WO2021246799A1 - Lentille intraoculaire - Google Patents

Lentille intraoculaire Download PDF

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Publication number
WO2021246799A1
WO2021246799A1 PCT/KR2021/006932 KR2021006932W WO2021246799A1 WO 2021246799 A1 WO2021246799 A1 WO 2021246799A1 KR 2021006932 W KR2021006932 W KR 2021006932W WO 2021246799 A1 WO2021246799 A1 WO 2021246799A1
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Prior art keywords
pattern
optic
width
convex
convex portion
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PCT/KR2021/006932
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English (en)
Korean (ko)
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최병찬
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최병찬
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Publication of WO2021246799A1 publication Critical patent/WO2021246799A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/14—Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
    • A61F2/16—Intraocular lenses
    • A61F2/1613—Intraocular lenses having special lens configurations, e.g. multipart lenses; having particular optical properties, e.g. pseudo-accommodative lenses, lenses having aberration corrections, diffractive lenses, lenses for variably absorbing electromagnetic radiation, lenses having variable focus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/0077—Special surfaces of prostheses, e.g. for improving ingrowth
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/14—Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
    • A61F2/16—Intraocular lenses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/0077—Special surfaces of prostheses, e.g. for improving ingrowth
    • A61F2002/0081—Special surfaces of prostheses, e.g. for improving ingrowth directly machined on the prosthetic surface, e.g. holes, grooves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/0077—Special surfaces of prostheses, e.g. for improving ingrowth
    • A61F2002/009—Special surfaces of prostheses, e.g. for improving ingrowth for hindering or preventing attachment of biological tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/14—Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
    • A61F2/16—Intraocular lenses
    • A61F2002/1681—Intraocular lenses having supporting structure for lens, e.g. haptics

Definitions

  • the present invention relates to an intraocular lens.
  • the human eye is similar to the structure and function of a camera.
  • a crystalline lens made of transparent tissue in the shape of a convex lens, which functions as a camera lens. Cataract is induced when the lens becomes cloudy due to external damage or use of unnecessary eye drops, radiation exposure, and exposure to various harmful electromagnetic waves.
  • One of the surgical methods for the treatment of such cataracts is a method of implanting an artificial lens that can replace the function of the lens.
  • the intraocular lens is operated so as to be inserted into a portion called a capsuleer bag in the eye or between the capsuleer bag and the iris.
  • the turbidity reoccurs due to the proliferation, clustering, and movement of the cells that cause late-onset cataracts.
  • One embodiment of the present invention is to provide an intraocular lens that inhibits cell proliferation, clustering, and mobility and controls the direction of cell movement by alternately or repeatedly disposing a plurality of pattern portions having irregularities of different sizes. do.
  • a formulation comprising: an optic unit serving as a lens of the intraocular lens; and a haptic unit extending from the optic unit and serving to support the position of the optic unit; At least one of the first pattern portion including the first concave portion or the first convex portion and the second concave portion or the second pattern portion including the second convex portion formed with the fine concavo-convex portion are alternately or repeatedly positioned, the first concave portion, the At least one of the first convex portion, the second concave portion, and the second convex portion is provided with an intraocular lens having a different size.
  • the width of the second recess may be wider than that of the first recess.
  • the first pattern part (hereinafter, referred to as an 'inner first pattern part') that is closer to the optic part is repeatedly positioned, and then the second pattern part is positioned, and the second pattern part is positioned.
  • the first pattern part (hereinafter, referred to as an 'outer first pattern part') may be repeatedly positioned outside the second pattern part.
  • the inner first pattern portion and the second pattern portion may be formed in the optic portion.
  • the inner first pattern portion, the second pattern portion, and the outer first pattern portion may be formed in the haptic portion.
  • the second pattern part may be formed in a connection portion of the optic part and the haptic part.
  • the outer first pattern portion may be formed at a connection portion of the optic portion and the haptic portion.
  • At least one third pattern portion may be alternately positioned with the outer first pattern portion.
  • first pattern portion and the second pattern portion are alternately positioned with respect to the center of the optic portion, and the size of the first pattern portion relatively close to the center of the optic portion is relatively greater than the first pattern portion from the center of the optic portion.
  • the size of the second pattern portion spaced apart from the pattern portion may be smaller than that of the pattern portion.
  • the width of the second recess may be wider than that of the first recess.
  • the width of the first convex portion and the width of the second convex portion may be the same.
  • the height of the first convex portion and the second convex portion, and the depth of the first concave portion and the second concave portion may be formed to have the same size.
  • the height of the first convex portion, the second convex portion, and the depth of the first concave portion and the second concave portion may be formed to have different sizes.
  • the width R1 of the first convex portion is 5 ⁇ m
  • the width G1 of the first recess is 10 ⁇ m
  • the width R2 of the second convex portion is 5 ⁇ m
  • the width of the second recess is (G2) may be 20 ⁇ m or more or 30 ⁇ m or more.
  • the width R1 of the first convex portion is 10 ⁇ m
  • the width G1 of the first recess is 10 ⁇ m
  • the width R2 of the second convex portion is 10 ⁇ m
  • the width of the second recess is 10 ⁇ m (G2) may be 20 ⁇ m or more or 30 ⁇ m or more.
  • the fine concavo-convex part may be formed on the surfaces of the first pattern part, the second pattern part, and the third pattern part in micrometers or nanometers to have a surface roughness of the micrometers or nanometers. have.
  • the fine concavo-convex portion is provided as a microphone unit concavo-convex formed on a part of the surface of the first pattern unit, is provided as a nanometer unit concavo-convex unit formed on the remaining portion of the surface of the first pattern unit, and the second pattern unit It may be provided as a nanometer-scale concavo-convex portion formed on the surface.
  • a width ratio of the first convex portion and the first concave portion is in the range of 1:2 to 1:8, and the width ratio of the second convex portion and the second concave portion is in the range of 1:2 to 1:8.
  • An embodiment of the present invention prevents the recurrence of eye diseases such as late-onset cataract by alternately disposing a plurality of pattern parts having irregularities of different sizes to inhibit cell proliferation, clustering, and mobility, and to control the direction of cell migration
  • An intraocular lens can be provided.
  • An embodiment of the present invention may provide an intraocular lens in which a surface roughness having a complex dimension of micro and nano units is formed on the surface of a pattern part to more effectively prevent cell movement, proliferation, and aggregation.
  • FIG. 1 is a view showing an artificial lens according to an embodiment of the present invention
  • Figure 2 is a cross-sectional view showing an embodiment of part A of Figure 1,
  • FIG. 3 is a diagram illustrating the surface roughness of a degree unit formed in a recess positioned in a first pattern portion or a second pattern portion in the intraocular lens according to an embodiment of the present invention
  • FIG. 4 is a cross-sectional schematic view for explaining the positions of the first pattern part and the second pattern part according to an embodiment of the present invention
  • 5a and 5b are variants of the depth and height of FIG. 4,
  • Figures 6a to 6c is a position modification of Figure 4,
  • FIG. 7 is a schematic cross-sectional view for explaining the positions of the first pattern part, the second pattern part, and the third pattern part according to another embodiment of the present invention.
  • FIG. 1A and 1B are views illustrating an intraocular lens according to an embodiment according to the present invention
  • FIG. 2 is a cross-sectional view illustrating an embodiment of a portion A of FIG. 1A.
  • the intraocular lens according to the present invention includes an optic unit 110 and a haptic unit 120 .
  • the optic unit 110 and the haptic unit 120 are integrally formed, and may be interconnected through a connecting portion, which is a circumferential surface indicated by reference numeral 130 in FIG. 1 .
  • the circumferential surface indicated by reference numeral 130 may be included in the optic unit 110 or the haptic unit 130 .
  • the optic unit 110 and the haptic unit 120 may be provided with a first pattern unit (A) and a second pattern unit (B) for suppressing cell proliferation, aggregation, and movement. Also, in some cases, as shown in FIG. 1B , the first pattern part A and the second pattern part B may not be formed in the haptic part 120 .
  • the optic unit 110 serves as a lens of the intraocular lens and is formed in a circular shape, and the haptic unit 120 extends from the circumferential surface of the optic unit 110 formed in a circular shape and supports the position of the optic unit 110 . It will serve as a support
  • the optic part 110 and the haptic part 120 may be made of various materials having transparency, but preferably made of at least one of plastic, silicone, hydrogel, and acrylic, more preferably acrylic resin, polymethyl It is effective for the pattern of the present invention to form and function efficiently while implementing an excellent lens function (polyHEMA, PMMA, etc) made of a methacrylate resin.
  • the materials of the optic unit 110 and the haptic unit 120 are not limited thereto, and both a hydrophilic biomaterial and a hydrophobic biomaterial may be used.
  • a plurality of haptic units 120 are positioned to be spaced apart from each other in the circumferential direction of the optic unit 110 to stably support the position of the optic unit 110 .
  • At least one first pattern part (A) and at least one second pattern part (B) may be alternately or repeatedly positioned on at least a portion of at least one of the optic part 110 and the haptic part 120 .
  • at least one first pattern part A and at least one second pattern part B may be alternately or repeatedly positioned on the optic part 110 and the haptic part 120 .
  • the first pattern part (A) and the second pattern part (B) are located within a range partially extending from the outer periphery of the optic part 110 toward the center of the edge of the optic part 110 , the optic part 110 . It may be located on either side of both surfaces of the optic unit 110 or located on both sides of the optic unit 110, respectively. Furthermore, it may be located on the side of the optic unit 120 .
  • first pattern part A and the second pattern part B are formed on the surface of the haptic part 120 , and may be positioned on either one of both surfaces or on both surfaces of the haptic part 120 . Furthermore, it may be located on the side of the haptic unit 120 .
  • first pattern part A and the second pattern part B may be located on the outer peripheral surface of the optic part 110 and the outer peripheral surface of the haptic part 120 .
  • the first pattern portion A is a pattern including at least one of the first concave portion 21 and the first convex portion 11
  • the second pattern portion B includes the second concave portion 22 and the second convex portion ( 12) may be a pattern including at least any one of.
  • the first pattern portion A is a concave-convex pattern including at least one first concave portion 21 and at least one first convex portion 11 .
  • the width of the first concave portion 21 may be formed to be larger than the width of the first convex portion 11, and the width ratio of the first convex portion 11 and the first concave portion 21 is in the range of 1:2 to 1:8. can be formed in
  • the second pattern portion B is a concave-convex pattern including at least one second concave portion 22 and at least one second convex portion 12 .
  • the width of the second concave portion 22 is formed to be larger than the width of the second convex portion 12, and the width ratio of the second convex portion 12 and the second concave portion 22 is in the range of 1:2 to 1:8. can be
  • the first pattern portion A may be a pattern in which the first convex portion 11 and the first concave portion 21 are continuously repeated
  • the second pattern portion B includes the second convex portion 12 and It may be a pattern in which the second concave portion 22 is continuously repeated.
  • the first pattern portion A and the second pattern portion B have different sizes in at least one of height, depth, width, and roughness.
  • the first recess 21 and the second recess 22 may have different sizes in at least one of the widths G1 and G2 and the depths D1 and D2, as shown in FIG. 2 ,
  • the first convex portion 11 and the second convex portion 12 may have different sizes in at least one of widths R1 and R2 and heights D1 and D2.
  • the first pattern portion (A) and the second pattern portion (B) have a first concave portion 21 and a second concave portion ( 22) or at least one of widths R1 and R2 and heights D1 and D2 includes a first convex portion 11 and a second convex portion 12 having different sizes.
  • first pattern portion (A) and the second pattern portion (B) are alternately positioned to prevent foreign substances, that is, ocular epithelial cells from moving or growing toward the center of the optic portion 110 , instead of the optic portion 110 . ) to move or grow to the outside (outer periphery side).
  • the first pattern part A and the second pattern part B are alternately positioned in the radial direction with respect to the center of the optic part 110 , and the first pattern part A close to the center of the optic part 110 . ), the size of the second pattern portion B farther from the center of the optic portion 110 may be larger than that of the first pattern portion A.
  • a first pattern part (A) and a second pattern part (B) may be positioned with respect to the center of the optic part 110 , and the first pattern part (A), the second pattern part (B), and the first pattern part
  • the portion (A) may be continuously positioned, and the first pattern portion (A), the second pattern portion (B), the first pattern portion (A), and the second pattern portion (B) may be continuously positioned .
  • the width R1 of the first convex portion 11 and the width R2 of the second convex portion 12 are the same, and the width G1 of the first concave portion 21 and the width G2 of the second concave portion 22 have different sizes, the width G2 of the second concave portion 22 may be wider than the width G1 of the first concave portion 21 . That is, the width G1 of the first concave portion 21 may be narrower than the width G2 of the second concave portion 22 .
  • the height D1 of the first convex portion 11 the height D2 of the second convex portion 12 , the depth D1 of the first concave portion 21 and the depth D2 of the second concave portion 22 are Formed in the same size as an example.
  • the width R1 of the first convex portion 11 is 3 to 7 ⁇ m
  • the width G1 of the first recess 21 is 5 to 15 ⁇ m
  • the width R2 of the second convex portion 12 is ) is 3 ⁇ 7 ⁇ m
  • the width (G2) of the second concave portion 22 may be 16 ⁇ 35 ⁇ m.
  • the width R1 of the first convex portion 11 is 5 ⁇ m
  • the width G1 of the first recess 21 is 10 ⁇ m
  • the width R2 of the second convex portion 12 is 5 ⁇ m
  • the width G2 of the second recess 22 may be 20 ⁇ m or more or 30 ⁇ m or more.
  • the present invention is not necessarily limited thereto, and the width R1 of the first convex portion 11 and the width R2 of the second convex portion 12 may be 10 ⁇ m.
  • the cell increases the expression of the protein for attachment, and as a result, the cell As the mobility increases and becomes narrower, the expression of the protein for adhesion is suppressed, and the mobility of cells may be reduced.
  • the recess is formed with a width less than the cell size in consideration of the cell size, or when the surface of the recess has a roughness of 200 nm or less, the expression of cell adhesion protein and the interaction between cells and cells are activated.
  • the width G1 of the first recess 21 in the first pattern portion A and the second pattern portion B alternately repeated with each other is
  • the width (G2) of the second recess 22 is 20 ⁇ m or more or 30 ⁇ m or more, the expression of cell adhesion protein and the cells attached to the first pattern part (A) and the second pattern part (B) are By inhibiting the interaction between cells, the movement speed of cells can be greatly reduced.
  • the first pattern portion (A) and the second pattern portion (B) are alternately positioned, the width of the first concave portion 21 is located narrower than the width of the second concave portion 22, so that the haptic portion 120 Inducing cell-cell interaction so that the cells that have moved from the to the optic unit 110 are moved again in a direction away from the center of the optic unit 110, or cells that have moved or crossed from the first pattern unit (A) are removed.
  • the 2 pattern part (B) it is possible to suppress the movement to the optic part (110).
  • first recessed part 21 and the first convex part 11 and the second recessed part 22 and the second convex part 12 are formed in a closed curved shape or a closed loop shape to form the first recessed part 21 or the second recessed part 21 or the second recessed part.
  • the lumen 22 is filled with as many cataract-causing cells as possible, and the cataract-inducing cells grow and proliferate along the first lumen 21 or the second lumen 22 to proliferate in the first lumen 21 . ) or the second recessed part 22, and then inserted into the next first recessed part 21 or the second recessed part 22 beyond the first convex part 11 or the second convex part 12 to be filled, thereby preventing cataracts. It minimizes the growth, proliferation and spread of the induced cells, thereby reflexively slowing the rate as much as possible.
  • first concave portion 21 and the first convex portion 11 and the second concave portion 22 and the second convex portion 12 are not limited to being formed in a closed curve shape or in a closed loop shape.
  • the intraocular lens according to the present invention removes a cloudy lens from a cataract patient, is implanted in the human body to replace the removed lens, and can become cloudy again by a small amount of cells causing late-onset cataract remaining in the human body after transplantation. , it may be necessary to minimize and prevent cataract-causing cells from moving or proliferating inward of the optic unit 110 and falling over to the inside of the optic unit 110 .
  • the first pattern part (A) and the second pattern part (B) are located near the outer periphery of the optic part 110 , that is, near the boundary between the optic part 110 and the haptic part 120 . is moved or proliferated inward of the optic unit 110 and prevents the cataract-causing cells from passing inside the optic unit 110 in the outward direction of the optic unit 110 , that is, from the center of the optic unit 110 .
  • the cataract-causing cells proliferate and form a cluster, thereby preventing the occurrence of late-onset cataracts that cover the optic unit 110 .
  • first pattern portion (A) and the second pattern portion (B) include micrometer or nanometer unit irregularities (hereinafter, abbreviated as 'fine irregularities') formed on the surface, whereby The first pattern portion A and the second pattern portion B may have a surface roughness of a micrometer unit or a nanometer unit.
  • the surface of (B) is formed with a surface roughness due to the concave-convex portion in the nanometer unit to limit the attachment and proliferation of cataract-causing cells, thereby slowing the movement toward the center of the optic unit 110 as much as possible.
  • a portion of the surface of the first pattern portion (A) has an uneven portion in micrometer units
  • the remaining portion of the surface of the first pattern portion (A) has an uneven portion in a nanometer unit
  • the second pattern portion (B) Concave-convex portions in nanometer units may be positioned on the surface of the .
  • FIG. 3 is a diagram illustrating the surface roughness in nano units formed in recesses positioned in the first pattern part (A) or the second pattern part (B) in the intraocular lens according to an embodiment of the present invention. .
  • a nanometer-scale structure is formed on the surface of the first recessed part 21 or the second recessed part 22 , and may be in a state in which the processing protrusions 510 and 520 are provided.
  • the processing protrusions 510 and 520 may be formed in micrometer units to nanometer units, and may be formed in a structure for delaying or inhibiting cell adhesion, proliferation, and movement.
  • the nanometer-scale processing protrusions 510 and 520 are formed to extend vertically upward, downward, horizontally, in an upper oblique direction or in a lower oblique direction from the surface of the first concave portion 21 or the second concave portion 22 .
  • the cross-sectional shape of the first recessed part 21 or the second recessed part 22 may be formed in a 'U' shape, and similarly, the processing protrusions 510 in nanometer units, 520 may be formed to extend vertically upwardly, downwardly, horizontally, upwardly diagonally, or downwardly diagonally from the surface of the first recessed part 21 or the second recessed part 22 .
  • the sizes (height, width, and spacing) of the processing protrusions 510 and 520 may be formed in a range between 0.01 ⁇ m and 10 ⁇ m.
  • the surface roughness of the processing protrusions 510 and 520 is formed with a size of 0.2 ⁇ m or more, cell adhesion is inhibited and the number of cells tends to decrease. After 24 hours, the cells become elongated in order to adhere to a stable surface. If the processing projections (510, 520) have a size of less than 0.1 ⁇ m or more than 10 ⁇ m, they do not have a significant effect on cell adhesion and thus the inhibitory power against cell mobility is reduced. deterrence may increase.
  • processing protrusions 510 and 520 have a size in the range of 0.1 to 0.2 ⁇ m, they are stably attached to the surface of the intraocular lens to prevent cataract-causing cells moving through the posterior capsule from moving to the optic unit 110 to improve mobility. effective in suppressing
  • the width w of the processing protrusions 510 and 520 may be formed in a range between 0.1 ⁇ m and 10 ⁇ m.
  • the protrusion width (w) is formed to be less than 0.1 ⁇ m, the height that can be extended from the surface of the first recessed part 21 or the second recessed part 22 is shortened, making it difficult to perform the function of inhibiting cell movement.
  • the projection width (w) exceeds 10 ⁇ m, the number of processing projections 520 that can be provided in the processing groove is reduced, it may be difficult to secure the coupling force. Accordingly, the protrusion width w may be formed in a range between 0.1 ⁇ m and 10 ⁇ m.
  • a laser is irradiated in the laser irradiation direction L, and a processing groove may be formed in the intraocular lens 100 .
  • convex portions 11 and 12 may be formed on both sides. That is, the recessed portions 21 and 22 formed by opening between the adjacent convex portions 11 and 12 may be formed to have predetermined depths D1 and D2.
  • the recessed portions 21 and 22 may be further formed with finely processed protrusions 510 and 520 and recessed portions 21 and 22, which will be described later through the drawings to be more intuitively revealed in the following drawings.
  • recesses 21 and 22 may be formed in the intraocular lens 100 .
  • the first concave portion 21 or the second concave portion 22 may be formed in an intaglio shape by a predetermined depth, which may be formed in a shape such as a groove, a non-through hole, and a drain.
  • the predetermined depth may be determined according to the laser irradiation condition and the material of the intraocular lens 100 .
  • the laser irradiation conditions may include the output of the laser, the frequency of the laser, the irradiation time of the laser, the spot size of the laser, the processing speed, and the like.
  • the processing groove of the target depth is formed by one irradiation. may not be formed. That is, as the output of the laser is higher, the predetermined depth can be formed in a shorter time.
  • thermal deformation may occur depending on the material of the intraocular lens 100, and the possibility that the intraocular lens 100 may be damaged by the laser may increase. have.
  • the surface of the first recessed part 21 or the second recessed part 22 processed by the high-power laser is the first recessed part 21 or the second recessed part 22 processed multiple times by the low-power laser. The roughness may be greater than the surface of the
  • the processing by laser irradiation two or more times means a depth that can be formed by one laser irradiation, and for this purpose, an area to which the laser is irradiated to the first object 100 may overlap.
  • a method of irradiating the first object 100 so that the laser is overlapped may be a method of irradiating two or more laser beams to a portion of the first object 100 at a time interval or a distance interval.
  • the ratio at which the lasers overlap may be referred to as an overlap ratio.
  • the spot size, frequency, scan interval, and scan speed of the irradiated laser may be factors determining the overlapping rate of the laser, and the predetermined depth may be determined by the overlapping rate. For example, the shorter the frequency period and the faster the scan speed, the lower the overlap rate may be. Conversely, as the frequency period is long and the scan speed is slow, the overlapping rate may be increased.
  • the overlap rate is high, the specific gravity applied to the amount of energy emitted from the laser per unit area increases, so that the predetermined depth can be reached by selectively determining the laser frequency and scan speed.
  • the predetermined depth can be reached even in the case of repeated processing under the above laser conditions.
  • the depth of the first recess 21 or the second recess 22 formed by laser irradiation depends on the material of the intraocular lens 100 , the laser output, the laser frequency, the laser spot size, the scan interval, and the scan speed. , is a factor that can be selectively determined in consideration of conditions such as the number of repeated processing, which can be determined according to the above-described conditions even for the first recessed part 21 or the second recessed part 22 and the processing protrusion 520 described in the present invention. have.
  • FIG. 4 is a cross-sectional schematic view for explaining the positions of the first pattern part and the second pattern part according to an embodiment of the present invention
  • FIGS. 5A and 5B are depth and height modifications of FIG. 4
  • FIGS. 6A to 6C is a position modification of FIG. 4
  • FIG. 7 is a schematic cross-sectional view for explaining the positions of the first pattern part, the second pattern part, and the third pattern part according to another embodiment of the present invention.
  • At least one or more first pattern portions A and A-1 having fine concavo-convex portions formed on the surface are repeated in a direction away from the center of the optic portion 110 .
  • at least one second pattern portion (B) having a fine concavo-convex portion formed on the surface is repeatedly positioned outside the first pattern portion (A, A-1), and then again the first pattern portion (A, At least one of A-2) may be repeatedly positioned to the outside of the second pattern part (B).
  • the first pattern part (A) positioned closer to the optic part 110 as compared to the second pattern part (B) of the first pattern part (A) is defined as an 'inner first pattern part' and , the reference numeral 'A-2' is indicated to be described separately from the 'outer first pattern part (A-2)' provided on the outside of the second pattern part (B).
  • the inner first pattern portion (A-1), the second pattern portion (B), and the outer first pattern portion (A-2) in a direction away from the center of the optic portion (110) By being positioned to repeat or alternate with each other, it presents an optimal structure that inhibits cell migration.
  • the first of the inner first pattern portion (A-1), the second pattern portion (B), and the outer first pattern portion (A-2) A-2)
  • the height D1 of the convex portion 11, the height D2 of the second convex portion 12, the depth D1 of the first concave portion 21, and the depth D2 of the second concave portion 22 are all the same size. may be formed.
  • the height D2 of the second pattern part B, the depth D1 of the first recess 21 and the depth D2 of the second recess 22 are the outer first patterns.
  • the height D1 of the first convex portion 11 of the portion A-2 and/or the inner first pattern portion A-1, the height D2 of the second convex portion 12, and the first concave portion 21 It may be formed to be lower than the depth D1 and the depth D2 of the second recess 22 .
  • the inner first pattern part A-1 and the second pattern part B may be formed to be positioned on the optic part 110 .
  • the outer first pattern portion A-2 may be located in the optic unit 110 or may be located only in the haptic unit 120 .
  • the inner first pattern portion A-1, the second pattern portion B, and the outer first pattern portion A-2 are formed to be positioned on the haptic portion 120 .
  • first pattern portion (A) and the second pattern portion (B) do not necessarily have to be uniformly positioned as described above, and as shown in FIG. 6C , the inner first pattern portion (A-1) and The position order of the second pattern part B and the outer first pattern part A-2 is fixed, but the second pattern part B is connected to the optic part 110 and the haptic part 120 in the connection part 130 It is also possible to be formed to be located in the.
  • the above-described embodiment of the present invention includes only the first pattern portion (A) and the second pattern portion (B), but as shown in FIG. At least one third pattern portion (C) including a convex portion may be further included.
  • the third pattern portion (C) may be provided to have a size different from that of the first pattern portion (A) and the second pattern portion (B).
  • the third pattern portion (C) has a greater width than the first concave portion 11 of the first pattern portion (A), and has a width greater than that of the second concave portion 21 of the second pattern portion (B). This can have the size of a small intermediate region.
  • the third pattern portion C may be alternately or repeatedly positioned with the outer first pattern portion A-2.
  • An embodiment of the present invention includes a pattern portion having an uneven portion in nanometer units to inhibit cell adhesion and proliferation and cell mobility due to an increase in surface roughness to prevent recurrence of eye diseases such as late-onset cataract.
  • a surface roughness having a complex dimension of micro and nano units is formed on the surface of the pattern part to more effectively prevent cell movement, proliferation, and aggregation.

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  • Health & Medical Sciences (AREA)
  • Ophthalmology & Optometry (AREA)
  • Cardiology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Prostheses (AREA)

Abstract

La présente invention comprend : une pièce optique qui sert de lentille de la lentille intraoculaire; et une pièce haptique qui s'étend à partir de la pièce optique et sert à supporter la position de la pièce optique, au moins l'un parmi une première partie de motif, qui comprend une première partie concave ou une première partie convexe présentant une fine partie concavo-convexe formée sur sa surface, et un deuxième motif, qui comprend une deuxième partie concave ou une deuxième partie convexe présentant une fine partie concavo-convexe formée sur sa surface, est positionné de façon alternée ou répétée sur au moins un côté de la pièce optique et de la pièce haptique, et au moins une partie parmi la première partie concave, la première partie convexe, la deuxième partie concave et la deuxième partie convexe présente une dimension différente, ce qui permet d'empêcher la récurrence de maladies oculaires telles que des cataractes tardives par inhibition de la mobilité cellulaire et régulation de la direction de migration cellulaire.
PCT/KR2021/006932 2020-06-04 2021-06-03 Lentille intraoculaire WO2021246799A1 (fr)

Applications Claiming Priority (2)

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KR10-2020-0067420 2020-06-04
KR1020200067420A KR102559052B1 (ko) 2020-06-04 2020-06-04 인공 수정체

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Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101257675B1 (ko) * 2008-07-15 2013-04-24 코와 가부시키가이샤 안내 렌즈 및 그 제조 방법
KR20160040807A (ko) * 2014-10-06 2016-04-15 한국과학기술연구원 미세패턴이 형성된 인공수정체
KR20170036056A (ko) * 2014-08-07 2017-03-31 샤크렛 테크놀러지스, 아이엔씨. 흐름 제어 및 생물흡착 제어를 위한 패턴
US20170189168A1 (en) * 2006-09-21 2017-07-06 Abbott Medical Optics Inc. Intraocular lenses for managing glare, adhesion, and cell migration
KR20200008417A (ko) * 2018-07-16 2020-01-28 한국과학기술연구원 인공수정체 및 이를 제조하는 방법

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100314665B1 (ko) 1999-08-19 2001-11-17 최시환 백내장 수술용 인공수정체

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20170189168A1 (en) * 2006-09-21 2017-07-06 Abbott Medical Optics Inc. Intraocular lenses for managing glare, adhesion, and cell migration
KR101257675B1 (ko) * 2008-07-15 2013-04-24 코와 가부시키가이샤 안내 렌즈 및 그 제조 방법
KR20170036056A (ko) * 2014-08-07 2017-03-31 샤크렛 테크놀러지스, 아이엔씨. 흐름 제어 및 생물흡착 제어를 위한 패턴
KR20160040807A (ko) * 2014-10-06 2016-04-15 한국과학기술연구원 미세패턴이 형성된 인공수정체
KR20200008417A (ko) * 2018-07-16 2020-01-28 한국과학기술연구원 인공수정체 및 이를 제조하는 방법

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