WO2021147212A1

WO2021147212A1 - Continuous flow reaction module and reaction device, and filling block

Info

Publication number: WO2021147212A1
Application number: PCT/CN2020/089540
Authority: WO
Inventors: 杨凯; 杨勇; 宁萌; 周在国
Original assignee: 南通微著智能科技有限公司
Priority date: 2020-01-20
Filing date: 2020-05-11
Publication date: 2021-07-29
Also published as: CN111111602A

Abstract

A continuous flow reaction module and reaction device, and a filling block. The reaction module comprises an outer tube body (1), and multiple first filling blocks (2) and second filling blocks (3) alternately fixed in an inner cavity of the outer tube body (1). Through holes (21) which are consistent with the direction of a tube cavity of the outer tube body (1) are provided on end surfaces of the first filling blocks (2). Multiple grooves (31) which are consistent with the direction of the tube cavity of the outer tube body (1) are provided on side walls of the second filling blocks (3). The reaction liquid flows into the tube cavity through one end of the outer tube body (1), and then flows into a downstream cavity through the through holes (21) on the first filling blocks (2), is radially divided outward by the cavity, flows to the downstream cavity through the grooves (31) on the second filling blocks (3), and then flows to the downstream cavity though the through holes (21) on the first filling blocks (2), and then circulates according to the sequence.

Description

Continuous flow reaction module, reaction device and packing

Technical field

The present invention relates to the field of continuous flow reaction devices. Specifically, it relates to a reaction module that can promote the mixing effect of fluids in a continuous flow process, as well as a device equipped with the continuous flow reaction module and the continuous flow reaction device. Important stuffing block parts in the module.

Background technique

Tubular reactors and tank reactors are currently commonly used fluid reaction equipment in the chemical and pharmaceutical fields.

Among them, the tank reactor is generally equipped with a stirring device in the reactor for mixing liquid phase reactants, which has the problems of low synthetic purity, low reaction conversion rate, and more serious energy consumption and pollution. Because the chemical and pharmaceutical fields have high requirements for product purity, continuous flow tubular reactors are relatively more types of reaction equipment.

In view of the fact that the chemical reactant concentration and reaction rate in the tubular reactor vary with the length of the tube. Therefore, in order to achieve the required effect, the tubular reactor is generally provided with a tube length that needs to meet the requirements of the chemical reaction. In order to ensure the effect, if the existing straight tube reactor or U-shaped tube reactor needs to set a longer tube length inside, the volume of the entire reactor must be large enough. In addition, because the flow state of the reactants in the reaction tube will directly affect the uninterrupted mixing effect and the heat transfer rate of the reaction, in order to avoid the excessive volume of the reaction device, relevant designs are urgently needed to ensure that the tube length is basically unchanged. Next, the purpose of improving the mixing effect and reaction rate is achieved by changing the internal structure of the pipeline.

Summary of the invention

The present invention provides a continuous flow reaction module, which, compared with the existing tubular reactor, can achieve the purpose of improving the mixing effect of the continuous flow liquid under the condition that the tube length is basically the same. Moreover, the continuous flow reaction module has a simple structure and is easy to manufacture, process and install. This patent also relates to a device using the continuous flow reaction module and a packing placed in the continuous flow reaction module to change the liquid flow pattern and mixed flow mode.

The technical solution adopted by the present invention to solve its technical problems is: a continuous flow reaction module, comprising an outer tube body and a plurality of packing blocks 1 and 2 alternately fixed in the inner cavity of the outer tube, the packing blocks 1. The side wall of the second packing is in contact with the inner wall of the outer tube body.

A common solution is that for each packing block set in the lumen of the outer tube, a packing block 2 is set accordingly. Therefore, the number of packing blocks set in the entire outer tube body is the same as or different from the number of packing blocks 2. One, at the same time, in the direction of liquid flow (that is, from upstream to downstream), the axial distance between the filler one and the second filler can be uniform, or it can be continuously larger or smaller, depending on specific requirements. It can be flexibly determined according to the viscosity and reaction conditions of the liquid.

At least one through hole capable of conducting the two end surfaces is provided between the two end faces of the filler one, and the axial direction of the through hole can be along the axial direction of the filler one or along the axial direction of the outer tube body, or It can be in other forms.

The side walls of the second packing block are provided with a plurality of grooves that can conduct the two ends. The extending direction of the grooves can be along the axial direction of the packing block two or along the axial direction of the outer tube body, or other form. After the side walls of the second packing block are in contact with the inner wall of the lumen of the outer tube body, the grooves on the two side walls of the packing block enclose the inner wall of the outer tube body to form a slot hole.

After the reaction liquid flows into the lumen from one end of the outer tube body, it flows into the cavity formed between the first packing block and the downstream adjacent packing block through the through hole provided on the first packing block. It diverges outwards and flows downstream through the grooves on the side walls of the two packing blocks, that is, it enters the cavity formed between the two packing blocks and the downstream adjacent packing one. Then, the through holes of the downstream filler block one flow to the cavity formed between the downstream filler block two, and the cycle is carried out in sequence as described above. The design of the flow dynamics of the reaction liquid in this way enables the reaction liquid to be continuously mixed and reacted in a continuous flow by means of a converging and dispersing rectification form, so as to achieve the purpose of improving the mixing effect of the continuously flowing liquid. Therefore, in order to ensure that the reaction liquid circulates from the axial center of the lumen to the radial outer end and then converges to the axial center, the circulation flow process of dispersing to the radial outer end can promote the mixing effect as much as possible. Ground the position of the through hole provided on the first filler block close to or at the axis of the first filler block.

In order to enable as many packing blocks as possible to be contained in the outer tube per unit length, while ensuring the smooth flow of the reaction liquid, in specific implementation, both ends of the packing block one can be made into spherical grooves, and at the same time, The two ends of the packing block are also spherical groove-shaped. This arrangement can make the cavity formed between the opposing surfaces of the adjacent packing block 1 and the packing block into a waist drum shape, increase the volume of the cavity, and facilitate the full progress of the reaction liquid in the cyclically converging and dispersed flow process Mix in order to fully react.

If a through hole is provided on the first filler block, the two ports of the through hole are respectively at the center positions of the two end faces of the filler block one. In other words, the axis of the through hole is at the axis of the filler block one at this time. At the center, the axis of the through hole is preferably close to coincide with the axis of the filler block one.

If there are multiple through holes on the first filler block, it can be divided into the following situations: (1) The axis of one through hole is at the axis of the first filler block, and the other through holes are distributed on all the through holes. The outer periphery of the axial center of the first packing block; (2) All the through holes are arranged on the outer periphery of the axial center of the first packing block.

In the above two cases, if there is a through hole provided at the first axis of the filling block, the axis of the through hole should be along the axis of the first filling block. If not, skip it. At the same time, any through hole provided on the periphery of the axis of the filler block makes the axis of this type of through hole obliquely arranged with respect to the axis of the filler block one and makes the axis of this type of through hole located at the downstream end of the The axis of the filling block one.

Generally speaking, the extending direction of the groove provided on the two side walls of the packing block is consistent with the axial direction of the packing block 2, that is, the projection of the groove extending direction on the vertical plane is consistent with the axis of the packing block 2. The heart lines are relatively parallel or coincident. However, in some embodiments, the projection on the vertical plane of the extending direction of the groove provided on the two sidewalls of the packing block crosses the axis of the second packing block. The vertical plane referred to is generally understood as the vertical plane of the axis line of the second overfill block. If it is understood as the parallel plane that is relatively parallel or relatively perpendicular to the vertical plane of the axis line of the second overfill block, the extension direction of the groove needs to be changed. It is understood that it is projected onto the vertical plane together with the axis of the filling block two. What needs to be appealing is that the inclination directions of the grooves provided on two adjacent packing blocks (with one packing block one in the middle) set in the same outer tube body can be opposite, so that the flow direction of the reaction liquid in the radial direction can be changed continuously. To further improve the mixing effect of the reaction liquid.

In other embodiments, the grooves provided on the two side walls of the filler block can be spiral grooves. Setting the groove as a spiral groove can make the reaction liquid form turbulent flow, increase the flow rate, and make the different components in the reaction liquid be in a certain separated state and then converge and mix in the axial direction, which can further improve the mixing effect. Moreover, the spiral directions of the grooves provided on the two adjacent packing blocks (with one packing block one in the middle) arranged in the same outer tube body can be reversed, and the mixing of the reaction liquid can be better improved by continuously changing the swirling direction. The purpose of the effect. It is also possible to make the spiral direction of the grooves on the second partial packing block arranged in sequence along the flow direction of the reaction liquid consistent (such as a clockwise spiral), and the spiral direction of the grooves on the second partial packing block arranged in sequence next is the same as the previous one. On the contrary (counterclockwise spiral), the spiral direction of the grooves on the next part of the filling block 2 is opposite to the previous one (clockwise spiral), and the setting is repeated in this way. In the so-called partial filling block 1 or filling block 2, the number of filling blocks referred to by the "partial" includes the case of coincidence and the case of inconsistency. The spiral curves of grooves with the same spiral direction can be different.

In actual implementation, in the lumen of the outer tube body, if the packing block one has a different specific structure style or the packing block two has a different specific structure style, or the packing block one and the two packing block both have different specific structure styles, then When arranging two filling blocks, under the premise that each filling block is set, one filling block two is set. The specific structure styles of the two filling blocks one on both sides of the same filling block two can be different, or they can be in the same filling block. The specific structure styles of the two filler blocks on one side and the two sides can be different, or the structure styles of the two filler blocks on both sides of the same filler block are different, and the structure styles of the two filler blocks on both sides of the same filler block are different. Or along the flow direction of the reaction liquid, the structure pattern of the partially packed block one arranged in sequence is one, and the structure style of the partially packed block one arranged in sequence is another one, and the two adjacent blocks are placed correspondingly at this time. The structure styles of the multiple packing blocks between the packing block one can be one or multiple; or along the flow direction of the reaction liquid, the partial packing block two arranged in sequence have one structure style, and then they are arranged in sequence The structure style of the partial filling block 2 is another type. At this time, the structure styles of the multiple filling blocks 1 correspondingly placed between the two adjacent filling blocks 2 can be one or multiple, and so on. The arrangement forms of the filling block 1 and the filling block 2 fall within the protection scope of the independent claims of the continuous flow reaction module in this patent.

In addition, (1) "Including the outer tube body and a plurality of packing blocks 1 and 2 alternately fixed in the inner cavity of the outer tube" should be understood as: a. Each one is provided in the lumen of the outer tube body The case where one or more filler blocks are set accordingly as soon as the filler block; b. It also includes the situation where one or more filler blocks two are set correspondingly every time two or more filler blocks are successively set, or every time two or more filler blocks are successively set One or more filling block two situations are set accordingly. Especially when there are multiple specific structural styles of the filling block one (mainly referring to the arrangement form of the through holes), there are many specific structural styles of the filling block two (mainly referring to the arrangement form of the groove). (2) Regarding "the side wall of the second packing block is provided with a plurality of grooves consistent with the direction of the lumen of the outer tube" should be understood as: a. Not only includes the diameter opened on the side surface of the second packing block When the cross-section is triangular, trapezoidal, U-shaped, or]-shaped or other irregular or regular-shaped notches; b. It should also be considered to include the customary filling blocks set near the inner circle of the two side walls of the filling blocks. The slot on the end surface, and the radial cross-sectional shape of the slot includes any shape.

A continuous flow reaction device, which contains a certain form of continuous flow reaction module mentioned above, that is, the continuous flow reaction device may contain only one form of continuous flow reaction module mentioned above, or simultaneously Contains the various types of continuous flow reaction modules mentioned above.

A filling block, at least one of the upper end surface and the lower end surface of the filling block is in the shape of a spherical groove.

In one solution, at least one through hole capable of conducting the two end surfaces is provided between the two end surfaces of the filling block.

Specifically, only one through hole is provided between the two end faces of the filling block, and the two ports of the through hole respectively correspond to the centers of the two end faces of the filling block.

Specifically, a plurality of through holes are provided between the two end faces of the packing block, the axis of one of the through holes corresponds to the shaft center of the packing block, and the other through holes are distributed and arranged on the periphery of the shaft center of the packing block; or The through holes are distributed around the axis of the packing block.

Preferably, the axis of the through hole provided at the periphery of the shaft center of the filler block is inclined with respect to the axial center of the filler block and the downstream port is close to the shaft center of the filler block.

In another solution, a plurality of grooves capable of conducting both ends of the filler block are provided on the side wall of the filler block.

Specifically, the projection of the extending direction of the groove provided on the side wall of the filler block on the vertical plane intersects the axis line of the filler block or the groove is set as a spiral groove.

In this patent, when understanding the direction (extension direction) of the mentioned groove, the expression that defines the groove along the axial direction of the packing should be understood as containing the groove extending direction which is relatively parallel to the axial direction of the packing or intersecting the projection. The situation (the extending direction of the spiral groove can be understood as a two-port connection).

The so-called end surface is spherical groove shape, that is, an arc surface groove is formed on the end surface, and the arc surface can be an arc surface with an outer center, or it may be composed of multiple arc surfaces with multiple outer centers and/or inner centers Of coherent arcs.

Beneficial effects: Compared with the existing tubular reactor, the continuous flow reaction module provided by the present invention can achieve the purpose of improving the mixing effect and reaction rate of the continuously flowing liquid under the condition that the tube length is basically the same. Moreover, the continuous flow reaction module contains fewer types of accessories, has a simpler structure, is easy to process, and requires simple processes when assembled together after being separately processed and manufactured. Therefore, the continuous flow reaction module is convenient to manufacture, has low cost, and is beneficial. For maintenance and replacement. The continuous flow reaction device using the continuous flow reaction module can reduce the overall volume of the device while achieving the same mixing effect, and the purchase cost of the reaction tube can be reduced.

Description of the drawings

Figure 1 is a schematic cross-sectional structure diagram of the continuous flow reaction module involved in the patent scheme.

Fig. 2 is a schematic cross-sectional structure diagram of the first embodiment of the filling block involved in the patent scheme.

3 is a schematic cross-sectional structure diagram of the first embodiment of the second packing block involved in the patent scheme.

Fig. 4 is a schematic top view of the structure of the first embodiment of the filling block involved in the patent scheme.

Fig. 5 is a schematic top view of the structure of the first embodiment of the second filling block involved in the patent scheme.

FIG. 6 is a schematic diagram of the three-dimensional structure of the first embodiment of the filling block involved in the patent scheme.

FIG. 7 is a schematic diagram of the three-dimensional structure of the second embodiment of the second filling block involved in the patent scheme.

FIG. 8 is a schematic cross-sectional structure diagram of the second embodiment of the first embodiment of the packing block involved in the patent scheme.

Fig. 9 is a schematic top view of the second embodiment of the filling block involved in the patent scheme.

FIG. 10 is a schematic diagram of the third cross-sectional structure of the second embodiment of the packing block involved in the patent scheme.

FIG. 11 is a schematic diagram of the front view structure of the fourth embodiment of the second filling block involved in the patent scheme.

In the picture: 1 outer tube body, 2 filling block one, 21 through hole, 3 filling block two, 31 slot

Detailed ways

The structure, ratio, size, etc. shown in the drawings of the specification are only used to match the content disclosed in the specification for the understanding and reading of those who are familiar with the technology. They are not used to limit the implementation conditions of the present invention, so they do not have The technical significance, any structural modification, proportional relationship change or size adjustment, shall still fall within the technical content disclosed in the present invention without affecting the effects and objectives that can be achieved by the present invention. Within the range that can be covered. At the same time, terms such as "upper", "lower", "front", "rear", "middle" and other terms cited in this specification are only for ease of description and are not used to limit the scope of the present invention. , The change or adjustment of the relative relationship shall be regarded as the scope of the implementation of the present invention without substantial changes to the technical content.

As shown in Figure 1, a continuous flow reaction module includes an outer tube body 1 and a plurality of packing

blocks

1 and 2 and 2 packing blocks alternately fixed in the inner cavity of the outer tube body 1. The packing blocks 1, 2, The side walls of the second packing 3 are in contact with the inner wall of the outer tube body 1. The thermal assembly process is often used to make the side wall of the packing block and the inner wall of the outer tube body pressed together to ensure that the packing block does not move relative to the lumen during use. Of course, if the outer tube body is a structure with half-pipes on both sides buckled together, then it is also possible to set a holding band at the position corresponding to the packing block outside the outer tube body so that the side wall of the packing block and the inner wall of the outer tube body are pressed together . The outer tube body referred to can be understood as a plurality of unit tubes connected together in sequence by a threaded structure or a plug-in structure. At this time, the opposite ends of the two unit tubes that are connected should conform to the filling block of the whole outer tube body. And the alternate arrangement rule of filling block two. The outer tube body is set in the form of a unit, which can be easily assembled, and it is convenient to put the packing block into the tube, and it is convenient to grasp the axial distance between two adjacent packing blocks during operation. In the specific assembly process, the operation of sequentially connecting the filler blocks into a whole through the connecting ribs in advance is not excluded, and then one piece is stuffed into the outer tube body or the unit tube.

In actual implementation, as shown in Figure 1, each packing block 1 2 is set in the lumen of the outer tube body 1, and a packing block 2 3 is set accordingly. Therefore, the number of packing blocks 1 2 set in the entire outer tube body 1 is equal to The number of filler blocks 2 and 3 is the same, or there is one more filler block or one more filler block 2. In the direction of liquid flow (that is, the direction from upstream to downstream), the axial distance between the first and second fillers can be uniform, or it can be continuously larger or smaller, or even It is partly consistent and partly relatively larger or smaller, and the specific needs to be flexibly determined according to the viscosity of the liquid and the reaction conditions.

At least one through hole 21 is provided on the end surface of the packing block 2 that is consistent with the direction (axial direction) of the lumen of the outer tube body 1, and the through hole 21 can conduct the two ends of the packing block 2. The side wall of the second packing 3 is provided with a plurality of grooves 31 that are consistent with the direction (axial direction) of the lumen of the outer tube body 1, and the grooves 31 can conduct the two end surfaces of the second packing 3. After the side walls of the two packing blocks 3 are in contact with the inner wall of the outer tube body 1, the grooves 31 on the side walls of the two packing blocks 3 and the inner wall of the outer tube body 1 are enclosed to form Slot holes.

The through hole 21 may be a cylindrical hole as shown in the figure, or may be a conical hole, a triangular hole, a prismatic hole, or a special-shaped hole.

The radial cross-sectional shape of the groove 31 may be a U-shape as shown in the figure, or may be a V-shape or a trapezoid shape or a tooth groove (groove meshing with gear teeth) shape or the like.

As shown in FIG. 1, the axial directions of the filler blocks 2 and 3 are consistent with the axial direction of the outer tube body 1. After the reaction liquid flows into the lumen from one end of the outer tube body 1, it flows into the cavity formed between the packing block 2 and its downstream adjacent packing block 2 through the through hole 21 provided on the packing block 1, and then by The cavity diverges radially outwards and flows downstream through the groove 31 on the side wall of the packing block 2, that is, into the cavity formed between the packing block 2 3 and its downstream adjacent packing block 2. Then, the through holes 21 of the downstream filler one 2 flow to the cavity formed between it and the downstream adjacent filler two 3, and then the cycle proceeds in the above sequence. The design of the flow form of the reaction liquid in this way can make the reaction liquid continuously mix and react with the aid of a rectification form that converges toward the center and disperses radially to the periphery during the continuous flow process, so as to improve the continuous flow. The purpose of the mixing effect of the liquid. Therefore, in order to ensure that the reaction liquid circulates from the axial center of the lumen to the radial outer end and then converges to the axial center, the circulation flow process of dispersing to the radial outer end can promote the mixing effect as much as possible. Possibly, the position of the through hole 21 provided on the filling block 1 is close to or at the axis of the filling block 2 (the axis of the through hole shown in FIG. 1 coincides with the axis of the filling block 1).

In order to make the unit length of the outer tube body can contain as many packing blocks as possible, and at the same time to ensure the smooth flow of the reaction liquid, as shown in Figures 1 to 11, the two ends of the packing block 2 are made to be spherical grooves. At the same time, both ends of the two filling blocks 3 are spherical and groove-shaped. This arrangement can make the cavity formed between the opposing surfaces of the adjacent packing block 1 and the packing block into a waist drum shape, increase the volume of the cavity, and facilitate the full progress of the reaction liquid in the cyclically converging and dispersed flow process Mix in order to fully react. On the one hand, it can smoothly make the reaction liquid converge toward the center, and on the other hand, it makes the radially outwardly dispersed climb to a certain extent, so that part of the reaction liquid has reflux and can continue to mix with the liquid flowing in later. The so-called end surface is spherical groove shape, that is, an arc surface groove is formed on the end surface, and the arc surface can be an arc surface with one outer center (in various cases shown in the figure), or it may have multiple outer centers and/or A continuous arc composed of multiple arcs at the center of the inner circle.

As shown in Fig. 2, Fig. 4, and Fig. 6, a through hole 21 is provided along the axis of the filler block 2. The arcs of the grooves formed by the two ends (A ₁ surface and A _{2 surface) of the packing block 2 are basically the same.}

As shown in FIG. 3 and FIG. 5, a plurality of grooves 31 are alternately arranged on the side wall of the second filler block 3, and the direction of the grooves 31 is consistent with the axial direction of the second filler block 3. As shown in FIG. 6, the groove 31 provided on the side wall is inclined, and the extension line of the direction intersects the projection of the axial direction (line) of the filler block 2 3 in the vertical plane. The arcs of the grooves formed on the two end faces (B ₁ face and B _{2 face) of the two filler blocks are basically the same.}

Comparing Fig. 2 and Fig. 3, it can be seen that _{the groove arc formed by the end faces (A 1} surface, A ₂ surface) of packing block one 2 is the groove formed by the end faces (B ₁ face, B ₂ surface) of packing block two 3. The arc is different. In practical applications, it is also possible to make the groove arc formed by _{the end faces (A 1} surface, A ₂ _{surface) of the block one 2 and the end faces (B 1} surface, B ₂ surface) of the block two 3 to form a groove arc shape same.

As shown in FIG. 9, the arc of the groove formed on _{the B 1} _{surface of the filler block 2} is different from the arc of the groove formed on the B 2 surface. In the same way, the _{arc of the groove formed on the A 1} surface of the packing block 2 and the arc of the groove formed on the A ₂ surface may also be different.

As shown in Figure 1, Figure 2, Figure 4, and Figure 6, if a through hole 21 is provided on the filler block 1, the axis of the through hole 21 is at the axis of the filler block 2, and The axis of the through hole 21 is set to coincide with the axis of the filling block-2.

As shown in Figures 8 and 9, the packing block 2 is provided with a plurality of through holes, and the axis of one of the through holes 21 is at the axis of the packing block 2, and the other through holes 21 are distributed in The outer periphery of the axis of the filling block one forms a circle (in addition to the circle shown in the figure, it can also be triangular, polygonal, etc.). It is also possible to make the arrangement of other through holes relative to the through holes at the axis to form a word, or arranged in a "+" sign, or arranged in an "x" sign, and so on.

In addition, if a plurality of through holes are provided on the packing block 1, all the through holes can be arranged on the periphery of the shaft center of the packing block one to form one or more circles, or to form a triangle or form a circle Polygons, or arranged to form a word, arranged in a "=" sign, arranged in a "+" sign, or arranged in a "x" sign, etc.

As shown in Fig. 8, for the through hole 21 provided on the periphery of the axis of the packing block-2, it is better to make the axis of this type of through hole oblique to the axial direction of the packing block-2 and make the type of through hole The one end of the axis at the downstream side is close to the axis of the filler one.

Generally speaking, as shown in Figure 1, Figure 3, and Figure 5, the extending direction of the groove 31 provided on the side wall of the filler block 2 3 is consistent with the axial direction of the filler block 2 3, that is, the direction of the groove 31 The projection of the extension direction (line) on the vertical plane is relatively parallel or coincides with the axis line of the filler block two 3. However, in some embodiments in practical applications, the projection on the vertical plane of the extending direction (line) of the groove provided on the two side walls of the filling block crosses the axis line of the two filling block (as shown in the figure). 7). The vertical plane referred to is generally understood as the vertical plane of the axis line of the second overfill block. If it is understood as the parallel plane that is relatively parallel or relatively perpendicular to the vertical plane of the axis line of the second overfill block, the extension direction of the groove needs to be changed. (Line) is projected onto the vertical plane together with the axis line of the filling block 2 to understand. What needs to be appealing is that the inclination directions of the grooves provided on two adjacent packing blocks (with one packing block one in the middle) set in the same outer tube body can be opposite, so that the flow direction of the reaction liquid in the radial direction can be changed continuously. To further improve the mixing effect of the reaction liquid.

As shown in Fig. 11, the grooves 31 provided on the side walls of the two filler blocks 3 can also be spiral grooves. Setting the groove 31 as a spiral groove can cause the reaction liquid to form turbulent flow, increase the flow rate, and separate the different components in the reaction liquid and then converge in the axial direction, which can further improve the mixing effect. Moreover, the spiral directions of the grooves provided on the two adjacent packing blocks (with one packing block one in the middle) arranged in the same outer tube body can be reversed, and the mixing of the reaction liquid can be better improved by continuously changing the swirling direction. The purpose of the effect.

In actual implementation, if block one has a different specific structure style (as shown in Figure 2, Figure 8) or block two and three have different specific structure styles (as shown in Figure 3, Figure 7, Figure 10, Figure 11)), or Filling block 1 and filling block 2 both have different specific structure styles (as shown in Figure 2, Figure 8, Figure 3, Figure 7, Figure 10, Figure 11), so when arranging the two filling blocks, follow each set of filling blocks Under the premise of setting the rule of one filling block two, at the same time, the specific structure styles of two filling blocks one on both sides of the same filling block two can be different, or the two filling blocks two on both sides of the same filling block can be different. The specific structure style can be different.

A continuous flow reaction device, which includes the continuous flow reaction module shown in Fig. 1, and also includes a new scheme structure formed by replacing the packing blocks with different specific structures shown in Figs. 2 to 11 in Fig. 1 The continuous flow reaction module.

As shown in Fig. 2 to Fig. 11, the upper end surface and the lower end surface of the packing block are both spherical and groove-shaped. The so-called end surface is spherical groove shape, that is, an arc surface groove is formed on the end surface, and the arc surface can be an arc surface with one outer center (in various cases shown in the figure), or it may have multiple outer centers and/or A continuous arc composed of multiple arcs at the center of the inner circle.

One way, as shown in Figure 2, Figure 3, Figure 4, Figure 8, Figure 9, the end face of the filler block is provided with at least one through hole 21 along the axial direction, and both ends of the filler block can use the through hole 21 The hole can be turned on.

The packing block may only be provided with one through hole 21 and the axis of the through hole 21 is at the axis of the packing block, as shown in FIG. 2, FIG. 4, and FIG. 6.

The packing block may also be provided with a plurality of through holes 21, of which the axis of one through hole 21 corresponds to the shaft center of the packing block, and the other through holes are distributed and arranged on the periphery of the shaft center of the packing block, as shown in Figure 8-9. Or, all the through holes 21 are distributed on the periphery of the shaft center of the packing block. The axis of the through hole 21 provided on the periphery of the shaft center of the filler block is inclined with respect to the axial center of the filler block and the downstream port is close to the shaft center of the filler block, as shown in FIG. 8.

In another way, see Fig. 3, Fig. 5, Fig. 7, and Fig. 10, a plurality of grooves 31 having the same axial direction are provided on the side wall of the packing block. The two ends of the filler block can be conducted through the groove, and a plurality of independent conduction channels are formed.

The projection of the extending direction of the groove 31 provided on the side wall of the filler block on the vertical plane intersects the axis line of the filler block, as shown in Fig. 7; or the groove 31 is set as a spiral groove, as shown in Fig. 11.

In this patent, when understanding the direction of the axis of the through hole mentioned, the expression that defines the through hole along the axial direction of the filler should be understood as containing the direction of the axis of the through hole opposite to the axial direction of the filler. Parallel or coincident situations, and situations where the axis of the through hole is inclined relative to the axial direction of the packing (including the situation where the downstream end of the axis of the through hole is close to or far from the axis of the packing). When understanding the direction (extension direction) of the mentioned groove, the expression defining the groove along the axial direction of the packing should be understood as including the situation where the extending direction of the groove and the axial direction of the packing are relatively parallel or the projection intersects (spiral groove The extension direction of can be understood as a two-port connection).

The above-mentioned embodiments only exemplarily illustrate the principles and effects of the present invention, and are not used to limit the present invention. There are many aspects of the present invention that can be improved without departing from the general idea. Those familiar with the technology can modify or change the above-mentioned embodiments without departing from the spirit and scope of the present invention. Therefore, all equivalent modifications or changes made by those with ordinary knowledge in the technical field without departing from the spirit and technical ideas disclosed in the present invention should still be covered by the claims of the present invention.

Claims

A continuous flow reaction module, which is characterized in that it comprises an outer tube body and a plurality of packing blocks one and two alternately fixed in the inner cavity of the outer tube; the side walls of the packing block one and the packing block two and The inner wall of the outer tube is in contact with the inner wall of the outer tube; at least one through hole is provided between the two end faces of the first packing block that can communicate with the two end faces; the side wall of the second packing block is provided with multiple ends that can conduct the two end faces of the packing block. Slots.
The continuous flow reaction module according to claim 1, characterized in that: both end faces of the first packing block and the two end faces of the packing block two are in the shape of spherical grooves; or, in the first packing block and the second packing block two. In the seed packing, choose one of the two ends of the seed packing to have a spherical groove shape.
The continuous flow reaction module according to claim 2, wherein only one through hole is provided on the first packing block, and two ports of the through hole are respectively located at the center of the two ends of the packing block one.
The continuous flow reaction module according to claim 2, wherein the projection of the extending direction of the grooves provided on the two side walls of the packing block on the vertical plane intersects the axis of the second packing block.
The continuous flow reaction module according to claim 2, wherein the grooves provided on the two side walls of the packing block are spiral grooves.
The continuous flow reaction module according to claim 2, wherein a plurality of through holes are provided on the first filling block, and the axis of one through hole corresponds to the axis of the first filling block, and the other through holes are distributed It is arranged on the periphery of the axis of the first packing block, or all the through holes are distributed on the periphery of the axis of the packing block one.
The continuous flow reaction module according to claim 6, wherein the axis of the through hole provided on the periphery of the axial center of the packing block is inclined with respect to the axial direction of the packing block one and the downstream end is close to the Fill the axis of block one.
The continuous flow reaction module according to claim 1, wherein a through hole is provided on the first packing block, and two ports of the through hole are respectively located at the center of two ends of the packing block one.
The continuous flow reaction module according to claim 1, wherein the projection of the extending direction of the groove provided on the two side walls of the packing block on the vertical plane intersects the axis of the second packing block.
The continuous flow reaction module according to claim 1, wherein the grooves provided on the two side walls of the packing block are spiral grooves.
The continuous flow reaction module according to claim 1, wherein a plurality of through holes are provided on the first filling block, and the axis of one through hole corresponds to the axis of the first filling block, and the other through holes are distributed It is arranged on the periphery of the axis of the first packing block, or all the through holes are arranged on the periphery of the axis of the packing block one.
The continuous flow reaction module according to claim 11, wherein the axis of the through hole provided on the periphery of the axial center of the packing block is inclined with respect to the axial direction of the packing block one and the downstream port is close to the Fill the axis of block one.
A continuous flow reaction device, characterized in that it contains at least one type of continuous flow reaction module referred to in claims 1-12.
A packing block, characterized in that: at least one of the two end faces of the packing block is in the shape of a spherical groove, and at least one through hole capable of conducting the two end faces is arranged between the two end faces of the packing block.
The packing block according to claim 14, wherein only one through hole is provided on the packing block and the two ports of the through hole are respectively located at the center of the two ends of the packing block.
The packing block according to claim 14, characterized in that: the packing block is provided with a plurality of through holes, the axis of one of the through holes corresponds to the axis of the packing block, and the other through holes are distributed in the packing block. The periphery of the shaft center; or, all the through holes are distributed on the periphery of the shaft center of the packing block.
The packing block according to claim 16, wherein the axis of the through hole provided on the periphery of the packing block shaft center is inclined with respect to the shaft center of the packing block and the downstream port is close to the shaft center of the packing block.
A packing block, characterized in that: at least one of the two end faces of the packing block is in the shape of a spherical groove; the side wall of the packing block is provided with a plurality of grooves which can conduct the two ends of the packing block.
The packing block according to claim 18, wherein the projection of the extending direction of the groove provided on the side wall of the packing block on the vertical plane intersects the axis line of the packing block.
The packing block according to claim 18, wherein the groove provided on the side wall of the packing block is a spiral groove.