DE202009006461U1 - Combination of tocotrienols with unsaturated fatty acids as a means of protecting the heart / circulatory system, against cancers, for inhibiting inflammation, for increasing mental performance and against age-related disorders - Google Patents

Abstract

Means consisting of a mixture of tocotrienols with alpha-linolenic acid (LNA, 18: 3, omega-3) or of oils containing them for the purpose of prevention, prevention or alleviation of cardiovascular diseases, cancers, inflammatory diseases or disorders or for improved mental or sexual performance, or for age-related ailments, or to support medical treatments thereof.

Description

• Patent specification for obtaining a utility model under Reference to the priority date of patent application 10 2007 046 202.8

These Patent describes a product with the property of production from "evil" (Series 2, inflammatory, inhibiting arachidonic acid derived) eicosanoids, while at the same time the "good" (series-1 and Series 3, anti-inflammatory) eicosanoids promoted become. Moreover, by going beyond To expect health benefits from the components used, especially by the contained antioxidants.

Technical background

• a) die Neigung des Blutes sich eher zu verklumpen (Pfropfenbildung) oder zu verflüssigen
• b) die Neigung verschiedener Gewebe entweder zu Entzündungen oder zu Heilung

Eicosaniode and its subgroup prostaglandins control important parameters of health maintenance in humans as well as in animals, above all

• a) The tendency of the blood to clump up (plug formation) or liquefy
• b) the propensity of various tissues to either inflammation or healing

• 1. als Substrate aus denen im Körper mit hilfe der Enzyme Elongase, Delta-6-Desaturase (d6d) und Delta-5-Desaturase (d5d) die funktionalen hochungesättigten Fettsäuren Dihomo-Gamma-Linolensäure (DGLA), Arachidonsäure (AA), Eicosapentaensäure (EPA) und Docosahexaensäure (DHA) herstellt. Diese wiederum stellen Substrate zur Herstellung verschiedener Gruppen von Eicosanoiden dar.
• 2. direkt als Bausteine zum Einbau in die Zellmembranen, wobei das Verhältnis von ungesättigten zu gesättigten Fettsäuren in der Nahrung sich in der Zusammensetzung der Zellmembranen wiederspiegelt. Ein hoher Anteil der mehrfach ungesättigten Fettsäuren in den Zellmembranen wiederum dient deren Flexibilität (Beweglichkeit) sowie der Durchlässigkeit für Nährstoffe und Botenstoffe.
• 3. als bevorzugter Brennstoff (vor Zuckern/Glucose und gesättigten Fettsäuren)

Polyunsaturated fatty acids (PUFA), in particular the essential alpha-linolenic acid (LNA, 18: 3, omega-3) and linoleic acid (LA, 18: 2, omega-6) are used here

• 1. as substrates from which in the body with the help of the enzymes elongase, delta-6-desaturase (d6d) and delta-5-desaturase (d5d) the functional highly unsaturated fatty acids dihomo-gamma-linolenic acid (DGLA), arachidonic acid (AA), eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). These in turn represent substrates for the preparation of various groups of eicosanoids.
• 2. directly as building blocks for incorporation into cell membranes, where the ratio of unsaturated to saturated fatty acids in food is reflected in the composition of cell membranes. A high proportion of polyunsaturated fatty acids in the cell membranes in turn serves their flexibility (mobility) and the permeability to nutrients and messengers.
• 3. as a preferred fuel (before sugars / glucose and saturated fatty acids)

• I. die Hemmung der entzündungsfördernden Eicosanoide sowie anderer entzündungsfördernder Parameter
• II. Hemmung und Tod (Apoptose) von menschlichen Krebszellen
• III. das Abfangen von mutagenen Oxidantien (freie Radikale) insbesondere an Zellmembranen
• IV. die Senkung des Cholesterinspiegels
• V. die Minderung oder sogar Rückbildung der Oxidation von Plaques

Tocotrienols, T3 for short, are called natural highly unsaturated analogues of the vitamin E substance group. According to the current state of research, tocotrienols cause in the body

• I. the inhibition of proinflammatory eicosanoids as well as other pro-inflammatory parameters
• II. Inhibition and death (apoptosis) of human cancer cells
• III. the capture of mutagenic oxidants (free radicals) especially on cell membranes
• IV. Lowering of cholesterol level
• V. the reduction or even regression of the oxidation of plaques

The mentioned properties of these substances support each other mutually effective against cardiovascular diseases, Cancers and inflammatory processes.

By Combination of the substances mentioned can be a means of health promotion be achieved as a means of preventing the said Illnesses can be marketed (wellness / food supplement) or, if appropriate clinical mass studies are presented as medicinal products can be expanded. This is achieved by the present invention described.

State of the art

• zu I.: Wu SJ, et al.: Tocotrienol-rich fraction of palm oil exhibits anti-inflammatory property by suppressing the expression of inflammatory mediators in human monocytic cells. Mol Nutr Food Res. 2008 Aug; 52 (8): 921–929; PMID 18481320 .
• zu II.: Vitamin E and Breast Cancer J Nutr. 2004 Dec; 134 (12 Suppl): 3458S–3462S.; PMID 15570054 . und Guthrie N, Gapor A, Chambers AF, Carroll KK: Inhibition of Proliferation of Estrogen Receptor-Negative MDA-MB-435 and -Positive MCF-7 Human Breast Cancer Cells by Palm Oil Tocotrienols and Tamoxifen, Alone and in Combination 1997 Mar; 127 (3): 544S–548S; PMID 9082043 .
• zu III.: Packer L, Weber SU, Rimbach G.: Molecular aspects of alpha-tocotrienol antioxidant action and cell signalling. J Nutr. 2001 Feb; 131 (2): 369S–373S. C PMID 11160563 .
• zu IV.: Lowering of serum cholesterol in hypercholesterolemic humans by tocotrienols (palmvitee); PMID 2012010 .
• zu V.: „Antioxidant effects of tocotrienols in patients with hyperlipidemia and carotid stenosis”. PMID 8614310 (mit PMID wird die Nummer der Forschungsarbeit im „Pubmed” Dienst referenziert)

As an example, I refer to the following research work on the state of the art and the substantiation of the issues mentioned under "technical background":

• to I .: Wu SJ, et al .: Tocotrienol-rich fraction of palm oil exhibits anti-inflammatory property by suppressing the expression of inflammatory mediators in human monocytic cells. Mol Nutr Food Res. 2008 Aug; 52 (8): 921-929; PMID 18481320 ,
• to II .: Vitamin E and Breast Cancer J Nutr. 2004 Dec; 134 (12 Suppl): 3458S-3462S .; PMID 15570054 , and Guthrie N, Gapor A, Chambers AF, Carroll KK: Inhibition of Proliferation of Estrogen Receptor Negative MDA-MB-435 and Positive MCF-7 Human Breast Cancer Cells by Palm Oil Tocotrienols and Tamoxifen, Alone and in Combination 1997 Mar; 127 (3): 544S-548S; PMID 9082043 ,
• to III .: Packer L, Weber SU, Rimbach G .: Molecular aspects of alpha-tocotrienol antioxidant action and cell signaling. J Nutr. 2001 Feb; 131 (2): 369S-373S. C PMID 11160563 ,
• to IV .: Lowering of serum cholesterol in hypercholesterolemic humans by tocotrienols (palmvitee); PMID 2012010 ,
• to V .: "Antioxidant effects of tocotrienols in patients with hyperlipidemia and carotid stenosis". PMID 8614310 (with PMID the number of the research work is referenced in the "Pubmed" service)

The Points a), b) and 1 to 3 are widely used in the literature Find.

Through the work of Dr. Johanna Budwig and the Nobel laureate for medicine Otto Heinrich Warburg have set up a cancer-inhibiting nutrition plan, which is supported by the points a), b) and 1 to 3 is supported.

• Tim J. Schulz, René Thierbach, Anja Voigt, Gunnar Drewes, Brun Mietzner, Pablo Steinberg, Andreas F. H. Pfeiffer und Michael Ristow: „Induction of Oxidative Metabolism by Mitochondrial Frataxin Inhibits Cancer Growth: Otto Warburg Revisited”, Journal of Biological Chemistry, Vol. 281, Nr. 2, 13. 01. 2006, S. 977–981 .

The hypothesis of Dr. med. Warburg was confirmed in 2006, among other things by the following research:

• Tim J. Schulz, René Thierbach, Anja Voigt, Gunnar Drewes, Brun Mietzner, Pablo Steinberg, Andreas FH Pfeiffer and Michael Ristow: "Induction of Oxidative Metabolism by Mitochondrial Frataxin Inhibits Cancer Growth: Otto Warburg Revisited", Journal of Biological Chemistry, Vol 281, No. 2, 13. 01. 2006, pp. 977-981 ,

The anti-inflammatory properties of omega-3 fatty acids are becoming increasingly inflammatory by many stakeholders Diseases (such as rheumatism, asthma) are valued and applied.

The in linseed, the main source of alpha-linolenic acid, also occurring phytochemicals lignans are known as anti-cancer agents.

polyunsaturated Fatty acids are subject to the strong risk of oxidation (Ranzigwerdung), both during storage and within Cell membranes. Protection against this danger offer fat-soluble Antioxidants, especially all types of vitamin E (tocopherols and Tocotrienols).

operation

• 1. Tocotrienolen
• 2. der (omega-3) Fettsäure Alpha-Linolensäure (LNA) optional unterstützt durch Gamma-Linolensäure, Linolsäure und Ölsäure
• 3. sekundären Pflanzenstoffen aus den Pflanzenölen (soweit vorhanden), nämlich der Lignane, des Sesamins und weiterer noch nicht beschriebener Stoffe in den Presskuchen von Leinsamen, Sesamsamen und Hanfsamen

The present invention is based on the cooperative and mutually reinforcing (synergistic) effect of

• 1. tocotrienols
• 2. The (omega-3) fatty acid alpha-linolenic acid (LNA) optionally supported by gamma-linolenic acid, linoleic acid and oleic acid
• 3. phytochemicals derived from vegetable oils (if present), namely lignans, sesamin and other undescribed substances in the presscake of linseeds, sesame seeds and hemp seed

• 1. durch Schutz der Fettsäuren vor Oxidation
• 2. durch deren eigene Wirksamkeit in den angestrebten Einsatzgebieten Herz/Kreislauf, Krebs, Entzündungshemmung und Gehirnleistung

The tocotrienols support the described agent

• 1. by protecting the fatty acids from oxidation
• 2. by their own effectiveness in the desired areas of application cardiovascular, cancer, anti-inflammatory and brain performance

Discussion of the substances

1. Tocotrienols

The Fat-soluble vitamin E occurs in nature in eight forms on, namely alpha-, beta-, gamma-, and delta-tocopherol, and alpha-, beta-, gamma-, and delta-tocotrienol. In the nature are tocotrienols in red palm oil, in rice oil and contained in coconut oil to a significant extent.

tocotrienols for the purposes of this invention are natural alpha-tocotrienol, Beta tocotrienol, gamma tocotrienol, delta tocotrienol or their chemical Modifications or synthetic molecules consisting of the Chromanol group as in natural tocopherols and Tocotrienols can be found with a variation of the side chain.

Across from commonly used in (eg in cosmetics) tocopherols Tocotrienols have a polyunsaturated side chain on. Presumably, tocotrienols can do a lot better penetrate into tissue and cell membranes to develop their effect there.

In Research at the cell membrane was 40-60-fold higher Antioxidant effect of tocotrienols compared to tocopherols detected. This extraordinary antioxidant effect can the inflammation and inflammation neutralize reinforcing free radicals. About that In addition to tocotrienols act directly on the genesis of the mentioned "unwanted" eicosanoids as well as the genesis of cholesterol. In addition, act Tocotrienols have a positive effect on tumor cells. Furthermore Research has many other health benefits Tocotrienols detected.

2. Omega-3 fatty acids

The Omega-3 fatty acid LNA is predominant as a natural product in linseed oil, to a lesser extent also in camelina oil, Walnut oil, hemp oil, rapeseed oil and others contain.

When most important property reduces their property the genesis of Arachidonic acid and thus the emergence of unwanted Series 2 eicosanoids due to competition for the enzyme delta-5-desaturase, but also d6d, as well as Elongase.

LNA, which is incorporated in cell membranes, causes their improved flexibility, as well as permeability to nutrients and messengers. The improved flexibility should be the Blood flow through the finest blood vessels (capillaries) promote. The improved permeability promotes the energy status of the cells, which exactly corresponds to the claim of the Warburg hypothesis.

3. Other fatty acids (LA, GLA, DGLA and OA)

LA, GLA and DLGA are precursors to the genesis of the desired Series 1 Eicosanoids.

Indeed is the dihomogammalinolenic acid (DLGA) in the body converted into the dreaded arachidonic acid by only one enzyme step (D5D).

Out For this reason, the amount of these fatty acids, more precisely said the ratio of these to omega-3 linolenic acid be limited. For the long-term diet Healthy is a ratio of 4: 1 (omega-6 to omega-3) described as desirable. As the one described here Means to compensate for a disproportion, the has already been developed over many years (installation in storage grease and cell membranes), should have a maximum ratio of 50% Omega-6 Fatty acids (better a ratio of 1: 4) sought become.

The oleic acid (OA) is present in only a few oils as a significant proportion (Olive oil).

The oleic acid acts weakly supportive in the sense of this invention, because it also competes for the enzyme D5D and also membranes a little more flexible than saturated fat power.

The mentioned properties explain the so-called Mediterranean syndrome, the finding that in the Mediterranean countries with high Consumption of olive oil significantly fewer cardiovascular diseases prevail.

4. Lignans

So are called phytochemicals that are found in flaxseed and thus in the linseed oil as well as in the linseed press cake are.

she It is known to act on hormone receptors in various organs protecting prostate, skin and other organs from cancer.

Dosage of ingredients

1. Dosage of tocotrienols

The amounts used in scientific studies on tocotrienols are in the range of 80 to 120 mg tocotrienol per day in oral Administration.

The Tocotrienols are said to be dosed in the present invention, that during normal use of the drug daily doses arise, the between 10 and 400 mg.

at the expression as cold used kitchen oil (for salads and special preparations) can be used Amount of five to 25 grams are assumed.

This gives a percentage of 0.2% at 5 g (1 tsp) and 10 mg t3
and at 25 g and 400 mg T3 a maximum percentage of 1.6% tocotrienol.

in the Case of the so-called Budwig cream, consisting of 125 g quark and 25 g oil would result in striving the 100 mg / day a share of 0.4 percent.

2. Dosage of omega-3 and omega-6 fatty acids

she should be the main component of the agent described as a share the PUFA, preferably ranging from 75% LNA to 25% omega-6 fatty acids.

This is given by natural flax seed oil.

3. Dosage of omega-9 fatty acids (OA)

By Mixture with oleic acid may be the active ingredient of PUFA without negative impact and with low positive impact by the OA are optionally lowered.

The PUFA should not fall below the amount of 20% PUFA.

This would correspond to a proportion when using olive oil of about 80% olive oil.

The Use of oleic acid can be zero, or the present in the natural oils low levels be set.

4. Dosage of phytochemicals (eg Lingnane and Sesamin)

Especially when expressed as cancer precautionary should the course present in linseed oil, sesame oil and their seeds Lignans and sesamin used according to their natural concentrations become.

This ranges from quite low concentrations when using natural oils (can also be zero) up to the maximum dosage by use of press cake or whole seeds.

Side effects, toxicity and maximum doses

1. Tocotrienols

at Tocotrienols is a fat-soluble vitamin.

It However, it can also be excreted via the liver and kidneys.

• – eine Menge von 12–14 mg Vitamin E entspricht der empfohlenen Tagesaufnahme
• – eie Europäische Behörde für Lebensmittelsicherheit (EFSA) definiert als tolerierbare Höchstaufnahmemenge (die Menge, die ein gesunder Erwachsener lebenslang täglich verzehren kann, ohne dass gesundheitliche Risiken zu befürchten sind) die Aufnahme von 300 mg täglich
• – nach Angabe von Herstellern von Vitamin E Präparaten treten bei Dosierung von 1200 mg alpha-Tocopherolacetat ”sehr selten” (1 oder weniger aus 10000 Behandelten), oral eingenommen, Magen und Darm-Beschwerden auf.

For vitamin E, there are approximately the following dosage guidelines:

• - An amount of 12-14 mg of vitamin E corresponds to the recommended daily intake
• - The European Food Safety Authority (EFSA) defines a maximum tolerable intake (the amount that a healthy adult can consume lifelong daily without any risk to health) of 300 mg per day
• - According to manufacturers of vitamin E preparations occur at a dosage of 1200 mg alpha-tocopherol "very rarely" (1 or less from 10000 treated people), taken orally, stomach and intestinal complaints.

There a study with alpha tocopherol the use of vitamin E only up to the maximum limit of 400 mg / day should be recommended all daily portions maximum doses of 400 mg / day also for Go for tocotrienols.

2. fats

All These fatty acids are found in nature, in foods (Vegetable oils, animal fat) and in the body in large Quantities. They are used both for energy production, as well as for Formation of structures needed.

From the DGE (German Nutrition Society) and other organizations are issued recommendations that the restriction of fats on energy production about 40% want to see limited. I point that out The purpose of these recommendations is rather to reduce unfavorable (usually animal) fats. Actually there it's just some tissues (like the brain) that are exclusive to carbohydrates are reliant. As far as predominantly positive oils used is an energy supply through oils up to about 500 kcal per day from carbohydrates possible, possibly desirable. In the sense of work by Nobel laureate Warburg is an elevated one Proportion of lipids in the diet desirable.

As is known, can over-supply with omega-3 oils and with Vitamin E increases the tendency to bleeding. At a very A small proportion of the population must be made aware of this danger. The majority of the population would be just this larger fluid of the blood one aspired Impact.

In summary It can be said that all components of the invention described can be considered highly harmless.

Suggestions for application forms the invention

1. Church oil off Linseed oil with tocotrienol

• – Krebs-Schutz wie er durch viele wissenschaftliche Studien nahegelegt wird
• – Cholesterin-Senkung, Plaquen-Regression und Durchblutungssteigerung
• – Schutz vor Neurodegeneration und verbesserte Durchblutung für geistige Leistungsfähigkeit
• – die entzündungshemmenden Eigenschaften

Probably the most important feature of the invention would be the provision of a high quality linseed oil with a tocotrienol content of 0.4 to 2 percent. Users who want to use linseed oil for health reasons can thus benefit from the additional health benefits of the synergistic interaction of linseed oil with tocotrienols.

• - Cancer protection as suggested by many scientific studies
• - Cholesterol reduction, plaque regression and blood circulation increase
• - Protection against neurodegeneration and improved blood flow for mental performance
• - the anti-inflammatory properties

There the alpha-linolenic acid present in linseed oil especially prone to spoilage by oxidation is Oxidation protection by antioxidants important. This one will be in ideally by the very good antioxidant in the form of tocotrienols (Part of the vitamin E family). This is coming the shelf life of the product. Likewise, submit studies close, that also within the body when enjoying larger Amounts of polyunsaturated fatty acids increased protection ensured by sufficient vitamin E have to be.

tocotrienols are also available as an extract from natural red palm oil to disposal. In this way, the vitamin-rich admixture be declared as natural oil admixture and does not have to be considered an added vitamin b.

2. kitchen oil in reduced concentration

The Kitchen oil from the above composition is ideal, if a high need for obtaining health Benefits (eg cancer protection). After a transition period of about two years (renewal of many cell membranes and parts of the store fat) could exist the desire to share to reinforce conventional oils.

In this case, I suggest the addition of omega-6 oils, omega-9 oils or saturated oils of up to 80%. In the case of omega-6 oils (eg sunflower oil, sesame oil, wheat germ oil, almond oil) or weaker omega-3 oils (walnut oil, hemp oil, rapeseed oil) care must be taken that the ratio of omega-6 to omega-3 fatty acids never falls below the number four. When using saturated fats or oils (eg coconut oil) and omega-9 oils (olive oil), it should be noted that the proportion of polyunsaturated saturated fatty acids must not fall below about 17%.

3. Nutmeg with tocotrienol protection

To the teachings of dr. Budwig is the combination of alpha-linolenic acid especially valuable with sulphurous amino acids. For this the use of skimmed quark with linseed oil is recommended. By Use of the above-described linseed oil / T3 mixture instead pure linseed oil can provide the health benefits mentioned added or reinforced by tocotrienols become.

When In addition to quark, walnut or press cake are also suitable as a source of information of oilseeds, which are also high in content to the required sulfur-containing amino acids (cysteine and methionine).

• – gute Haltbarkeit (besser als Quark) durch hohen Lipid-Gehalt und den Vitamin-E Schutz
• – Erreichung eines angemessenen Verhältnisses von omega-3 zu omega-6 Fettsäuren der sonst bei Ölsaaten überwiegend ungünstig ausfällt
• – zusätzliche Aufwertung durch reichlich in den Samen vorhandenen B-Vitamine und Mineralien (insbesondere Zink). Dies ist besonders für die Anwendung zu Steigerung der geistigen Leistungsfähigkeit wünschenswert.
• – zusätzliche Aufwertung durch die sekundären Pflanzenstoffe (z. B. Sesamin, Lignane) die in den Saaten selbst noch wesentlich reicher enthalten sind als in deren Ölen.

I suggest the use of pumpkin seeds, sesame, almonds, hemp seeds or other oil fruits. The resulting nutmeg or presscake bars are characterized by the following advantages:

• - good shelf life (better than cottage cheese) due to high lipid content and vitamin E protection
• Achieving an appropriate ratio of omega-3 to omega-6 fatty acids, which is otherwise unfavorable for oilseeds
• - additional enhancement by abundant B vitamins and minerals present in the seeds (especially zinc). This is especially desirable for use in enhancing mental performance.
• - additional revaluation by the secondary plant substances (eg sesamin, lignans) which are still much richer in the seeds themselves than in their oils.

4. Means to increase mental Efficiency or against "Alzheimer's"

As has been proven by research, protect tocotrienols before neurodegeneration. In addition, by tocotrienols as by omega-3 fatty acids increase the blood flow (also) of the brain improves as well as normalizes blood pressure. This sets the deployment a means to increase mental performance Near. By using the above-described combination with oilseeds, or parts thereof (eg press cake) are additional important vitamins of B-complex and trace elements for Nerve cells available.

For a means of staging mental capacity we propose the additional use of the long-chain Fatty acids EPA (eicosapentaenoic acid) and / or DHA (Docosahexaenic acid) before, preferably in non-admixed Shape, about as a capsule.

5. Means to improve the sexual Potency and urological problems (eg prostate problems)

By Use of oilseeds according to proposed use 3, in particular By pumpkin seeds, the body can increase zinc and other trace elements are supplied. Zinc in turn especially in older people often limits production of sex hormones. By interacting with the improved Blood circulation and by the positive effect on the prostaglandins by tocotrienols and omega-3 fatty acids offers the Providing a sexual enhancer at. Research into tocotrienols also has positive effects of tocotrienols on testosterone production.

Also urological problems, especially prostate problems This combination promises relief or cure.

6. Dental care products

As described are tocotrienols as well as omega-3 fatty acids anti-inflammatory. This property is for Dental care advantageous, especially for the gums.

The greasy components (eg linseed oil) serve to improve Solution of lipophilic deposits on gums and teeth, also from bacteria.

to Obtaining a dentifrice must be the means according to proposal 1, or a stronger concentration of this, into a gel-like or paste-like substance.

QUOTES INCLUDE IN THE DESCRIPTION

This list The documents listed by the applicant have been automated generated and is solely for better information recorded by the reader. The list is not part of the German Patent or utility model application. The DPMA takes over no liability for any errors or omissions.

Cited non-patent literature

• - Wu SJ, et al .: Tocotrienol-rich fraction of palm oil exhibits anti-inflammatory property by suppressing the expression of inflammatory mediators in human monocytic cells. Mol Nutr Food Res. 2008 Aug; 52 (8): 921-929; PMID 18481320 [0007]
• - Vitamin E and Breast Cancer J Nutr. 2004 Dec; 134 (12 Suppl): 3458S-3462S .; PMID 15570054 [0007]
• - Guthrie N, Gapor A, Chambers AF, Carroll KK: Inhibition of Estrogen Receptor Negative MDA-MB-435 and -Positive MCF-7 Human Breast Cancer Cells by Palm Oil Tocotrienols and Tamoxifen, Alone and in Combination 1997 Mar; 127 (3): 544S-548S; PMID 9082043 [0007]
• - Packer L, Weber SU, Rimbach G .: Molecular aspects of alpha-tocotrienol antioxidant action and cell signaling. J Nutr. 2001 Feb; 131 (2): 369S-373S. C PMID 11160563 [0007]
• - Lowering of serum cholesterol in hypercholesterolemic humans by tocotrienols (palmvitee); PMID 2012010 [0007]
• - "Antioxidant effects of tocotrienols in patients with hyperlipidemia and carotid stenosis". PMID 8614310 [0007]
• - Tim J. Schulz, René Thierbach, Anja Voigt, Gunnar Drewes, Brun Mietzner, Pablo Steinberg, Andreas FH Pfeiffer and Michael Ristow: "Induction of Oxidative Metabolism by Mitochondrial Frataxin Inhibits Cancer Growth: Otto Warburg Revisited", Journal of Biological Chemistry, Vol. 281, No. 2, 13, 01. 2006, pp. 977-981 [0010]

Claims (10)

Agent consisting of a mixture of tocotrienols with alpha-linolenic acid (LNA, 18: 3, omega-3) or from oils which contain these for the purpose of prevention, contraception or Relief of cardiovascular diseases, of cancers, of inflammatory diseases or discomfort or for improved mental or sexual performance or against age complaints, or to support medical Treatments of the same. Expression of the agent according to claim 1 with a Proportion of 0.06 to 5.0 percent tocotrienol. Expression of the agent according to claim 1 and 2 with a content of at least 20% polyunsaturated Fatty acids. Expression of the agent according to claim 1 to 3 with the ratio of alpha-linolenic acid at least exceeds the proportion of omega-6 fatty acids. Expression of the agent according to one of the preceding Claims, consisting of a tocotrienol-rich extract from natural red palm oil or rice oil (TRF) in an oil mixture consisting of 5% to 100% linseed oil together with possible proportions of olive oil, Borage oil, evening primrose oil, wheat germ oil or sesame oil. Expression of the agent according to one of the preceding Claims as greasy or oily substance for oral use in the form of kitchen oil, capsules, Spreads or the like. Expression of the agent according to one of the preceding Claims by mixing with quark ("tocotrienol Budwig cream") or with another egg-containing substrate. Expression of the agent according to one of the preceding Claims 1 to 6 by mixing with a mus ("nutmeg") or presscake of flaxseed, sesame seeds, hemp seeds, almonds or with another oilseed or oilseed. Expression of the agent according to one of the preceding Claims 1 to 5 as dentifrice by adding a any gel or pasty substrate with Abrasives. Expression of the agent according to one of the preceding Claims 1 to 8 as a means for increasing mental performance, especially in the form of a "bar".