WO2021246799A1

WO2021246799A1 - Intraocular lens

Info

Publication number: WO2021246799A1
Application number: PCT/KR2021/006932
Authority: WO
Inventors: 최병찬
Original assignee: 최병찬
Priority date: 2020-06-04
Filing date: 2021-06-03
Publication date: 2021-12-09
Also published as: KR102559052B1; KR20210150681A

Abstract

The present invention comprises: an optic part that serves as a lens of the intraocular lens; and a haptic part that extends from the optic part and serves to support the position of the optic part, wherein at least one of a first pattern portion, which includes a first concave portion or a first convex portion having a fine concavo-convex portion formed on a surface thereof, and a second pattern, which includes a second concave portion or a second convex portion having a fine concavo-convex portion formed on a surface thereof, is alternately or repeatedly positioned on at least one side of the optic part and the haptic part, and at least one of the first concave portion, the first convex portion, the second concave portion, and the second convex portion has a different size, thereby preventing recurrence of eye diseases such as late-onset cataracts by inhibiting cell mobility and controlling the direction of cell migration.

Description

intraocular lens

The present invention relates to an intraocular lens.

In general, the human eye is similar to the structure and function of a camera. At the rear of the pupil, there is a crystalline lens made of transparent tissue in the shape of a convex lens, which functions as a camera lens. Cataract is induced when the lens becomes cloudy due to external damage or use of unnecessary eye drops, radiation exposure, and exposure to various harmful electromagnetic waves.

One of the surgical methods for the treatment of such cataracts is a method of implanting an artificial lens that can replace the function of the lens. In this case, in most cases, the intraocular lens is operated so as to be inserted into a portion called a capsuleer bag in the eye or between the capsuleer bag and the iris. However, even after the procedure, there is a possibility that the turbidity reoccurs due to the proliferation, clustering, and movement of the cells that cause late-onset cataracts.

Therefore, there is a need for a technology capable of delaying or inhibiting the proliferation, aggregation and migration of cells that cause late cataracts.

One embodiment of the present invention is to provide an intraocular lens that inhibits cell proliferation, clustering, and mobility and controls the direction of cell movement by alternately or repeatedly disposing a plurality of pattern portions having irregularities of different sizes. do.

It is an object of the present invention to provide an intraocular lens in which a surface roughness having a complex dimension of micro- and nano-units is formed on the surface of a pattern part to more effectively prevent cell movement, proliferation, and aggregation.

A formulation comprising: an optic unit serving as a lens of the intraocular lens; and a haptic unit extending from the optic unit and serving to support the position of the optic unit; At least one of the first pattern portion including the first concave portion or the first convex portion and the second concave portion or the second pattern portion including the second convex portion formed with the fine concavo-convex portion are alternately or repeatedly positioned, the first concave portion, the At least one of the first convex portion, the second concave portion, and the second convex portion is provided with an intraocular lens having a different size.

Also, the width of the second recess may be wider than that of the first recess.

In addition, as the distance from the center of the optic part increases, the first pattern part (hereinafter, referred to as an 'inner first pattern part') that is closer to the optic part is repeatedly positioned, and then the second pattern part is positioned, and the second pattern part is positioned. The first pattern part (hereinafter, referred to as an 'outer first pattern part') may be repeatedly positioned outside the second pattern part.

In addition, the inner first pattern portion and the second pattern portion may be formed in the optic portion.

In addition, the inner first pattern portion, the second pattern portion, and the outer first pattern portion may be formed in the haptic portion.

In addition, the second pattern part may be formed in a connection portion of the optic part and the haptic part.

In addition, the outer first pattern portion may be formed at a connection portion of the optic portion and the haptic portion.

In addition, located on the outside of the outer first pattern portion with respect to the center of the optic portion, different from the sizes of the first pattern portion and the second pattern portion, and comprising a third concave portion and a third convex portion having the fine concavo-convex portion At least one third pattern portion may be alternately positioned with the outer first pattern portion.

In addition, the first pattern portion and the second pattern portion are alternately positioned with respect to the center of the optic portion, and the size of the first pattern portion relatively close to the center of the optic portion is relatively greater than the first pattern portion from the center of the optic portion. The size of the second pattern portion spaced apart from the pattern portion may be smaller than that of the pattern portion.

Also, the width of the first convex portion and the width of the second convex portion may be the same.

In addition, the height of the first convex portion and the second convex portion, and the depth of the first concave portion and the second concave portion may be formed to have the same size.

In addition, the height of the first convex portion, the second convex portion, and the depth of the first concave portion and the second concave portion may be formed to have different sizes.

In addition, the width R1 of the first convex portion is 5 μm, the width G1 of the first recess is 10 μm, the width R2 of the second convex portion is 5 μm, and the width of the second recess is (G2) may be 20 μm or more or 30 μm or more.

In addition, the width R1 of the first convex portion is 10 μm, the width G1 of the first recess is 10 μm, the width R2 of the second convex portion is 10 μm, and the width of the second recess is 10 μm (G2) may be 20 μm or more or 30 μm or more.

In addition, the fine concavo-convex part may be formed on the surfaces of the first pattern part, the second pattern part, and the third pattern part in micrometers or nanometers to have a surface roughness of the micrometers or nanometers. have.

In addition, the fine concavo-convex portion is provided as a microphone unit concavo-convex formed on a part of the surface of the first pattern unit, is provided as a nanometer unit concavo-convex unit formed on the remaining portion of the surface of the first pattern unit, and the second pattern unit It may be provided as a nanometer-scale concavo-convex portion formed on the surface.

In addition, a width ratio of the first convex portion and the first concave portion is in the range of 1:2 to 1:8, and the width ratio of the second convex portion and the second concave portion is in the range of 1:2 to 1:8. can be formed in

An embodiment of the present invention prevents the recurrence of eye diseases such as late-onset cataract by alternately disposing a plurality of pattern parts having irregularities of different sizes to inhibit cell proliferation, clustering, and mobility, and to control the direction of cell migration An intraocular lens can be provided.

An embodiment of the present invention may provide an intraocular lens in which a surface roughness having a complex dimension of micro and nano units is formed on the surface of a pattern part to more effectively prevent cell movement, proliferation, and aggregation.

1 is a view showing an artificial lens according to an embodiment of the present invention,

Figure 2 is a cross-sectional view showing an embodiment of part A of Figure 1,

3 is a diagram illustrating the surface roughness of a degree unit formed in a recess positioned in a first pattern portion or a second pattern portion in the intraocular lens according to an embodiment of the present invention;

4 is a cross-sectional schematic view for explaining the positions of the first pattern part and the second pattern part according to an embodiment of the present invention;

5a and 5b are variants of the depth and height of FIG. 4,

Figures 6a to 6c is a position modification of Figure 4,

7 is a schematic cross-sectional view for explaining the positions of the first pattern part, the second pattern part, and the third pattern part according to another embodiment of the present invention.

Hereinafter, specific embodiments of the present invention will be described with reference to the drawings. However, this is merely an example, and the present invention is not limited thereto.

In the description of the present invention, if it is determined that the detailed description of the known technology related to the present invention may unnecessarily obscure the gist of the present invention, the detailed description thereof will be omitted. And, the terms to be described later are terms defined in consideration of functions in the present invention, which may vary according to intentions or customs of users and operators. Therefore, the definition should be made based on the content throughout this specification.

The technical spirit of the present invention is determined by the claims, and the following examples are only one means for efficiently explaining the technical spirit of the present invention to those of ordinary skill in the art to which the present invention belongs.

1A and 1B are views illustrating an intraocular lens according to an embodiment according to the present invention, and FIG. 2 is a cross-sectional view illustrating an embodiment of a portion A of FIG. 1A.

1A, 1B and 2 , the intraocular lens according to the present invention includes an optic unit 110 and a haptic unit 120 . The optic unit 110 and the haptic unit 120 are integrally formed, and may be interconnected through a connecting portion, which is a circumferential surface indicated by reference numeral 130 in FIG. 1 . Here, the circumferential surface indicated by reference numeral 130 may be included in the optic unit 110 or the haptic unit 130 .

In addition, the optic unit 110 and the haptic unit 120 may be provided with a first pattern unit (A) and a second pattern unit (B) for suppressing cell proliferation, aggregation, and movement. Also, in some cases, as shown in FIG. 1B , the first pattern part A and the second pattern part B may not be formed in the haptic part 120 .

The optic unit 110 serves as a lens of the intraocular lens and is formed in a circular shape, and the haptic unit 120 extends from the circumferential surface of the optic unit 110 formed in a circular shape and supports the position of the optic unit 110 . It will serve as a support

The optic part 110 and the haptic part 120 may be made of various materials having transparency, but preferably made of at least one of plastic, silicone, hydrogel, and acrylic, more preferably acrylic resin, polymethyl It is effective for the pattern of the present invention to form and function efficiently while implementing an excellent lens function (polyHEMA, PMMA, etc) made of a methacrylate resin. However, the materials of the optic unit 110 and the haptic unit 120 are not limited thereto, and both a hydrophilic biomaterial and a hydrophobic biomaterial may be used.

A plurality of haptic units 120 are positioned to be spaced apart from each other in the circumferential direction of the optic unit 110 to stably support the position of the optic unit 110 .

At least one first pattern part (A) and at least one second pattern part (B) may be alternately or repeatedly positioned on at least a portion of at least one of the optic part 110 and the haptic part 120 . In addition, at least one first pattern part A and at least one second pattern part B may be alternately or repeatedly positioned on the optic part 110 and the haptic part 120 .

The first pattern part (A) and the second pattern part (B) are located within a range partially extending from the outer periphery of the optic part 110 toward the center of the edge of the optic part 110 , the optic part 110 . It may be located on either side of both surfaces of the optic unit 110 or located on both sides of the optic unit 110, respectively. Furthermore, it may be located on the side of the optic unit 120 .

In addition, the first pattern part A and the second pattern part B are formed on the surface of the haptic part 120 , and may be positioned on either one of both surfaces or on both surfaces of the haptic part 120 . Furthermore, it may be located on the side of the haptic unit 120 .

In addition, the first pattern part A and the second pattern part B may be located on the outer peripheral surface of the optic part 110 and the outer peripheral surface of the haptic part 120 .

The first pattern portion A is a pattern including at least one of the first concave portion 21 and the first convex portion 11 , and the second pattern portion B includes the second concave portion 22 and the second convex portion ( 12) may be a pattern including at least any one of.

As an example, the first pattern portion A is a concave-convex pattern including at least one first concave portion 21 and at least one first convex portion 11 .

The width of the first concave portion 21 may be formed to be larger than the width of the first convex portion 11, and the width ratio of the first convex portion 11 and the first concave portion 21 is in the range of 1:2 to 1:8. can be formed in

As an example, the second pattern portion B is a concave-convex pattern including at least one second concave portion 22 and at least one second convex portion 12 .

The width of the second concave portion 22 is formed to be larger than the width of the second convex portion 12, and the width ratio of the second convex portion 12 and the second concave portion 22 is in the range of 1:2 to 1:8. can be

The first pattern portion A may be a pattern in which the first convex portion 11 and the first concave portion 21 are continuously repeated, and the second pattern portion B includes the second convex portion 12 and It may be a pattern in which the second concave portion 22 is continuously repeated.

The first pattern portion A and the second pattern portion B have different sizes in at least one of height, depth, width, and roughness.

The first recess 21 and the second recess 22 may have different sizes in at least one of the widths G1 and G2 and the depths D1 and D2, as shown in FIG. 2 , The first convex portion 11 and the second convex portion 12 may have different sizes in at least one of widths R1 and R2 and heights D1 and D2.

The first pattern portion (A) and the second pattern portion (B) have a first concave portion 21 and a second concave portion ( 22) or at least one of widths R1 and R2 and heights D1 and D2 includes a first convex portion 11 and a second convex portion 12 having different sizes.

In addition, the first pattern portion (A) and the second pattern portion (B) are alternately positioned to prevent foreign substances, that is, ocular epithelial cells from moving or growing toward the center of the optic portion 110 , instead of the optic portion 110 . ) to move or grow to the outside (outer periphery side).

The first pattern part A and the second pattern part B are alternately positioned in the radial direction with respect to the center of the optic part 110 , and the first pattern part A close to the center of the optic part 110 . ), the size of the second pattern portion B farther from the center of the optic portion 110 may be larger than that of the first pattern portion A.

A first pattern part (A) and a second pattern part (B) may be positioned with respect to the center of the optic part 110 , and the first pattern part (A), the second pattern part (B), and the first pattern part The portion (A) may be continuously positioned, and the first pattern portion (A), the second pattern portion (B), the first pattern portion (A), and the second pattern portion (B) may be continuously positioned .

The width R1 of the first convex portion 11 and the width R2 of the second convex portion 12 are the same, and the width G1 of the first concave portion 21 and the width G2 of the second concave portion 22 have different sizes, the width G2 of the second concave portion 22 may be wider than the width G1 of the first concave portion 21 . That is, the width G1 of the first concave portion 21 may be narrower than the width G2 of the second concave portion 22 .

In addition, the height D1 of the first convex portion 11 , the height D2 of the second convex portion 12 , the depth D1 of the first concave portion 21 and the depth D2 of the second concave portion 22 are Formed in the same size as an example.

For example, the width R1 of the first convex portion 11 is 3 to 7 μm, the width G1 of the first recess 21 is 5 to 15 μm, and the width R2 of the second convex portion 12 is ) is 3 ~ 7㎛, the width (G2) of the second concave portion 22 may be 16 ~ 35㎛.

In more detail, the width R1 of the first convex portion 11 is 5 μm, the width G1 of the first recess 21 is 10 μm, and the width R2 of the second convex portion 12 is 5 μm, , the width G2 of the second recess 22 may be 20 μm or more or 30 μm or more. However, the present invention is not necessarily limited thereto, and the width R1 of the first convex portion 11 and the width R2 of the second convex portion 12 may be 10 μm.

As the width (G1) of the first recess (21) and the width (G2) of the second recess (22) increase in the width direction within the above range, the cell increases the expression of the protein for attachment, and as a result, the cell As the mobility increases and becomes narrower, the expression of the protein for adhesion is suppressed, and the mobility of cells may be reduced. However, when the recess is formed with a width less than the cell size in consideration of the cell size, or when the surface of the recess has a roughness of 200 nm or less, the expression of cell adhesion protein and the interaction between cells and cells are activated. It is possible to induce the formation of a colony and increase the movement speed of the cell population, and the width G1 of the first recess 21 in the first pattern portion A and the second pattern portion B alternately repeated with each other is When the width (G2) of the second recess 22 is 20 μm or more or 30 μm or more, the expression of cell adhesion protein and the cells attached to the first pattern part (A) and the second pattern part (B) are By inhibiting the interaction between cells, the movement speed of cells can be greatly reduced.

In the present invention, the first pattern portion (A) and the second pattern portion (B) are alternately positioned, the width of the first concave portion 21 is located narrower than the width of the second concave portion 22, so that the haptic portion 120 Inducing cell-cell interaction so that the cells that have moved from the to the optic unit 110 are moved again in a direction away from the center of the optic unit 110, or cells that have moved or crossed from the first pattern unit (A) are removed. By sticking in the 2 pattern part (B), it is possible to suppress the movement to the optic part (110).

In addition, the first recessed part 21 and the first convex part 11 and the second recessed part 22 and the second convex part 12 are formed in a closed curved shape or a closed loop shape to form the first recessed part 21 or the second recessed part 21 or the second recessed part. The lumen 22 is filled with as many cataract-causing cells as possible, and the cataract-inducing cells grow and proliferate along the first lumen 21 or the second lumen 22 to proliferate in the first lumen 21 . ) or the second recessed part 22, and then inserted into the next first recessed part 21 or the second recessed part 22 beyond the first convex part 11 or the second convex part 12 to be filled, thereby preventing cataracts. It minimizes the growth, proliferation and spread of the induced cells, thereby reflexively slowing the rate as much as possible.

However, the first concave portion 21 and the first convex portion 11 and the second concave portion 22 and the second convex portion 12 are not limited to being formed in a closed curve shape or in a closed loop shape.

The intraocular lens according to the present invention removes a cloudy lens from a cataract patient, is implanted in the human body to replace the removed lens, and can become cloudy again by a small amount of cells causing late-onset cataract remaining in the human body after transplantation. , it may be necessary to minimize and prevent cataract-causing cells from moving or proliferating inward of the optic unit 110 and falling over to the inside of the optic unit 110 .

That is, the first pattern part (A) and the second pattern part (B) are located near the outer periphery of the optic part 110 , that is, near the boundary between the optic part 110 and the haptic part 120 . is moved or proliferated inward of the optic unit 110 and prevents the cataract-causing cells from passing inside the optic unit 110 in the outward direction of the optic unit 110 , that is, from the center of the optic unit 110 . By inducing the movement of cataract-causing cells in a distant direction and cell-cell interaction, the cataract-causing cells proliferate and form a cluster, thereby preventing the occurrence of late-onset cataracts that cover the optic unit 110 .

On the other hand, the first pattern portion (A) and the second pattern portion (B) include micrometer or nanometer unit irregularities (hereinafter, abbreviated as 'fine irregularities') formed on the surface, whereby The first pattern portion A and the second pattern portion B may have a surface roughness of a micrometer unit or a nanometer unit.

Surface roughness by micro-scale irregularities and nano-scale irregularities is formed on the surface of the first pattern part A, that is, on the surfaces of the first convex part 11 and the first concave part 21, and the second pattern part The surface of (B) is formed with a surface roughness due to the concave-convex portion in the nanometer unit to limit the attachment and proliferation of cataract-causing cells, thereby slowing the movement toward the center of the optic unit 110 as much as possible.

That is, a portion of the surface of the first pattern portion (A) has an uneven portion in micrometer units, the remaining portion of the surface of the first pattern portion (A) has an uneven portion in a nanometer unit, and the second pattern portion (B) Concave-convex portions in nanometer units may be positioned on the surface of the .

In more detail, FIG. 3 is a diagram illustrating the surface roughness in nano units formed in recesses positioned in the first pattern part (A) or the second pattern part (B) in the intraocular lens according to an embodiment of the present invention. .

This indicates that a nanometer-scale structure is formed on the surface of the first recessed part 21 or the second recessed part 22 , and may be in a state in which the

processing protrusions

510 and 520 are provided.

The processing protrusions 510 and 520 may be formed in micrometer units to nanometer units, and may be formed in a structure for delaying or inhibiting cell adhesion, proliferation, and movement. For example, the nanometer-

scale processing protrusions

510 and 520 are formed to extend vertically upward, downward, horizontally, in an upper oblique direction or in a lower oblique direction from the surface of the first concave portion 21 or the second concave portion 22 . can be In addition, although not shown in the drawings of the present invention, the cross-sectional shape of the first recessed part 21 or the second recessed part 22 may be formed in a 'U' shape, and similarly, the processing protrusions 510 in nanometer units, 520 may be formed to extend vertically upwardly, downwardly, horizontally, upwardly diagonally, or downwardly diagonally from the surface of the first recessed part 21 or the second recessed part 22 .

In addition, the sizes (height, width, and spacing) of the

processing protrusions

510 and 520 may be formed in a range between 0.01 μm and 10 μm. When the surface roughness of the

processing protrusions

510 and 520 is formed with a size of 0.2 μm or more, cell adhesion is inhibited and the number of cells tends to decrease. After 24 hours, the cells become elongated in order to adhere to a stable surface. If the processing projections (510, 520) have a size of less than 0.1 μm or more than 10 μm, they do not have a significant effect on cell adhesion and thus the inhibitory power against cell mobility is reduced. deterrence may increase. In particular, when the

processing protrusions

510 and 520 have a size in the range of 0.1 to 0.2 μm, they are stably attached to the surface of the intraocular lens to prevent cataract-causing cells moving through the posterior capsule from moving to the optic unit 110 to improve mobility. effective in suppressing

In addition, the width w of the

processing protrusions

510 and 520 may be formed in a range between 0.1 μm and 10 μm. When the protrusion width (w) is formed to be less than 0.1 μm, the height that can be extended from the surface of the first recessed part 21 or the second recessed part 22 is shortened, making it difficult to perform the function of inhibiting cell movement. , when the projection width (w) exceeds 10㎛, the number of processing projections 520 that can be provided in the processing groove is reduced, it may be difficult to secure the coupling force. Accordingly, the protrusion width w may be formed in a range between 0.1 μm and 10 μm.

A laser is irradiated in the laser irradiation direction L, and a processing groove may be formed in the intraocular lens 100 . As the recessed

portions

21 and 22 are formed,

convex portions

11 and 12 may be formed on both sides. That is, the recessed

portions

21 and 22 formed by opening between the adjacent

convex portions

11 and 12 may be formed to have predetermined depths D1 and D2. The recessed

portions

21 and 22 may be further formed with finely processed

protrusions

510 and 520 and recessed

portions

21 and 22, which will be described later through the drawings to be more intuitively revealed in the following drawings.

Meanwhile, as the laser is irradiated in the laser irradiation direction L, recesses 21 and 22 may be formed in the intraocular lens 100 .

Therefore, the first concave portion 21 or the second concave portion 22 may be formed in an intaglio shape by a predetermined depth, which may be formed in a shape such as a groove, a non-through hole, and a drain.

Here, the predetermined depth may be determined according to the laser irradiation condition and the material of the intraocular lens 100 . For example, the laser irradiation conditions may include the output of the laser, the frequency of the laser, the irradiation time of the laser, the spot size of the laser, the processing speed, and the like.

Specifically, when the laser is irradiated to the intraocular lens 100 to form the first recessed part 21 or the second recessed part 22 by the predetermined depth, the processing groove of the target depth is formed by one irradiation. may not be formed. That is, as the output of the laser is higher, the predetermined depth can be formed in a shorter time. Of course, when processing is performed through a small number of irradiation with a high-power laser, thermal deformation may occur depending on the material of the intraocular lens 100, and the possibility that the intraocular lens 100 may be damaged by the laser may increase. have. In addition, the surface of the first recessed part 21 or the second recessed part 22 processed by the high-power laser is the first recessed part 21 or the second recessed part 22 processed multiple times by the low-power laser. The roughness may be greater than the surface of the

Here, the processing by laser irradiation two or more times means a depth that can be formed by one laser irradiation, and for this purpose, an area to which the laser is irradiated to the first object 100 may overlap. A method of irradiating the first object 100 so that the laser is overlapped may be a method of irradiating two or more laser beams to a portion of the first object 100 at a time interval or a distance interval. On the other hand, the ratio at which the lasers overlap may be referred to as an overlap ratio.

The spot size, frequency, scan interval, and scan speed of the irradiated laser may be factors determining the overlapping rate of the laser, and the predetermined depth may be determined by the overlapping rate. For example, the shorter the frequency period and the faster the scan speed, the lower the overlap rate may be. Conversely, as the frequency period is long and the scan speed is slow, the overlapping rate may be increased. Here, when the overlap rate is high, the specific gravity applied to the amount of energy emitted from the laser per unit area increases, so that the predetermined depth can be reached by selectively determining the laser frequency and scan speed.

In addition, the predetermined depth can be reached even in the case of repeated processing under the above laser conditions.

Accordingly, the depth of the first recess 21 or the second recess 22 formed by laser irradiation depends on the material of the intraocular lens 100 , the laser output, the laser frequency, the laser spot size, the scan interval, and the scan speed. , is a factor that can be selectively determined in consideration of conditions such as the number of repeated processing, which can be determined according to the above-described conditions even for the first recessed part 21 or the second recessed part 22 and the processing protrusion 520 described in the present invention. have.

4 is a cross-sectional schematic view for explaining the positions of the first pattern part and the second pattern part according to an embodiment of the present invention, FIGS. 5A and 5B are depth and height modifications of FIG. 4 , and FIGS. 6A to 6C is a position modification of FIG. 4 , and FIG. 7 is a schematic cross-sectional view for explaining the positions of the first pattern part, the second pattern part, and the third pattern part according to another embodiment of the present invention.

In one embodiment of the present invention, as shown in FIG. 4 , at least one or more first pattern portions A and A-1 having fine concavo-convex portions formed on the surface are repeated in a direction away from the center of the optic portion 110 . After being disposed, at least one second pattern portion (B) having a fine concavo-convex portion formed on the surface is repeatedly positioned outside the first pattern portion (A, A-1), and then again the first pattern portion (A, At least one of A-2) may be repeatedly positioned to the outside of the second pattern part (B).

Hereinafter, the first pattern part (A) positioned closer to the optic part 110 as compared to the second pattern part (B) of the first pattern part (A) is defined as an 'inner first pattern part' and , the reference numeral 'A-2' is indicated to be described separately from the 'outer first pattern part (A-2)' provided on the outside of the second pattern part (B).

As such, in one embodiment of the present invention, the inner first pattern portion (A-1), the second pattern portion (B), and the outer first pattern portion (A-2) in a direction away from the center of the optic portion (110) By being positioned to repeat or alternate with each other, it presents an optimal structure that inhibits cell migration.

In addition, in one embodiment of the present invention, as shown in Fig. 5a, the first of the inner first pattern portion (A-1), the second pattern portion (B), and the outer first pattern portion (A-2) (A-2) The height D1 of the convex portion 11, the height D2 of the second convex portion 12, the depth D1 of the first concave portion 21, and the depth D2 of the second concave portion 22 are all the same size. may be formed. Alternatively, as shown in FIG. 5B , the height D2 of the second pattern part B, the depth D1 of the first recess 21 and the depth D2 of the second recess 22 are the outer first patterns. The height D1 of the first convex portion 11 of the portion A-2 and/or the inner first pattern portion A-1, the height D2 of the second convex portion 12, and the first concave portion 21 It may be formed to be lower than the depth D1 and the depth D2 of the second recess 22 .

Here, as shown in FIG. 6A , the inner first pattern part A-1 and the second pattern part B may be formed to be positioned on the optic part 110 . However, the outer first pattern portion A-2 may be located in the optic unit 110 or may be located only in the haptic unit 120 .

In addition, as shown in FIG. 6B , the inner first pattern portion A-1, the second pattern portion B, and the outer first pattern portion A-2 are formed to be positioned on the haptic portion 120 . can be

However, the first pattern portion (A) and the second pattern portion (B) do not necessarily have to be uniformly positioned as described above, and as shown in FIG. 6C , the inner first pattern portion (A-1) and The position order of the second pattern part B and the outer first pattern part A-2 is fixed, but the second pattern part B is connected to the optic part 110 and the haptic part 120 in the connection part 130 It is also possible to be formed to be located in the.

On the other hand, the above-described embodiment of the present invention includes only the first pattern portion (A) and the second pattern portion (B), but as shown in FIG. At least one third pattern portion (C) including a convex portion may be further included.

The third pattern portion (C) may be provided to have a size different from that of the first pattern portion (A) and the second pattern portion (B). Preferably, the third pattern portion (C) has a greater width than the first concave portion 11 of the first pattern portion (A), and has a width greater than that of the second concave portion 21 of the second pattern portion (B). This can have the size of a small intermediate region.

As shown in FIG. 7 , the third pattern portion C may be alternately or repeatedly positioned with the outer first pattern portion A-2.

An embodiment of the present invention includes a pattern portion having an uneven portion in nanometer units to inhibit cell adhesion and proliferation and cell mobility due to an increase in surface roughness to prevent recurrence of eye diseases such as late-onset cataract.

According to an embodiment of the present invention, a surface roughness having a complex dimension of micro and nano units is formed on the surface of the pattern part to more effectively prevent cell movement, proliferation, and aggregation.

Although representative embodiments of the present invention have been described in detail above, those of ordinary skill in the art to which the present invention pertains will understand that various modifications are possible without departing from the scope of the present invention with respect to the above-described embodiments. . Therefore, the scope of the present invention should not be limited to the described embodiments, but should be defined by the claims described below as well as the claims and equivalents.

Claims

an optic unit serving as a lens of the intraocular lens; and

and a haptic part extending from the optic part and serving to support the position of the optic part;

On at least one side of the optic part and the haptic part, a first pattern portion including a first concave portion or a first convex portion having a fine concavo-convex portion formed on a surface thereof, and a second pattern including a second concave portion or a second convex portion formed with a fine concavo-convex portion At least one of the parts is alternately or repeatedly positioned, and at least one of the first recessed part, the first convex part, the second recessed part, and the second convex part has a different size.
The method according to claim 1,

wherein the width of the second recess is wider than that of the first recess.
3. The method according to claim 2,

As the distance from the center of the optic part increases, the first pattern part (hereinafter, referred to as an 'inner first pattern part') close to the optic part is repeatedly positioned, and then the second pattern part is positioned, and the second pattern part is positioned. The first pattern portion (hereinafter, referred to as 'outer first pattern portion') is repeatedly positioned outside the portion, the intraocular lens.
4. The method according to claim 3,

The inner first pattern portion and the second pattern portion are formed in the optic portion, the intraocular lens.
4. The method according to claim 3,

The inner first pattern portion, the second pattern portion, and the outer first pattern portion are formed in the haptic portion.
4. The method according to claim 3,

The second pattern portion is formed in a connection portion of the optic portion and the haptic portion, the intraocular lens.
4. The method according to claim 3,

The outer first pattern portion is formed in a connection portion of the optic portion and the haptic portion, the intraocular lens.
4. The method according to claim 3,

At least one of which is located outside the outer first pattern portion with respect to the center of the optic portion, is different from the sizes of the first pattern portion and the second pattern portion, and includes a third concave portion and a third convex portion having the minute concavo-convex portion The third pattern portion of the intraocular lens is positioned alternately with the outer first pattern portion.
The method according to claim 1,

The first pattern part and the second pattern part are alternately positioned with respect to the center of the optic part,

wherein a size of the first pattern portion relatively close to the center of the optic portion is smaller than a size of the second pattern portion more spaced apart from the center of the optic portion than the first pattern portion.
The method according to claim 1,

and the width of the first convex portion and the width of the second convex portion are formed to be the same.
11. The method of claim 10,

The first convex portion, the height of the second convex portion, and the depth of the first concave portion and the second concave portion are formed to have the same size.
11. The method of claim 10,

The first convex portion, the height of the second convex portion, and the depth of the first concave portion and the second concave portion are formed to have different sizes.
The method according to claim 1,

The width (R1) of the first convex portion is 5㎛, the width (G1) of the first concave portion is 10㎛,

A width R2 of the second convex portion is 5 μm, and a width G2 of the second recess is 20 μm or more or 30 μm or more.
The method according to claim 1,

The width (R1) of the first convex portion is 10㎛, the width (G1) of the first concave portion is 10㎛,

A width R2 of the second convex portion is 10 μm, and a width G2 of the second recess is 20 μm or more or 30 μm or more.
The method according to claim 1,

The fine concavo-convex part is formed on the surfaces of the first pattern part, the second pattern part, and the third pattern part in micrometers or nanometers, and has a surface roughness in micrometers or nanometers. .
16. The method of claim 15,

The fine concavo-convex portion,

It is provided as a microphone unit concave-convex portion formed on a part of the surface of the first pattern unit, and is provided as a nanometer unit concavo-convex unit formed on the remaining part of the surface of the first pattern unit,

The intraocular lens is provided as a nanometer-scale uneven portion formed on the surface of the second pattern portion.
The method according to claim 1,

The width ratio of the first convex portion and the first concave portion is formed within the range of 1:2 to 1:8,

The second convex portion and the width ratio of the second recessed portion are formed within the range of 1:2 to 1:8, the intraocular lens.
The method according to claim 1,

The recessed portion comprises a boundary portion that delays or blocks the movement of cells, the intraocular lens.
19. The method of claim 18,

The boundary portion forms a plurality of cell passageways within the width of the recess to apply a change to the movement speed of the cells.
20. The method of claim 19,

The boundary portion extends diagonally inward from the sidewall of the recess, narrowing the cross-sectional area of passage of the cells in the forward direction in which the cells move and blocking the movement of the cells in the reverse direction to guide the movement direction of the cells. lens.
19. The method of claim 18,

The boundary portion is formed so as to protrude upward from the bottom of the recess, and extends in an oblique direction to bypass and block movement of the cells in the forward direction in which the cells move, and to increase the passage cross-sectional area in the reverse direction. lens.