WO2022058633A1 - Système de contrôle de diagnostic avec dispositif automatique d'extraction, d'assainissement et d'analyse d'échantillon biologique - Google Patents

Système de contrôle de diagnostic avec dispositif automatique d'extraction, d'assainissement et d'analyse d'échantillon biologique Download PDF

Info

Publication number
WO2022058633A1
WO2022058633A1 PCT/ES2021/070465 ES2021070465W WO2022058633A1 WO 2022058633 A1 WO2022058633 A1 WO 2022058633A1 ES 2021070465 W ES2021070465 W ES 2021070465W WO 2022058633 A1 WO2022058633 A1 WO 2022058633A1
Authority
WO
WIPO (PCT)
Prior art keywords
analysis unit
extraction
opening
blood samples
extraction device
Prior art date
Application number
PCT/ES2021/070465
Other languages
English (en)
Spanish (es)
Inventor
Chito Oliveras MIGUEL
Original Assignee
Miguel Chito Oliveras
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Miguel Chito Oliveras filed Critical Miguel Chito Oliveras
Publication of WO2022058633A1 publication Critical patent/WO2022058633A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M1/00—Apparatus for enzymology or microbiology
    • C12M1/34—Measuring or testing with condition measuring or sensing means, e.g. colony counters
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation

Definitions

  • the present invention corresponds to the technical field of health, and specifically to a sanitary device and a device for managing it, which allows the automatic extraction of blood samples plus sanitation and obtaining a rapid diagnosis of the presence of viruses. or certain diseases.
  • waiting times for the results of the order of four days are handled under normal conditions, which in certain circumstances is inoperative and does not allow the security that is needed prior to certain situations, such as a trip, an event, to be provided.
  • hospital centers and laboratories tend to have a greater workload, even being overwhelmed, so waiting times for an analytical result increase considerably.
  • the strategy for detecting the genetic material of the virus is the one used by the PCR (Polymerase Chain Reaction) technique. It is used routinely in all clinical laboratories and is based on the amplification of DNA fragments through consecutive cycles of increases and decreases in temperature, which allows, from few initial DNA sequences (few copies of generic material) expand to large amounts that can be detected by fluorescence.
  • PCR Polymerase Chain Reaction
  • the detection is not of the generic material but of the entire virus from the detection of the so-called viral antigens.
  • One way to detect it is to use the so-called Rapid Antigen Detection Tests. This approach is simple, although highly dependent on the availability of specific antibodies whose quality will depend on greater specificity and sensitivity of the analysis.
  • serological tests for the detection of antibodies generated in the host organism are based on the indirect detection of the virus, through the specific measurement of the antibodies generated by the infected person's own organism produced by their immune system. These serological tests can provide valuable information regarding an active infection or previous contagion. It is a fairly fast option, but again it has limited sensitivity, with a high possibility of false negatives, reproducibility problems that can lead to false positives and/or negatives, and an essentially qualitative response.
  • the immune system requires time to activate and generate antibodies and there is an inherent variability in the immune response of each individual, so the results may vary depending on these factors.
  • WO1998031275 As an example of the state of the art, reference document WO1998031275 can be mentioned, in which an apparatus and system for telematic control of physiological parameters of patients is defined.
  • the device is portable and small in size. It has a blood glucose analyzer that obtains a series of values that can be processed in situ by a microprocessor and displayed on a screen of a personal computer coupled to the glucose analyzer.
  • the system consists in that the medical data in the portable device can be transmitted to a central remote interpretation unit through a mobile phone interconnected with the microprocessor and the analyzer.
  • the device requires a storage memory for the collected data, an auto-analyzer and an operating program for communication with the system.
  • This device and system although valid for the purpose of measuring glucose, is inoperative for the objective pursued in this case, which is to achieve a device with which it is possible to measure safely and reliably any person in any time information about their health status is required, freeing the user from the need to acquire and carry a device for this purpose at all times.
  • each of these devices requires a series of internal elements that make them more complicated and more expensive, such as a memory capable of storing patient data, the autoanalyzer... and this for each of the devices.
  • the central unit must be able to store the data of all the patients in order to be able to communicate with the device and issue a diagnosis to the doctor. This complicates the necessary elements, and requires a communication network that is not always possible or exists in all places.
  • the sealed analysis unit for a blood sample for its evaluation by means of a diagnostic device presented here, comprises a first fixed portion that has a sample extraction device and a first opening for access to it from the exterior, as well as a second portion coupled to the previous one in a hermetically sealed and encapsulated way, such that a germ-free hygienic union results.
  • Said second portion presents a longitudinally shaped cleaning device fitted therein, such that it is arranged between the extraction device and the first opening, and comprising a second opening.
  • the second portion also comprises means for sanitizing a puncture area on the user's finger, located on both sides of the second opening and means for moving with respect to the first portion, following a direction from one end to the opposite end of the opening. first opening, such that in a coincident position of the first and second openings, it allows access to the extraction device.
  • the device for extracting the first portion comprises a sample receiving tank arranged in a housing in the upper part thereof, in correspondence with the first access opening to the outside of the first portion and connected to a card integrated circuit SIM arranged at one end of said extraction device.
  • It also has a first vertical through hole arranged through the extraction device and the receiving tank, and a mechanism for executing a puncture in the user's finger by means of a hypodermic needle arranged in the first through hole.
  • This specification also proposes an apparatus for extracting blood samples, by means of an analysis unit as previously defined, comprising an external casing with an extraction zone with a third opening for access to the interior of the apparatus.
  • This casing comprises inside at least a plurality of sealed analysis units, a diagnostic device with means of connection to the SIM of the analysis unit that is located in the extraction area of the device, a microprocessor with control software connected to the diagnostic device, to the means for moving the analysis units and to the means for moving the second portion with respect to the first, and an internal memory connected to the control software (28).
  • This unit is sealed, so it is safe and it is also individual and single-use, thus ensuring factory sterilization, not being necessary to carry out intermediate sterilization tasks after each use.
  • At least one triple analysis reactive strip is used, so that with a single test you can obtain three results: qualitative, which provides information on whether a substance is found in a sample or not; quantitative, which provide information about the concentration of a substance in a sample; and semiquantitative, which offers a quantification of a compound in a non-numerical way, for example: positive (++), possible positive (+), possible negative (-), negative (-).
  • the device's software performs a triangulation of the results obtained, granting us a more complete and conclusive diagnosis of the user's state of health.
  • you can incorporate more than one test strip in each analysis unit it is possible to obtain one or more pathological diagnoses from a single analytical extraction.
  • the extraction apparatus by said unit can have two versions.
  • the first of these is a device that can be moved to the risk area where its use is required, to be installed continuously in that place.
  • This version consists of a casing inside which it has storage means for a large number of analysis units and means for supplying a unit to the extraction area when a user requires it. Therefore, in this version of the extraction apparatus, the supply of analysis units is spaced out over time, since it has a large number of units with which to carry out the extraction to a large number of users.
  • the second device option is a mobile device, for manual use, in which there is space for a single analysis unit and once used it is discarded and a new unit is replaced in its place, in order to scan a new user.
  • a great advantage of this extraction device is that the integrated software allows an efficient development of the process, not only of the execution of the analysis itself, but also with the communication with the user. In this way, the user connects with the device through the computer application installed on a mobile device, and configured for this purpose.
  • This application contains all the necessary data of the user, to be able to interact with the device in a more efficient way, without the user having to bother having to enter them every time. This speeds up the process for the user himself and for the rest, in areas with a high demand for extractions.
  • the user's information is transmitted to the software of the device, being an option for this transmission, by reading a QR code generated by the application.
  • This software performs a validation of the QR code in real time, so that errors that may cause violations of information or data on other users are avoided. These data violations do occur in other machines that have a memory of validated codes, and in which it is necessary to carry out a first action on the machine for an initial validation, requiring the existence of a memory in charge of storing all the data of the codes validated during a certain period. Storing large amounts of information increases the risk of data breaches on machines that perform a large number of daily tests. This is not the case with the apparatus proposed here.
  • the apparatus may contain a QR code acceptor and a processor including a QR code verification module.
  • This module together with a communications unit, can be adapted to communicate with a QR code verification facility to obtain verification, including validation and authorization to purchase the analysis service.
  • This communication can be done through land lines or wireless systems, such as SMS or other similar system. It may also happen that two or more extraction devices are controlled by a terminal composed of a processor, a screen connected to it and software operable on said processor.
  • the software allows multiple blood tests to be performed from the devices in exchange for payment of a QR code authorization.
  • Each analysis unit is an automatic mini-operating room, which is a significant advantage, since it is possible to carry out the entire extraction process in a completely hygienic way, free from the presence of bacteria.
  • each device is assimilable to a laboratory, so that the use of extraction devices in the areas that require this analytical control is assimilated to the configuration of multiple blood analysis laboratories, with the possibility of carrying out tests fast efficient and safe. All this allows us to provide a solution to the problem that currently exists, through a unique tool to be able to control and manage a pandemic, thanks to the relationship between carrying out automatic and massive tests and obtaining information on the health status of individuals. with the possibility of real-time communication with health authorities.
  • the blood extraction process is carried out in a hygienic and safe way, without human intervention, since it is carried out completely automatically and with the added conditions that a cure and disinfection of the finger extraction area is carried out, for which for the user is a simple and comfortable process, as well as reliable and safe.
  • the unit of analysis proposed here is a tool for the care and control of health status.
  • the apparatus for extraction by means of it is interactive and allows the user the possibility of automatically performing the blood analysis test (without the need for medical personnel, autonomously), obtaining the result in seconds.
  • This extraction which is achieved by means of the analysis unit, guarantees the appropriate microbiological environmental conditions during the extraction and sanitation operation, a safe space, in optimal hygiene and disinfection conditions, configuring each analysis unit in a way that can be assimilated to an intelligent assistance mini-operating room. automatic.
  • the extraction carried out is painless, since the puncture for said extraction is carried out through the electronic piston stroke that multiplies by 10, the power and speed, with respect to any puncture device or lancet on the market. This makes the sensation of a slight prick imperceptible.
  • the information obtained is transferred to a computer application, so that the user can know and control the state of health quickly, usefully and effectively.
  • the extraction carried out supposes an optimal value for money, so it is accessible to any user, managing to cover the largest number of people. This allows countries to periodically and preventively recognize our state of health, making it a priority for the authorities to carry out control of their territory and their borders, thus achieving an effective defense system against viral threats and / or bacteriological.
  • the computer application linked to automatic analysis tests, provides an equally useful tool for monitoring and completely updated medical-scientific studies of the behavior of the virus, through a computerized system, obtaining global control of a possible pandemic. Real time.
  • Figures 1.1, 1.2 and 1.3.- Show perspective views, front elevation and dorsal elevation, respectively, of the sealed analysis unit for a first preferred embodiment of the invention.
  • Figures 2.1, 2.2 and 2.3.- Show respective exploded views of the first portion and an exploded perspective view from the opposite side of the second portion, of the sealed analysis unit, for a first preferred embodiment of the invention.
  • Figure 3.- Shows a perspective view of the second portion of the sealed analysis unit, for a preferred embodiment of the invention.
  • Figure 4.1, 4.2 and 4.3.- Shows side, bottom and exploded perspective views of the extraction device, for a first preferred embodiment of the invention.
  • Figures 5.1 to 5.3.- Show elevational and sectional views of different moments of extraction by means of the sealed analysis unit for a first preferred embodiment of the invention.
  • Figures 6.1 and 6.2.- Show perspective views from both sides of the sealed analysis unit for a second preferred embodiment of the invention.
  • Figure 7.- Shows an exploded view of the sealed analysis unit for a second preferred embodiment of the invention.
  • FIGS 8.1 and 8.2.- Show sectional views of the extraction apparatus for a first preferred embodiment of the invention.
  • Figures 9.1 and 9.2.- Show respective front and back perspective views, respectively, of the extraction apparatus for a second preferred embodiment of the invention.
  • Figure 10.- Shows a sectional view of the extraction apparatus for a second preferred embodiment of the invention.
  • Figures 11.1 to 11.4.- Show a section view and detail B of the same for different moments of extraction by means of the sealed analysis unit for a second preferred embodiment of the invention.
  • the analysis unit (A) seals a blood sample, for its evaluation by means of a diagnostic device, which is described here proposes comprises a first fixed portion (1) and a second portion (2) coupled to the first in a hermetically sealed and encapsulated manner, forming a sealed and germ-free analysis unit (A).
  • the first portion (1) as shown in Figure 2.1, has a sample extraction device (3) and a first opening (4) for access to it from the outside, while the second portion (2), as shown in Figures 2.2 and 3, it has a longitudinal cleaning device (5) fitted therein, arranged between the extraction device (3) and the first opening (4).
  • Said cleaning device (5) comprises a second opening (6), cleaning means for a puncture area on the user's finger, located on both sides of said second opening (6) and displacement means with respect to the first portion (1), following a direction from one end to the opposite end of the first opening (4), such that in a coincident position of the first and second openings (4, 6), allows access to the extraction device ( 3).
  • the cleaning device (5) is located at one end of the first opening (4), and when the extraction process begins, it begins to move towards the other end of it. , such that it passes over it and as the user's finger is trying to access the extraction device (3) through said first opening (4), the cleaning device (5) comes into contact with it.
  • the sanitizing means of the cleaning device (5) are formed by a first preparation zone and a second curing zone arranged on both sides of the second opening (6) respectively, consecutively and adjacent to it.
  • the sanitation means preparation area has a first element (7.1) formed by a wet disinfection towel and a second element (7.2) adjacent to the second opening ( 6) formed by a monofilament drying gauze, and the curing area has a third element (7.3) adjacent to the second opening (6), formed by a cleaning material, and a fourth element (7.4) formed by a gauze with healing gel.
  • the user's finger comes into contact with the preparation area, that is, first with the first element (7.1) and then with the second element (7.2) formed by the drying monofilament gauze.
  • the cleaning device (5) continues its movement in the same direction, so that the healing area of the sanitation means comes into contact with the recently punctured finger, for its healing, as shown in Figures 5.3. It first makes contact with the third element (7.3) of cleaning material and then with the fourth element (7.4) made of gauze with healing gel.
  • the extraction device (3) of this sealed analysis unit (A) comprises a sample receiving tank (8) arranged in a housing in the upper part thereof, in correspondence with the first opening (4). ) access to the outside of the first portion (1) and connected to a SIM integrated circuit card (9) arranged at one end of said extraction device (3).
  • It also has a first vertical through hole arranged through the extraction device (3) and the receiving tank (8) and a mechanism for executing a puncture in the user's finger by means of a hypodermic needle (10) arranged in the first hole. intern.
  • the puncture execution mechanism comprises, below the receiving tank (8), a striker (11) with a base (11.1) connected to the hypodermic needle (10) and to the least two longitudinal flanges (11.2) that emerge perpendicularly from the upper face of the base (11.1) of the firing pin and have a narrowing from an intermediate section to the free upper end of the same.
  • the execution mechanism also has some holes (12) for the passage of said tabs (11.2) around the first through hole and through the receiving tank housing (8), a first spring (13). ) in the narrowing of the striker (11), and a second spring (14) around the hypodermic needle (10), arranged between the housing and the base (11.1) of the striker (11) and the needle (10) respectively, such that they allow the return of both after the execution of the puncture, a retaining ring (15) and a conical hood (16) with a central hole for the passage of the hypodermic needle (10), arranged around the first through hole , on the upper face of the sample receiving tank (8).
  • a head (17) in the shape of a cylindrical crown that has at least two holes at its base for the passage of the flanges (11.2) of the striker (11) and on its upper face it has at least three projections (18) curvilinear to press the extraction area on the user's finger. These projections (18) go to facilitate a faster blood outflow to be able to perform the puncture for the shortest possible time.
  • the first portion (1) has a cylindrical shape with a first base (1.1) and a second base (1.2) opposite and open, both arranged vertically, such that the lower and upper ends are curved.
  • This first portion (1) has a central cylindrical body (19) open towards the first base (1.1), which emerges from it and protrudes from the second base (1.2).
  • the first opening (4) of this first portion (1) is arranged in the lower part of said central cylindrical body (19).
  • this first portion (1) comprises a longitudinal channel (20), suitable for housing the extraction device (3) inside it, located through the lower end of the first portion (1), with both ends opposite sides thereof open, and where respective upper and lower faces thereof have a through hole coinciding with the first opening (4).
  • Figures 4.1 and 4.2 show said extraction device (3) which is located inside the longitudinal channel (20).
  • the second portion (2) has a cylindrical shape with dimensions such that it is externally attachable to the first portion (1), with a first base (2.1) and to the least one segment (21.1) of its lateral surface (21) open and a central ring (22) of dimensions such that it is adjustable around the central cylindrical body (19) of the first portion (1), being in this central ring (22 ) where the cleaning device (5) is embedded, in correspondence with the open segment of the lateral surface (21) of the second portion (2).
  • the extraction device (3) has a longitudinal shape and displacement means along its main axis along the longitudinal channel (20) of the first portion (1) and the cleaning device (5) is arch-shaped.
  • the movement means of the extraction device (3) allow that once the puncture has been carried out and the necessary amount of blood has been extracted, it can be moved so that the SIM card comes into contact with the diagnostic device (27), so that the same can be done.
  • the sealed analysis unit (A) has a first portion (1) with a prismatic shape that has an open upper face (1.3), a lower face (1.4), a first and second opposite ends (1.5, 1.6), and two sides.
  • This first portion (1) comprises the extraction device (3) fixed inside, centered and accessible from the upper face (1.3), a connection to the SIM card (9) that is located at the second end (1.6). ), a longitudinal groove (23) inside with an opening at the first end (1.5), arranged parallel to the upper face (1.3) and accessible from it and a cover (24) of said upper face (1 -3 ).
  • the first opening (4) of this first portion (1) is arranged in said cover (24), in correspondence with the vertical through hole of the extraction device (3).
  • the second portion (2) has a shape adapted to the shape of the longitudinal slot (23), such that it allows its watertight and airtight fit therein and has means of displacement along said slot (23).
  • the second portion (2) has a cleaning device (5) embedded in it, with sanitation means, and arranged initially at one end of the first opening (4).
  • FIGs 11.1 and 11.2 a position of the sanitation means is shown in which they have begun to move towards the other end of the first opening (4), so that the first element (7.1) of the first preparation area of the same comes into contact with the user's finger.
  • Figure 11 .2 shows the position of the sanitation facilities in detail.
  • the extraction device (3) punctures the user's finger, since it is the only moment in which there is communication between the extraction device (3) and said first opening (4).
  • the cleaning device (5) continues its movement so that, as shown in Figure 11.4, the third element (7.3) of the sanitation means comes into contact with the user's finger, to perform the cure of the area in which the extraction has been carried out.
  • the sealed analysis unit (A) comprises a reactive strip with qualitative, quantitative and semi-quantitative analysis connected to the sample receiving tank (8). In this way it is possible to triangulate the results obtained, resulting in a more complete and conclusive diagnosis of the user's health status.
  • the device comprises an external casing (25) with an extraction zone that has a third opening (26) for access to the interior of the device and, inside which it comprises at least one storage unit.
  • the extraction apparatus further comprises a diagnostic device (27) with means of connection to the SIM card (9) of the waterproof analysis unit (A) which is located in the extraction area, a microprocessor with software (28 ) from control connected to the diagnostic device (27), and to the means for moving the second portion (2) with respect to the first, and an internal memory connected to the control software (28).
  • this extraction apparatus comprises a plurality of analysis units (A) sealed inside, as well as storage means for them, supply means of these to the extraction area of the apparatus and subsequent removal to an internal waste area (31).
  • this extraction apparatus of the first preferred embodiment comprises means for wireless connection with an electronic device that has a computer application configured to interact with the apparatus and means for activating the apparatus connected to the control software (28).
  • the storage means and the supply means of the sealed analysis units (A) are also connected to the control software (28).
  • the storage means for the sealed analysis units (A) are made up of platforms (29) for containing them, as shown in Figures 8.1 and 8.2, which have opposite extremes.
  • the means for supplying and subsequently withdrawing these analysis units are formed, in this first preferred embodiment, by vertical sliding guides (30) arranged at both ends of the platforms (29), means of connection of the ends of said platforms (29) to the sliding guides (30) and electric motors connected to the software (28) and to the ends of the platforms (29), such that they allow a vertical displacement of one or the other end of independently, so that the determined inclination of the platform (29) allows the analysis units (A) to slide towards the end located at a lower level, this being an internal waste area (31).
  • said vertical sliding guides (30) extend towards the lower part of the device, such that they are arranged in the internal waste area (31), so that they contain the analysis units (A) sealed used.
  • the extraction device further comprises wireless connection means with an electronic device that has a computer application configured to interact with the device and means for activating the device connected to the control software (28).
  • the device activation means comprise a presence sensor and a camera (32) connected to the software (28).
  • This extraction apparatus of this first preferred embodiment comprises means for activating an upward vertical movement of the execution mechanism of the extraction device (3) of a sealed analysis unit (A), connected to the software (28) of the apparatus. , and said drive means are mechanical.
  • This device has the advantage that it can be easily moved and placed at critical points of flow of people where a quick and reliable diagnosis is required, in order to allow them to pass or not.
  • the apparatus comprises a QR code reader device (33) connected to the software (28), in this way, it is possible to start the extraction process by the user only by showing an existing QR code in an application configured to communicate with this device and installed on a mobile device, the device can access all the user data it needs, without the user having to enter them one by one into the device.
  • this apparatus is capable of issuing a safe, rapid diagnosis without human intervention, and comprises a printing device (34) for cards with QR code connected to the software (28), so that said code contains the diagnosis that will serve for the user to demonstrate their health status and safely access the checkpoint for everyone. You can also broadcast a message that is sent to the mobile device application.
  • the extraction apparatus further comprises, in an area of the casing, an interior storage space for transport elements, such as bags, to move the used sealed analysis units (A) to a safe point. waste of them.
  • the blood sample extraction apparatus is such that the casing (25) has a manual support area (35) of the itself, so that it is easily manageable by one person with one hand. It also has an open chamber (36) at the top in its upper part, of such dimensions that it allows the insertion of a sealed analysis unit (A) inside it.
  • This apparatus comprises inside a diagnostic device (27) with a connection to the SIM card (9) of the watertight analysis unit (A), the analysis unit being as defined in the second embodiment proposed in this memory.
  • the apparatus comprises control software (28) connected to the diagnostic device (27) and to the means for moving the second portion (2) with respect to the first portion (1) of the sealed analysis unit (A). , and manual activation means of the apparatus connected to the control software (28).
  • the extraction apparatus also has an open chamber (36) at the top in the upper part of the casing (25), of dimensions such that it allows the insertion of an analysis unit (A) inside it.
  • the apparatus comprises means for actuating an upward vertical movement of the execution mechanism of the extraction device (3) of a sealed analysis unit (A), and said drive means are manual.
  • this apparatus may have mechanical drive means.
  • the extraction devices comprise control means formed by a screen (37) and commands connected to the control software (28), so that it is easily operable by the user.
  • thermometer means for measuring the user's temperature, formed by a laser thermometer (38) connected to the software (28).
  • the extraction apparatus comprises connection means via the Internet to a central server.
  • connection means via the Internet to a central server.
  • the apparatus of the first embodiment can have power supply means through a connection to the electrical network or through a rechargeable battery.
  • its power supply is by means of a battery (39) that can also be rechargeable.

Abstract

L'invention concerne une unité d'analyse (A) étanche de sang, qui comprend une première partie (1) fixe avec un dispositif d'extraction (3) et une première ouverture (4), et; une seconde partie (2) couplée à la précédente de manière hermétique et encapsulée, avec un dispositif de nettoyage (5) entre le dispositif d'extraction (3) et la première ouverture (4), qui comprend une seconde ouverture (6), des moyens d'assainissement et, des moyens de déplacement qui permettent l'accès au dispositif d'extraction (3), lorsque les première et seconde ouvertures (4, 6) coïncident. L'invention concerne également un appareil d'extraction de sang au moyen d'une unité d'analyse, avec un boîtier (25) qui contient au moins une unité d'analyse (A) étanche; un microprocesseur avec un logiciel (28) de commande relié à un dispositif de diagnostic (27), à une mémoire, et à un dispositif de déplacement de la seconde partie (2) par rapport à la première.
PCT/ES2021/070465 2020-09-18 2021-06-23 Système de contrôle de diagnostic avec dispositif automatique d'extraction, d'assainissement et d'analyse d'échantillon biologique WO2022058633A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ESP202030947 2020-09-18
ES202030947A ES2916402B2 (es) 2020-09-18 2020-09-18 Sistema de control diagnostico con dispositivo automatico de extraccion, saneamiento y analisis de muestra biologica

Publications (1)

Publication Number Publication Date
WO2022058633A1 true WO2022058633A1 (fr) 2022-03-24

Family

ID=80775952

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/ES2021/070465 WO2022058633A1 (fr) 2020-09-18 2021-06-23 Système de contrôle de diagnostic avec dispositif automatique d'extraction, d'assainissement et d'analyse d'échantillon biologique

Country Status (2)

Country Link
ES (1) ES2916402B2 (fr)
WO (1) WO2022058633A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023180967A1 (fr) 2022-03-23 2023-09-28 Crispr Therapeutics Ag Cellules car-t anti-cd83 portant une perturbation de regnase-1 et/ou tgfbrii

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4452243A (en) * 1981-07-20 1984-06-05 Cloverline, Inc. Sanitary blood lancet device
US20040138588A1 (en) * 2002-11-06 2004-07-15 Saikley Charles R Automatic biological analyte testing meter with integrated lancing device and methods of use
US20080228107A1 (en) * 2007-03-12 2008-09-18 Venkateshwara N Reddy Bio-testing booth
US20090191617A1 (en) * 2008-01-25 2009-07-30 Lg Electronics Inc. Bio chip and related technologies including apparatus for analyzing biological material
US20150134347A1 (en) * 2013-05-24 2015-05-14 LabATM INC. Self-serve kiosk for blood /fluid/tissue collection and screening
CN209377586U (zh) * 2018-12-21 2019-09-13 敬善生物科技江苏有限公司 指尖采血装置

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4452243A (en) * 1981-07-20 1984-06-05 Cloverline, Inc. Sanitary blood lancet device
US20040138588A1 (en) * 2002-11-06 2004-07-15 Saikley Charles R Automatic biological analyte testing meter with integrated lancing device and methods of use
US20080228107A1 (en) * 2007-03-12 2008-09-18 Venkateshwara N Reddy Bio-testing booth
US20090191617A1 (en) * 2008-01-25 2009-07-30 Lg Electronics Inc. Bio chip and related technologies including apparatus for analyzing biological material
US20150134347A1 (en) * 2013-05-24 2015-05-14 LabATM INC. Self-serve kiosk for blood /fluid/tissue collection and screening
CN209377586U (zh) * 2018-12-21 2019-09-13 敬善生物科技江苏有限公司 指尖采血装置

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023180967A1 (fr) 2022-03-23 2023-09-28 Crispr Therapeutics Ag Cellules car-t anti-cd83 portant une perturbation de regnase-1 et/ou tgfbrii

Also Published As

Publication number Publication date
ES2916402B2 (es) 2023-05-11
ES2916402A1 (es) 2022-06-30

Similar Documents

Publication Publication Date Title
US20060094028A1 (en) Rapid diagnostic assay
CN104582596A (zh) 集成注射系统和通信装置
AU2021203651A1 (en) Multiplex bead array assay
EP3800264B1 (fr) Dispositif de culture réutilisable jetable portatif pour le diagnostic rapide d'agents infectieux
US20190053454A1 (en) Diagnostics systems and methods
ES2916402B2 (es) Sistema de control diagnostico con dispositivo automatico de extraccion, saneamiento y analisis de muestra biologica
US20190091687A1 (en) Safe blood pregnancy test at home
CN109922732B (zh) 诊断系统和方法
ES2205459T3 (es) Dispositivo de analisis y de registro.
US20220228100A1 (en) Portable disposable re-usable culture device for rapid diagnosis of infectious agents
US9588118B2 (en) Devices for performing colorimetric assay with plucked human hair
US20160348056A1 (en) Portable disposable re-usable culture device for rapid diagnosis of infectious agents
CN114886473A (zh) 多腔室体液采集装置及区块链健康管理系统
WO2021219491A1 (fr) Dispositif d'auto-test jetable à capacité d'auto-certification et kit le contenant
GB2603048A (en) Packaging box
Erickson Saliva reveals all
WO2015015462A1 (fr) Système télématique de collecte et de traitement de données et de résultats de tests d'auto-diagnostic dans une population d'utilisateurs, procédé correspondant, dispositif électronique périphérique de service et kit d'auto-diagnostic conçu pour être utilisé dans un tel système télématique

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 21868782

Country of ref document: EP

Kind code of ref document: A1

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 21868782

Country of ref document: EP

Kind code of ref document: A1