WO2021195959A1 - 一种重建步态运动功能的单端电极电子系统 - Google Patents
一种重建步态运动功能的单端电极电子系统 Download PDFInfo
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- WO2021195959A1 WO2021195959A1 PCT/CN2020/082422 CN2020082422W WO2021195959A1 WO 2021195959 A1 WO2021195959 A1 WO 2021195959A1 CN 2020082422 W CN2020082422 W CN 2020082422W WO 2021195959 A1 WO2021195959 A1 WO 2021195959A1
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- pulse signal
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
- A61N1/3606—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for a particular treatment
- A61N1/36062—Spinal stimulation
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
- A61N1/0551—Spinal or peripheral nerve electrodes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
- A61N1/3606—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for a particular treatment
- A61N1/36067—Movement disorders, e.g. tremor or Parkinson disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
- A61N1/36125—Details of circuitry or electric components
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
- A61N1/36128—Control systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
- A61N1/36128—Control systems
- A61N1/36132—Control systems using patient feedback
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
- A61N1/36128—Control systems
- A61N1/36135—Control systems using physiological parameters
- A61N1/36139—Control systems using physiological parameters with automatic adjustment
Definitions
- the invention relates to an intelligent control electronic system in the field of rehabilitation engineering and a control method thereof, in particular to a spinal cord electrical excitation device for reconstructing the gait movement function of the lower limbs.
- Functional electrical stimulation is to stimulate muscles or nerves with a certain sequence of pulse currents to restore the lost or damaged limb motor function and realize the rehabilitation of paralyzed patients.
- the purpose of the present invention is to provide a single-ended electrode electronic system for reconstructing the gait movement function, so as to solve the above-mentioned problems in the background art.
- a single-ended electrode electronic system for reconstructing gait movement function which is characterized by comprising:
- Communication system used to collect command information, generate control commands based on the command information and send them to the pulse signal generation system;
- Pulse signal generation system receives the control instruction sent by the instruction acquisition system, generates a pulse signal according to the control instruction and sends it to the biostimulation electrode.
- the pulse signal includes alternating positive voltage pulse signal trains and negative voltage pulse signal trains.
- the pulse width of the pulse signal is 200us
- the interval of the pulse signal is 30ms
- the number of pulse signals is 25-35
- the time interval between the beginnings is one-half of the gait cycle
- a pair of biostimulation electrodes fixed by an electrode fixing device, the biostimulation electrodes are fixed on the surface of the spinal cord to induce gait movement at key points, and electrical excitation is applied to the key points to achieve gait reconstruction.
- the surface of the spinal cord induces gait.
- the key point of state movement is located on the dorsal surface of the spinal cord L2 segment. Applying electrical excitation pulses to it can produce one of the left and right lower limbs stepping forward and the other stepping back. Changing the polarity of the electrical excitation pulse can make The movements of the left and right lower limbs are exchanged for the reversal points.
- the single-ended electrode electronic system for reconstructing the gait movement function of the present invention can be applied to animal experiments or rehabilitation training.
- the electronic system of the present invention generates a pulse signal, and uses the biomedical engineering method of functional electrical stimulation to activate the intrinsic interneuron network in the spinal nerve that produces the rhythmic movement of the lower limbs to generate the key points of coordinated action, in a way that is closer to the physiological condition.
- the single pair of electrodes can effectively reconstruct the gait movement function of the lower limbs.
- the present invention stimulates the neuron network in the spinal cord that controls the gait movement through the single-ended electrode, regenerates the corresponding biological nerve signal, and realizes the gait movement function of the damaged spinal cord nerve using the microelectronic method.
- the device of the present invention realizes the recovery of neurological function assisted by the microelectronic system, that is, realizes the reconstruction of gait motor function after spinal cord injury.
- Fig. 1 is a block diagram of a single-ended electrode electronic system for reconstructing the gait movement function of the present invention.
- Figure 2 is a schematic diagram of a rat experiment performed by the system of the present invention.
- Fig. 1 is a block diagram of a single-ended electrode electronic system for reconstructing gait movement function according to an embodiment of the present invention.
- the system includes: a command acquisition system, a pulse signal generation system, a biostimulation electrode and a corresponding reference electrode.
- the command collection system is used to collect command information, generate control commands according to the command information, and send them to the pulse signal generation system.
- the command acquisition system includes: brain wave signal acquisition module, voice recognition module, upper computer signal receiving module and button module.
- the brain wave signal acquisition module is used to collect brain wave signals and convert them into control instructions.
- the voice recognition module is used to recognize voice signals and convert them into control instructions.
- the upper computer signal receiving module is used to receive the control signal sent by the upper computer and convert it into control instructions.
- the button module is used to output control commands through button operation.
- the control instructions include: "start", "cadence" and "stop".
- the pulse signal generation system When the control command is "start”, the pulse signal generation system sends a pulse signal to the biostimulation electrode, and sets the time interval between the starting moments of adjacent pulse signal trains according to the “step frequency”; when the control command is “stop” “, the pulse signal generation system stops sending pulse signals to the biostimulation electrode.
- the "step frequency” is classified into multiple speed levels, and each speed level corresponds to a specified time interval.
- the pulse signal includes alternating positive voltage pulse signal trains and negative voltage pulse signal trains.
- the pulse width of the pulse signal is 200us
- the interval of the pulse signal is 30ms
- the number of pulse signals is 25-35
- the interval is one-half of the gait cycle.
- the gait cycle can be set according to the "step frequency" in the control command; a fixed gait cycle, such as 1s, can also be used.
- the current amplitude range of the positive pulse signal is 220 to 500 ⁇ A
- the current amplitude range of the negative pulse signal is -500 to -220 ⁇ A.
- the biostimulation electrode is fixed on the surface of the spinal cord by the electrode fixing device to induce the key point of gait movement.
- the reference electrode is placed at the muscle or spinal cord within 2cm of the corresponding key point.
- the biostimulation electrode is used to apply electrical excitation to the key point to achieve Gait reconstruction.
- the key point of gait motion induced on the surface of the spinal cord is the dorsal surface of the spinal cord L2 segment (in the T12 segment of the spine). Applying electrical excitation pulses to it can produce one of the left and right lower limbs stepping forward and the other stepping backward. Change the polarity of the electrical excitation pulse to make the left and right lower extremities exchange the reversal position.
- X is the transverse diameter of the spinal lumbar enlargement, Y is the head-to-tail direction of the spine, L1 is the width of the transverse diameter of the spinal lumbar enlargement; L2 is the spine The length of the T12 segment.
- the origin of the coordinates is the intersection of the posterior median sulcus of the spinal cord and the cranial cross section of the T12 segment of the spine.
- the single-ended electrode electronic system for reconstructing the gait movement function of this embodiment is suitable for application in animal experiments or rehabilitation training.
- the electronic system of this embodiment was used to test SD rats.
- the transverse direction is the X axis
- the head and tail direction of the spinal cord is the Y axis
- the stimulation site can be recorded as (X, Y)
- the coordinates (X, Y) of the key points are processed as follows: the transverse diameter direction X is normalized by one-half of the maximum transverse diameter of the spinal cord lumbar enlargement, and the head and tail direction Y is normalized by the corresponding spine segment length One treatment.
- the biostimulation electrode of the electronic system of this embodiment is placed on the surface of the key site and fixed, the reference electrode is placed at the muscle within 2cm of the corresponding key site, and then the brain wave signal acquisition module and voice recognition of the command acquisition system are respectively used.
- the module, the upper computer signal receiving module and the button module are used to issue control instructions, realize the gait reconstruction of the rat, and verify the feasibility of the electronic system of the present invention.
- a positive pulse signal is used to excite the key point B.
- the two legs of the rat are shown in Figure 2(b). The left leg moves forward and the right leg moves backward.
- Figure 2(c) is a stick diagram of the left leg joint dynamic change
- Figure 2(d) is a stick diagram of the right leg joint dynamic change.
- Figure 2(e) the key point B is excited by the reverse pulse signal
- Figure 2(f) the left leg is pushed back, and the right leg is stepped forward.
- Figure 2(g) is a stick diagram of the dynamic changes of the left leg joint
- Figure 2(h) is the dynamic change of the right leg joint. Stick figure.
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- Animal Behavior & Ethology (AREA)
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Abstract
Description
Claims (7)
- 一种重建步态运动功能的单端电极电子系统,其特征在于包括:—指令采集系统:用于采集指令信息,根据该指令信息生成控制指令并发送给脉冲信号产生系统;—脉冲信号产生系统:接收指令采集系统发送的控制指令,根据该控制指令产生脉冲信号发送给生物刺激电极,所述脉冲信号包含交替的正电压脉冲信号串和负电压脉冲信号串,所述正电压脉冲信号串和负电压脉冲信号串中,脉冲信号的脉宽为200us,脉冲信号的间隔为30ms,脉冲信号的数量为25-35个,正电压脉冲信号串起始和负电压脉冲信号串起始之间的时间间隔为步态周期的二分之一;—一对生物刺激电极:通过电极固定装置进行固定,生物刺激电极固定于脊髓表面诱发步态运动的关键位点,对该关键位点施加电激励以实现步态重建,所述脊髓表面诱发步态运动的关键位点是指位于脊髓L2节段背侧表面,对其施加电激励脉冲即能产生左右下肢中一个向前迈另一个往后蹬的动作、改变电激励脉冲的极性可使左右下肢动作方式交换反转的位点。
- 根据权利要求1所述的一种重建步态运动功能的单端电极电子系统,其特征在于:所述生物刺激电极为钨丝单端电极或者表面电极,参考电极置于距离所述关键位点2cm以内的肌肉或脊髓处。
- 根据权利要求1所述的一种重建步态运动功能的单端电极电子系统,其特征在于,所述指令采集系统包括:—脑电波信号采集模块,用于采集脑电波信号,将其识别结果转换成所述的控制指令;—语音识别模块,用于识别语音信号,将其识别结果转换成所述的控制指令;—上位机信号接收模块,用于接收上位机发送的控制信号,将其转化为所述的控制指令;—按键模块,用于通过按键操作,输出所述的控制指令。
- 根据权利要求3所述的一种重建步态运动功能的单端电极电子系统,其特征在于:控制指令包含:“开始”,“步频”和“停止”,当控制指令为“开始”时,脉冲信号产生系统向生物刺激电极发送脉冲信号,并根据“步频”设定相邻脉冲信号串的起始时刻之间的时间间隔;当控制指令为“停止”时,脉冲信号产生系统停止向生物刺激电极发送脉冲信号。
- 根据权利要求1所述的一种重建步态运动功能的单端电极电子系统,其特征在于:关键位点左右各一个,右侧关键位点的坐标范围为X=(0.377±0.196)*L1/2;Y=(0.780±0.143)*L2,左侧关键位点坐标范围为X=(-0.385±0.182)*L1/2;Y=(-0.779±0.147)*L2;X为脊髓腰膨大横径方向,Y为脊柱的头尾方向,L1是脊髓腰膨大横径的宽度;L2是脊椎T12节段的长度,坐标原点为脊髓后正中沟与脊椎T12节段头侧横截面的交点。
- 根据权利要求1所述的一种重建步态运动功能的单端电极电子系统,其特征在于:正脉冲信号的电流幅值范围为220~500μA,负脉冲信号的电流幅值范围为-500~-220μA。
- 权利要求1所述重建步态运动功能的单端电极电子系统,其特征在于:应用于动物实验或康复训练。
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AU2020203039A AU2020203039B2 (en) | 2020-03-31 | Single-ended electrode electronic system for reconstructing gait motor function | |
PCT/CN2020/082422 WO2021195959A1 (zh) | 2020-03-31 | 2020-03-31 | 一种重建步态运动功能的单端电极电子系统 |
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