KR20220127904A - Agrochemical granular composition for rice seedling box application with reduced damage - Google Patents

Abstract

[Problem] The present invention provides an agrochemical granular composition for application in a rice seedling box with reduced damage.
[Solutions] The composition is an agrochemical granular composition for rice seedling box application, characterized in that it contains an agrochemical active ingredient, an alkylnaphthalenesulfonic acid derivative, pregelatinized starch, and a smectite mineral.

Description

Agrochemical granular composition for rice seedling box application with reduced damage

The present invention relates to an agricultural chemical granular composition for rice seedling box application with reduced damage and a method for producing the same.

When using an agrochemical, it is preferable to reduce the usage-amount or frequency of use of an agrochemical from a viewpoint of energy saving and reduction of environmental load. In response to such a request, in transplantation water cultivation, the pesticide used in the paddy field is applied to the seedling box, and the seedling box treatment in which the effect is exhibited in the paddy field after transplantation is performed. However, when seedlings are treated with ordinary granular pesticides, there are cases in which weak damage such as growth retardation or poor growth of seedlings may be caused by the leached or released pesticide active ingredient or other ingredients. For this reason, development of the seedling box treatment agent which prevents or reduces the damage to the weak seedling of a seedling period is calculated|required.

Until now, there have been reported pesticide formulations for the purpose of suppressing the elution of the agrochemical active ingredient and reducing the damage caused by the contact between the seedlings in the seedling box and the agrochemical active ingredient (Patent Documents 1, 2, 3). In methods other than dissolution control, an agrochemical formulation for the purpose of reducing the damage to seedlings by addition of a specific substance has also been reported (Patent Document 4).

Patent Document 1: Japanese Patent Laid-Open No. 2012-111752 Patent Document 2: Japanese Patent Publication No. 2012-508713 Patent Document 3: Japanese Patent Laid-Open No. 2012-17271 Patent Document 4: Japanese Patent Laid-Open No. 2009-221108

An object of the present invention is to provide an agrochemical preparation composition having an excellent weakening effect against an agrochemical active ingredient having a high risk of poor growth of rice seedlings.

The present inventors found that an agricultural chemical granular composition for rice seedling box application containing an agrochemical active ingredient, an alkylnaphthalenesulfonic acid derivative, a pregelatinized starch, and a smectite mineral has an excellent weakening effect, and completed the present invention.

The present invention provides the following solutions.

[1] Agrochemical granular composition for rice seedling box application, characterized by containing an agrochemical active ingredient, an alkylnaphthalenesulfonic acid derivative, pregelatinized starch, and a smectite mineral.

[2] The agrochemical granular composition according to [1], wherein the content of the agrochemical active ingredient is 1 to 30% by weight.

[3] The agrochemical granular composition according to [1] or [2], wherein the content of the alkylnaphthalenesulfonic acid derivative is 0.1 to 2.0% by weight.

[4] The agrochemical granular composition according to any one of [1] to [3], wherein the content of pregelatinized starch is 0.1 to 10% by weight.

[5] The agrochemical granular composition according to any one of [1] to [4], wherein the smectite mineral is bentonite.

[6] The agrochemical granular composition according to any one of [1] to [5], wherein the smectite mineral content is 1 to 50% by weight.

When the agricultural chemical granular composition of this invention is applied to the rice seedling box, the weak damage caused by the component containing an agricultural chemical active ingredient can be reduced.

The present invention provides an agrochemical granular composition for rice seedling box application, comprising an agrochemical active ingredient, an alkylnaphthalenesulfonic acid derivative, a smectite mineral, and pregelatinized starch.

Agrochemical active ingredients according to the present invention are pesticides, acaricides, nematicides, fungicides, bactericides, molluscs control agents, microbes, beneficial organisms, lobster worms, herbicides, algae repellents, plant enhancers, sterilants, information chemicals and/or plant growth regulators.

Insecticide/Acaricide/Necticide

The active ingredient specified by "generic name" in this specification is known, and is described, for example, in ""The Pesticide Manual", 16th ed., British Crop Protection Council 2012, or can be searched on the Internet. (eg, "http://www.alanwood.net/pesticides"). Its classification is based on "IRAC Mode of Action Classification Scheme" applicable at the time of filing of this patent application.

(1) acetylcholinesterase (AChE) inhibitors, such as

carbamates such as alanikab, aldicarb, bendiocarb, benfuracarb, butocarboxyime, butoxycarboxyime, calvaril, carbofuran, carbosulfan, ethiophencarb, fenobucarb, fometa Nate, furatiocarb, isoprocarb, methiocarb, methomyl, metolcarb, oxamyl, pyrimicarb, propoxer, thiodicarb, thiophanox, triazamate, trimetacarb, XMC and xylyl carb; or

Organic phosphoric acid esters, such as acetate, azamethifos, azinephos-ethyl, azinephos-methyl, cadusaphos, chlorethoxyphos, chlorfenvinphos, chlormephos, chlorpyrifos-methyl, coumaphos, cia nophos, dimethone-S-methyl, diazinon, dichlorbose/DDVP, dicrotophos, dimethoate, dimethylvinphos, disulfotone, EPN, ethion, etoprophos, pamper, phenamiphos, Penitrothione, penthione, phostiazite, heptenophos, imiciaphos, isopenphos, O-(methoxyaminothiophosphoryl) isopropyl salicylate, isoxathione, malathione, mecarbam, metamido Phos, methidathione, mevinphos, monocrotophos, naled, ometoate, oxydimetone-methyl, parathion-methyl, pentoate, porate, phosalone, fosmet, phosphamidone, poxim, pyrimi phos-methyl, propenophos, proptamphos, prothiophos, pyraclophos, pyridapentione, quinalphos, sulfotep, tebupyrimphos, temephos, terbufos, tetrachlorvinphos, thiomethone, triazophos, trichlorphone and bamidothione.

(2) GABA control chloride channel blockers, such as

cyclodiene-organochlorine systems such as chlordan and endosulfan; or

phenylpyrazoles (fiprole), such as ethiprole and fipronil.

(3) sodium channel modulators, such as

pyrethroids, such as acrinathrin, allethrin, d-cis-trans allethrin, d-trans allethrin, bifenthrin, bioallethrin, bioallethrin, S-cyclopentenyl isomer, bioresmethrin, Cycloprotrin, cyfluthrin, beta-cyfluthrin, cyhalothrin, lambda-cyhalothrin, gamma-cyhalothrin, cypermethrin, alpha-cypermethrin, beta-cypermethrin Lin, theta-cypermethrin, zeta-cypermethrin, cyfenotrin [(1R)-trans isomer], deltamethrin, empenthrin [(EZ)-(1R) isomer], esfenvalerate , etofenprox, fenpropatrine, fenvalerate, flucithrinate, flumethrine, tau-fluvalinate, halfenprox, imiprotrin, cadetrin, monfluorotrin, permethrin, phenotrin Lin [(1R)-trans isomer], pralethrine, pyrethrins (pyrethrum), resmethrin, silafluorphen, tefluthrin, tetramethrin, tetramethrin [(1R) isomer], tralomethrin and transfluthrin; or

DDT; or methoxychlor.

(4) nicotinic acetylcholine receptor (nAChR) competitive modulators, such as

neonicotinoids such as acetamiprid, clothianidine, dinotefuran, imidacloprid, nitenpyram, thiacloprid and thiamethoxam; or

nicotine; or

sulfoxaflor or flupyradifuron.

(5) nicotinic acetylcholine receptor (nAChR) allosteric modulators, such as

Spinosyns such as spinetoram and spinosad.

(6) Glutamic Acid Control Chloride Channel (GluCl) allosteric modulators, such as

avermectins/milbemycins such as abamectin, emamectin benzoate, lepimectin and milbemectin.

(7) juvenile hormone mimicking substances, such as

juvenile hormone analogues such as hydroprene, quinoprene and metprene; or

phenoxycarb; or pyriproxyfen.

(8) various unspecified (multi-site) inhibitors, such as

halogenated alkyl systems such as methyl bromide and separate alkyl halides; or

chloropicrin; or sulfuryl fluoride; or borax; or earth tin; or

methyl isocyanate generating substances such as diazomet and metam.

(9) string organ modulators, such as

pymetrozine; or flonicamide.

(10) tick growth inhibitors, such as

clopentezine, hexythiazox and diflovidazine; or

ethoxazole.

(11) a microbial disruptor of the insect midsera, such as

Bacillus thuringiensis subspecies israelensis, Bacillus sphaericus, Bacillus thuringiensis subspecies aizawai, Bacillus thuringiensis subspecies israelensis, Bacillus thuringiensis subspecies aizawai, Bacillus thuringiensis subspecies kurstaki , Bacillus thuringiensis subspecies tenebrionis and Bt plant proteins: Cry1Ab, Cry1Ac, Cry1Fa, Cry1A.105, Cry2Ab, Vip3A, mCry3A, Cry3Ab, Cry3Bb, Cry3Bb1/35A

(12) inhibitors of mitochondrial ATP synthase, such as ATP, such as

diafenthiuron; or

organotin compounds such as azocyclotin, cyhexatin and phenbutatin oxide; or

propazite; or tetradiphone.

(13) deconjugation agents of oxidative phosphorylation by disrupting the proton gradient, such as

Chlorfenapyr, DNOC and sulfuramide.

(14) nicotinic acetylcholine receptor channel blockers, such as

Bensultap, Cartap Hydrochloride, Thiocyclam and Thiosultap-Sodium.

(15) inhibitors of chitin biosynthesis (type 0), such as

Bistrifluron, chlorfluazuron, diflubenzuron, flucycloxuron, flufenoxuron, hexaflumuron, lufenuron, novaluron, nobiflumuron, teflubenzuron and triflumuron.

(16) inhibitors of chitin biosynthesis (type 1), such as

bupropezin.

(17) Moulting disruptors (especially in the case of bipolar trees), such as

Syromazine.

(18) ecdysone receptor agonists, such as

Chromafenozide, halofenozide, methoxyfenozide and tebufenozide.

(19) octopamine receptor agonists, such as

Amitraz.

(20) mitochondrial complex III electron transport inhibitors, such as

hydramethylnon; or acequinosyl; or fluacrypyrim.

(21) mitochondrial complex I electron transport inhibitors, such as

METI acaricides such as fenazaquin, fenpyroximate, pyrimidifen, pyridaben, tebufenpyrad and tolfenpyrad; or

rotenone (Derris).

(22) potential dependent sodium channel blockers, such as

indoxacarb; or metaflumizone.

(23) inhibitors of acetyl CoA carboxylase, such as

tetoronic acid derivatives and tetramic acid derivatives such as spirodiclofen, spiromesifen and spirotetramat.

(24) mitochondrial complex IV electron transport inhibitors, such as

phosphine-based, such as aluminum phosphide, calcium phosphide, phosphine and zinc phosphide; or

cyanide, calcium cyanide, potassium cyanide and sodium cyanide.

(25) mitochondrial complex II electron transport inhibitors, such as

β-ketonitrile derivatives such as cyenopyrafen and ciflfumethophen and carboxanilides such as fiflubumide.

(28) ryanodine receptor modulators, such as

diamides such as chlorantranilprole, cyanthranilprole, flubendiamide, tetraniliprole and tetrachlorantraniliprole.

additional active ingredients such as apidopyrrofen, apoxolaner, azadiractin, inpirfluxam, benzlotiaz, benzoximate, bifenazate, broflanilide, bromopropylate, Chinomethionate, chloroprallethrin, cryolite, cyclaniliprol, cycloxaprid, cyhalodiamide, dichloromezotiaz, dicopol, ε -Metofluthrin, epsilon momfluthrin, flumetoquine, fluazaindolizine, fluenesulfone, fluphenerim, fluphenoxystrobin, flufiprole, flu hexafon, fluopyram, fluralaner, fluxametamide, fufenozide, guadipyr, heptafluthrin, imidaclotiz, iprodione, κ-bifenthrin, κ- Tefluthrin, lotilaner, meperfluthrin, paichongding, pyridalyl, pyrifluquinazone, pyriminostrobin, spirobudiclofen, tetramethylflutrin, thioxazafen , thiofluoximate, triflumesopyrim and iodomethane; Add to

Preparations based on Bacillus firmus (I-1582, BioNeem, Votivo) and the following compounds:

1-{2-Fluoro-4-methyl-5-[(2,2,2-trifluoroethyl)sulfinyl]phenyl}-3-(trifluoromethyl)-1H-1,2,4- Triazol-5-amine (known from WO 2006/043635 A) (CAS 885026-50-6), {1'-[(2E)-3-(4-chlorophenyl)prop-2-ene- 1-yl]-5-fluorospiro[indole-3,4'-piperidin]-1(2H)-yl}(2-chloropyridin-4-yl)methanone (known from WO 2003/106457 A ) (CAS 637360-23-7), 2-chloro-N-[2-{1-[(2E)-3-(4-chlorophenyl)prop-2-en-1-yl]piperi Din-4-yl}-4-(trifluoromethyl)phenyl]isonicotinamide (known from WO 2006/003494 A) (CAS 872999-66-1), 3-(4-chloro-2,6 -dimethylphenyl)-4-hydroxy-8-methoxy-1,8-diazaspiro[4.5]dec-3-en-2-one (known from WO 2010/052161 A) (CAS 1225292-17 -0), 3-(4-chloro-2,6-dimethylphenyl)-8-methoxy-2-oxo-1,8-diazaspiro[4.5]dec-3-en-4-yl ethyl carbonate ( known from EP 2647626 B) (CAS-1440516-42-6), 4-(but-2-yn-1-yloxy)-6-(3,5-dimethylpiperidin-1-yl)- 5-fluoropyrimidine (known from WO 2004/099160 A) (CAS 792914-58-0), PF1364 (known from JP 2010/018586 A) (CAS Reg. No. 1204776-60-2) , N-[(2E)-1-[(6-chloropyridin-3-yl)methyl]pyridin-2(1H)-ylidene]-2,2,2-trifluoroacetamide (WO 2012/029672 known from A) (CAS 1363400-41-2), (3E)-3-[1-[(6-chloro-3-pyridyl)methyl]-2-pyridylidene]-1,1,1 -trifluoropropan-2-one (known from WO 2013/144213 A) (CAS 1461743-15-6), N-[3-(benzylcarbamoyl)-4-chlorophenyl]-1-methyl -3-(Pentafluoroethyl)-4-(trifluoromethyl) tyl)-1H-pyrazole-5-carboxamide (known from WO 2010/051926 A) (CAS 1226889-14-0), 5-bromo-4-chloro-N-[4-chloro-2 -Methyl-6-(methylcarbamoyl)phenyl]-2-(3-chloro-2-pyridyl)pyrazole-3-carboxamide (known from CN 103232431 A) (CAS 1449220-44-3 ), 4- [5- (3,5-dichlorophenyl) -4,5-dihydro-5- (trifluoromethyl) -3-isoxazolyl] -2-methyl-N- (cis-1- Oxide-3-thietanyl)benzamide, 4-[5-(3,5-dichlorophenyl)-4,5-dihydro-5-(trifluoromethyl)-3-isoxazolyl]-2-methyl -N-(trans-1-oxide-3-thietanyl)benzamide and 4-[(5S)-5-(3,5-dichlorophenyl)-4,5-dihydro-5-(trifluoromethyl )-3-isoxazolyl]-2-methyl-N-(cis-1-oxide-3-thietanyl)benzamide (known from WO 2013/050317 A1) (CAS 1332628-83-7), N -[3-chloro-1-(3-pyridinyl)-1H-pyrazol-4-yl]-N-ethyl-3-[(3,3,3-trifluoropropyl)sulfinyl]propanamide; (+)-N-[3-chloro-1-(3-pyridinyl)-1H-pyrazol-4-yl]-N-ethyl-3-[(3,3,3-trifluoropropyl) alcohol Pynyl]propanamide and (-)-N-[3-chloro-1-(3-pyridinyl)-1H-pyrazol-4-yl]-N-ethyl-3-[(3,3,3-tri Fluoropropyl)sulfinyl]propanamide (known from WO 2013/162715 A2, WO 2013/162716 A2, US 2014/0213448 A1) (CAS 1477923-37-7), 5-[[(2E)-3 -Chloro-2-propen-1-yl]amino]-1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-4-[(trifluoromethyl)sulfinyl]-1H- Pyrazole-3-carbonitrile (known from CN 101337937 A) (CAS 1105672-77-2), 3-bromo-N-[4-chloro-2-methyl-6-[(methylamino)thioxo methyl]phenyl]-1-(3-chloro-2-pyridinyl)-1H-pyrazole-5-carboxamide (Liudaibenjiax uanan, known from CN 103109816 A) (CAS 1232543-85-9); N-[4-chloro-2-[[(1,1-dimethylethyl)amino]carbonyl]-6-methylphenyl]-1-(3-chloro-2-pyridinyl)-3-(fluoromethoxy) -1H-pyrazole-5-carboxamide (known from WO 2012/034403 A1) (CAS 1268277-22-0), N-[2-(5-amino-1,3,4-thiadiazole) -2-yl)-4-chloro-6-methylphenyl]-3-bromo-1-(3-chloro-2-pyridinyl)-1H-pyrazole-5-carboxamide from WO 2011/085575 A1 known) (CAS 1233882-22-8), 4-[3-[2,6-dichloro-4-[(3,3-dichloro-2-propen-1-yl)oxy]phenoxy]pro poxy]-2-methoxy-6-(trifluoromethyl)pyrimidine (as described from CN 101337940 A) (CAS 1108184-52-6); (2E)- and (2Z)-2-[2-(4-cyanophenyl)-1-[3-(trifluoromethyl)phenyl]ethylidene]-N-[4-(difluoromethoxy) phenyl]hydrazinecarboxamide (known from CN 101715774 A) (CAS 1232543-85-9); Cyclopropanecarboxylic acid 3-(2,2-dichloroethenyl)-2,2-dimethyl-4-(1H-benzimidazol-2-yl)phenyl ester (known from CN 103524422 A) (CAS 1542271 -46-4); (4aS)-7-chloro-2,5-dihydro-2-[[(methoxycarbonyl)[4-[(trifluoromethyl)thio]phenyl]amino]carbonyl]indeno[1,2 -e][1,3,4]oxadiazine-4a(3H)-carboxylic acid methyl ester (known from CN 102391261 A) (CAS 1370358-69-2); 6-deoxy-3-O-ethyl-2,4-di-O-methyl-1-[N-[4-[1-[4-(1,1,2,2,2-pentafluoroe oxy)phenyl]-1H-1,2,4-triazol-3-yl]phenyl]carbamate]-α-L-mannopyranose (known from US 2014/0275503 A1) (CAS 1181213-14 -8); 8-(2-cyclopropylmethoxy-4-trifluoromethylphenoxy)-3-(6-trifluoromethylpyridazin-3-yl)-3-azabicyclo[3.2.1]octane (CAS 1253850 -56-4), (8-anti)-8-(2-cyclopropylmethoxy-4-trifluoromethylphenoxy)-3-(6-trifluoromethylpyridazin-3-yl)-3 -azabicyclo[3.2.1]octane (CAS 933798-27-7), (8-sine)-8-(2-cyclopropylmethoxy-4-trifluoromethylphenoxy)-3-(6-tri Fluoromethylpyridazin-3-yl)-3-azabicyclo[3.2.1]octane (known from WO 2007/040280 A1, WO 2007/040282 A1) (CAS 934001-66-8) and N-[ 3-Chloro-1-(3-pyridinyl)-1H-pyrazol-4-yl]-N-ethyl-3-[(3,3,3-trifluoropropyl)thio]propanamide (WO 2015/ 058021 A1, known from WO 2015/058028 A1) (CAS 1477919-27-9).

disinfectant

The active ingredient specified by the "generic name" in the present specification is known, and, for example, it is described in the "Pesticide Manual" (16th Ed., British Crop Protection Council), or can be searched on the Internet ( For example, "http://www.alanwood.net/pesticides").

All of the components described in classes (1) to (15), based on their functional groups, can form salts with appropriate bases or acids, if possible, if appropriate. All of the disinfectant mixture components described in classes (1) to (15) may optionally contain tautomeric forms.

(1) inhibitors of ergosterol biosynthesis, such as (1.001) ciproconazole, (1.002) difenoconazole, (1.003) epoxyconazole, (1.004) fenhexamid, (1.005) fenpropidine, (1.006) fen Profimorph, (1.007) Fenpyrazamine, (1.008) Fluquinconazole, (1.009) Flutriafol, (1.010) Imazalil, (1.011) Imazalyl sulfate, (1.012) Ifconazole, (1.013) Met Conazole, (1.014) Microbutanil, (1.015) Paclobutrazole, (1.016) Prochloraz, (1.017) Propiconazole, (1.018) Prothioconazole, (1.019) Pyrisoxazole, (1.020) ) spiroxamine, (1.021) tebuconazole, (1.022) tetraconazole, (1.023) triadimenol, (1.024) tridemorph, (1.025) triticonazole, (1.026) (1R,2S,5S) )-5-(4-chlorobenzyl)-2-(chloromethyl)-2-methyl-1-(1H-1,2,4-triazol-1-ylmethyl)cyclopentanol, (1.027) (1S ,2R,5R)-5-(4-chlorobenzyl)-2-(chloromethyl)-2-methyl-1-(1H-1,2,4-triazol-1-ylmethyl)cyclopentanol, ( 1.028) (2R)-2-(1-chlorocyclopropyl)-4-[(1R)-2,2-dichlorocyclopropyl]-1-(1H-1,2,4-triazol-1-yl) Butan-2-ol, (1.029) (2R)-2-(1-chlorocyclopropyl)-4-[(1S)-2,2-dichlorocyclopropyl]-1-(1H-1,2,4- Triazol-1-yl)butan-2-ol, (1.030) (2R)-2-[4-(4-chlorophenoxy)-2-(trifluoromethyl)phenyl]-1-(1H-1 ,2,4-triazol-1-yl)propan-2-ol, (1.031) (2S)-2-(1-chlorocyclopropyl)-4-[(1R)-2,2-dichlorocyclopropyl] -1-(1H-1,2,4-triazol-1-yl)butan-2-ol, (1.032) (2S)-2-(1-chlorocyclopropyl)-4-[(1S)-2 ,2-Dichlorocyclopropyl]-1-(1H-1,2,4-triazol-1-yl)butan-2-ol, (1.033) (2S)-2-[4-(4-chlorophene) Noxy)-2-(trifluoromethyl)phenyl]-1-(1H-1,2,4-triazol-1-yl)propan-2-ol, (1.034) (R)-[3-(4) -Chloro-2-fluorophenyl)-5-(2,4-difluorophenyl)-1,2-oxazol-4-yl](pyridin-3-yl)methanol, (1.035) (S)- [3- (4-chloro-2-fluorophenyl) -5- (2,4-difluorophenyl) -1,2-oxazol-4-yl] (pyridin-3-yl) methanol, (1.036 ) [3- (4-chloro-2-fluorophenyl) -5- (2,4-difluorophenyl) -1,2-oxazol-4-yl] (pyridin-3-yl) methanol, ( 1.037) 1-({(2R,4S)-2-[2-chloro-4-(4-chlorophenoxy)phenyl]-4-methyl-1,3-dioxolan-2-yl}methyl)-1H -1,2,4-triazole, (1.038) 1-({(2S,4S)-2-[2-chloro-4-(4-chlorophenoxy)phenyl]-4-methyl-1,3- Dioxolan-2-yl}methyl)-1H-1,2,4-triazole, (1.039) 1-{[3-(2-chlorophenyl)-2-(2,4-difluorophenyl)oxy Ran-2-yl]methyl}-1H-1,2,4-triazol-5-ylthiocyanate, (1.040) 1-{[rel(2R,3R)-3-(2-chlorophenyl)- 2-(2,4-difluorophenyl)oxiran-2-yl]methyl}-1H-1,2,4-triazol-5-ylthiocyanate, (1.041) 1-{[rel(2R) ,3S)-3-(2-chlorophenyl)-2-(2,4-difluorophenyl)oxiran-2-yl]methyl}-1H-1,2,4-triazol-5-ylthio Cyanate, (1.042) 2-[(2R,4R,5R)-1-(2,4-dichlorophenyl)-5-hydroxy-2,6,6-trimethylheptan-4-yl]-2,4 -dihydro-3H-1,2,4-triazole-3-thione, (1.043) 2-[(2R,4R,5S)-1-(2,4-dichlorophenyl)-5-hydroxy-2 ,6,6-trimethylheptan-4-yl]-2,4-dihydro-3H-1,2,4-triazole-3-thione, (1.044) 2-[(2R,4S,5R)-1 -(2,4-dichlorophenyl)-5-hydroxy-2,6,6-trimethylheptan-4-yl]-2,4-dihydro-3H-1,2,4-triazole-3-thione , (1.045) 2-[(2R,4S,5S)-1-(2,4-dichlorophenyl)-5-hydroxy Cy-2,6,6-trimethylheptan-4-yl]-2,4-dihydro-3H-1,2,4-triazole-3-thione, (1.046) 2-[(2S,4R,5R )-1-(2,4-dichlorophenyl)-5-hydroxy-2,6,6-trimethylheptan-4-yl]-2,4-dihydro-3H-1,2,4-triazole- 3-Thion, (1.047) 2-[(2S,4R,5S)-1-(2,4-dichlorophenyl)-5-hydroxy-2,6,6-trimethylheptan-4-yl]-2, 4-dihydro-3H-1,2,4-triazole-3-thione, (1.048) 2-[(2S,4S,5R)-1-(2,4-dichlorophenyl)-5-hydroxy- 2,6,6-trimethylheptan-4-yl]-2,4-dihydro-3H-1,2,4-triazole-3-thione, (1.049) 2-[(2S,4S,5S)- 1-(2,4-dichlorophenyl)-5-hydroxy-2,6,6-trimethylheptan-4-yl]-2,4-dihydro-3H-1,2,4-triazole-3- Thione, (1.050) 2-[1-(2,4-dichlorophenyl)-5-hydroxy-2,6,6-trimethylheptan-4-yl]-2,4-dihydro-3H-1,2 ,4-triazole-3-thione, (1.051) 2- [2-chloro-4- (2,4-dichlorophenoxy) phenyl] -1- (1H-1,2,4-triazole-1- yl) propan-2-ol, (1.052) 2- [2-chloro-4- (4-chlorophenoxy) phenyl] -1- (1H-1,2,4-triazol-1-yl) butane- 2-ol, (1.053) 2-[4-(4-chlorophenoxy)-2-(trifluoromethyl)phenyl]-1-(1H-1,2,4-triazol-1-yl)butane -2-ol, (1.054) 2- [4- (4-chlorophenoxy) -2- (trifluoromethyl) phenyl] -1- (1H-1,2,4-triazol-1-yl) Pentan-2-ol, (1.055) 2- [4- (4-chlorophenoxy) -2- (trifluoromethyl) phenyl] -1- (1H-1,2,4-triazol-1-yl ) propan-2-ol, (1.056) 2-{[3-(2-chlorophenyl)-2-(2,4-difluorophenyl)oxiran-2-yl]methyl}-2,4-di Hydro-3H-1,2,4-triazole-3-thione, (1.057) 2-{[rel(2R,3R)-3-(2-chlorophenyl)-2-(2,4-difluoro phenyl)oxiran-2-yl]methyl}-2,4-dihydro-3H-1,2,4-triazole-3-thione; (1.058) 2-{[rel(2R,3S)-3-(2-chlorophenyl)-2-(2,4-difluorophenyl)oxiran-2-yl]methyl}-2,4-di Hydro-3H-1,2,4-triazole-3-thione, (1.059) 5- (4-chlorobenzyl) -2- (chloromethyl) -2-methyl-1- (1H-1,2,4 -Triazol-1-ylmethyl)cyclopentanol, (1.060) 5-(allylsulfanyl)-1-{[3-(2-chlorophenyl)-2-(2,4-difluorophenyl)oxy Ran-2-yl]methyl}-1H-1,2,4-triazole, (1.061) 5-(allylsulfanyl)-1-{[rel(2R,3R)-3-(2-chlorophenyl) -2-(2,4-difluorophenyl)oxiran-2-yl]methyl}-1H-1,2,4-triazole, (1.062) 5-(allylsulfanyl)-1-{[rel (2R,3S)-3-(2-chlorophenyl)-2-(2,4-difluorophenyl)oxiran-2-yl]methyl}-1H-1,2,4-triazole, (1.063 ) N'-(2,5-dimethyl-4-{[3-(1,1,2,2-tetrafluoroethoxy)phenyl]sulfanyl}phenyl)-N-ethyl-N-methylimideform Amide, (1.064) N'-(2,5-dimethyl-4-{[3-(2,2,2-trifluoroethoxy)phenyl]sulfanyl}phenyl)-N-ethyl-N-methyl is Midformamide, (1.065) N'-(2,5-dimethyl-4-{[3-(2,2,3,3-tetrafluoropropoxy)phenyl]sulfanyl}phenyl)-N-ethyl- N-methylimideformamide, (1.066) N'-(2,5-dimethyl-4-{[3-(pentafluoroethoxy)phenyl]sulfanyl}phenyl)-N-ethyl-N-methyl is Midformamide, (1.067) N'-(2,5-dimethyl-4-{3-[(1,1,2,2-tetrafluoroethyl)sulfanyl]phenoxy}phenyl)-N-ethyl- N-methylimideformamide, (1.068) N'-(2,5-dimethyl-4-{3-[(2,2,2-trifluoroethyl)sulfanyl]phenoxy}phenyl)-N- Ethyl-N-methylimideformamide, (1.069) N'-(2,5-dimethyl-4-{3-[(2,2,3,3-tetrafluoropropyl)sulfanyl]phenoxy}phenyl )-N-ethyl-N-methylimideformamide, (1.070) N'-(2,5-dimethyl-4-{3-[(pentafluoroethyl)sulfanyl]phenoxy}phenyl)-N- Ethyl-N-methylimideformamide, (1.071) N'-(2,5-dimethyl-4-phenoxyphenyl)-N-ethyl-N-methylimideformamide, (1.072) N'-(4-{[3-(difluoromethoxy)phenyl] Sulfanyl}-2,5-dimethylphenyl)-N-ethyl-N-methylimideformamide, (1.073) N'-(4-{3-[(difluoromethyl)sulfanyl]phenoxy}- 2,5-Dimethylphenyl)-N-ethyl-N-methylimideformamide, (1.074) N'-[5-bromo-6-(2,3-dihydro-1H-inden-2-yloxy) )-2-methylpyridin-3-yl]-N-ethyl-N-methylimideformamide, (1.075) N'-{4-[(4,5-dichloro-1,3-thiazole-2- yl)oxy]-2,5-dimethylphenyl}-N-ethyl-N-methylimideformamide, (1.076) N'-{5-bromo-6-[(1R)-1-(3,5) -difluorophenyl)ethoxy]-2-methylpyridin-3-yl}-N-ethyl-N-methylimideformamide, (1.077) N'-{5-bromo-6-[(1S) -1-(3,5-difluorophenyl)ethoxy]-2-methylpyridin-3-yl}-N-ethyl-N-methylimideformamide, (1.078) N′-{5-bromo -6-[(cis-4-isopropylcyclohexyl)oxy]-2-methylpyridin-3-yl}-N-ethyl-N-methylimideformamide, (1.079) N'-{5-bromo -6-[(trans-4-isopropylcyclohexyl)oxy]-2-methylpyridin-3-yl}-N-ethyl-N-methylimideformamide, (1.080) N'-{5-bromo -6-[1-(3,5-difluorophenyl)ethoxy]-2-methylpyridin-3-yl}-N-ethyl-N-methylimideformamide.

(2) inhibitors of the respiratory chain in complex I or complex II, such as (2.001) benzovindiflupyr, (2.002) bixafen, (2.003) boscalid, (2.004) carboxycin, (2.005) fluopyram, (2.006) flutolanil, (2.007) floxapyroxad, (2.008) furametpyr, (2.009) isopetamide, (2.010) isopyrazam (anti-epimeric enantiomer 1R,4S,9S), (2.011) isopyrazam (anti-epimeric enantiomer 1S,4R,9R), (2.012) isopyrazam (anti-epimeric racemic compound 1RS,4SR,9SR), (2.013) isopyrazam (sine) -A mixture of an epimeric racemic compound (1RS,4SR,9RS) and an anti-epimeric racemic compound (1RS,4SR,9SR), (2.014) isopyrazam (syn-epimeric enantiomer 1R,4S, 9R), (2.015) isopyrazam (neo-epimeric enantiomer 1S,4R,9S), (2.016) isopyrazam (neo-epimeric racemic compound 1RS,4SR,9RS), (2.017) fenflu fen, (2.018) penthiopyrad, (2.019) pydiflumetofen, (2.020) pyraziflumide, (2.021) cedaxane, (2.022) 1,3-dimethyl-N- (1,1, 3-trimethyl-2,3-dihydro-1H-inden-4-yl)-1H-pyrazole-4-carboxamide, (2.023) 1,3-dimethyl-N-[(3R)-1,1 ,3-trimethyl-2,3-dihydro-1H-inden-4-yl]-1H-pyrazole-4-carboxamide, (2.024) 1,3-dimethyl-N-[(3S)-1, 1,3-trimethyl-2,3-dihydro-1H-inden-4-yl]-1H-pyrazole-4-carboxamide, (2.025) 1-methyl-3-(trifluoromethyl)-N -[2'-(trifluoromethyl)biphenyl-2-yl]-1H-pyrazole-4-carboxamide, (2.026) 2-fluoro-6-(trifluoromethyl)-N-( 1,1,3-trimethyl-2,3-dihydro-1H-inden-4-yl)benzamide, (2.027) 3-(difluoromethyl)-1-methyl-N-(1,1,3 -trimethyl-2,3-dihydro-1H-inden-4-yl)-1H -Pyrazole-4-carboxamide, (2.028) 3-(difluoromethyl)-1-methyl-N-[(3R)-1,1,3-trimethyl-2,3-dihydro-1H- inden-4-yl]-1H-pyrazole-4-carboxamide, (2.029) 3-(difluoromethyl)-1-methyl-N-[(3S)-1,1,3-trimethyl-2 ,3-dihydro-1H-inden-4-yl]-1H-pyrazole-4-carboxamide, (2.030) 3-(difluoromethyl)-N-(7-fluoro-1,1, 3-trimethyl-2,3-dihydro-1H-inden-4-yl)-1-methyl-1H-pyrazole-4-carboxamide, (2.031) 3-(difluoromethyl)-N-[ (3R)-7-fluoro-1,1,3-trimethyl-2,3-dihydro-1H-inden-4-yl]-1-methyl-1H-pyrazole-4-carboxamide, (2.032 ) 3-(difluoromethyl)-N-[(3S)-7-fluoro-1,1,3-trimethyl-2,3-dihydro-1H-inden-4-yl]-1-methyl- 1H-Pyrazole-4-carboxamide, (2.033) 5,8-difluoro-N-[2-(2-fluoro-4-{[4-(trifluoromethyl)pyridin-2-yl) ]oxy}phenyl)ethyl]quinazolin-4-amine, (2.034) N-(2-cyclopentyl-5-fluorobenzyl)-N-cyclopropyl-3-(difluoromethyl)-5-fluoro -1-methyl-1H-pyrazole-4-carboxamide, (2.035) N-(2-tert-butyl-5-methylbenzyl)-N-cyclopropyl-3-(difluoromethyl)-5- Fluoro-1-methyl-1H-pyrazole-4-carboxamide, (2.036) N-(2-tert-butylbenzyl)-N-cyclopropyl-3-(difluoromethyl)-5-fluoro -1-methyl-1H-pyrazole-4-carboxamide, (2.037) N-(5-chloro-2-ethylbenzyl)-N-cyclopropyl-3-(difluoromethyl)-5-fluoro -1-methyl-1H-pyrazole-4-carboxamide, (2.038) N-(5-chloro-2-isopropylbenzyl)-N-cyclopropyl-3-(difluoromethyl)-5-fluoro Rho-1-methyl-1H-pyrazole-4-carboxamide, (2.039) N-[(1R,4S)-9-(dichloromethylene)-1,2,3,4-tetrahydro-1,4 -methanonaphthalen-5-yl]-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide, (2.040) N-[(1S,4R)-9-(dichloromethylene)-1,2,3,4-tetrahydro-1,4-methanonaphthalen-5-yl]-3-(difluoromethyl)-1 -Methyl-1H-pyrazole-4-carboxamide, (2.041) N-[1-(2,4-dichlorophenyl)-1-methoxypropan-2-yl]-3-(difluoromethyl) -1-methyl-1H-pyrazole-4-carboxamide, (2.042) N-[2-chloro-6-(trifluoromethyl)benzyl]-N-cyclopropyl-3-(difluoromethyl) -5-Fluoro-1-methyl-1H-pyrazole-4-carboxamide, (2.043) N-[3-chloro-2-fluoro-6-(trifluoromethyl)benzyl]-N-cyclo Propyl-3-(difluoromethyl)-5-fluoro-1-methyl-1H-pyrazole-4-carboxamide, (2.044) N-[5-chloro-2-(trifluoromethyl)benzyl ]-N-Cyclopropyl-3-(difluoromethyl)-5-fluoro-1-methyl-1H-pyrazole-4-carboxamide, (2.045) N-cyclopropyl-3-(difluoro Methyl)-5-fluoro-1-methyl-N-[5-methyl-2-(trifluoromethyl)benzyl]-1H-pyrazole-4-carboxamide, (2.046) N-cyclopropyl-3 -(difluoromethyl)-5-fluoro-N-(2-fluoro-6-isopropylbenzyl)-1-methyl-1H-pyrazole-4-carboxamide, (2.047) N-cyclopropyl -3-(difluoromethyl)-5-fluoro-N-(2-isopropyl-5-methylbenzyl)-1-methyl-1H-pyrazole-4-carboxamide, (2.048) N-cyclo Propyl-3-(difluoromethyl)-5-fluoro-N-(2-isopropylbenzyl)-1-methyl-1H-pyrazole-4-carbothioamide, (2.049) N-cyclopropyl- 3-(Difluoromethyl)-5-fluoro-N-(2-isopropylbenzyl)-1-methyl-1H-pyrazole-4-carboxamide, (2.050) N-cyclopropyl-3-( Difluoromethyl)-5-fluoro-N-(5-fluoro-2-isopropylbenzyl)-1-methyl-1H-pyrazole-4-carboxamide, (2.051) N-cyclopropyl-3 -(difluoromethyl)-N-(2-ethyl-4,5-dimethylbenzyl)-5-fluoro-1-methyl-1H-pyrazole-4-carboxamide, (2.052) N-cyclopropyl -3-(difluoromethyl)-N-(2-ethyl-5-pl Luorobenzyl)-5-fluoro-1-methyl-1H-pyrazole-4-carboxamide, (2.053) N-cyclopropyl-3-(difluoromethyl)-N-(2-ethyl-5) -Methylbenzyl)-5-fluoro-1-methyl-1H-pyrazole-4-carboxamide, (2.054) N-cyclopropyl-N-(2-cyclopropyl-5-fluorobenzyl)-3- (difluoromethyl)-5-fluoro-1-methyl-1H-pyrazole-4-carboxamide, (2.055) N-cyclopropyl-N-(2-cyclopropyl-5-methylbenzyl)-3 -(difluoromethyl)-5-fluoro-1-methyl-1H-pyrazole-4-carboxamide, (2.056) N-cyclopropyl-N-(2-cyclopropylbenzyl)-3-(di Fluoromethyl)-5-fluoro-1-methyl-1H-pyrazole-4-carboxamide.

(3) Respiratory chain inhibitors in Complex III, such as (3.001) amethotradine, (3.002) amisulbrom, (3.003) azoxystrobin, (3.004) coumethoxystrobin, (3.005) ) coumoxystrobin, (3.006) cyazofamide, (3.007) dimoxystrobin, (3.008) enoxastrobin, (3.009) famoxadone, (3.010) phenamidone, (3.011) flufenoxystrobin ), (3.012) fluoxastrobin, (3.013) cresoxime-methyl, (3.014) metomynostrobin, (3.015) orissastrobin, (3.016) picoxastrobin, (3.017) pyraclostrobin, (3.018) ) pyrametostrobin, (3.019) pyraoxystrobin, (3.020) trifloxistrobin, (3.021) (2E)-2-{2-[({[(1E)-1-(3-{[( E)-1-fluoro-2-phenylvinyl]oxy}phenyl)ethylidene]amino}oxy)methyl]phenyl}-2-(methoxyimino)-N-methylacetamide, (3.022) (2E,3Z )-5-{[1-(4-chlorophenyl)-1H-pyrazol-3-yl]oxy}-2-(methoxyimino)-N,3-dimethylpent-3-enamide, (3.023) (2R)-2-{2-[(2,5-dimethylphenoxy)methyl]phenyl}-2-methoxy-N-methylacetamide, (3.024) (2S)-2-{2-[(2) ,5-Dimethylphenoxy)methyl]phenyl}-2-methoxy-N-methylacetamide, (3.025) (3S,6S,7R,8R)-8-benzyl-3-[({3-[(iso Butyryloxy)methoxy]-4-methoxypyridin-2-yl}carbonyl)amino]-6-methyl-4,9-dioxo-1,5-dioxonan-7-yl 2-methylpro Panoate, (3.026) 2-{2-[(2,5-dimethylphenoxy)methyl]phenyl}-2-methoxy-N-methylacetamide, (3.027) N-(3-ethyl-3,5 ,5-Trimethylcyclohexyl)-3-formamide-2-hydroxybenzamide, (3.028) (2E,3Z)-5-{[1-(4-chloro-2-fluorophenyl)-1H-pyra zol-3-yl]oxy}-2-(methoxyimino)-N,3-dimethylpent-3-enamide.

(4) inhibitors of mitosis and cell division, such as (4.001) carbendazim, (4.002) dietofencarb, (4.003) ethaboxam, (4.004) fluopicolide, (4.005) fencicuron, (4.006) Thiabendazole, (4.007) thiophanate-methyl, (4.008) zoxamide, (4.009) 3-chloro-4- (2,6-difluorophenyl) -6-methyl-5-phenylpyridazine, ( 4.010) 3-chloro-5- (4-chlorophenyl) -4- (2,6-difluorophenyl) -6-methylpyridazine, (4.011) 3-chloro-5- (6-chloropyridine-3 -yl)-6-methyl-4- (2,4,6-trifluorophenyl) pyridazine, (4.012) 4- (2-bromo-4-fluorophenyl) -N- (2,6- Difluorophenyl)-1,3-dimethyl-1H-pyrazol-5-amine, (4.013) 4-(2-bromo-4-fluorophenyl)-N-(2-bromo-6-fluoro Rophenyl)-1,3-dimethyl-1H-pyrazol-5-amine, (4.014) 4-(2-bromo-4-fluorophenyl)-N-(2-bromophenyl)-1,3 -Dimethyl-1H-pyrazol-5-amine, (4.015) 4-(2-bromo-4-fluorophenyl)-N-(2-chloro-6-fluorophenyl)-1,3-dimethyl- 1H-Pyrazol-5-amine, (4.016) 4-(2-bromo-4-fluorophenyl)-N-(2-chlorophenyl)-1,3-dimethyl-1H-pyrazol-5-amine , (4.017) 4- (2-bromo-4-fluorophenyl) -N- (2-fluorophenyl) -1,3-dimethyl-1H-pyrazol-5-amine, (4.018) 4- ( 2-Chloro-4-fluorophenyl)-N-(2,6-difluorophenyl)-1,3-dimethyl-1H-pyrazol-5-amine, (4.019) 4-(2-chloro-4 -Fluorophenyl) -N- (2-chloro-6-fluorophenyl) -1,3-dimethyl-1H-pyrazol-5-amine, (4.020) 4- (2-chloro-4-fluorophenyl) ) -N- (2-chlorophenyl) -1,3-dimethyl-1H-pyrazol-5-amine, (4.021) 4- (2-chloro-4-fluorophenyl) -N- (2-fluoro Phenyl)-1,3-dimethyl-1H-pyrazol-5-amine, (4.022) 4-(4-chlorophenyl)-5-(2,6-difluorophenyl)-3,6-dimethylpyridazine , (4.023) N-( 2-Bromo-6-fluorophenyl)-4-(2-chloro-4-fluorophenyl)-1,3-dimethyl-1H-pyrazol-5-amine, (4.024) N-(2-bro mophenyl)-4-(2-chloro-4-fluorophenyl)-1,3-dimethyl-1H-pyrazol-5-amine, (4.025) N-(4-chloro-2,6-difluoro Phenyl)-4-(2-chloro-4-fluorophenyl)-1,3-dimethyl-1H-pyrazol-5-amine.

(5) compounds capable of exhibiting multisite activity, such as (5.001) Bordeaux solution, (5.002) Captapol, (5.003) Captan, (5.004) Chlorthalonil, (5.005) Copper hydroxide, (5.006) Naph Copper Thenate, (5.007) Copper Oxide, (5.008) Basic Copper Chloride, (5.009) Copper Sulfate (2+), (5.010) Dithianone, (5.011) Dodyne, (5.012) Folpet, (5.013) Manzeb, ( 5.014) manneb, (5.015) methiram, (5.016) zinc metiram, (5.017) copper oxine, (5.018) propineb, (5.019) sulfur and sulfur agent, such as calcium polysulfide, (5.020) thiuram, (5.021) zineb, (5.022) ziram.

(6) Compounds capable of inducing host defense, such as (6.001) acibenzoral-S-methyl, (6.002) isotianil, (6.003) probenazole, (6.004) thiadinyl.

(7) inhibitors of amino acid and/or protein biosynthesis, such as (7.001) cyprodinil, (7.002) kasugamycin, (7.003) kasugamycin hydrochloride hydrate, (7.004) oxytetracycline, (7.005) pyrimethanil , (7.006) 3-(5-Fluoro-3,3,4,4-tetramethyl-3,4-dihydroisoquinolin-1-yl)quinoline.

(8) ATP production inhibitors, such as (8.001) silthiofam.

(9) cell wall synthesis inhibitors such as (9.001) benthiavalicarb, (9.002) dimethomorph, (9.003) flumorph, (9.004) iprovalicarb, (9.005) mandipropamide, ( 9.006) pyrimorph, (9.007) valifenalate, (9.008) (2E)-3-(4-tert-butylphenyl)-3-(2-chloropyridin-4-yl)-1-( Morpholin-4-yl)prop-2-en-1-one, (9.009) (2Z)-3-(4-tert-butylphenyl)-3-(2-chloropyridin-4-yl)-1 -(morpholin-4-yl)prop-2-en-1-one.

(10) Inhibitors of synthesis of lipids and membranes, such as (10.001) propamocarb, (10.002) propamocarb hydrochloride, (10.003) tolclofos-methyl.

(11) Melanin biosynthesis inhibitors such as (11.001) tricyclazole, (11.002) 2,2,2-trifluoroethyl {3-methyl-1-[(4-methylbenzoyl)amino]butan-2-yl } Carbamate.

(12) nucleic acid synthesis inhibitors, such as (12.001) benalaxyl, (12.002) benalaxyl-M (chiralaxyl), (12.003) metalaxyl, (12.004) metalaxyl-M (mefenoxam).

(13) signal transduction inhibitors such as (13.001) fludioxonil, (13.002) iprodione, (13.003) procymidone, (13.004) proquinazide, (13.005) quinoxifene, (13.006) vinclozoline .

(14) Compounds capable of acting as deconjugation agents, such as (14.001) fluazinam, (14.002) meptyldinocap.

(15) additional compounds, such as (15.001) abscisic acid, (15.002) benthiazole, (15.003) bentoxazine, (15.004) capsimycin, (15.005) carbonone, (15.006) quinomethionate, (15.007) cupraneb, (15.008) cyflufenamide, (15.009) simoxanil, (15.010) ciprosulfamide, (15.011) flutianil, (15.012) fosetyl-aluminum, (15.013) fosetyl- Calcium, (15.014) fosetyl-sodium, (15.015) methyl isothiocyanate, (15.016) metraphenone, (15.017) mildiomycin, (15.018) natamycin, (15.019) dimethyldithiocarbamate nickel, ( 15.020) nitrotal-isopropyl, (15.021) oxamocarb, (15.022) oxathiapiproline, (15.023) oxyfenthiin, (15.024) pentachlorophenol and salts, (15.025) phosphonic acid and salts thereof, (15.026) propamocarb-fosetylate, (15.027) pyriophenone (chlazafenone), (15.028) tebufloquine, (15.029) teclophthalam, (15.030) tolniphanide, (15.031) 1-(4-{4-[(5R)-5-(2,6-difluorophenyl)-4,5-dihydro-1,2-oxazole- 3-yl]-1,3-thiazol-2-yl}piperidin-1-yl)-2-[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl] Ethanone, (15.032) 1-(4-{4-[(5S)-5-(2,6-difluorophenyl)-4,5-dihydro-1,2-oxazol-3-yl] -1,3-thiazol-2-yl}piperidin-1-yl)-2-[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]ethanone, ( 15.033) 2-(6-benzylpyridin-2-yl)quinazoline, (15.034) 2,6-dimethyl-1H,5H-[1,4]dithiino[2,3-c:5,6-c' ]dipyrrole-1,3,5,7(2H,6H)-tetron, (15.035) 2-[3,5-bis(difluoromethyl)-1H- Pyrazol-1-yl]-1-[4-(4-{5-[2-(prop-2-yn-1-yloxy)phenyl]-4,5-dihydro-1,2-oxa zol-3-yl}-1,3-thiazol-2-yl)piperidin-1-yl]ethanone, (15.036) 2-[3,5-bis(difluoromethyl)-1H-pyra zol-1-yl]-1-[4-(4-{5-[2-chloro-6-(prop-2-yn-1-yloxy)phenyl]-4,5-dihydro-1, 2-oxazol-3-yl}-1,3-thiazol-2-yl)piperidin-1-yl]ethanone, (15.037) 2-[3,5-bis(difluoromethyl)- 1H-Pyrazol-1-yl]-1-[4-(4-{5-[2-fluoro-6-(prop-2-yn-1-yloxy)phenyl]-4,5-di Hydro-1,2-oxazol-3-yl}-1,3-thiazol-2-yl)piperidin-1-yl]ethanone, (15.038) 2-[6-(3-fluoro- 4-Methoxyphenyl)-5-methylpyridin-2-yl]quinazoline, (15.039) 2-{(5R)-3-[2-(1-{[3,5-bis(difluoromethyl) -1H-pyrazol-1-yl]acetyl}piperidin-4-yl)-1,3-thiazol-4-yl]-4,5-dihydro-1,2-oxazol-5-yl }-3-Chlorophenyl methanesulfonate, (15.040) 2-{(5S)-3-[2-(1-{[3,5-bis(difluoromethyl)-1H-pyrazol-1-yl) ]Acetyl}piperidin-4-yl)-1,3-thiazol-4-yl]-4,5-dihydro-1,2-oxazol-5-yl}-3-chlorophenyl methanesulfonate , (15.041) 2-{2-[(7,8-difluoro-2-methylquinolin-3-yl)oxy]-6-fluorophenyl}propan-2-ol, (15.042) 2-{2 -fluoro-6-[(8-fluoro-2-methylquinolin-3-yl)oxy]phenyl}propan-2-ol, (15.043) 2-{3-[2-(1-{[3, 5-bis(difluoromethyl)-1H-pyrazol-1-yl]acetyl}piperidin-4-yl)-1,3-thiazol-4-yl]-4,5-dihydro-1 ,2-oxazol-5-yl}-3-chlorophenyl methanesulfonate, (15.044) 2-{3-[2-(1-{[3,5-bis(difluoromethyl)-1H-pyra) zol-1-yl]acetyl}piperidin-4-yl)-1,3-thiazol-4-yl]-4,5-dihydro-1,2-oxazol-5-yl}phenylmethanesulfo nate, (15.045) 2-phenylphenol and its salts, (1 5.046) 3-(4,4,5-trifluoro-3,3-dimethyl-3,4-dihydroisoquinolin-1-yl)quinoline, (15.047) 3-(4,4-difluoro- 3,3-Dimethyl-3,4-dihydroisoquinolin-1-yl)quinoline, (15.048) 4-amino-5-fluoropyrimidin-2-ol (tautomeric form: 4-amino-5-fluoro Lopyrimidin-2(1H)-one), (15.049) 4-oxo-4-[(2-phenylethyl)amino]butyric acid, (15.050) 5-amino-1,3,4-thiadiazole-2 -thiol, (15.051) 5-chloro-N'-phenyl-N'- (prop-2-yn-1-yl) thiophene 2-sulfonohydrazide, (15.052) 5-fluoro-2-[ (4-fluorobenzyl)oxy]pyrimidin-4-amine, (15.053) 5-fluoro-2-[(4-methylbenzyl)oxy]pyrimidin-4-amine, (15.054) 9-fluoro- 2,2-dimethyl-5-(quinolin-3-yl)-2,3-dihydro-1,4-benzoxazepine, (15.055) but-3-yn-1-yl {6-[({[ (Z)-(1-methyl-1H-tetrazol-5-yl)(phenyl)methylene]amino}oxy)methyl]pyridin-2-yl}carbamate, (15.056) (2Z)-3-amino-2 -Cyano-3-phenyl ethyl acrylate, (15.057) phenazine-1-carboxylic acid, (15.058) 3,4,5-trihydroxypropyl benzoate, (15.059) quinolin-8-ol, (15.060) quinoline -8-ol sulfate (2:1), (15.061) {6-[({[(1-methyl-1H-tetrazol-5-yl)(phenyl)methylene]amino}oxy)methyl]pyridin-2- One} tert-butyl carbamic acid.

Microbial agents, beneficial organisms, in particular bacteria, fungi, yeasts, plant extracts and products formed by microorganisms (eg, proteins and secondary metabolites), and the like.

bacteria such as spore-forming bacteria, bacteria that colonize roots and bacteria that act as biological insecticides, fungicides or nematicides, and the like.

Examples of such bacteria are:

Bacillus amyloliquefaciens strain FZB42 (DSM 231179) or Bacillus cereus, especially B. cereus strain CNCM I-1562 or Bacillus firmus strain I- 1582 (Accession No. CNCM I-1582) or Bacillus pumilus, especially strain GB34 (Accession No. ATCC 700814) and strain QST2808 (Accession No. NRRL B-30087) or Bacillus subtilis, especially strain GB03 (Accession No. ATCC SD-1397) or Bacillus subtilis strain QST713 (Accession No. NRRL B-21661) or Bacillus subtilis strain OST 30002 (Accession No. NRRL B-50421), Bacillus Bacillus thuringiensis, in particular B. thuringiensis subspecies israelensis (antigen type H-14) strain AM65-52 (accession number ATCC 1276) or Bacillus thuringiensis subspecies israelensis (B) thuringiensis subsp. aizawai), in particular strain ABTS-1857 (SD-1372) or B. thuringiensis subsp. kurstaki strain HD-1 or B. thuringiensis subspecies tenebrionis (B. thuringiensis) subsp. tenebrionis) strain NB 176 (SD-5428), Pasteuria penetrans, Pasteuria spp. (Rotylenchulus reniformis nematode)-PR3 (Accession No. ATCC SD-5834), Streptomyces microflavus (Streptomyc) es microflavus) strain AQ6121 (=QRD 31.013, NRRL B-50550), Streptomyces galbus strain AQ 6047 (accession number NRRL30232).

Examples of fungi and yeasts are:

Beauveria bassiana, in particular state ATCC 74040, Coniothyrium minitans, in particular state CON/M/91-8 (Accession No. DSM-9660), Lecanicillium spp. ), especially the strain HRO LEC 12, Lecanicillium lecanii (previously known as Verticillium lecanii), especially the strain KV01, Metarhizium anisopliae , especially strain F52 (DSM3884/ATCC 90448), Metschnikowia fructicola, especially strain NRRL Y-30752, Paecilomyces fumosoroseus (new: Isaria fumosoroseus) (Isaria fumosorosea)), in particular the state IFPC 200613 or the state Apopka 97 (accession number ATCC 20874), Paecilomyces lilacinus, in particular P. lilacinus, note 251 (AGAL 89/ 030550), Talaromyces flavus, especially strain V117b, Trichoderma atroviride, especially strain SC1 (Accession No. CBS 122089), Trichoderma harzianum, especially T. harzianum rifai T39 (Accession No. CNCM I-952).

Examples of viruses are:

Adoxophyes orana granule disease virus (GV), cydia pomonella granule disease virus (GV), tobacco moth (Helicoverpa armigera) nuclear polyhedron virus (NPV), Spodoptera exigua mNPV, Spodoptera frugiperda mNPV, African cotton leafworm (Spodoptera littoralis) NPV.

Bacteria and fungi which are added as "inoculum" to a plant or plant part or plant organ, and which promote plant growth and plant health by virtue of these specific properties are likewise included. Examples include:

Agrobacterium spp., Azorhizobium caulinodans, Azospirillum spp., Azotobacter spp., Bradyrhizobium pp. ), Burkholderia spp., in particular Burkholderia cepacia (previously known as Pseudomonas cepacia), Gigaspora spp. or Gigaspora monospo Gigaspora monosporum, Glomus spp., Laccaria spp., Lactobacillus buchneri, Paraglomus spp., Pysolitus tincture (Pisolithus tinctorus), Pseudomonas spp., Rhizobium spp., especially Rhizobium trifolii, Rhizobium trifolii, Rhizopogon spp., Scleroderma spp. ), Suillus spp., Streptomyces spp.).

Examples of plant extracts and products formed by microorganisms (which include proteins and secondary metabolites) are:

Garlic (Allium sativum), bitter gourd (Artemisia absinthium), azadirachtin, Biokeeper WP, Cassia nigricans, Celastrus angulatus, American sagebrush (Chenopodium anthelminticum), Chitin, Armor-Zen, Dryopteris filix-mas, Horsetail (Equisetum arvense), Fortune Aza, Fungastop, Heads Up (Chenopodium quinoa saponin extract), pyrethrum/pyrethrins, Surinamese oak ( Quassia amara), Quercus, Quillaja, Regalia, (「Requiem ^TM Insecticide」), rotenone, liana/ryanodine, comfrey (Symphytum officinale), mugwort (Tanacetum vulgare), thymol , Triact 70, TriCon, Tropaeulum majus, Urtica dioica, Veratrin, Viscum album, Brassicaceae extract, especially rapeseed powder or mustard powder.

The smectite mineral according to the present invention preferably includes montmorillonite, weidellite, nontronite, saponite, hectorite, soconite and stevensite. Bentonite containing montmorillonite as a main component is also included in the smectite mineral according to the present invention. Bentonite is suitable for the smectite mineral according to the present invention.

The alkylnaphthalenesulfonic acid derivative according to the present invention preferably includes sodium salt of naphthalenesulfonic acid formalin condensate and sodium salt of alkylnaphthalenesulfonic acid formalin condensate, and alkylnaphthalenesulfonic acid formalin condensate sodium salt is suitable.

The content rate of the alkylnaphthalenesulfonic acid derivative in the agrochemical granular composition of this invention is 0.1 to 2.0 weight% suitably, More preferably, it is 0.15 to 0.75 weight%, More preferably, it is 0.2 to 0.6 weight% .

The content rate of the pregelatinized starch in the agrochemical granular composition of this invention is 0.1 to 10 weight% suitably, More preferably, it is 0.2 to 5 weight%, More preferably, it is 0.5 to 3 weight%.

The content rate of the smectite mineral in the agrochemical granular composition of this invention is 1 to 50 weight% suitably, More preferably, it is 2 to 30 weight%, More preferably, it is 3 to 20 weight%.

The agrochemical granular composition of the present invention may further contain adjuvants such as extenders, water-soluble binders, surfactants, solvents, stabilizers, granulation accelerators, preservatives, colorants, pH adjusters, fragrances and the like.

Examples of the extender include clay, calcium carbonate, silica sand and pulverized products thereof, diatomaceous earth, talc, ziclerite, sericite, acid clay, activated clay, silica stone, pumice stone, zeolite, vermiculite, white carbon, shirasu balloon, and the like. inorganic carriers such as cellulose, pulp, rice husk, wood flour, starch, soybean flour and other water-insoluble organic matter carriers;

Water-soluble binders include sodium carboxymethylcellulose, hydroxypropylmethylcellulose, methylcellulose, methylethylcellulose, hydroxypropylcellulose, sodium polyacrylate, gum tragacanth, polyvinylpyrrolidone, polyvinyl alcohol, dextrin, alginic acid and Sodium alginate etc. are mentioned.

Nonionic surfactants, anionic surfactants, cationic surfactants, double-sided active agents, etc. are mentioned to surfactant.

For example, as a nonionic surfactant, polyoxyalkylene alkyl ether, polyoxyalkylene alkyl aryl ether, polyoxyalkylene allyl phenyl ether, polyoxyalkylene alkyl ester, polyoxyalkylene sorbitan alkylate, polyoxyalkyl A enephenyl ether polymer, polyoxyalkylene alkylene aryl phenyl ether, polyoxyalkylene alkylene glycol, a polyoxyethylene polyoxypropylene block polymer, etc. are mentioned.

Examples of the anionic surfactant include lignin sulfonate, alkylarylsulfonate, dialkylsulfosuccinate, polyoxyalkylenealkylarylethersulfate, alkylnaphthalenesulfonate, polyoxyalkyleneallylphenylethersulfate, laurylsulfate, and the like. can be heard

Examples of the cationic surfactant include alkyltrimethylammonium salts, alkyldimethylbenzylammonium salts, and alkylpyridinium salts.

Examples of the double-sided active agent include dialkyldiaminoethylbetaine and alkyldimethylbenzylbetaine. However, the surfactant which can be used in this invention is not limited to these illustrations, Even if it uses 1 type or 2 or more types together, there is no problem at all.

Examples of the pH adjuster include citric acid, malic acid, phosphoric acid, sodium citrate, potassium citrate, magnesium oxide, sodium carbonate, sodium hydrogen carbonate, disodium hydrogen phosphate, dipotassium hydrogen phosphate, trisodium phosphate, potassium pyrophosphate or sodium pyrrolate, or a hydrous product thereof. , anhydrous crystals, and the like. However, the pH adjuster which can be used in this invention is not limited to these illustrations, Even if it uses 1 type or 2 or more types together, there is no problem at all.

The agrochemical granular composition of this invention can be manufactured by a manufacturing method known per se. For example, agrochemical active ingredients, smectite minerals, pregelatinized starch, alkylnaphthalenesulfonic acid derivatives, and, if necessary, extenders, water-soluble binders, surfactants, solvents, stabilizers, pH adjusters, granulation accelerators, preservatives, coloring agents, fragrances, etc. Together, the desired agricultural chemical granules can be prepared by granulating by methods, such as a coating method and a kneading method.

In the case of coated granules, the agrochemical active ingredient, smectite mineral, pregelatinized starch, and alkylnaphthalenesulfonic acid derivative may be contained in the coating layer, or the absorbent granules may be impregnated.

In the case of producing coated granules, for example, a mixed solution of water and a surfactant is added to the grains and mixed, and the resulting mixture is obtained by adding agrochemical active ingredient, smectite mineral, pregelatinized starch, alkylnaphthalenesulfonic acid derivative, etc. After coating the bulk powder prepared by mixing and pulverizing, drying, if necessary, pulverization, sieving, sizing, etc. can be performed to produce a desired agrochemical granule.

In the coated granule, examples of the nuclei include calcium carbonate components such as limestone and marble, silica sand, pumice stone, clay particles, and granulated inorganic substance particles.

On the other hand, in the case of producing dough granules, the agrochemical active ingredient, smectite mineral, pregelatinized starch, alkylnaphthalenesulfonic acid derivative, and other above-mentioned auxiliary are mixed together, and water is added to mix or knead well, granulation, and granulation obtained Desired pesticide granules can be manufactured by drying water and, if necessary, pulverizing, sieving, sizing, and the like.

A kneader is used for the kneading. Examples of the kneader include a universal mixer, a kneader, a Loedige mixer, and a vertical granulator.

The amount of water used at the time of kneading is usually 5 to 20 parts by weight based on 100 parts by weight of the mixture.

In the case of producing the dough granules, it is usually performed using a screen of 0.3 to 1.8 mm phi, preferably 0.8 to 1.2 mm phi.

As the granulator used, a screw type extrusion granulator, a roll type extrusion granulator, a disk pellet type extrusion granulator, a pellet mill type extrusion granulator, a basket type extrusion granulator, a plate type extrusion granulator, an oscillating type extrusion granulator, a gear type extrusion granulator, a ring die type Extrusion granulator etc. are mentioned, Specifically, Multigran MG-55-2; DALTON CORPORATION is available.

The obtained granulated product is usually dried at 50 to 120°C, preferably at 60 to 80°C.

The agrochemical granular composition of the present invention can be applied at any time from before sowing to the same time as transplanting.

In the application before sowing, for example, a method of putting a mixture of an agricultural chemical granular composition and top soil into a seedling box and then sowing a seed is exemplified.

In application at the time of sowing, the method of spraying a solid agrochemical composition after seed sowing and before cover is mentioned.

In the application at the time of transplantation, for example, a method of spraying a pesticide granular composition in a seedling box a few days before or on the day before transplanting a seedling into a rice paddy or a field, a method of transplanting a seedling with a rice planting device, etc. and spraying a solid pesticide composition with a duster and the like.

The agrochemical granular composition of this invention can be applied to a seedling box by arbitrary methods. For example, in addition to the above-mentioned mixing with the top soil, a spreader may be used.

The seedling box that can be used in the method of the present invention includes a rice seedling box, a cell tray for horticultural crops (vegetables, fruit trees, flowers), and a plastic container.

In the method of the present invention, when the solid pesticide composition is applied to a rice seedling box, the application amount is usually 10 to 200 g, preferably 50 to 100 g per one seedling box. In the case of application in plastic containers such as the seedling box 448 holes for the Minoru pot system (manufactured by Minoru Sangyo Co., Ltd.), it is usually 33 to 66 g per container (1 to 2 kg per 10 a).

The agrochemical granular composition for the application of the rice seedling box of this invention can be obtained with the granulation method normally used in formulation of an agrochemical. For example, agrochemical active ingredient, alkylnaphthalenesulfonic acid derivative, pregelatinized starch, smectite mineral, surfactant, water-soluble binder, solvent, adjuvant, extender, etc. are added as necessary, and vertical granulator (trade name manufactured by Paurek Corporation) After mixing and pulverizing with a furnace, water is added and kneaded, granulated using an extrusion granulator, dried with a fluidized bed dryer, and granulated to prepare. In addition, granulation with an electric granulator while adding water to the powder mixture, drying and sizing may be performed, or a fluidized bed granulator can be produced by spraying a binder, aqueous solution or active ingredient while the powder mixture is flowing. .

In addition, the dosage form that can be taken by the granular material for application in a rice seedling box of the present invention is not limited in any way as long as it is a solid preparation other than powder form such as granules, granules, and tablets.

Example

Next, the present invention will be described in more detail by way of Preparation Examples, Examples, Comparative Examples and Test Examples, but the present invention is not limited thereto.

Among the substances used in this example, those requiring special explanation are described below.

Isothianil is a known compound, and it can be prepared, for example, by the method described in International Publication No. 99/024413 pamphlet.

Fenflufen is a known compound, for example, it can be prepared by the method described in the pamphlet of International Publication No. 2003/010149.

Tetraniliprole is a known compound, and can be prepared, for example, by the method described in International Publication No. 2011/157664 pamphlet.

Examples of the alkylnaphthalenesulfonic acid derivative include MorwetD425 (manufactured by Akzo Nobel), TERSPERSE2020 (manufactured by Hanzman Corporation), and Agrosurf WG-2300 (manufactured by Takemoto Yuji Co., Ltd.).

As the pregelatinized starch, for example, Amicol HF, Amicol C, Amicol KF, Amicol HG-N, Amicol BJ-2, Amicol W, starch MH-A, Amicol A, Amicol FW (Nichideng Chemical) Co., Ltd.), Japanese Alster, Japanese Alster H, Japanese Waxy-α (manufactured by Nippon Shoku Hinga Co., Ltd.), Corn αY, Corn αS-1, Industrial Tapioca α, Industrial Tapioca αTP-2, Wheat starch αWA-105 (manufactured by Sanwa Denpun Kogyo Co., Ltd.), Amilox No. 1, Amilox No. 1A (made by Nippon Cornstarch Co., Ltd.) etc. are mentioned.

Suitable smectite minerals include montmorillonite, for example, bentonite fuji, bentonite hotaka, bentonite akagi, bentonite myogi, super clay (manufactured by Hojun Corporation), Kunigel V1, Kunigel V2, Kunigel VA, Bentonite, such as Kunibond (made by Kunimine Kogyo Co., Ltd.) and Kansai bentonite (made by Kanesan Kogyo Co., Ltd.), is mentioned.

The solid components in the amounts shown in Table 1 are mixed using a universal mixing stirrer (5DM-L-03-r; DALTON CORPORATION), and the liquid soluble components therein are dissolved in an optimal amount of water (equivalent to 13.5% of the mixture) After adding and mixing and kneading for 2 minutes, extrusion granulation from a screen having a mesh diameter of 1.0 mm using a granulator (Multigran MG-55-2; manufactured by DALTON CORPORATION), and a dryer (FD-LAB-1; POWREX CORPORATION) production), the granulated product was dried at 80°C. Finally, it was sieved with a sieve of 1.4 mm and 0.5 mm mesh size to obtain a pesticide granular composition of the present invention and a comparative pesticide granular composition.

ingredient Example 1 Example 2 Example 3 isotianil 2.00 2.00 2.00 fenflufen 2.00 2.00 2.00 tetraniliprol 1.50 1.50 1.50 pregelatinized starch 2.00 2.00 2.00 Alkylnaphthalenesulfonic acid formalin condensate sodium salt 0.5 0.25 0 Carboxymethylcellulose sodium salt 1.00 1.00 1.00 Polyoxyalkylene Allylphenylether Sulfate Sodium Salt 2.00 2.00 2.00 dialkylsulfosuccinic acid ester salt 0.03 0.03 0.03 smectite mineral 15.00 15.00 15.00 citric acid anhydride 0.30 0.30 0.30 white carbon 1.14 1.14 1.14 clay 72.53 72.78 73.03

Growth test on rice by pretreatment with soil for sowing of water supply

Using a small water seedling box (about 1/12 the size of a normal seedling box 30 cm × 60 cm), the blank granular composition is treated at a ratio of 8.3 g / seedling box before planting at the time of sowing, 12.5 g of dried rice seeds (variety: Koshihikari) were sown. After making it germinate for 66 hours in the seedling stage (28 degreeC all day), seedling was performed with the hotbed mat (20 degreeC) in a plastic house. After seedling for 21 days, the root tensile strength of rice (treated group) was measured. The root tensile strength of the treated group and the root tensile strength of the untreated group were compared by Equation 1 to calculate the growth rate (%), and the growth status was evaluated according to the following criteria.

[Formula 1]

Growth rate = (root tensile strength [N/m ² ])/(root tensile strength of untreated group [N/m ² ])

<<judgment standard of the growth situation>>

Agrochemical granular composition (Table 1) Growth rate (%) Growth rate determination Example 1 103.4% -- Example 2 94.6% - Comparative Example 1 77.0% +

It was demonstrated from the result of the growth test with respect to the said rice that the agricultural chemical granular composition of this invention has the outstanding weak damage alleviation effect.

Claims (6)

Agrochemical granular composition for rice seedling box application, characterized by containing an agrochemical active ingredient, an alkylnaphthalenesulfonic acid derivative, a pregelatinized starch, and a smectite mineral. The agrochemical granular composition according to claim 1, wherein the content of the agrochemical active ingredient is 1 to 30% by weight. The agrochemical granular composition according to claim 1 or 2, wherein the content of the alkylnaphthalenesulfonic acid derivative is 0.1 to 2.0% by weight. The agrochemical granular composition according to any one of claims 1 to 3, wherein the content of the pregelatinized starch is 0.1 to 10% by weight. The agrochemical granular composition according to any one of claims 1 to 4, wherein the smectite mineral is bentonite. The agrochemical granular composition according to any one of claims 1 to 5, wherein the content of the smectite mineral is 1 to 50% by weight.