WO2021260141A1 - Composition - Google Patents

Composition Download PDF

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Publication number
WO2021260141A1
WO2021260141A1 PCT/EP2021/067402 EP2021067402W WO2021260141A1 WO 2021260141 A1 WO2021260141 A1 WO 2021260141A1 EP 2021067402 W EP2021067402 W EP 2021067402W WO 2021260141 A1 WO2021260141 A1 WO 2021260141A1
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WO
WIPO (PCT)
Prior art keywords
composition
present
amount
less
ethanol
Prior art date
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PCT/EP2021/067402
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English (en)
Inventor
Serge Bettonville
Michel Clarembeau
Raphael ESSERS
Alain TENDIL
Original Assignee
Ineos Services Belgium Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by Ineos Services Belgium Sa filed Critical Ineos Services Belgium Sa
Publication of WO2021260141A1 publication Critical patent/WO2021260141A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/80—Polymers containing hetero atoms not provided for in groups A61K31/755 - A61K31/795
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/40—Peroxides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/22—Peroxides; Oxygen; Ozone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A61K8/342—Alcohols having more than seven atoms in an unbroken chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
    • A61K8/89—Polysiloxanes
    • A61K8/891—Polysiloxanes saturated, e.g. dimethicone, phenyl trimethicone, C24-C28 methicone or stearyl dimethicone
    • A61K8/894—Polysiloxanes saturated, e.g. dimethicone, phenyl trimethicone, C24-C28 methicone or stearyl dimethicone modified by a polyoxyalkylene group, e.g. cetyl dimethicone copolyol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/02—Local antiseptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/10—Washing or bathing preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/16—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using chemical substances
    • A61L2/18—Liquid substances or solutions comprising solids or dissolved gases

Definitions

  • the present invention relates to compositions suitable for cleansing and disinfecting, and in particular to compositions based on ethanol.
  • Ethanol compositions are widely used for their cleansing and disinfectant properties. Typical applications/formulations include compositions for “Hands and Small surface”, “Screens”, “Large surface/foaming” and “Surface MED”. Depending on the application a range of different components/additives may be present in the composition.
  • ethanol compositions for use on skin often include other components, such as emollients, designed to leave the skin with a smooth feel.
  • ethanol compositions can also include further components, including for example those designed to leave a pleasant smell.
  • compositions with ethanol concentrations of 60% to 95% are deemed safe and effective for disinfection by the United States Food and Drug Administration (US FDA), the US Centers for Disease Control and Prevention (CDC) and the World Health Organisation (WHO) including for use against SARS-CoV-2.
  • US FDA United States Food and Drug Administration
  • CDC US Centers for Disease Control and Prevention
  • WHO World Health Organization
  • Higher ethanol concentrations in this range can reduce the contact time or increase the effectiveness of the compositions, but this is often at the expense of the risk of dryness, noted above, or other epidermal irritation.
  • many commercially available ethanol compositions and many compositions described in the art limit the ethanol content to the lower end of the effective range. For example, many compositions have an ethanol composition of 60-65wt%, or have lower ethanol concentrations used in conjunction with propanol.
  • WHO formulation The World Health Organisation recommended Handrub formulation using ethanol (hereinafter “WHO formulation”), for example, comprises (v/v) ethanol 80%, glycerol 1.45% and hydrogen peroxide 0.125%.
  • compositions which has high ethanol content. It would also be desirable to find a composition which can either be used for different applications without modification, or with only relatively minor changes of the composition e.g. by using the same or a limited number of common components with only minor additions or concentration changes for different applications. This would enable a manufacturing plant producing such compositions to be easily and also efficiently switched to products for different applications depending on demand.
  • polyether-modified polysiloxanes can be used as components of light alcohol (C1-C4) antimicrobial compositions.
  • EP 3 058 821 Bl describes foaming product compositions comprising 50 to 90 wt. of a C2-C4 alcohol and comprising PEG-8 to PEG-12 linear dimethicone surfactant.
  • PEG is polyethylene glycol
  • EP 1 858 323 Bl for example, claims utilization of bis-PEG- [10-20] dimethicone as foamable alcohol composition for use as an alcoholic foam for personal hygiene.
  • the compositions comprise: a) ethanol, a mixture of n-propanol an ethanol, a mixture of isopropanol and ethanol, or n-propanol present in an amount in the range of 60% v/v to 90 % v/v of the total composition, or isopropanol in an amount in the range of 70% v/v to 90 % v/v of the total composition.
  • Such compounds are also known in the art.
  • EP 1830636 Bl describes a composition comprising 52 to £99 wt %, relative to the total quantity of the foam composition, of an alcohol or mixture of alcohols, a surfactant or a surfactant mixture, and at least one polyalkylene glycol, wherein the surface tension of the surfactant or surfactant mixture lies in the range of ⁇ 15 dyn/cm of the surface tension of alcohol or alcohol mixture.
  • a preferred composition comprises bis-PEG/PPG-20/20 dimethicone, and in particular 55 to 96 wt % of ethanol, 1 to 10 wt % of bis-PEG/PPG- 20/20 dimethicone.
  • compositions such as those described in EP 1830636 Bl are effective, especially if higher ethanol concentrations are selected, when used for cleansing on solid surfaces such compositions have been found to leave unacceptable levels of greasy films, and when used as antiseptics, they have been found to give an oily sensorial feel.
  • polyalkylene glycol-modified polysiloxanes having at least two different polyalkylene glycol groups can be found in EP 2654420 Bl.
  • compositions are exemplified comprising a surfactant comprising a mixture of bis-PEG,PPG-20/5 PEG,PPG-20/5-dimethicone, methoxy-PEG/PPG-25/4-dimethicone and capryl-/caprin-triglyceride.
  • a surfactant comprising a mixture of bis-PEG,PPG-20/5 PEG,PPG-20/5-dimethicone, methoxy-PEG/PPG-25/4-dimethicone and capryl-/caprin-triglyceride.
  • Such compositions have high alcohol contents, but also include a large number of additional components.
  • a composition which comprises a) At least 70 wt% to at most 90 wt% ethanol, b) 0.01wt% to less than 1 wt. % of polyalkylene glycol-modified polysiloxane, wherein the polyalkyleneglycol-modified polysiloxane comprises at least two different polyalkylene glycol groups and wherein the polyalkylene glycol groups are present in an amount corresponding to at least 40 moles of alkylene glycol per mole of polysiloxane, c) Optionally up to 0.5wt% of a foam stabiliser, d) Optionally up to 5wt% of a peroxide, and e) At least 5wt% water.
  • Component (a) is ethanol, and ethanol is present in an amount of at least 70wt% to at most 90wt% of the composition. Preferably, the ethanol is present in an amount of 85wt% or less, and more preferably of 80wt% or less.
  • the minimum concentration is preferably at least 71wt%, such as at least 72wt%.
  • the ethanol used to prepare the composition according to the present invention may be any suitable grade. It may be noted that the “ethanol” as used to produce the composition may comprise quantities of water e.g. as an impurity. This does not cause any issues since water is also a component of the composition. For avoidance of doubt, however, as used herein reference to the amount of ethanol in the composition refers to the quantity of the compound ethanol i.e. C 2 H 5 OH in the composition. Thus, any water (or other compound which may be present, such as a denaturant) in the ethanol used to prepare the composition is discounted in relation to the amount of ethanol in the composition of the present invention. (In contrast, however, any water will contribute to the total amount of water in the composition. Thus, the amount of water in step (e) should include any water introduced with the ethanol or other components and any water separately added to the composition.)
  • Component (b) is a polyalkylene glycol (“PAG”)-modified polysiloxane. It is present in an amount of 0.01wt% to less than lwt% of the composition. Component (b) is preferably present in an amount of less than 0.99 wt%, such as 0.95wt% or less or 0.90wt% or less. More preferably the component (b) is present in an amount of 0.80wt% or less, and most preferably 0.50wt% or less of the composition. It has in particular been found that concentrations below 0.50wt%, and even below 0.30wt%, are still highly effective. A preferred minimum is 0.02wt%, such as 0.03wt%. A particularly preferred range is 0.03wt% to 0.30wt%, such as 0.05wt% to 0.25wt%.
  • PAG polyalkylene glycol
  • the polyalkylene glycol-modified polysiloxane may be any suitable polyalkylene glycol-modified polysiloxane which comprises at least two different polyalkylene glycol groups. Typically, and preferably, at least one is polyethylene glycol or polypropylene glycol.
  • the second and any further polyalkylene glycol groups may then be selected from polyalkylene glycols where the alkylene has 4 to 8 carbons. Preferably, however, both polyethylene glycol and polypropylene glycol are present in the polyalkylene glycol- modified polysiloxane.
  • the polyalkylene glycol-modified polysiloxane is also characterised in that the polyalkylene glycol groups are present in an amount corresponding to at least 40 moles of alkylene glycol per mole of polysiloxane.
  • the number of alkylene glycol groups is typically described in the name of the component.
  • PEG/PPG-18/18 dimethicone for example, has an average of 18 ethylene glycol groups (in the PEG chain) and 18 propylene glycol groups (in the PPG chain) as a single end group on the polysiloxane.
  • this compound has an average of 36 alkylene glycol groups per molecule, corresponding to 36 moles of alkylene glycol per mole of polysiloxane.
  • alkylene glycol groups it can also be considered that this corresponds also to the same number of alkylene oxide groups.
  • PEG/PPG-18/18 dimethicone may, for example, also be referred to as having an average of 18 ethylene oxide groups and 18 propylene oxide groups per molecule or as having 18 moles of ethylene oxide and 18 moles of propylene oxide per mole of polysiloxane. As used herein these are all synonymous.
  • the requirement for a minimum of 40 moles of alkylene glycol per mole of polysiloxane is achieved by the presence of two or more polyalkylene glycol modifications on the polysiloxane chain.
  • the polyalkylene glycol-modified polysiloxane is preferably a bis-polyalkylene glycol-modified polysiloxane.
  • Such compounds have polyalkylene glycol chains on both ends of the polysiloxane chain, thereby doubling the number of polyalkylene groups present.
  • Bis-PEG/PPG-20/20 dimethicone for example, has 80 alkylene glycol groups per molecule (40 EG and 40 PG) corresponding to 80 moles of alkylene glycol per mole of polysiloxane.
  • the polyalkylene glycol-modified polysiloxane is characterised in that the polyalkylene glycol groups are present in an amount corresponding to at least 42 moles, more preferably at least 44 moles of alkylene glycol per mole of polysiloxane. Most preferred compounds have at least 50 moles, such as at least 60 moles, and most preferably at least 70 moles of alkylene glycol per mole of polysiloxane. Typically, the polyalkylene glycol groups are present in an amount corresponding to up to 100 moles of alkylene glycol per mole of polysiloxane, more preferably up to 90, and most preferably up to 84 moles of alkylene glycol per mole of polysiloxane.
  • the polyalkylene glycol- modified polysiloxane comprises polypropylene glycol as one of at least two different polyalkylene glycol groups.
  • the polypropylene glycol groups are present in an amount corresponding to at least 20 moles of propylene glycol per mole of polysiloxane, such as at least 25 moles, and more preferably at least 30 moles of propylene glycol per mole of polysiloxane.
  • the polypropylene glycol groups correspond to at least 30%, such as at least 40% of the total number of polyalkylene glycol groups present.
  • the polyalkylene glycol-modified polysiloxane has (exactly) two different polyalkylene glycol groups, and most preferably is a bis-PAGl/PAG2 -modified polysiloxane, where PAG1 and PAG2 represent the two different polyalkylene glycol groups.
  • PAG1 and PAG2 represent the two different polyalkylene glycol groups.
  • at least one of the polyalkylene glycol groups is polyethylene glycol or polypropylene glycol.
  • the two groups are polyethylene glycol and polypropylene glycol.
  • the second group is preferably selected from polyalkylene glycols where the alkylene has 4 to 8 carbons.
  • the preferred polysiloxanes are polydimethylsiloxanes, also known as “dimethicones”.
  • the most preferred polyalkylene glycol-modified polysiloxanes are bis-PEG/PPG-X/Y-dimethicones, where “X” and “Y” represent the chain length of the PEG and PPG polymer chains respectively.
  • X represents dimethicone which is blocked at both ends with an average of X moles of ethylene glycol and an average of Y moles of propylene glycol.
  • X + Y will be at least 20 for the requirement that polyalkylene glycol groups are present in an amount corresponding to at least 40 moles of alkylene glycol per mole of polysiloxane to be met, and higher for the preferred embodiments.
  • the alkylene groups present in such molecules correspond to an amount of 2*(X+Y)” moles of alkylene glycol per mole of polysiloxane.
  • X and Y are each from 5-26, more preferably 16-24, and most preferably 18-22.
  • X and Y are such that 1/5 ⁇ X/Y ⁇ 5 and more preferably 1/2 ⁇ X/Y ⁇ 2.
  • X and Y are equal. Most preferably they are both 20 i.e. the polyalkylene glycol-modified polysiloxane is bis-PEG/PPG-20/20 dimethicone.
  • Suitable commercial products which can be used are the those available under the trade name ABIL® B 8832 from Evonik (which is a bis-PEG/PPG- 20/20 dimethicone), XIAMETERTM OFX-0190 Fluid (bis-PEG/PPG -18/18 dimethicone) from Dow or BELSIL® OW 1500 (bis-PEG/PPG-20/20 dimethicone) from Wacker.
  • compositions as claimed with ethanol concentrations of at least 70 wt.%, but low levels (less than lwt%) of polyalkylene glycol-modified polysiloxane (and in particular bis-PEG/PPG-20/20 dimethicone) can deliver desired properties for cleansing and disinfection applications while delivering pleasant skin feel.
  • compositions are highly foamable. This is surprising because, for compositions with water and a low alcohol concentration replacing PEG by PPG (or other longer chain) units on the polyalkylene chains of modified polysiloxane would be expected to reduce their foaming capability due to the reduction in polarity of the chain.
  • SILWET® L-7220 by Momentive Performance Materials having chain made from 20% ethylene oxide and 80% propylene oxide is described as a foam controller (EP1173267B1).
  • ethanol content compositions of the types claimed herein the addition of PPG gives higher foaming.
  • composition of the present invention allows the production of commercially suitable formulations with very low levels of additives which is not only valuable in terms of raw material costs and processing but also limits the risks of having biocide activity reduction due to some of the additives. Further, the composition can be used for different applications without modification, or with only relatively minor changes of the composition.
  • Typical applications include:
  • Formulations suitable for these applications are typically those used for human hygiene, but can be applied on small surface areas.
  • the formulations may typically be provided in the form of impregnated wipes or in relatively small volume bottles. Gelling agents may be added, for example, to form gels e.g. handgels.
  • Containers are typically low volume e.g. ⁇ 100ml.
  • the preferred formulation therefore comprises none of components (c) and (d).
  • the “balance” is the water.
  • the same “base composition” comprising (a), (b) and water may be used, but preferably component (c) is also present i.e. up to 0.5wt% of a foam stabiliser.
  • suitable foam stabilisers are fatty alcohols, and particularly straight chain C6 to C20 primary alcohols, and more preferably straight chain C8 to C16 primary alcohols.
  • a particularly preferred foam stabiliser is 1- Tetradecanol, commonly referred to as myristyl alcohol.
  • Component (c), when present, is present in a maximum amount of 0.5wt%, preferably less than 0.2wt%, and most preferably less than 0.1 wt%.
  • a preferred range is 0.05 to 0.1 wt%.
  • compositions of the present invention can be applied, and again with only minor modifications to the formulation is “Surface MED”.
  • the composition comprising all of components (a)-(e).
  • Components (a)-(c), including both the preferred components and their concentrations in the composition, are preferably as already set out for the other applications above.
  • a most preferred composition for this application can comprise essentially the same composition used for “Large surface” applications to which component (d) is added.
  • Component (d), when present, is a peroxide. Any suitable peroxide may be used, either organic or inorganic, but hydrogen peroxide is preferred. Such components are added in situations where addition biocidal properties may be desired.
  • the amount of peroxide/component (d) is less than 4wt%, for example in the range 1 to 3wt%.
  • Component (e) is water. It is present in an amount of at least 5wt%. Due to the requirements on other components it must be present at less than 30wt% in total. Generally the water forms the balance of the composition i.e. such that all components present sum to 100%. Water is typically present in an amount of at least 10wt%, such as at least 15wt%, and usually at least 20wt%. Preferred ranges are 15 to 28wt% and 20 to 25wt%. As noted already, water may be introduced with other components of the composition, such as the ethanol and/or may be introduced separately.
  • the present invention does not, unless otherwise stated, exclude that other additives could be added for any particular application.
  • a thickening agent may be added to increase the viscosity of the composition and make it easier to dispense or apply, or simply to improve the feel of the product.
  • the composition of the present invention can be thickened by addition of an acrylate copolymer, such as Aqua SF1 from Lubrizol.
  • Such additives can, if required, be neutralized with an organic base such as AMP® Ultra PC2000 from Dow.
  • Any thickening agent, where used is preferably used in an amount of less than 3wt% of the total composition, preferably of less than 2wt%, such as 0.2 to 1 wt%.
  • thickening agent may be added in an aqueous or ethanolic solution comprising the active component e.g. acrylate copolymer, and it is the amount of acrylate copolymer which is preferably less than 3wt% of the total composition independently of the amount of solution added. (The water or ethanol content of which is counted towards the amount of this component in the final composition.)
  • any components other than components (a)-(e) are added to the composition, particularly less than 3wt%, more preferably less than lwt% of any components.
  • other additives are not deliberately added to the formulation.
  • “deliberately added” is meant, components and additives which are added intentionally to the composition to obtain a specific effect. This definition excludes components which may be impurities in the components or in the solutions by which the components are combined, which as used herein are not considered to be intentionally added.
  • the composition is considered to consist essentially of components (a), (b), (c) (where present), (d) (where present), and (e).
  • other additives are not deliberately added to the formulation other than a thickening agent i.e. the composition may be considered to consist essentially of components (a), (b), (c) (where present), (d) (where present), (e) and a thickening agent.
  • the composition comprises less than lwt% of glycerol, and preferably no glycerol is present.
  • the use of polyalkylene glycol-modified polysiloxane allows glycerol to be excluded whilst providing improved compositions compared to compositions comprising glycerol, such as the WHO formulation discussed previously.
  • the present invention also does not, unless otherwise stated, exclude that minor changes in the concentrations of the common components may be made depending on the application.
  • compositions comprising 75wt% ethanol and 0.15wt% PEG/PPG-20/20 dimethicone are described in the Examples for “Hand and Small Surface applications”.
  • compositions with lower content of PEG/PPG- 20/20 dimethicone this also being shown in the Examples.
  • a change of the composition of this type is relatively trivial for a manufacturer and may be preferred even if it adds some additional process control steps or plant scheduling requirements.
  • compositions of the present invention are generally of an approximately neutral pH although they may also be slightly alkaline, as is typical for many soaps.
  • compositions comprising solely the components (a), (b) and (e) (i.e. ethanol, the polyalkyleneglycol-modified polysiloxane and water) will usually have a pH in the range 6.5 to 8.5.
  • the pH of the composition more generally i.e. even when other components are present, is also preferably from about 6.5 to about 8.5, although values outside this range, including up to about 10, are acceptable.
  • compositions according to the present invention may be used/provided for use in any suitable form.
  • the compositions may be provided in bottles of any suitable volume depending on the application, optionally with a pump head if required for larger bottles, or they can also be delivered by means of a spraying device or via wipes.
  • the viscosity may vary widely, particularly depending on the desired application. Typically the viscosity is between 1 and 10,000 mPa.s (1 cP), with the higher values being applicable in particular where a thickening agent is added to form a gel as already noted.
  • the viscosity of the compositions is typically at least 500 mPa.s, such at least 800 mPa.s, and most preferably in the range 1000 to 8000 mPa.s. (Viscosity may generally be measured by any suitable device, but in the present invention is measured on a Brookfield DV2T RV model, on a 500ml sample, using a spindle # 3 and at a speed of 20 rpm for 1 minute.)
  • the present invention allows producing foamable formulations with concentrations ⁇ 1 wt. % of polyalkyleneglycol-modified polysiloxane that upon contact with human bodies leave smooth and pleasant skin feel.
  • the compositions are however also suitable for other applications as noted.
  • ABIL® B 8832 from Evonik (which is a bis-PEG/PPG-20/20 dimethicone) is dissolved in pure ethanol to form a solution with a concentration of 10wt% bis-PEG/PPG-20/20 dimethicone.
  • the dissolution is achieved by slow stirring over about 5 minutes to minimise foaming.
  • this solution is then further diluted with stirring in a blender with pure ethanol to provide a solution comprising 0.2wt% bis- PEG/PPG-20/20 dimethicone.
  • this solution is mixed with water (approx three parts of this solution with one part of water) in the blender to give a final composition which comprises 75wt% ethanol, 0.15wt% of bis-PEG/PPG-20/20 dimethicone and a balance of water.
  • Example 1 The preparation of Example 1 was repeated except that in the second step the solution was diluted with stirring in a blender with pure ethanol to provide a solution comprising 0.067wt% bis-PEG/PPG-20/20 dimethicone. In the third step this solution is mixed with in the blender to give a final composition which comprises 75wt% ethanol, 0.05wt% of bis-PEG/PPG-20/20 dimethicone and a balance of water.
  • Example 3 The preparation of Example 3 is similar to Example 1. However, in the first step a second solution was prepared by dissolving Lanette 14 from BASF (myristyl alcohol) in pure ethanol to form a solution with a concentration of 10wt% myristyl alcohol. The dissolution is achieved by slow stirring over about 10 minutes.
  • BASF myristyl alcohol
  • the required amounts of both solutions from the first step were mixed and then diluted with stirring in a blender with pure ethanol to provide a solution comprising bis-PEG/PPG-20/20 dimethicone and myristyl alcohol.
  • this solution is mixed with water in the blender to give a final composition which in this Example comprises 75wt% ethanol, 0.25wt% of bis-PEG/PPG- 20/20 dimethicone, 0.8wt% myristyl alcohol and a balance of water.
  • Example 3 The preparation of Example 3 is repeated except that when mixed with water hydrogen peroxide is added, to give a final composition comprising 75wt% ethanol, 0.25wt% of bis-PEG/PPG-20/20 dimethicone, 0.8wt% myristyl alcohol. 2.5wt% hydrogen peroxide and a balance of water.
  • composition used for Comparative Example 1 is the WHO recommended Handrub formulation using ethanol comprising (v/v) ethanol 80%, glycerol 1.45%, hydrogen peroxide 0.125% and a balance of water.
  • Comparative Example 2 is denatured ethanol. Comparative Example 3
  • Comparative Example 3 is prepared in the same way as Example 3, except that the final composition comprises 2wt% bis-PEG/PPG-20/20 dimethicone is used.
  • Examples 1 and 2 and Comparative Examples 1 and 2 were all tested as hand sanitisers. Although all compositions are effective at disinfecting the hands, the compositions according to the present invention were found to provide a better feel on the skin of the user. This was both compared to Comparative Example 2 (denature ethanol), which left a significant feeling of dryness on the skin, and also compared to Comparative Example 1 (WHO formulation). Thus, the use of low levels of bis-PEG/PPG-20/20 dimethicone provides an improved composition for use as a hand sanitiser.
  • Example 2 was also tested as a cleanser for computer screens. It was found to be very effective in cleansing and disinfecting without leaving any undesired traces on the screen.
  • Example 3 and Comparative Example 3 were tested in a large surface application. Comparative Example 3 provided excellent cleansing performance, but an oily/greasy residue was left on the surface. Example 3 also provided excellent cleansing performance, but without leaving any noticeable residue. This shows that excellent cleansing and disinfecting can be achieved without leaving residue by using low levels of bis-PEG/PPG- 20/20 dimethicone.
  • Example 4 was also tested in a large surface application.
  • the Example also provided excellent cleansing performance, without leaving any noticeable residue.
  • the hydrogen peroxide improved the biocidal effectiveness, making this suitable also for applications in a medical environment.

Abstract

La présente invention concerne des compositions appropriées pour le nettoyage et la désinfection et, en particulier, l'invention concerne une composition qui comprend a) au moins 70 % en poids à au plus 90 % en poids d'éthanol, b) 0,01 % en poids à moins de 1 % en poids de polysiloxane modifié par du polyalkylène glycol, le polysiloxane modifié par du polyalkylène glycol comprenant au moins deux groupes polyalkylène glycol différents et les groupes polyalkylène glycol étant présents à raison d'au moins 40 moles d'alkylène glycol par mole de polysiloxane, c) éventuellement jusqu'à 0,5 % en poids d'un stabilisant de mousse, d) éventuellement jusqu'à 5 % en poids d'un peroxyde et e) au moins 5 % en poids d'eau.
PCT/EP2021/067402 2020-06-26 2021-06-24 Composition WO2021260141A1 (fr)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023074338A1 (fr) * 2021-10-26 2023-05-04 株式会社 資生堂 Composition contenant de l'éthanol

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1173267B1 (fr) 1999-03-23 2003-12-17 Crompton Corporation Agents de regulation de la mousse pour tensioactifs au silicone
WO2006066888A2 (fr) * 2004-12-21 2006-06-29 Stockhausen Gmbh Mousse a pomper contenant de l'alcool
WO2011013009A2 (fr) * 2009-07-29 2011-02-03 Foamix Ltd. Compositions hydro-alcooliques moussantes non tensioactives, mousses légères, et leurs utilisations
EP2654420B1 (fr) 2010-12-22 2016-10-19 Bode Chemie GmbH Composition antimicrobienne présentant des propriétés de soins cutanés
EP1858323B1 (fr) 2005-03-07 2017-11-08 Deb IP Limited Compositions moussantes a haute teneur en alcool avec des agents tensioactifs a base de silicone
EP3058821B1 (fr) 2008-07-24 2018-08-29 Ecolab Inc. Compositions moussantes d'alcool avec des tensioactifs de diméthicone choisis
US20190343116A1 (en) * 2018-05-10 2019-11-14 Protair-X Health Solutions Inc. Foam sanitizer composition

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1173267B1 (fr) 1999-03-23 2003-12-17 Crompton Corporation Agents de regulation de la mousse pour tensioactifs au silicone
WO2006066888A2 (fr) * 2004-12-21 2006-06-29 Stockhausen Gmbh Mousse a pomper contenant de l'alcool
EP1830636A2 (fr) 2004-12-21 2007-09-12 Stockhausen GmbH Mousse a pomper contenant de l'alcool
EP1830636B1 (fr) 2004-12-21 2018-01-24 Deb IP Limited Mousse a pomper contenant de l'alcool
EP1858323B1 (fr) 2005-03-07 2017-11-08 Deb IP Limited Compositions moussantes a haute teneur en alcool avec des agents tensioactifs a base de silicone
EP3058821B1 (fr) 2008-07-24 2018-08-29 Ecolab Inc. Compositions moussantes d'alcool avec des tensioactifs de diméthicone choisis
WO2011013009A2 (fr) * 2009-07-29 2011-02-03 Foamix Ltd. Compositions hydro-alcooliques moussantes non tensioactives, mousses légères, et leurs utilisations
EP2654420B1 (fr) 2010-12-22 2016-10-19 Bode Chemie GmbH Composition antimicrobienne présentant des propriétés de soins cutanés
US20190343116A1 (en) * 2018-05-10 2019-11-14 Protair-X Health Solutions Inc. Foam sanitizer composition

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023074338A1 (fr) * 2021-10-26 2023-05-04 株式会社 資生堂 Composition contenant de l'éthanol

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