试剂反应后对检测池进行检测，以获取样本液的预设检测参数。由此，不但用户操作起来比较方便，而且还不会占用箱体内原有的储物空间，不会对冰箱本身的储物能力产生影响。

Description

冰箱 技术领域
本发明涉及冷藏冷冻技术，特别是涉及一种冰箱。
背景技术
随着人们生活水平的提高，日常生活中通常需要对食用的一些食材的农残、病毒、营养元素或其他方面进行检测，以定性或定量地获取食材的状况。例如，由于农药滥用问题，我们日常买到的果蔬和农副产品有可能出现农残含量超标的问题，如果不能及时发现这些食品的农残含量超标问题，人体摄入后会造成极大危害。再如，目前提倡的母乳喂养，只有在母乳具有正常营养价值的情况下才是对婴儿最好的喂养，然而在乳母生病、吃药、手术或其他情况下可能导致其分泌的乳汁中的营养元素含量降低甚至产生病毒，从而影响婴儿的生长发育和健康。
然而，现有的检测系统一般是独立存在的，占用空间、不便于收纳，将检测装置收纳起来后又会忘记使用，或者嫌麻烦不拿出来使用。为此，现有技术中存在将用于农残检测的检测系统集成在冰箱冷藏室或在冰箱储物空间中额外设置一个农残检测室，无论是哪种方案都会占用较多的储物空间，影响用户的使用体验。
发明内容
本发明的一个目的旨在克服现有技术的至少一个缺陷，提供一种具有微流控检测系统、且微流控检测系统不占用原有储物空间的冰箱。
本发明的一个进一步的目的是保持冰箱良好的保温性能、提高用户使用微流控检测系统的操作便利性。
本发明的另一个进一步的目的是便于微流控检测系统的装配和拆卸。
为了实现上述目的，本发明提供一种冰箱，包括：
箱体，其内限定有用于储存物品的储物空间；
门体，与所述箱体相连，且用于打开和/或关闭所述储物空间；以及
微流控检测系统，设置于所述门体上，且包括：
微流控生物芯片，具有进样口、连通端口、以及形成在其内部的检测池，所述进样口、所述检测池、以及所述连通端口之间通过微流道依次连通，从 而允许与所述进样口接触的样本液进入所述微流道并经所述微流道流入所述检测池；以及
检测机构，用于对所述检测池进行检测，以获取所述样本液的预设检测参数。
可选地，所述微流控检测系统还包括：
样品台，用于放置样本杯，所述样本杯用于盛放样本液；以及
壳体，其上形成有朝向其前侧敞开的操作台，所述样品台至少部分地位于所述操作台中。
可选地，所述门体的前侧开设有镂空窗口，所述操作台经所述镂空窗口暴露于所述门体的前侧。
可选地，所述门体包括用于形成其前部的面板、用于形成其后部的门衬以及设置在所述面板和所述门衬之间的发泡保温层，所述镂空窗口开设在所述面板上；且
所述面板和所述门衬之间在形成所述发泡保温层之前预埋有一预埋盒，所述微流控检测系统设置在所述预埋盒内。
可选地，所述预埋盒贴设于所述面板的后向表面，且所述预埋盒的前侧敞开，并正对所述镂空窗口，以允许所述微流控检测系统经所述镂空窗口从前往后地安装至所述预埋盒内。
可选地，所述壳体上设有用于与所述预埋盒相连的第一结构连接件、以及用于在所述微流控检测系统和所述冰箱的电控装置之间形成电连接的第一电连接件，以允许所述微流控检测系统作为一个整体安装至所述门体；
所述预埋盒上设有与所述第一结构连接件匹配连接的第二结构连接件和与所述第一电连接件电连接的第二电连接件，所述第二电连接件与所述电控装置电连接。
可选地，所述微流控生物芯片设置在所述样品台的上方，所述进样口位于所述微流控生物芯片的底部；且
所述样品台设置成受控地或可操作地上下移动，以使得所述样品台在允许置于所述样品台上的样本杯中的样本液与所述进样口接触的检测位置和处于所述检测位置下方预设距离的初始位置之间切换。
可选地，所述微流控生物芯片可移除地处于所述样品台的上方，所述进样口位于所述微流控生物芯片的底部；且
所述微流控检测系统还包括：
芯片安装机构，设置于所述壳体内，且用于支撑所述微流控生物芯片；
芯片退出机构，用于可操作地解除所述芯片安装机构对所述微流控生物芯片的支撑作用，以释放所述微流控生物芯片，使其在自身重力作用下掉落在所述样品台上。
可选地，所述微流控检测系统还包括：
缓冲液瓶，设置于所述壳体内，且用于容装缓冲液；以及
缓冲液驱动装置，设置于所述壳体内，且与所述缓冲液瓶连通，以受控地驱动所述缓冲液瓶内的缓冲液进入放置在所述样品台上的样本杯，从而使所述缓冲液与所述样本杯中的样本混合后产生样本液。
可选地，所述样品台包括：
支撑台，用于支撑样本杯；以及
振荡器，设置于所述支撑台上，用于在所述支撑台上放置所述样本杯后对所述样本杯进行振荡，以使得所述样本杯中的缓冲液和样本充分混合。
可选地，所述微流控检测系统还包括：
样本液驱动装置，与所述连通端口密封地连通，以促使与所述进样口接触的样本液流入所述微流道并经所述微流道流向所述检测池。
本发明的冰箱设有微流控检测系统，省去了微流控检测系统的独立收纳，不占用室内空间。并且，冰箱是很常用的家用电器，便于用户随机地利用冰箱上的微流控检测系统进行农残检测、营养元素检测或母乳检测等检测需求，使用方便、快捷。同时，微流控检测系统设置在门体上，不但操作起来比较方便，而且还不会占用箱体内原有的储物空间，不会对冰箱本身的储物能力产生影响。
进一步地，微流控检测系统的壳体上形成有朝前敞开的操作台，样品台位于操作台中，门体的前侧设有镂空窗口，操作台经门体的镂空窗口暴露于门体的前侧。也就是说，操作台是外露式的，便于用户在不必打开门体的情况下在操作台中进行一系列的操作，例如取放样本杯、更换微流控生物芯片等，一方面，可避免因设置微流控检测系统导致门体打开频率增加而漏冷严重的问题，确保了冰箱具有良好的保温性能；另一方面，用户执行检测操作时不必打开门体，提高了用户使用微流控检测系统的操作便利性。
进一步地，门体上设有预埋盒，微流控检测系统具有壳体，通过在预埋 盒和壳体上设置相应的结构连接件和电连接件使得微流控检测系统作为一个整体安装至门体上，从而在结构和电路两个方面实现整个微流控检测系统与冰箱之间的连接。由此，不但简化了微流控检测系统的装配过程，而且便于微流控检测系统的拆卸或维修。
根据下文结合附图对本发明具体实施例的详细描述，本领域技术人员将会更加明了本发明的上述以及其他目的、优点和特征。
附图说明
后文将参照附图以示例性而非限制性的方式详细描述本发明的一些具体实施例。附图中相同的附图标记标示了相同或类似的部件或部分。本领域技术人员应该理解，这些附图未必是按比例绘制的。附图中：
图1是根据本发明一个实施例的冰箱的示意性结构图；
图2是根据本发明一个实施例的微流控检测系统的示意性结构图；
图3是根据本发明一个实施例的微流控检测系统的示意性结构分解图；
图4是根据本发明一个实施例的微流控检测系统内部结构的示意性结构图；
图5是根据本发明一个实施例的微流控检测系统内部结构的示意性结构分解图；
图6是根据本发明一个实施例的微流控生物芯片的示意性剖视图；
图7是根据本发明一个实施例的门体的示意性结构分解图；
图8是根据本发明一个实施例的升降机构和样品台处于分解状态的示意性结构图。
具体实施方式
本发明提供一种冰箱。图1是根据本发明一个实施例的冰箱的示意性结构图。参见图1，本发明涉及的冰箱100包括箱体200和门体300。箱体200内限定有用于储存物品的储物空间，门体300与箱体200相连，且用于打开和/或关闭其储物空间。
特别地，冰箱100还包括微流控检测系统1，微流控检测系统1设置在门体300上。微流控检测系统1用于对样本液的预设检测参数进行定性或定量检测，该预设检测参数例如可以为用于表示农残量是否超标和/或农残量的具体数值的农残参数、用于表示营养元素是否达标和/或营养元素具体含量的 营养参数、用于表示特定有害物质(例如特定病毒)是否超标和/或具体含量的特定物质参数等等。
图2是根据本发明一个实施例的微流控检测系统的示意性结构图，图3是根据本发明一个实施例的微流控检测系统的示意性结构分解图，图4是根据本发明一个实施例的微流控检测系统内部结构的示意性结构图，图5是根据本发明一个实施例的微流控检测系统内部结构的示意性结构分解图。为了便于理解，图1至图5中还示出了样本杯2。
参见图2至图5，微流控检测系统1可包括微流控生物芯片10和检测机构20。本领域技术人员可以理解的是，当微流控检测系统用于检测的预设检测参数不同时，其所使用的微流控生物芯片10和检测机构20的具体选择可能也有所不同。例如，当微流控检测系统用于农残检测时，其具有的微流控生物芯片10可以是能够为农残液提供检测条件的微流控农残检测芯片，其具有的检测机构20可以是能够对农残液的农残参数进行检测的农残检测机构。
图6是根据本发明一个实施例的微流控生物芯片的示意性剖视图，微流控生物芯片10具有形成在其端部的进样口111、连通端口112、以及形成在其内部的检测池121，进样口111、检测池121、以及连通端口112之间通过微流道14依次连通，从而允许与进样口111接触的样本液流入微流道14并经微流道14流入检测池121。本发明所涉及的微流道14意指过流面积在预设尺寸范围内的细微流道或毛细流道，以使其具有合适的保持其内液体的能力。进样口111和连通端口112可形成在微流控生物芯片10的端部。进一步地，进样口111和连通端口112优选形成在微流控生物芯片10的不同端部。
检测机构20用于对检测池121进行检测，以获取样本液的预设检测参数。具体地，检测池121内可预先设有检测试剂，也可通过人为地或自动地向检测池121内添加检测试剂，以在检测池121内的样本液和其内的检测试剂反应后通过检测机构20对检测池121进行检测。
本发明的冰箱100设有微流控检测系统1，省去了微流控检测系统1的独立收纳，不占用室内空间。并且，冰箱100是很常用的家用电器，便于用户随机地利用冰箱100上的微流控检测系统1进行农残检测、营养元素检测或母乳检测等检测需求，使用方便、快捷。同时，微流控检测系统1设置在 门体300上，不但操作起来比较方便，而且还不会占用箱体200内原有的储物空间，不会对冰箱100本身的储物能力产生影响。
在一个具体的实施例中，当检测机构20为用于对农残液的农残参数进行检测的农残检测机构时，可使用酶抑制率法对样本液的农残是否超标进行快速的定性检测。此时，微流控生物芯片10还包括形成在其内部的反应池122，反应池122位于进样口111、检测池121、以及连通端口112依次连通形成的主通道上，并连通在进样口111和检测池121之间，以使得样本液先与反应池122内的反应试剂反应后再流入检测池121。反应池122与进样口111之间、以及反应池122与检测池121之间均通过微通道14连通。用于农残检测的反应试剂和检测试剂可以分别为酶试剂和显色剂。反应池122用于供样本液和其内的酶试剂反应，与酶试剂反应后的样本液流入检测池121，与检测池121内的显色剂进行反应。检测机构20可以选择为光电检测机构，其可以包括分别设置在微流控生物芯片10的两个相对的侧部并均与检测池121正对的光源21和光敏元件22，光源21发出的光照射至检测池121，透过检测池121的光导入光敏元件22，从而利于通过光敏元件22接收到的光强信号判断检测池121内的吸光度变化，进而计算农残抑制率。进一步地，检测机构20还包括用于向检测池121提供热量的加热片24和用于控制加热片24加热功率恒定的温控器25，以使得检测池121内的样本液和检测试剂充分、快速地反应。
在一些实施例中，微流控检测系统1还包括样品台70和壳体80。样品台70用于放置样本杯2，样本杯2用于盛放样本液。壳体80上形成有朝向其前侧敞开的操作台83，样品台70至少部分地位于操作台83中，从而便于用户在操作台83中实施放置样本杯2、取出样本杯2等操作。操作台83中可设有处于样品台70下方的接水盒88，以承接可能滴落的液体，避免污染操作台83。微流控生物芯片10的至少部分区段和检测机构20均设置在壳体80内。
图7是根据本发明一个实施例的门体的示意性结构分解图。进一步地，参见图1、图2和图7，门体300的前侧开设有镂空窗口301，操作台83经镂空窗口301暴露于门体300的前侧。也就是说，操作台83是外露式的，便于用户在不必打开门体300的情况下在操作台83中进行一系列的操作，例如取放样本杯2、更换微流控生物芯片10等，一方面，可避免冰箱100 因设置微流控检测系统1导致门体300打开频率增加而漏冷严重的问题，确保了冰箱100具有良好的保温性能；另一方面，用户执行检测操作时不必打开门体300，提高了用户使用微流控检测系统1的操作便利性。
在一些实施例中，门体300包括用于形成其前部的面板302、用于形成其后部的门衬303以及设置在面板302和门衬303之间的发泡保温层(图中未示出)，镂空窗口301开设在面板302上。面板302和门衬303之间在形成发泡保温层之前预埋有一预埋盒304，微流控检测系统1设置在预埋盒304内。也就是说，预埋盒304是在门体300发泡之前预先设置在面板302和门衬303之间的，用于在面板302和门衬303之间预留出用于安装微流控检测系统1的空间。
进一步地，预埋盒304贴设于面板302的后向表面，且预埋盒304的前侧敞开，并正对镂空窗口301，以允许微流控检测系统1经镂空窗口301从前往后地安装至预埋盒304内，提高了微流控检测系统1安装的便利性。
在一些实施例中，壳体80上设有用于与预埋盒304相连的第一结构连接件81、以及用于在微流控检测系统1和冰箱100的电控装置之间形成电连接的第一电连接件82，以允许微流控检测系统1作为一个整体安装至门体300。预埋盒304上设有与第一结构连接件81匹配连接的第二结构连接件305和与第一电连接件82电连接的第二电连接件306，第二电连接件306与冰箱100的电控装置电连接。由此，通过在预埋盒304和壳体80上设置相应的结构连接件和电连接件使得微流控检测系统1作为一个整体安装至门体300上，从而在结构和电路两个方面实现整个微流控检测系统1与冰箱100之间的连接。由此，不但简化了微流控检测系统1的装配过程，而且便于微流控检测系统1的拆卸或维修。
在一些实施例中，微流控生物芯片10设置在样品台70的上方，进样口111位于微流控生物芯片10的底部。样品台70设置成受控地或可操作地上下移动，以使得样品台70在允许置于其上的样本杯2中的样本液与进样口111相接触的检测位置和处于检测位置下方预设距离的初始位置之间切换。由此，实现了微流控生物芯片10的加样。用户只需要将样本杯2放置在样品台70上，或者，在将样本杯2放置在样品台70后再将样品台70移动至与微流控生物芯片10的进样口111相接触的位置即可，加样操作非常便捷，省时省力。并且，本申请通过将样品台70设置成可动的，省去了样本液输 送泵、输送管路、采样针等复杂的结构，使得微流控检测系统1的结构非常简单，从而使其适用于集成在冰箱上，便于家庭使用。同时，初始位置处于检测位置下方的预设距离，在放置样本杯2时不会与微流控生物芯片10或其他结构产生干涉，进一步提高了操作的便捷性和舒适度。
进一步地，微流控检测系统1还包括用于驱动样品台70上下移动的升降机构60，以使得样品台70在检测位置和初始位置之间自动切换。也就是说，样品台70可以通过升级机构60自动升降。在加样时，用户只需要在样品台70处于初始位置时将样本杯2放置在样品台70上即可，升降机构60可自动地将样品台70抬升至其检测位置，不需要用户继续参与，提高了微流控检测系统1的自动化程度。并且，初始位置处于检测位置下方的预设距离，在放置样本杯2时不会与微流控生物芯片10或其他结构产生干涉，进一步提高了操作的便捷性和舒适度。
图8是根据本发明一个实施例的升降机构和样品台处于分解状态的示意性结构图。在一些实施例中，升降机构60可包括升降电机61、传动丝杆62和螺母63。升降电机61用于输出驱动力。传动丝杆62沿竖直方向设置，且与升降电机61的输出轴相连，以在升降电机61的驱动下转动。螺母63穿设在传动丝杆62上，并与传动丝杆62螺纹连接，以随传动丝杆62的转动沿传动丝杆62上下移动。样品台70与螺母63固定连接，以通过螺母63带动样品台70上下移动。
进一步地，升降机构60还包括滑轨64和滑块65。滑轨64与传动丝杆62相平行地设置在传动丝杆62的旁侧，滑块65可移动地设置在滑轨64上，样品台70与滑块65固定连接，以通过滑轨64和滑块65的配合引导样品台70上下移动。具体地，样品台70在驱动模块的作用下沿上下方向移动时带动滑块65同步移动，滑块65被限制在滑轨64上，滑轨64对滑块65的移动具有引导和限位的作用，从而间接地对样品台70产生引导和限位作用，避免了样品台70在移动过程中产生偏移或卡顿，提高了样品台70运动的平稳性。具体地，样品台70可包括穿设在传动丝杆62中并与螺母63固定相连的水平连接板74以及垂直于水平连接板74向上延伸的竖直连接板75，竖直连接板75与滑块65固定连接。
在一些实施例中，升降机构60还包括限位开关66，限位开关66邻近传动丝杆62的上部设置，以在样品台70向上移动至触碰到限位开关66时促 使升降电机61停止运行。并且，限位开关66的位置设置成当升降电机61在限位开关66的触发下停止运行时使得样品台70处于其检测位置。升降电机61不运行时可使样品台70保持在其检测位置。本申请通过限位开关66来定位样品台70的检测位置，定位精准，可避免样品台70超出其检测位置继续移动导致样品台70、微流控生物芯片10等结构损坏的问题。
在一些实施例中，样品台70可包括支撑台71和振荡器72。支撑台71用于支撑样本杯2。具体地，支撑台71可以为水平放置的支撑板，支撑板上可设置用于供样本杯2的底部放置于其内的凹槽，以在样品台70的移动过程中避免样本杯2倾倒或晃动，提高了样本杯2放置的稳固性。支撑台71与水平连接板74固定连接。
振荡器72设置于支撑台71上，用于在支撑台71上放置样本杯2后对样本杯2进行振荡，以使得样本杯2中的缓冲液和样本充分混合，从而使得样本上的待检测物质充分地溶解到缓冲液中得到合适浓度的样本液。
在一些实施例中，样品台70还包括称重传感器73，称重传感器73设置于支撑台71的下方，以用于测称样本杯2中样本的重量，从而允许缓冲液驱动装置30将与样本重量相匹配的预设量的缓冲液输送至样本杯2。通常情况下，家庭用户对样本的提取是比较随意的，比如随意撕下一小片菜叶，因此，为了保证测量结果的准确性，输入样本杯2中的缓冲液的量需要与样本的量相匹配，这样才能够产生合适浓度的样本液。本申请通过置于支撑台71下方的称重传感器73可自动地、精确地获得样本的重量，从而自动控制缓冲液驱动装置30向样本杯2中输入匹配量的缓冲液，既保证了测量结果的准确性，又避免了用户手动测称样本导致使用不便、操作繁琐、误差较大等诸多问题，进一步提高了微流控检测系统的自动化程度和用户的使用体验。
需要说明的是，在一些替代性实施例中，样品台70可以为固定的，微流控生物芯片10设置成可动的，同样能够便于取样操作。
在一些实施例中，微流控生物芯片10可移除地处于样品台70的上方，进样口111位于微流控生物芯片10的底部。并且，微流控检测系统1还包括芯片安装机构51和芯片退出机构52。芯片安装机构51设置于壳体80内，且用于支撑微流控生物芯片10。芯片退出机构52用于可操作地解除芯片安装机构51对微流控生物芯片10的支撑作用，以释放微流控生物芯片10，使其在自身重力作用下掉落在样品台70上。当样品台70上放置样本杯2时， 微流控生物芯片10可自动掉落在样本杯2中，以便于随样本杯2一起被取出丢弃。优选地，芯片退出机构52可裸露于壳体80的前侧，进而裸露于门体300的前侧，从而便于用户实施芯片退出操作。
在一些实施例中，微流控检测系统1还包括缓冲液瓶36和缓冲液驱动装置30。缓冲液瓶36设置于壳体80内，且用于容装缓冲液。缓冲液驱动装置30设置于壳体80内，且与缓冲液瓶36连通，以受控地驱动缓冲液瓶36内的缓冲液进入放置在样品台70上的样本杯2，从而使缓冲液与样本杯2中的样本混合后产生样本液。具体地，缓冲液瓶36与缓冲液驱动装置30之间通过引入管32连通。缓冲液驱动装置30的引出管31延伸至样品台70。这主要是针对被检测的样本为固态样本，需要利用缓冲液将固态样本上的待检测物质溶解到其中从而形成样本液；或者，样本为液态样本，但是浓度过高，需要利用缓冲液对其进行稀释后产生样本液。例如，在进行农残检测时，被检测的样本通常为表皮、叶片等固体的食材残片，需要将样本置于缓冲液中，样本上的残留农药溶解到缓冲液中，从而形成样本液。
具体地，缓冲液驱动装置30可以为蠕动泵、隔膜泵或其他合适类型的驱动装置。蠕动泵或隔膜泵在运行时会在其径向上产生较大的振动，为了避免该振动传递至微流控生物芯片10，蠕动泵或隔膜泵的径向外侧可设有弹性减振件35。弹性减振件35可套设在缓冲液驱动装置30的外部，并通过支架87和固定块89的夹持作用支撑在壳体80内，固定块89可固定在支撑板86上。
在一些实施例中，微流控检测系统1还包括样本液驱动装置40，样本液驱动装置40通过连接管路46与连通端口112密封地连通，以促使与进样口111接触的样本液流入微流道14并经微流道14流向检测池121。具体地，连通端口112、检测池121和进样口111依次连通形成主通道，样本液驱动装置40可通过向外抽吸空气以在主通道内形成负压的方式促使与进样口111接触的样本液在负压作用下进入微通道和检测池121。进一步地，样本液驱动装置40可通过密封对接机构90与微流控生物芯片10密封对接，从而确保其与连通端口112密封地连通。具体地，样本液驱动装置40可以为微型注射泵。
在一些实施例中，微流控检测系统1还包括电路板53、显示装置56和开关按键57，电路板53设置于壳体80内，且与壳体80上的第一电连接件 82电连接。微流控检测系统1的用电部件均直接或间接地与电路板53电连接。显示装置56设置在壳体80的前侧，且与电路板53电连接，以用于显示检测机构20的检测结果。开关按键57设置在壳体80的前侧，且与电路板53电连接，以用于启动和/或关闭微流控检测系统1的检测功能。也就是说，用户可通过操作开关按键57启动、暂停或停止微流控检测系统1的检测功能。
在一些实施例中，壳体80包括处于后侧的后壳84和连接在后壳84前侧的前面板85。后壳84与前面板85组装后在二者之间限定处容纳腔。并且，壳体80的容纳腔内还设有支撑板86和支架87。支撑板86与后壳84固定连接，升降机构60的至少部分结构(例如升降机构60的不可动部分)和缓冲液驱动装置30均固定在支撑板86上。支架87固定连接在支撑板86的前侧，微流控生物芯片10和样本液驱动装置40均直接或间接地支撑在支架87上。由此，可通过支撑板86与支架87将升降机构60、缓冲液驱动装置30、微流控生物芯片10和样本液驱动装置40稳固地支撑在后壳84与前面板85之间形成的容纳腔内。
在一些实施例中，升降机构60可设置在样品台70在横向上的旁侧，缓冲液驱动装置30可设置在微流控生物芯片10在横向上的一侧，并位于升降机构60的上方，样本液驱动装置40位于微流控生物芯片10在横向上的另一侧，缓冲液瓶36位于样本液驱动装置40的背离微流控生物芯片10的一侧。这样布局后的微流控生物芯片10、样品台70、升降机构60、缓冲液驱动装置30、样本液驱动装置40和缓冲液瓶36充分地利用了各个模块在竖直方向和横向上的尺寸特征，使得各个模块的布局更加紧凑，尽可能地减小占用空间。并且，各个模块之间仅在竖直方向上和横向上并排设置，尽可能地缩小了微流控检测系统1在前后方向上的厚度，从而在微流控检测系统1集成在门体300上后不会增加门体300的厚度，也不会较多地减小门体300保温层的厚度。
缓冲液驱动装置30和升降机构60之间还可设有横向延伸的隔板861，以避免缓冲液驱动装置30可能产生的漏液滴落在升降机构60上对升降机构60的正常运行产生影响。隔板861可固定在支撑板86上。
本申请的冰箱100为广义上的冰箱，其不但包括通常所说的狭义上的冰箱，而且还包括具有冷藏、冷冻或其他储物功能的储物装置，例如，冷藏箱、 冷柜等等。
本领域技术人员还应理解，本发明实施例中所称的“上”、“下”、“前”、“后”、“顶”、“底”等用于表示方位或位置关系的用语是以冰箱100的实际使用状态为基准而言的，这些用语仅是为了便于描述和理解本发明的技术方案，而不是指示或暗示所指的装置或不见必须具有特定的方位、以特定的方位构造和操作，因此不能理解为对本发明的限制。
至此，本领域技术人员应认识到，虽然本文已详尽示出和描述了本发明的多个示例性实施例，但是，在不脱离本发明精神和范围的情况下，仍可根据本发明公开的内容直接确定或推导出符合本发明原理的许多其他变型或修改。因此，本发明的范围应被理解和认定为覆盖了所有这些其他变型或修改。

Claims (11)

  1. 一种冰箱，包括：
    箱体，其内限定有用于储存物品的储物空间；
    门体，与所述箱体相连，且用于打开和/或关闭所述储物空间；以及
    微流控检测系统，设置于所述门体上，且包括：
    微流控生物芯片，具有进样口、连通端口、以及形成在其内部的检测池，所述进样口、所述检测池、以及所述连通端口之间通过微流道依次连通，从而允许与所述进样口接触的样本液进入所述微流道并经所述微流道流入所述检测池；以及
    检测机构，用于对所述检测池进行检测，以获取所述样本液的预设检测参数。
  2. 根据权利要求1所述的冰箱，其中，所述微流控检测系统还包括：
    样品台，用于放置样本杯，所述样本杯用于盛放样本液；以及
    壳体，其上形成有朝向其前侧敞开的操作台，所述样品台至少部分地位于所述操作台中。
  3. 根据权利要求2所述的冰箱，其中，
    所述门体的前侧开设有镂空窗口，所述操作台经所述镂空窗口暴露于所述门体的前侧。
  4. 根据权利要求3所述的冰箱，其中，
    所述门体包括用于形成其前部的面板、用于形成其后部的门衬以及设置在所述面板和所述门衬之间的发泡保温层，所述镂空窗口开设在所述面板上；且
    所述面板和所述门衬之间在形成所述发泡保温层之前预埋有一预埋盒，所述微流控检测系统设置在所述预埋盒内。
  5. 根据权利要求4所述的冰箱，其中，
    所述预埋盒贴设于所述面板的后向表面，且所述预埋盒的前侧敞开，并正对所述镂空窗口，以允许所述微流控检测系统经所述镂空窗口从前往后地 安装至所述预埋盒内。
  6. 根据权利要求5所述的冰箱，其中，
    所述壳体上设有用于与所述预埋盒相连的第一结构连接件、以及用于在所述微流控检测系统和所述冰箱的电控装置之间形成电连接的第一电连接件，以允许所述微流控检测系统作为一个整体安装至所述门体；
    所述预埋盒上设有与所述第一结构连接件匹配连接的第二结构连接件和与所述第一电连接件电连接的第二电连接件，所述第二电连接件与所述电控装置电连接。
  7. 根据权利要求2所述的冰箱，其中，
    所述微流控生物芯片设置在所述样品台的上方，所述进样口位于所述微流控生物芯片的底部；且
    所述样品台设置成受控地或可操作地上下移动，以使得所述样品台在允许置于所述样品台上的样本杯中的样本液与所述进样口接触的检测位置和处于所述检测位置下方预设距离的初始位置之间切换。
  8. 根据权利要求2所述的冰箱，其中，
    所述微流控生物芯片可移除地处于所述样品台的上方，所述进样口位于所述微流控生物芯片的底部；且
    所述微流控检测系统还包括：
    芯片安装机构，设置于所述壳体内，且用于支撑所述微流控生物芯片；
    芯片退出机构，用于可操作地解除所述芯片安装机构对所述微流控生物芯片的支撑作用，以释放所述微流控生物芯片，使其在自身重力作用下掉落在所述样品台上。
  9. 根据权利要求2所述的冰箱，其中，所述微流控检测系统还包括：
    缓冲液瓶，设置于所述壳体内，且用于容装缓冲液；以及
    缓冲液驱动装置，设置于所述壳体内，且与所述缓冲液瓶连通，以受控地驱动所述缓冲液瓶内的缓冲液进入放置在所述样品台上的样本杯，从而使所述缓冲液与所述样本杯中的样本混合后产生样本液。
  10. 根据权利要求9所述的冰箱，其中，所述样品台包括：
    支撑台，用于支撑样本杯；以及
    振荡器，设置于所述支撑台上，用于在所述支撑台上放置所述样本杯后对所述样本杯进行振荡，以使得所述样本杯中的缓冲液和样本充分混合。
  11. 根据权利要求1所述的冰箱，其中，所述微流控检测系统还包括：
    样本液驱动装置，与所述连通端口密封地连通，以促使与所述进样口接触的样本液流入所述微流道并经所述微流道流向所述检测池。
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