WO2021153319A1 - サーモ内視鏡を有する光温熱治療装置 - Google Patents

サーモ内視鏡を有する光温熱治療装置 Download PDF

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Publication number
WO2021153319A1
WO2021153319A1 PCT/JP2021/001527 JP2021001527W WO2021153319A1 WO 2021153319 A1 WO2021153319 A1 WO 2021153319A1 JP 2021001527 W JP2021001527 W JP 2021001527W WO 2021153319 A1 WO2021153319 A1 WO 2021153319A1
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WO
WIPO (PCT)
Prior art keywords
irradiation
thermal image
imaging means
thermography
temperature
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2021/001527
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English (en)
French (fr)
Japanese (ja)
Inventor
広夫 内田
祐司 守本
信介 野村
大谷　淳
睦月 尾原
賢 正宗
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tokai National Higher Education and Research System NUC
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Tokai National Higher Education and Research System NUC
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Filing date
Publication date
Application filed by Tokai National Higher Education and Research System NUC filed Critical Tokai National Higher Education and Research System NUC
Priority to KR1020227024800A priority Critical patent/KR20220152995A/ko
Priority to US17/790,326 priority patent/US20230043393A1/en
Priority to EP21748450.0A priority patent/EP4098320A4/en
Priority to JP2021574649A priority patent/JPWO2021153319A1/ja
Publication of WO2021153319A1 publication Critical patent/WO2021153319A1/ja
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0082—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes
    • A61B5/0084—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes for introduction into the body, e.g. by catheters
    • A61B5/0086—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes for introduction into the body, e.g. by catheters using infrared radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N5/0601—Apparatus for use inside the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N5/0613—Apparatus adapted for a specific treatment
    • A61N5/0625—Warming the body, e.g. hyperthermia treatment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/00002—Operational features of endoscopes
    • A61B1/00004—Operational features of endoscopes characterised by electronic signal processing
    • A61B1/00006—Operational features of endoscopes characterised by electronic signal processing of control signals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/00002—Operational features of endoscopes
    • A61B1/00043—Operational features of endoscopes provided with output arrangements
    • A61B1/00045—Display arrangement
    • A61B1/0005—Display arrangement combining images e.g. side-by-side, superimposed or tiled
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/04—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor combined with photographic or television appliances
    • A61B1/046—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor combined with photographic or television appliances for infrared imaging
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/04—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor combined with photographic or television appliances
    • A61B1/05—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor combined with photographic or television appliances characterised by the image sensor, e.g. camera, being in the distal end portion
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
    • A61B18/20—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser
    • A61B18/203—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser applying laser energy to the outside of the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/01—Measuring temperature of body parts ; Diagnostic temperature sensing, e.g. for malignant or inflamed tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/01—Measuring temperature of body parts ; Diagnostic temperature sensing, e.g. for malignant or inflamed tissue
    • A61B5/015—By temperature mapping of body part
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6846—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive
    • A61B5/6847—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive mounted on an invasive device
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N5/0601—Apparatus for use inside the body
    • A61N5/0603—Apparatus for use inside the body for treatment of body cavities
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N5/0613—Apparatus adapted for a specific treatment
    • A61N5/062—Photodynamic therapy, i.e. excitation of an agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N5/067—Radiation therapy using light using laser light
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N2005/0626—Monitoring, verifying, controlling systems and methods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N2005/063—Radiation therapy using light comprising light transmitting means, e.g. optical fibres
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N2005/0658—Radiation therapy using light characterised by the wavelength of light used
    • A61N2005/0659—Radiation therapy using light characterised by the wavelength of light used infrared
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N2005/0658—Radiation therapy using light characterised by the wavelength of light used
    • A61N2005/0662—Visible light

Definitions

  • the present invention relates to a photothermia treatment device having a thermoendoscope.
  • thermography imaging means is incorporated in an endoscope in order to measure the surface temperature of a tissue in a body cavity.
  • thermography imaging means By using such a thermography imaging means, it is possible to track and grasp the heating status of the lesion tissue.
  • doctors at the surgical site it has been extremely difficult for doctors at the surgical site to properly use the thermography.
  • the doctor at the surgical site will perform photothermal treatment while looking at both the endoscopic image and the thermographic thermal image, so he can accurately grasp the correspondence between the endoscopic image and the thermal image and quickly and accurately. It was extremely difficult to make a diagnosis.
  • the thermal image changes from moment to moment as the light irradiation progresses, there is a complexity that the output and time of the light irradiation must be appropriately controlled in response to this, which makes the above-mentioned difficulty. It was increasing even more.
  • an object of the present invention is to provide a photothermia treatment apparatus capable of easily grasping a temperature change of a lesioned tissue and easily and appropriately heating the tissue at a predetermined temperature and a predetermined time.
  • the photothermia treatment apparatus 100 includes an elongated probe 10, an operation unit 20 arranged on the proximal end side of the probe 10, and a probe 10. It has a communication module 30 arranged between the operation units 20.
  • the probe 10 has a cylindrical shape with a diameter of about 14 mm and a length of about 200 mm.
  • the diameter and length can be changed as needed.
  • the diameter of the probe 10 can be changed in the range of preferably 3 to 20 mm, more preferably in the range of 5 to 16 mm.
  • a diameter of about 14 mm is the most preferable size.
  • the length of the probe 10 can also be changed preferably in the range of 150 to 250 mm, more preferably in the range of 180 to 220 mm.
  • the length of about 200 mm is the most preferable size.
  • An endoscopic objective lens 40, an infrared thermography objective lens 50, and a collimating lens 60 for laser irradiation are arranged at the tip of the probe 10.
  • Infrared rays radiated from the observation area in the body cavity are received by the thermopile element through the infrared thermography objective lens 50 and the infrared filter behind it, and are converted into electrical energy. Then, the electric energy is sent to the image processing means 70 by the communication module 30.
  • the endoscopic image in the body cavity captured by the endoscopic objective lens 40 and the CCD element behind it and the thermal image of infrared thermography are displayed on the monitor 80 in FIG.
  • the endoscopic image and the thermal image can be displayed separately on the monitor 80, but by switching the switch, the endoscopic image and the thermal image are combined by the image processing means 70 and superposed on the monitor 80. It can also be displayed on.
  • the superimposed display is realized by adjusting by software so that the optical axes of the endoscopic image and the thermal image are displaced so as to be substantially overlapped with each other.
  • the target temperature is 50 ° C.
  • the laser output can be PID controlled in the range of 43 ° C. to 100 ° C., more preferably in the range of 43 ° C. to 90 ° C., and most preferably in the range of 80 ° C.
  • the image processing means 70 in the control PC extracts 9x9 pixels around the highest temperature pixel from the thermal image of FIG. 5 (a) as shown in FIG. 5 (b), and this is approximated to a two-dimensional Gaussian function. Then, as shown in FIG. 5C, the maximum temperature of the Gaussian distribution is regarded as the tumor temperature, and PID control is performed based on the tumor temperature. Further, PID control may be performed based on the average temperature within a predetermined region of the thermal image (for example, within the 9x9 pixel region).
  • FIG. 6 shows the change in the tumor temperature at the time of actual light heating for rat liver tumor, and it was confirmed that the tumor temperature can be controlled within the range of ⁇ 5 ° C of the target temperature of 50 ° C.
  • the doctor at the surgical site can easily check the state in which the thermal image is superimposed on the endoscopic image or the state in which both images are displayed separately on the monitor 80, so that even a subtle temperature difference can be easily recognized and the light can be seen.
  • the laser beam can be quickly and accurately positioned with respect to the target tissue in the body cavity where the sensitizer is excited by accurate probe operation.
  • Probe 20 Operation unit 30: Communication module 40: Endoscopic objective lens 50: Thermography objective lens 60: Collimating lens 70: Image processing means 80: Monitor 90: Laser fiber 100: Photothermal treatment device 110: Trocar

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Surgery (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Biophysics (AREA)
  • Radiology & Medical Imaging (AREA)
  • Optics & Photonics (AREA)
  • Electromagnetism (AREA)
  • Otolaryngology (AREA)
  • Signal Processing (AREA)
  • Radiation-Therapy Devices (AREA)
  • Laser Surgery Devices (AREA)
  • Endoscopes (AREA)
PCT/JP2021/001527 2020-01-31 2021-01-18 サーモ内視鏡を有する光温熱治療装置 Ceased WO2021153319A1 (ja)

Priority Applications (4)

Application Number Priority Date Filing Date Title
KR1020227024800A KR20220152995A (ko) 2020-01-31 2021-01-18 서모 내시경을 갖는 광온열 치료 장치
US17/790,326 US20230043393A1 (en) 2020-01-31 2021-01-18 Light/heat treatment device having thermo-endoscope
EP21748450.0A EP4098320A4 (en) 2020-01-31 2021-01-18 LIGHT/HEAT TREATMENT DEVICE INCLUDING A THERMO-ENDOSCOPE
JP2021574649A JPWO2021153319A1 (https=) 2020-01-31 2021-01-18

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2020014371 2020-01-31
JP2020-014371 2020-01-31

Publications (1)

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WO2021153319A1 true WO2021153319A1 (ja) 2021-08-05

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PCT/JP2021/001527 Ceased WO2021153319A1 (ja) 2020-01-31 2021-01-18 サーモ内視鏡を有する光温熱治療装置

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US (1) US20230043393A1 (https=)
EP (1) EP4098320A4 (https=)
JP (1) JPWO2021153319A1 (https=)
KR (1) KR20220152995A (https=)
WO (1) WO2021153319A1 (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116269171B (zh) * 2023-03-23 2025-11-04 钜嘉联合科技股份有限公司 热图像内窥镜系统、其异常区域显示方法及显示装置、及热图像处理计算机

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH02203871A (ja) * 1989-01-31 1990-08-13 Asahi Optical Co Ltd レーザ治療用測温内視鏡
JP2000079089A (ja) 1998-09-07 2000-03-21 Olympus Optical Co Ltd 内視鏡用サーモグラフィー装置
JP2003010110A (ja) * 2001-07-04 2003-01-14 Olympus Optical Co Ltd 撮像装置
JP2007528239A (ja) * 1995-08-31 2007-10-11 バイオレーズ テクノロジー インコーポレイテッド 組織除去装置およびその方法
JP2017020932A (ja) * 2015-07-13 2017-01-26 新日鐵住金株式会社 ガラス繊維強化プラスチック製設備の保全評価方法
JP2017518784A (ja) * 2014-05-20 2017-07-13 ヴェリリー ライフ サイエンシズ エルエルシー レーザアブレーション手術用のシステム

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7179222B2 (en) * 1996-11-20 2007-02-20 Olympus Corporation Fluorescent endoscope system enabling simultaneous achievement of normal light observation based on reflected light and fluorescence observation based on light with wavelengths in infrared spectrum
US20180279864A1 (en) * 2002-03-12 2018-10-04 Beth Israel Deaconess Medical Center Protoporphyrin ix (ppix) imaging
JP3930359B2 (ja) * 2002-03-29 2007-06-13 オリンパス株式会社 センチネルリンパ節検出装置及び検出方法
IL154101A0 (en) * 2003-01-23 2003-07-31 Univ Ramot Minimally invasive controlled surgical system with feedback
WO2015061588A1 (en) * 2013-10-23 2015-04-30 The Trustees Of Dartmouth College Surgical vision augmentation system
EP3474735A4 (en) * 2016-06-27 2020-01-08 Ramot at Tel-Aviv University Ltd. MONITORING TISSUE TREATMENT BY THERMOGRAPHY
KR101852439B1 (ko) * 2016-09-01 2018-04-27 광주과학기술원 열화상에 기반한 병변 탐지용 내시경 장치
US11719818B2 (en) * 2017-03-16 2023-08-08 Trinamix Gmbh Detector for optically detecting at least one object

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH02203871A (ja) * 1989-01-31 1990-08-13 Asahi Optical Co Ltd レーザ治療用測温内視鏡
JP2007528239A (ja) * 1995-08-31 2007-10-11 バイオレーズ テクノロジー インコーポレイテッド 組織除去装置およびその方法
JP2000079089A (ja) 1998-09-07 2000-03-21 Olympus Optical Co Ltd 内視鏡用サーモグラフィー装置
JP2003010110A (ja) * 2001-07-04 2003-01-14 Olympus Optical Co Ltd 撮像装置
JP2017518784A (ja) * 2014-05-20 2017-07-13 ヴェリリー ライフ サイエンシズ エルエルシー レーザアブレーション手術用のシステム
JP2017020932A (ja) * 2015-07-13 2017-01-26 新日鐵住金株式会社 ガラス繊維強化プラスチック製設備の保全評価方法

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of EP4098320A4

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Publication number Publication date
KR20220152995A (ko) 2022-11-17
US20230043393A1 (en) 2023-02-09
JPWO2021153319A1 (https=) 2021-08-05
EP4098320A1 (en) 2022-12-07
EP4098320A4 (en) 2024-02-14

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