WO2022015133A1 - Mousse antiseptique de protection cutanée - Google Patents

Mousse antiseptique de protection cutanée Download PDF

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Publication number
WO2022015133A1
WO2022015133A1 PCT/MX2020/000025 MX2020000025W WO2022015133A1 WO 2022015133 A1 WO2022015133 A1 WO 2022015133A1 MX 2020000025 W MX2020000025 W MX 2020000025W WO 2022015133 A1 WO2022015133 A1 WO 2022015133A1
Authority
WO
WIPO (PCT)
Prior art keywords
composition
skin
antiseptic
foam
water
Prior art date
Application number
PCT/MX2020/000025
Other languages
English (en)
Spanish (es)
Inventor
Tzintzun CARRANZA LÓPEZ
Original Assignee
Carranza Lopez Tzintzun
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Carranza Lopez Tzintzun filed Critical Carranza Lopez Tzintzun
Publication of WO2022015133A1 publication Critical patent/WO2022015133A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/14—Quaternary ammonium compounds, e.g. edrophonium, choline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/02—Local antiseptics

Definitions

  • the present invention is directed to the field of broad-spectrum dermal disinfectants for local application. Particularly to aqueous solutions in the form of foam that produce a protective film, which prevents microbial contamination from bacteria, fungi and viruses, as well as protection against different types of chemicals.
  • Antibacterial gels, antiseptics or hand sanitizers make our lives easier in this hygiene-obsessed age. They are seen everywhere: in public bathrooms, in hospitals, in gyms, at the entrance and exit of places with a lot of human traffic, installed in easy-to-operate dispensers. In addition, they are easy to carry in your pocket in small plastic bottles. Just a few drops and that's it, hands are considered clean and disinfected.
  • US Centers for Disease Control and Prevention indicates that hand sanitizers and antibacterial gels are not as effective against some types of.
  • Antibacterial gels don't work very well, such as when hands are very oily or dirty. These conditions can occur when camping, playing sports or gardening. Antibacterial products are also not very good at removing harmful chemicals from your hands, such as pesticides and heavy metals.
  • Hand gels do not protect against salmonella, e. coli, antibiotic-resistant Staphylococcus aureus (MRSA), and norovirus, which can cause serious complications, including death. These four diseases can be spread from person to person. In the case of the mullet and the e. coli, cause diarrhea that can be fatal in severe cases. The contagion can happen through contact with feces or with food that has not been properly refrigerated.
  • MRSA antibiotic-resistant Staphylococcus aureus
  • Norovirus is a common disease that is often contracted on cruise ships and is easily transmitted between passengers and crew. It is the main cause of the symptoms of gastroenteritis or "intestinal flu” and antibacterial gels simply cannot kill it. In the case of the coronavirus, they can be effective, but only as a temporary measure, while you have access to soap and water.
  • Patent application MX/a/2017/005243; BIODEGRADABLE AND ANTIBACTERIAL ORGANIC GEL FOR HANDS AND SKIN describes an organic gel for hands and skin that is biodegradable and antibacterial, characterized by being made based on carbomer, triethanolamine, glycerin and chitosan, which does not affect the environment or cause skin irritation or in the hands.
  • a composition of crystalline antibacterial gel for hands with citrus fragrance with moisturizing characteristics is provided that has main application in places where water is scarce; of daily use several times a day, and is suitable for children. This is achieved by adding natural humectants and using an antibacterial disinfectant agent, pure cane ethyl alcohol.
  • the composition consists of different compounds comprising; rheological modifier, sequestrant, fragrance, emulsifier, neutralizer, humectant, solvent and disinfectant.
  • the application PA/A/2008/014962, ANTIBACTERIAL AND ANTICORROSIVE COMPOSITION FOR THE PROTECTION OF THE SKIN provides an aqueous emulation comprising from 50% to 85.0% of water, from 0.5% to 5.0% of other ingredients such as the active ingredient, the active ingredient includes but is not limited to oil-soluble vitamins, water-soluble vitamins, active fatty acids, fatty acids, fatty alcohol esters of fatty acids, hydrocarbons, liquid and solid wax and silicone liquids of various types, the composition it can also include preservatives and fragrance oils, the compositions can also include essential oils, with a layer that applied to the skin will remain insoluble in water, this layer protects the skin when it dries, even against friction.
  • the composition can be applied to skin of different pharmaceutical forms, these application forms include but are not limited to gel, creams, lotions, sprays, ointments and aerosols.
  • An alternative solution is antiseptic foams, which are based on alcoholic antiseptic solutions. Alcoholic antiseptic solutions are used to reduce the number of viable microorganisms on the hands, reducing the risk of spreading infectious diseases.
  • These products contain antiseptic agents or antimicrobial substances, including alcohols, chlorhexidine, chlorine, hexachlorophene, iodine, chloroxylenol (PCMX), quaternary ammonium compounds, and triclosan.
  • antiseptic agents or antimicrobial substances including alcohols, chlorhexidine, chlorine, hexachlorophene, iodine, chloroxylenol (PCMX), quaternary ammonium compounds, and triclosan.
  • the effectiveness of the composition may be similar to that of the antibacterial gel, but the difference is the physical form, liquid or foam.
  • the hydro-alcoholic foam solution eliminates the above problems, even with a smaller amount of product, which means lower overall consumption.
  • the hydro-alcoholic foam solution is more effective, since the entire dose of product applied remains in the hands without spilling, its distribution is homogeneous, and less quantity is needed to achieve the same effectiveness as in liquid or in gel.
  • the object of the present invention is to provide a composition of an antiseptic solution in foam form, where the antiseptic foam that is obtained protects the skin from oils, greases, solvents, paints, alkalis, acids, drilling fluids and pathogens.
  • Said antiseptic foam is not toxic, flammable or destructive to the ozone layer.
  • it protects the foot! from contact burns with 37% hydrochloric acid and 50% sodium hydroxide; forms a biomechanical layer that adheres to the skin and prevents the absorption of chemical substances through it.
  • the antiseptic foam has a pH between 6 and 7, it is completely soluble in water; whose density at 25°C is 1g/ml; and is stable under normal conditions of storage and use for up to 24 months
  • the antiseptic foam is a disinfectant, and has a protective action on the skin against: microorganisms, oils, fats, solvents, paints, alkalis, acids, etc. Its disinfectant and protective action have an effective effect for 4 hours. It forms a biomechanical layer that adheres to the skin, preventing the absorption of chemical substances through it. It includes quaternary ammonium salts that have a disinfecting effect against bacteria, fungi and some types of viruses.
  • the foam object of the present invention prevents cross contamination for 4 hours; contains quaternary ammonium salts that have disinfectant activity on bacteria (mainly Gram positive), fungi and viruses, thus helping to prevent infections caused by these microorganisms, prevents allergic reactions caused by the latex of the gloves, avoids burns, cracking or irritation caused by contact with irritating substances.
  • the antiseptic foam is non-toxic and non-absorbable so it does not impede breathing in the pores or decrease sensitivity. It is free of dyes, fragrances, alcohol and silicone.
  • the antiseptic foam is administered and applied after washing the area where the product will be applied with soap and water, rinsing and drying completely. Antiseptic foam is applied, distributing evenly over the entire area; when applying to the hands, make sure that the foam comes into contact with the cuticle and the skin under the nails; it is allowed to air dry. This procedure can be repeated again at 4 hours.
  • composition of the antiseptic solution to obtain the antiseptic foam object of the present invention comprises alkyl dimethyl ammonium hydrochloride between 0.1 and 10% p/p, hydroxyethyl cellulose from 10 to 25% p/p, propylene glycol from 5 to 45%, PVP K-30 from 10 to 25% p/p, ethoxylated lanolin 10 to 15%, citric acid 0.1-5%, may also include other excipients or pharmaceutically acceptable additives, such as emollients, moisturizers, sunscreens, UV protectors, among others in pharmaceutically effective amounts and as solvent water.
  • composition of the antiseptic solution to obtain the antiseptic foam of the invention is prepared according to the following procedure;
  • the composition of the antiseptic solution to obtain the antiseptic foam was tested through the following clinical trials: Hand smears; irritation test; Microbial Challenges and a Verification Study for Performance carried out at the Research Center for Industrial Development of the Autonomous University of Guadalajara. a) Hand smears:
  • the antiseptic foam object of the present invention has antimicrobial effectiveness for up to a maximum of 4 hours.
  • the irritability test showed that the antiseptic foam of the invention is not irritating to human skin.
  • a statistically representative sample of individuals had antiseptic foam applied to their hands, arms, and legs. They were asked to rate the sensation of irritation on a scale from 0 to 5. The sensation of irritation was subject to visual tactile verification in the area of application of the foam.
  • the final average irritation index was 0.0, that is, the product is not irritating.
  • the results of the microbial challenges are shown below: d) The Verification Study for the performance of the antiseptic foam of the invention, demonstrated the effectiveness of protection for 4 (four) hours with a single application against products with different characteristics, such as acidic and basic pH's, easy removal of paints, fats and contact adhesives, as well as demonstrate that it avoids dryness when using organic solvents such as the so-called "thinner”.
  • the volunteers of the 8 groups washed their hands with soap and water, dried their hands, after which an amount of antiseptic foam object of the invention was applied to one hand and allowed to dry.

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Cosmetics (AREA)
  • Medicinal Preparation (AREA)

Abstract

La présente invention concerne une composition d'une solution antiseptique sous forme de mousse, la mousse antiseptique obtenue protégant la peau contre des huiles, des graisses, un solvant, des peintures, des alcalis, des acides, des fluides de perforation et des agents pathogènes. Ladite mousse antiseptique n'est pas toxique, inflammable, ou destructrice pour la couche d'ozone. En outre, elle protège la peau de brûlures par contact avec des acides et des alcalis , forme une couche biomécanique qui adhère à la peau et évite l'absorption de substances chimiques à travers celle-ci.
PCT/MX2020/000025 2020-07-13 2020-08-06 Mousse antiseptique de protection cutanée WO2022015133A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
MXMX/A/2020/005510 2020-07-13
MX2020005510A MX2020005510A (es) 2020-07-13 2020-07-13 Espuma antiseptica protectora de piel.

Publications (1)

Publication Number Publication Date
WO2022015133A1 true WO2022015133A1 (fr) 2022-01-20

Family

ID=79554950

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/MX2020/000025 WO2022015133A1 (fr) 2020-07-13 2020-08-06 Mousse antiseptique de protection cutanée

Country Status (2)

Country Link
MX (1) MX2020005510A (fr)
WO (1) WO2022015133A1 (fr)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2247555C1 (ru) * 2003-12-19 2005-03-10 Бородкина Татьяна Владимировна Гель антибактериальный
CN107536727A (zh) * 2017-08-28 2018-01-05 上海美浮特生物科技有限公司 一种免洗手皮肤抗菌泡沫及其制备方法
CN107714501A (zh) * 2017-10-24 2018-02-23 山东新华医疗器械股份有限公司 一种无醇泡沫手消毒液
CN110960432A (zh) * 2019-12-21 2020-04-07 中山市川林生物科技有限公司 一种泡沫洗手液及其制备方法

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2247555C1 (ru) * 2003-12-19 2005-03-10 Бородкина Татьяна Владимировна Гель антибактериальный
CN107536727A (zh) * 2017-08-28 2018-01-05 上海美浮特生物科技有限公司 一种免洗手皮肤抗菌泡沫及其制备方法
CN107714501A (zh) * 2017-10-24 2018-02-23 山东新华医疗器械股份有限公司 一种无醇泡沫手消毒液
CN110960432A (zh) * 2019-12-21 2020-04-07 中山市川林生物科技有限公司 一种泡沫洗手液及其制备方法

Also Published As

Publication number Publication date
MX2020005510A (es) 2022-01-14

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