WO2021143894A1 - Appareil pour l'obtention de micro-gouttelettes - Google Patents

Appareil pour l'obtention de micro-gouttelettes Download PDF

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Publication number
WO2021143894A1
WO2021143894A1 PCT/CN2021/072373 CN2021072373W WO2021143894A1 WO 2021143894 A1 WO2021143894 A1 WO 2021143894A1 CN 2021072373 W CN2021072373 W CN 2021072373W WO 2021143894 A1 WO2021143894 A1 WO 2021143894A1
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WO
WIPO (PCT)
Prior art keywords
main body
droplets
obtaining micro
space
actuating
Prior art date
Application number
PCT/CN2021/072373
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English (en)
Chinese (zh)
Inventor
吴明翰
吴思仪
Original Assignee
吴明翰
吴思仪
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 吴明翰, 吴思仪 filed Critical 吴明翰
Priority to JP2022600085U priority Critical patent/JP3240349U/ja
Publication of WO2021143894A1 publication Critical patent/WO2021143894A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe

Definitions

  • the present invention relates to a device for obtaining trace droplets, in particular to a device for obtaining trace eye drops from a drip opening.
  • the purpose of the present invention is to provide a device for obtaining micro-droplets, which has a simple structure and convenient operation, can provide better use performance, better provide micro-droplets, and achieve a better therapeutic effect.
  • the present invention discloses a device for obtaining micro-droplets, which is characterized in that it comprises:
  • a body having a surface that accepts droplets from the drip opening
  • a storage space is formed on the surface of the body and only retains 0.1-95% of the total volume of the droplets.
  • the storage space is a groove recessed from the surface of the main body.
  • the surface of the body is a flat surface
  • the diameter of the flat surface is between 1 to 5 mm
  • the diameter of the groove is between 1 to 4 mm
  • the depth of the groove is between 0.5 to 1 mm.
  • the groove has a V-shaped or U-shaped longitudinal section, and the depth of the groove is between 0.5 and 1 mm.
  • the main body is made of non-absorbent foam
  • the rear end of the main body is provided with a joint part
  • the whole of the main body and the joint part forms an L-shaped section.
  • the surface of the main body is inclined.
  • the main body includes a front end and a rear end separated from the front end and connected to one end of a handle, the main body has a first axis passing through the front end and the rear end, and the handle includes a longitudinal direction An extended second axis, where the first axis and the second axis intersect to form an included angle greater than 90 degrees and less than 180 degrees.
  • the end of the grip further includes a mirror body, the mirror body includes a mirror surface facing the user's eyes, and the mirror surface of the mirror body is connected to the rear end of the body.
  • the casing surrounds a space with an upper opening.
  • the actuating unit is connected with the main body and can drive the main body to move in and out of the space.
  • an upper cover having a mirror surface and capable of opening and closing the upper opening.
  • the storage space is a lower surface extending from the surface of the main body to the rear end.
  • the present invention can be used to provide users (such as children) to obtain micro-droplets (such as eye drops), and the obtained micro-droplets can form a suspension due to the effect of adhesion and surface tension for the user to use , And can ensure the convenience and safety of use.
  • the method for obtaining micro-droplets of the present invention can facilitate users (such as children) to obtain the required micro-droplets from a container (such as an eye drop bottle).
  • Figure 1 A perspective view of the device of the first embodiment of the present invention.
  • Figure 2 Shows a cross-sectional view of the device of Figure 1.
  • Figure 3 A partial enlarged view of the device of Figure 2 is shown.
  • Figure 4 A schematic diagram showing the dropping of a drop from a container onto the device of Figure 1.
  • Fig. 5 A schematic diagram showing a part of the device of Fig. 4 that receives a droplet.
  • Fig. 6 A cross-sectional view similar to Fig. 3 showing the device of the second embodiment of the present invention.
  • Fig. 7 A schematic diagram showing the application of eye drops received by the device of Fig. 1 to the eyes of a user.
  • Figure 8 A cross-sectional view of the device of the third embodiment of the present invention.
  • Figure 9 A cross-sectional view of the device of the fourth embodiment of the present invention.
  • Fig. 10 A schematic diagram showing the part of the device of Fig. 9 that receives a droplet.
  • Fig. 11 A perspective view of the device of the fifth embodiment of the present invention, and shows that the device receives a liquid drop.
  • Fig. 12 A schematic diagram showing the application of eye drops received by the device of Fig. 11 to the eyes of a user.
  • Fig. 13 A perspective view of the device of the sixth embodiment of the present invention.
  • Fig. 14 A side view of the device of the seventh embodiment of the present invention.
  • Fig. 15 A side view of the device of the eighth embodiment of the present invention.
  • Fig. 16 An exploded view of the device of the ninth embodiment of the present invention.
  • Fig. 17 A schematic diagram showing the device of Fig. 16 receiving a part of a droplet.
  • Fig. 18 A cross-sectional view taken along line 18-18 of Fig. 17.
  • Fig. 19 A cross-sectional view showing the upper end of the main body of Fig. 18 moved out of the space.
  • Fig. 20 A schematic diagram showing the application of eye drops received by the device of Fig. 19 to the eyes of a user.
  • Fig. 21 An exploded view of the device of the tenth embodiment of the present invention.
  • Fig. 22 A schematic diagram showing the device of Fig. 21 receiving a part of a droplet.
  • Fig. 23 A perspective view showing the upper end of the main body of Fig. 22 moved out of the space.
  • the device 10 includes a body 12 and a storage space 14.
  • the body 12 has a surface 16 capable of receiving liquid droplets 15.
  • the accommodating space 14 is provided on the surface 16 of the main body 12 and can only store a part of the liquid droplets 15 received by the surface 16 (see FIG. 5).
  • the main body 12 can be made of materials such as non-absorbent foam, silica gel, plastic, rubber and the like.
  • the main body 12 is a column with a circular cross-section and a tapered shape with a narrow top and a wide bottom so as to be stably placed on an object 24 such as a table top.
  • the column includes a A front end 18 and a rear end 20.
  • the surface 16 is formed on the upper end surface of the front end 18 and is a flat surface, and the rear end 20 has a lower surface 22.
  • the surface 16 has a first diameter (d1).
  • the first diameter (d1) is less than 6 millimeters (mm) and preferably between 1 and 5 mm.
  • the storage space 14 is a groove recessed from the surface 16 of the main body 12, the groove having a circular cross section and a circular arc concave (or U-shaped) longitudinal section, as shown in FIG. 3 Shown.
  • the storage space 14 has a second diameter (d2) and a depth (D) on the surface 16, and the second diameter (d2) is smaller than the first diameter (d1).
  • the size, shape, and depth of the storage space 14 can be changed according to requirements.
  • the second diameter (d2) is less than 5 millimeters (mm) and preferably between 1 to 4 mm, and the depth (D) of the storage space 14 is between 0.5 to 1 millimeter (mm),
  • the storage space 14 can store 0.1-95% of the total volume of the liquid droplets 15 received by the surface 16.
  • the portion of the droplet 15 remaining in the storage space 14 may become a suspension due to the action of adhesion and surface tension.
  • the storage space 14 has a longitudinal section that is generally V-shaped, as shown in FIG. 6.
  • Figures 4 and 5 show an embodiment of the device 10 for obtaining micro-droplets, in which a container (such as an eye drop bottle) 26 containing a liquid such as distilled water, syrup or eye drops is located above the surface 16 of the body 12 ( For example, 1 cm above the surface 16), and a droplet 15 drops from the drip opening 27 of the container 26 to the surface 16 of the body 12.
  • a container such as an eye drop bottle
  • a liquid such as distilled water, syrup or eye drops
  • the liquid when the first diameter (d1) of the surface 16 is 3mm and the second diameter (d2) of the storage space 14 (U-shaped section) is 2mm, the liquid can be obtained on the surface 16 of the body 12 About 23% of the total volume of the droplet 15; when the first diameter (d1) of the surface 16 is 3mm and the second diameter (d2) of the storage space 14 (V-shaped section) is 2mm, the total volume of the droplet 15 can be obtained About 7% by volume; when the first diameter (d1) of the surface 16 is 4mm and the second diameter (d2) of the storage space 14 (U-shaped section) is 1mm, about 7% of the total volume of the droplet 13 can be obtained.
  • the droplet 15 in FIG. 5 is from about 1.5 cm ( cm)
  • the droplet 15 is dropped. At this time, the volume percentage of the total volume of the droplets 15 received by the surface 16 will decrease.
  • the minute droplets obtained by the device 10 will not fall down in the vertical or inverted state, but the first diameter (d1) of the surface 16 In the embodiment where d1) is 5 mm or more, the minute droplets obtained by the device 10 may fall down in a vertical or inverted state.
  • Fig. 7 shows an application of the device 10 of the present invention after obtaining micro-droplets.
  • the minute droplets received by the device 10 are eye drops dropped from an eye drop bottle (see Figure 4), and the device 10 can be in an inverted state to spot the obtained minute droplets on the user's eyes (see Figure 4). 7).
  • the index finger 28 can be used to pull down the lower eyelid 30, and then the surface 16 of the body 12 Under and close to the eye 32, the trace amount of eye drops carried on the surface 16 can be easily dropped into the groove between the white of the eye and the lower eyelid to complete the application of eye drops.
  • the minute droplets obtained by the device 10 are not limited to eye drops, and other liquids that can form droplets are also applicable.
  • a drop for example, a drop of eye drops
  • the surface 16 of the device 10 of the present invention can be used to receive the full amount of the drop.
  • the volume percentage of 0.1-95%. That is, when the first diameter (d1) of the surface 16 of the device 10 and the second diameter (d2) of the storage space 14 are matched in various sizes, the device 10 of the present invention can obtain 0.03 to 47.5 microliters ( ⁇ L) micro-droplets. Accordingly, in the application of droplets as eye drops, the device 10 of the present invention will be able to obtain 0.03 to 47.5 microliters of eye drops according to the size of the storage space 14, especially less than 28 microliters of eye drops.
  • the device 10 of the present invention can be given to a patient (such as a child) by a physician for use, because the physician knows the correct dose required by the patient approximately what volume percentage of the total dose.
  • Fig. 8 shows a device 10 according to a third embodiment of the present invention.
  • the surface 16 of the body 12 is inclined, so that when the distance between the drip opening 27 and the surface 16 is less than, for example, 0.5 cm, it can ensure self-control. Most of the droplets 15 dropped by the drip opening 27 slide off the inclined surface 16 and only a small amount of droplets remain in the storage space 14 and a part of the surface 16.
  • the inclined surface 16 has a high point 161 and a low point 162 opposite to each other. When the storage space 14 is set close to the high point 161, the transfer of the eye drops from the drip opening 27 to the eye can be improved. Ease.
  • Figures 9 and 10 show a device 10 according to a fourth embodiment of the present invention.
  • the storage space 14 extends from the surface 16 of the main body 12 to the lower surface 22 of the rear end 20 to facilitate the formation of the The storage space 14 allows the storage space 14 to store 0.1-95% of the total volume of the liquid droplets 15 received by the surface 16.
  • Figure 11 shows a device 10 according to a fifth embodiment of the present invention.
  • the main body 12 is made of a tapered cylinder made of non-absorbent foam, and the rear end 20 of the main body 12 is provided with a joint 35.
  • the extension direction of 35 is substantially perpendicular to the extension direction of the main body 12.
  • a handle 36 is detachably connected to one end of the joint 35 for the user to hold.
  • the material of the grip 36 may be plastic, and the extension direction of the grip is substantially perpendicular to the extension direction of the main body 12.
  • the user can see the position of the grip 36, and therefore does not It is feared that the main body 12 will touch the eyes, which can increase the safety of use.
  • the body 12 and the joint 35 form an L-shaped cross-section as a whole, which can reduce the impact force that may be caused by the user and further improve the safety of use.
  • FIG. 13 shows a device 10 according to a sixth embodiment of the present invention.
  • the body 12 is a cylinder
  • the handle 36 is directly coupled to the rear end 20 of the body 12 for the user to hold.
  • the handle 36 The extension direction of the main body 12 is perpendicular to the extension direction.
  • FIG. 14 shows a device 10 according to a seventh embodiment of the present invention.
  • the handle 36 is directly coupled to the rear end 20 of the main body 12 for the user to hold.
  • the body 12 defines an axis X1 passing through the front end 18 and the rear end 20, and the grip 36 defines an axis X2 extending along its length.
  • the axis X1 and the axis X2 intersect to form a clamp between 90-180 degrees.
  • Angle A, the included angle A is preferably between 100 degrees and 170, so that the surface 16 is inclined to achieve the implementation effect of the device 10 in FIG. 8 described above.
  • FIG. 15 shows the device 10 of the eighth embodiment of the present invention.
  • one end of the grip 36 further includes a mirror body 37, and the mirror surface 371 of the mirror body 37 and the body 12
  • the rear end 20 is connected to allow the user to observe the distance and relative position of the droplet attached to the surface 16 to the eye, thereby assisting the user to transfer the eye drops to the conjunctival sac more accurately.
  • Figures 16 to 19 show a device 10 according to a ninth embodiment of the present invention.
  • the device 10 of this embodiment further includes a housing 40 and an actuation unit 50.
  • the housing 40 defines a space 400 and includes the spaces respectively communicating with each other.
  • the upper opening 401 and the lower opening 402 of the 400 and the two first guiding portions 403 separately provided on the inner wall of the housing 40.
  • the actuating unit 50 includes an actuating portion 51 and a driven portion connected to the actuating portion 51 52 and a connecting portion 53, the actuating portion 51 is rotatably provided in the lower opening 402, the connecting portion 53 is driven by the actuating portion 51 to move up and down relative to the driven portion 52, the connecting portion 53 is connected
  • the main body 12 and the driven portion 52 are such that the main body 12 is connected to the actuating unit 50 and can be actuated by the actuating unit 50 to move in the space 400 and outside the space 400 and interact with the housing 40
  • the inner surface is separated by a gap 54.
  • it further includes an upper cover 404 pivotally connected to the housing 40 and openably closing the upper opening 401.
  • At least one side of the upper cover 404 includes a mirror surface 4041.
  • a liquid absorbing member 406 is provided below.
  • the liquid absorbing member 406 has a second guiding portion 4061 that cooperates with the first guiding portions 403, and the first and second guiding portions 403, 4061 are matched in a concave-convex pattern.
  • the first guiding portion 403 is convex
  • the second guiding portion 4061 is concave.
  • Figures 21 to 23 show the device 10 of the tenth embodiment of the present invention.
  • the device 10 of this embodiment further includes a housing 60 and an actuation unit 70.
  • the upper opening 601 and the lower opening 602 at the opposite ends of the space 600 and a sliding groove 604 communicating with the space 600 are provided with a plurality of concave portions 605 on both sides of the sliding groove 604.
  • the actuating unit 70 includes an actuating portion 71 and a connection Part 72, the actuating part 71 can move up and down relative to the sliding groove 604 and includes two elastic arms 711 and two fixing blocks 712 respectively connected with the elastic arms 711.
  • Each elastic arm 711 can provide a The elastic restoring force of the block 712 against the concave portions 605 is fixedly pressed, and the connecting portion 72 connects the main body 12 and the actuating portion 71. It must be noted that the device 10 of this embodiment may further include a liquid absorbing member 406 as shown in FIG. 16 and an upper cover 404 with a mirror surface.
  • the method for obtaining micro-droplets using the present invention includes providing a container 26 with a drip opening 27 in which liquid is contained; providing a device 10 for obtaining micro-droplets as in the above-mentioned embodiment; and placing the container 26 The liquid inside drips a drop 15 from the drip opening 27 to the surface 16 of the body 12 of the device 10 so that a part of the drop 15 is received in the storage space 14 of the body 12.
  • the device 10 of the present invention can directly contact the drip opening 27 of the container with the surface 16 of the body 12, and squeeze the container 26 so that a part of the droplets of the liquid inside the container 26 can be received by the device 10 of the present invention.
  • the effect of obtaining a small amount of liquid droplets is achieved.

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  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)

Abstract

La présente invention concerne un appareil (10) pour l'obtention de micro-gouttelettes. L'appareil comprend un corps (12) et un espace de réception (14). Le corps (12) est pourvu d'une surface (16) sur laquelle une gouttelette (15) peut être maintenue. L'espace de réception (14) est formé dans la surface (16) du corps (12) et peut réserver seulement une partie de la gouttelette (15) maintenue sur la surface (16). L'appareil (10) a une structure simple et un fonctionnement pratique, peut fournir de meilleures performances d'utilisation, et permettre une distribution de micro-gouttelettes, de façon à obtenir un meilleur effet de traitement.
PCT/CN2021/072373 2020-01-19 2021-01-18 Appareil pour l'obtention de micro-gouttelettes WO2021143894A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2022600085U JP3240349U (ja) 2020-01-19 2021-01-18 微量な液滴を取得するのに用いる装置

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN202020116283.7U CN212699642U (zh) 2020-01-19 2020-01-19 用于取得微量液滴的装置
CN202020116283.7 2020-01-19

Publications (1)

Publication Number Publication Date
WO2021143894A1 true WO2021143894A1 (fr) 2021-07-22

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PCT/CN2021/072373 WO2021143894A1 (fr) 2020-01-19 2021-01-18 Appareil pour l'obtention de micro-gouttelettes

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JP (1) JP3240349U (fr)
CN (1) CN212699642U (fr)
WO (1) WO2021143894A1 (fr)

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN201612737U (zh) * 2010-03-10 2010-10-27 苏华 眼药水点眼器
CN101990631A (zh) * 2008-02-15 2011-03-23 3M创新有限公司 样品采集装置
CN102847567A (zh) * 2012-08-24 2013-01-02 浙江硕华医用塑料有限公司 微量取样棒
CN104492508A (zh) * 2014-11-13 2015-04-08 浙江大学 一种基于液体残留的超微量液滴操控装置及方法
CN204909808U (zh) * 2015-09-08 2015-12-30 福州博中技术开发有限公司 眼部辅助给药装置
US20160032238A1 (en) * 2013-03-13 2016-02-04 Innovative Surface Technologies, Inc. Conical devices for three-dimensional aggregate(s) of eukaryotic cells
US20170023446A1 (en) * 2015-02-20 2017-01-26 Neoteryx, Llc. Method and apparatus for acquiring blood for testing

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101990631A (zh) * 2008-02-15 2011-03-23 3M创新有限公司 样品采集装置
CN201612737U (zh) * 2010-03-10 2010-10-27 苏华 眼药水点眼器
CN102847567A (zh) * 2012-08-24 2013-01-02 浙江硕华医用塑料有限公司 微量取样棒
US20160032238A1 (en) * 2013-03-13 2016-02-04 Innovative Surface Technologies, Inc. Conical devices for three-dimensional aggregate(s) of eukaryotic cells
CN104492508A (zh) * 2014-11-13 2015-04-08 浙江大学 一种基于液体残留的超微量液滴操控装置及方法
US20170023446A1 (en) * 2015-02-20 2017-01-26 Neoteryx, Llc. Method and apparatus for acquiring blood for testing
CN204909808U (zh) * 2015-09-08 2015-12-30 福州博中技术开发有限公司 眼部辅助给药装置

Also Published As

Publication number Publication date
JP3240349U (ja) 2022-12-28
CN212699642U (zh) 2021-03-16

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