WO2022039700A1 - An immune-enhancer and anti-ageing nutraceutical or pharmaceutical composition - Google Patents

An immune-enhancer and anti-ageing nutraceutical or pharmaceutical composition Download PDF

Info

Publication number
WO2022039700A1
WO2022039700A1 PCT/TR2021/050798 TR2021050798W WO2022039700A1 WO 2022039700 A1 WO2022039700 A1 WO 2022039700A1 TR 2021050798 W TR2021050798 W TR 2021050798W WO 2022039700 A1 WO2022039700 A1 WO 2022039700A1
Authority
WO
WIPO (PCT)
Prior art keywords
weight
nutraceutical
homogeneous
value
component
Prior art date
Application number
PCT/TR2021/050798
Other languages
French (fr)
Inventor
Hakan BASLIK
Original Assignee
Hakan Baslik Karya Farma Hbx Ar-Ge Tibbi Aromatik Bitkiler
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hakan Baslik Karya Farma Hbx Ar-Ge Tibbi Aromatik Bitkiler filed Critical Hakan Baslik Karya Farma Hbx Ar-Ge Tibbi Aromatik Bitkiler
Publication of WO2022039700A1 publication Critical patent/WO2022039700A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/57—Magnoliaceae (Magnolia family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
    • A61K36/605—Morus (mulberry)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/66—Papaveraceae (Poppy family), e.g. bloodroot
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed

Definitions

  • the invention relates to an immune-enhancer and anti-ageing nutraceutical or pharmaceutical composition with the herbal-based components included therein in certain percentages by weight.
  • Old age is defined as a stage in which physical and mental changes are seen in the later period of life as an extension of adulthood. Old age defined in this way in general is accepted as a period in which different criteria such as physiological changes, psycho-social factors and chronology are taken into account in the definition.
  • Free radicals, decreasing hormones, exposure of the skin to UV rays, sedentary life, smoking, stress and unhealthy nutrition are the main causes of early ageing.
  • the skin which is directly affected by the environment and lifestyle, is the organ in which the signs of ageing are seen the most.
  • Biochemical function changes in the human body with ageing cause changes in many periods from cells to organs. Along with these extremely complex changes, the immune system naturally ages.
  • the present invention relates to a nutraceutical or pharmaceutical composition in order to eliminate the above-mentioned disadvantages and bring new advantages to the related technical field.
  • a purpose of the invention is to propound an anti-ageing nutraceutical or pharmaceutical composition.
  • a purpose of the invention is to propound a completely herbal-based nutraceutical or pharmaceutical composition without any side effects.
  • the present invention relates to a homogeneous immune-enhancer and anti-ageing nutraceutical or pharmaceutical composition in order to achieve all purposes which were mentioned above and will emerge from the detailed description below.
  • said homogeneous nutraceutical or pharmaceutical composition contains completely herbalbased hot pepper, black mulberry, anise, stinging nettle, fig, olive, semen pegani, mistletoe and poppy components. In this way, it is possible to obtain anti-ageing fatty acid and phenolic compounds for the human body.
  • the homogeneous composition contains hot pepper component at a value between 1% to 15% by weight; black mulberry component at a value between 1% to 15% by weight; anise component at a value between 1% to 15% by weight; stinging nettle component at a value between 1% to 15% by weight; fig component at a value between 1% to 15% by weight; olive component at a value between 1% to 15% by weight; semen pegani at a value between 1% to 15% by weight; mistletoe at a value between 1% to 15% by weight; and poppy seed at a value between 1% to 15% by weight.
  • the homogeneous composition contains the hemp oil component as a solvent in certain percentages by weight.
  • the homogeneous composition contains the hemp oil component as a solvent in certain percentages by weight.
  • the homogeneous composition has a weight ratio of homogeneous composition/hemp oil in the range of 1 :2 to 1 :4.
  • the possible embodiment of the invention is that the homogeneous composition additionally contains one or more various auxiliary products. Thus, it is ensured that the effect of the nutraceutical or pharmaceutical composition to be obtained in the invention is increased.
  • the homogeneous composition contains additionally at least one other active ingredient with anti-ageing feature.
  • the possible embodiment of the invention is that the homogeneous composition can be formulated in solid or liquid dosage forms.
  • the possible embodiment of the invention is that the homogeneous composition can be formulated in dosage forms suitable for intake by injection.
  • the possible embodiment of the invention is that if the homogeneous composition is formulated in dosage forms suitable for intake by injection, said dosage form can be formulated in one of the dosage forms suitable for intradermal, intramuscular, intravenous, abdominal administration.
  • the possible embodiment of the invention is that the homogeneous composition can be formulated in dosage forms suitable for cutaneous intake.
  • the subject of the invention relates to an immune-enhancer and anti-aging (anti-ageing agent (AAA)) nutraceutical or pharmaceutical composition due to the herbal-based components contained therein in certain percentages by weight; it is only explained with examples that will not have any limiting effect for a better understanding of the subject.
  • AAA anti-ageing agent
  • the nutraceutical or pharmaceutical composition obtained in the invention contains completely herbal-based components.
  • the mentioned components contain high amounts of fatty acids and phenolic compounds. It is known from studies in the literature that the mentioned fatty acid and phenolic components are important for the human body in terms of providing anti-ageing feature.
  • the nutraceutical or pharmaceutical composition obtained in the invention does not have any toxic side effects to the human body, since it contains completely herbal-based components.
  • the pharmaceutical or nutraceutical composition contains hot pepper component, which contains beta carotene, antioxidant, vitamin C and the primary active ingredient capsaicin.
  • Capsaicin which is the active ingredient of hot pepper, has a pain-relieving and pleasing effect in the body as it stimulates the secretion of endorphins in the brain.
  • the hot pepper strengthens the immune system with its antioxidants; and it is also among the vegetables with the strongest anti-carcinogenic effect.
  • the nutraceutical composition contains black mulberry component, which is a very powerful antioxidant with meeting most of the daily iron mineral needs, in addition to being rich in vitamins A, B and K.
  • the mentioned black mulberry contains beta carotene, alpha carotene, fiber, magnesium, calcium, and potassium minerals.
  • the nutraceutical composition contains star anise component with strong antioxidant, antiseptic, antifungal effect.
  • the star anise component contains high amount of shikimic acid.
  • the nutraceutical composition contains stinging nettle component, which contains vitamins A, B and K, riboflavin, niacin, folate, phosphorus, carbohydrates, fat and proteins, and also has a strong antioxidant effect.
  • the nutraceutical composition contains vitamins A, K and E, magnesium, iron and calcium minerals and fresh fig component with high antioxidant feature.
  • the fig also contains structures rich in natural sugars and soluble fibers.
  • the nutraceutical composition contains the olive component, which plays a role in cleaning up the high amounts of free radical molecules and has an anti-carcinogenic effect by containing a-tocopherol and phenols.
  • the nutraceutical composition contains semen pegani, which contains high amounts of alkaloids and fatty acids, as well as vitamins A and C.
  • the nutraceutical composition contains mistletoe, which contains high amount of vitamin A, amount of oil, magnesium mineral and iron minerals.
  • the nutraceutical composition contains poppy seeds, which contain high amounts of minerals such as omega-3, zinc, potassium, manganese, and copper.
  • the common feature of all the components included in the nutraceutical composition of the invention is that they contain high amount of fatty acid, mineral and phenolic compounds. With the inclusion of said components in the composition, anti-ageing features are provided. As is known in the art, fatty acid and phenolic compounds provide anti-ageing features for the human body.
  • the pharmaceutical or nutraceutical composition of the invention has a completely herbalbased structure that does not have any toxic effect if applied to the patient.
  • the pharmaceutical or nutraceutical composition contains red hot pepper component at a value between 1% to 15% by weight; black mulberry component at a value between 1 % to 15% by weight; anise component at a value between 1% to 15% by weight; stinging nettle component at a value between 1% to 15% by weight; fig component at a value between 1 % to 15% by weight; olive component at a value between 1 % to 15% by weight; semen pegani at a value between 1 % to 15% by weight; mistletoe at a value between 1 % to 15% by weight; poppy seed at a value between 1 % to 15% by weight, at a total weight of 100%.
  • All the components used in obtaining the nutraceutical or pharmaceutical composition are first brought together in the percentages by weight mentioned above, and a homogeneous mixture in powder form is achieved by means of a mixer. Another mixture is formed by adding 2 liters of hemp oil to the 1 -kilogram weight of the homogeneous mixture obtained. The homogeneous powder mixture/hemp oil mixture obtained in this way is kept for at least 19 days. The mixture is mixed by means of a mixer three times a day for at least 19 days. The obtained mixture is then put into a pumpkin; and kept here for at least 19 days too. After this process, the oil accumulated on the upper part of the mixture in the pumpkin is taken to be used in the nutraceutical or pharmaceutical composition extraction.
  • anti-ageing agent used within the scope of the present invention is used to mean a combination that prevents or restricts the events that bring about structural and functional changes and cell death of the human organism that occur under the influence of environmental factors or are regulated by a genetic program.
  • the present invention relates to the use of pharmaceutical or nutraceutical homogeneous mixture as anti-ageing agent and immune-enhancer agent.
  • the pharmaceutical or nutraceutical homogeneous mixture also has activity as an antibacterial, antifungal, antiviral, immune-enhancer, anti-carcinogenic, antiparasitic agent.
  • the possible embodiment of the invention is that the homogeneous pharmaceutical or nutraceutical composition can be formulated in solid or liquid dosage forms. In this way, the pharmaceutical or nutraceutical composition obtained by the invention is ensured to be taken into the body in the most effective way.
  • the possible embodiment of the invention is that the homogeneous pharmaceutical or nutraceutical composition can be formulated in dosage forms suitable for intake by injection into the body.
  • the possible embodiment of the invention is that if the homogeneous pharmaceutical or nutraceutical composition is formulated in dosage forms suitable for intake by injection, said dosage form can be formulated in one of the dosage forms suitable for intradermal, intramuscular, intravenous, abdominal administration.
  • the pharmaceutical or nutraceutical composition obtained by the invention is ensured to be taken into the body in the most effective way.
  • the possible embodiment of the invention is that the homogeneous pharmaceutical or nutraceutical composition can be formulated in dosage forms suitable for intake through the skin.
  • Fats included in the nutraceutical or pharmaceutical composition obtained in the invention are saturated fatty acid at the ratio of 84,25% and unsaturated fatty acid at the ratio of 14,25%.
  • the weight percentage of fatty acids in the composition is given in Table 1 in detail.
  • Omega 3, 6, 9 fatty acids are the most common fatty acids in the composition.
  • the nutraceutical or pharmaceutical composition obtained in the invention contains high amounts of fatty acid, zinc, iron, phosphorus and potassium minerals. Accordingly, structural analysis results of the obtained composition are given in Table 2.
  • the nutraceutical or pharmaceutical composition obtained as an anti-ageing agent contains high amounts of mineral and fatty acid. These mentioned mineral, fatty acid and phenolic compounds are known to be important compounds in obtaining the anti-ageing agent, the nutraceutical or pharmaceutical composition extraction with high amount of these nutritional values is provided for the relevant technical field.
  • HBX-HGM71 AAA
  • HBX-HGM71 (AAA) is a powerful agent obtained by combining many antioxidant-rich components, regarding strengthening the immune system in the most effective way.
  • the obtained composition is very rich in omega 3, 6, 9 fatty acids, as shown in Table 1 .
  • HBX-HGM71 The main purpose of HBX-HGM71 (AAA) is to understand the biology of ageing and to increase the quality of life and to try to extend it with interventions that improve general health. Vitamin, mineral, cholesterol, triglyceride and hormone levels are determined by blood and hormone tests. Healthy people are supported with anti-ageing applications, and treatment is supported in the presence of disease. HBX-HGM71 (AAA) is a physical oil extraction and consists of very rich components.
  • the inventors present the data confirming the pharmaceutical or nutraceutical homogeneous mixture structure to your attention in this application. Considering all these presented data and the state of the art, it is seen that the pharmaceutical or nutraceutical homogeneous mixtures appropriate for the invention are a new mixture that has not been disclosed before in the state of the art. It is shown that the mixture appropriate for the present invention is new and has an inventive step by surpassing the state of the art.

Landscapes

  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biotechnology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Medical Informatics (AREA)
  • Botany (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

The present invention relates to an immune-enhancer and anti-ageing homogeneous nutraceutical or pharmaceutical composition. Accordingly, said homogeneous nutraceutical or pharmaceutical composition contains completely herbal-based hot pepper, black mulberry, anise, stinging nettle, fig, olive, semen pegani, mistletoe and poppy components. In this way, it is possible to obtain anti-ageing fatty acids and phenolic compounds for the human body.

Description

AN IMMUNE-ENHANCER AND ANTI-AGEING NUTRACEUTICAL OR PHARMACEUTICAL COMPOSITION
TECHNICAL FIELD
The invention relates to an immune-enhancer and anti-ageing nutraceutical or pharmaceutical composition with the herbal-based components included therein in certain percentages by weight.
PRIOR ART
Old age is defined as a stage in which physical and mental changes are seen in the later period of life as an extension of adulthood. Old age defined in this way in general is accepted as a period in which different criteria such as physiological changes, psycho-social factors and chronology are taken into account in the definition.
Free radicals, decreasing hormones, exposure of the skin to UV rays, sedentary life, smoking, stress and unhealthy nutrition are the main causes of early ageing. The skin, which is directly affected by the environment and lifestyle, is the organ in which the signs of ageing are seen the most.
Biochemical function changes in the human body with ageing cause changes in many periods from cells to organs. Along with these extremely complex changes, the immune system naturally ages.
As it is known in the art, it is possible to slow down the ageing process with certain methods. By means of anti-ageing applications, which are part of preventive medicine, the energy of cells is increased; the ageing process of the skin is slowed down with cosmetic care.
Today, the operations made to prevent old age is generally the use of synthetic drugs or the application of aesthetic operations. The mentioned drugs and aesthetic operations are external measures done for the human body. Vegetables and fruits, which are used as herbal-based nutraceutical compositions, can be used as anti-ageing applications due to the antioxidant compounds contained therein. This method is a completely natural method and it is to ensure that the compounds the body needs are taken in one respect. As a result, it is aimed to use natural methods as anti-ageing, to prevent the use of surgical operations and synthetic drugs to which the body may react as mentioned earlier with the invention. It is anticipated that the herbal-based nutraceutical or pharmaceutical compositions obtained for this purpose will meet the innovation criteria for the relevant technical field.
BRIEF DESCRIPTION OF THE INVENTION
The present invention relates to a nutraceutical or pharmaceutical composition in order to eliminate the above-mentioned disadvantages and bring new advantages to the related technical field.
A purpose of the invention is to propound an anti-ageing nutraceutical or pharmaceutical composition.
A purpose of the invention is to propound a completely herbal-based nutraceutical or pharmaceutical composition without any side effects.
The present invention relates to a homogeneous immune-enhancer and anti-ageing nutraceutical or pharmaceutical composition in order to achieve all purposes which were mentioned above and will emerge from the detailed description below. Accordingly, said homogeneous nutraceutical or pharmaceutical composition contains completely herbalbased hot pepper, black mulberry, anise, stinging nettle, fig, olive, semen pegani, mistletoe and poppy components. In this way, it is possible to obtain anti-ageing fatty acid and phenolic compounds for the human body.
A possible embodiment of the invention is that the homogeneous composition contains hot pepper component at a value between 1% to 15% by weight; black mulberry component at a value between 1% to 15% by weight; anise component at a value between 1% to 15% by weight; stinging nettle component at a value between 1% to 15% by weight; fig component at a value between 1% to 15% by weight; olive component at a value between 1% to 15% by weight; semen pegani at a value between 1% to 15% by weight; mistletoe at a value between 1% to 15% by weight; and poppy seed at a value between 1% to 15% by weight.
The possible embodiment of the invention is that the homogeneous composition contains the hemp oil component as a solvent in certain percentages by weight. Thus, it is possible to obtain an anti-ageing nutraceutical or pharmaceutical composition in liquid form.
The possible embodiment of the invention is that the homogeneous composition has a weight ratio of homogeneous composition/hemp oil in the range of 1 :2 to 1 :4.
The possible embodiment of the invention is that the homogeneous composition additionally contains one or more various auxiliary products. Thus, it is ensured that the effect of the nutraceutical or pharmaceutical composition to be obtained in the invention is increased.
The possible embodiment of the invention is that the homogeneous composition contains additionally at least one other active ingredient with anti-ageing feature.
The possible embodiment of the invention is that the homogeneous composition can be formulated in solid or liquid dosage forms.
The possible embodiment of the invention is that the homogeneous composition can be formulated in dosage forms suitable for intake by injection.
The possible embodiment of the invention is that if the homogeneous composition is formulated in dosage forms suitable for intake by injection, said dosage form can be formulated in one of the dosage forms suitable for intradermal, intramuscular, intravenous, abdominal administration.
The possible embodiment of the invention is that the homogeneous composition can be formulated in dosage forms suitable for cutaneous intake.
DETAILED DESCRIPTION OF THE INVENTION
In this detailed description, the subject of the invention relates to an immune-enhancer and anti-aging (anti-ageing agent (AAA)) nutraceutical or pharmaceutical composition due to the herbal-based components contained therein in certain percentages by weight; it is only explained with examples that will not have any limiting effect for a better understanding of the subject.
The nutraceutical or pharmaceutical composition obtained in the invention contains completely herbal-based components. The mentioned components contain high amounts of fatty acids and phenolic compounds. It is known from studies in the literature that the mentioned fatty acid and phenolic components are important for the human body in terms of providing anti-ageing feature.
The nutraceutical or pharmaceutical composition obtained in the invention does not have any toxic side effects to the human body, since it contains completely herbal-based components.
The pharmaceutical or nutraceutical composition contains hot pepper component, which contains beta carotene, antioxidant, vitamin C and the primary active ingredient capsaicin. Capsaicin, which is the active ingredient of hot pepper, has a pain-relieving and pleasing effect in the body as it stimulates the secretion of endorphins in the brain. The hot pepper strengthens the immune system with its antioxidants; and it is also among the vegetables with the strongest anti-carcinogenic effect.
The nutraceutical composition contains black mulberry component, which is a very powerful antioxidant with meeting most of the daily iron mineral needs, in addition to being rich in vitamins A, B and K. The mentioned black mulberry contains beta carotene, alpha carotene, fiber, magnesium, calcium, and potassium minerals.
The nutraceutical composition contains star anise component with strong antioxidant, antiseptic, antifungal effect. The star anise component contains high amount of shikimic acid.
The nutraceutical composition contains stinging nettle component, which contains vitamins A, B and K, riboflavin, niacin, folate, phosphorus, carbohydrates, fat and proteins, and also has a strong antioxidant effect.
The nutraceutical composition contains vitamins A, K and E, magnesium, iron and calcium minerals and fresh fig component with high antioxidant feature. The fig also contains structures rich in natural sugars and soluble fibers.
The nutraceutical composition contains the olive component, which plays a role in cleaning up the high amounts of free radical molecules and has an anti-carcinogenic effect by containing a-tocopherol and phenols.
The nutraceutical composition contains semen pegani, which contains high amounts of alkaloids and fatty acids, as well as vitamins A and C. The nutraceutical composition contains mistletoe, which contains high amount of vitamin A, amount of oil, magnesium mineral and iron minerals.
The nutraceutical composition contains poppy seeds, which contain high amounts of minerals such as omega-3, zinc, potassium, manganese, and copper.
The common feature of all the components included in the nutraceutical composition of the invention is that they contain high amount of fatty acid, mineral and phenolic compounds. With the inclusion of said components in the composition, anti-ageing features are provided. As is known in the art, fatty acid and phenolic compounds provide anti-ageing features for the human body.
The pharmaceutical or nutraceutical composition of the invention has a completely herbalbased structure that does not have any toxic effect if applied to the patient. The pharmaceutical or nutraceutical composition contains red hot pepper component at a value between 1% to 15% by weight; black mulberry component at a value between 1 % to 15% by weight; anise component at a value between 1% to 15% by weight; stinging nettle component at a value between 1% to 15% by weight; fig component at a value between 1 % to 15% by weight; olive component at a value between 1 % to 15% by weight; semen pegani at a value between 1 % to 15% by weight; mistletoe at a value between 1 % to 15% by weight; poppy seed at a value between 1 % to 15% by weight, at a total weight of 100%.
All the components used in obtaining the nutraceutical or pharmaceutical composition are first brought together in the percentages by weight mentioned above, and a homogeneous mixture in powder form is achieved by means of a mixer. Another mixture is formed by adding 2 liters of hemp oil to the 1 -kilogram weight of the homogeneous mixture obtained. The homogeneous powder mixture/hemp oil mixture obtained in this way is kept for at least 19 days. The mixture is mixed by means of a mixer three times a day for at least 19 days. The obtained mixture is then put into a pumpkin; and kept here for at least 19 days too. After this process, the oil accumulated on the upper part of the mixture in the pumpkin is taken to be used in the nutraceutical or pharmaceutical composition extraction.
The expression "anti-ageing agent" used within the scope of the present invention is used to mean a combination that prevents or restricts the events that bring about structural and functional changes and cell death of the human organism that occur under the influence of environmental factors or are regulated by a genetic program.
The present invention relates to the use of pharmaceutical or nutraceutical homogeneous mixture as anti-ageing agent and immune-enhancer agent. The pharmaceutical or nutraceutical homogeneous mixture also has activity as an antibacterial, antifungal, antiviral, immune-enhancer, anti-carcinogenic, antiparasitic agent.
The possible embodiment of the invention is that the homogeneous pharmaceutical or nutraceutical composition can be formulated in solid or liquid dosage forms. In this way, the pharmaceutical or nutraceutical composition obtained by the invention is ensured to be taken into the body in the most effective way.
The possible embodiment of the invention is that the homogeneous pharmaceutical or nutraceutical composition can be formulated in dosage forms suitable for intake by injection into the body.
The possible embodiment of the invention is that if the homogeneous pharmaceutical or nutraceutical composition is formulated in dosage forms suitable for intake by injection, said dosage form can be formulated in one of the dosage forms suitable for intradermal, intramuscular, intravenous, abdominal administration. The pharmaceutical or nutraceutical composition obtained by the invention is ensured to be taken into the body in the most effective way.
The possible embodiment of the invention is that the homogeneous pharmaceutical or nutraceutical composition can be formulated in dosage forms suitable for intake through the skin.
Fats included in the nutraceutical or pharmaceutical composition obtained in the invention are saturated fatty acid at the ratio of 84,25% and unsaturated fatty acid at the ratio of 14,25%. The weight percentage of fatty acids in the composition is given in Table 1 in detail.
Omega 3, 6, 9 fatty acids are the most common fatty acids in the composition.
Figure imgf000007_0001
Figure imgf000008_0001
Table 1. Structural Analysis of Fats Involved in Nutraceutical or Pharmaceutical Composition
The nutraceutical or pharmaceutical composition obtained in the invention contains high amounts of fatty acid, zinc, iron, phosphorus and potassium minerals. Accordingly, structural analysis results of the obtained composition are given in Table 2.
Figure imgf000008_0002
Table 2. Structure Analysis Results of the Nutraceutical or Pharmaceutical Composition Obtained in the Invention
As can be seen from the data in the tables, the nutraceutical or pharmaceutical composition obtained as an anti-ageing agent contains high amounts of mineral and fatty acid. These mentioned mineral, fatty acid and phenolic compounds are known to be important compounds in obtaining the anti-ageing agent, the nutraceutical or pharmaceutical composition extraction with high amount of these nutritional values is provided for the relevant technical field.
The nutraceutical or pharmaceutical composition obtained in the invention is referred to by the reference name HBX-HGM71 (AAA).
HBX-HGM71 (AAA) is a powerful agent obtained by combining many antioxidant-rich components, regarding strengthening the immune system in the most effective way. The obtained composition is very rich in omega 3, 6, 9 fatty acids, as shown in Table 1 .
The main purpose of HBX-HGM71 (AAA) is to understand the biology of ageing and to increase the quality of life and to try to extend it with interventions that improve general health. Vitamin, mineral, cholesterol, triglyceride and hormone levels are determined by blood and hormone tests. Healthy people are supported with anti-ageing applications, and treatment is supported in the presence of disease. HBX-HGM71 (AAA) is a physical oil extraction and consists of very rich components.
The inventors present the data confirming the pharmaceutical or nutraceutical homogeneous mixture structure to your attention in this application. Considering all these presented data and the state of the art, it is seen that the pharmaceutical or nutraceutical homogeneous mixtures appropriate for the invention are a new mixture that has not been disclosed before in the state of the art. It is shown that the mixture appropriate for the present invention is new and has an inventive step by surpassing the state of the art.
The protection of the invention is specified in the attached claims and cannot be limited to what is described in this detailed description for exemplification purposes. Because it is clear that a person skilled in the art can present similar embodiments in the light of what has been explained above without digressing from the main theme of the invention.

Claims

9 CLAIMS
1. The invention relates to an immune-enhancer and anti-ageing homogeneous nutraceutical or pharmaceutical composition, characterized in that; the said homogeneous composition contains completely herbal-based hot pepper, black mulberry, anise, stinging nettle, fig, olive, semen pegani, mistletoe and poppy components.
2. A homogeneous pharmaceutical or nutraceutical composition according to Claim 1 , characterized in that; the homogenous composition contains hot pepper component at a value between 1% to 15% by weight; black mulberry component at a value between 1% to 15% by weight; anise component at a value between 1% to 15% by weight; stinging nettle component at a value between 1% to 15% by weight; fig component at a value between 1% to 15% by weight; olive component at a value between 1% to 15% by weight; semen pegani at a value between 1% to 15% by weight; mistletoe at a value between 1% to 15% by weight; poppy seed at a value between 1% to 15% by weight.
3. A homogeneous pharmaceutical or nutraceutical composition according to Claim 1 , characterized in that; the homogenous composition contains the hemp oil component as a solvent in certain percentages by weight.
4. A homogeneous pharmaceutical or nutraceutical composition according to Claim 2 or 3, characterized in that; the homogeneous composition/hemp oil percentage by weight is 1 :2 to 1 :4.
5. A homogeneous pharmaceutical or nutraceutical composition according to Claim 1 , characterized in that; it additionally contains one or more various auxiliary products.
6. A homogeneous pharmaceutical or nutraceutical composition according to Claim 1 , characterized in that; it contains additionally at least one other active ingredient with anti-ageing feature.
7. A homogeneous pharmaceutical or nutraceutical composition according to Claim 1 , characterized in that; it can be formulated in solid or liquid dosage forms.
8. A homogeneous pharmaceutical or nutraceutical composition according to Claim 1 , characterized in that; it can be formulated in dosage forms suitable for intake by injection. A homogeneous pharmaceutical or nutraceutical composition according to Claim 8, characterized in that; if it is formulated in dosage forms suitable for intake by injection, said dosage form can be formulated in one of the dosage forms suitable for intradermal, intramuscular, intravenous, abdominal administration.
PCT/TR2021/050798 2020-08-18 2021-08-12 An immune-enhancer and anti-ageing nutraceutical or pharmaceutical composition WO2022039700A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
TR2020/13009 2020-08-18
TR202013009 2020-08-18

Publications (1)

Publication Number Publication Date
WO2022039700A1 true WO2022039700A1 (en) 2022-02-24

Family

ID=80323654

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/TR2021/050798 WO2022039700A1 (en) 2020-08-18 2021-08-12 An immune-enhancer and anti-ageing nutraceutical or pharmaceutical composition

Country Status (1)

Country Link
WO (1) WO2022039700A1 (en)

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
AKBAY, P. ET AL.: "In vitro immunomodulatory activity of flavonoid glycosides from Urtica dioica L", PHYTOTHERAPY RESEARCH : AN INTERNATIONAL JOURNAL DEVOTED TO PHARMACOLOGICAL AND TOXICOLOGICAL EVALUATION OF NATURAL PRODUCT DERIVATIVES, vol. 17, no. 1, 2003, pages 34 - 37, XP055009371, DOI: 10.1002/ptr.1068 *
AL-SNAFI, A. E.: "Nutritional and pharmacological importance of Ficus carica-A review", IOSR JOURNAL OF PHARMACY, vol. 7, no. 3, 2017, pages 33 - 48, XP055860883, DOI: 10.9790/3013-0703013348 *
ICHIHASHI MASAMITSU, HIROKI YANAGI, SATOSHI YOSHIMOTO, HIDEYA ANDO, MAKOTO KUNISADA, CHIKAKO NISHIGORI: "Olive oil and skin anti-aging", GLYCATIVE STRESS RESEARCH, SOCIETY FOR GLYCATIVE STRESS RESEARCH, 1 January 2018 (2018-01-01), pages 86 - 94, XP055909036, Retrieved from the Internet <URL:https://www.toukastress.jp/webj/article/2018/GS18-14.pdf> [retrieved on 20220405], DOI: 10.24659/gsr.5.2_86 *
LIM SUNG, CHOI CHANG-IK: "Pharmacological Properties of Morus nigra L. (Black Mulberry) as A Promising Nutraceutical Resource", NUTRIENTS, vol. 11, no. 2, 1 January 2019 (2019-01-01), XP055909028, DOI: 10.3390/nu11020437 *
SHAHRAJABIAN MOHAMAD HESAM, SUN WENLI, CHENG QI: "Chinese star anise and anise, magic herbs in traditional Chinese medicine and modern pharmaceutical science", ASIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH, vol. 5, no. 3, 1 January 2019 (2019-01-01), pages 162 - 179, XP055909032, ISSN: 2411-4472, DOI: 10.3329/ajmbr.v5i3.43584 *
SIM, K. H. ET AL.: "The antimutagenic and antioxidant effects of red pepper seed and red pepper pericarp (Capsicum annuum L.", PREVENTIVE NUTRITION AND FOOD SCIENCE, vol. 12, no. 4, 2007, pages 273 - 278, XP053005285, DOI: 10.3746/jfn.2007.12.4.273 *

Similar Documents

Publication Publication Date Title
DE60207877T2 (en) Composition containing procyanidins for reducing appetite in mammals
EP1414469A2 (en) Formulation containing (lyso-) phosphatidylserine for the prevention and treatment of stress states in warm-blooded animals
US8092845B2 (en) Anti-inflammatory extract and agent and method for the production thereof
US11564963B2 (en) Topical compositions, process of large-scale manufacture, and method of use
US20110189319A1 (en) Lifeforce liquid supplement
Nosirova Medicinal properties of olives
US6964786B1 (en) Oil from Momordica charantia L., its method of preparation and uses
DE202008006708U1 (en) Combination of tocotrienols with long-chain fatty acids for health maintenance, pain relief and anti-inflammatory
EP3461479A1 (en) Nutraceutical and pharmaceutical compositions, and uses thereof for preserving cognitive functions
RU2314120C1 (en) Curative-cosmetic composition for external using for normalization of thyroid tissue structure
EP0273407B1 (en) Medicine for improving the specific properties of blood
EP4153321A1 (en) Topical compositions, process of large-scale manufacture, and method of use
DE102005020467A1 (en) Agent for the therapy and prophylaxis of skin diseases
Deka et al. Mechanism of action of wound healing activity of Calendula officinalis: a comprehensive review
WO2022039700A1 (en) An immune-enhancer and anti-ageing nutraceutical or pharmaceutical composition
DE60124516T2 (en) COMBINATION OF THE LEZITHINE WITH ASCORBIC ACID
DE102005062417A1 (en) Hormonal composition, useful in the preparation of agent e.g. against hormone problems and hormone disorder, comprises hormone and prehormone, a ginkgoloid active against alkyl-acyl-glycerophosphocholine, a mineral and a trace element
DE202009006461U1 (en) Combination of tocotrienols with unsaturated fatty acids as a means of protecting the heart / circulatory system, against cancers, for inhibiting inflammation, for increasing mental performance and against age-related disorders
Iqbal et al. 8. Comparative effects of sesame oil and clove oil on growth performance, blood profile and immunity of rabbit (Oryctolagus cuniculus)
Kacemi et al. Bee Pollen as a Source of Pharmaceuticals: Where Are We Now?
RU2525763C1 (en) &#34;apiferrum&#34; biological active food additive
Shrivastava et al. Biochemical studies of weed plants used as leafy vegetables by tribes and people of Chhattisgarh with special reference to the secondary metabolites confer nutraceutical properties
LU500687B1 (en) NUTRITIONAL OR DIETICAL COMPOSITION
RU2448683C1 (en) Milk-wax walnut and buckeye ointment
DE102022134337A1 (en) Composition for activating and/or stimulating the limbic system, capsule or tablet containing the same and their use as a food supplement or medicinal product

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 21858731

Country of ref document: EP

Kind code of ref document: A1

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 21858731

Country of ref document: EP

Kind code of ref document: A1