WO2021145316A1 - Granular agricultural chemical composition for rice seedling raising box with which harmful effects are reduced - Google Patents

Abstract

[Problem] To provide a granular agricultural chemical composition for a rice seedling raising box with which harmful effects are reduced. [Solution] A granular agricultural chemical composition for a rice seedling raising box, the composition being characterized by containing an agricultural chemical active ingredient, an alkyl naphthalene sulfonate derivative, an alphanized starch, and a smectite mineral.

Description

Rice seedling box application pesticide granule composition with reduced phytotoxicity

The present invention relates to a pesticide granule composition applied to a rice seedling raising box with reduced phytotoxicity, and a method for producing the same.

Technical background

When using pesticides, it is preferable to reduce the amount or frequency of use of pesticides from the viewpoint of labor saving and reduction of environmental load. In response to such a request, in transplanted paddy rice cultivation, the pesticide used in Honda is applied to the nursery box, and after transplantation, the seedling raising box treatment is performed so that the effect is exhibited in Honda. However, when the seedlings are treated with ordinary granular pesticides, the pesticide active ingredients or other components that are eluted or released may cause phytotoxicity such as delayed growth or poor growth of the seedlings. Therefore, it is desired to develop a seedling raising box treatment agent that does not cause or reduce phytotoxicity to young seedlings during the raising of seedlings.

So far, pesticide preparations have been reported for the purpose of suppressing the elution of the pesticide active ingredient and reducing the phytotoxicity due to the contact between the seedlings and the pesticide active ingredient in the nursery box (Patent Documents 1, 2 and 3). As a method other than elution control, a pesticide preparation aimed at reducing seedling phytotoxicity by adding a specific substance has also been reported (Patent Document 4).

Japanese Unexamined Patent Publication No. 2012-11752 Japanese Patent Publication No. 2012-508713 Japanese Unexamined Patent Publication No. 2012-17271 Japanese Unexamined Patent Publication No. 2009-221108

An object of the present invention is to provide a pesticide-formulated composition having an excellent phytotoxicity-reducing effect on a pesticide active ingredient having a high risk of poor growth of rice seedlings.

Means to solve problems

The present inventors have found that a pesticide granule composition for rice seedling box application containing a pesticide active ingredient, an alkylnaphthalene sulfonic acid derivative, pregelatinized starch, and smectite mineral has an excellent effect of reducing chemical damage, and the present inventors have found that the present invention has an excellent effect of reducing chemical damage. It came to be completed.

The present invention provides the following solutions.

[1] A pesticide granule composition for rice seedling raising box, which contains a pesticide active ingredient, an alkylnaphthalene sulfonic acid derivative, pregelatinized starch, and smectite mineral.

[2] The pesticide granule composition according to [1], wherein the content ratio of the pesticide active ingredient is 1 to 30% by weight.

[3] The pesticide granule composition according to [1] or [2], wherein the content ratio of the alkylnaphthalene sulfonic acid derivative is 0.1 to 2.0% by weight.

[4] The pesticide granule composition according to any one of [1] to [3], wherein the content ratio of pregelatinized starch is 0.1 to 10% by weight.

[5] The pesticide granule composition according to any one of [1] to [4], wherein the smectite mineral is bentonite.

[6] The pesticide granule composition according to any one of [1] to [5], wherein the content ratio of smectite mineral is 1 to 50% by weight.

The pesticide granular composition of the present invention can reduce phytotoxicity caused by a component containing a pesticide active ingredient when applied to a rice seedling raising box.

The present invention provides a pesticide granule composition for rice seedling box application, which comprises a pesticide active ingredient, an alkylnaphthalene sulfonic acid derivative, a smectite mineral, and pregelatinized starch.

The pesticide active ingredient according to the present invention is an insecticide, an acaricide, a nematode, a fungicide, a fungicide, a mollusk repellent, a microbial agent, a beneficial organism, a squash apple mussel, a herbicide, a bird repellent, and a plant. Means fortifiers, herbicides, information chemicals and / or plant growth regulators.

Insecticides / Acaricides / Nematodes The active ingredients identified by "generic name" herein are known and, for example, "The Pesticide Manual", 16th ed., British Crop. It is described in "Protection Council 2012" or can be searched on the Internet (for example, "http://www.alanwood.net/pesticides"). The classification is based on the "IRAC Mode of Action Classification Scene" applicable at the time of filing of this patent application.

(1) Acetylcholinesterase (AChE) inhibitor, for example
Carbamates, such as aranicalb, aldicarb, benziocarb, benfuracarb, butocarboxim, butoxycarboxym, carbyl, carbofuran, carbosulfan, etiophencarb, phenocarb, formanate, fratiocarb, isoprocarb, methiocarb, methomyl, metolcarb, oxamil, pyrimicurve, propox. , Thiodicarb, thiofanox, triazamate, trimetacarb, XMC, and xylylcarb; or
Organic phosphates such as acephate, azamethiphos, azinephos-ethyl, azinephos-methyl, kazusaphos, chlorethoxyphos, chlorphenbinphos, chlormefos, chlorpyriphos-methyl, kumaphos, cyanophos, dimethoate-S-methyl, diazinon, dichlorvos. / DDVP, dichlorvos, dimethoate, dimethylbinphos, disulfoton, EPN, ethion, etopros, famfur, phenamiphos, fenitrothione, fenthion, hostiazet, heptenophos, imisiaphos, isophenphos, O- (methoxyaminothiophosphoryl) isopropyl salicylate, isoxathione, malathion Mecarbam, metamidphos, methidathione, mevinphos, monochlorotophos, naredo, ometoate, oxydimethoate-methyl, palatine-methyl, fentoate, holate, hosalon, phosmet, phosphamide, hoxime, pyrimiphos-methyl, prophenofos, propetumphos, prothiophos, pyraclophos, pyridafenthion. Kinalphos, sulfotep, tebupyrimphos, temefos, terbuhos, tetrachlorvos, thiometon, triazophos, trichlorfon, and bamidthione.

(2) GABA-controlled chloride channel blockers, such as
Cyclodiene-organochlorine systems, such as chlordan and endosulfan; or
Phenylpyrazole-based (fiprol-based), such as etiprol and fipronil.

(3) Sodium channel modulator, for example
Pyrethroids, such as acrinathrin, allethrin, d-cis-transarethrin, d-transallethrin, bifenthrin, bioallethrin, bioallethrin S-cyclopentenyl isomer, bioresmethrin, cycloprothrin, cypermethrin, beta-cypermethrin, cypermethrin -Cypermethrin, gamma-cypermethrin, cypermethrin, alpha-cypermethrin, beta-cypermethrin, theta-cypermethrin, zeta-cypermethrin, cypermethrin [(1R) -trans isomer], deltamethrin, empentrin [(EZ)- (1R) isomer], esphenvalerate, etofenprox, fenpropatrin, fenvalerate, flucitrinate, flumethrin, tau-fluvalinate, halphenprox, imiprothrin, cadetrin, monfluorothrin, permethrin, phenothrin [( 1R) -trans isomer], prarethrin, pyrethrins (pyrethrum), allethrin, cypermethrin, tefluthrin, tetramethrin, tetramethrin [(1R) isomer], tralomethrin, and transfluthrin; or
DDT; or methoxychlor.

(4) Nicotinic acetylcholine receptor (nAChR) competitive modulators, such as
Neonicotinoids, such as acetamiprid, clothianidin, dinotefuran, imidacloprid, nitenpyram, thiacloprid, and thiamethoxam; or
Nicotine; or
Sulfoxaflor or flupyradiflon.

(5) Nicotinic acetylcholine receptor (nAChR) allosteric modulator, for example
Spinosads, such as spinetram and spinosad.

(6) Glutamic acid controlled chloride channel (GluCl) allosteric modulator, eg
Avermectin / milbemycin, such as abamectin, emamectin benzoate, repimectin, and milbemectin.

(7) Juvenile hormone mimics, such as
Juvenile hormone analogs such as hydroprene, quinoprene, and methoprene; or
Phenoxycarb; or pyriproxyfen.

(8) Various unspecified (multisite) inhibitors, such as
Alkylated alkyl halides, such as methyl bromide and another alkyl halide; or
Chloropicrin; or sulfuryl fluoride; or borax; or liquor stone, or
Methyl isocyanate producers such as diazomet and metam.

(9) String organ modulator, for example
Pimetrodin; or Flonicamid.

(10) Tick growth inhibitor, for example
Clofentezine, hexitiazox, and difluorovidadine; or
Etoxazole.

(11) A microbial disruptor of the insect midgut membrane, eg
Bacillus thuringiensis subspecies israelensis, Bacillus thuringiensis subspecies, Bacillus thuringiensis subspecies, Bacillus thuringiensis subspecies, Bacillus thuringiensis subspecies, Bacillus thuringiensis subspecies, Bacillus thuringiensis subspecies, Bacillus thuringiensis subspecies, Bacillus thuringiensis subspecies islaelsis Subspecies Bacillus thuringiensis subspecies kurstaki, Bacillus thuringiensis subspecies tenebrionis, Bacillus thuringiensis subspecies tenebriois, and BtAcy 105, Cry2Ab, Vip3A, mCry3A, Cry3Ab, Cry3Bb, Cry34Ab1 / 35Ab1.

(12) Inhibitors of mitochondrial ATP synthase, such as ATP disruptors, such as
Diafenthiuron; or
Organic tin compounds such as azocyclotin, cyhexatin, and fenbutatin oxide; or
Propargite; or tetradiphon.

(13) A decoupling agent for oxidative phosphorylation by disrupting the proton gradient, eg
Chlorfenapyr, DNOC, and sulfuramide.

(14) Nicotinic acetylcholine receptor channel blockers, such as
Bensultap, Cartap hydrochloride, thiocyclum, and thiosultap-sodium.

(15) Inhibitors of chitin biosynthesis (type 0), eg
Bistrifluron, chlorflubenzuron, diflubenzuron, flucycloxuron, fulphenoxuron, hexaflumron, lufenuron, novalron, nobiflumron, teflubenzuron, and triflubenzuron.

(16) Inhibitors of chitin biosynthesis (type 1), eg
Buprofezin.

(17) Moulting disruptors (especially in the case of Diptera), for example
Cyromazine.

(18) Ecdysone receptor agonists, eg
Chromaphenozide, halophenozide, methoxyphenozide, and tebufenozide.

(19) Octopamine receptor agonists, eg
Amitraz.

(20) Mitochondrial complex III electron transfer inhibitor, eg,
Hydramethylnon; or acequinocyl; or fluacrypyrim.

(21) Mitochondrial complex I electron transfer inhibitor, eg,
METI acaricides such as phenazakin, phenpyroximate, pyrimidiphen, pyridaben, tebufenpyrado, and tolfenpyrad; or
Rotenone (Derris).

(22) Voltage-gated sodium channel blockers, such as
Indoxacarb; or metaflumizone.

(23) Inhibitors of acetyl-CoA carboxylase, such as
Tetrolic acid derivatives and tetramic acid derivatives, such as spirodiclofen, spiromesiphen, and spirotetramato.

(24) Mitochondrial complex IV electron transfer inhibitor, eg,
Phosphine systems, such as aluminum phosphide, calcium phosphide, phosphine, and zinc phosphide;
Cyanide, calcium cyanide, potassium cyanide, and sodium cyanide.

(25) Mitochondrial complex II electron transfer inhibitor, eg,
β-ketonitrile derivatives such as sienopyraphen and siflumethofen and carboxyanilides such as pifrubmid.

(28) Ryanodine receptor modulator, eg,
Diamides, such as chloranthraniliprole, cyantraniliprole, flubendiamide, tetraniliprole and tetrachlorantraniliprole.

Additional active ingredients, such as afidopyropen, afoxoleiner, azadilactin, imprufluxam, bencrothias, benzoximate, biphenazate, brofranylide, bromopropirate, quinomethionate, chloroprallythrin, cryolite c. , Cyclaniliprol, cycloxaprid, cyhalodiamide, dichloromezotiaz, dicohol, ε-methylofluthrin, ε-methylfluthrin, ε-momlyolite ), Fluenesulfone, Fluphenerim, Fluphenoxystrobin, Flufiprol, Fluhexafon, Fluopirum, Flularanel, Fluxamethamide, Fufenozide, Guadipyr, Guadipyr, Heptafluthrin, Imidacrotiz, -Tefluthrin, lotilaner, meperfurthrin, paichongding, pyridalyl, pyrifluquinazone, pyriminostrobin, spirobudiclofen, tetramethylfluthrin, thioxazaphen, thiofluoxymate Mesopyridine and iodomethane; further, preparations based on Bacillus filament (I-1582, BioNeem, Votivo), and the following compounds: 1- {2-fluoro-4-methyl-5- [(2,2,2-trifluoroethyl) sulfinyl] phenyl} -3- (trifluoromethyl) -1H-1,2,4-triazole-5-amine (known from WO2006 / 043635) (CAS 885026-50) -6), {1'-[(2E) -3- (4-chlorophenyl) propa-2-ene-1-yl] -5-fluorospiro [indole-3,4'-piperidine] -1 (2H) -Il} (2-chloropyridin-4-yl) methanone (known from WO2003 / 106457) (CAS 673360-23-7) , 2-Chloro-N- [2- {1-[(2E) -3- (4-chlorophenyl) propa-2-ene-1-yl] piperidin-4-yl} -4- (trifluoromethyl) phenyl ] Isonicotinamide (known from WO2006 / 03494) (CAS 872999-66-1), 3- (4-chloro-2,6-dimethylphenyl) -4-hydroxy-8-methoxy-1,8-diazaspiro [4] .5] Deca-3-en-2-one (known from WO20100052161) (CAS 1225292-17-0), 3- (4-chloro-2,6-dimethylphenyl) -8-methoxy-2-oxo-1 , 8-Diazaspiro [4.5] Deca-3-en-4-yl ethylcarbonate (known from EP2467626) (CAS-1440516-42-6), 4- (Buta-2-in-1-yloxy)- 6- (3,5-Dimethylpiperidine-1-yl) -5-fluoropyrimidine (known from WO2004 / 099160) (CAS 792914-58-0), PF1364 (known from JP2010 / 018586) (CAS Reg. No. 1204776-60-2), N-[(2E) -1-[(6-chloropyridine-3-yl) methyl] pyridine-2 (1H) -iriden] -2,2,2-trifluoroacetamide (WO2012) (Known from / 029672) (CAS 1363400-41-2), (3E) -3- [1-[(6-chloro-3-pyridyl) methyl] -2-pyridylidene] -1,1,1-trifluoropropane -2-one (known from WO2013 / 144213) (CAS 1461743-15-6), N- [3- (benzylcarbamoyl) -4-chlorophenyl] -1-methyl-3- (pentafluoroethyl) -4- ( Trifluoromethyl) -1H-pyrazol-5-carboxamide (known from WO2010 / 051926) (CAS 1226889-14-0), 5-bromo-4-chloro-N- [4-chloro-2-methyl-6- ( Methylcarbamoyl) phenyl] -2- (3-chloro-2-pyridyl) pyrazole-3-carboxamide (known from CN103232431) (CAS 1449220-44-3), 4- [5- (3,5-dichlorophenyl) -4 , 5-Dihydro-5- (trifluoromethyl) -3-isooxazolyl] -2-methyl-N- (cis-1-oxide-3-thietanyl) benzamide, 4- [5- (3,5-dichlorophenyl)- 4,5-Dihydro-5- (trifluoromethyl) -3-isooxazolyl] -2-methyl-N- (trans-1-oxide-3-thietanyl) benzamide and 4-[(5S) -5- (3) 5-Dichlorophenyl) -4,5-dihydro-5- (trifluoromethyl) -3-isooxazolyl] -2-methyl-N- (cis-1-oxide-3-thietanyl) benzamide (known from WO2013 / 050317A1) ( CAS 132628-83-7), N- [3-chloro-1- (3-pyridinyl) -1H-pyrazol-4-yl] -N-ethyl-3-[(3,3,3-trifluoropropyl) Sulfinyl] propanamide, (+)-N- [3-chloro-1- (3-pyridinyl) -1H-pyrazol-4-yl] -N-ethyl-3-[(3,3,3-trifluoropropyl) ) Sulfinyl] propanamide and (-)-N- [3-chloro-1- (3-pyridinyl) -1H-pyrazol-4-yl] -N-ethyl-3-[(3,3,3-trifluoro) Propyl) sulfinyl] Lopanamide (known from WO2013 / 162715A2, WO2013 / 162716A2, US2014 / 0213448A1) (CAS 1477923-37-7), 5-[[(2E) -3-chloro-2-propen-1-yl] amino] -1- [2,6-dichloro-4- (trifluoromethyl) phenyl] -4-[(trifluoromethyl) sulfinyl] -1H-pyrazole-3-carboxamide (known from CN101337937A) (CAS 1105672-77-2), 3-Bromo-N- [4-chloro-2-methyl-6-[(methylamino) thioxomethyl] phenyl] -1- (3-chloro-2-pyridinyl) -1H-pyrazole-5-carboxamide, (Liudaibenjiaxuanan, Known from CN103109816A) (CAS 1232543-85-9); N- [4-chloro-2-[[(1,1-dimethylethyl) amino] carbonyl] -6-methylphenyl] -1- (3-chloro- 2-Pyridinyl) -3- (fluoromethoxy) -1H-pyrazole-5-carboxamide (known from WO2012 / 0344403A1) (CAS 1268277-22-0), N- [2- (5-amino-1,3,4) -Thiazazole-2-yl) -4-chloro-6-methylphenyl] -3-bromo-1- (3-chloro-2-pyridinyl) -1H-pyrazole-5-carboxamide (known from WO2011 / 085575A1) (CAS 1233882-22-8), 4- [3- [2,6-dichloro-4-[(3,3-dichloro-2-propen-1-yl) oxy] phenoxy] propoxy] -2-methoxy-6- (Trifluoromethyl) pyrimidine (CN101337940A) (known from CAS 1108184-52-6); (2E)-and 2 (Z) -2- [2- (4-cyanophenyl) -1- [3- (trifluoro) Methyl) phenyl] ethylidene] -N- [4- (difluoromethoxy) phenyl] hydrazine carboxamide (known from CN1017175774A) (CAS 1232543-85-9); cyclopropanecarboxylic acid 3- (2,2-dichloroethenyl) -2 , 2-Dimethyl-4- (1H-benzimidazol-2-yl) phenylester (known from CN103524422A) (CAS 1542271-46-4); (4aS) -7-chloro-2,5-dihydro-2-[ [(Methylcarbonyl) [4-[(trifluoromethyl) thio] phenyl] amino] carbonyl] indeno [1,2-e] [1,3,4] oxadiadin-4a (3H) -carboxylic acid methyl ester (CN102391261A) Known from) (CAS 1370358-69-2); 6-deoxy-3-O-ethyl-2,4-di-O-methyl-1- [N- [4- [1- [4- (1,1) , 2,2,2-Pentafluoroethoxy) phenyl] -1H-1,2,4-triazol-3-yl] phenyl] carbamate] -α-L-mannopyranose (known from US2014 / 0275503A1) (CAS 1181213 14-8); 8- (2-Cyclopropylmethoxy-4-trifluoromethylphenoxy) -3- (6-trifluoromethylpyridazine-3-yl) -3-azabicyclo [3.2.1] octane (3.2.1) CAS 1253855-56-4), (8-anti) -8- (2-cyclopropylmethoxy-4-trifluoromethylphenoxy) -3- (6-trifluoromethylpyridazine-3-yl) -3-azabicyclo [ 3.2.1] Octane (CAS 933798-27-7), (8-sin) -8- (2-cyclopropylmethoxy-4-trifluoromethylphenoxy) -3- (6-trifluoromethylpyridazine-3) -Il) -3-azabicyclo [3.2.1] octane (known from WO2007040280A1, WO2007040282A1) (CAS 934001-66-8), and N- [3-chloro-1- (3-pyridinyl) -1H- Pyrazole-4-yl] -N-ethyl-3-[(3,3,3-trifluoropropyl) thio] propanoamide (known from WO2015 / 058021A1, WO2015 / 058028A1) (CAS 1477919-27-9).

Fungicide The active ingredient identified by the "generic name" herein is known and is described, for example, in "Pesticide Manual" (16th Ed., British Crop Protection Council). Alternatively, it can be searched on the Internet (for example, "http://www.alanwood.net/pesticides").

All components described in classes (1)-(15) can optionally form salts with suitable bases or acids based on their functional groups. All fungicide mixture components described in classes (1)-(15) may optionally include tautomeric morphology.

(1) Inhibitors of ergosterol biosynthesis, such as (1.001) cyproconazole, (1.002) diphenoconazole, (1.003) epoxyconazole, (1.004) fenhexamide, (1. 005) phenpropidine, (1.006) phenpropimorph, (1.007) fenpyrazamine, (1.08) flukinconazole, (1.009) flutriazole, (1.010) imazalyl, (1. 011) Imazaryl Sulfate, (1.012) Ipconazole, (1.013) Metoconazole, (1.014) Microbutanyl, (1.015) Paclobutrazole, (1.016) Prochloraz, (1.017) Propico Nazole, (1.018) prothioconazole, (1.019) pyrisoxazole, (1.020) spiroxamine, (1.021) tebuconazole, (1.022) tetraconazole, (1.023) triazimenol, (1.024) Tridemorph, (1.025) Triticonazole, (1.026) (1R, 2S, 5S) -5- (4-chlorobenzyl) -2- (chloromethyl) -2-methyl-1 -(1H-1,2,4-triazole-1-ylmethyl) cyclopentanol, (1.027) (1S, 2R, 5R) -5- (4-chlorobenzyl) -2- (chloromethyl) -2 -Methyl-1- (1H-1,2,4-triazole-1-ylmethyl) cyclopentanol, (1.028) (2R) -2- (1-chlorocyclopropyl) -4-[(1R)- 2,2-Dichlorocyclopropyl] -1- (1H-1,2,4-triazole-1-yl) butane-2-ol (1.029) (2R) -2- (1-chlorocyclopropyl)- 4-[(1S) -2,2-dichlorocyclopropyl] -1- (1H-1,2,4-triazole-1-yl) butane-2-ol, (1.030) (2R) -2- [4- (4-Chlorophenoxy) -2- (trifluoromethyl) phenyl] -1- (1H-1,2,4-triazole-1-yl) propan-2-ol, (1.031) (2S) ) -2- (1-Chlorocyclopropyl) -4-[(1R) -2,2-dichlorocyclopropyl] -1- (1H-1,2,4-triazole-1-yl) butane-2-ol , (1.032) (2S) -2- (1-chlorocyclopropyl) -4-[(1S) -2,2-dichlorocyclopropyl] -1- (1H-1,2, 4-Triazole-1-yl) butane-2-ol, (1.033) (2S) -2- [4- (4-chlorophenoxy) -2- (trifluoromethyl) phenyl] -1- (1H-) 1,2,4-Triazole-1-yl) propan-2-ol, (1.034) (R)-[3- (4-chloro-2-fluorophenyl) -5- (2,4-difluorophenyl) ) -1,2-oxazol-4-yl] (pyridine-3-yl) methanol, (1.035) (S)-[3- (4-chloro-2-fluorophenyl) -5- (2,4) -Difluorophenyl) -1,2-oxazol-4-yl] (pyridine-3-yl) methanol, (1.036) [3- (4-chloro-2-fluorophenyl) -5- (2,4-) Difluorophenyl) -1,2-oxazol-4-yl] (pyridine-3-yl) methanol, (1.037) 1-({(2R, 4S) -2- [2-chloro-4- (4-) Chlorophenoxy) phenyl] -4-methyl-1,3-dioxolan-2-yl} methyl) -1H-1,2,4-triazole, (1.038) 1-({(2S, 4S) -2- [2-Chloro-4- (4-chlorophenoxy) phenyl] -4-methyl-1,3-dioxolan-2-yl} methyl) -1H-1,2,4-triazole, (1.039) 1- {[3- (2-Chlorophenyl) -2- (2,4-difluorophenyl) oxylan-2-yl] methyl} -1H-1,2,4-triazole-5-ylthiocyanate, (1.040) 1 -{[Rel (2R, 3R) -3- (2-chlorophenyl) -2- (2,4-difluorophenyl) oxylan-2-yl] methyl} -1H-1,2,4-triazole-5-yl Thiosianate, (1.041) 1-{[rel (2R, 3S) -3- (2-chlorophenyl) -2- (2,4-difluorophenyl) oxylan-2-yl] methyl} -1H-1,2 , 4-Triazole-5-ylthiocyanate, (1.042) 2-[(2R, 4R, 5R) -1- (2,4-dichlorophenyl) -5-hydroxy-2,6,6-trimethylheptan-4 -Il] -2,4-dihydro-3H-1,2,4-triazole-3-thione, (1.043) 2-[(2R, 4R, 5S) -1- (2,4-dichlorophenyl)- 5-Hydroxy-2,6,6-trimethylheptane-4-yl] -2,4-dihydro-3H-1,2 , 4-Triazole-3-thione, (1.044) 2-[(2R, 4S, 5R) -1- (2,4-dichlorophenyl) -5-hydroxy-2,6,6-trimethylheptan-4- Il] -2,4-dihydro-3H-1,2,4-triazole-3-thione, (1.045) 2-[(2R, 4S, 5S) -1- (2,4-dichlorophenyl) -5 -Hyoxy-2,6,6-trimethylheptan-4-yl] -2,4-dihydro-3H-1,2,4-triazole-3-thione, (1.046) 2-[(2S, 4R, 5R) -1- (2,4-dichlorophenyl) -5-hydroxy-2,6,6-trimethylheptan-4-yl] -2,4-dihydro-3H-1,2,4-triazole-3-thione , (1.047) 2-[(2S, 4R, 5S) -1- (2,4-dichlorophenyl) -5-hydroxy-2,6,6-trimethylheptan-4-yl] -2,4-dihydro -3H-1,2,4-triazole-3-thione, (1.048) 2-[(2S, 4S, 5R) -1- (2,4-dichlorophenyl) -5-hydroxy-2,6,6 -Trimethylheptan-4-yl] -2,4-dihydro-3H-1,2,4-triazole-3-thione, (1.049) 2-[(2S, 4S, 5S) -1- (2) 4-Dichlorophenyl) -5-hydroxy-2,6,6-trimethylheptan-4-yl] -2,4-dihydro-3H-1,2,4-triazole-3-thione, (1.050) 2- [1- (2,4-Dichlorophenyl) -5-hydroxy-2,6,6-trimethylheptan-4-yl] -2,4-dihydro-3H-1,2,4-triazole-3-thione, ( 1.051) 2- [2-chloro-4- (2,4-dichlorophenoxy) phenyl] -1- (1H-1,2,4-triazole-1-yl) propan-2-ol, (1. 052) 2- [2-chloro-4- (4-chlorophenoxy) phenyl] -1- (1H-1,2,4-triazole-1-yl) butane-2-ol, (1.053) 2- [4- (4-chlorophenoxy) -2- (trifluoromethyl) phenyl] -1- (1H-1,2,4-triazole-1-yl) butane-2-ol, (1.054) 2- [4- (4-chlorophenoxy) -2- (trifluoromethyl) phenyl] -1- (1H-1,2,4-triazole-1-yl) pentan-2-ol, ( 1.055) 2- [4- (4-Chlorophenoxy) -2- (trifluoromethyl) phenyl] -1- (1H-1,2,4-triazole-1-yl) propan-2-ol, ( 1.056) 2-{[3- (2-Chlorophenyl) -2- (2,4-difluorophenyl) oxylan-2-yl] methyl} -2,4-dihydro-3H-1,2,4-triazole -3-Thion, (1.057) 2-{[rel (2R, 3R) -3- (2-chlorophenyl) -2- (2,4-difluorophenyl) oxylan-2-yl] methyl} -2, 4-Dihydro-3H-1,2,4-triazole-3-thione, (1.058) 2-{[rel (2R, 3S) -3- (2-chlorophenyl) -2- (2,4-difluoro) Phenyl) oxylan-2-yl] methyl} -2,4-dihydro-3H-1,2,4-triazole-3-thione, (1.059) 5- (4-chlorobenzyl) -2- (chloromethyl) ) -2-Methyl-1- (1H-1,2,4-triazole-1-ylmethyl) cyclopentanol, (1.060) 5- (allyl sulfanyl) -1-{[3- (2-chlorophenyl) -2- (2,4-difluorophenyl) oxylan-2-yl] methyl} -1H-1,2,4-triazole, (1.061) 5- (allyl sulfanyl) -1-{[rel (2R,) 3R) -3- (2-chlorophenyl) -2- (2,4-difluorophenyl) oxylan-2-yl] methyl} -1H-1,2,4-triazole, (1.062) 5- (allyl sulfanyl) ) -1-{[rel (2R, 3S) -3- (2-chlorophenyl) -2- (2,4-difluorophenyl) oxylan-2-yl] methyl} -1H-1,2,4-triazole, (1.063) N'-(2,5-dimethyl-4-{[3- (1,1,2,2-tetrafluoroethoxy) phenyl] sulfanyl} phenyl) -N-ethyl-N-methylimideformamide , (1.064) N'-(2,5-dimethyl-4-{[3- (2,2,2-trifluoroethoxy) phenyl] sulfanyl} phenyl) -N-ethyl-N-methylimideformamide, (1.065) N'-(2,5-dimethyl-4-{[3- (2,2,3,3-tetrafluoropropoxy) phenyl] sulfanyl} phenyl) -N-ethyl-N-methylimideformamide , (1.066) N'-(2,5-ji Methyl-4-{[3- (pentafluoroethoxy) phenyl] sulfanyl} phenyl) -N-ethyl-N-methylimideformamide, (1.067) N'-(2,5-dimethyl-4- {3- [(1,1,2,2-Tetrafluoroethyl) sulfanyl] phenoxy} phenyl) -N-ethyl-N-methylimideformamide, (1.068) N'-(2,5-dimethyl-4- {3) -[(2,2,2-trifluoroethyl) sulfanyl] phenoxy} phenyl) -N-ethyl-N-methylimideformamide, (1.069) N'-(2,5-dimethyl-4- {3- [(2,2,3,3-tetrafluoropropyl) sulfanyl] phenoxy} phenyl) -N-ethyl-N-methylimideformamide, (1.070) N'-(2,5-dimethyl-4- {3) -[(Pentafluoroethyl) sulfanyl] phenoxy} phenyl) -N-ethyl-N-methylimideformamide, (1.071) N'-(2,5-dimethyl-4-phenoxyphenyl) -N-ethyl-N -Methylimideformamide, (1.072) N'-(4-{[3- (difluoromethoxy) phenyl] sulfanyl} -2,5-dimethylphenyl) -N-ethyl-N-methylimideformamide, (1. 073) N'-(4- {3-[(difluoromethyl) sulfanyl] phenoxy} -2,5-dimethylphenyl) -N-ethyl-N-methylimideformamide, (1.074) N'-[5- Bromo-6- (2,3-dihydro-1H-inden-2-yloxy) -2-methylpyridine-3-yl] -N-ethyl-N-methylimideformamide, (1.075) N'-{4 -[(4,5-Dichloro-1,3-thiazole-2-yl) oxy] -2,5-dimethylphenyl} -N-ethyl-N-methylimideformamide, (1.076) N'-{5 -Bromo-6-[(1R) -1- (3,5-difluorophenyl) ethoxy] -2-methylpyridine-3-yl} -N-ethyl-N-methylimideformamide, (1.077) N' -{5-Bromo-6-[(1S) -1- (3,5-difluorophenyl) ethoxy] -2-methylpyridine-3-yl} -N-ethyl-N-methylimideformamide, (1.078) ) N'-{5-bromo-6-[(cis-4-isopropylcyclohexyl) oxy] -2-methylpyridine-3-yl} -N-ethyl -N-Methylimideformamide, (1.079) N'-{5-bromo-6-[(trans-4-isopropylcyclohexyl) oxy] -2-methylpyridine-3-yl} -N-ethyl-N- Methylimideformamide, (1.080) N'-{5-bromo-6- [1
-(3,5-Difluorophenyl) ethoxy] -2-methylpyridine-3-yl} -N-ethyl-N-methylimideformamide.

(2) Inhibitors of the respiratory chain in Complex I or Complex II, such as (2.001) benzobindiflupill, (2.002) bixaphen, (2.003) boscalide, (2.004) carboxyne. , (2.005) fluopirum, (2.006) flutranil, (2.007) fluxapyroxado, (2.08) flametopyl, (2.009) isofetamide, (2.010) isopyrazam (anti-epimeric). Enantiomer 1R, 4S, 9S), (2.011) isopyrazam (anti-epimeric enantiomer 1S, 4R, 9R), (2.012) isopyrazam (anti-epimeric racemic compound 1RS, 4SR, 9SR), (2. 013) isopyrazam (mixture of syn-epimeric racemic compounds (1RS, 4SR, 9RS) and anti-epimeric racemic compounds (1RS, 4SR, 9SR)), (2.014) isopyrazam (thin-epimeric enantiomer 1R, 4S) , 9R), (2.015) isopyrazam (syn-epimeric enantiomer 1S, 4R, 9S), (2.016) isopyrazam (syn-epimeric racemic compound 1RS, 4SR, 9RS), (2.017) penflufen, (2.018) Penthiopyrado, (2.019) Pydiflumetofen, (2.020) Pyraziflumid, (2.021) Sedaxan, (2.022) 1,3-dimethyl-N- (1, 1,3-trimethyl-2,3-dihydro-1H-inden-4-yl) -1H-pyrazol-4-carboxamide, (2.023) 1,3-dimethyl-N-[(3R) -1,1 , 3-trimethyl-2,3-dihydro-1H-inden-4-yl] -1H-pyrazol-4-carboxamide, (2.024) 1,3-dimethyl-N-[(3S) -1,1, 3-trimethyl-2,3-dihydro-1H-inden-4-yl] -1H-pyrazol-4-carboxamide, (2.025) 1-methyl-3- (trifluoromethyl) -N- [2'- (Trifluoromethyl) biphenyl-2-yl] -1H-pyrazol-4-carboxamide, (2.026) 2-fluoro-6- (trifluoromethyl) -N- (1,1,3-trimethyl-2, 3-Dihydro-1H-inden-4-yl) benzamide, (2.027) 3- (difluoromethyl) -1-methyl-N- (1,1,3-trimethyl-2,3-di) Hydro-1H-inden-4-yl) -1H-pyrazole-4-carboxamide, (2.028) 3- (difluoromethyl) -1-methyl-N-[(3R) -1,1,3-trimethyl- 2,3-Dihydro-1H-inden-4-yl] -1H-pyrazol-4-carboxamide, (2.029) 3- (difluoromethyl) -1-methyl-N-[(3S) -1,1, 3-trimethyl-2,3-dihydro-1H-inden-4-yl] -1H-pyrazol-4-carboxamide, (2.030) 3- (difluoromethyl) -N- (7-fluoro-1,1, 3-trimethyl-2,3-dihydro-1H-inden-4-yl) -1-methyl-1H-pyrazol-4-carboxamide, (2.031) 3- (difluoromethyl) -N-[(3R)- 7-Fluoro-1,1,3-trimethyl-2,3-dihydro-1H-inden-4-yl] -1-methyl-1H-pyrazol-4-carboxamide, (2.032) 3- (difluoromethyl) -N-[(3S) -7-fluoro-1,1,3-trimethyl-2,3-dihydro-1H-inden-4-yl] -1-methyl-1H-pyrazole-4-carboxamide, (2. 033) 5,8-Difluoro-N- [2- (2-fluoro-4-{[4- (trifluoromethyl) pyridine-2-yl] oxy} phenyl) ethyl] quinazoline-4-amine, (2. 034) N- (2-cyclopentyl-5-fluorobenzyl) -N-cyclopropyl-3- (difluoromethyl) -5-fluoro-1-methyl-1H-pyrazole-4-carboxamide, (2.035) N- (2-tert-Butyl-5-methylbenzyl) -N-cyclopropyl-3- (difluoromethyl) -5-fluoro-1-methyl-1H-pyrazol-4-carboxamide, (2.036) N- (2) -Tert-Butylbenzyl) -N-cyclopropyl-3- (difluoromethyl) -5-fluoro-1-methyl-1H-pyrazole-4-carboxamide, (2.037) N- (5-chloro-2-ethyl) Benzyl) -N-cyclopropyl-3- (difluoromethyl) -5-fluoro-1-methyl-1H-pyrazol-4-carboxamide, (2.038) N- (5-chloro-2-isopropylbenzyl) -N -Cyclopropyl-3- (difluoromethyl) -5-fluoro-1-methyl-1H-pyrazole-4-carboxamide, (2. 039) N-[(1R, 4S) -9- (dichloromethylene) -1,2,3,4-tetrahydro-1,4-methanonaphthalene-5-yl] -3- (difluoromethyl) -1-methyl -1H-pyrazole-4-carboxamide, (2.040) N-[(1S, 4R) -9- (dichloromethylene) -1,2,3,4-tetrahydro-1,4-methanonaphthalene-5-yl ] -3- (Difluoromethyl) -1-methyl-1H-pyrazole-4-carboxamide, (2.041) N- [1- (2,4-dichlorophenyl) -1-methoxypropan-2-yl] -3 -(Difluoromethyl) -1-methyl-1H-pyrazole-4-carboxamide, (2.042) N- [2-chloro-6- (trifluoromethyl) benzyl] -N-cyclopropyl-3- (difluoromethyl) )-5-Fluoro-1-methyl-1H-pyrazole-4-carboxamide, (2.043) N- [3-chloro-2-fluoro-6- (trifluoromethyl) benzyl] -N-cyclopropyl-3 -(Difluoromethyl) -5-fluoro-1-methyl-1H-pyrazole-4-carboxamide, (2.044) N- [5-chloro-2- (trifluoromethyl) benzyl] -N-cyclopropyl-3 -(Difluoromethyl) -5-fluoro-1-methyl-1H-pyrazole-4-carboxamide, (2.045) N-cyclopropyl-3- (difluoromethyl) -5-fluoro-1-methyl-N-[ 5-Methyl-2- (trifluoromethyl) benzyl] -1H-pyrazol-4-carboxamide, (2.046) N-cyclopropyl-3- (difluoromethyl) -5-fluoro-N- (2-fluoro-) 6-Isopropylbenzyl) -1-methyl-1H-pyrazol-4-carboxamide, (2.047) N-cyclopropyl-3- (difluoromethyl) -5-fluoro-N- (2-isopropyl-5-methylbenzyl) ) -1-Methyl-1H-pyrazole-4-carboxamide, (2.048) N-cyclopropyl-3- (difluoromethyl) -5-fluoro-N- (2-isopropylbenzyl) -1-methyl-1H- Pyrazole-4-carbothioamide, (2.049) N-cyclopropyl-3- (difluoromethyl) -5-fluoro-N- (2-isopropylbenzyl) -1-methyl-1H-pyrazol-4-carboxamide, ( 2.050) N-cyclopropyl-3 -(Difluoromethyl) -5-fluoro-N- (5-fluoro-2-isopropylbenzyl) -1-methyl-1H-pyrazole-4-carboxamide, (2.051) N-cyclopropyl-3- (difluoromethyl) ) -N- (2-Ethyl-4,5-dimethylbenzyl) -5-fluoro-1-methyl-1H-pyrazol-4-carboxamide, (2.052) N-cyclopropyl-3- (difluoromethyl)- N- (2-ethyl-5-fluorobenzyl) -5-fluoro-1-methyl-1H-pyrazol-4-carboxamide, (2.053) N-cyclopropyl-3- (difluoromethyl) -N- (2) -Ethyl-5-methylbenzyl) -5-fluoro-1-methyl-1H-pyrazole-4-carboxamide, (2.054) N-cyclopropyl-N- (2-cyclopropyl-5-fluorobenzyl) -3 -(Difluoromethyl) -5-fluoro-1-methyl-1H-pyrazole-4-carboxamide, (2.055) N-cyclopropyl-N- (2-cyclopropyl-5-methylbenzyl) -3- (difluoro) Methyl) -5-fluoro-1-methyl-1H-pyrazole-4-carboxamide, (2.056) N-cyclopropyl-N- (2-cyclopropylbenzyl) -3- (difluoromethyl) -5-fluoro- 1-Methyl-1H-pyrazole-4-carboxamide.

(3) Respiratory chain inhibitors in Complex III, such as (3.001) amethoctrazine, (3.002) amysulbrom, (3.003) azoxystrobin, (3.004) coumethothrobin. ), (3.005) spumoxystrobin, (3.006) siazofamide, (3.007) dymoxystrobin, (3.08) enoxastrobin, (3.009) famoxadon, (3.010). Fenamiden, (3.011) fluphenoxystrobin, (3.012) fluoxastrobin, (3.013) cresoxime-methyl, (3.014) metminostrobin, (3.015) orisastrobin , (3.016) picoxystrobin, (3.017) pyracrostrobin, (3.018) pyrametostrobin, (3.019) pyraoxystrobin, (3.020) trifloxystrobin, ( 3.021) (2E) -2-{2-[({[(1E) -1-(3-{[(E) -1-fluoro-2-phenylvinyl] oxy} phenyl) ethylidene] amino} oxy ) Methyl] phenyl} -2- (methoxyimino) -N-methylacetamide, (3.022) (2E, 3Z) -5-{[1- (4-chlorophenyl) -1H-pyrazol-3-yl] oxy } -2- (methoxyimino) -N,3-dimethylpenta-3-enamide, (3.023) (2R) -2- {2-[(2,5-dimethylphenoxy) methyl] phenyl} -2- Methyl-N-methylacetamide, (3.024) (2S) -2-{2-[(2,5-dimethylphenoxy) methyl] phenyl} -2-methoxy-N-methylacetamide, (3.025) ( 3S, 6S, 7R, 8R) -8-benzyl-3-[({3-[(isobutyryloxy) methoxy] -4-methoxypyridine-2-yl} carbonyl) amino] -6-methyl-4, 9-Dioxo-1,5-dioxonan-7-yl 2-methylpropanoate, (3.026) 2-{2-[(2,5-dimethylphenoxy) methyl] phenyl} -2-methoxy-N- Methylacetamide, (3.027) N- (3-ethyl-3,5,5-trimethylcyclohexyl) -3-formamide-2-hydroxybenzamide, (3.028) (2E, 3Z) -5-{[1 -(4-Chloro-2-fluorophenyl) -1H-pyrazole-3-yl] omega} -2- (methoxyimino) -N, 3-dimethylpenta-3-enamide.

(4) Inhibitors of thread division and cell division, such as (4.001) carbendazim, (4.002) dietofencarb, (4.003) etaboxam, (4.004) fluoricolide, (4.005) pencyclon. , (4.006) thiabendazole, (4.007) thiophanate-methyl, (4.08) zoxamide, (4.009) 3-chloro-4- (2,6-difluorophenyl) -6-methyl-5- Phenylpyridazine, (4.010) 3-chloro-5- (4-chlorophenyl) -4- (2,6-difluorophenyl) -6-methylpyridazine, (4.011) 3-chloro-5- (6-- Chloropyridine-3-yl) -6-methyl-4- (2,4,6-trifluorophenyl) pyridazine, (4.012) 4- (2-bromo-4-fluorophenyl) -N- (2, 6-Difluorophenyl) -1,3-dimethyl-1H-pyrazole-5-amine, (4.013) 4- (2-bromo-4-fluorophenyl) -N- (2-bromo-6-fluorophenyl) -1,3-dimethyl-1H-pyrazole-5-amine, (4.014) 4- (2-bromo-4-fluorophenyl) -N- (2-bromophenyl) -1,3-dimethyl-1H- Pyrazol-5-amine, (4.015) 4- (2-bromo-4-fluorophenyl) -N- (2-chloro-6-fluorophenyl) -1,3-dimethyl-1H-pyrazole-5-amine , (4.016) 4- (2-bromo-4-fluorophenyl) -N- (2-chlorophenyl) -1,3-dimethyl-1H-pyrazole-5-amine, (4.017) 4- (2) -Bromo-4-fluorophenyl) -N- (2-fluorophenyl) -1,3-dimethyl-1H-pyrazole-5-amine, (4.018) 4- (2-chloro-4-fluorophenyl)- N- (2,6-difluorophenyl) -1,3-dimethyl-1H-pyrazole-5-amine, (4.019) 4- (2-chloro-4-fluorophenyl) -N- (2-chloro- 6-Fluorophenyl) -1,3-dimethyl-1H-pyrazole-5-amine, (4.020) 4- (2-chloro-4-fluorophenyl) -N- (2-chlorophenyl) -1,3- Dimethyl-1H-pyrazole-5-amine, (4.021) 4- (2-chloro-4-fluorophenyl) -N- (2-fluorophenyl) -1,3-dimethyl-1H-pyrazole- 5-amine, (4.022) 4- (4-chlorophenyl) -5- (2,6-difluorophenyl) -3,6-dimethylpyridazine, (4.023) N- (2-bromo-6-fluoro) Phenyl) -4- (2-chloro-4-fluorophenyl) -1,3-dimethyl-1H-pyrazole-5-amine, (4.024) N- (2-bromophenyl) -4- (2-chloro -4-Fluorophenyl) -1,3-dimethyl-1H-pyrazole-5-amine, (4.025) N- (4-chloro-2,6-difluorophenyl) -4- (2-chloro-4-) Fluorophenyl) -1,3-dimethyl-1H-pyrazole-5-amine.

(5) Compounds capable of exhibiting activity at multiple sites, such as (5.001) Bordeaux solution, (5.002) captahole, (5.003) captan, (5.004) chlorothalonil, (5.005). Copper hydroxide, (5.006) copper naphthenate, (5.007) copper oxide, (5.08) basic copper chloride, (5.009) copper sulphate (2+), (5.010) dithianone, ( 5.011) Copper, (5.012) Holpet, (5.013) Manzeb, (5.014) Manneb, (5.015) Methylam, (5.016) Methylam zinc (zinc metiram), (5.017) ) Copper oxine, (5.018) propineb, (5.019) sulfur and sulfur agents such as calcium polysulfide, (5.020) thiuram, (5.021) zinc, (5.022). Zinc.

(6) Compounds capable of inducing host defense, such as (6.001) acibenzolar-S-methyl, (6.02) isothianyl, (6.003) probenazole, (6.004) thiazinyl.

(7) Inhibitors of amino acid and / or protein biosynthesis, such as (7.001) cyprodinyl, (7.002) kasugamycin, (7.003) kasugamycin hydrochloride hydrate, (7.004) oxytetracycline, (7.005) pyrimethanyl, (7.06) 3- (5-fluoro-3,3,4,5-tetramethyl-3,4-dihydroisoquinoline-1-yl) quinoline.

(8) ATP production inhibitor, for example, (8.01) silthiofham.

(9) Cell wall synthesis inhibitors, such as (9.001) Bench Avaricarb, (9.002) Dimethmorph, (9.003) Fulmorph, (9.004) Iprovaricarb, (9.005) Mandipropamide, (9). .006) pyrimorph, (9.07) varifenalate, (9.08) (2E) -3- (4-tert-butylphenyl) -3- (2-chloropyridin-4-yl)- 1- (Morpholine-4-yl) propa-2-ene-1-one, (9.009) (2Z) -3- (4-tert-butylphenyl) -3- (2-chloropyridin-4-yl) ) -1- (Morpholine-4-yl) propa-2-en-1-one.

(10) Inhibitors of lipid and membrane synthesis, such as (10.001) propamocarb, (10.002) propamocarb hydrochloride, (10.03) turquophos-methyl.

(11) Melanin biosynthesis inhibitor, for example, (11.001) tricyclazole, (11.002) 2,2,2-trifluoroethyl {3-methyl-1-[(4-methylbenzoyl) amino] butane- 2-Il} carbamate.

(12) Nucleic acid synthesis inhibitors, such as (12.001) Benalaxil, (12.002) Benalaxil-M (Kiraluxil), (12.003) Metalaxil, (12.004) Metalaxil-M (Mephenoxam).

(13) Signal transduction inhibitors, such as (13.001) fludioxonyl, (13.002) iprodion, (13.003) procymidone, (13.004) proquinazide, (13.005) quinoxyphen, (13.006). Bincrozoline.

(14) Compounds that can act as deconjugating agents, such as (14.001) fluazinum, (14.002) meptyldinocup.

(15) Additional compounds such as (15.001) absidic acid, (15.002) benzazole, (15.003) betoxazine, (15.004) capsimycin, (15.005) carboxylic, (15). .006) quinomethionate, (15.007) phenyleneb, (15.008) siflufenamide, (15.009) simoxanyl, (15.010) cyprosulfamide, (15.011) fluthianyl, (15.012) Josetil- Aluminum, (15.013) Josetyl-calcium, (15.014) Josetil-sodium, (15.015) Methyl isothiocyanate, (15.016) Metraphenone, (15.017) Mildiomycin, (15.018) Natamicin, (15.019) nickel dimethyldithiocarbamate, (15.020) nitrotal-isopropyl, (15.021) oxamocarb, (15.022) oxathiapiproline, (15.023) oxyphenthine (15.023) Oxyphenylin, (15.024) pentachlorophenol and salt, (15.025) phosphonic acid and its salts, (15.026) propamocarb-phosphate, (15.027) pyriophenylone (chlazafenone). ), (15.028) Tebuflokin, (15.029) Tecrophthalam, (15.030) Tornifanide, (15.031) 1- (4- {4-[(5R) -5- (2,6-difluorophenyl)) ) -4,5-dihydro-1,2-oxazole-3-yl] -1,3-thiazole-2-yl} piperidine-1-yl) -2- [5-methyl-3- (trifluoromethyl) -1H-pyrazole-1-yl] etanone, (15.032) 1-(4- {4-[(5S) -5- (2,6-difluorophenyl) -4,5-dihydro-1,2- Oxazole-3-yl] -1,3-thiazole-2-yl} piperidine-1-yl) -2- [5-methyl-3- (trifluoromethyl) -1H-pyrazol-1-yl] etanone, ( 15.033) 2- (6-benzylpyridine-2-yl) quinazoline, (15.034) 2,6-dimethyl-1H, 5H- [1,4] dithino [2,3-c: 5,6-- c'] Zipylol-1,3,5,7 (2H, 6H) -Tetron , (15.035) 2- [3,5-bis (difluoromethyl) -1H-pyrazole-1-yl] -1- [4- (4- {5- [2- (propa-2-in-1) -Iloxy) phenyl] -4,5-dihydro-1,2-oxazole-3-yl} -1,3-thiazole-2-yl) piperidin-1-yl] etanone, (15.036) 2- [3 , 5-Bis (difluoromethyl) -1H-pyrazole-1-yl] -1- [4- (4- {5- [2-chloro-6- (propa-2-in-1-yloxy) phenyl]- 4,5-Dihydro-1,2-oxazol-3-yl} -1,3-thiazole-2-yl) piperidin-1-yl] etanone, (15.037) 2- [3,5-bis (difluoro) Methyl) -1H-pyrazole-1-yl] -1- [4- (4- {5- [2-fluoro-6- (propa-2-in-1-yloxy) phenyl] -4,5-dihydro- 1,2-Oxazole-3-yl} -1,3-thiazole-2-yl) piperidin-1-yl] etanone, (15.038) 2- [6- (3-fluoro-4-methoxyphenyl)- 5-Methylpyridin-2-yl] quinazoline, (15.039) 2-{(5R) -3- [2- (1-{[3,5-bis (difluoromethyl) -1H-pyrazole-1-yl] ] Acetyl} piperidine-4-yl) -1,3-thiazole-4-yl] -4,5-dihydro-1,2-oxazol-5-yl} -3-chlorophenyl methanesulfonate, (15.040) 2 -{(5S) -3- [2- (1-{[3,5-bis (difluoromethyl) -1H-pyrazole-1-yl] acetyl} piperidine-4-yl) -1,3-thiazole-4 -Il] -4,5-dihydro-1,2-oxazol-5-yl} -3-chlorophenyl methanesulfonate, (15.041) 2- {2-[(7,8-difluoro-2-methylquinolin-) 3-yl) oxy] -6-fluorophenyl} propan-2-ol, (15.042) 2- {2-fluoro-6-[(8-fluoro-2-methylquinolin-3-yl) oxy] phenyl } Propane-2-ol, (15.043) 2- {3- [2-(1-{[3,5-bis (difluoromethyl) -1H-pyrazole-1-yl] acetyl} piperidine-4-yl] ) -1,3-Thiazole-4-yl] -4,5-dihydro-1,2-oxazol-5-yl} -3-clo Lophenyl methanesulfonate, (15.044) 2- {3- [2-(1-{[3,5-bis (difluoromethyl) -1H-pyrazol-1-yl] acetyl} piperidine-4-yl) -1 , 3-Thiazole-4-yl] -4,5-dihydro-1,2-oxazole-5-yl} phenyl methanesulfonate, (15.045) 2-phenylphenol and its salts, (15.046) 3- (4,5,5-trifluoro-3,3-dimethyl-3,4-dihydroisoquinolin-1-yl) quinoline, (15.047) 3- (4,4-difluoro-3,3-dimethyl-3) , 4-Dihydroisoquinolin-1-yl) quinoline, (15.048) 4-amino-5-fluoropyrimidine-2-ol (mutual morphology: 4-amino-5-fluoropyrimidine-2 (1H) -one) ), (15.049) 4-oxo-4-[(2-phenylethyl) amino] butyric acid, (15.050) 5-amino-1,3,4-thiasizole-2-thiol, (15.051). 5-Chloro-N'-phenyl-N'-(propa-2-in-1-yl) thiophene 2-sulfonohydrazide, (15.052) 5-fluoro-2-[(4-fluorobenzyl) oxy] Pyrimidin-4-amine, (15.053) 5-fluoro-2-[(4-methylbenzyl) oxy] pyrimidin-4-amine, (15.054) 9-fluoro-2,2-dimethyl-5-( Quinoline-3-yl) -2,3-dihydro-1,4-benzoxazepine, (15.055) Buta-3-in-1-yl {6-[({[(Z)-(1-) Methyl-1H-tetrazol-5-yl) (phenyl) methylene] amino} oxy) methyl] pyridine-2-yl} carbamate, (15.056) (2Z) -3-amino-2-cyano-3-phenylacrylic Ethyl acid acid, (15.557) phenazine-1-carboxylic acid, (15.058) propyl 3,4,5-trihydroxybenzoate, (15.059) quinoline-8-ol, (15.060) quinoline- 8-allsulfate (2: 1), (15.061) {6-[({[(1-methyl-1H-tetrazol-5-yl) (phenyl) methylene] amino} oxy) methyl] pyridine-2 -Il} tert-butyl carbamate.

Microbial agents, beneficial organisms include, in particular, bacteria, fungi, yeasts, plant extracts and products formed by microorganisms (eg, proteins and secondary metabolites).

Bacteria include, for example, spore-forming bacteria, bacteria that colonize roots and bacteria that act as biological insecticides, fungicides or nematodes.

Examples of the above bacteria are:
Bacillus amyloliquefaciens strain FZB42 (DSM 231179), or Bacillus cereus, especially Bacillus cereus strain CNCM I-1562, or Bacillus film. Bacillus filmus strain I-1582 (trust number CNCM I-1582), or Bacillus plumils, in particular stock GB34 (trust number ATCC 700814) and stock QST2808 (trust number NRRL B-3807), or Bacillus subtilis, in particular strain GB03 (accession number ATCC SD-1397) or Bacillus subtilis strain QST713 (accession number NRRL B-21661) or Bacillus subtilis Strain OST 30002 (accession number NRRL B-50421), Bacillus turingiensis, in particular Bacillus turingiensis subspecies Islaelensis (B. turingiensis subspecies sraelensis type 65) antigen -52 (accession number ATCC 1276) or Bacillus turingiensis subspecies Isawai (B. turingiensis subsp. Aizawai), in particular the strain ABTS-1857 (SD-1372) or Bacillus turgingiensis subspecies Kurstaki (B. turingiensis subsp. Kurstaki) strain HD-1, or Bacillus turgingiensis subspecies Tenebrionis (B. turingiensis subsp. Tenebrionis) strain NB 176 (SD-5428), Bacillus tera penesura penes. Species (Pasteria spp.) (Rotylenchurus reniformis nematode) -PR3 (accession number ATCC SD-5834), Streptomyces microflabus AQ6 (= QRD 31.013, NRRL B-50550), Streptomyces galbus strain AQ 6047 (accession number NRRL 30232).

Examples of fungi and yeasts are:
Beauveria bassiana, especially ATCC 74040, Coniothirium minitans, especially CON / M / 91-8 (accession number DSM-9660), Lecanicillium species (Leclic) , Strain HRO LEC 12, Lecanicillium lecanii (formerly known as Verticillium lecanii), in particular KV01, in particular Strain KV01, Metallidium anisopriae (Metaridium anisopriae) / ATCC 90448), Metoscanicovia fructicola, especially NRRL Y-30752, Paesiromyces fumosoroseus (Paecilomyces fumosoroseus) (New: Isaophila) 97 (accession number ATCC 20874), Paecilomyces lilacinus, in particular P. lilacinus strain 251 (AGAL 89/030550), Talaromyces trichoderma, especially Talaromyces trichoderma, Trichoderma harzianum, in particular, strain SC1 (accession number CBS 122089), Trichoderma harzianum, in particular Trichoderma harzianum refine (T. harzianum rifi) (T. harzianum rifi).

Examples of viruses are:
Ringworm (Adoxophyes orana) Granular disease virus (GV), Codling moth (Cydia pomonella) Granular disease virus (GV), Helicoverpa armyworm (Helicoverpa armigara) Nuclear polygonal disease virus (NPV), Beet armyworm (NPV) Fall armyworm (Spodoptera frugiperda) mNPV, Egyptian cotton leafworm (African cotton leafworm) (Spodoptera littoralis) NPV.

Bacteria and fungi that are added as "sources of inoculation" to a plant or part of a plant or organ of a plant and whose particular properties promote plant growth and plant health are also included. Examples include:
Agrobacterium spp., Azorizobium caulinodans, Azospiryllum spp., Azotoburkholderia spp. Burkholderia spp. Burkholderia spp. Burkholderia spp. Species (Burkholderia spp.), In particular Burkholderia sepasia (formerly known as Pseudomonas cepasia), Gigaspora genus (Gigaspora sp. monosporum, glomus spp., Laccaria spp., Lactobacillus buchneri, paraglomus spp., Pisolithus spp., Pisoritus spp. Pseudomonas spp.), Burkholderia spp., In particular, Burkholderia trifolia, Burkholderia spp., Burkholderia spp., Burkholderia spp., Burkholderia spp. , Streptomyces spp.

Examples of plant extracts and products formed by microorganisms, which include proteins and secondary metabolites, are:
Carrot (Allium sativum), Nigayomogi (Artemisia absinthium), Azajirachtin, Biokeeper WP, Cassia niglicans (Cassia nigricans), Serastolus anglatus Male fern (Dryopteris filix-mas), Sugina (Equisetum arvense), Fortune Aza, Fungastop, Heads Up (Chenopodium quinoa, Saponina, Saponin extract) Quercus, Quillaja, Regalia, ("Requiem ^TM Authentide"), Rotenon, Liania / Ryanozin, Symphytum officinale, Yomogi (Tanacetum tubicine), Yomogi (Tanacetum ul) Urtica dioica, Veratrin, Viscum album, Brassicaceae extract, especially rapeseed powder or Karashina powder.

Preferred examples of smectite minerals according to the present invention include montmorillonite, biderite, nontronite, saponite, hectorite, saponite and steepunsite. Bentonite containing montmorillonite as a main component is also included in the smectite mineral according to the present invention. Bentonite is suitable as the smectite mineral according to the present invention.

Examples of the alkylnaphthalene sulfonic acid derivative according to the present invention include sodium sodium salt of sodium sodium sulfonate sulfonic acid formalin and sodium salt of formalin sulfonic acid alkylnaphthalene sulfonic acid, and sodium salt of formalin sulfonic acid alkylnaphthalene sulfonic acid is preferable.

The content ratio of the alkylnaphthalene sulfonic acid derivative in the pesticide granule composition of the present invention is preferably 0.1 to 2.0% by weight, more preferably 0.15 to 0.75% by weight. More preferably, it is 0.2 to 0.6% by weight.

The content ratio of pregelatinized starch in the pesticide granule composition of the present invention is preferably 0.1 to 10% by weight, more preferably 0.2 to 5% by weight, and even more preferably 0. 5 to 3 weight percent.

The content ratio of smectite mineral in the pesticide granule composition of the present invention is preferably 1 to 50% by weight, more preferably 2 to 30% by weight, still more preferably 3 to 20% by weight. ..

The pesticide granule composition of the present invention further contains an auxiliary agent such as a bulking agent, a water-soluble binder, a surfactant, a solvent, a stabilizer, a granulation accelerator, a preservative, a colorant, a pH adjuster, and a fragrance. be able to.

Clay, calcium carbonate, silica sand and its crushed product, diatomaceous earth, talc, zirclite, sericite, acidic clay, activated clay, silicate, pumice, zeolite, vermiculite, white carbon, silas balloon, etc. were crushed as bulking agents. Inorganic carriers such as vitreous powder, water-insoluble organic carriers such as cellulose, pulp, fir, wood flour, starch, and soybean flour, and water-soluble solid carriers such as urea, lactose, sucrose, salt, jar, and citrate anhydride. Can be mentioned.

Examples of the water-soluble binder include sodium carboxymethyl cellulose, hydroxypropyl methyl cellulose, methyl cellulose, methyl ethyl cellulose, hydroxypropyl cellulose, sodium polyacrylate, traganth gum, polyvinylpyrrolidone, polyvinyl alcohol, dextrin, alginic acid and sodium alginate.

Examples of the surfactant include nonionic surfactants, anionic surfactants, cationic surfactants and double-sided surfactants.

For example, examples of the nonionic surfactant include polyoxyalkylene alkyl ether, polyoxyalkylene alkyl aryl ether, polyoxyalkylene allyl phenyl ether, polyoxyalkylene alkyl ester, polyoxyalkylene sorbitan alkylate, and polyoxyalkylene phenyl ether polymer. Examples thereof include polyoxyalkylene alkylene arylphenyl ether, polyoxyalkylene alkylene glycol, and polyoxyethylene polyoxypropylene block polymer.

Examples of anionic surfactants include lignin sulfonate, alkylaryl sulfonate, dialkyl sulfosuccinate, polyoxyalkylene alkylaryl ether sulfate salt, alkylnaphthalene sulfonate, polyoxyalkylene allylphenyl ether sulfate salt, and lauryl sulfate. Examples include salt.

Examples of the cationic surfactant include an alkyltrimethylammonium salt, an alkyldimethylbenzylammonium salt, and an alkylpyridinium salt.

Examples of the amphoteric tenside include dialkyldiaminoethyl betaine and alkyldimethylbenzyl betaine. However, the surfactant that can be used in the present invention is not limited to these examples, and there is no problem even if one kind or two or more kinds are used in combination.

pH regulators include citric acid, malic acid, phosphoric acid, sodium citrate, potassium citrate, magnesium oxide, sodium carbonate, sodium hydrogen carbonate, disodium hydrogen phosphate, dipotassium hydrogen phosphate, trisodium phosphate, Examples thereof include potassium pyrophosphate or sodium pyrophosphate, water-containing substances thereof, anhydrous crystals, and the like. However, the pH adjuster that can be used in the present invention is not limited to these examples, and there is no problem even if one kind or two or more kinds are used in combination.

The pesticide granule composition of the present invention can be produced by a production method known per se. For example, pesticide active ingredients, smectite minerals, preservative starch, alkylnaphthalene sulfonic acid derivatives, and, if necessary, bulking agents, water-soluble binders, surfactants, solvents, stabilizers, pH adjusters, granulation accelerators. A desired pesticide granule can be prepared by granulating by a method such as a coating method or a kneading method together with an auxiliary agent such as a preservative, a coloring agent, and a fragrance.

In the case of coated granules, the pesticide active ingredient, smectite mineral, pregelatinized starch, and alkylnaphthalene sulfonic acid derivative may be contained in the coating layer or may be impregnated in the water-absorbent granules.

When producing a coated granule, for example, a mixed solution of water and a surfactant is added to the granule core and mixed, and the resulting mixture is a pesticide active ingredient, smectite mineral, pregelatinized starch, alkylnaphthalene sulfonic acid derivative, etc. In addition, a desired pesticide granule can be produced by adding the above-mentioned auxiliary agent, mixing and pulverizing, coating the prepared bulk powder, and then drying, if necessary, crushing, sieving, sizing, and the like.

In the coated granules, examples of the granule nuclei include calcium carbonate components such as limestone and marble, silica sand, pumice stone, clay granules, and granulated inorganic substance granules.

On the other hand, in the case of producing kneaded granules, the pesticide active ingredient, smectite mineral, pregelatinized starch, alkylnaphthalene sulfonic acid derivative, and other above-mentioned auxiliaries are mixed together, and water is added to mix or knead well. , Granulation, the obtained granulated product is dried, and if necessary, crushing, sieving, sizing, etc. can be performed to produce a desired pesticide granule.

A kneading machine is used for the kneading. Examples of the kneader include a universal mixer, a kneader, a ladyge mixer, a vertical granulator and the like.

The amount of water used during kneading is usually 5 to 20 parts by weight with respect to 100 parts by weight of the mixture.

When producing the kneaded granules, it is usually carried out using a screen having a size of 0.3 to 1.8 mmφ, preferably 0.8 to 1.2 mmφ.

The granulators used include screw type extrusion granulators, roll type extrusion granulation machines, disc peretter type extrusion granulation machines, pellet mill type extrusion granulation machines, basket type extrusion granulation machines, and plaid type extrusion granulation machines. Examples thereof include granulation machines, oscillating type extrusion granulation machines, gear type extrusion granulation machines, ring die type extrusion granulation machines, and specifically, Multigran MG-55-2; DALTON CORPORATION can be used.

The obtained granulated product is usually dried at 50 to 120 ° C, preferably 60 to 80 ° C.

The pesticide granule composition of the present invention can be applied at any time from before sowing to the same time as transplantation.

For application before sowing, for example, a method in which a mixture of a pesticide granule composition and bed soil is added to a nursery box and then seeds are sown.

Examples of application at the time of sowing include a method of spraying a solid pesticide composition after sowing seeds and before covering soil.

For application at the time of transplanting, for example, a method of spraying a pesticide granule composition on a seedling raising box from a few days before transplanting a seedling to a paddy field or a field, a method of transplanting a seedling with a rice transplanter, etc. Examples include a method of spraying.

The pesticide granule composition of the present invention can be applied to a nursery box by any method. For example, in addition to mixing with the floor soil described above, a sprayer can also be used.

Examples of the nursery box that can be used in the method of the present invention include a nursery box for rice, a cell tray for horticultural crops (vegetables, fruit trees, flowers), and a plastic container.

When the solid pesticide composition is applied to the rice seedling raising box by the method of the present invention, the application rate is usually 10 to 200 g, preferably 50 to 100 g per seedling raising box. In the case of applying a plastic container such as a seedling raising box 448 holes (manufactured by Minoru Industry Co., Ltd.) dedicated to the Minoru pot system, the weight is usually 33 to 66 g (1 to 2 kg per 10a) per container.

The pesticide granule composition applied to the rice seedling box of the present invention can be obtained by a granulation method usually used in the formulation of pesticides. For example, pesticide active ingredients, alkylnaphthalene sulfonic acid derivatives, pregelatinized starch, smectite minerals, surfactants, water-soluble binders, solvents, auxiliary agents, bulking agents, etc. are added as necessary, and vertical granulators (Co., Ltd.) After mixing and crushing with Paulec's trade name), it is squeezed with water, granulated using an extrusion granulator, dried in a fluidized bed dryer, and sized to prepare. Alternatively, the powder mixture may be granulated with a rolling granulator while adding water to the powder mixture, dried and sized, or the powder mixture may be fluidized by spraying a binder, an aqueous solution or an active ingredient. It can also be produced by a fluidized bed granulator that granulates.

Further, the dosage form that the rice seedling box application granules of the present invention can take is not limited as long as it is a solid preparation other than powder such as granules, granules, and tablets.

Next, the present invention will be described in more detail with reference to Production Examples, Examples, Comparative Examples and Test Examples, but the present invention is not limited thereto.

Among the substances used in this example, those that require special explanation are shown below.

Isothianyl is a known compound and can be produced, for example, by the method described in WO 99/024413.

Penfluphen is a known compound and can be produced, for example, by the method described in International Publication No. 2003/010149 Pamphlet.

Tetraniliprol is a known compound and can be produced, for example, by the method described in WO 2011/157664.

Examples of the alkylnaphthalene sulfonic acid derivative include MorwetD425 (manufactured by AkzoNobel), TERSPERSE2020 (manufactured by Huntsman), and Agrosurf WG-2300 (manufactured by Takemoto Oil & Fat Co., Ltd.).

Examples of the alpha-formed starch include Amikol HF, Amikor C, Amikol KF, Amikor HG-N, Amikol BJ-2, Amikol W, Starch MH-A, Amikol A, Amikol FW (manufactured by Nihon Shogaku Co., Ltd.) Ulster, Nissho Ulster H, Nissho Waxi α (manufactured by Nihon Shokuhin Kako Co., Ltd.), Corn αY, Corn αS-1, Industrial Tapioca α, Industrial Tapioca αTP-2, Wheat Starch αWA-105 (Sanwa Cornstarch Co., Ltd.) (Made by Co., Ltd.), Amilox No. 1. Amilox No. 1A (manufactured by Japan Corn Starch Co., Ltd.) and the like can be mentioned.

Preferred examples of smectite minerals include bentonite Fuji, bentonite Hotaka, bentonite Akagi, bentonite Myogi, Super Clay (manufactured by Hojun Co., Ltd.), Knigel V1, Knigel V2, Knigel VA, and Kunibond (Kunimine Industrial Co., Ltd.). Bentonite such as (manufactured by the company) and Kansai bentonite (manufactured by Kanesan Kogyo Co., Ltd.) can be mentioned.

The amounts of solid components listed in Table 1 are mixed using a universal mixing stirrer (5DM-L-03-r; DALTON CORPORATION), and the liquid soluble components are added thereto in the optimum amount of water (relative to the mixture). It is solubilized in 13.5%), added, mixed and kneaded for 2 minutes, and then extruded from a screen with an opening diameter of 1.0 mm using a granulator (Multigran MG-55-2; manufactured by DALTON CORPORATION). The granulated product was granulated and the granulated product was dried at 80 ° C. by a dryer (FD-LAB-1; manufactured by POWEREX CORPORATION). Finally, sieving was performed with a sieve having a mesh size of 1.4 mm and 0.5 mm to obtain a pesticide granule composition of the present invention and a pesticide granule composition of Comparative Example.

Growth test for rice by pre-soil covering at the time of sowing of paddy rice Using a small paddy rice seedling box (about 1/12 the size of a normal seedling raising box 30 cm x 60 cm), 8 test granule compositions were applied before soil covering at the time of sowing. It was treated at a ratio of .3 g / nursery box, and 12.5 g of dried paddy (variety: Koshihikari) was sown. After germination in a seedling raising device (28 ° C. all day) for 66 hours, seedlings were raised on a hotbed mat (20 ° C.) in a vinyl house. After raising seedlings for 21 days, the rooting strength of rice (treated plot) was measured. The growth rate (%) was calculated by comparing the root tension strength of the treated group with the root tension strength of the untreated group by Equation 1, and the growth condition was evaluated according to the following criteria.

<< Criteria for growth status >>

From the results of the growth test on rice, it was demonstrated that the pesticide granule composition of the present invention has an excellent phytotoxicity reducing effect.

Claims (6)

1. A pesticide granule composition for rice seedling box application, which contains a pesticide active ingredient, an alkylnaphthalene sulfonic acid derivative, pregelatinized starch, and smectite minerals.
2. The pesticide granule composition according to claim 1, wherein the content ratio of the pesticide active ingredient is 1 to 30% by weight.
3. The pesticide granule composition according to claim 1 or 2, wherein the content ratio of the alkylnaphthalene sulfonic acid derivative is 0.1 to 2.0% by weight.
4. The pesticide granule composition according to any one of claims 1 to 3, wherein the content ratio of pregelatinized starch is 0.1 to 10% by weight.
5. The pesticide granule composition according to any one of claims 1 to 4, wherein the smectite mineral is bentonite.
6. The pesticide granule composition according to any one of claims 1 to 5, wherein the content ratio of smectite mineral is 1 to 50% by weight.