WO2021227700A1 - 一种抗干敏组合物及其制备方法 - Google Patents
一种抗干敏组合物及其制备方法 Download PDFInfo
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- WO2021227700A1 WO2021227700A1 PCT/CN2021/085223 CN2021085223W WO2021227700A1 WO 2021227700 A1 WO2021227700 A1 WO 2021227700A1 CN 2021085223 W CN2021085223 W CN 2021085223W WO 2021227700 A1 WO2021227700 A1 WO 2021227700A1
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Definitions
- the invention belongs to the technical field of cosmetics, and particularly relates to an anti-dry allergy composition and a preparation method thereof.
- shower gels There are many kinds of shower gels on the market, but there are very few shower gels developed specifically for people who are sensitive, dry skin, itchy, and problematic skin with their own defects. These skins need to be gentle and clean at the same time. To moisturize and moisturize, anti-allergic, anti-inflammatory and other multiple functions, so it is very important to develop a shower gel suitable for this kind of people.
- the present application provides a plant extract composition, including spring elm extract, licorice extract, grapefruit extract, water chestnut extract, and wallflower juice extract, all of which are approved by a cosmetic raw material supplier (Korea Balonde) ) To obtain the following components by weight percentage of each extract: spring elm extract is 0.1-30%, licorice extract is 0.05-45%, grapefruit extract is 0.01-26%, and Brasenia fragrans extract is 0.05 -20%, 0.02-35% of wallflower juice extract
- Spring elm extract extracted from the root bark of the elm tree, rich in polysaccharides such as galactose, rhamnose, glucose, glucosamine, trehalose, etc. from natural sources. It can inhibit the activity of hyaluronidase, reduce the loss of transdermal moisture, and has strong moisturizing and anti-aging effects. And spring elm extract can also repair damage caused by UVA irradiation, improve cell survival, and also has good anti-inflammatory effects.
- Licorice extract The main ingredient is glycyrrhizic acid, which can effectively scavenge free radicals and inhibit the activity of lipoxygenase, thus having anti-aging and anti-inflammatory effects.
- Gluco grapefruit extract It has a broad-spectrum antibacterial effect and can inhibit the growth of bacteria such as Escherichia coli, Staphylococcus aureus, Bacillus subtilis and Candida albicans.
- Brasenia extract The back of Brasenia leaf secretes a mucus similar to agar. This mucus is rich in carbohydrates and can form a protective film on the skin to lock in more water and improve the moisture retention of the skin. Anti-pollution and anti-oxidation ability.
- Wallflower Juice Extract The skin-beautifying vitality of Wallflower Juice can moisturize the skin and strengthen the skin barrier.
- the present application provides a composition comprising the following components in weight percentage: 10-40% of anionic surfactants, 1-12% of nonionic surfactants, and 1-28% of zwitterionic surfactants ,
- the plant extract composition is 0.5-40%
- the oil is 0.5-35%
- the skin conditioner is 0.1-6%.
- the anionic surfactant is selected from sodium lauroyl sarcosinate, sodium lauroyl alaninate, sodium lauroyl glutamate, sodium lauroyl oat amino acid, sodium cocoyl malate amino acid or coconut oil At least one of sodium acylmethyl taurine taurate.
- the anionic surfactant is selected from the following components by weight percentage: sodium lauroyl sarcosinate 3-30%, preferably 6-20%; sodium lauroyl alanine 0.5-10% , Preferably 1-7%; sodium lauroyl glutamate 0.1-9%, preferably 0.5-6%; sodium lauroyl oat amino acid 0.2-11%, preferably 0.5-8%; sodium cocoyl malate amino acid 0.5-12% , Preferably 1-5%; sodium cocoyl methyl taurine taurate 1-12%, preferably 3-8%.
- the nonionic surfactant is selected from at least one of cocamide MEA or cocamide methyl MEA.
- the nonionic surfactant is selected from the following components by weight percentage: Cocamide MEA 0.1-5%, preferably 0.5-2%; Cocamide methyl MEA 0.2-6% , Preferably 0.6-3%.
- the zwitterionic surfactant is selected from at least one of cocamidopropyl betaine, sodium lauroamphoacetate, or lauroyl hydroxysultaine.
- the zwitterionic surfactant is selected from the following components by weight percentage: cocamidopropyl betaine 0.5-25%, preferably 1-20%; sodium lauroamphoacetate 0.3-13 %, preferably 0.4-12%; lauroyl hydroxysultaine 0.1-23%, preferably 0.3-9%.
- the plant extract composition is selected from the following components by weight percentage: spring elm extract 0.1-20%, preferably 0.5-15%; licorice extract 0.1-16%, preferably 0.3- 15%; grapefruit extract 0.2-8%, preferably 0.5-6%; Brasenia brasiana extract 0.03-17%, preferably 0.1-11%; wallflower juice extract 0.03-5%, preferably 0.2-4%.
- the oil is selected from at least one of PEG-7 glyceryl cocoate, isostearic acid, or glyceryl laurate.
- the oil is selected from the following components by weight percentage: PEG-7 glycerol cocoate 0.1-4%, preferably 0.2-1%; isostearic acid 0.1-2%, preferably 0.2 -1%; glycerol laurate 0.1-5%, preferably 0.2-3%.
- the skin conditioning agent is selected from at least one of Polyquaternium-7 or Polyquaternium 10.
- the skin conditioning agent is selected from the following components in weight percentage: Polyquaternium-70.05-1%, preferably 0.1-0.6%, Polyquaternium 10 0.01-2%, preferably 0.1- 0.6%.
- one or more of preservatives, chelating agents, pH adjusters, flavors, or water are also included.
- the preservative is selected from at least one of phenoxyethanol, ethylhexylglycerol, or p-hydroxyacetophenone.
- the preservative is selected from the following components by weight percentage: phenoxyethanol 0.2-1%, preferably 0.3-0.6%, ethylhexylglycerol 0.1-1%, preferably 0.2-0.6%, 0.1-1% of p-hydroxyacetophenone, preferably 0.2-0.5%.
- the chelating agent is selected from EDTA-2Na; preferably, the weight percentage of the chelating agent is 0.1-0.6%, preferably 0.2-0.4%.
- the pH adjusting agent is selected from at least one of citric acid, sodium citrate, aminomethylpropanol, or triethanolamine.
- the pH adjusting agent is selected from citric acid; further preferably, the weight percentage of citric acid is 0.01-8%.
- the weight percentage of the fragrance is 0.02%.
- this application also provides a preparation method of the combination, which is characterized in that it comprises the following steps:
- the combination of several plant extracts in this application has the functions of moisturizing, moisturizing, anti-allergic, anti-inflammatory, etc. These extracts are added in cosmetics to achieve the effects of anti-dry skin, repairing skin barrier, soothing and anti-allergy, anti-oxidation, etc. . With amino acid surfactants, and by adding oils and skin conditioners, a mild and foam-rich amino acid composition structure is formed.
- the shower gel of the present invention achieves a synergistic effect through the combination of various components.
- composition of the present application has been experimentally verified and is non-irritating to the human body.
- the preparation method of the shower gel composition of the present invention has high safety and low cost, and is suitable for industrial large-scale production.
- Example 1-3 Shower gel containing the composition of the present application
- Example 1-3 shower gel The preparation method of Example 1-3 shower gel is as follows:
- Comparative Example 13 The difference from Example 1 is that Comparative Example 13 does not contain an anionic surfactant.
- the shower gel composition of the present invention is easier to rinse off after use, skin moisture retention, anti-itching, and scaly improvement after use. Compared with the commercially available amino acid shower gel A, it has greater advantages. The advantages. Generally favored by testers.
- Comparative Example 7 and Comparative Example 8 and Example 1 The difference between Comparative Example 7 and Comparative Example 8 and Example 1 is that no oil and skin conditioner are included, and the scores of the shower gel in terms of moisturizing etc. are poor after use.
- Comparative Example 11 and Comparative Example 12 and Example 1 are not contain amphoteric surfactants and non-ionic surfactants.
- Comparative Example 13 The difference between Comparative Example 13 and Example 1 is that it does not contain an anionic surfactant. After the shower gel is used, the scores are poor in terms of foam density, skin cleanliness, and overall satisfaction.
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Abstract
一种抗干敏组合物以及制备方法，所述的组合物以总质量计，包括以下组分：阴离子表面活性剂10-40％，非离子表面活性剂1-12％，两性离子表面活性剂1-28％，植物提取物组合物0.5-40％，油脂0.5-35％，皮肤调理剂0.1-6％。通过氨基酸表面活性剂之间的合理搭配，形成了温和，泡沫丰富的氨基酸组合的架构，较与传统表面活性剂更加温和清洁功能，避免过度脱脂，使皮肤干燥，并且搭配植物提取物组合物，对皮肤起到抗敏感、抗炎、保湿等多重功能，沐浴露通过各个组分组合，达到协同增效的作用。可以温和清洁、滋润保湿、抗敏感等多重功效，对皮肤无刺激，安全温和。进一步地，沐浴露组合物的制备方法，具有很高的安全性和较低的成本，适合工业大规模的生产。
Description
本发明属于化妆品技术领域，尤其涉及一种抗干敏组合物和其制备方法。
随着生活水平的提高，沐浴露的使用频率升高，但是随着沐浴露选用不当、频繁使用、自身使用方式不当以及自身的肌肤问题等多种因素的影响，导致部分人群会出现肌肤易起干皮、瘙痒、易过敏等问题。
目前市面的沐浴露有很多种，但专门针对易敏感、皮肤易干燥、易瘙痒、有自身缺陷的问题肌肤等人群研发的沐浴露，很少，这些肌肤需要在温和洁肤的同时，并且起到滋润保湿、抗过敏、抗炎症等多重功效，所以专门开发一款适合这类人群的沐浴露显得至关重要。
发明内容
一方面，本申请提供了一种植物提取物组合物，包括春榆提取物、甘草提取物、葡萄柚提取物、莼菜提取物和桂竹汁提取物，均通过化妆品原料供应商(韩国百朗德)得到，所述各提取物以重量百分比计以下组分：春榆提取物为0.1-30％，甘草提取物为0.05-45％，葡萄柚提取物为0.01-26％，莼菜提取物为0.05-20％，桂竹汁提取物为0.02-35％
春榆提取物：提取自榆树的根皮部，富含天然来源的半乳糖、鼠李糖、葡糖糖、氨基葡萄糖、海藻糖等多糖。能抑制透明质酸酶的活性，减少透皮水分流失，具有强效保湿和抗衰老的功效。并且春榆提取物也能够修复UVA照射引起的损伤，提高细胞存活能力，同时还具有良好的抗炎功效
甘草提取物：主要成分甘草酸，能够有效清除自由基并能抑制脂肪氧化酶的活性，从而具有抗衰老和抗炎的功效。
葡糖柚提取物：具有广谱抑菌功效，可抑制大肠杆菌、金黄色葡萄球菌、枯草芽孢杆菌和白色念珠菌等菌种生物生长。
莼菜提取物：莼菜叶的背面会分泌一种类似琼脂的黏液，这种黏液富含糖类，可以在皮肤上形成一层保护膜，使其锁住更多水分，提高肌肤保湿度，并且具有抗污染和抗氧化能力。
桂竹汁提取物：桂竹汁液的美肤活力，可以对皮肤起到保湿肌肤，增强皮肤屏障的功效。
一方面，本申请提供了一种组合物，包括以重量百分比计的以下组分：阴离子表面活性剂10-40％，非离子表面活性剂1-12％，两性离子表面活性剂1-28％，所述的植物提取物组合物0.5-40％，油脂0.5-35％，皮肤调理剂0.1-6％。
在一些实施方案中，所述阴离子表面活性剂选自月桂酰肌氨酸钠、月桂酰丙氨酸钠、月桂酰谷氨酸钠、月桂酰燕麦氨基酸钠、椰油酰苹果氨基酸钠或椰油酰甲基牛磺酸牛磺酸钠中的至少一种。
在一些实施方案中，所述阴离子表面活性剂选自以重量百分比计的以下组分：月桂酰肌氨酸钠3-30％，优选6-20％；月桂酰丙氨酸钠0.5-10％，优选1-7％；月桂酰谷氨酸钠0.1-9％，优选0.5-6％；月桂酰燕麦氨基酸钠0.2-11％，优选0.5-8％；椰油酰苹果氨基酸钠0.5-12％，优选1-5％；椰油酰甲基牛磺酸牛磺酸钠1-12％，优选3-8％。
在一些实施方案中，所述非离子表面活性剂选自椰油酰胺MEA或椰油酰胺甲基MEA中的至少一种。
在一些实施方案中，所述非离子表面活性剂选自以重量百分比计的以下组分：椰油酰胺MEA 0.1-5％，优选0.5-2％；椰油酰胺甲基MEA0.2-6％，优选0.6-3％。
在一些实施方案中，所述两性离子表面活性剂选自椰油酰胺丙基甜菜碱、月桂酰两性乙酸钠或月桂酰羟基磺基甜菜碱中的至少一种。
在一些实施方案中，所述两性离子表面活性剂选自以重量百分比计的以下组分：椰油酰胺丙基甜菜碱0.5-25％，优选1-20％；月桂酰两性乙酸钠0.3-13％，优选0.4-12％；月桂酰羟基磺基甜菜碱0.1-23％，优选0.3-9％。
在一些实施方案中，所述植物提取物组合物选自以重量百分比计的以下组分：春榆提取物0.1-20％，优选0.5-15％；甘草提取物0.1-16％，优选0.3-15％；葡萄柚提取物0.2-8％，优选0.5-6％；莼菜提取物0.03-17％，优选0.1-11％；桂竹汁提取物0.03-5％，优选0.2-4％。
在一些实施方案中，所述油脂选自PEG-7甘油椰油酸酯、异硬脂酸或甘油月桂酸酯中的至少一种。
在一些实施方案中，所述油脂选自以重量百分比计的以下组分：PEG-7甘油椰油酸酯0.1-4％，优选0.2-1％；异硬脂酸0.1-2％，优选0.2-1％；甘油月桂酸酯0.1-5％，优选0.2-3％。
在一些实施方案中，所述皮肤调理剂选自聚季铵盐-7或聚季铵盐10中的至少一种。
在一些实施方案中，所述皮肤调理剂选自以重量百分比计的以下组分聚季铵盐-70.05-1％，优选0.1-0.6％，聚季铵盐10 0.01-2％，优选0.1-0.6％。
在一些实施方案中，还包括防腐剂、螯合剂、pH调节剂、香精或水中的一种或多种。
在一些实施方案中，所述防腐剂选自苯氧乙醇、乙基己基甘油或对羟基苯乙酮中的至少一种。
在一些实施方案中，所述防腐剂选自以重量百分比计的以下组分：苯氧乙醇0.2-1％，优选0.3-0.6％，乙基己基甘油0.1-1％，优选0.2-0.6％，对羟基苯乙酮0.1-1％，优选0.2-0.5％。
在一些实施方案中，所述螯合剂选自EDTA-2Na；优选地，所述螯合剂的重量百分比为0.1-0.6％，优选0.2-0.4％。
在一些实施方案中，所述pH调节剂选自柠檬酸、柠檬酸钠、氨甲基丙醇或三乙醇胺中的至少一种。
在一些实施方案中，所述pH调节剂选自柠檬酸；进一步优选柠檬酸的重量百分比为 0.01-8％。
在一些实施方案中，所述香精的重量百分比为0.02％。
一方面，本申请还提供了所述的组合的制备方法，其特征在于，包括以下步骤：
1)将阴离子表面活性剂和水加入反应釜中，搅拌，加热75-80℃；
2)加入两性离子表面活性，搅拌均匀；
3)再加入非离子表面活性剂，螯合剂，搅拌均匀，保温20-30min降温；
4)降温到45℃，加入植物组合物，防腐剂，油脂，搅拌均匀；
5)加入皮肤调理剂、香精，调节pH到5.5-7.3；
6)冷却至37℃，过滤。
本申请取得的有益效果：
本申请的几种植物提取物合用，具有滋润保湿、抗敏、抗炎等功效，这几种提取物添加在化妆品中，可以达到抗皮肤干燥、修复肌肤屏障、舒缓抗敏、抗氧化等效果。搭配氨基酸表面活性剂，再通过添加油脂、皮肤调理剂，形成了温和，泡沫丰富的氨基酸组合物的架构，本发明的沐浴露通过各个组分组合，达到协同增效的作用。
进一步地，本申请的组合物经过实验验证，对人体无刺激性，本发明的沐浴露组合物的制备方法，具有很高的安全性和较低的成本，适合工业大规模的生产。
以下通过具体的实施例进一步说明本发明的技术方案，具体实施例不代表对本发明保护范围的限制。其他人根据本发明理念所做出的一些非本质的修改和调整仍属于本发明的保护范围。
实施例1-3 包含本申请组合物的沐浴露
按照表1准备沐浴露各组分。
表1 实施例1-3沐浴露配方表
实施例1-3沐浴露的制备方法如下：
①将月桂酰肌氨酸钠，月桂酰丙氨酸钠，月桂酰谷氨酸钠，月桂酰燕麦氨基酸钠，椰油酰苹果氨基酸钠，椰油酰甲基牛磺酸牛磺酸钠和水加入反应釜中，搅拌均匀，加热75-80℃；
②加入椰油酰胺丙基甜菜碱，月桂酰两性乙酸钠，月桂酰羟基磺基甜菜碱，搅拌均匀；
③再加入椰油酰胺MEA，椰油酰胺甲基MEA，EDTA-2Na，搅拌均匀，保温20-30min降温；
④降温到65℃，加入对羟基苯乙酮；
⑤降温到45℃，加入春榆提取物，甘草提取物，葡萄柚提取物，莼菜提取物，桂竹汁提取物，PEG-7甘油椰油酸酯，异硬脂酸，甘油月桂酸酯，苯氧乙醇，乙基己基甘油，搅拌均匀；
⑥加入聚季铵盐-7，聚季铵盐10，香精，用柠檬酸和柠檬酸钠调节PH到5.5-7.3；
⑦冷却至37℃，过滤出料；
⑧检验合格后，分装、包装，再检验，成品入库。
对比例1-13
按照表2准备沐浴露各组分。
表2 对比例1-13沐浴露配方表
(续)表2 对比例1-13配方表
对比例1-13的制备方法与实施例1-3相同。
对比例1-13制备得沐浴露4-16。
对比例1：与实施例1不同之处在于对比例1没有包含植物提取物组合物；
对比例2：与实施例1不同之处在于对比例2没有包含春榆提取物；
对比例3：与实施例1不同之处在于对比例3没有包含甘草提取物；
对比例4：与实施例1不同之处在于对比例4没有包含葡糖柚提取物；
对比例5：与实施例1不同之处在于对比例5没有包含莼菜提取物；
对比例6：与实施例1不同之处在于对比例6没有包含桂竹汁提取物；
对比例7：与实施例1不同之处在于对比例7没有包含油脂；
对比例8：与实施例1不同之处在于对比例8没有包含皮肤调理剂；
对比例9：与实施例1不同之处在于对比例9包含的表面活性剂总量超出所述的范围；
对比例10：与实施例1不同之处在于对比例10包含的表面活性剂总量超出所述的范围；
对比例11：与实施例1不同之处在于对比例11没有包含两性表面活性剂；
对比例12：与实施例1不同之处在于对比例12没有包含非离子表面活性剂；
对比例13：与实施例1不同之处在于对比例13没有包含阴离子表面活性剂。
功效性测试
人体斑贴试验
1.受试物：本发明实施例1-3沐浴露、对比例1-13的沐浴露；
2.受试者：共120人，其中男70名，女50名，年龄20-55岁，符合受试者志愿入选标准；
3.试验方法：采用封闭式试验方法，将受试物置于合适的斑贴试器内，将其用低致敏胶带贴敷于受试者的手臂曲侧，用手掌轻压使之均匀的贴敷于皮肤上，持续24h；空白对照组为受试者不使用产品；
4.观察结果：分别在24小时后去除受试器，0.5h、24h、48h后观察皮肤反应，记录反应结果。皮肤的不良反应等级见表3，试验结果见表4。
表3 皮肤封闭型斑贴试验皮肤反应分级标准
表4 人体皮肤斑贴试验结果
结果表明，120例受试者中，实施例1、实施例2、实施例3、对比例2、对比例3、对比例4、对比例5、对比例6、对比例7、对比例8、对比例9、对比例10、对比例11、对比例12、对比例13有0例出现皮肤不良反应，对比例1有2例1级不良反应，对比例9有1例1级不良反应和1例2级不良反应，对比例10有1例1级不良反应，对比例11有1例1级不良反应，对比例12有1例1级不良反应。
实施例1、实施例2、实施例3与对比例1相比，实施例1、实施例2、实施例3无不良反应，对比例1有2例1级不良反应，通过添加植物组合物的沐浴露配方更加的温和。
实施例1、实施例2、实施例3与对比例9、对比例10相比，实施例1、实施例2、实施例3无不良反应，对比例9有1例1级不良反应和1例2级不良反应，对比例10有1例1级不良反应，说明超出剂量的表面活性剂的沐浴露配方会引起皮肤的刺激性。
实施例1、实施例2、实施例3与对比例11、对比例12相比，实施例1、实施例2、实施例3无不良反应，对比例11有1例1级不良反应，对比例12有1例1级不良反应，说明添加两性离子表面活性剂和非离子表面活性剂可以降刺激。
说明本发明实施例1-3的沐浴露安全无刺激，这种抗干敏沐浴露可以对皮肤安全、温 和。
性能测试
防腐挑战实验
防腐挑战实验(按照欧洲药典(EP7.0)的方法进行实验，测试结果如下表5所示)。
表5 防腐挑战实验
由表3可以看出，本发明实施例1-3沐浴露，通过了防腐挑战测试，模拟化妆品生产和使用过程中受到的微生物污染，从而避免消费者在使用产品过程中可能造成的伤害，结果表明氨基酸沐浴露的安全性。
人体感官评价
招募340名志愿者，经过入组后，随机分组，每组为20个志愿者持续使用各组沐浴露8周，测试者根据使用感受进行评分。评分标准采用7分制，1分为最差，7分为最好，分数越高越好。最终得出结果如表6所示。
表6
由表6可以得出，本发明的沐浴露组合物，在使用后容易冲洗干净、使用后皮肤的保湿度、抗瘙痒、鳞屑改善等方面，与市售氨基酸沐浴露A相比较，有较大的优势。普遍受到测试者的喜爱。
对比例1、对比例2、对比例3、对比例4、对比例5、对比例6与实施例1不同之处在于植物提取物组合物的不同，沐浴露使用后在抗瘙痒、鳞屑改善、消费者满意度等方面的使用效果都较差。
对比例7、对比例8与实施例1不同之处在于，没有包含油脂与皮肤调理剂，沐浴露使用后在保湿等方面的评分都较差。
对比例9、对比例10与实施例1不同之处在于，表面活性剂使用剂量超过推荐范围，沐浴露使用后，虽然泡沫的方面有改善，但因为过度脱脂，导致沐浴露使用后，鳞屑改善、抗瘙痒以及整体满意度等方面的表现较差。
对比例11、对比例12与实施例1不同之处在于，没有包含两性表面活性剂与非离子表面活性剂，沐浴露使用后，泡沫的绵密程度、沐浴露外观喜好度以及整体沐浴露满意等方面的评分较差。
对比例13与实施例1不同之处在于，没有包含阴离子表面活性剂，沐浴露使用后，泡沫的绵密程度、皮肤的干净程度以及整体满意度等方面评分较差。
以上结果说明，本发明的氨基酸沐浴露使用感较好，具有保湿、抗瘙痒、鳞屑改善等功效，且本沐浴露配方中几个组分之间具有协同增效的作用，整体使用效果较好。
以上详细描述了本发明的较佳具体实施例，是发明人花费了大量人力财力和时间，在多次试验得出来的结果，应当理解，本领域的普通技术无需创造性劳动就可以根据本发明的构思做出诸多修改和变化。
Claims (10)
- 一种植物提取物组合物，其特征在于，包括以重量百分比计以下组分：春榆提取物为0.1-30％，甘草提取物为0.05-45％，葡萄柚提取物为0.01-26％，莼菜提取物为0.05-20％，桂竹汁提取物为0.02-35％。
- 一种组合物，其特征在于，包括以重量百分比计的以下组分：阴离子表面活性剂10-40％，非离子表面活性剂1-12％，两性离子表面活性剂1-28％，如权利要求1所述的植物提取物组合物0.5-40％，油脂0.5-35％，皮肤调理剂0.1-6％。
- 如权利要求2所述的组合物，其特征在于，所述阴离子表面活性剂选自月桂酰肌氨酸钠、月桂酰丙氨酸钠、月桂酰谷氨酸钠、月桂酰燕麦氨基酸钠、椰油酰苹果氨基酸钠或椰油酰甲基牛磺酸牛磺酸钠中的至少一种；优选地，所述阴离子表面活性剂选自以重量百分比计的以下组分：月桂酰肌氨酸钠3-30％，优选6-20％；月桂酰丙氨酸钠0.5-10％，优选1-7％；月桂酰谷氨酸钠0.1-9％，优选0.5-6％；月桂酰燕麦氨基酸钠0.2-11％，优选0.5-8％；椰油酰苹果氨基酸钠0.5-12％，优选1-5％；椰油酰甲基牛磺酸牛磺酸钠1-12％，优选3-8％。
- 如权利要求2-3任一所述的组合物，其特征在于，所述非离子表面活性剂选自椰油酰胺MEA或椰油酰胺甲基MEA中的至少一种；优选地，所述非离子表面活性剂选自以重量百分比计的以下组分：椰油酰胺MEA 0.1-5％，优选0.5-2％；椰油酰胺甲基MEA0.2-6％，优选0.6-3％。
- 如权利要求2-4任一所述的组合物，其特征在于，所述两性离子表面活性剂选自椰油酰胺丙基甜菜碱、月桂酰两性乙酸钠或月桂酰羟基磺基甜菜碱中的至少一种；优选地，所述两性离子表面活性剂选自以重量百分比计的以下组分：椰油酰胺丙基甜菜碱0.5-25％，优选1-20％；月桂酰两性乙酸钠0.3-13％，优选0.4-12％；月桂酰羟基磺基甜菜碱0.1-23％，优选0.3-9％。
- 如权利要求2-5任一所述的组合物，其特征在于，所述植物提取物组合物选自以重量百分比计的以下组分：春榆提取物0.1-20％，优选0.5-15％；甘草提取物0.1-16％，优选0.3-15％；葡萄柚提取物0.2-8％，优选0.5-6％；莼菜提取物0.03-17％，优选0.1-11％；桂竹汁提取物0.03-5％，优选0.2-4％。
- 如权利要求2-6任一所述的组合物，其特征在于，所述油脂选自PEG-7甘油椰油酸酯、异硬脂酸或甘油月桂酸酯中的至少一种；优选地，所述油脂选自以重量百分比计的以下组分：PEG-7甘油椰油酸酯0.1-4％，优选0.2-1％；异硬脂酸0.1-2％，优选0.2-1％；甘油月桂酸酯0.1-5％，优选0.2-3％。
- 如权利要求2-7任一所述的组合物，其特征在于，所述皮肤调理剂选自聚季铵盐-7或聚季铵盐10中的至少一种；优选地，所述皮肤调理剂选自以重量百分比计的以下组分聚季铵盐-7 0.05-1％，优选0.1-0.6％，聚季铵盐10 0.01-2％，优选0.1-0.6％。
- 如权利要求2-8任一所述的组合物，其特征在于，还包括防腐剂、螯合剂、pH调节剂、香精或水中的一种或多种；优选地，所述防腐剂选自苯氧乙醇、乙基己基甘油或对羟基苯乙酮中的至少一种；优选地，所述防腐剂选自以重量百分比计的以下组分：苯氧乙醇0.2-1％，优选0.3-0.6％，乙基己基甘油0.1-1％，优选0.2-0.6％，对羟基苯乙酮0.1-1％，优选0.2-0.5％；优选地，所述螯合剂选自EDTA-2Na；优选地，所述螯合剂的重量百分比为0.1-0.6％，优选0.2-0.4％；优选地，所述pH调节剂选自柠檬酸、柠檬酸钠、氨甲基丙醇或三乙醇胺中的至少一种；优选地，所述pH调节剂选自柠檬酸；进一步优选柠檬酸的重量百分比为0.01-8％；优选地，所述香精的重量百分比为0.02％。
- 如权利要求9所述的组合的制备方法，其特征在于，包括以下步骤：1)将阴离子表面活性剂和水加入反应釜中，搅拌，加热75-80℃；2)加入两性离子表面活性，搅拌均匀；3)再加入非离子表面活性剂，螯合剂，搅拌均匀，保温20-30min降温；4)降温到45℃，加入植物组合物，防腐剂，油脂，搅拌均匀；5)加入皮肤调理剂、香精，调节pH到5.5-7.3；6)冷却至37℃，过滤。
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| Publication number | Publication date |
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| EP4023209A1 (en) | 2022-07-06 |
| EP4023209A4 (en) | 2023-12-27 |
| CN111671700A (zh) | 2020-09-18 |
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