WO2021201004A1 - 歯のホワイトニング及び歯質強化方法 - Google Patents

歯のホワイトニング及び歯質強化方法 Download PDF

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Publication number
WO2021201004A1
WO2021201004A1 PCT/JP2021/013639 JP2021013639W WO2021201004A1 WO 2021201004 A1 WO2021201004 A1 WO 2021201004A1 JP 2021013639 W JP2021013639 W JP 2021013639W WO 2021201004 A1 WO2021201004 A1 WO 2021201004A1
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WO
WIPO (PCT)
Prior art keywords
tooth
tooth surface
acid
teeth
whitening
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2021/013639
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English (en)
French (fr)
Japanese (ja)
Inventor
秀俊 西尾
尚子 三木
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nishio Co Ltd
Original Assignee
Nishio Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nishio Co Ltd filed Critical Nishio Co Ltd
Priority to JP2022512571A priority Critical patent/JP7802363B2/ja
Priority to US17/916,254 priority patent/US20230240824A1/en
Publication of WO2021201004A1 publication Critical patent/WO2021201004A1/ja
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
    • A61C19/00—Dental auxiliary appliances
    • A61C19/06—Implements for therapeutic treatment
    • A61C19/063—Medicament applicators for teeth or gums, e.g. treatment with fluorides
    • A61C19/066—Bleaching devices; Whitening agent applicators for teeth, e.g. trays or strips
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/194—Carboxylic acids, e.g. valproic acid having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/16—Fluorine compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/42—Phosphorus; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/20—Halogens; Compounds thereof
    • A61K8/21—Fluorides; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/24—Phosphorous; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36—Carboxylic acids; Salts or anhydrides thereof
    • A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67—Vitamins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses

Definitions

  • the present invention relates to a method for whitening teeth and strengthening tooth structure. More specifically, the present invention relates to a tooth whitening method and a tooth structure strengthening method in which a tooth surface is treated with an acid and then a tooth whitening using hydroxyapatite and a tooth structure strengthening by fluorine are used in combination.
  • Non-Patent Document 1 is a document that is the background of the whitening agent used in the present invention, and describes the properties of hydroxyapatite, the action of saliva, and the like with respect to hydroxyapatite. However, this document does not describe the whitening agent used in the present invention.
  • tooth surface application As a conventional method of strengthening the tooth structure. Tooth enamel is composed of 97% hydroxyapatite, 2% organic and 1% water, the maturity of the hydroxyapatite crystals varies, and a wide variety of lattice defects are present.
  • fluorine acts on hydroxyapatite
  • the composition of hydroxyapatite changes to fluoroapatite.
  • This fluoroapatite shrinks its morphology as a structure and increases the strength of its crystal structure, thereby improving acid resistance.
  • the action of making the teeth difficult to dissolve even when exposed to the acid of caries bacteria was used as a method of strengthening the tooth structure.
  • the harmful effects of fluorine may cause many harmful systemic symptoms such as IQ reduction due to regular use of fluorine, induction of autism, and induction of atopic dermatitis.
  • the conventional "fluorine tooth surface application” is applied to the tooth surface as it is, but it is called “pellicle” which takes in a coloring component made of protein on the tooth surface and causes yellowing of the tooth. Since a thin organic film is attached, it is necessary to remove coloring components and pellicle, repair and remineralize the tooth structure, and then apply the action of strengthening the tooth structure without exciting harmful symptoms to the whole body.
  • a fluorine-containing dentifrice or a fluorine-containing gargle is not used because it has an absorption effect from the oral mucosa, and is applied only to the tooth surface and wiped off so as not to touch the mucous membrane.
  • leftovers from daily meals and toothpaste are added, and the surface of the teeth is covered with multiple layers of dirt. On top of that, people apply fluoride mouthwashes and fluoride coatings, which reduces the effectiveness of the efficiency effect.
  • the present invention divides the chemical reaction on the tooth surface into three stages of time series and performs it in a series of flows to whiten the enamel on the tooth surface in removing color.
  • a tooth whitening and enamel strengthening method capable of enhancing a synergistic effect rather than individually performing tooth surface restoration, remineralization, and enamel strengthening.
  • an acidic solvent such as citric acid, acetic acid, phosphoric acid, malic acid, and ascorbic acid having a pH of 0.5 to 5.0 is applied to the tooth.
  • an acidic solvent such as citric acid, acetic acid, phosphoric acid, malic acid, and ascorbic acid having a pH of 0.5 to 5.0 is applied to the tooth.
  • dirt, tooth stones, coloring components and pellicle are removed from the tooth surface, and as the second stage treatment, hydroxyapatite dissolved in saliva or a solvent similar to saliva is applied to the tooth surface.
  • a three-step treatment a three-step treatment of applying a fluorine agent to the tooth surface is performed in order to remove colored stains and organic protein pellicle on the tooth surface and make the tooth surface components more effective. It is possible to calcify, restore the tooth surface and calcify, increase the whiteness of the tooth, increase the acid resistance of the tooth substance, and increase the strength of the tooth surface.
  • Tooth surface coloring components and pellicle are removed using an acidic solvent of citric acid, acetic acid, phosphoric acid, malic acid, and ascorbic acid having a pH of 0.5 to 5.0.
  • Hydroxyapatite particles having a particle size of 4 nm to 1.7 mm, which is a combination of calcium, calcium phosphate and hydroxide ions, are applied to the tooth surface in a state of being dissolved in saliva or a solvent similar to saliva. Effectively binds to the enamel apatite that composes, and enhances remineralization.
  • Fluorine is applied to calcium phosphate (apatite), which is a constituent of the tooth surface, to form calcium fluorophosphate (fluoroapatite), and the enamel apatite crystals on the tooth surface are shrunk to improve acid resistance. Strengthens the raised tooth structure.
  • a solvent that promotes the dissociation of the crystal structure of apatite crystals Ca 10 (PO 4 ) 6 (OH) 2 by applying a solvent with a high dissociation rate of apatite crystals dissolved in saliva or a solution of components similar to saliva to the tooth surface. Efficiently binds to the enamel (calcium phosphate) on the tooth surface to build a phenomenon of remineralization without damaging the tooth surface, and to thicken the enamel (calcium phosphate) to strengthen the tooth structure. It also causes the effect of repairing the unevenness of the tooth surface cleanly and flatly, and at the same time causes the effect of whitening the teeth.
  • an acidic solvent such as citric acid, acetic acid, phosphoric acid, malic acid, and ascorbic acid having a pH of 0.5 to 5.0 is applied, and a tooth surface coloring component and a pellicle are applied.
  • a tooth surface coloring component and a pellicle are applied.
  • the components of the tooth surface are more effectively calcified, and the tooth surface is restored and the tooth structure is strengthened.
  • a fluorine agent to the tooth surface, the acid resistance of the tooth substance is increased along with the whiteness of the tooth, and the strength of the tooth surface is increased.
  • the enamel on the surface is strengthened by the crystallization of hydroxyapatite, and the fluorine bond of the enamel strengthens the bondability of the crystal structure. Allows for strengthening.
  • the three-step treatment (treatment) of increasing is performed in this order.
  • the enamel on the tooth surface is strengthened by the crystallization of hydroxyapatite, and the fluorine bond of the enamel strengthens the bondability of the crystal structure. Enables enamel and enamel strengthening.
  • hydroxyapatite particles In the tooth whitening and tooth strengthening method of the present invention, a solvent obtained by dissolving hydroxyapatite having an average particle size of 4 nm to a maximum particle size of 1.7 mm, which is smaller than usual, in saliva or a solvent similar to saliva is used. ..
  • fluorine As the fluorine used in the tooth whitening and dentin strengthening method of the present invention, 500 ppm to 100,000 ppm of sodium fluoride, calcium fluoride and stannous fluoride are used.
  • FIG. 1 is a diagram showing an example of removing plaque, tooth stone, and pellicle with citric acid of pH 2.5
  • FIG. 1 (a) shows the state of the tooth surface before applying citric acid of pH 2.5
  • FIG. (B) is a photograph showing the state of the tooth surface 5 minutes after applying citric acid having a pH of 2.5 to the tooth surface. As shown in the figure, it can be seen that plaque, tartar, and pellicle adhering to the tooth surface are cleanly removed by applying citric acid having a pH of 2.5 to the tooth surface.
  • FIG. 2 by applying 4 nm to 1.7 mm hydroxyapatite particles dissolved in saliva or a solvent similar to saliva to the tooth surface, it is combined with the apatite constituting the tooth surface, and the tooth surface is restored and the apatite is regenerated.
  • FIG. 6A is a photograph showing the state of the tooth surface before control (before application)
  • FIG. 9B is a 100 nm hydroxyapatite particle on the rough surface of artificial enamel. It is a photograph which shows the state of the tooth surface 5 minutes after application. As shown in the figure, it can be seen that the tooth surface is restored and the apatite is reconstructed by binding with the apatite constituting the tooth surface.
  • FIG. 3 is a diagram showing enamel strengthening due to enamel contraction by applying 9,000 ppm sodium fluoride to the tooth surface
  • FIG. 3A is a photograph showing the state of the tooth surface before application
  • FIG. 3B is a photograph showing the state of the tooth surface 1 minute after application of 9,000 ppm sodium fluoride.
  • shrinkage of apatite crystals on the tooth surface due to the application of sodium fluoride is observed.
  • the tooth whitening and tooth strengthening method of the present invention can provide a tooth whitening method including aesthetic tooth whitening. Therefore, the present invention can be used not only for medical purposes but also as a method for whitening teeth and strengthening tooth structure performed for cosmetic purposes in whitening salons, dental offices, etc. that are not medical institutions.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Birds (AREA)
  • Inorganic Chemistry (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Dentistry (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Emergency Medicine (AREA)
  • Cosmetics (AREA)
PCT/JP2021/013639 2020-03-30 2021-03-30 歯のホワイトニング及び歯質強化方法 Ceased WO2021201004A1 (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2022512571A JP7802363B2 (ja) 2020-03-30 2021-03-30 歯のホワイトニング及び歯質強化方法
US17/916,254 US20230240824A1 (en) 2020-03-30 2021-03-30 Tooth Whitening and Tooth Strengthening Method

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2020-061676 2020-03-30
JP2020061676 2020-03-30
JP2020-066330 2020-04-01
JP2020066330 2020-04-01

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WO2021201004A1 true WO2021201004A1 (ja) 2021-10-07

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US (1) US20230240824A1 (https=)
JP (1) JP7802363B2 (https=)
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Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5673015A (en) * 1979-11-15 1981-06-17 Dentaru Kagaku Kk Toothpaste composition
JPH0368442A (ja) * 1989-05-31 1991-03-25 Kao Corp フッ化物コロイド液
JPH08143436A (ja) * 1994-11-21 1996-06-04 Kazue Yamagishi 歯の漂白剤及びこの漂白剤を用いた歯の漂白方法
JP2002167318A (ja) * 2000-11-30 2002-06-11 Lion Corp 固体口腔用組成物
JP2005047903A (ja) * 2003-07-15 2005-02-24 Kao Corp 口腔用組成物
JP2005139201A (ja) * 2002-11-19 2005-06-02 Showa Yakuhin Kako Kk 歯石及びウ蝕部溶解剤
JP2007504186A (ja) * 2003-09-01 2007-03-01 ヘンケル・コマンディットゲゼルシャフト・アウフ・アクチエン 口腔および歯衛生製剤
JP2008231032A (ja) * 2007-03-20 2008-10-02 Sangi Co Ltd 改良３ｄｓホームケア剤及びう蝕、歯周病、日和見感染菌除菌システム
JP2009528352A (ja) * 2006-03-01 2009-08-06 デンテック インコーポレイテッド 口腔衛生製品とその使用法
JP2017048162A (ja) * 2015-09-04 2017-03-09 ライオン株式会社 口腔用組成物

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5098303A (en) * 1990-03-22 1992-03-24 Ultradent Products, Inc. Method for bleaching teeth
US5855870A (en) * 1990-03-22 1999-01-05 Ultradent Products, Inc. Method for treating sensitive teeth
US6306370B1 (en) * 1997-05-30 2001-10-23 Ultradent Products, Inc. Compositions and methods for whitening and desensitizing teeth
EP1855609A4 (en) * 2004-09-29 2009-08-12 Rejuvedent Llc METHOD AND APPARATUS FOR DENTAL REJUVENATION AND MODIFICATION OF HARD TISSUE
US20080280260A1 (en) * 2004-09-29 2008-11-13 Belikov Andrei V Method and Apparatus for Tooth Rejuvenation and Hard Tissue Modification
US20080057007A1 (en) * 2006-03-01 2008-03-06 Dentech, Inc. Oral hygiene products containing ascorbic acid and method of using the same
WO2008067334A2 (en) * 2006-11-27 2008-06-05 Rejuvedent Llc A method and apparatus for hard tissue treatment and modification
CN107743386A (zh) * 2015-06-05 2018-02-27 荷兰联合利华有限公司 口腔护理装置
US20190175956A1 (en) * 2017-07-19 2019-06-13 David Dolezal Oral care products and formulations
WO2019102354A1 (en) * 2017-11-21 2019-05-31 3M Innovative Properties Company Oral plant-based-oil-in-water emulsions and methods of use

Patent Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5673015A (en) * 1979-11-15 1981-06-17 Dentaru Kagaku Kk Toothpaste composition
JPH0368442A (ja) * 1989-05-31 1991-03-25 Kao Corp フッ化物コロイド液
JPH08143436A (ja) * 1994-11-21 1996-06-04 Kazue Yamagishi 歯の漂白剤及びこの漂白剤を用いた歯の漂白方法
JP2002167318A (ja) * 2000-11-30 2002-06-11 Lion Corp 固体口腔用組成物
JP2005139201A (ja) * 2002-11-19 2005-06-02 Showa Yakuhin Kako Kk 歯石及びウ蝕部溶解剤
JP2005047903A (ja) * 2003-07-15 2005-02-24 Kao Corp 口腔用組成物
JP2007504186A (ja) * 2003-09-01 2007-03-01 ヘンケル・コマンディットゲゼルシャフト・アウフ・アクチエン 口腔および歯衛生製剤
JP2009528352A (ja) * 2006-03-01 2009-08-06 デンテック インコーポレイテッド 口腔衛生製品とその使用法
JP2008231032A (ja) * 2007-03-20 2008-10-02 Sangi Co Ltd 改良３ｄｓホームケア剤及びう蝕、歯周病、日和見感染菌除菌システム
JP2017048162A (ja) * 2015-09-04 2017-03-09 ライオン株式会社 口腔用組成物

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TW202202130A (zh) 2022-01-16
US20230240824A1 (en) 2023-08-03
JPWO2021201004A1 (https=) 2021-10-07
JP7802363B2 (ja) 2026-01-20
TWI854109B (zh) 2024-09-01

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