WO2021143209A1 - 一种适用于婴儿皮肤的洗手液的制备方法 - Google Patents

一种适用于婴儿皮肤的洗手液的制备方法 Download PDF

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WO2021143209A1
WO2021143209A1 PCT/CN2020/119025 CN2020119025W WO2021143209A1 WO 2021143209 A1 WO2021143209 A1 WO 2021143209A1 CN 2020119025 W CN2020119025 W CN 2020119025W WO 2021143209 A1 WO2021143209 A1 WO 2021143209A1
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skin
molecular sieve
hand sanitizer
carbon
carbon molecular
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English (en)
French (fr)
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应光辉
应宗效
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浙江神英科技股份有限公司
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9794—Liliopsida [monocotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9789—Magnoliopsida [dicotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/005—Antimicrobial preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/10—Washing or bathing preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
    • A61K2800/28—Rubbing or scrubbing compositions; Peeling or abrasive compositions; Containing exfoliants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/59—Mixtures
    • A61K2800/592—Mixtures of compounds complementing their respective functions
    • A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
    • A61K2800/82—Preparation or application process involves sonication or ultrasonication
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Definitions

  • the invention relates to the technical field of hand sanitizer, and in particular to a preparation method of hand sanitizer suitable for baby skin.
  • Hand sanitizer is a skin care cleanser that mainly cleans hands. It uses mechanical friction and surface active agents to remove dirt and attached bacteria from hands with water flow.
  • the purpose of hand washing is to remove the stains and bacteria on the hands. Therefore, the detergency is the first consideration, but the detergency and degreasing power are directly proportional. Excellent detergency is accompanied by a strong degreasing effect. , Should choose mild non-irritating surfactants.
  • the decontamination ingredients in traditional hand sanitizers are to provide decontamination and abundant foam, mainly anionic surfactants and a small amount of nonionic and zwitterionic surfactants.
  • Anionic surfactants include soap, sodium lauryl sulfate, Q-olefin sulfonate, fatty alcohol polyoxyethylene ether sulfate, Q-sulfo fatty acid ester, lauroyl sarcosinate and monooleic acid amide sulfonate Disodium succinate and so on. Soap and sodium lauryl sulfate are the earliest surfactants used in hand sanitizers.
  • Non-ionic surfactants are generally seldom used in hand sanitizers, and a small amount of addition can enhance the decontamination effect and improve the stability of the foam, such as coconut diethanolamide, in which the addition of alkyl glycosides can reduce the effect of surfactants. Skin irritation.
  • the addition of a small amount of zwitterions is conducive to foaming and lasting foam, betaine and amine oxide.
  • sanitizers contain bactericides such as potassium iodide, nano-silver oxide, and triclosan. These bactericides may cause discomfort to children and irritate the skin during use. To harm.
  • Chinese invention patent CN109199963A discloses a special herbal hand sanitizer for infants and young children and its preparation method.
  • the product uses Streptomyces vulgaris as a fermentation strain and is activated into liquid fermented seeds, and then dandelion, honeysuckle, pear cactus, and small Thistle and water are mixed in a mixing tank at a ratio of 2:1:3:1:5 by weight, and then broken, pulped, sterilized, cooled, inoculated with liquid fermented seeds, fermented, centrifuged to remove impurities, concentrated, and extracted.
  • the herbal extract is made into a non-toxic, harmless, and technical effect with little skin irritation.
  • the antibacterial effect of the hand sanitizer is not ideal, and the hand sanitizer ignores the improvement effect on sensitive baby skin, so it is necessary to study a hand sanitizer suitable for baby skin.
  • the present invention proposes a method for preparing a hand sanitizer suitable for baby skin.
  • a preparation method of hand sanitizer suitable for baby skin includes the following steps:
  • the carbon molecular sieve carbon material is 5- Activate with 12% acetic acid pickling, then wash with water to neutrality, then ultrasonically crush for 10-15min under the conditions of ultrasonic power of 1000-1200W and material-to-liquid ratio of 1:(15-20), then pass through a 1250 mesh sieve, The filtrate of carbon-containing molecular sieve is obtained;
  • the hand sanitizer suitable for baby skin is composed of the following components by weight percentage: 3-10% of skin-friendly carbon molecular sieve suspension, 2-10% of natural plant flavor, and lauryl amidopropyl betaine 1- 5%, glycerin 2-12%, sodium chloride 1-3%, glycerol 0.8-2.5%, coconut acid 1-8%, citric acid 1-5% and the balance of water.
  • the hand sanitizer suitable for baby skin is composed of the following components by weight percentage: 5-8% of skin-friendly carbon molecular sieve suspension, 3-6% of natural plant flavor, and lauramidopropyl betaine 2 -4%, glycerin 4-10%, sodium chloride 1.5-2.5%, glycerol 1.2-2%, coconut acid 3-6%, citric acid 2-4% and the balance of water.
  • the content of the carbon molecular sieve in the filtrate of the carbon-containing molecular sieve is 2-5%.
  • the weight ratio of the aloe vera, tuber long, pueraria lobata root, white fresh peel and sophora flavescens is (1-3):(4-10):(3-8):( 3-8): (2-5).
  • the solid content of the concentrated solution is 20-35%.
  • the mass ratio of the filtrate of the carbon-containing molecular sieve to the concentrated liquid is 100:(0.5-3).
  • Aloe (namely Aloe vera) is one of the few edible species in the genus Aloe, and its products are widely used in food, beauty, health, medicine and other fields.
  • the polysaccharides and multiple vitamins contained in aloe have good nutrition, moisturizing and whitening effects on human skin. It has the properties of astringent, softening, moisturizing, anti-inflammatory and bleaching of the skin. It also relieves hardening, keratosis, and improves scars. It not only prevents small wrinkles, eye bags, and sagging skin, but also keeps the skin moist and delicate. At the same time, it can also treat skin inflammation. It is effective against acne, freckles, acne, and burns. Injuries, insect bites, etc. also have a good effect.
  • Pueraria lobata the name of traditional Chinese medicine. It is the dry root of the leguminous plant Pueraria lobata, commonly known as Pueraria lobata. Excavated in autumn and winter, cut into thick slices or small pieces while fresh; dry. Sweet, pungent, and cold. It has the functions of relieving muscles and reducing fever, removing rash, producing body fluid to quench thirst, and promoting Yang to stop diarrhea. It is often used for symptoms of fever, strong nape and back pain, impervious measles, thirst due to fever, yin deficiency to reduce thirst, heat diarrhea, diarrhea, spleen deficiency and diarrhea.
  • White fresh skin alias: white moss skin, eight-legged cow, mountain peony, sheep fresh grass, Latin name: CORTEX DICTAMNI Chinese medicine name. It is the root bark of the perennial herb of the Rutaceae family Baixian and Narrow-leaf Baixian. Mainly produced in Liaoning, Hebei, Sichuan, Jiangsu and other places. The roots are excavated in spring and autumn to remove the sand and coarse bark, peel off the root bark, slice it, and dry it. For life. It has the effects of clearing away heat and dampness, expelling wind and detoxification.
  • Sophora flavescens the name of Chinese medicine. It is the dried root of the legume Sophora flavescens. It is excavated in spring and autumn to remove the roots and small branched roots, wash and dry, or slice and dry when fresh. It's bitter and cold. It has the power of clearing heat and dampness, killing insects and diuresis. It is used for heat dysentery, blood in the stool, jaundice and urine obstruction, red leucorrhea, vaginal swelling and itching, eczema, eczema, skin itching, scabies, leprosy, and external treatment of trichomonas vaginitis.
  • the advantage of the present invention is that the hand sanitizer suitable for baby skin of the present invention is mainly composed of skin-friendly carbon molecular sieve suspension and natural plant essence, lauryl amidopropyl betaine, glycerin, sodium chloride, and glycerol , Coconut acid, citric acid and water.
  • the skin-friendly carbon molecular sieve suspension is sonicated from a carbon molecular sieve prepared from apple waste to obtain a filtrate containing micron-sized carbon molecular sieve, which is then mixed with the extracted traditional Chinese medicine concentrate and stirred at high speed; the skin-friendly carbon molecular sieve is suspended
  • the liquid not only has a good antibacterial effect of traditional Chinese medicine ingredients, but also compared to directly adding traditional Chinese medicine concentrates or traditional Chinese medicine extracts, the medicinal effects of various traditional Chinese medicine ingredients are also more likely to produce synergistic effects, effectively improving the sensitivity to sensitive skin and irritation Skin improvement effect; at the same time, because the carbon molecular sieve uses apple waste as raw material, it is not only healthy and environmentally friendly, but also harmless to the human body.
  • the carbon molecular sieve has a certain grinding effect on the skin, which is beneficial to exfoliating dead skin and improving dry skin.
  • the hand sanitizer of the present invention not only has a very good antibacterial effect and is non-irritating to infant skin, but also has a significant improvement effect on sensitive infant skin.
  • a preparation method of hand sanitizer suitable for baby skin includes the following steps:
  • the hand sanitizer suitable for baby skin consists of the following components by weight percentage: skin-friendly carbon molecular sieve suspension 7%, natural plant flavor 5%, lauramidopropyl betaine 3%, glycerin 6%, chlorinated Sodium 1.8%, glycerol 1.5%, coconut acid 5%, citric acid 3% and the balance of water.
  • the content of the carbon molecular sieve in the filtrate of the carbon-containing molecular sieve is 4%.
  • the weight ratio of the aloe, tuber long, pueraria lobata root, white fresh peel and sophora flavescens is 2:6:5:7:3.
  • the solid content of the concentrated liquid is 32%.
  • the mass ratio of the filtrate of the carbon-containing molecular sieve to the concentrated liquid is 100:1.5.
  • a preparation method of hand sanitizer suitable for baby skin includes the following steps:
  • the hand sanitizer suitable for baby skin consists of the following components by weight percentage: skin-friendly carbon molecular sieve suspension 5%, natural plant flavor 6%, lauramidopropyl betaine 2%, glycerin 10%, chlorinated Sodium 1.5%, glycerol 2%, coconut acid 3%, citric acid 4% and the balance of water.
  • the content of the carbon molecular sieve in the filtrate of the carbon-containing molecular sieve is 2%.
  • the weight ratio of the aloe vera, the tuber longum, the kudzu root, the white fresh peel and the sophora flavescens is 3:4:8:3:5.
  • the solid content of the concentrated solution is 20%.
  • the mass ratio of the filtrate of the carbon-containing molecular sieve to the concentrated liquid is 100:3.
  • a preparation method of hand sanitizer suitable for baby skin includes the following steps:
  • the hand sanitizer suitable for baby skin consists of the following components by weight percentage: skin-friendly carbon molecular sieve suspension 8%, natural plant flavor 3%, lauroamidopropyl betaine 4%, glycerin 4%, chlorinated Sodium 2.5%, glycerol 1.2%, coconut acid 6%, citric acid 2% and the balance of water.
  • the content of the carbon molecular sieve in the filtrate of the carbon-containing molecular sieve is 5%.
  • the weight ratio of the aloe vera, the long piper, the kudzu root, the white fresh peel and the sophora flavescens is 1:10:3:8:2.
  • the solid content of the concentrated liquid is 35%.
  • the mass ratio of the filtrate of the carbon-containing molecular sieve to the concentrated liquid is 100:0.5.
  • Step D in Example 1 is removed, and the filtrate and concentrated liquid of the carbon-containing molecular sieve are directly mixed with other raw materials at one time, and the remaining proportions and preparation methods are unchanged.
  • the hand sanitizers prepared in Examples 1-3 and Comparative Examples 1-3 and Comparative Examples 1-2 were tested for antibacterial activity as follows.
  • the specific test method is as follows: According to the provisions of the "Disinfection Technical Specifications" (2002 Edition) of the Ministry of Health of the People's Republic of China Bacillus (ATCC25922), Staphylococcus aureus (ATCC6538), Candida albicans (ATCC10231) antibacterial activity detection (action time 2min), specific test data see Table 1.
  • rabbit skin irritation tests were performed on the hand sanitizers prepared in Examples 1-3 and Comparative Examples 1-3 and Comparative Examples 1-2.
  • the specific test method is: at the same time, rabbits with healthy skin of 2.0-2.5Kg are selected (each The hand sanitizer of each example/comparative example/control example was tested on 3 rabbits, a total of 24 rabbits), the hair removal agent was used to remove about 3cm ⁇ 3cm of hair on both sides of the back spine of the rabbits without damaging the skin.
  • the hand sanitizers prepared in Examples 1-3, Comparative Examples 1-3, and Comparative Examples 1-2 were tested for the improvement of sensitive skin and irritated skin.
  • the test method is as follows: The tester uses the conventional method every morning, midnight, and night. Use 1 ml of the hand sanitizer sample of the present invention to clean the hand skin. Samples should not be changed during use, and skin health products such as prickly heat powder and toilet water are prohibited.
  • the degree of skin erythema improvement is measured by a spectrophotometer (Spectrophotometer-CM2600 Minolta, Japan), which reflects the saturation level of skin from red to green, and indirectly reflects the degree of skin erythema improvement;
  • Improvement of dry skin improvement of dry and chapped skin.
  • Table 2 Improvement test results of hand sanitizer for sensitive skin and irritated skin
  • the hand sanitizer of the present invention can effectively improve the sensitive skin and irritated skin of infants, and has a very good effect on improving dry skin.

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Abstract

一种适用于婴儿皮肤的洗手液，主要成分为亲肤碳分子筛悬浊液、天然植物香精、月桂酰胺丙基甜菜碱、甘油、氯化钠、丙三醇、椰油酸、柠檬酸和水。其中亲肤碳分子筛悬浊液由苹果废弃物制备的碳分子筛超声后得到含微米级碳分子筛的滤液，然后与提取的中药浓缩液混合后，高速搅拌，即可；该亲肤碳分子筛悬浊液不但具有中药成分良好的抗菌效果，而且相比于直接加入中药浓缩液或者中药提取物，各种中药成分的药效也更容易产生协同效果，有效提升了对敏感性皮肤和经刺激后的皮肤的改善效果；同时还可以改善皮肤干燥的情况。该洗手液不但抗菌效果非常好，对婴儿皮肤无刺激性，而且对敏感性婴儿皮肤还有显著的改善效果。

Description

一种适用于婴儿皮肤的洗手液的制备方法 技术领域
本发明涉及洗手液技术领域，尤其涉及一种适用于婴儿皮肤的洗手液的制备方法。
背景技术
洗手液是一种清洁手部为主的护肤清洁液，通过以机械摩擦和表面活性剂的作用，配合水流来清除手上的污垢和附着的细菌。
(1)洗手的目的就是要将手上的污渍和细菌去掉，因此洗净力是首先要考虑的，但洗净力和脱脂力是成正比的，优异的去污力伴随着强力的脱脂作用，应选择性能温和的无刺激的表面活性剂。
(2)丰富而持久的泡沫和易冲洗性，是洗手液产品质量的重要指标，泡沫丰富持久易冲洗，能带给使用者洗净手而没有负担的轻松体验，因此在配方设计中要重点考虑发泡和稳泡性能及易冲洗性。
(3)能够去除细菌，是洗手能达到真正洁净的关键，是作为洗手液主要应用于公众场合的原因。
传统的洗手液中的去污成分是为提供去污作用和丰富的泡沫，主要是阴离子表面活性剂以及少量的非离子和两性离子表面活性剂。阴离子表面活性剂有皂、十二烷基硫酸钠、Q一烯烃磺酸盐、脂肪醇聚氧乙烯醚硫酸盐、Q一磺基脂肪酸脂、月桂酰肌氨酸盐和单油酸酰胺磺基琥珀酸二钠等。皂和十二烷基硫酸钠是最早使用于洗手液的表面活性剂，由于他们各自的缺陷如较强的脱脂性，皂的高pH值及低的抗硬水性能形成的钙皂，已较少使用了。非离子表面活性剂一 般较少在洗手液中使用，少量的加入可以增进去污作用和提高泡沫的稳定性，如椰油酸二乙醇酰胺，其中烷基糖苷的加入可以降低表面活性剂的对皮肤的刺激。少量的两性离子加入有利于发泡和泡沫的持久，甜菜碱和氧化胺。
大多数洗手液中含有杀菌剂如碘化钾、纳米氧化银、三氯生，这些杀菌剂在使用过程中可能会引发儿童的不适感，对皮肤产生刺激，如果冲洗不干净，反而会给婴幼儿带来危害。
中国发明专利CN109199963A公开了一种婴幼儿专用草本洗手液及其制备方法，该产品以广盐链霉菌为发酵菌株，经活化后制成液态发酵种子，然后将蒲公英、金银花、梨果仙人掌、小蓟和水按重量为2∶1∶3∶1∶5的比例于混浆罐中混合，再经破壁、制浆、杀菌、冷却、接种液态发酵种子发酵、离心除杂、浓缩、提取后制成草本植物提取液，达到了无毒、无害，对皮肤刺激性小的技术效果。但是该草本植物提取液经过微生物发酵改性后，洗手液的抗菌效果不够理想，且该洗手液忽视了对敏感性婴儿皮肤的改善效果，故有必要研究一种适用于婴儿皮肤的洗手液。
发明内容
基于背景技术存在的技术问题，本发明提出了一种适用于婴儿皮肤的洗手液的制备方法。
本发明的技术方案如下：
一种适用于婴儿皮肤的洗手液的制备方法，包括以下步骤：
A、对苹果废弃物进行预处理，先经过简单的清洗后，将苹果废 弃物放入高速搅拌机中，加水搅拌均匀后，通过挤压、烘干、粉碎、球磨，将原材料制成干燥地粉末，过筛得到粒径为80-200μm的预处理的原材料；
B、将经过预处理的原材料放入碳化炉中，将原材料在平面上自然铺放3-5mm，将温度升至1100-1250℃，炭化得到碳分子筛炭素材料；将碳分子筛炭素材料采用5-12％的醋酸酸洗活化，然后再水洗至中性，然后在超声功率为1000-1200W，料液比为1∶(15-20)的条件下超声波粉碎10-15min后，过1250目筛，即得到含碳分子筛的滤液；
C、将按比例称取的芦荟、荜茇、葛根、白鲜皮、苦参，加入20-30倍的去离子水，回流提取2-3h，重复提取一次，合并两次提取液，浓缩得到浓缩液；
D、将含碳分子筛的滤液与浓缩液混合，6000-8000rpm高速搅拌5-8min，得到亲肤碳分子筛悬浊液；
E、将亲肤碳分子筛悬浊液与天然植物香精、月桂酰胺丙基甜菜碱、甘油、氯化钠、丙三醇、椰油酸、柠檬酸和水按比例混合，搅拌均匀，即可得到适用于婴儿皮肤的洗手液。
优选的，所述的适用于婴儿皮肤的洗手液，由以下重量百分比的成分组成：亲肤碳分子筛悬浊液3-10％、天然植物香精2-10％、月桂酰胺丙基甜菜碱1-5％、甘油2-12％、氯化钠1-3％、丙三醇0.8-2.5％、椰油酸1-8％、柠檬酸1-5％和水余量。
进一步优选的，所述的适用于婴儿皮肤的洗手液，由以下重量百分比的成分组成：亲肤碳分子筛悬浊液5-8％、天然植物香精3-6％、 月桂酰胺丙基甜菜碱2-4％、甘油4-10％、氯化钠1.5-2.5％、丙三醇1.2-2％、椰油酸3-6％、柠檬酸2-4％和水余量。
优选的，所述的步骤B中，所述的含碳分子筛的滤液中，碳分子筛的含量为2-5％。
优选的，所述的步骤C中，所述的芦荟、荜茇、葛根、白鲜皮和苦参的重量份比例为(1-3)∶(4-10)∶(3-8)∶(3-8)∶(2-5)。
优选的，所述的步骤C中，所述的浓缩液的固含量为20-35％。
优选的，所述的步骤D中，所述的含碳分子筛的滤液与浓缩液的质量比为100∶(0.5-3)。
芦荟(即库拉索芦荟)是芦荟属中少数可食用的物种之一，其制品被广泛应用于食品、美容、保健、医药等领域。芦荟中含的多糖和多种维生素对人体皮肤有良好的营养、滋润、增白作用。它具有使皮肤收敛、柔软化、保湿、消炎、漂白的性能。还有解除硬化、角化、改善伤痕的作用，不仅能防止小皱纹、眼袋、皮肤松弛，还能保持皮肤湿润、娇嫩，同时，还可以治疗皮肤炎症，对粉刺、雀斑、痤疮以及烫伤、刀伤、虫咬等亦有很好的疗效。
荜拨，别名：毕勃、荜茇、荜菝、荜拨胡椒科，胡椒属。攀援藤本，长达数米；枝有粗纵棱和沟槽，幼时被极细的粉状短柔毛，毛很快脱落。茎细如箸，叶似蕺叶，子似桑椹，八月采，果穗可入药。产于云南东南至西南部，广西、广东和福建有栽培。荜茇果穗圆柱形，表面黑褐果聚成，断面微红香特异，温中下气呕痛宁。味辛，性温和，无毒。一般用于治疗五劳七伤，冷气呕吐，心腹胀满，消化不良， 阴汗疝嵌水肿，妇人宫寒不孕。本发明中加入荜拨有利于提升对敏感性皮肤和经刺激后皮肤的改善效果
葛根，中药名。为豆科植物野葛的干燥根，习称野葛。秋、冬二季采挖，趁鲜切成厚片或小块；干燥。甘、辛，凉。有解肌退热，透疹，生津止渴，升阳止泻之功。常用于表证发热，项背强痛，麻疹不透，热病口渴，阴虚消渴，热泻热痢，脾虚泄泻。
白鲜皮，别名：白藓皮、八股牛、山牡丹、羊鲜草，拉丁文名：CORTEX DICTAMNI中药名。为芸香科多年生草本植物白鲜和狭叶白鲜的根皮。主产于辽宁、河北、四川、江苏等地。春、秋二季采挖根部，除去泥沙及粗皮，剥取根皮，切片，干燥。生用。具有清热燥湿，祛风解毒之功效。
苦参，中药名。为豆科植物苦参的干燥根，春、秋二季采挖，除去根头和小支根，洗净，干燥，或趁鲜切片，干燥。其苦，寒。有清热燥湿，杀虫，利尿之功。用于热痢，便血，黄疸尿闭，赤白带下，阴肿阴痒，湿疹，湿疮，皮肤瘙痒，疥癣麻风，外治滴虫性阴道炎。
本发明的有益之处在于：本发明的适用于婴儿皮肤的洗手液，主要成分为亲肤碳分子筛悬浊液与天然植物香精、月桂酰胺丙基甜菜碱、甘油、氯化钠、丙三醇、椰油酸、柠檬酸和水。其中亲肤碳分子筛悬浊液由苹果废弃物制备的碳分子筛超声后得到含微米级碳分子筛的滤液，然后与提取的中药浓缩液混合后，高速搅拌，即可；该亲肤碳分子筛悬浊液不但具有中药成分良好的抗菌效果，而且相比于直接加入中药浓缩液或者中药提取物，各种中药成分的药效也更容易产 生协同效果，有效提升了对敏感性皮肤和经刺激后的皮肤的改善效果；同时由于该碳分子筛采用苹果废弃物为原料，不但健康环保，而且对人体无害，且碳分子筛对皮肤还有一定的研磨作用，有利于去死皮，改善皮肤干燥的情况。本发明的洗手液，不但抗菌效果非常好，对婴儿皮肤无刺激性，而且对敏感性婴儿皮肤还有显著的改善效果。
具体实施方式
实施例1
一种适用于婴儿皮肤的洗手液的制备方法，包括以下步骤：
A、对苹果废弃物进行预处理，先经过简单的清洗后，将苹果废弃物放入高速搅拌机中，加水搅拌均匀后，通过挤压、烘干、粉碎、球磨，将原材料制成干燥地粉末，过筛得到粒径为80-200μm的预处理的原材料；
B、将经过预处理的原材料放入碳化炉中，将原材料在平面上自然铺放3-5mm，将温度升至1180℃，炭化得到碳分子筛炭素材料；将碳分子筛炭素材料采用质量分数为8.5％的醋酸酸洗活化，然后再水洗至中性，然后在超声功率为1050W，料液比为1∶18的条件下超声波粉碎12min后，过1250目筛，即得到含碳分子筛的滤液；
C、将按比例称取的芦荟、荜茇、葛根、白鲜皮、苦参，加入25倍的去离子水，回流提取2h，重复提取一次，合并两次提取液，浓缩得到浓缩液；
D、将含碳分子筛的滤液与浓缩液混合，7500rpm高速搅拌6min，得到亲肤碳分子筛悬浊液；
E、将亲肤碳分子筛悬浊液与天然植物香精、月桂酰胺丙基甜菜碱、甘油、氯化钠、丙三醇、椰油酸、柠檬酸和水按比例混合，搅拌均匀，即可得到适用于婴儿皮肤的洗手液。
所述的适用于婴儿皮肤的洗手液，由以下重量百分比的成分组成：亲肤碳分子筛悬浊液7％、天然植物香精5％、月桂酰胺丙基甜菜碱3％、甘油6％、氯化钠1.8％、丙三醇1.5％、椰油酸5％、柠檬酸3％和水余量。
所述的步骤B中，所述的含碳分子筛的滤液中，碳分子筛的含量为4％。
所述的步骤C中，所述的芦荟、荜茇、葛根、白鲜皮和苦参的重量份比例为2∶6∶5∶7∶3。
所述的步骤C中，所述的浓缩液的固含量为32％。
所述的步骤D中，所述的含碳分子筛的滤液与浓缩液的质量比为100∶1.5。
实施例2
一种适用于婴儿皮肤的洗手液的制备方法，包括以下步骤：
A、对苹果废弃物进行预处理，先经过简单的清洗后，将苹果废弃物放入高速搅拌机中，加水搅拌均匀后，通过挤压、烘干、粉碎、球磨，将原材料制成干燥地粉末，过筛得到粒径为80-200μm的预处理的原材料；
B、将经过预处理的原材料放入碳化炉中，将原材料在平面上自然铺放3-5mm，将温度升至1250℃，炭化得到碳分子筛炭素材料； 将碳分子筛炭素材料采用质量分数为5％的醋酸酸洗活化，然后再水洗至中性，然后在超声功率为1200W，料液比为1∶15的条件下超声波粉碎15min后，过1250目筛，即得到含碳分子筛的滤液；
C、将按比例称取的芦荟、荜茇、葛根、白鲜皮、苦参，加入20倍的去离子水，回流提取3h，重复提取一次，合并两次提取液，浓缩得到浓缩液；
D、将含碳分子筛的滤液与浓缩液混合，6000rpm高速搅拌8min，得到亲肤碳分子筛悬浊液；
E、将亲肤碳分子筛悬浊液与天然植物香精、月桂酰胺丙基甜菜碱、甘油、氯化钠、丙三醇、椰油酸、柠檬酸和水按比例混合，搅拌均匀，即可得到适用于婴儿皮肤的洗手液。
所述的适用于婴儿皮肤的洗手液，由以下重量百分比的成分组成：亲肤碳分子筛悬浊液5％、天然植物香精6％、月桂酰胺丙基甜菜碱2％、甘油10％、氯化钠1.5％、丙三醇2％、椰油酸3％、柠檬酸4％和水余量。
所述的步骤B中，所述的含碳分子筛的滤液中，碳分子筛的含量为2％。
所述的步骤C中，所述的芦荟、荜茇、葛根、白鲜皮和苦参的重量份比例为3∶4∶8∶3∶5。
所述的步骤C中，所述的浓缩液的固含量为20％。
所述的步骤D中，所述的含碳分子筛的滤液与浓缩液的质量比为100∶3。
实施例3
一种适用于婴儿皮肤的洗手液的制备方法，包括以下步骤：
A、对苹果废弃物进行预处理，先经过简单的清洗后，将苹果废弃物放入高速搅拌机中，加水搅拌均匀后，通过挤压、烘干、粉碎、球磨，将原材料制成干燥地粉末，过筛得到粒径为80-200μm的预处理的原材料；
B、将经过预处理的原材料放入碳化炉中，将原材料在平面上自然铺放3-5mm，将温度升至1100℃，炭化得到碳分子筛炭素材料；将碳分子筛炭素材料采用12％的醋酸酸洗活化，然后再水洗至中性，然后在超声功率为1000W，料液比为1∶20的条件下超声波粉碎10min后，过1250目筛，即得到含碳分子筛的滤液；
C、将按比例称取的芦荟、荜茇、葛根、白鲜皮、苦参，加30倍的去离子水，回流提取2h，重复提取一次，合并两次提取液，浓缩得到浓缩液；
D、将含碳分子筛的滤液与浓缩液混合，8000rpm高速搅拌5min，得到亲肤碳分子筛悬浊液；
E、将亲肤碳分子筛悬浊液与天然植物香精、月桂酰胺丙基甜菜碱、甘油、氯化钠、丙三醇、椰油酸、柠檬酸和水按比例混合，搅拌均匀，即可得到适用于婴儿皮肤的洗手液。
所述的适用于婴儿皮肤的洗手液，由以下重量百分比的成分组成：亲肤碳分子筛悬浊液8％、天然植物香精3％、月桂酰胺丙基甜菜碱4％、甘油4％、氯化钠2.5％、丙三醇1.2％、椰油酸6％、柠檬酸2％ 和水余量。
所述的步骤B中，所述的含碳分子筛的滤液中，碳分子筛的含量为5％。
所述的步骤C中，所述的芦荟、荜茇、葛根、白鲜皮和苦参的重量份比例为1∶10∶3∶8∶2。
所述的步骤C中，所述的浓缩液的固含量为35％。
所述的步骤D中，所述的含碳分子筛的滤液与浓缩液的质量比为100∶0.5。
对比例1
将实施例1中的含碳分子筛的滤液去除，直接将同等比例的浓缩液与其它原料混合，其余配比和制备方法不变。
对比例2
将实施例1中的步骤D去除，直接将含碳分子筛的滤液、浓缩液与其它原料一次性混合，其余配比和制备方法不变。
对比例3
将实施例1中的含浓缩液中的中药荜茇去除，其余配比和制备方法不变。
对照例1
中国发明专利CN109199963A实施例1制备的洗手液。
对照例2
中国发明专利CN105078828A实施例1制备的洗手液。
测试1
以下对实施例1-3和对比例1-3以及对照例1-2制备的洗手液进行抗菌测试，具体测试方法为：根据中华人民共和国卫生部《消毒技术规范》(2002年版)规定对大肠杆菌(ATCC25922)、金葡萄球菌(ATCC6538)、白色念珠菌(ATCC10231)抑菌活性检测(作用时间2min)，具体测试数据见表1。
表1：洗手液抗菌测试结果；
抑菌率％ 白色念珠菌 金黄色葡萄球菌 大肠杆菌
实施例1 96.7 99.5 97.3
实施例2 96.9 99.6 97.5
实施例3 96.6 99.3 97.1
对比例1 91.2 95.4 92.0
对比例2 92.5 96.1 92.7
对比例3 93.4 95.9 93.7
对照例1 91.4 99.1 98.8
对照例2 97.2 96.4 54.7
由以上测试数据可以知道，本发明实施例1-3制备的洗手液具有非常好的抗菌、抑菌效果。
测试2
以下对实施例1-3和对比例1-3以及对照例1-2制备的洗手液进行家兔皮肤刺激性测试，具体测试方法为：同时选择2.0-2.5Kg健康皮肤完好的家兔(每个实施例/对比例/对照例的洗手液测试3只家兔，合计24只家兔)，使用脱毛剂将家兔背部脊柱两侧面积约 3cm×3cm的毛去除，不损伤皮肤。使用棉签沾取本洗手液涂于家兔一侧的脱毛皮肤处，4h后用温水洗去残留液；该家兔脱毛皮肤的另一侧作为空白对照，每天涂抹一次，连续涂抹14d。每次涂抹24h后观察。
结果显示，24只家兔涂抹皮肤处均无红肿、发炎、溃烂等现象，与对照皮肤无差别，表明测试的洗手液均对皮肤无刺激性。
测试3
以下对实施例1-3和对比例1-3以及对照例1-2制备的洗手液进行敏感性皮肤和经刺激后皮肤的改善测试，测试方法如下：测试者每日早中晚按常规方法使用本发明的洗手液样品1ml清洁手部皮肤。使用期间不得更换样品，且禁止使用如痱子粉、花露水等皮肤保健产品。
衡量标准：
1、皮肤红斑改善程度；由分光测色计(Spectrophotometer-CM2600 Minolta，日本)测定皮肤α值，该值反映皮肤红色到绿色的饱和水平，间接反映皮肤红斑改善程度；
2、经刺激后皮肤改善：测试者靶部位原症状是否改善或出现新的皮损，如脱屑、红肿、脱屑等症状；
3、皮肤干燥改善：皮肤干燥皲裂程度改善情况。
200名敏感性肌肤测试者(经刺激性测试确定)，年龄范围：6-12个月，分为8组，每组25名测试者，各组之间无显著性差异。每天早中晚各使用一次洗手液样品，连续使用30天。测试结果如表2所示。
表2：洗手液敏感性皮肤和经刺激后皮肤的改善测试结果；
Figure PCTCN2020119025-appb-000001
由以上测试数据可以知道，本发明的洗手液可以有效改善婴儿敏感性皮肤和经刺激后的皮肤，对皮肤干燥改善效果也非常好。
以上所述，仅为本发明较佳的具体实施方式，但本发明的保护范围并不局限于此，任何熟悉本技术领域的技术人员在本发明揭露的技术范围内，根据本发明的技术方案及其发明构思加以等同替换或改变，都应涵盖在本发明的保护范围之内。

Claims (7)

  1. 一种适用于婴儿皮肤的洗手液的制备方法，其特征在于，包括以下步骤：
    A、对苹果废弃物进行预处理，先经过简单的清洗后，将苹果废弃物放入高速搅拌机中，加水搅拌均匀后，通过挤压、烘干、粉碎、球磨，将原材料制成干燥地粉末，过筛得到粒径为80-200μm的预处理的原材料；
    B、将经过预处理的原材料放入碳化炉中，将原材料在平面上自然铺放3-5mm，将温度升至1100-1250℃，炭化得到碳分子筛炭素材料；将碳分子筛炭素材料采用5-12％的醋酸酸洗活化，然后再水洗至中性，然后在超声功率为1000-1200W，料液比为1∶(15-20)的条件下超声波粉碎10-15min后，过1250目筛，即得到含碳分子筛的滤液；
    C、将按比例称取的芦荟、荜茇、葛根、白鲜皮、苦参，加入20-30倍的去离子水，回流提取2-3h，重复提取一次，合并两次提取液，浓缩得到浓缩液；
    D、将含碳分子筛的滤液与浓缩液混合，6000-8000rpm高速搅拌5-8min，得到亲肤碳分子筛悬浊液；
    E、将亲肤碳分子筛悬浊液与天然植物香精、月桂酰胺丙基甜菜碱、甘油、氯化钠、丙三醇、椰油酸、柠檬酸和水按比例混合，搅拌均匀，即可得到适用于婴儿皮肤的洗手液。
  2. 如权利要求1所述的适用于婴儿皮肤的洗手液的制备方法，其特征在于，所述的适用于婴儿皮肤的洗手液，由以下重量百分比的成分组成：亲肤碳分子筛悬浊液3-10％、天然植物香精2-10％、月桂酰胺丙基甜菜碱1-5％、甘油212％、氯化钠1-3％、丙三醇0.8-2.5％、椰油酸1-8％、柠檬酸15％和水余量。
  3. 如权利要求1所述的适用于婴儿皮肤的洗手液的制备方法，其特征在于，所述的适用于婴儿皮肤的洗手液，由以下重量百分比的成分组成：亲肤碳分子 筛悬浊液5-8％、天然植物香精36％、月桂酰胺丙基甜菜碱2-4％、甘油410％、氯化钠1.5-2.5％、丙三醇1.2-2％、椰油酸3-6％、柠檬酸2-4％和水余量。
  4. 如权利要求1所述的适用于婴儿皮肤的洗手液的制备方法，其特征在于，所述的步骤B中，所述的含碳分子筛的滤液中，碳分子筛的含量为2-5％。
  5. 如权利要求1所述的适用于婴儿皮肤的洗手液的制备方法，其特征在于，所述的步骤C中，所述的芦荟、荜茇、葛根、白鲜皮和苦参的重量份比例为(1-3)∶(4-10)∶(3-8)∶(3-8)∶(2-5)。
  6. 如权利要求1所述的适用于婴儿皮肤的洗手液的制备方法，其特征在于，所述的步骤C中，所述的浓缩液的固含量为20-35％。
  7. 如权利要求1所述的适用于婴儿皮肤的洗手液的制备方法，其特征在于，所述的步骤D中，所述的含碳分子筛的滤液与浓缩液的质量比为100∶(0.5-3)。
PCT/CN2020/119025 2020-01-13 2020-09-29 一种适用于婴儿皮肤的洗手液的制备方法 WO2021143209A1 (zh)

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