WO2021170019A1 - 一种母婴菌群传递监测系统及方法 - Google Patents

一种母婴菌群传递监测系统及方法 Download PDF

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WO2021170019A1
WO2021170019A1 PCT/CN2021/077780 CN2021077780W WO2021170019A1 WO 2021170019 A1 WO2021170019 A1 WO 2021170019A1 CN 2021077780 W CN2021077780 W CN 2021077780W WO 2021170019 A1 WO2021170019 A1 WO 2021170019A1
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flora
maternal
evaluation
microflora
mother
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French (fr)
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陈择宁
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陈择宁
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    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
    • A61B10/0045—Devices for taking samples of body liquids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B50/00—Containers, covers, furniture or holders specially adapted for surgical or diagnostic appliances or instruments, e.g. sterile covers
    • A61B50/30—Containers specially adapted for packaging, protecting, dispensing, collecting or disposing of surgical or diagnostic appliances or instruments
    • A61B50/31—Carrying cases or bags, e.g. doctors' bags
    • A61B50/312—Doctors' or nurses' bags
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M35/00—Devices for applying media, e.g. remedies, on the human body
    • A61M35/003—Portable hand-held applicators having means for dispensing or spreading integral media
    • A61M35/006—Portable hand-held applicators having means for dispensing or spreading integral media using sponges, foams, absorbent pads or swabs as spreading means
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/02—Form or structure of the vessel
    • C12M23/10—Petri dish
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12M33/00—Means for introduction, transport, positioning, extraction, harvesting, peeling or sampling of biological material in or from the apparatus
    • C12M33/04—Means for introduction, transport, positioning, extraction, harvesting, peeling or sampling of biological material in or from the apparatus by injection or suction, e.g. using pipettes, syringes, needles
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6888—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
    • C12Q1/689—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
    • A61B10/0045—Devices for taking samples of body liquids
    • A61B2010/0074—Vaginal or cervical secretions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B50/00—Containers, covers, furniture or holders specially adapted for surgical or diagnostic appliances or instruments, e.g. sterile covers
    • A61B50/30—Containers specially adapted for packaging, protecting, dispensing, collecting or disposing of surgical or diagnostic appliances or instruments
    • A61B2050/314—Flexible bags or pouches
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Definitions

  • the invention belongs to the technical field of human microbiome, and relates to a system and method for monitoring the transmission of the mother-infant flora.
  • the present invention provides a system and method for monitoring the transmission of the mother-infant flora, which standardizes the transmission of the mother-infant flora, and can effectively monitor the maternal flora and the intestinal flora of newborns. And management, providing important data support for individual nutrition advice and health management.
  • a mother-infant flora transmission monitoring system including a maternal flora monitoring and evaluation sub-system, a neonatal flora monitoring and evaluation sub-system, and a flora database.
  • the colony monitoring and evaluation sub-systems all include a flora collection module and a flora analysis module; the flora database is preset with flora types classified according to the health level of the mother and infant flora transmission, and the flora types can be based on the continuous development
  • the maternal and infant microbiology and immunology research during pregnancy and pregnancy and neonatal period will be updated in a timely and iterative manner.
  • the types of flora include, but are not limited to: healthy bacteria groups, missing bacteria groups and pathogenic bacteria groups;
  • the healthy bacteria group includes at least Bacteroides, Bifidobacterium, and Escherichia; the Bifidobacterium includes at least Bifidobacterium longum and Bifidobacterium breve, and the Escherichia at least includes Escherichia coli; if it does not contain Bacteroides, it is the deletion bacteria group; if Enterobacter cloacae or Klebsiella pneumonia exists, it is the pathogenic bacteria group;
  • the pregnant and parturient flora monitoring and evaluation sub-system evaluates the pregnant and parturient flora based on the pregnant and parturient flora collected by its flora collection module and through its flora analysis module and the type of flora in the flora database.
  • the evaluation result is a healthy bacterial group, it is recommended to continue to maintain and can be used to supplement the neonatal flora; when the evaluation result is a missing bacterial group, Give suggestions on the need to supplement the colonization of bacteria; when the assessment result is the pathogenic bacteria group, give suggestions on the need to adjust and actively treat;
  • the neonatal flora monitoring and evaluation system is based on the neonatal initial flora collected by its flora collection module, and evaluates the neonate’s initial flora through its flora analysis module and the type of flora in the flora database.
  • the evaluation result of the flora type of the flora and relevant suggestions are given, and finally the evaluation result and the relevant suggestions are displayed on the display module; when the evaluation result is a healthy flora, a suggestion that no supplementation of the flora is required is given; When the evaluation result is a missing bacterial group, a suggestion is given that the flora needs to be supplemented; when the evaluation result is a pathogenic bacterial group, a suggestion that the flora needs to be supplemented and actively treated is given.
  • the mother-infant microflora transmission monitoring system further includes a maternal breast milk microflora monitoring and evaluation sub-system
  • the maternal breast milk microflora monitoring and evaluation sub-system includes a breast milk microflora collection module and a breast milk microflora analysis module.
  • the maternal breast milk microflora monitoring and evaluation system is based on the maternal breast milk microflora collected by the breast milk microflora collection module, and the bacteria of the maternal breast milk microflora are evaluated by the breast milk microflora analysis module and the microflora type in the microflora database.
  • the group type evaluation result and relevant suggestions are given; when the evaluation result is a healthy bacterial group, a suggestion to continue to be maintained; when the evaluation result is a missing bacterial group, a suggestion that needs to be supplemented and adjusted is given; When the assessment result is the pathogenic bacteria group, recommendations for adjustment and active treatment are given.
  • the initial neonatal flora includes meconium flora during the neonatal period.
  • the maternal breast milk microflora includes the microflora obtained after high-throughput sequencing of the microflora of maternal colostrum.
  • the maternal flora includes the flora obtained after high-throughput sequencing of the flora of their vaginal secretions or the flora obtained after high-throughput sequencing of the flora of the feces of pregnant women.
  • the mother-infant flora transmission monitoring system further includes a display module and a storage module, the display module is used to display the evaluation result and the related suggestions, and the storage module is used to set according to each user Store the maternal microflora, maternal breast milk microflora and neonatal microflora.
  • a flora collection auxiliary device for assisting the mother-infant flora transfer monitoring system to collect the flora including sterile cleaning wipes for cleaning around the vagina, and a non-bacterial device for draining the vaginal secretions of the parturient Bacterial vagina expansion clip, medical sterile cotton dipped in vaginal secretions, medical gloves, petri dishes for culturing bacteria, soft cotton swabs that can be inserted into the mouth of newborns, and those that can be applied to newborns and maternal breasts Soft cotton gauze.
  • the flora collection auxiliary device further includes a heater for keeping the sterile cleansing wipes, sterile vaginal expansion clips, and sterile medical cotton at body temperature; and for sealing and placing the sterile cleaning Wet wipes, sterile vaginal expansion clips, sterile medical cotton, petri dishes, soft cotton swabs, soft cotton gauze, and heaters.
  • a heater for keeping the sterile cleansing wipes, sterile vaginal expansion clips, and sterile medical cotton at body temperature; and for sealing and placing the sterile cleaning Wet wipes, sterile vaginal expansion clips, sterile medical cotton, petri dishes, soft cotton swabs, soft cotton gauze, and heaters.
  • a method for monitoring the transmission of mother-to-child flora which is characterized in that it comprises the following steps:
  • Step 1 Use the microflora collection auxiliary device to collect the maternal microflora, that is, collect the maternal microflora, and use the maternal-infant microflora transmission monitoring system to evaluate the collected maternal intestinal flora ,
  • the evaluation result is a healthy bacterial group
  • the evaluation result is a lack of bacterial group
  • when the evaluation result is the pathogenic bacteria group give suggestions that need to be adjusted and actively treated, and continue to carry out the flora Collection and evaluation to monitor the status of maternal flora;
  • Step 2 After the pregnant women who have passed the bacterial flora test enter the delivery room, use the flora collection auxiliary device to collect the vaginal secretions of the lying-in women before the cesarean section operation, and apply a part of the collected pregnant and lying-in women's flora directly to the birth doctor or
  • the surgical gloves of the midwife nurse when the fetus is taken out, the midwife doctor or the midwife nurse wears surgical gloves smeared with the maternal flora, so that the newborns who have just left the mother’s uterus will immediately come into contact with the maternal flora, especially pay attention to let the newborn directly Part of the maternal flora on the surgical gloves is sucked into their intestines through the mouth; the other part of the collected maternal flora is placed in a petri dish, so that sterile cotton and medical gloves can fully obtain the flora.
  • the nurse can operate with medical gloves.
  • the newborn is weighed and wrapped, apply the sterile cotton that has obtained the maternal flora to the skin and apply the mother at the same time Nipples to minimize the loss of neonatal non-birth canal flora during delivery.
  • Step 3 Use the flora collection auxiliary device to collect neonatal meconium, perform high-throughput fecal bacteria sequencing, that is, collect neonatal meconium flora, and use the mother-infant flora transfer monitoring system to monitor the collected neonates The meconium microflora is evaluated for the flora.
  • the evaluation result is a healthy microbiota
  • suggestions are given that there is no need to apply it again and continue to be maintained, and the flora collection and evaluation are continued to monitor the status of the neonatal flora
  • the evaluation result is When the bacteria group is missing, it is recommended to go through re-application or probiotics supplementation, and continue to collect and evaluate the flora after adjustment to monitor the status of the neonatal flora; when the evaluation result is a pathogenic bacteria group, Suggestions that need to be adjusted by probiotics and actively treated are given, and the flora collection and evaluation are continued to monitor the status of the neonatal flora.
  • the maternal flora is sampled and fermented in a petri dish, so that it can be adequately used when smearing with the neonatal meconium flora, and can also be used for related bacteria. Group detection.
  • the system and method for monitoring the transmission of the mother-infant flora of the present invention can carry out standardized management of the transmission of the mother-infant flora, and can effectively track and manage the intestinal flora of pregnant women and newborns. Individual nutrition advice and health management provide important data support.
  • the system and method for monitoring the transmission of the mother-infant flora of the present invention can monitor and manage the intestinal flora of pregnant and lying-in women, so as to facilitate the treatment of unhealthy flora through dietary advice or flora adjustment or even treatment.
  • the structure and harmful pathogenic diseases are improved and adjusted to make the bacteria obtained from the mother's body healthier when the newborn is born, and can make up for the lack of maternal bacterial transmission in the newborn by caesarean section, thereby reducing the incidence of neonatal allergies and asthma. Risk plays a positive role.
  • the microflora collection auxiliary device of the present invention can safely take out the secretions of the parturient’s obstetric canal before delivery, and apply it in time after delivery, so as to facilitate contact with the flora at the newborn’s birth and carry out the first intestinal tract in life.
  • the key moment for the determination of the flora is timely colonization from the maternal flora, which is designed as an operation package to facilitate the uniform application of the mother's birth canal flora to the mouth and skin of the newborns delivered by cesarean section, reducing the loss of flora transmission.
  • Figure 1 is a block diagram of a system and method for monitoring the transmission of the mother-infant flora of the present invention
  • Fig. 2 is a flow chart of a system and method for monitoring the transmission of the mother-infant flora of the present invention.
  • a monitoring system for the transmission of the mother-infant flora including the monitoring and evaluation sub-system for the maternal flora, the monitoring and evaluation sub-system for the neonatal flora, and the flora database,
  • the flora database is preset with flora types classified according to the health level of the mother-infant flora transmission.
  • the flora type is constantly updated according to the evolving maternal and infant microbiology and immunology research during pregnancy and neonatal period.
  • the present invention takes microbiology and immunology as the main dimensions, and evaluates and categorizes the flora types according to relevant latest research.
  • the types of flora include but are not limited to the following groups: healthy bacteria group, missing bacteria group, pathogenic bacteria Group
  • the healthy bacteria group includes at least Bacteroides, Bifidobacterium, and Escherichia; the Bifidobacterium includes at least Bifidobacterium longum and Bifidobacterium breve, and the Escherichia at least includes Escherichia coli;
  • Enterobacter cloacae or Klebsiella pneumoniae it is the group of pathogenic bacteria
  • the pregnant and parturient flora monitoring and evaluation sub-system evaluates the pregnant and parturient flora based on the pregnant and parturient flora collected by its flora collection module and through its flora analysis module and the type of flora in the flora database.
  • the evaluation result is a healthy bacterial group, it is recommended to continue to maintain and can be used to supplement the neonatal flora; when the evaluation result is a missing bacterial group, Give suggestions for supplementation of bacterial colonization; when the assessment results are pathogenic bacteria groups, give suggestions for active treatment and adjustment;
  • the neonatal flora monitoring and evaluation system is based on the neonatal initial flora collected by its flora collection module, and evaluates the neonate’s initial flora through its flora analysis module and the type of flora in the flora database.
  • the evaluation result of the flora type of the flora and relevant suggestions are given, and finally the evaluation result and the relevant suggestions are displayed on the display module; when the evaluation result is a healthy flora, a suggestion that no supplementation of the flora is required is given; When the evaluation result is a missing bacterial group, a suggestion is given that the flora needs to be supplemented; when the evaluation result is a pathogenic bacterial group, a suggestion that the flora needs to be supplemented and actively treated is given.
  • the mother-infant flora transmission monitoring system also includes a maternal breast milk flora monitoring and evaluation sub-system
  • the maternal breast milk flora monitoring and evaluation sub-system includes a breast milk flora collection module and Breast milk microflora analysis module
  • the maternal breast milk microflora monitoring and evaluation system performs microflora evaluation based on the maternal breast milk microflora collected by the breast milk microflora collection module through the breast milk microflora analysis module and the microflora types in the microflora database
  • the initial neonatal flora includes meconium flora during the neon
  • the pregnant and lying-in women's flora includes the flora obtained by performing high-throughput sequencing of fecal bacteria on their vaginal secretions.
  • the maternal breast milk microflora includes the microflora obtained after high-throughput sequencing of the microflora of maternal colostrum.
  • the mother-infant flora transmission monitoring system further includes a display module, and the display module is used to display the evaluation result and the related suggestion.
  • a flora collection auxiliary device for assisting the mother-infant flora transfer monitoring system to collect the flora which is characterized in that it comprises a sterile cleaning wipe for cleaning around the vagina, and is used for vaginal secretion of the parturient.
  • the sterile medical gloves are convenient for surgeons or nurses to wear to obtain maternal flora in a sterile environment.
  • the flora collection auxiliary device also includes a heater for keeping the sterile cleaning wipes, sterile vaginal dilation clips, medical sterile cotton, etc. at body temperature; and for sealing and placing the sterile cleaning wipes , Sterile vaginal dilation clip, medical sterile cotton, petri dish, soft cotton swab, soft cotton gauze and auxiliary package for production of heater.
  • the bacterial colony collection auxiliary device also includes an auxiliary bag for delivery, which is used to place the sterile clean wet wipes, sterile vaginal expansion clips, medical sterile cotton, petri dishes, soft cotton swabs, soft cotton gauze, and heaters.
  • a method for monitoring the transmission of mother-to-child flora which is characterized in that it comprises the following steps:
  • Step 1 Use the microflora collection auxiliary device to collect the vaginal flora of pregnant women, that is, collect the maternal flora, and use the maternal-infant flora transmission monitoring system to perform flora on the collected intestinal flora of pregnant women Evaluation, when the evaluation result is a healthy bacterial group, give suggestions for continued maintenance, and continue to collect and evaluate the bacterial flora to monitor the status of the maternal flora; when the evaluation result is a missing bacterial group, give the need to go through Suggestions for modification and adjustment, and continuous collection and evaluation of the flora after modification and adjustment to monitor the status of the maternal flora; when the evaluation result is a pathogenic bacteria group, recommendations for modification, adjustment and active treatment are given, and Continue to collect and evaluate the flora to monitor the status of the maternal flora;
  • Step 2 After the pregnant and parturient women who have passed the bacterial flora test enter the delivery room, use the flora collection auxiliary device to collect the vaginal flora of the parturient before the cesarean section operation, and apply part of the collected pregnant and parturient flora directly to the midwife doctor or
  • the surgical gloves of the midwife nurse when the fetus is taken out, the midwife doctor or the midwife nurse wears surgical gloves smeared with the maternal flora, so that the newborns who have just left the mother’s uterus will immediately come into contact with the maternal flora, especially pay attention to let the newborn directly Part of the maternal flora on the surgical gloves is sucked into their intestines through the mouth; the other part of the collected maternal flora is placed in a petri dish, so that sterile cotton and medical gloves can fully obtain the flora.
  • the nurse can operate with medical gloves.
  • the newborn is weighed and wrapped, apply the sterile cotton that has obtained the maternal flora to the skin and apply the mother at the same time Nipples to minimize the loss of neonatal non-birth canal flora during delivery.
  • Step 3 Use the flora collection auxiliary device to collect neonatal meconium, perform high-throughput fecal bacteria sequencing, that is, collect neonatal meconium flora, and use the mother-infant flora transfer monitoring system to monitor the collected neonates The meconium microflora is evaluated for the flora.
  • the evaluation result is a healthy microbiota
  • suggestions are given that there is no need to apply it again and continue to be maintained, and the flora collection and evaluation are continued to monitor the status of the neonatal flora
  • the evaluation result is When the bacteria group is missing, it is recommended to go through re-application or probiotics supplementation, and continue to collect and evaluate the flora after adjustment to monitor the status of the neonatal flora; when the evaluation result is a pathogenic bacteria group, Suggestions that need to be adjusted by probiotics and actively treated are given, and the flora collection and evaluation are continued to monitor the status of the neonatal flora.
  • the maternal flora is sampled and fermented in a petri dish, so that it can be used when smearing with newborns, and it can also be applied to bacteria.
  • Group detection the maternal flora is sampled and fermented in a petri dish, so that it can be used when smearing with newborns, and it can also be applied to bacteria.

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Abstract

一种母婴菌群传递监测系统及方法，通过孕产妇菌群监测及评估分系统和新生儿菌群监测及评估分系统，将孕产妇及新生儿的肠道菌分为健康菌群组、缺失菌群组、致病菌群组，以对母婴菌群的传递进行标准化管理，并通过菌群评估对孕产妇及新生儿的肠道菌群进行有效的跟踪管理，为个体营养建议和健康管理提供重要数据支持。

Description

一种母婴菌群传递监测系统及方法 技术领域
本发明属于人类微生物组技术领域，涉及一种母婴菌群传递监测系统及方法。
背景技术
遗传及生物学、免疫学各项研究显示，剖宫产的新生儿因其未经母体产道，母体的菌群未能正常传递给剖宫产新生儿，从而使得剖宫产的新生儿在生长发育过程中发生肥胖、过敏及哮喘等各类疾病的风险提高。在整个孕产期间，目前医院没有对孕产妇菌群进行检测和分辨，特别是对于罹患慢性疾病如妊娠期糖尿病的孕产妇，若菌群病变，反而可能给新生儿带来不好的菌群，影响其健康发育，因此孕产妇分娩前进行相关菌群监测及干预治疗，能使分娩时传递给新生儿的菌群得以保持健康。
目前对于剖宫产产妇的母婴菌群传递，市场上存在一些用于传递母婴菌群的抹布等，直接将产妇阴道分泌物通过该抹布取出给新生儿擦拭，操作过程缺乏规范，可能会对婴儿或产妇带来不利影响。
发明内容
为解决上述问题，本发明提供一种母婴菌群传递监测系统及方法，对母婴菌群的传递进行标准化管理，并可对孕产妇菌群及新生儿的肠道菌群进行有效的监控和管理，为个体营养建议和健康管理提供重要数据支持。
本发明通过以下技术方案实现：
一种母婴菌群传递监测系统，包括孕产妇菌群监测及评估分系统、新生儿菌群监测及评估分系统和菌群数据库，所述孕产妇菌群监测及评估分系统、新生儿菌群监测及评估分系统均包括菌群采集模块和菌群分析模块；所述菌群数据库预置有按照母婴菌群传递健康等级分类的菌群类型，所述菌群类型可根据不断发展中的孕产期及新生儿期母婴微生物学和免疫学研究，进行及时迭代更新，所述菌群类型包括但不限于：健康菌群组、缺失菌群组和致病菌群组；
所述健康菌群组至少包括拟杆菌属、双歧杆菌属和埃希氏菌属；所述双歧杆菌属至少包括长双歧杆菌和短双歧杆菌，所述埃希氏菌属至少包括大肠肝菌；若不含有拟杆菌属，则为所述缺失菌群组；若存在阴沟肠杆菌或肺炎克雷伯氏菌，则为所述致病菌群组；
所述孕产妇菌群监测及评估分系统根据其菌群采集模块采集到的孕产妇菌群，通过其菌群分析模块与菌群数据库中的菌群类型进行菌群评估得出孕产妇菌群的菌群类型评估结果并给出相关建议，所述评估结果为健康菌群组时，给出继续保持且可以用于新生儿菌群补充的建议；所述评估结果为缺失菌群组时，给出需进行菌群定植补充的建议；所述评估结果为致病菌群组时，给出需调节并积极治疗的建议；
所述新生儿菌群监测及评估分系统根据其菌群采集模块采集到的新生儿初始菌群，通过其菌群分析模块与菌群数据库中的菌群类型进行菌群评估得出新生儿初始菌群的菌群类型评估结果并给出相关建议，最后将所述评估结果和所述相关建议显示于显示模块；所述评估结果为健康菌群组时，给出无需菌群补充的建议；所述评估结果为缺失菌群组时，给出需菌群补充的建议；所述评估结果为致病菌群组时，给出需菌群补充并积极治疗的建议。
作为优选，所述母婴菌群传递监测系统还包括产妇母乳菌群监测及评估分系统，所述产妇母乳菌群监测及评估分系统包括母乳菌群采集模块和母乳菌群分析模块，所述产妇母乳菌群监测及评估分系统根据母乳菌群采集模块采集到的产妇母乳菌群，通过母乳菌群分析模块与菌群数据库中的菌群类型进行菌群评估得出产妇母乳菌群的菌群类型评估结果并给出相关建议；所述评估结果为健康菌群组时，给出继续保持的建议；所述评估结果为缺失菌群组时，给出需补充及调节的建议；所述评估结果为致病菌群组时，给出需调节并积极治疗的建议。
作为优选，所述新生儿初始菌群包括新生儿期间胎便菌群。
作为优选，所述产妇母乳菌群包括对产妇初乳进行菌群高通量测序后得到的菌群。
作为优选，所述孕产妇菌群包括对其阴道分泌物进行菌群高通量测序后得到的菌群或对孕产妇粪便进行菌群高通量测序后得到的菌群。
作为优选，所述母婴菌群传递监测系统还包括显示模块和存储模块，所述显示模块用于显示所述评估结果和所述相关建议，所述存储模块用于根据每个用户的设定存储所述孕产妇菌群、产妇母乳菌群和新生儿菌群。
一种用于辅助所述母婴菌群传递监测系统进行菌群采集的菌群采集辅助装置，包括用于对阴道周围进行清理的无菌清洁湿巾、用于将产妇阴道分泌物引流的无菌阴道扩张夹、蘸取阴道分泌物的医用无菌棉、医用手套、用于培养菌群的培养皿、可伸入新生儿口腔的柔软棉棒及可在新生儿身上和产妇乳房上涂抹的柔软棉纱布。
作为优选，所述菌群采集辅助装置还包括用于使所述无菌清洁湿巾、无菌阴道扩张夹、医用无菌棉保持在体温的加热器；和用于密封放置所述无菌清洁湿巾、无菌阴道扩张夹、医用无菌棉、培养皿、柔软棉棒、柔软棉纱布及加热器的待产辅助包。
一种母婴菌群传递监测方法，其特征在于，包括以下步骤：
步骤一、用所述菌群采集辅助装置采集孕产妇菌群，即进行孕产妇菌群采集，并使用所述母婴菌群传递监测系统对采集到的孕产妇肠道菌群进行菌群评估，当评估结果为健康菌群组时，给出继续保持的建议，并持续进行菌群采集和评估以监测孕产妇菌群状态；所述评估结果为缺失菌群组时，给出需进行调节的建议，并在调节后持续进行菌群采集和评估以监测孕产妇菌群状态；所述评估结果为致病菌群组时，给出需经过调节并积极治疗的建议，且持续进行菌群采集和评估以监测孕产妇菌群状态；
步骤二，在菌群检测合格的孕产妇进入产房后，使用所述菌群采集辅助装置在剖宫产手术进行前采集产妇阴道分泌物，将采集到的孕产妇菌群一部分直接涂抹接生医生或接生护士的手术手套，在取出胎儿时接生医生或接生护士穿戴涂抹有孕产妇菌群的手术手套，使刚离开母体的刨宫产新生儿立即接触到母体菌群，尤其需要注意让新生儿直接将手术手套上的部分孕产妇菌群通过口腔吸入腹部进入其肠道；采集到的孕产妇菌群的另外一部分放入培养皿中，让无菌棉花和医用手套充分获得菌群，在新生儿成功分娩取出后交给护士处置胎盘和脐带时，该护士可用医用手套来操作，而在新生儿称完体重进行包裹时，用已经获得母体菌群的无菌棉进行皮肤涂抹，并同时涂抹妈妈的乳头，以最大化减少分娩时新生儿未经产道的菌群缺失。
步骤三，用所述菌群采集辅助装置采集新生儿胎便，进行粪菌高通量测序，即进行新生儿胎便菌群采集，并使用所述母婴菌群传递监测系统对采集到的新生儿胎便菌群进行菌群评估，当评估结果为健康菌群组时，给出无需再次涂抹并继续保持的建议，并持续进行菌群采集和评估以监测新生儿菌群状态；所述评估结果为缺失菌群组时，给出需经过再次涂抹或益生菌补充定植建议，并在调节后持续进行菌群采集和评估以监测新生儿菌群状态；所述评估结果为致病菌群组时，给出需经过益生菌调节并积极治疗的建议，且持续进行菌群采集和评估以监测新生儿菌群状态。
作为优选，所述步骤二中进行产妇菌群采集时，将所述产妇菌群在培养皿中留样和发酵，以便于与新生儿胎便菌群进行涂抹时能足够使用，也可用于相关菌群检测。
本发明相对于现有技术优势在于：
1、本发明所述的一种母婴菌群传递监测系统及方法，对母婴菌群的传递进行标准化管理，并可对孕产妇及新生儿的肠道菌群进行有效的跟踪管理，为个体营养建议和健康管理提供重要数据支持。
2、本发明所述的一种母婴菌群传递监测系统及方法，对孕产妇的肠道菌群进行健康监测管理，以便于通过饮食建议或菌群调节甚至治疗等方法对不健康的菌群结构以及有害致病病 进行改善调整，使得新生儿出生时从母体获得菌群更加健康，并能够及时弥补剖腹产新生儿母体菌体传递的缺失，从而对降低了新生儿过敏及哮喘等疾病发生的风险起到积极作用。
3、本发明所述的菌群采集辅助装置，可在产前安全取出产妇产道分泌物，在产中产后及时进行涂抹，便于在新生儿出生接触菌群，进行人生第一次肠道菌群定值的关键时刻及时进行来自母体菌群定植，经过设计成操作包，便于将母亲产道菌群均匀涂抹在剖宫产新生儿口腔及皮肤，减少菌群传递的缺失。
附图说明
图1为本发明一种母婴菌群传递监测系统及方法的模块框图；
图2为本发明一种母婴菌群传递监测系统及方法的流程图。
具体实施方式
为了便于理解本发明，下面结合附图和具体实施例，对本发明进行更详细的说明。
一种母婴菌群传递监测系统，包括孕产妇菌群监测及评估分系统、、新生儿菌群监测及评估分系统和菌群数据库，
所述孕产妇菌群监测及评估分系统和新生儿菌群监测及评估分系统均包括菌群采集模块和菌群分析模块；
所述菌群数据库预置有按照母婴菌群传递健康等级分类的菌群类型。
犹如不断迭代的遗传学研究，所述菌群类型根据不断发展的孕产期及新生儿期母婴微生物学和免疫学研究进行不断的更新。本发明以微生物学和免疫学为主要维度，根据相关最新研究，将所述菌群类型进行评估分类，菌群类型包括但不仅限于以下分组：健康菌群组、缺失菌群组、致病菌群组；
所述健康菌群组至少包括拟杆菌属、双歧杆菌属和埃希氏菌属；所述双歧杆菌属至少包括长双歧杆菌和短双歧杆菌，所述埃希氏菌属至少包括大肠肝菌；
若不含有拟杆菌属，则为所述缺失菌群组；
若存在阴沟肠杆菌或肺炎克雷伯氏菌，则为所述致病菌群组；
所述孕产妇菌群监测及评估分系统根据其菌群采集模块采集到的孕产妇菌群，通过其菌群分析模块与菌群数据库中的菌群类型进行菌群评估得出孕产妇菌群的菌群类型评估结果并给出相关建议，所述评估结果为健康菌群组时，给出继续保持且可以用于新生儿菌群补充的建议；所述评估结果为缺失菌群组时，给出需进行菌群定植补充的建议；所述评估结果为致病菌群组时，给出积极治疗和调节的的建议；
所述新生儿菌群监测及评估分系统根据其菌群采集模块采集到的新生儿初始菌群，通过其菌群分析模块与菌群数据库中的菌群类型进行菌群评估得出新生儿初始菌群的菌群类型评估结果并给出相关建议，最后将所述评估结果和所述相关建议显示于显示模块；所述评估结果为健康菌群组时，给出无需菌群补充的建议；所述评估结果为缺失菌群组时，给出需菌群补充的建议；所述评估结果为致病菌群组时，给出需菌群补充并积极治疗的建议。
实施例2
本实施例与上述实施例不同的是，所述母婴菌群传递监测系统还包括产妇母乳菌群监测及评估分系统，所述产妇母乳菌群监测及评估分系统包括母乳菌群采集模块和母乳菌群分析模块，所述产妇母乳菌群监测及评估分系统根据母乳菌群采集模块采集到的产妇母乳菌群，通过母乳菌群分析模块与菌群数据库中的菌群类型进行菌群评估得出产妇母乳菌群的菌群类型评估结果并给出相关建议；所述评估结果为健康菌群组时，给出继续保持的建议；所述评估结果为缺失菌群组时，给出需补充及调节的建议；所述评估结果为致病菌群组时，给出需调节并积极治疗的建议。作为优选，所述新生儿初始菌群包括新生儿期间胎便菌群。
作为优选，所述孕产妇菌群包括对其阴道分泌物，进行粪菌高通量测序后得到的菌群。
作为优选，所述产妇母乳菌群包括对产妇初乳进行菌群高通量测序后得到的菌群。
作为优选，所述母婴菌群传递监测系统还包括还包括显示模块，所述显示模块用于显示所述评估结果和所述相关建议。
实施例3
一种用于辅助所述母婴菌群传递监测系统进行菌群采集的菌群采集辅助装置，其特征在于，包括用于对阴道周围进行清理的无菌清洁湿巾、用于将产妇阴道分泌物引流的无菌阴道扩张夹、蘸取阴道分泌物的医用无菌棉、无菌医用手套、用于培养菌群的培养皿、可伸入新生儿口腔的柔软棉棒及可在新生儿身上涂抹的柔软棉纱布。所述无菌医用手套方便手术医生或护士穿戴，以在无菌环境下获取孕产妇菌群。
所述菌群采集辅助装置还包括用于使所述无菌清洁湿巾、无菌阴道扩张夹、医用无菌棉等保持在体温的加热器；和用于密封放置所述无菌清洁湿巾、无菌阴道扩张夹、医用无菌棉、培养皿、柔软棉棒、柔软棉纱布及加热器的待产辅助包。
所述菌群采集辅助装置还包括待产辅助包，用于放置所述无菌清洁湿巾、无菌阴道扩张夹、医用无菌棉、培养皿、柔软棉棒、柔软棉纱布及加热器。
实施例4
一种母婴菌群传递监测方法，其特征在于，包括以下步骤：
步骤一、用所述菌群采集辅助装置采集孕产妇阴道菌群，即进行孕产妇菌群采集，并使 用所述母婴菌群传递监测系统对采集到的孕产妇肠道菌群进行菌群评估，当评估结果为健康菌群组时，给出继续保持的建议，并持续进行菌群采集和评估以监测孕产妇菌群状态；所述评估结果为缺失菌群组时，给出需经过修饰调节的建议，并在修饰调节后持续进行菌群采集和评估以监测孕产妇菌群状态；所述评估结果为致病菌群组时，给出需经过修饰调节并积极治疗的建议，且持续进行菌群采集和评估以监测孕产妇菌群状态；
步骤二，在菌群检测合格的孕产妇进入产房后，使用所述菌群采集辅助装置在剖宫产手术进行前采集产妇阴道菌群，将采集到的孕产妇菌群一部分直接涂抹接生医生或接生护士的手术手套，在取出胎儿时接生医生或接生护士穿戴涂抹有孕产妇菌群的手术手套，使刚离开母体的刨宫产新生儿立即接触到母体菌群，尤其需要注意让新生儿直接将手术手套上的部分孕产妇菌群通过口腔吸入腹部进入其肠道；采集到的孕产妇菌群的另外一部分放入培养皿中，让无菌棉花和医用手套充分获得菌群，在新生儿成功分娩取出后交给护士处置胎盘和脐带时，该护士可用医用手套来操作，而在新生儿称完体重进行包裹时，用已经获得母体菌群的无菌棉进行皮肤涂抹，并同时涂抹妈妈的乳头，以最大化减少分娩时新生儿未经产道的菌群缺失。
步骤三，用所述菌群采集辅助装置采集新生儿胎便，进行粪菌高通量测序，即进行新生儿胎便菌群采集，并使用所述母婴菌群传递监测系统对采集到的新生儿胎便菌群进行菌群评估，当评估结果为健康菌群组时，给出无需再次涂抹并继续保持的建议，并持续进行菌群采集和评估以监测新生儿菌群状态；所述评估结果为缺失菌群组时，给出需经过再次涂抹或益生菌补充定植建议，并在调节后持续进行菌群采集和评估以监测新生儿菌群状态；所述评估结果为致病菌群组时，给出需经过益生菌调节并积极治疗的建议，且持续进行菌群采集和评估以监测新生儿菌群状态。
作为优选，所述步骤二中进行孕产妇菌群采集时，将所述孕产妇菌群在培养皿中留样和发酵，以便于与新生儿进行涂抹时能保持足够使用，也可实用于菌群检测。
尽管上面已经示出和描述了本发明的实施例，可以理解的是，上述实施例是示例性的，不能理解为对本发明的限制，本领域的普通技术人员在本发明的范围内可以对上述实施例进行变化、修改、替换和变型。

Claims (10)

  1. 一种母婴菌群传递监测系统，其特征在于，包括孕产妇菌群监测及评估分系统、新生儿菌群监测及评估分系统和菌群数据库，
    所述孕产妇菌群监测及评估分系统、新生儿菌群监测及评估分系统均包括菌群采集模块和菌群分析模块；
    所述菌群数据库预置有按照母婴菌群传递健康等级分类的菌群类型，所述菌群类型可根据不断发展的孕产期及新生儿期母婴微生物学和免疫学研究进行及时迭代更新；目前孕产妇所述菌群类型包括但不限于：健康菌群组、缺失菌群组和致病菌群组；
    所述健康菌群组至少包括拟杆菌属、双歧杆菌属和埃希氏菌属；所述双歧杆菌属至少包括长双歧杆菌和短双歧杆菌，所述埃希氏菌属至少包括大肠肝菌；
    若不含有拟杆菌属，则为所述缺失菌群组；
    若存在阴沟肠杆菌或肺炎克雷伯氏菌，则为所述致病菌群组；
    所述孕产妇菌群监测及评估分系统根据其菌群采集模块采集到的孕产妇菌群，通过其菌群分析模块与菌群数据库中的菌群类型进行菌群评估得出孕产妇菌群的菌群类型评估结果并给出相关建议，所述评估结果为健康菌群组时，给出继续保持且可以用于新生儿菌群补充的建议；所述评估结果为缺失菌群组时，给出需进行菌群定植补充的建议；所述评估结果为致病菌群组时，给出积极治疗和调节的的建议；
    所述新生儿菌群监测及评估分系统根据其菌群采集模块采集到的新生儿初始菌群，通过其菌群分析模块与菌群数据库中的菌群类型进行菌群评估得出新生儿初始菌群的菌群类型评估结果并给出相关建议，最后将所述评估结果和所述相关建议显示于显示模块；所述评估结果为健康菌群组时，给出无需菌群补充的建议；所述评估结果为缺失菌群组时，给出需菌群补充的建议；所述评估结果为致病菌群组时，给出需菌群补充并积极治疗的建议。
  2. 根据权利要求1所述的母婴菌群传递监测系统，其特征在于，还包括产妇母乳菌群监测及评估分系统，所述产妇母乳菌群监测及评估分系统包括母乳菌群采集模块和母乳菌群分析模块，所述产妇母乳菌群监测及评估分系统根据母乳菌群采集模块采集到的产妇母乳菌群，通过母乳菌群分析模块与菌群数据库中的菌群类型进行菌群评估得出产妇母乳菌群的菌群类型评估结果并给出相关建议；所述评估结果为健康菌群组时，给出继续保持的建议；所述评估结果为缺失菌群组时，给出需补充及调节的建议；所述评估结果为致病菌群组时，给出需调节并积极治疗的建议。
  3. 根据权利要求1所述的母婴菌群传递监测系统，其特征在于，所述新生儿初始菌群包括新生儿期间胎便菌群。
  4. 根据权利要求2所述的母婴菌群传递监测系统，其特征在于，所述产妇母乳菌群包括对产妇初乳进行菌群高通量测序后得到的菌群。
  5. 根据权利要求1所述的母婴菌群传递监测系统，其特征在于，所述孕产妇菌群包括对其阴道分泌物进行菌群高通量测序后得到的菌群。
  6. 根据权利要求2所述的母婴菌群传递监测系统，其特征在于，还包括显示模块和存储模块，所述显示模块用于显示所述评估结果和所述相关建议，所述存储模块用于根据每个用户的设定存储所述孕产妇菌群、产妇母乳菌群和新生儿菌群。
  7. 一种用于辅助所述母婴菌群传递监测系统进行菌群采集的菌群采集辅助装置，其特征在于，包括用于对阴道周围进行清理的无菌清洁湿巾、用于将产妇阴道分泌物引流的无菌阴道扩张夹、蘸取阴道分泌物的医用无菌棉、医用手套、用于培养菌群的培养皿、可伸入新生儿口腔的柔软棉棒及可在新生儿身上和产妇乳房上涂抹的柔软棉纱布。
  8. 根据权利要求7所述的菌群采集辅助装置，其特征在于，所述菌群采集辅助装置还包括用于使所述无菌清洁湿巾、无菌阴道扩张夹、医用无菌棉保持在体温的加热器；和用于密封放置所述无菌清洁湿巾、无菌阴道扩张夹、医用无菌棉、培养皿、柔软棉棒、柔软棉纱布及加热器的待产辅助包。
  9. 一种母婴菌群传递监测方法，其特征在于，包括以下步骤：
    步骤一、用所述菌群采集辅助装置采集孕产妇菌群，即进行孕产妇菌群采集，并使用所述母婴菌群传递监测系统对采集到的孕产妇肠道菌群进行菌群评估，当评估结果为健康菌群组时，给出继续保持的建议，并持续进行菌群采集和评估以监测孕产妇菌群状态；所述评估结果为缺失菌群组时，给出需经过调节的建议，并在调节后持续进行菌群采集和评估以监测孕产妇菌群状态；所述评估结果为致病菌群组时，给出需经过调节并积极治疗的建议，且持续进行菌群采集和评估以监测孕产妇菌群状态；
    步骤二，在菌群检测合格的孕产妇进入产房后，使用所述菌群采集辅助装置在剖宫产手术进行前采集产妇阴道菌群，将采集到的孕产妇菌群一部分直接涂抹接生医生或接生护士的手术手套，在取出胎儿时接生医生或接生护士穿戴涂抹有孕产妇菌群的手术手套，使刚离开母体的刨宫产新生儿立即接触到母体菌群，尤其需要注意让新生儿直接将手术手套上的部分孕产妇菌群通过口腔吸入腹部进入其肠道；采集到的孕产妇菌群的另外一部分放入培养皿中，让无菌棉花和医用手套充分获得菌群，在新生儿成功分娩取出后交给护士处置胎盘和脐带时，该护士可用医用手套来操作，而在新生儿称完体重进行包裹时，用已经获得母体菌群的无菌棉进行皮肤涂抹，并同时涂抹妈妈的乳头，以最大化减少分娩时新生儿未经产道的菌群缺失。
    步骤三，用所述菌群采集辅助装置采集新生儿胎便，进行粪菌高通量测序，即进行新生儿胎便菌群采集，并使用所述母婴菌群传递监测系统对采集到的新生儿胎便菌群进行菌群评估，当评估结果为健康菌群组时，给出无需再次涂抹并继续保持的建议，并持续进行菌群采集和评估以监测新生儿菌群状态；所述评估结果为缺失菌群组时，给出需经过再次涂抹或益生菌补充定植建议，并在调节后持续进行菌群采集和评估以监测新生儿菌群状态；所述评估结果为致病菌群组时，给出需经过益生菌调节并积极治疗的建议，且持续进行菌群采集和评估以监测新生儿菌群状态。
  10. 根据权利要求9所述的母婴菌群传递监测方法，其特征在于，所述步骤二中进行产妇菌群采集时，将所述产妇菌群在培养皿中留样和发酵，以便于与新生儿胎便菌群进行涂抹时能保持足够使用，也可用于菌群检测。
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