WO2021199079A1 - Composition pesticide synergique - Google Patents

Composition pesticide synergique Download PDF

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Publication number
WO2021199079A1
WO2021199079A1 PCT/IN2021/050326 IN2021050326W WO2021199079A1 WO 2021199079 A1 WO2021199079 A1 WO 2021199079A1 IN 2021050326 W IN2021050326 W IN 2021050326W WO 2021199079 A1 WO2021199079 A1 WO 2021199079A1
Authority
WO
WIPO (PCT)
Prior art keywords
composition
total weight
fungicide
range
amount
Prior art date
Application number
PCT/IN2021/050326
Other languages
English (en)
Inventor
Rao JAYPRAKASH GOPALKRISHNAN
Seema Patil
Bagle AVINASH VITTHAL
Mayur BORSE
Sachin VISHWAKARMA
Bhagat TANAJI SHIVAJI
Original Assignee
Indofil Industries Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Indofil Industries Limited filed Critical Indofil Industries Limited
Priority to BR112022013453A priority Critical patent/BR112022013453A2/pt
Publication of WO2021199079A1 publication Critical patent/WO2021199079A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/34—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom
    • A01N43/40—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom six-membered rings
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/64—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with three nitrogen atoms as the only ring hetero atoms
    • A01N43/647—Triazoles; Hydrogenated triazoles
    • A01N43/653—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
    • A01N47/08—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having one or more single bonds to nitrogen atoms
    • A01N47/10—Carbamic acid derivatives, i.e. containing the group —O—CO—N<; Thio analogues thereof
    • A01N47/12—Carbamic acid derivatives, i.e. containing the group —O—CO—N<; Thio analogues thereof containing a —O—CO—N< group, or a thio analogue thereof, neither directly attached to a ring nor the nitrogen atom being a member of a heterocyclic ring
    • A01N47/14—Di-thio analogues thereof

Definitions

  • the invention relates to a pesticidal composition, more particularly to a synergistic liquid pesticidal composition comprising two or more active ingredients.
  • the present invention in one aspect provides a liquid pesticidal composition.
  • the synergistic liquid composition comprises 32 to 80 wt% of a dithiocarbamate fungicide based on the total weight of the composition, 1 to 40 wt% of a strobilurin fungicide based on the total weight of the composition, 1 to 40 wt% of a conazole fungicide based on the total weight of the composition, an Additive blend comprising Acrylic Copolymer solution, sodium dodecyl sulfate and sodium naphthalene sulphonate condensate in the ratio of 2:1:2, and pre-determined amounts of at least one suitable agricultural excipient.
  • the present invention in another aspect discloses a process for preparing a synergistic pesticidal composition.
  • the process comprises blending at least one strobilurin fungicide, at least one conazole fungicide and additive blend to obtain a first mixture, diluting the first mixture with water to obtain premix slurry, passing the premix slurry through a bead mill to obtain a concentrate suspension of a particle size in a predetermined range and mixing the concentrate suspension with a dithiocarbamate fungicide, suitable agricultural excipients and predetermined quantity of water to obtain the pesticidal composition.
  • the present invention in one aspect, is directed towards a stable and synergistic liquid pesticidal composition.
  • the pesticidal composition is stable and active during long period of storage without degradation.
  • the synergistic liquid pesticidal composition comprises a plurality of pre-determined active ingredients thereby reducing the number of applications of various individual active components thus providing a cost-effective and labor-saving solution.
  • the present invention relates to a synergistic liquid pesticidal composition comprising a dithiocarbamate fungicide, a strobilurin fungicide, a conazole fungicide, an Additive blend, and at least one suitable agricultural excipient.
  • the composition comprises a dithiocarbamate fungicide, a strobilurin fungicide, a conazole fungicide, an additive blend comprising propylene glycol wherein acrylic copolymer solution, sodium dodecyl sulfate and sodium naphthalene sulphonate condensate is in the ratio of 2:1:2 and pre-determined amounts of at least one suitable agricultural excipients.
  • the dithiocarbamate fungicide is present in an amount in the range of 32 to 80 wt% based on the total weight of the composition
  • the strobilurin fungicide is present in an amount in the range of 1 to 40 wt% based on the total weight of the composition
  • the conazole fungicide is present in an amount in the range of 1 to 40 wt% based on the total weight of the composition
  • an additive blend comprising acrylic copolymer solution, sodium dodecyl sulfate and sodium naphthalene sulphonate condensate in the ratio of 2:1:2 and pre-determined amounts of at least one suitable agricultural excipients.
  • the pesticidal composition shows synergistic effect and enhanced pesticidal activity as compared to individual pesticides.
  • the dithiocarbamate fungicide is selected from the group of amobam, asomate, azithiram, carbamorph, cufraneb, cuprobam, disulfiram, ferbam, metam, nabam, tecoram, thiram, urbacide, ziram, dazomet, etem, milneb, mancopper, mancozeb, maneb, metiram, polycarbamate, propineb and zineb.
  • Suitable amounts of the dithiocarbamate fungicide in the fungicidal composition is in between 32 wt.% to 80 wt.% based on the total weight of the composition. In one embodiment, the dithiocarbamate is present in an amount in between 32 wt.% to 70 wt.% based on the total weight of the composition.
  • the strobilurin fungicide is selected from the group of azoxystrobin, coumoxystrobin, enoxastrobin, flufenoxystrobin, picoxystrobin, pyraoxystrobin, mandestrobin, pyraclostrobin, pyrametostrobin, triclopyricarb, kresoxim-methyl, trifloxystrobin, dimoxystrobin, fenaminstrobin, metominostrobin, orysastrobin, famoxadone, fluoxastrobin, fenamidone and pyribencarb.
  • Suitable amounts of the strobilurin fungicide in the composition is in between 1 wt.% to 40 wt.% based on the total weight of the composition. In one embodiment, the strobilurin is present in an amount in between 1 wt.% to 30 wt.% based on the total weight of the composition. In another embodiment, the strobilurin is present in an amount in between 1 wt.% to 20 wt.% based on the total weight of the composition.
  • the conazole fungicide is selected from the group of azaconazole, bitertanol, bromuconazole, cyproconazole, difenoconazole, diniconazole, epoxiconazole, etaconazole, fenbuconazole, fluquinconazole, flusilazole, flutriafol, hexaconazole, imibenconazole, ipconazole, metconazole, myclobutanil, penconazole, propiconazole, simeconazole, tebuconazole, tetraconazole, triadimefon, triadimenol, triticonazole, prothioconazole and tricyclazole.
  • Suitable amounts of the conazole fungicide in the composition is in between 1 wt.% to 40 wt.% based on the total weight of the composition. In one embodiment, the conazole is present in an amount in between 1 wt.% to 30 wt.% based on the total weight of the composition. In one embodiment, the conazole is present in an amount in between 1 wt.% to 20 wt.% based on the total weight of the composition.
  • the synergistic liquid pesticidal composition is formulated as a suspension concentrate (SC), Capsule Suspension (CS), Suspoemulsion (SE), Oil Dispersion (OD), Flowable suspension (FS), oil suspension concentrate and oil suspension.
  • SC suspension concentrate
  • CS Capsule Suspension
  • SE Suspoemulsion
  • OD Oil Dispersion
  • FS Flowable suspension
  • oil suspension concentrate oil suspension concentrate and oil suspension.
  • the method of application of the composition is based on the type and the properties of the formulation
  • the composition comprises Mancozeb, Azoxystrobin or Picoxystrobin, Prothioconazole, an additive blend and at least one suitable agricultural excipient.
  • the composition comprises Mancozeb, Azoxystrobin or Picoxystrobin, Difenoconazole, an additive blend and at least one suitable agricultural excipient.
  • the composition comprises Mancozeb,
  • Azoxystrobin or Picoxystrobin Propiconazole, an additive blend and at least one suitable agricultural excipient.
  • the composition comprises Mancozeb, Azoxystrobin or Picoxystrobin, Myclobutanil, an additive blend and at least one suitable agricultural excipient.
  • the at least one agricultural excipient is selected from anti-freeze agent, antifoaming agent, thickening agent, stabilizer, and preservative.
  • the anti-freeze agent can be selected from the group comprising of ethylene glycol, propylene glycol, glycerol, diethylene glycol, triethylene glycol, polyethylene glycol.
  • the antifoaming agent can be selected from the group comprising of polydimethylsiloxane powder and polydimethylsiloxane liquid, Silicon base antifoam.
  • the thickening agent can be selected from the group comprising of Xanthan gum, carboxy methyl cellulose, Hydroxymethyl propyl cellulose.
  • the stabilizer can be selected from the group comprising of phosphoric acid monoesters, phosphoric acid diesters, phosphoric acid mono- and di-ester mixture, sodium phosphates, Hexamethylene tetramine, sodium metabisulfite, butylated hydroxytoluene, castor oil ethoxylate, ethoxylated hydrogenated castor oil, vegetable oil and epoxidized soyabean oil or combinations thereof.
  • the surfactant can be selected from the group comprising of group comprising of nonionic, anionic surfactant or combination of both.
  • the preservative can be isothiazolinone, isothiazolinone mixture, benzisothiazolinone or combination thereof.
  • the water is used as a diluent to dilute the active ingredient to a desired concentration.
  • the water used is purified water and selected from the group consisting of deionized water and distilled water.
  • the composition comprises 32 to 80 wt% of a dithiocarbamate based on the total weight of the composition; 1 to 40 wt% of a strobilurin fungicide based on the total weight of the composition; 1 to 40 wt% of a conazole fungicide based on the total weight of the composition; Adjuvant blend comprising Acrylic Copolymer solution, sodium dodecyl sulfate and sodium naphthalene sulphonate condensate in the ratio is 2:1:2 and pre-determined amount of at least one agricultural excipient.
  • the at least one agricultural excipient comprise anti-freeze agent in an amount in the range of 0.1 wt% to 10 wt % based on the total weight of the composition, anti-foaming agent in an amount in the range of 0.01 wt% to 3 wt% based on the total weight of the composition, thickening agent in an amount in the range of 0.01 wt % to 3 wt % based on the total weight of the composition, stabilizer in an amount in the range of 0.1 wt % to 10 wt% based on the total weight of the composition, preservative in an amount in the range of 0.01 wt % to 3 wt % based on the total weight of the composition and water in an amount in the range of 10 wt% to 50 wt% based on the total weight of the composition.
  • the present invention discloses a process for preparing the synergistic liquid pesticidal composition.
  • the process involves blending of propylene glycol with polymer surfactant, sodium dodecyl sulphate and sodium naphthalene sulfonate condensate in water to obtain the additive mixture.
  • the premix slurry is then passed through a bead mill to obtain a concentrate suspension of a particle size in a predetermined range of 1 to 5 microns.
  • the concentrate suspension is then mixed with a dithiocarbamate fungicide, at least one suitable agricultural excipient and predetermined quantity of water to obtain the synergistic liquid pesticidal composition.
  • Example 1 A stable synergistic liquid pesticidal composition according to an embodiment of the present invention is exemplified:
  • the stable synergistic liquid pesticidal composition was prepared in accordance with the process of the present invention.
  • the composition details are disclosed in table 2 herein below:
  • composition as prepared was then analysed for their active content, viscosity, pH, Wet sieve test and suspensibility. The results are disclosed in Table 3 herein below:
  • the synergistic liquid pesticidal composition was prepared in accordance with the below mentioned process and the ingredient amounts. The composition details are illustrated in Table 4 herein below:
  • additive blends were prepared in accordance with the amounts as mentioned in Table 5 herein below:
  • Step 1 Preparation of additive blend: 350 gms of water was charged into 1 litre beaker. 50 gms of propylene glycol was then added in the beaker and stirred for 5 minutes. Further, under stirring conditions, the dispersing agent and wetting agents are added as mentioned in the table 5 to obtain the additive blends as mentioned in the Table 5.
  • Step 2 Preparation of strobilin, Conazole blend with additives:
  • Step 1 425 gms of the additive blend as prepared in Step 1 was taken in a beaker. To this beaker 27 gms of strobilin fungicide, 26 gm of conazole fungicide, and half quantity of antifoam emulsion was added under stirring conditions to obtain a pre-mix slurry. The pre-mix slurry was then passed through a bead mill such that the temperature of the material passing through the bead mill was maintained below 20 degree, to obtain a concentrate suspension of conazole / Strobilin fungicide. The concentrate suspension had a particle size in the range of 1 to 5 m. Then 50 gm of water was passed through the bead mill to recover the material remaining in the bead mill. Step 3: Preparation of strobilin/conazole/Dithiocarbamate blend:
  • the concentrate suspension 528.5 gm as obtained in Step 2 was mixed with 400 g of dithiocarbamate fungicide, balance quantity of anti-foam emulsion, 37 g of thickening agent, 1 g of preservative, 10 gm of stabilizer and balance quantity of water in a homogenizer for two hours to obtain the synergistic liquid pesticidal composition.
  • Additive blend 4 was used to prepare the synergistic liquid pesticidal composition of the present invention. The following are the results of the synergistic liquid pesticidal composition prepared using the additive blend 4.
  • additive 4 blend stabilized the composition at ageing at 54 °C for 14 days. Upon ageing at 54 °C for 14 days the composition was pourable from the container and also all the physico-chemical properties where intact. However, in rest of the composition prepared using other additive blends formed a hard cake upon ageing at 54 °C thereby demonstrating that the additive blend 4 at helps in stabilizing the formulation. Without additive the formulation is not stable and forms hard cake on ageing and also formulation is only stable when the additive in mixed in predetermined ratio.
  • the present invention provides a composition that serves the dual purpose of addressing the issue of stability of formulations comprising water insoluble active ingredients, combination of two or more active ingredients as well as provides enhanced synergistic pesticidal effect for managing the damage caused by pests while also meeting the pesticidal requirement as compared with the individual application.
  • the composition provides the advantages of synergistic pesticidal activity and enhanced stability.
  • Example 4 Bioefficay of Mancozeb 41.3 % + Picoxystrobin 3.3% + Prothioconazole 2.9% SC against grey mildew ( Ramularia areola) of Cotton
  • the liquid pesticidal composition of the present invention was tested for its bioefficacy against grey mildew of Cotton.
  • Table 7 hereinbelow summarizes the treatment details and the dosage.
  • Grey mildew Ramularia areola
  • PKI Percent disease index
  • the PDI values were transformed by angular transformation and analyzed statistically.
  • the disease control DC (%) was calculated by the following formula. Disease % in control - Disease % in treatment
  • the present liquid pesticidal composition was prepared without using the additive blend.
  • Table 8 summarizes the effects of ageing on the composition (composition devoid of additive blend).
  • Table 8 The compositions as prepared in accordance with Table 8 underwent ageing at 54 °C for 14 days (heat stability observation HT). Upon ageing at 54 °C for 14 days the composition was thick and hard lumps were also observed; thereby demonstrating that the additive blend helps in stabilizing the formulation.

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  • Life Sciences & Earth Sciences (AREA)
  • Agronomy & Crop Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Dentistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

La présente invention concerne une composition pesticide, plus particulièrement une composition pesticide liquide synergique comprenant deux principes actifs ou plus. La composition liquide synergique comprend un fongicide dithiocarbamate, un fongicide strobilurine, un fongicide conazole, un mélange d'additifs et des quantités prédéterminées d'au moins un excipient agricole approprié. La présente invention concerne également un procédé de préparation d'une composition pesticide synergique.
PCT/IN2021/050326 2020-04-01 2021-03-31 Composition pesticide synergique WO2021199079A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
BR112022013453A BR112022013453A2 (pt) 2020-04-01 2021-03-31 Composição pesticida sinérgica

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN202021014642 2020-04-01
IN202021014642 2020-04-01

Publications (1)

Publication Number Publication Date
WO2021199079A1 true WO2021199079A1 (fr) 2021-10-07

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ID=77927684

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2021/050326 WO2021199079A1 (fr) 2020-04-01 2021-03-31 Composition pesticide synergique

Country Status (2)

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BR (1) BR112022013453A2 (fr)
WO (1) WO2021199079A1 (fr)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017203527A1 (fr) * 2016-05-24 2017-11-30 Adama Makhteshim Ltd. Formulation fongicide de liquide d'huile

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017203527A1 (fr) * 2016-05-24 2017-11-30 Adama Makhteshim Ltd. Formulation fongicide de liquide d'huile

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BR112022013453A2 (pt) 2022-10-25

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