WO2021206757A1 - Capsule de dissolution pour la désinfection des mains - Google Patents

Capsule de dissolution pour la désinfection des mains Download PDF

Info

Publication number
WO2021206757A1
WO2021206757A1 PCT/US2020/061807 US2020061807W WO2021206757A1 WO 2021206757 A1 WO2021206757 A1 WO 2021206757A1 US 2020061807 W US2020061807 W US 2020061807W WO 2021206757 A1 WO2021206757 A1 WO 2021206757A1
Authority
WO
WIPO (PCT)
Prior art keywords
capsule
dissolving
dissolving capsule
essential oil
outer shell
Prior art date
Application number
PCT/US2020/061807
Other languages
English (en)
Inventor
Moran Aviv
Guy MESCHIANY
Jonathan SHACHAR
Original Assignee
S.Y. Calimero Entrepreneurship Ltd
M&B IP Analysts, LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by S.Y. Calimero Entrepreneurship Ltd, M&B IP Analysts, LLC filed Critical S.Y. Calimero Entrepreneurship Ltd
Publication of WO2021206757A1 publication Critical patent/WO2021206757A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01P—BIOCIDAL, PEST REPELLANT, PEST ATTRACTANT OR PLANT GROWTH REGULATORY ACTIVITY OF CHEMICAL COMPOUNDS OR PREPARATIONS
    • A01P1/00—Disinfectants; Antimicrobial compounds or mixtures thereof
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
    • A01N25/26—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests in coated particulate form
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D65/00—Wrappers or flexible covers; Packaging materials of special type or form
    • B65D65/38—Packaging materials of special type or form
    • B65D65/46—Applications of disintegrable, dissolvable or edible materials

Definitions

  • the disclosure generally relates to a single-use hand sanitizing capsule and, particularly, to encapsulation of a sanitizing solution therein.
  • dispensers are deficient in that they require that the user physically touch the dispenser for the purpose of dispensing the sanitizing materials.
  • Some dispensers are automatic and sense the presence of the hands and dispense the sanitizing materials.
  • such dispensers are dependent on the availability of energy, for example, electricity, for proper operation.
  • Certain embodiments disclosed herein include a dissolving capsule, the dissolving capsule comprising a sanitizing substance; and an outer shell encapsulating therein the sanitizing substance, wherein the outer shell is adapted to collapse upon applying at least a predetermined amount of force thereupon, and wherein the outer shell dissolves upon coming into contact with the sanitizing substance.
  • FIG. 1 is an illustration of a cross-sectional view of a hand sanitizing dissolving capsule in accordance with an embodiment.
  • FIG. 2 is an illustration of a human hand squeezing a hand sanitizing dissolving capsule in accordance with an embodiment.
  • FIG. 3 is a schematic illustration of a cross-sectional view of a hand sanitizing dissolving capsule under pressure in accordance with an embodiment.
  • Fig. 4A is a schematic illustration of a three-dimensional view of a dissolving capsule comprising a plurality of notch lines in the outer shell.
  • Fig. 4B is a schematic illustration of a three-dimensional view of a dissolving capsule comprising a plurality of notch points in the outer shell.
  • Some example embodiments include a single-use hand sanitizer dissolving capsule.
  • the example disclosed capsule has an outer shell that is crushed upon use by a human wishing to perform a sanitization such as, for example, sanitization of the hand.
  • the material of the outer shell is adapted to dissolve upon use, reducing waste and costs and increasing usability.
  • the outer shell encapsulates therein a sanitizing substance which, once the dissolving capsule is crushed, provides the desired sanitization effect.
  • the capsule may further contain substances that accelerate the dissolving of the crushed outer shell.
  • a barrier layer separates the outer shell and the sanitization substance, thereby preventing any chemical interaction therebetween.
  • the barrier layer may include moisturizing substances to moisturize the hands of a user of the dissolving capsule.
  • Fig. 1 is an example schematic illustration of a cross-sectional view of a dissolving capsule 100 according to an embodiment.
  • the dissolving capsule 100 may be a sphere-shaped capsule having a width (w1) and a volume (v1).
  • a dissolving capsule 100 has such a configuration, wherein the width (w1 ) ranges from 1 cm to 2cm, and wherein the volume (v1 ) ranges from 0.5ml_ to 4.2 ml_.
  • dissolving capsule 100 may be shaped as, without limitation, a sphere, a cylinder, a cone, a cube, a disc, or any other three dimensional (3D) geometric shape.
  • the dissolving capsule 100 includes an outer shell 130 that encapsulates therein a sanitizing substance 110.
  • the dissolving capsule 100 is structured with a barrier layer 120 that separates the outer shell 130 and the sanitizing substance 110, as further explained herein.
  • the sanitizing substance 110 includes a sanitizing solution aimed to kill or otherwise neutralize most microorganisms found on, for example, the skin of the hands of a human.
  • the composition of the sanitizing substance 110 that is contained within the outer shell 130, or at least one active ingredient thereof includes, but is not limited to, one or more of the following disinfectants; alcohol (such as ethanol and isopropanol), aldehydes such as glutaraldehyde, anilides, biguanides such as chlorhexidine, diamidines, halogen-releasing agents, silver compounds, peroxygens such as hydrogen peroxide, phenols, bis-phenols, halophenols, and quaternary ammonium compounds such as benzalkonium chloride.
  • the sanitizing substance 110 may further include sodium citrate (typically up to 40% by volume).
  • the sanitizing substance 110 may be, for example, a liquid or a gel-phase.
  • the volume of the sanitizing substance 110 is within the range of 0.25ml-2.2ml.
  • scent emitting substances e.g., fragrant formulations or aromatic compositions
  • Scent emitting substances may be based on essential oils which may have a scent and additionally possess antiseptic and antimicrobial properties.
  • the scent emitting substance may include, but is not limited to, one or more of the following essential oils: clove essential oil, which contains 90% eugenol and has known efficacy on common bacteria on the skin, such as E.Coli and S. Aureus, peppermint essential oil, aloe vera gel, lavender essential oil, lemon essential oil, and witch hazel essential oil.
  • the barrier layer 120 serves as a barrier between the sanitizing substance 110 and outer shell 130.
  • the barrier layer 120 is further used to protect the integrity of the dissolving capsule before use.
  • the materials used for the barrier layer 120 may contain one or more moisturizing substances, such as those moisturizing substances described hereinbelow, to provide moisturization of the hand when the dissolving capsule 100 is used as discussed herein.
  • the barrier layer 120 includes moisturizing substances such as, without limitation, glycerol, silicone oil, paraffin oil, essential oil, or combinations thereof.
  • the barrier layer 120 creates a barrier between the sanitization substance 110 and the outer shell 130, thus preventing premature contact prior to use.
  • the barrier layer 120 provides moisturization when in contact with skin.
  • the thickness of the barrier layer 120 ranges from 10 pm to 1000pm.
  • the outer shell 130 is a film that includes a step-growth polymer which dissolves, for example, when it comes into contact with at least some of the contents of the sanitizing substance 110.
  • the polymer used for the outer shell 130 includes, but is not limited to, calcium-alginate, which is biocompatible, inexpensive, and degrades upon contact with sodium citrate solution which may be contained in the sanitizing substance 110.
  • the outer shell 130 includes polyesters, polyamides, polycarbonates or combinations thereof.
  • step-growth polymers which may be used include, without limitation, various alginates, polyesters, polyamides, methyl- derivative polymers, ethyl-derivative polymers, polymethyl methacrylate (PMMA), polyethylene glycol (PEG), polyacrylic acid, and the like, as well as any combination thereof.
  • applicable polyesters include, without limitation, polyethylene glycol polyester, aliphatic homopolymers, such as polylactic acid (PLA), aliphatic copolymers such as polylactic-co-glycolic acid (PLGA), and the like, as well as any combination thereof.
  • alginate polymers such as alginate
  • a cross-linking calcium solution such as calcium lactate or calcium chloride.
  • a calcium-linked alginate polymer is more chemically, thermally, and mechanically stable than native alginate polymers.
  • the polymer used for the outer shell 130 is polyester, polyethylene glycol (PEG), and the like, as well as various combinations and copolymers thereof, such as, as an example, and without limitation, Syntonav SR300, a polyester which is sensitive to 70% ethanol and which rapidly breaks down in the presence of 70% ethanol. In this embodiment, sodium citrate would not be added to the sanitizing substance 110. In an embodiment, the thickness of the outer shell 130 ranges from 10pm to 1000pm. Syntonav SR300 is chemically known as polyethylene glycol polyester, (CioHi206(C2H40)nH20)x.
  • CAS number is 9016- 88-0, and it is also referred to also as 1 ,4-Benzenedicarboxylic Acid, Polymer with 1 ,2-Ethanediol and alpha-Hydro-omega-Hydroxypropyl(Oxy-1 ,2-Ethanediyl).
  • a typical final concentration may be 15-50% in water.
  • the outer shell 130, the barrier layer 120, and the sanitizing substance 110 contain surfactant material to stabilize and strengthen bonding therebetween.
  • the surfactant used may be, but is not limited to, Sorbitan monostearate, Tween 20, Tween 80, Polyethlene Glycol (PEG), Lecitine, or combinations thereof.
  • any combination of one or more surfactant may be present in order to create a stronger chemical bond between the layers and to increase the chemical stability of the dissolving capsule.
  • the dissolving capsule 100 is adapted, therefore, to be moisture-resistant and stable in temperatures up to 80°C.
  • the sanitizing substance 110 is adapted to maintain efficacy for at least a desired period of time following manufacture.
  • the outer shell 130 consists of polyester or a copolymer consisting of polyester and a second polymer, such as PEG, the barrier layer consists of glycerol, and the sanitizing substance 110 consists of alcohol.
  • the outer shell 130 includes a polyamide
  • the barrier layer 120 includes silicon oil
  • the sanitizing substance 110 includes aldehydes.
  • the outer shell 130 includes methyl- or ethyl-derivative polymers
  • the barrier layer 120 includes paraffin oil
  • the sanitizing substance 110 includes anilides.
  • the sanitizing substance 110 may contain therein microbeads of sodium citrate while the outer shell 130 is made of calcium- alginate. Such a case would not require the use of the barrier layer 120.
  • FIG. 2 is an example schematic illustration of a human hand 200 squeezing the dissolving capsule 100 in accordance with an embodiment.
  • a human hand either one hand or both hands, applies pressure to the capsule by squeezing it.
  • the pressure applied causes the outer shell 130 to crack, rupture, or otherwise disintegrate, resulting in the sanitizing substance 110 reaching the human hands, as well as engaging with the outer shell 130.
  • a process of dissolving of the outer shell 130 begins until such a time that the entire material that comprised the outer shell 130 dissolves.
  • FIG. 3 is a schematic illustration of a cross-sectional view of a hand sanitizing dissolving capsule 100 under pressure in accordance with an embodiment.
  • pressure (arrows 320) is applied on the capsule 100 on a plurality of rupture points 330-n, where ‘n’ is an integer equal to or greater than ⁇ .’
  • the outer shell 130 ruptures.
  • the outer shell 130 degrades and dissolves.
  • the sanitizing substance 110 is no longer encapsulated by the outer shell 130 and freely flows (arrows 340).
  • the user rubs the entire composition over the surface area of the user’s hands, sanitizing the hands with the sanitizing substance 110.
  • the user rubs hands until the outer shell 130 fully dissolves into the sanitizing substance 110.
  • the rubbing of the composition over the user’s hands further includes moisturization of the user’s hands by the barrier layer 120, which provides moisturization.
  • Fig. 4A is an example three-dimensional illustration of a dissolving capsule 100 according to an embodiment.
  • the dissolving capsule 100 includes a plurality of notch lines 410 in the outer shell 130 of the capsule.
  • the capsule 100 has at least one notch line 410 in the outer shell 130, which allows the dissolving capsule 100 to rupture more easily when pressure is applied.
  • the notch lines 410 which are like slight abrasions upon the surface of the outer shell 130, are mechanically weaker, allowing the capsule to rupture when pressure is applied.
  • notch lines 410 may cross each other, for example, but not by way of limitation, as longitude and latitude lines.
  • Fig. 4B is an example three-dimensional illustration of a dissolving capsule 100 further comprising a plurality of notch points 420 in the outer shell 130 of the dissolving capsule 100.
  • dots are used to create notch points 420 where the surface of the outer shell is weaker and, therefore, more likely to rupture upon the application of pressure.
  • the scratch-like notches should not penetrate the outer shell 130 width, so that neither the sanitizing substance 110 nor the barrier layer 120 is exposed thereby.
  • notch points may be used. That is, some of the notch points may be notch lines and others may be notch dots.
  • one or more colors may be used in any one of sanitizing substance 110, barrier layer 120, and/or the outer shell 130 to provide any desired coloring effect.
  • logos, text, and/or other images may be embossed or carved in the outer shell 130, or otherwise appear as part of the dissolving capsule, without departing from the scope of the invention.
  • any reference to an element herein using a designation such as “first,” “second,” and so forth does not generally limit the quantity or order of those elements. Rather, these designations are generally used herein as a convenient method of distinguishing between two or more elements or instances of an element. Thus, a reference to first and second elements does not mean that only two elements may be employed there or that the first element must precede the second element in some manner. Also, unless stated otherwise, a set of elements comprises one or more elements.
  • the phrase “at least one of” followed by a listing of items means that any of the listed items can be utilized individually, or any combination of two or more of the listed items can be utilized. For example, if a system is described as including “at least one of A, B, and C,” the system can include A alone; B alone; C alone; 2A; 2B; 2C; 3A; A and B in combination; B and C in combination; A and C in combination; A, B, and C in combination; 2A and C in combination; A, 3B, and 2C in combination; and the like.

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Environmental Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Agronomy & Crop Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Toxicology (AREA)
  • Dentistry (AREA)
  • Mechanical Engineering (AREA)
  • Cosmetics (AREA)

Abstract

L'invention concerne une capsule de dissolution pour la désinfection des mains. La dissolution comprend une substance désinfectante; et une coque externe encapsulant la substance désinfectante, la coque externe étant conçue pour s'affaisser lors de l'application d'au moins une quantité prédéterminée de force sur celle-ci, et la coque externe se dissolvant lorsqu'elle est en contact avec la substance désinfectante.
PCT/US2020/061807 2020-04-07 2020-11-23 Capsule de dissolution pour la désinfection des mains WO2021206757A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202063006439P 2020-04-07 2020-04-07
US63/006,439 2020-04-07

Publications (1)

Publication Number Publication Date
WO2021206757A1 true WO2021206757A1 (fr) 2021-10-14

Family

ID=78023542

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2020/061807 WO2021206757A1 (fr) 2020-04-07 2020-11-23 Capsule de dissolution pour la désinfection des mains

Country Status (1)

Country Link
WO (1) WO2021206757A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2786973C1 (ru) * 2022-05-17 2022-12-26 Татьяна Павловна Сатаева Антибактериальное средство для обработки рук

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050281757A1 (en) * 2004-06-17 2005-12-22 Sayed Ibrahim Oral care film
RU2277425C2 (ru) * 2004-02-11 2006-06-10 Елена Борисовна Иванова Твердая дозированная форма дезинфицирующего средства, упаковка с ней, способ дезинфекции
WO2011045706A1 (fr) * 2009-10-14 2011-04-21 Firmenich Sa Capsules solides comprenant de l'éthanol, un glucide, un sel et un revêtement produit par un agent de poudrage, procédé de préparation desdites capsules par séchage par pulvérisation
DE102013016553A1 (de) * 2013-10-04 2015-04-09 Dave Trupti Gekerbte Einwegkapsel bestehend aus Polyvinylalkohl (PVA) oder einem PVA-Kopolymeren enthaltend eine Handdesinfektionsmittelzubereitung
US20150264921A1 (en) * 2003-05-11 2015-09-24 Ben-Gurion University Of The Negev Research And Development Authority Encapsulated Essential Oils
WO2019083397A1 (fr) * 2017-10-23 2019-05-02 Общество С Ограниченной Ответственностью "Сан Системз" Solubilisation de la base de chlorhexidine, compositions antiseptique et désinfectante

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20150264921A1 (en) * 2003-05-11 2015-09-24 Ben-Gurion University Of The Negev Research And Development Authority Encapsulated Essential Oils
RU2277425C2 (ru) * 2004-02-11 2006-06-10 Елена Борисовна Иванова Твердая дозированная форма дезинфицирующего средства, упаковка с ней, способ дезинфекции
US20050281757A1 (en) * 2004-06-17 2005-12-22 Sayed Ibrahim Oral care film
WO2011045706A1 (fr) * 2009-10-14 2011-04-21 Firmenich Sa Capsules solides comprenant de l'éthanol, un glucide, un sel et un revêtement produit par un agent de poudrage, procédé de préparation desdites capsules par séchage par pulvérisation
DE102013016553A1 (de) * 2013-10-04 2015-04-09 Dave Trupti Gekerbte Einwegkapsel bestehend aus Polyvinylalkohl (PVA) oder einem PVA-Kopolymeren enthaltend eine Handdesinfektionsmittelzubereitung
WO2019083397A1 (fr) * 2017-10-23 2019-05-02 Общество С Ограниченной Ответственностью "Сан Системз" Solubilisation de la base de chlorhexidine, compositions antiseptique et désinfectante

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
TVERDYE KAPSULY: "istoriya postoyannykh izmeneny i usovershenstvovany", FARMATSEVTICHESKAYA OTRASL, vol. 2, no. 37, 2013, pages 31 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2786973C1 (ru) * 2022-05-17 2022-12-26 Татьяна Павловна Сатаева Антибактериальное средство для обработки рук

Similar Documents

Publication Publication Date Title
Todd et al. Outbreaks where food workers have been implicated in the spread of foodborne disease. Part 10. Alcohol-based antiseptics for hand disinfection and a comparison of their effectiveness with soaps
US8343525B2 (en) Chlorhexidine acetate antiseptic cleaning agent
US4678658A (en) Aerosol germicide and dye
US4793988A (en) Germicide and dye composition
US20140057987A1 (en) Disinfectant Spray with Indicator
AU695346B2 (en) Non-toxic hypocompatible biodegradable germicide
CN102905683A (zh) 皮肤处理组合物
Dastider et al. Hand sanitizers bid farewell to germs on surface area of hands
US6833340B2 (en) System for delivery of active substances
US20230093881A1 (en) Hand sanitizer and method of making the same
JPH06279268A (ja) 消毒殺菌剤およびこれを含有するエアゾール組成物
JP2904917B2 (ja) 非毒性、非腐食性、生物分解性の消毒剤及び殺菌剤
US4990334A (en) Glycerol-chlorine matrix
WO2021206757A1 (fr) Capsule de dissolution pour la désinfection des mains
US20120018445A1 (en) Portable High Capacity Canister Anti-Microbial Towelette Dispenser
JPH072615A (ja) 抗菌性消毒剤含浸布
US9615573B1 (en) Product and method for providing anti-microbial delivery
Nyamwweya et al. Alcohol-Based hand sanitizers–A multidimensional perspective
KR102596259B1 (ko) 캡슐형 소독제
KR20080001851U (ko) 살균, 살 바이러스 기능과 피부 보호 기능을 가진 소독용티슈
WO1993016737A1 (fr) Germicide biodegradable
CA3132421A1 (fr) Miel pour blessures et distributeur a pompe
WO2021219422A1 (fr) Composition d'aérosol et procédé de désinfection
Gjorgjeska et al. Structure and physicochemical properties of antiseptics and disinfectants in relation to their activity
WO2021219358A1 (fr) Composition d'aérosol pour l'assainissement

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 20930138

Country of ref document: EP

Kind code of ref document: A1

NENP Non-entry into the national phase

Ref country code: DE

32PN Ep: public notification in the ep bulletin as address of the adressee cannot be established

Free format text: NOTING OF LOSS OF RIGHTS PURSUANT TO RULE 112(1) EPC (EPO FORM 1205A DATED 30/01/2023)

122 Ep: pct application non-entry in european phase

Ref document number: 20930138

Country of ref document: EP

Kind code of ref document: A1