KR102559052B1 - Intraocular lens - Google Patents

Abstract

The present invention includes an optic unit serving as a lens of an intraocular lens and a haptic unit extending from the optic unit and serving to support the position of the optic unit, wherein at least one of a first pattern unit including a first concave portion or a first convex portion formed with fine concavo-convex portions formed on a surface and a second pattern portion including a second concave portion or second convex portion formed with fine concavo-convex portions are alternately or repeatedly positioned on at least one side of the optic portion and the haptic portion, the first concave portion, At least one of the first convex portion, the second convex portion, and the second convex portion has a different size, thereby inhibiting cell mobility and controlling the direction of cell migration to prevent the recurrence of eye diseases such as late cataract.

Description

Artificial lens {INTRAOCULAR LENS}

The present invention relates to an artificial lens.

In general, the structure and function of the human eye is similar to that of a camera. At the rear of the pupil, there is a lens made of transparent tissue in the shape of a convex lens, which functions as a camera lens. When the lens is damaged from the outside or becomes cloudy due to factors such as unnecessary abuse of eye drops, radiation irradiation, and exposure to various harmful electromagnetic waves, cataracts are induced.

One of the surgical methods for treating cataracts is implantation of an artificial lens capable of replacing the function of the lens. In this case, in most cases, the artificial lens is operated so as to be inserted inside a portion called a capsular bag in the eyeball or between the capsular bag and the iris. However, there is a possibility of opacity re-occurring even after the procedure due to proliferation and clustering of cells that cause late-onset cataract and migration toward the intraocular lens.

Therefore, there is a need for a technique capable of delaying or suppressing proliferation, clustering, and migration of cells that cause late-onset cataract.

Republic of Korea Patent Publication No. 2001-0018345 (2001. 03. 05)

An object of one embodiment of the present invention is to provide an intraocular lens that inhibits proliferation, crowding, and mobility of cells and controls the directionality of cell movement by alternately or repeatedly arranging a plurality of pattern portions having concavo-convex portions of different sizes.

An object of one embodiment of the present invention is to provide an intraocular lens in which surface roughness having complex dimensions of micro and nano units is formed on the surface of a pattern portion to more efficiently prevent cell migration, proliferation, and clustering.

It includes an optic unit serving as a lens of an artificial intraocular lens and a haptic unit extending from the optic unit and serving to support the position of the optic unit, wherein at least one of a first pattern unit including a first concave portion or a first convex portion having fine concavo-convex portions formed on a surface and a second pattern portion including a second concave portion or a second convex portion having fine concavo-convex portions formed on a surface are alternately or repeatedly positioned on at least one side of the optic unit and the haptic unit, At least one of the convex portion, the second convex portion, and the second convex portion has a different size.

In addition, the width of the second concave portion may be wider than that of the first concave portion.

In addition, as the distance from the center of the optic part increases, the first pattern part (hereinafter referred to as 'inner first pattern part') proximate to the optic part is repeatedly positioned, and then the second pattern part is positioned. The first pattern part (hereinafter referred to as 'outer first pattern part') may be repeatedly positioned outside the second pattern part.

In addition, the inner first pattern part and the second pattern part may be formed in the optical part.

In addition, the inner first pattern part, the second pattern part, and the outer first pattern part may be formed in the haptic part.

Also, the second pattern unit may be formed at a connection portion between the optic unit and the haptic unit.

Also, the outer first pattern part may be formed at a connection portion between the optic part and the haptic part.

In addition, it is located on the outside of the outer first pattern part based on the center of the optic part, and the size of the first pattern part and the second pattern part is different from the third concave portion having the fine concavo-convex portion. At least one third pattern portion including a third convex portion may be positioned alternately with the outer first pattern portion.

In addition, the first pattern part and the second pattern part may be alternately positioned with respect to the center of the optic part, and the size of the first pattern part relatively close to the center of the optic part may be smaller than the size of the second pattern part spaced apart from the center of the optic part more than the first pattern part.

In addition, the width of the second concave portion may be wider than that of the first concave portion.

In addition, the width of the first convex portion and the width of the second convex portion may be formed to be the same.

In addition, the first convex portion, the height of the second convex portion, the depth of the first concave portion and the second concave portion may be formed to have the same size.

In addition, the first convex portion, the height of the second convex portion, the depth of the first concave portion and the second concave portion may be formed in different sizes.

In addition, the width (R1) of the first convex portion is 5 μm, the width (G1) of the first concave portion is 10 μm, the width (R2) of the second convex portion is 5 μm, and the width (G2) of the second concave portion may be 20 μm or more or 30 μm or more.

In addition, the width R1 of the first convex portion is 10 μm, the width G1 of the first concave portion is 10 μm, the width R2 of the second convex portion is 10 μm, and the width of the second concave portion G2 is 20 μm or more or 30 μm or more.

In addition, the fine concavo-convex portion may be formed on surfaces of the first pattern part, the second pattern part, and the third pattern part in a micrometer unit or nanometer unit to have a surface roughness in a micrometer unit or nanometer unit.

In addition, the fine concavo-convex part may be provided as a microphone-unit concavo-convex part formed on a part of the surface of the first pattern part, provided as a nanometer-unit concavo-convex part formed on the remaining part of the surface of the first pattern part, and may be provided as a nanometer-unit concavo-convex part formed on the surface of the second pattern part.

In addition, the width ratio of the first convex portion and the first concave portion may be formed within a range of 1:2 to 1:8, and the width ratio of the second convex portion and the second concave portion may be formed within a range of 1:2 to 1:8.

One embodiment of the present invention is to alternately arrange a plurality of pattern parts having concavo-convex parts of different sizes to inhibit cell proliferation, crowding, and migration, and to control the direction of cell movement to prevent the recurrence of eye diseases such as late cataract. It is possible to provide an artificial intraocular lens.

An embodiment of the present invention may provide an intraocular lens in which surface roughness having complex dimensions of micro and nano units is formed on the surface of the pattern portion to more effectively prevent cell migration, proliferation, and clustering.

1 is a view showing an artificial intraocular lens according to an embodiment of the present invention;
Figure 2 is a cross-sectional view showing an embodiment of part A of Figure 1,
3 is a diagram illustrating surface roughness of a degree unit formed in a concave portion located in a first pattern part or a second pattern part in an intraocular lens according to an embodiment of the present invention;
4 is a schematic cross-sectional view for explaining the positions of a first pattern part and a second pattern part according to an embodiment of the present invention;
5a and 5b are depth and height variations of FIG. 4;
6a to 6c are examples of location variations of FIG. 4,
7 is a schematic cross-sectional view for explaining positions of a first pattern part, a second pattern part, and a third pattern part according to another embodiment of the present invention.

Hereinafter, specific embodiments of the present invention will be described with reference to the drawings. However, this is only an example and the present invention is not limited thereto.

In describing the present invention, if it is determined that a detailed description of the known technology related to the present invention may unnecessarily obscure the subject matter of the present invention, the detailed description will be omitted. In addition, terms to be described later are terms defined in consideration of functions in the present invention, which may vary according to the intention or custom of a user or operator. Therefore, the definition should be made based on the contents throughout this specification.

The technical spirit of the present invention is determined by the claims, and the following examples are only one means for efficiently explaining the technical spirit of the present invention to those skilled in the art to which the present invention belongs.

1A and 1B are diagrams illustrating an intraocular lens according to an embodiment of the present invention, and FIG. 2 is a cross-sectional view illustrating an embodiment of part A of FIG. 1A.

Referring to FIGS. 1A, 1B and 2 , the intraocular lens according to the present invention includes an optic unit 110 and a haptic unit 120. The optical unit 110 and the haptic unit 120 are integrally formed and may be connected to each other through a connecting portion, which is a circumferential surface indicated by reference numeral 130 in FIG. 1 . Here, the circumferential surface indicated by reference numeral 130 may be included in the optic unit 110 or the haptic unit 130 .

In addition, a first pattern unit (A) and a second pattern unit (B) may be positioned in the optic unit 110 and the haptic unit 120 to suppress proliferation, clustering, and movement of cells. Also, in some cases, as shown in FIG. 1B , the first pattern unit A and the second pattern unit B may not be formed in the haptic unit 120 .

The optic unit 110 serves as a lens of an intraocular lens and is formed in a circular shape, and the haptic unit 120 extends from the circumferential surface of the optic unit 110 formed in a circular shape and serves as a support to support the position of the optic unit 110.

The optic unit 110 and the haptic unit 120 may be made of various materials having transparency, but are preferably made of at least one of plastic, silicone, hydrogel, or acrylic, and more preferably made of acrylic resin or polymethyl methacrylate resin. It is effective to efficiently form and function the pattern of the present invention while realizing excellent crystalline function (polyHEMA, PMMA, etc.). However, the materials of the optic unit 110 and the haptic unit 120 are not limited thereto, and both hydrophillic biomaterial and hydrophobic biomaterial can be used.

A plurality of haptic units 120 may be positioned to be spaced apart from each other in the circumferential direction of the optic unit 110 to stably support the position of the optic unit 110 .

At least one first pattern unit (A) and at least one second pattern unit (B) may be alternately or repeatedly positioned on at least a portion of at least one of the optic unit 110 and the haptic unit 120. In addition, at least one first pattern part (A) and at least one second pattern part (B) may be alternately or repeatedly positioned on the optic unit 110 and the haptic unit 120, respectively.

The first pattern unit (A) and the second pattern unit (B) are positioned at the edges of the optic unit 110, that is, within a range partially extending from the outer periphery of the optic unit 110 toward the center, and may be located on either side of both sides of the optic unit 110 or on both sides of the optic unit 110, respectively. Furthermore, it may be located on the side of the optic unit 120.

In addition, the first pattern unit (A) and the second pattern unit (B) are formed on the surface of the haptic unit 120, and may be located on either side of both sides or on both sides of the haptic unit 120, respectively. Furthermore, it may be located on the side of the haptic unit 120.

In addition, the first pattern unit (A) and the second pattern unit (B) may also be located on the outer circumferential surface of the optic unit 110 and the haptic unit 120 .

The first pattern portion (A) is a pattern including at least one of the first concave portion 21 and the first convex portion 11, and the second pattern portion (B) is the second concave portion 22 and the second convex portion 12 It may be a pattern including at least one of.

For example, the first pattern portion A is a concave-convex pattern including at least one first concave portion 21 and at least one first convex portion 11 .

The width of the first concave portion 21 may be formed larger than the width of the first convex portion 11, and the width ratio of the first convex portion 11 and the first concave portion 21 may be formed within a range of 1:2 to 1:8.

For example, the second pattern portion B is a concave-convex pattern including at least one second concave portion 22 and at least one second convex portion 12 .

The width of the second concave portion 22 is formed larger than the width of the second convex portion 12, and the width ratio between the second convex portion 12 and the second concave portion 22 may be formed within a range of 1:2 to 1:8.

The first pattern portion (A) may be a pattern in which the first convex portion 11 and the first concave portion 21 are continuously repeated, and the second pattern portion (B) is the second convex portion 12 and the second concave portion 22 may be a pattern composed of a continuously repeated form.

The first pattern part (A) and the second pattern part (B) have different sizes from each other in at least one of height, depth, width, and roughness.

As shown in FIG. 2, the first concave portion 21 and the second concave portion 22 may have different sizes in at least one of the widths G1 and G2 and the depths D1 and D2, and the first convex portion 11 and the second convex portion 12 may have a different size in at least one of the widths R1 and R2 and the heights D1 and D2.

The first pattern portion (A) and the second pattern portion (B) include a first concave portion 21 and a second concave portion 22 in which at least one of the widths G1 and G2 and the depths D1 and D2 has a different size, or a first convex portion 11 and a second convex portion 12 in which at least one of the widths R1 and R2 and the heights D1 and D2 has a different size from each other.

In addition, the first pattern part (A) and the second pattern part (B) are positioned alternately with each other so that foreign substances, that is, ocular epithelial cells, do not move or grow toward the center of the optic part 110, but move or grow to the outside (outer periphery side) of the optic part 110.

The first pattern part (A) and the second pattern part (B) are alternately positioned in the radial direction with respect to the center of the optic part 110, and the size of the second pattern part (B) relatively farther from the center of the optic part 110 may be larger than the size of the first pattern part (A) closer to the center of the optic part 110 than the size of the first pattern part (A).

The first pattern unit (A) and the second pattern unit (B) may be positioned relative to the center of the optic unit 110, the first pattern unit (A), the second pattern unit (B), and the first pattern unit (A) may be continuously located, or the first pattern unit (A), the second pattern unit (B), the first pattern unit (A), and the second pattern unit (B) may be continuously located.

The width R1 of the first convex portion 11 and the width R2 of the second convex portion 12 are the same, and the width G1 of the first concave portion 21 and the width G2 of the second concave portion 22 have different sizes, but the width G2 of the second concave portion 22 may be formed wider than the width G1 of the first concave portion 21. That is, the width G1 of the first concave portion 21 may be narrower than the width G2 of the second concave portion 22 .

In addition, the height (D1) of the first convex portion 11, the height (D2) of the second convex portion 12, the depth (D1) of the first concave portion 21 and the depth (D2) of the second concave portion 22 is formed in the same size as an example.

For example, the width R1 of the first convex portion 11 is 3 to 7 μm, the width G1 of the first concave portion 21 is 5 to 15 μm, and the width R2 of the second convex portion 12 is 3 to 7 μm, and the width G2 of the second concave portion 22 may be 16 to 35 μm.

In more detail, the width R1 of the first convex portion 11 is 5 μm, the width G1 of the first concave portion 21 is 10 μm, and the width R2 of the second convex portion 12 is 5 μm. The width G2 of the second concave portion 22 may be 20 μm or more or 30 μm or more. However, it is not necessarily limited thereto, and the width R1 of the first convex portion 11 and the width R2 of the second convex portion 12 may be 10 μm.

As the width G1 of the first recessed portion 21 and the width G2 of the second recessed portion 22 widen in the width direction within the above ranges, the expression of proteins for adhesion of cells increases, and as a result, the mobility of the cells increases. As the width G1 of the first recessed portion 21 and the width G2 of the second recessed portion 22 increase, the expression of proteins for attachment is suppressed and the mobility of cells may decrease. However, when the waist portion is formed with a width less than the size of the cell in consideration of the size of the cell or when the surface of the waist portion has a roughness of 200 nm or less, the expression of cell adhesion proteins and the interaction between cells are activated to induce the formation of a colony and increase the movement speed of the cell population. ) When the width (G2) is 20 μm or more or 30 μm or more, the expression of the cell adhesion protein and the interaction between the cells attached to the first pattern portion (A) and the second pattern portion (B) are inhibited, so that the movement speed of the cells can be most greatly reduced.

In the present invention, the first pattern part (A) and the second pattern part (B) are alternately positioned, but the width of the first recessed part 21 is narrower than the width of the second recessed part 22, so that the cells that have moved from the haptic part 120 to the optic part 110 are moved in a direction away from the center of the optic part 110 again. It is possible to suppress the movement to the optic unit 110 by attaching it to the pattern part (B).

In addition, the first lumbar portion 21, the first convex portion 11, the second lumbar portion 22, and the second convex portion 12 are formed in a closed curve shape or a closed loop shape so that the first lumbar portion 21 or the second lumbar portion 22 can be filled with as many cataract-inducing cells as possible, and the cataract-inducing cells grow and proliferate along the first lumbar portion 21 or the second lumbar portion 22 to form a first After being filled in the lumbar portion 21 or the second lumbar portion 22, the first convex portion 11 or the second convex portion 12 is inserted into the next first lumbar portion 21 or the second lumbar portion 22 to be filled. The growth, proliferation, and spread of cells that cause cataracts are minimized, thereby reflexively slowing down the speed to the maximum.

However, the first concave portion 21 and the first convex portion 11 and the second concave portion 22 and the second convex portion 12 are formed in a closed curve shape or are not limited to a closed loop shape.

The artificial lens according to the present invention removes a cloudy lens from a cataract patient, is implanted into a human body to replace the removed lens, and becomes opaque again due to a small amount of late-onset cataract-causing cells remaining in the human body after implantation. Therefore, it may be necessary to minimize and prevent cataract-inducing cells from migrating or proliferating to the inside of the optic unit 110.

That is, the first pattern unit (A) and the second pattern unit (B) are located near the outer periphery of the optic unit 110, that is, near the boundary between the optic unit 110 and the haptic unit 120, to prevent ocular epithelial cells from migrating or proliferating to the inside of the optic unit 110, and directing cells that cause cataract to the outside of the optic unit 110, that is, The movement of cataract-inducing cells in a direction away from the center of the optic unit 110 and the interaction of cells with each other are induced, so that cataract-inducing cells proliferate and form clusters to prevent the occurrence of late-onset cataracts that cover the optic unit 110.

On the other hand, the first pattern portion (A) and the second pattern portion (B) include micrometer-unit or nanometer-unit concavo-convex portions (hereinafter, abbreviated as 'fine concavo-convex portions') formed on their surfaces, whereby the first pattern portion (A) and the second pattern portion (B) may have surface roughness in micrometer or nanometer units.

On the surface of the first pattern portion A, that is, on the surface of the first convex portion 11 and the first concave portion 21, surface roughness is formed by micro- and nano-level concavo-convex portions, and on the surface of the second pattern portion B, surface roughness is formed by nanometer-level concavo-convex portions to limit the attachment and proliferation of cells that cause cataracts, thereby delaying their migration toward the center of the optic unit 110 as much as possible.

That is, a portion of the surface of the first pattern portion A has concavo-convex portions in micrometer units, the remaining portion of the surface of the first pattern portion A has concavo-convex portions in nanometer units, and the surface of the second pattern portion B may have concavo-convex portions in nanometer units.

More specifically, FIG. 3 is a diagram illustrating surface roughness in nano units formed on concave portions located in the first pattern portion (A) or the second pattern portion (B) in the intraocular lens according to an embodiment of the present invention.

It shows that a nanometer unit structure is formed on the surface of the first concave portion 21 or the second concave portion 22, and processing protrusions 510 and 520 may be provided.

The processing protrusions 510 and 520 may be formed in micrometer units or nanometer units, and may be formed as a structure for delaying or inhibiting cell attachment, proliferation, and movement. For example, the processing protrusions 510 and 520 in nanometer units extend vertically upward, downward, horizontally, in an upper oblique direction, or in a lower oblique direction from the surface of the first concave portion 21 or the second concave portion 22. Can be formed. In addition, although not shown in the drawings of the present invention, the cross-sectional shape of the first recessed portion 21 or the second recessed portion 22 may be formed in a 'U' shape, and similarly, the processing protrusions 510 and 520 in nanometer units may be formed extending vertically upward, downward, horizontally, in an upper oblique direction, or in a lower oblique direction from the surface of the first recessed portion 21 or the second recessed portion 22.

And, the size (height, width, spacing) of the processing protrusions 510 and 520 may be formed in the range of 0.01 μm to 10 μm. When the surface roughness of the protrusions 510 and 520 is formed with a size of 0.2 μm or more, cell adhesion is suppressed and the number of cells tends to decrease. However, after 6 hours, the cells do not spread widely and maintain a round shape, and after 24 hours, the cells become elongated to adhere to a stable surface. When the processing protrusions 510 and 520 have a size of less than 0.1 μm or greater than 10 μm, they do not have a significant effect on cell adhesion, thereby reducing the inhibitory force on cell mobility, and when the size ranges from 0.1 to 1 μm, the inhibitory force on cell mobility may increase. In particular, when the processing protrusions 510 and 520 have a size in the range of 0.1 to 0.2 μm, they are stably attached to the surface of the intraocular lens to prevent cataract-causing cells traveling along the posterior capsule from migrating to the optic unit 110, thereby effectively inhibiting their mobility.

In addition, the width w of the processing protrusions 510 and 520 may be formed in the range of 0.1 μm to 10 μm. When the protrusion width (w) is formed to be less than 0.1 μm, the height that can be extended from the surface of the first recessed portion 21 or the second recessed portion 22 is shortened, making it difficult to perform the function of inhibiting cell movement. When the protrusion width (w) exceeds 10 μm, the number of processing protrusions 520 that can be provided in the processing groove decreases, making it difficult to secure bonding force. Accordingly, the protrusion width (w) may be formed in a range between 0.1 μm and 10 μm.

A laser is irradiated in a laser irradiation direction L, and a processing groove may be formed in the intraocular lens 100 . While the concave portions 21 and 22 are formed, convex portions 11 and 12 may be formed on both sides. That is, the concave portions 21 and 22 formed by opening between the adjacent convex portions 11 and 12 may be formed to a predetermined depth D1 and D2. Protrusions 510 and 520 and recessed parts 21 and 22 may be formed more finely in the recesses 21 and 22, which will be described later through drawings shown to be more intuitively revealed in the following drawings.

Meanwhile, as the laser is irradiated in the laser irradiation direction L, concave portions 21 and 22 may be formed in the intraocular lens 100 .

Therefore, the first concave portion 21 or the second concave portion 22 may be formed in a concave shape by a predetermined depth, which may be formed in the shape of a groove, a non-through hole, or a drain.

Here, the predetermined depth may be determined according to laser irradiation conditions and the material of the intraocular lens 100 . For example, laser irradiation conditions may include laser power, laser frequency, laser irradiation time, laser spot size, processing speed, and the like.

Specifically, when laser is irradiated to the intraocular lens 100 to form the first concave portion 21 or the second concave portion 22 to the predetermined depth, a processing groove corresponding to the target depth may not be formed by one irradiation. That is, as the output of the laser increases, the predetermined depth can be formed in a shorter time. Of course, when processing is performed with a high-output laser through a small number of irradiations, thermal deformation may occur depending on the material of the intraocular lens 100, and the possibility that the intraocular lens 100 may be damaged by the laser may increase. In addition, the surface of the first concave portion 21 or the second concave portion 22 processed by a high-power laser may have a larger roughness than the surface of the first concave portion 21 or the second concave portion 22 processed multiple times by a low-power laser.

Here, processing by laser irradiation twice or more means a depth that can be formed by laser irradiation once, and for this purpose, the area to which the laser is irradiated to the first object 100 may overlap. A method of irradiating the first object 100 with overlapping laser beams may be a method of irradiating two or more laser beams to a portion of the first object 100 at a time or distance interval. Meanwhile, the rate at which lasers overlap may be referred to as an overlap rate.

The spot size, frequency, scan interval, and scan speed of the irradiated laser may be factors that determine the overlap rate of the laser, and the predetermined depth may be determined by the overlap rate. For example, the shorter the period of the frequency and the faster the scan speed, the lower the overlap rate. Conversely, the longer the period of the frequency and the slower the scan speed, the higher the overlap rate. Here, the high overlap ratio means that the specific gravity applied per unit area of the amount of energy emitted from the laser increases, so that the predetermined depth can be reached by selectively determining the laser frequency and scan speed.

In addition, even when repeated processing is performed under the above laser conditions, the predetermined depth can be reached.

Accordingly, the depth of the first concave portion 21 or the second concave portion 22 formed by laser irradiation is a factor that can be selectively determined in consideration of conditions such as the material of the intraocular lens 100, laser output, laser frequency, laser spot size, scanning interval, scanning speed, and the number of repetitions of processing, and this can also be determined for the first concave portion 21 or the second concave portion 22 and the processing protrusion 520 described in the present invention according to the above-described conditions.

4 is a cross-sectional schematic diagram for explaining the positions of a first pattern part and a second pattern part according to an embodiment of the present invention, FIGS. 5A and 5B are depth and height variations of FIG. 4, and FIGS. 6A to 6C are positions variations of FIG. 4, and FIG.

4, in one embodiment of the present invention, after at least one first pattern portion (A, A-1) having fine concavo-convex portions formed on the surface is repeatedly disposed in a direction away from the center of the optic unit 110, then at least one second pattern portion (B) having fine concavo-convex portions formed on the surface is repeatedly positioned outside the first pattern portion (A, A-1), and then the first pattern portions (A, A-2) are placed outside the second pattern portion (B). At least one or more may be repeatedly positioned on the side.

Hereinafter, the first pattern part (A) located relatively close to the optic part 110 compared to the second pattern part (B) among the first pattern parts (A) is defined as an 'inner first pattern part', and a reference numeral 'A-2' is indicated to describe it separately from the 'outer first pattern part (A-2)' provided on the outside of the second pattern part (B).

As described above, in one embodiment of the present invention, the inner first pattern part A-1, the second pattern part B, and the outer first pattern part A-2 are repeated or alternately positioned in a direction away from the optic part 110 as the center, thereby presenting an optimal structure for suppressing cell movement.

In addition, in one embodiment of the present invention, as shown in FIG. 5A, the height D1 of the first convex portion 11 of the inner first pattern portion A-1, the second pattern portion B, and the outer first pattern portion A-2, the height D1 of the second convex portion 12, the depth D1 of the first concave portion 21, and the depth D2 of the second concave portion 22 may all be formed in the same size. Or, as referenced in FIG. 5B, the height D2 of the second pattern portion B, the depth D1 of the first concave portion 21, and the depth D2 of the second concave portion 22 are the outer first pattern portion A-2 and / or the inner first pattern portion A-1. D1) and the second concave portion 22 may be formed lower than the depth (D2).

Here, as shown in FIG. 6A , the inner first pattern part A-1 and the second pattern part B may be formed to be positioned on the optic part 110. However, the outer first pattern unit A-2 may be positioned on the optic unit 110 or only on the haptic unit 120.

Also, as shown in FIG. 6B , the inner first pattern part A-1, the second pattern part B, and the outer first pattern part A-2 may be formed to be positioned on the haptic part 120.

However, the first pattern part (A) and the second pattern part (B) are not necessarily positioned uniformly as described above, and as shown in FIG. 6C, the positional order of the inner first pattern part (A-1), the second pattern part (B), and the outer first pattern part (A-2) is fixed, but the second pattern part (B) may be formed to be located at the connection part 130 of the optic part 110 and the haptic part 120. do

On the other hand, one embodiment of the present invention described above includes only the first pattern portion (A) and the second pattern portion (B), but as referenced in FIG. 7, the third concave portion having fine concavo-convex portions and at least one third pattern portion (C) including a third convex portion may be further included.

The third pattern part (C) may be provided to have a size different from the sizes of the first pattern part (A) and the second pattern part (B). Preferably, the third pattern portion (C) has a larger width than the first concave portion 11 of the first pattern portion (A) and a smaller middle region than the second concave portion 21 of the second pattern portion (B).

As shown in FIG. 7 , the third pattern portion C may be alternately or repeatedly positioned with the outer first pattern portion A-2.

An embodiment of the present invention includes a pattern portion having nanometer-scale concavo-convex portions to prevent recurrence of eye diseases such as late cataract by inhibiting cell adhesion, proliferation, and cell mobility due to an increase in surface roughness.

In one embodiment of the present invention, surface roughness having complex dimensions of micro units and nano units is formed on the surface of the pattern portion to more effectively prevent cell migration, proliferation, and clustering.

Representative embodiments of the present invention have been described in detail above, but those skilled in the art will understand that various modifications are possible to the above-described embodiments without departing from the scope of the present invention. Therefore, the scope of the present invention should not be limited to the described embodiments and should not be defined, and should be defined by not only the claims to be described later, but also those equivalent to these claims.

11: first iron part 12: second iron part
21: first lumbar region 22: second lumbar region
110: optic unit 120: haptic unit
510, 520: processing protrusion
A: first pattern part B: second pattern part
D1: Depth of the first recess (height of the first convex part)
D2: Depth of the second recess (height of the second convex part)
G1: width of the first lower part
G2: width of the second recess
R1: Width of the first convex part
R2: Width of the first convex part
rw: projection spacing
r: projection width
L: laser irradiation direction
M1, M2: movement direction
G: boundary

Claims (21)

An optic unit serving as a lens of an artificial intraocular lens; and
A haptic unit extending from the optic unit and serving to support the position of the optic unit;
On at least one side of the optic part and the haptic part, at least one of a first pattern part including a first recessed part or a first convex part having fine concavo-convex parts formed on a surface thereof and a second pattern part including a second concave part or a second convex part formed with fine concavo-convex parts are alternately or repeatedly positioned, and at least one of the first concave part, the first convex part, the second concave part, and the second convex part has a different size,
The width of the second concave portion is wider than the first concave portion,
As the distance from the center of the optic part increases, the first pattern part (hereinafter referred to as 'inner first pattern part'), which is closer to the optic part, is repeatedly positioned, and then the second pattern part is positioned, and the first pattern part (hereinafter referred to as 'outer first pattern part') is repeatedly positioned in a direction away from the center of the optic part;
The fine concavo-convex part,
The intraocular lens having a roughness of a complex dimension including a micrometer unit or a nanometer unit on surfaces of the first pattern part and the second pattern part.
delete delete The method of claim 1,
The inner first pattern part and the second pattern part are formed in the optic part. The method of claim 1,
The inner first pattern part, the second pattern part, and the outer first pattern part are formed on the haptic part. The method of claim 1,
The second pattern part is formed at a connection portion between the optic part and the haptic part. The method of claim 1,
The outer first pattern part is formed at a connection portion between the optic part and the haptic part. The method of claim 1,
At least one third pattern part, which is located outside the outer first pattern part with respect to the center of the optic part, and is different in size from the first pattern part and the second pattern part and includes a third concave part having the fine concavo-convex part and a third convex part, is positioned alternately with the outer first pattern part. The method of claim 1,
The first pattern part and the second pattern part are alternately positioned based on the center of the optical part,
The intraocular lens of claim 1 , wherein a size of the first pattern part relatively close to the center of the optic part is smaller than a size of the second pattern part relatively farther from the center of the optic part than the first pattern part. The method of claim 1,
The artificial intraocular lens, wherein a width of the first convex portion and a width of the second convex portion are formed to be the same. The method of claim 10,
The artificial intraocular lens, wherein the height of the first convex portion and the second convex portion, and the depth of the first concave portion and the second concave portion are formed to have the same size. The method of claim 10,
The artificial lens of claim 1 , wherein heights of the first and second convex portions and depths of the first and second concave portions are different from each other. The method of claim 1,
The width (R1) of the first convex portion is 5 μm, the width (G1) of the first concave portion is 10 μm,
A width (R2) of the second convex portion is 5 μm, and a width (G2) of the second concave portion is 20 μm or more or 30 μm or more. The method of claim 1,
The width (R1) of the first convex portion is 10 μm, the width (G1) of the first concave portion is 10 μm,
A width (R2) of the second convex portion is 10 μm, and a width (G2) of the second concave portion is 20 μm or more or 30 μm or more. The method of claim 8,
The artificial lens of claim 1 , wherein the fine concavo-convex portion is formed on a surface of the third pattern portion in a micrometer unit or nanometer unit and has a surface roughness in a micrometer unit or nanometer unit. The method of claim 15
The fine concavo-convex part,
It is provided with irregularities in units of microphones formed on a part of the surface of the first pattern part, and irregularities in units of nanometers formed in the remaining part of the surface of the first pattern part,
An artificial intraocular lens comprising nanometer unit concavo-convex portions formed on the surface of the second pattern portion. The method of claim 1,
The width ratio of the first convex portion and the first concave portion is formed within the range of 1:2 to 1:8,
wherein a width ratio of the second convex portion and the second concave portion is within a range of 1:2 to 1:8. delete delete delete delete