WO2022004876A1 - 液体注入装置、及びそのシステムとカートリッジユニット - Google Patents

液体注入装置、及びそのシステムとカートリッジユニット Download PDF

Info

Publication number
WO2022004876A1
WO2022004876A1 PCT/JP2021/025124 JP2021025124W WO2022004876A1 WO 2022004876 A1 WO2022004876 A1 WO 2022004876A1 JP 2021025124 W JP2021025124 W JP 2021025124W WO 2022004876 A1 WO2022004876 A1 WO 2022004876A1
Authority
WO
WIPO (PCT)
Prior art keywords
injection device
liquid injection
liquid
cartridge unit
cartridge
Prior art date
Application number
PCT/JP2021/025124
Other languages
English (en)
French (fr)
Japanese (ja)
Inventor
岩男 山▲崎▼
知司 小杉
Original Assignee
ヤーマン株式会社
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ヤーマン株式会社 filed Critical ヤーマン株式会社
Priority to CN202180028185.5A priority Critical patent/CN115397502A/zh
Priority to JP2022534125A priority patent/JPWO2022004876A1/ja
Publication of WO2022004876A1 publication Critical patent/WO2022004876A1/ja

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin

Definitions

  • the present invention relates to a liquid injection device via a microneedle that injects a liquid such as a lotion or a chemical solution into the skin, and a system and a cartridge unit thereof.
  • microneedles act as devices for percutaneous absorption.
  • the skin is composed of the epidermis and dermis.
  • the epidermis is a hard protein composed of the stratum corneum and keratinocytes that block the invasion of bacteria and dust and form a barrier to prevent water evaporation from the body, and the basal layer and spinous layer that protect the skin from ultraviolet rays with melanin pigment. It is a layer.
  • the dermis is composed of fibrous collagen, jelly-like hyaluronic acid, etc., and is a highly elastic protein layer in which nerves, blood vessels, lymph vessels, etc. are stretched.
  • the amount of liquid that can be injected into the skin is extremely small compared to the amount into the subcutaneous tissue, which is 0.2 ml or less for the elastic dermis and about 1/100 of that for the epidermis, which is a hard protein.
  • the thickness of the skin is about 1.5 to 2 mm even when the epidermis and dermis are combined, so the microneedle is an effective device that can control the amount and depth of percutaneous absorption.
  • seal-type microneedles are used in the beauty field to spread needle-shaped collagen and hyaluronic acid like a pincushion and fix them with an adhesive for a long time to penetrate the areas such as the eyes and nasolabial folds where you want to repair the skin. ..
  • Patent Document 1 includes a housing, a microneedle array holder for holding a microneedle array, and a shuttle for holding a cartridge, wherein the microneedle array holder has a retracted position and an extended position. Movable configurations are disclosed between. In this configuration, only the cartridge containing the chemical solution can be replaced, and the microneedle array and the microneedle array holder arranged apart from the cartridge are moved from the retracted position to the extended position by the stored energy device.
  • the stored energy device is specifically a coil spring, which is supposed to hit the skin at a constant collision speed.
  • Patent Document 2 discloses an operating device capable of easily and surely injecting a desired amount of fluid into a skin tissue in a short time when intradermal injection is performed with a fluid injector using a multi-microneedle device.
  • This instrument is characterized by its simplicity and low cost, including the initial position where the needle of the device body is retracted into the opening, the first position where it protrudes outward from the opening to the first distance, and the second distance which is shorter than the first distance. It is provided with a mechanism for sequentially moving between the second positions protruding externally. After the fluid flows out at the second position, the injector is urged to the initial position by magnetic force. It is not possible to repeatedly inject a predetermined amount by returning to the initial position each time, and it is disclosed as a configuration in which all of the desired amount of fluid in the fluid injector is injected into the skin tissue at a desired location.
  • Patent Document 3 has a delivery assembly comprising a plurality of microneedles configured to deliver the drug percutaneously to the patient and measures at least one physical parameter determined by the volume of the drug in the device.
  • a drug delivery device comprising a sensing unit configured as described above is disclosed.
  • the present device discloses a configuration in which a capacitor is formed by providing two electrodes through which a drug flows, and the volume is measured by measuring the capacitance thereof. It also discloses a configuration for measurement by a photodetector. In this case, these measuring means are required between the microneedle and the drug accommodating portion, and there is a problem that the accommodating portion and the microneedle cannot be easily replaced, and the structure and control of the device become complicated. ..
  • the present invention was created in view of the above-mentioned problems of the prior art, and is a liquid injection device for injecting a liquid from a microneedle into the skin having low permeability, and can accurately and easily inject a small amount of liquid. It provides the technique of injecting. At the same time, it provides a technology that enables the user to inject the liquid into the epidermis in a short time without waste by operating at the timing when the device is brought into contact with the skin, and to administer the beauty essence over a wide area. The purpose is.
  • the present invention provides the following liquid injection device.
  • it is a liquid injection device that injects a liquid into the skin via a microneedle, and is composed of a cartridge unit and a main body, and the cartridge unit contains a microneedle and a liquid. It is provided with a discharge hole for discharging and a bottle portion for accommodating liquid.
  • the main body is provided with a cartridge mounting portion for mounting the cartridge unit detachably, and an acting force generating mechanism for causing a liquid discharge action on the mounted cartridge unit. This makes it possible to provide a liquid injection device that can be used while exchanging the cartridge unit.
  • a microneedle and a discharge hole can be provided at the tip portion, and the tip portion can be attached to the above bottle portion for use.
  • the liquid injection device can be provided with a discharge amount setting means for setting a discharge amount when the liquid is discharged from the cartridge unit.
  • the discharge amount setting means may be configured to set the discharge amount per unit time by changing the mode of the discharge hole according to the characteristics of the liquid.
  • the bottle portion of the cartridge unit is provided with at least a syringe portion and a gasket portion for pushing a liquid from the syringe portion toward the discharge hole, and the acting force generation mechanism is provided.
  • the liquid injection device may include a discharge number setting means for setting the number of times the liquid is discharged from the cartridge unit.
  • the liquid injection device may be provided with a driving means for driving the sliding portion of the liquid injection device in the axial direction.
  • the discharge amount setting means may include a first control unit that sets the discharge amount per unit time by controlling the drive speed of the drive means.
  • the discharge amount setting means may include a second control unit for adjusting the extrusion amount of the gasket portion by the drive means.
  • the above-mentioned driving means may be a motor provided with a driving shaft for driving the sliding portion in the axial direction.
  • the liquid injection device may include an operation unit that manually operates the sliding portion.
  • the above-mentioned acting force generating mechanism can provide a liquid injection device including a vibrating portion that vibrates the cartridge unit in the axial direction.
  • a third control unit for setting the vibration frequency of the vibration unit in the acting force generation mechanism may be provided.
  • the liquid injection device may include a fourth control unit that controls the force exerted on the cartridge unit by the acting force generating mechanism.
  • the main body of the liquid injection device is composed of a grip portion gripped by the user and an action portion including at least a cartridge mounting portion, and each of the grip portion and the action portion is provided. It is possible to provide a liquid injection device having a longitudinal angle of 50 to 80 degrees.
  • the tilt angle of the main body is detected, and when the tilt angle is within a predetermined angle range, the liquid injection device can be operated or the user is notified.
  • a fifth control unit that controls any of these may be provided.
  • the fifth control unit can also set the discharge amount per unit time according to the detected tilt angle of the main body.
  • the skin sensor that detects the approach or contact with the skin in the vicinity of the microneedle and the sixth control unit that controls the acting force generation mechanism based on the detection result are provided. It may be configured.
  • the cartridge unit in the configuration in which the acting force generating mechanism is provided with a vibrating portion, has a plurality of discharge holes, and the discharge holes are arranged at intervals in the range of 2 mm to 20 mm. It may be configured as such.
  • the system using the liquid injection device described above comprises a plurality of cartridge units each containing two or more types of liquids having different effects, and a main body.
  • the cartridge unit By using the cartridge unit while exchanging it, it is possible to provide a system capable of providing a plurality of effects.
  • the system described above includes a plurality of cartridge units and a main body, each of which includes microneedles having different lengths, arrangement densities, and distributed areas. It is possible to provide a system capable of providing a plurality of effects by using the cartridge unit while exchanging the cartridge unit.
  • a microneedle and a discharge hole are provided at the tip portion, and the tip portion is attached to the above bottle portion for use. It is also possible to provide a system characterized in that a plurality of effects can be provided by using the tip while exchanging the tip instead of exchanging.
  • the present invention has the following effects due to the above configuration.
  • the cartridge unit with a microneedle and a syringe portion for accommodating beauty essence, chemical solution, etc., it is possible to select and provide the microneedle of the optimum mode for the liquid, and the user has advanced knowledge and selection. It is possible to perform various desired actions while exchanging the cartridge unit without worrying about.
  • the liquid injection device of the present invention has two components, a cartridge unit and a sliding part driven by a motor or the like, has a small number of parts, has a simple structure, has high cost performance, and is stable in quality. ..
  • the microneedle and the syringe portion can be provided separately, so that the cartridge unit corresponding to the liquid injection device of the present invention can be easily provided even if the manufacturer is different depending on the approval system or the like. Can be provided.
  • the syringe section also contributes to mass production as a common part.
  • the discharge of the liquid can be controlled. That is, the liquid discharge speed can be adjusted by the discharge speed adjusting means, and the extrusion amount of the gasket portion can be adjusted by using the origin sensor.
  • the cartridge unit By providing an elastic support member that elastically supports a predetermined part of the syringe portion toward the gasket portion side, the cartridge unit can be supported by appropriate elasticity and pressure, and at the same time, it also contributes to waterproofing to the main body side.
  • the configuration including the vibrating portion can easily realize the discharge of the liquid.
  • the frequency and strength it is possible to adjust the discharge amount to an appropriate level.
  • the cartridge unit By providing an elastic support member that elastically supports a predetermined part of the syringe portion toward the gasket portion side, the cartridge unit can be supported by appropriate elasticity and pressure, and at the same time, it also contributes to waterproofing to the main body side.
  • the present invention can arbitrarily select various liquid types and combinations of microneedles, and contributes to the provision of a plurality of effects.
  • Explanatory drawing which shows the shape of a microneedle. The figure which shows another aspect of the tip part. Explanatory drawing of the control circuit which concerns on 2nd Embodiment of this invention. Explanatory drawing which shows the rocking state of a head part. The figure which shows the angle between the grip part and the action part.
  • FIG. 1 is a cross-sectional view illustrating the internal mechanism of the liquid injection device according to the first embodiment of the present invention
  • FIG. 2 is a perspective view of the same with the circuit board removed.
  • the present invention is a liquid injection device (1) for injecting a liquid into the skin via a microneedle (10), and is composed of a cartridge unit (20) and a main body (30).
  • a microneedle (10) provided with a discharge hole (11) is arranged at the tip, and a syringe portion (21) for accommodating the liquid behind the microneedle (10) and a syringe portion (21) for pushing out the liquid toward the discharge hole (11).
  • a gasket portion (22) for the purpose is provided, and the cartridge unit (20) is configured by these.
  • the present invention is particularly characterized in that a cartridge unit is used, and a cartridge mounting portion is arranged on the main body of the liquid injection device so that the cartridge unit can be detachably mounted. Further, as the acting force generating mechanism according to the present invention, a sliding portion for moving the gasket portion of the cartridge unit in the axial direction is provided, and the liquid in the cartridge is discharged from the discharge hole.
  • the sliding part can be slid manually or automatically.
  • a slide bar or a button-like operation unit may be provided on the main body, and the liquid may be discharged from the discharge hole by the axial operation of the gasket portion that follows the operation of the operation unit.
  • the sliding portion discloses a configuration in which the sliding portion is operated by the driving means.
  • the driving means in addition to a linear motor described later, a known driving means operating in the axial direction such as a hydraulic cylinder or an air cylinder can be used. These driving means can be controlled by the control means described below.
  • the main body (30) is contained in a head portion (31) that covers the periphery of the microneedle (10) at the tip thereof, a housing portion (32) that stores a cartridge unit (20) and other internal components, and a housing portion (32). It is composed of a linear motor (33) for driving a drive shaft, a battery (34) for supplying power, a control board (35) having a control circuit, an operation switch (36) for performing an operation, and the like.
  • the cartridge unit (31) is inserted into the cylindrical cartridge mounting portion (320) at the tip of the housing portion (32) with the head portion (31) removed, and then the head portion (31) is inserted into the housing portion (31). 32) It is fitted to the head receiving portion (321) at the tip.
  • FIG. 3 shows an aspect inside the head portion (31).
  • two convex cams (3210) are arranged on the outer peripheral surface of the head receiving portion (321), and the convex cams (3210) are engaged on the inner peripheral surface of the head portion (31). Since the matching cam groove (311) is provided, the head portion (31) can be easily attached and detached by pressing the head portion (31) against the head receiving portion (321) and rotating the head portion (321).
  • the cartridge unit (310) is provided with an elastic support member disposed inside the head portion (31), that is, a cartridge holding rubber (310) formed of rubber and elastically supported toward the gasket portion (22) in this embodiment. 31) is stably supported.
  • the cartridge holding rubber (310) has a waterproof effect of suppressing wobbling of the cartridge unit (31) and preventing liquid or the like from entering the inside from the periphery of the cartridge unit.
  • FIG. 4 is a diagram showing a state in which the cartridge unit (20) is assembled
  • FIG. 5 is a diagram showing a state in which the cartridge unit is separated.
  • the cartridge unit (20) has a tip portion (23) provided with a microneedle (10) and a discharge hole (11), a syringe portion (21) for accommodating a liquid in a cylindrical shape, and a gasket portion (22). ).
  • the liquid in the syringe portion (21) is discharged from the discharge hole (11) through a flow hole (not shown) in the tip portion (23).
  • the gasket portion (22) is composed of a sealing member (220) that seals the liquid in the syringe portion (21) and a rear end member (221) that receives a driving force from a linear motion motor (33). ..
  • the above-mentioned manual operation unit and other driving means may also have a structure in which the rear end member (221) is pushed and slid.
  • the microneedles at the tip (23) are provided with a large number of extremely small needles having a diameter and length of less than 1 mm, pass through the stratum corneum that does not allow substances to pass through, and can permeate the drug shallower than the dermis, which has many pain points. It is used not only for medical purposes such as injecting medicines such as insulin and vaccines, but also for cosmetic purposes such as injecting beauty essence.
  • PLA polylactic acid
  • collagen preferably used as the material for the microneedles.
  • the beauty essence is discharged from the discharge hole (11) provided in the flat surface around the needle, and the beauty essence permeates through the micropores of the skin made by the microneedle. Can be made to.
  • the discharge amount setting means for setting the discharge amount when discharging the liquid from the cartridge unit (20) is provided.
  • the discharge amount setting means the discharge amount per unit time may be set by changing the frictional resistance of the fluid depending on the mode of the discharge hole such as the diameter of the discharge hole, the length of the passing portion, and the adjustment of the material. .. In this configuration, even if the driving means is manually operated, an appropriate discharge amount suitable for the liquid to be used can be maintained if the driving means is operated with a certain strength.
  • the size of the discharge hole can be changed and adjusted according to the amount, momentum, viscosity, etc. of the liquid. If the momentum is too good or the amount is too large, dripping and proper application will not be possible, and the loss of beauty essence will be large. Therefore, it is important to adjust the discharge rate appropriately.
  • the discharge amount may be set by providing a pressurization chamber (not shown) in the cartridge unit (20) and adjusting the speed of the liquid flowing out from the pressurization chamber to the discharge hole without changing the mode of the discharge hole. ..
  • the liquid in the syringe portion (21) is pushed out by the linear motor (33), but even in this case, the discharge amount can be set by changing the hole diameter or the like of the discharge hole (11). ..
  • the mode of the discharge hole (11) is preferably selected according to the liquid inside. For example, when the viscosity of the liquid is 30 Pa ⁇ S, the hole diameter is about 0.2 to 1 mm, and when the viscosity is 30000 Pa ⁇ S, it is 1 mm or more. It is preferably 2 mm. In this way, depending on the liquid viscosity, changing the discharge hole enables more efficient coating and contributes to the prevention of clogging.
  • the diameter of the circular portion of the microneedle (10) is preferably 5 to 25 mm, for example, about 12 mm.
  • a beauty essence having a high viscosity for example, 5000 Pa ⁇ S or more
  • the hole diameter of the discharge hole can be selected in a wide range of 30 ⁇ m to 2 mm.
  • the liquid outlet holes are arranged at intervals of at least 100 ⁇ m to 500 ⁇ m. By ensuring such an interval, the microneedles and the discharge holes can be alternately and efficiently distributed and arranged.
  • the present invention is not limited to solid microneedles, and hollow needles may be used.
  • the discharge hole (11) has a structure of discharging from the hole of the microneedle.
  • it is common to use hollow microneedles for medical use, but it is not excluded to use solid microneedles for cosmetic purposes.
  • One end of the syringe portion (21) can be screwed with a tip portion (23) or a cap (not shown), and the other end can be sealed with a gasket portion (22) to provide various liquid cartridge units (20). ..
  • the syringe portion (21) may be configured with a transparent member so that the amount of liquid inside can be easily confirmed.
  • microneedle (10) acts on the body, the manufacturer may be limited by the approval system and laws and regulations, but by making the tip (23) separable in this way, the approved microneedle It becomes easy to apply (10) to the cartridge unit (20) of the present invention.
  • the microneedle (10) and the syringe portion (21) of the cartridge unit (20) may be integrally formed.
  • the liquid contained in the syringe portion (21) collagen, hyaluronic acid, placenta stock solution, hydroquinone, tranexamic acid, vitamin derivatives and the like can be used for cosmetic purposes.
  • minoxysider, phenasteride, Swertia japonica extract, vitamin derivatives and the like can be used for hair growth.
  • the target liquid can be used for beauty purposes, medical purposes, etc., but there is a great merit that liquids having various effects can be freely used by exchanging the cartridge unit (20). be.
  • gasket portion (22) of the cartridge unit (20) can be moved only forward and cannot be returned backward. If the gasket part (22) can be returned, foreign matter may get mixed in the liquid inside or the combination with the optimum microneedle may be impaired. Therefore, even if the gasket part (22) is ratchet-shaped and irreversible. good.
  • the rear end of the gasket portion (22) abuts on the plunger (37) that slides back and forth in the housing portion (32), and the plunger (37) is connected to the drive shaft (38) to form the sliding portion. Will be done.
  • the linear motor (33) is controlled by the control circuit (40) provided on the control board (35), slid forward by a specified amount of movement, and the gasket portion (23) of the cartridge unit (20) is extruded.
  • the control circuit (40) provided on the control board (35)
  • the gasket portion (23) of the cartridge unit (20) is extruded.
  • FIG. 6 is an explanatory diagram of the control circuit (40).
  • a linear motor (33) and an operation switch (36) are connected to a control board (35) provided with an IC or the like having a motor driver, and an origin sensor (44) and a skin sensor (45) are provided. ..
  • the control circuit (40) is provided with a discharge speed adjusting unit (41) which is a first control unit.
  • the discharge speed adjustment unit (41) simply adjusts the operating speed of the linear motor (33) to adjust the discharge speed. Is possible.
  • the discharge speed adjusting unit (41) it is possible to prevent dripping and perform necessary and sufficient application by decelerating or giving momentum depending on the part to be applied or the liquid.
  • control circuit (40) is provided with an extrusion amount control unit (42) which is a second control unit.
  • extrusion amount control unit (42) which is a second control unit.
  • An origin sensor (44) may be provided in order to more accurately detect the amount of movement of the drive shaft (38).
  • the origin sensor (44) is composed of, for example, a sensor dog (440) and a sensor (441) attached to the housing portion (32), and detects the origin position of the drive shaft (38). Then, as shown in FIG. 7, a C-shaped light-shielding plate (380) is provided at the connection position between the drive shaft (38) and the plunger (37), and the number of times of light-shielding by the light-shielding plate (380) is measured by the counter unit (46). By counting with, the extrusion amount based on the rotation speed can be detected.
  • the cartridge unit (20) is subjected to sliding resistance from the gasket portion (22) during operation, but the head portion (31) engages with the convex cam (3210) and the cam groove (311), and the cartridge holding rubber (cartridge holding rubber) (The movement amount of the drive shaft (38) and the movement amount of the gasket portion (22) coincide with each other due to sufficient rigidity against the sliding resistance force of 310).
  • the rotation speed by the counter unit (46) is stored even when the power is turned off, so that the next time it is used, it is added from the stored rotation speed, so that the extrusion amount control unit (42) continuously extrudes.
  • the amount can be controlled.
  • the extrusion amount is not limited to the above configuration, and the position of the gasket portion (22) may be detected by a known position sensor and controlled based on the position.
  • the liquid injection device of the present invention can repeatedly use the liquid of the cartridge unit (20) several tens of times instead of being used up in general, and for that purpose, the plunger (37) is provided by the position sensor (44). It is important to detect the origin position at the start of use and the position after use. As a result, it is possible to control the extrusion amount of a predetermined amount from the current position again at the start of the next use.
  • the end of use of the cartridge unit (20) can be detected by using the counter unit (46). Even if the linear motor (33) operates when the liquid inside is emptied, the gasket portion (22) hits the tip surface of the syringe portion (22) and cannot operate any more, so that the counter portion (46) is detected. The number of rotations to be performed becomes 0, and error detection (47) is performed. It is detected that the syringe portion (22) is empty at the time of error detection (47). If the syringe section (22) becomes empty, replace it with a new one.
  • the linear motor (33) can be rotated to retract the plunger (37) to the origin position and stop, and the user can be urged to replace the cartridge.
  • the drive shaft protrudes from one side as shown in the figure, and a type in which the drive shaft also protrudes from the back in order to lengthen the stroke.
  • the light-shielding plate (380) may be provided at the rear end position of the drive shaft instead of being provided at the connection position between the drive shaft (38) and the plunger (37) as described above.
  • the drive shaft itself may be a detection target by the sensor.
  • a discharge number setting means for setting the number of times the liquid is discharged from the cartridge unit.
  • control circuit (40) may be provided with a discharge control unit (43) to perform multiple discharges.
  • the drive control may be performed on the linear motor (33) a predetermined number of times.
  • the discharge control unit (43) can also control the discharge timing.
  • the timing of discharge may be arbitrarily set by operating a switch by the user, but a skin sensor (45) can be provided and discharge can be performed based on the input information.
  • the skin sensor (45) is provided on the head portion (31). As shown in FIG. 3, a terminal (312) of a skin sensor for detecting approach or contact with the skin is provided, and the terminal (312) is a connection shaft (39) provided on the upper surface of the housing (32). A minute current at the time of contact flows through the circuit board (36), and the approach or contact with the skin can be detected by a known electrostatic sensor.
  • the liquid is continuously discharged from the discharge hole (11) every time the user contacts the injection device with the skin, and the liquid is continuously discharged over a wide area of the skin. Even when injecting, it can be completed in a short time.
  • the skin sensor (45) detects the timing of leaving the skin and controls the liquid to be discharged by using this as a trigger, so that the discharged liquid stays in the head portion (31) due to the surface tension with the microneedle.
  • the amount absorbed into the skin is the sum of the amount injected from the needle and the amount retained in the head, so that more liquid should be absorbed percutaneously. Is possible. This configuration is particularly suitable when using solid microneedles.
  • the microneedles are injected by pressing the main body against the skin, but the microneedles may be connected to the vibration motor and injected into the skin a predetermined number of times by the vibration of the vibration motor. In this case, control can be performed in combination with the discharge in the discharge control unit (43).
  • FIG. 8 shows the appearance of the liquid injection device (1) according to the first embodiment of the present invention.
  • the user can grasp the rod-shaped case (2) and perform operations such as turning on / off the power, selecting a mode, and discharging with an operation switch (36) or the like.
  • the case (2) has a diameter of 3 cm to 5 cm and a total length of 20 cm to 30 cm, and has a thickness and length suitable for the user to grasp with the palm, and can stably support the main body (30).
  • the cap portion (31) can be removed and the cartridge unit (20) can be easily attached and detached.
  • the main body and multiple cartridges By combining the main body and multiple cartridges, a system that can provide multiple effects by using the cartridge units while exchanging them has been realized.
  • Multiple cartridge units differ in at least one of the length, placement density, and distributed area of the microneedles (10), such as differences depending on the part such as the face and scalp, the type of liquid, beauty and medical treatment. It is possible to realize various actions such as different uses.
  • the present invention may provide only the cartridge unit (20) as a single unit.
  • FIG. 9 is a perspective view of the liquid injection device according to the second embodiment of the present invention
  • FIG. 10 is a cross-sectional view illustrating the internal mechanism thereof.
  • the liquid injection device (100) of this embodiment is also composed of a cartridge unit (120) and a main body (130).
  • the cartridge unit (120) in this embodiment does not include a syringe portion or a gasket portion, but has a needle cap (122) as a tip portion screwed to the bottle portion (121) and the bottle portion, and a microneedle (10) when not in use. ) Is provided with a protective cap to protect it.
  • the needle cap (122) has a large number of microneedles (10) and three discharge holes (124) (shown in FIG. 12).
  • the liquid in the bottle portion (121) is discharged from the discharge hole by applying vibration to the cartridge unit (120), and the liquid is permeated into the skin by the microneedle (10).
  • the main body (130) is composed of a grip portion (140) gripped by the user and an action portion (150) internally provided with a mounting portion (151) of the cartridge unit (120), and is gripped as shown in the figure.
  • the sandwiching angle between the portion (140) and the acting portion (150) in the longitudinal direction is bent at 55 degrees.
  • the housing (141) of the grip portion (140) and the housing (152) of the working portion are integrally molded, and in this embodiment, the vibrating portion is housed together with the mounting portion (151) in the housing (152) of the working portion. Will be done.
  • the vibrating part is an outer cylinder that holds a solenoid (160), a joint (161) connected to the axis of the solenoid (160), a slider (162) that vibrates back and forth by the joint (161), and a vibrating slider (162) on the outer circumference. It is composed of (163).
  • the solenoid (160) is fixed to the housing (152) by elastic members (164) (165) so that the vibration of the solenoid (160) is not directly transmitted to the housing (152). As a result, the usability is improved and the sound is reduced.
  • the cartridge unit (120) is provided with a vibrating portion that vibrates in the axial direction, that is, in the direction equal to the protruding direction of the microneedles, as the acting force generating mechanism.
  • the solenoid (160) is provided with a spring (1602) on the outer periphery of the electromagnet (1601) and vibrates in the axial direction due to the on / off and spring action of the electromagnet. .. Vibration is transmitted to the slider (162) via the joint (161) connected to the shaft (1603) of the solenoid (160).
  • the slider (162) is provided with a plurality of slits (1621) in the axial direction to have elasticity in the radial direction, and an engaging convex portion (1622) is provided inward on the inner circumference as shown in FIG. 11B to provide a bottle portion. It is configured to engage with the engaging recess (1211) on the outer periphery of (121). Therefore, when the cartridge unit (120) is inserted into the mounting portion (151) formed in the slider (162), the cartridge unit (120) can be detachably mounted by engaging the engaging convex portion (1622) and the engaging concave portion (1211). Can be done.
  • the refraction portion of the grip portion (140) and the action portion (150) is provided with an operation switch (131) for performing an operation. Further, a battery (142) for supplying power and a control board (143) having a control circuit are housed in the housing (141) of the grip portion (140).
  • a battery (142) for supplying power and a control board (143) having a control circuit are housed in the housing (141) of the grip portion (140).
  • the configuration of the present embodiment is preferable because of its excellent weight balance, but the members are not limited in the present invention.
  • the beauty essence or the like is discharged from the discharge hole (124) by the weight of the liquid in the bottle portion (121). do. At this time, it is possible to obtain a tapping effect of tapping the skin lightly as well as permeating the beauty essence into the skin surface by vibration.
  • FIG. 12 shows a perspective view of the needle cap (122) which is the tip portion
  • FIG. 13 shows the shape of the microneedle.
  • the needle cap (122) has a circular tip that abuts on the skin surface as shown, has discharge holes (124) at three points on the circumference, and uniformly has microneedles (10) in the circle. Many are planted.
  • the diameter of the circular part is about 12 mm, and the range suitable for implementation is 5 to 25 mm.
  • the hole diameter of the discharge hole is preferably in the range of 0.8 mm to 1.6 mm at a suitable viscosity of the beauty essence (200 to 1000 mPa ⁇ S).
  • one discharge hole may be provided in the center, the beauty essence can be appropriately distributed to the microneedles (10) in the circle by providing a plurality of discharge holes.
  • FIG. 14 shows another preferred embodiment of the tip portion in the present invention.
  • FIG. 14 (b) has discharge holes (124') at the apex position of the virtual square at the tip of the circle and around the discharge holes (124'). Many microneedles (10) are planted.
  • FIG. 14 (c) has discharge holes (124') at two opposing points on the circumference at the tip of the circle.
  • FIG. 14D has a discharge hole (124') at one point on the circumference at the tip of the circle.
  • FIG. 14 (e) has one discharge hole (124') at the center position of the circular tip.
  • the diameter of the circular portion in the present invention is preferably in the range of about 5 mm to 25 mm, and particularly in the case of a large diameter close to 25 mm, four or more discharge holes are suitable as shown in FIG. 14 (b), while the diameter is 5 mm. In the case of a small diameter close to each other, even one point works sufficiently as shown in FIGS. 14 (d) and 14 (e).
  • the distance between the discharge holes at the tip is arranged in the range of 2 mm to 20 mm. That is, these are determined in relation to the size of the tip portion. For example, when the diameter of the tip portion is 5 mm and four points are arranged as shown in FIG. 14 (b), the interval becomes about 2 mm. Further, when the diameter is 25 mm and two points are arranged as shown in FIG. 14 (c), the interval becomes about 20 mm.
  • the microneedles in this embodiment have a substantially quadrangular pyramid shape having a flat portion on the upper surface, and as shown in FIG. 13, the height (H) is about 200 ⁇ m, one side (L1) on the bottom surface is about 100 ⁇ m, and one side (L2) on the upper surface. ) Is about 40 ⁇ m.
  • the ratio of L1: L2: H is preferably about 1: 2 to 3: 5 to 7 in relation to the penetrating effect and the strength of the microneedles.
  • the discharge amount when the liquid is discharged from the cartridge unit (20) is adjusted by the discharge amount setting means.
  • a similar discharge amount setting means can be provided.
  • FIG. 15 is an explanatory diagram of the control circuit (400).
  • a solenoid (160) and an operation switch (131) are connected to a control board (143) provided with an IC or the like, and a notification unit (410) that notifies the user by light emission, display, voice, etc., and tilt.
  • a sensor (411) and a skin sensor (412) are provided.
  • the control circuit (40) is provided with a vibration frequency control unit (401) which is a third control unit.
  • the vibration frequency control unit (401) can adjust the discharge amount by adjusting the frequency of turning on / off the power to the solenoid (160) and reversing the polarity. Generally, the discharge amount becomes smaller at a low frequency, and the discharge amount becomes larger at a higher frequency.
  • the vibration frequency is in a preferable range of 5 to 30 Hz, and if it is lower than 5 Hz, stable discharge cannot be obtained, and if it is higher than 30 Hz, it is continuously discharged as a general beauty essence and the discharge amount. Too many.
  • the vibration frequency control unit (401) can also change the frequency within a suitable range by operating the operation switch (131).
  • the stroke (amplitude) and the strength pushed by the solenoid (160) can be adjusted by the strength control unit (402) which is the fourth control unit.
  • the strength control unit (402) can adjust the stroke and strength by adjusting the voltage.
  • the stroke is preferably in the range of 1 mm to 3 mm, and not only the discharge amount of the beauty essence but also the tactile sensation to the skin surface of the user can be adjusted. If you want to get a strong tap feeling, set a large stroke or set a strong thrust, and if you want to hit a delicate part such as the eyes, set it weakly. It is preferable that the range of thrust can be adjusted in the range of 30% to 100% when the maximum time is 100%.
  • the angle of the needle cap (122) is also important in the configuration of this embodiment including the vibrating portion. As mentioned above, if the liquid is turned too low, the amount of discharge will be too large due to gravity, and if it is turned above the horizontal, the liquid will not be discharged. Therefore, the depression angle from the horizontal in the axial direction (protruding direction of the microneedle) is preferably in the range of 0 degrees to 25 degrees.
  • the angle between the grip portion (140) and the action portion (150) in the longitudinal direction is bent at 55 degrees so that the tip portion naturally faces downward when the grip portion (140) is gripped. Is forming.
  • the angle that tends to be the depression angle it is preferable that the angle between the gripping portion (140) and the acting portion (150) is 50 to 80 degrees.
  • the liquid injection device (100) is provided with a tilt angle sensor (411), and the angle of the device can be acquired.
  • the control circuit (400) is provided with a tilt interlocking control unit (403) which is a fifth control unit, and the solenoid (160) operates when the tilt angle by the tilt angle sensor (411) is good or inappropriate. To control.
  • the notification unit (410) may be controlled to operate only when the tilt angle is good, or to stop when the tilt angle is inappropriate. Further, when the tilt angle is good, the notification unit (410) may emit blue light, and when it is inappropriate, the notification unit (410) may emit red light to notify the user of the appropriate angle. Further, when the inclination angle is inappropriate, a warning sound may be emitted from the notification unit (410) to notify the user.
  • Whether or not to perform control by the tilt angle sensor (411) may be switched from the operation switch (131). Depending on the angle of the skin surface to be applied, it may be desired to operate even if the inclination is inappropriate, so the operation of the solenoid (160) may be set so as not to stop.
  • the tilt interlocking control unit (403) may be able to set the discharge amount per unit time according to the tilt angle. That is, the discharge amount can be set in the same manner as the discharge amount setting means in the first embodiment, the vibration frequency control unit (401) and the strength control unit (402) are instructed to control, or the tilt interlocking control unit. (403) can also set the discharge amount by adjusting the frequency, stroke, strength, and the like.
  • a head portion (153) is provided at the tip of the working portion (150).
  • the head portion (153) is connected to the housing (152) by a plunger portion (154).
  • the plunger portion (154) sandwiches a rubber O-ring and seals the needle cap (122) so that the liquid does not flow into the inside of the housing (152) due to vibration even if the liquid drips.
  • the head portion (153) is provided with a skin sensor (412), and the discharge control unit (404) can control the discharge timing. That is, by activating the solenoid (160) triggered by contact with the skin or the like, the liquid can be discharged from the discharge hole (243) each time the user contacts the injection device with the skin.
  • the timing of control by the discharge control unit (404) is arbitrary as in the first embodiment.
  • the head portion (153) may be provided with a skin-side electrode (155) made of a conductive material, and the grip portion (140) may be provided with a hand electrode (144) to exert various electrical cosmetic effects.
  • a weak electric current may be applied to the skin surface from the skin surface side electrode (155) to exert an action called iontophoresis to improve the penetration of the beauty essence.
  • the permeation effect can be further enhanced by matching the tap with the vibrating portion.
  • electrical muscle stimulation called EMS (Electrical Muscle Stimulation), which applies a current having a frequency of several Hz to several kHz, or RF current, for example, a high frequency of about 1 Mhz can be applied from the skin surface side electrode.
  • the head portion (153) can be swung to soften the impact.
  • the skin surface side electrode (155) can swing on the head portion (153) in a range of about + -10 degrees, and is configured to avoid excessive interference with the skin. ing.
  • the configuration in which the solenoid is used to realize the vibrating part is disclosed, but the mechanism for generating the vibration is arbitrary.
  • a vibration motor, ultrasonic vibration, a vibration speaker, an air type vibrator, or the like can be appropriately used.
  • the housing may be rod-shaped in a configuration using a vibrating portion, or a refracted main body may be used in a configuration including a sliding portion.
  • a substantially T-shaped main body may be used.
  • the sandwiching angle between the acting portion (170) and the grip portion (171) is 70 degrees as shown in FIG. 17 (A).
  • the configuration is not limited to the configuration using the sliding portion, and any pinching angle such as 90 degrees or 110 degrees may be used in the configuration using the vibrating portion or other acting force generating mechanism as shown in FIGS. 17B and 17C.

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Medical Informatics (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
PCT/JP2021/025124 2020-07-02 2021-07-02 液体注入装置、及びそのシステムとカートリッジユニット WO2022004876A1 (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CN202180028185.5A CN115397502A (zh) 2020-07-02 2021-07-02 液体注入装置及其系统和药筒单元
JP2022534125A JPWO2022004876A1 (xx) 2020-07-02 2021-07-02

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2020114884 2020-07-02
JP2020-114884 2020-07-02

Publications (1)

Publication Number Publication Date
WO2022004876A1 true WO2022004876A1 (ja) 2022-01-06

Family

ID=79316468

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2021/025124 WO2022004876A1 (ja) 2020-07-02 2021-07-02 液体注入装置、及びそのシステムとカートリッジユニット

Country Status (3)

Country Link
JP (1) JPWO2022004876A1 (xx)
CN (1) CN115397502A (xx)
WO (1) WO2022004876A1 (xx)

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005527249A (ja) * 2001-09-12 2005-09-15 ベクトン・ディキンソン・アンド・カンパニー ペンデバイスに基づいた薬物投与のためのマイクロ針および該マイクロ針の使用法
JP2009000557A (ja) * 2000-12-22 2009-01-08 Dca Design Internatl Ltd 電子制御ユニットを具備するペン型注入装置
JP2014516634A (ja) * 2011-04-20 2014-07-17 アムゲン・インコーポレーテッド 自動式注射装置
JP2017525507A (ja) * 2014-08-28 2017-09-07 ユニトラクト シリンジ プロプライエタリイ リミテッドＵｎｉｔｒａｃｔ Ｓｙｒｉｎｇｅ Ｐｔｙ Ｌｔｄ 薬物送達デバイス用の皮膚検知システム
KR20200019399A (ko) * 2018-08-14 2020-02-24 주식회사 브리텍 마이크로 니들 피부미용기기

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2015217176A (ja) * 2014-05-19 2015-12-07 株式会社根本杏林堂 薬液注入装置
KR101705317B1 (ko) * 2014-07-11 2017-02-09 주식회사 현대메디텍 주사기 결합식 자동약액주입장치
CN107708767A (zh) * 2015-04-16 2018-02-16 株式会社根本杏林堂 化学溶液注入装置、化学溶液注入装置的控制方法和计算机程序

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009000557A (ja) * 2000-12-22 2009-01-08 Dca Design Internatl Ltd 電子制御ユニットを具備するペン型注入装置
JP2005527249A (ja) * 2001-09-12 2005-09-15 ベクトン・ディキンソン・アンド・カンパニー ペンデバイスに基づいた薬物投与のためのマイクロ針および該マイクロ針の使用法
JP2014516634A (ja) * 2011-04-20 2014-07-17 アムゲン・インコーポレーテッド 自動式注射装置
JP2017525507A (ja) * 2014-08-28 2017-09-07 ユニトラクト シリンジ プロプライエタリイ リミテッドＵｎｉｔｒａｃｔ Ｓｙｒｉｎｇｅ Ｐｔｙ Ｌｔｄ 薬物送達デバイス用の皮膚検知システム
KR20200019399A (ko) * 2018-08-14 2020-02-24 주식회사 브리텍 마이크로 니들 피부미용기기

Also Published As

Publication number Publication date
JPWO2022004876A1 (xx) 2022-01-06
CN115397502A (zh) 2022-11-25

Similar Documents

Publication Publication Date Title
US11684718B2 (en) Device and method for repetitive needleless injection
EP2420265B1 (en) Needle unit and dermatological liquid injection apparatus using same
US9022997B2 (en) Microneedle unit capable of controlling fluid delivery
CA2684861C (en) Method and apparatus for the formation of multiple microconduits
JP4469610B2 (ja) 皮膚アクセス部材
US20090270834A1 (en) Drug delivery device
KR101489397B1 (ko) 동시전기자극형 약물주사장치
RU2021139906A (ru) Устройство для подкожной доставки текучего лекарственного средства
JP6183366B2 (ja) マルチマイクロニードルデバイス使用流体注入器操作器具
JP6513102B2 (ja) 薬液注入装置
KR20150073166A (ko) 멀티 마이크로 니들 디바이스 사용 유체 주입기 조작 기구
US20130066263A1 (en) Microjet drug delivery system and microjet injector
WO2022004876A1 (ja) 液体注入装置、及びそのシステムとカートリッジユニット
KR20180055066A (ko) 액체공급 롤러장치
US20070118093A1 (en) High-speed jet devices for drug delivery
KR102126008B1 (ko) 약물전달시스템용 니들유닛
KR20160111191A (ko) 피부치료용 핸드피스
CN116018176A (zh) 带有针状突起的器件
EP3458141A1 (en) System and method for applying microneedles
US20200353171A1 (en) Method and device for the needle-free injecting of fluid into a substrate
KR101169759B1 (ko) 앰플 인젝션 프로브
WO2018015499A1 (en) Needle-free skin piercing system and method
KR102214553B1 (ko) 약액 주입을 위한 미세바늘 스탬프 기기
UA125209C2 (uk) Пристрій для підшкірної ін'єкції з електричною стимуляцією нерва
JP2024524966A (ja) 薬物注入性能の調節が可能な無針注射システム

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 21834597

Country of ref document: EP

Kind code of ref document: A1

ENP Entry into the national phase

Ref document number: 2022534125

Country of ref document: JP

Kind code of ref document: A

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 21834597

Country of ref document: EP

Kind code of ref document: A1