WO2021135368A1 - 样本处理方法和装置 - Google Patents

样本处理方法和装置 Download PDF

Info

Publication number
WO2021135368A1
WO2021135368A1 PCT/CN2020/114209 CN2020114209W WO2021135368A1 WO 2021135368 A1 WO2021135368 A1 WO 2021135368A1 CN 2020114209 W CN2020114209 W CN 2020114209W WO 2021135368 A1 WO2021135368 A1 WO 2021135368A1
Authority
WO
WIPO (PCT)
Prior art keywords
sample
target
reagent
information
processed
Prior art date
Application number
PCT/CN2020/114209
Other languages
English (en)
French (fr)
Inventor
张晶鑫
吴栋杨
李临
Original Assignee
科美诊断技术股份有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 科美诊断技术股份有限公司 filed Critical 科美诊断技术股份有限公司
Publication of WO2021135368A1 publication Critical patent/WO2021135368A1/zh

Links

Images

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00584Control arrangements for automatic analysers
    • G01N35/00594Quality control, including calibration or testing of components of the analyser
    • G01N35/00613Quality control
    • G01N35/00663Quality control of consumables
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00584Control arrangements for automatic analysers
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N2035/00346Heating or cooling arrangements
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00584Control arrangements for automatic analysers
    • G01N35/00594Quality control, including calibration or testing of components of the analyser
    • G01N35/00613Quality control
    • G01N35/00663Quality control of consumables
    • G01N2035/00673Quality control of consumables of reagents

Definitions

  • the present invention relates to the technical field of sample processing, in particular to a sample processing method and device.
  • both the medical field and the chemical experiment field involve the incubation of samples.
  • the present invention provides a sample processing method and device to solve the problems of poor operational flexibility, low accuracy, and poor intelligence existing in artificially incubating samples in related technologies.
  • the present invention discloses a sample processing method, which is applied to a diagnostic device or a terminal connected to the diagnostic device, and the method includes:
  • target sample information Acquiring, according to the target sample information, target reagent information of a target reagent matching the sample to be processed;
  • the sample to be processed is processed.
  • the present invention also discloses a sample processing device, which is applied to a diagnostic equipment or a terminal connected to the diagnostic equipment, and the device includes:
  • the first obtaining module is used to obtain target sample information of the sample to be processed set in the target area
  • the second acquiring module is configured to acquire the target reagent information of the target reagent matching the sample to be processed according to the target sample information;
  • the processing module is configured to process the sample to be processed according to the target reagent information.
  • the present invention includes the following advantages:
  • the target reagent information of the target reagent matching the sample to be processed can be obtained according to the target sample information of the sample to be processed in the target area; and the target reagent information is processed according to the target reagent information. sample.
  • the automatic incubation of the sample is realized, and the reagent information of the target reagent used for incubating the sample is suitable for the incubation of the sample to be processed, thereby improving the accuracy of the sample incubation and avoiding the artificial incubation of the sample.
  • the method of the embodiment of the present invention improves the flexibility, accuracy, and intelligence of incubating samples.
  • FIG. 1 is a flowchart of steps of an embodiment of a sample processing method of the present invention
  • FIG. 2 is a flowchart of steps of another embodiment of a sample processing method of the present invention.
  • Fig. 3 is a structural block diagram of an embodiment of a sample processing device of the present invention.
  • Fig. 4 schematically shows a block diagram of a computing processing device for executing the method according to the present invention.
  • Fig. 5 schematically shows a storage unit for holding or carrying program codes for implementing the method according to the present invention.
  • the various embodiments of the present invention can be applied to a diagnostic device or a terminal connected to the diagnostic device.
  • the diagnostic equipment may be equipment used for medical diagnosis or inspection.
  • the diagnostic equipment includes but not limited to: biochemical analyzer, chemiluminescence immunoassay analyzer, fluorescence immunoassay analyzer, immunoturbidimetric analyzer, biochemical immune integrated machine, and gene Sequencer.
  • the present invention uses a fully automatic photo-induced chemiluminescence detector to describe this embodiment in detail.
  • a step flow chart of an embodiment of a sample processing method of the present invention can be applied to a fully automatic photoinduced chemiluminescence detector.
  • the method can specifically include the following steps:
  • Step 101 Obtain target sample information of a sample to be processed set in a target area
  • the target area may be an incubation area
  • the incubation area is used to incubate the sample to be processed, that is, when it is necessary to incubate the sample, the method of the embodiment of the present invention can combine the sample to be incubated (ie, the sample to be incubated). Treat the sample) into the incubation area.
  • one incubation zone can incubate one or more samples to be incubated. Therefore, the number of samples to be processed in this step can be one or more.
  • the sample to be incubated is used to describe the sample to be processed, and the incubation area is used to describe the target area.
  • the target sample information of the sample to be incubated in the incubation area can be obtained.
  • the target sample information may include attributes of the sample, such as sample name, sample composition, and so on.
  • each sample to be incubated can be added with a target reagent for incubating the sample.
  • the target reagents corresponding to different samples to be incubated can be the same or different.
  • the target reagent may include at least one reagent.
  • the method of the embodiment of the present invention can be applied to a general fluid management process of an in vitro diagnostic device.
  • Step 102 Obtain target reagent information of a target reagent matching the sample to be processed according to the target sample information;
  • Step 103 Process the sample to be processed according to the target reagent information.
  • the target reagent information of the target reagent matching the sample to be processed can be obtained according to the target sample information of the sample to be processed in the target area; and the target reagent information is processed according to the target reagent information. sample.
  • the automatic incubation of the sample is realized, and the reagent information of the target reagent used for incubating the sample is suitable for the incubation of the sample to be processed, thereby improving the accuracy of the sample incubation and avoiding the artificial incubation of the sample.
  • the method of the embodiment of the present invention improves the flexibility, accuracy, and intelligence of incubating samples.
  • step 103 when step 103 is performed, the processing temperature and processing duration in the target area can be controlled; the status information of the sample to be processed is recorded within the processing duration; and a processing report is generated according to the status information.
  • the method of the embodiment of the present invention can control the temperature in the incubation zone, and control the incubation time (that is, the processing time) of the sample to be incubated in the incubation zone; and can be within the incubation time , Record the status information of the sample to be incubated in real time; according to the recorded status information of the sample to be incubated, a work report (ie processing report) of the sample to be incubated is formed.
  • the processing report may be a document.
  • the temperature of the incubation and the duration of the incubation can be controlled, and during the incubation process, the to-be-processed sample in the target area is recorded in real time.
  • the status information of the sample is thus based on the status information to form a processing report, which can be understood as the processing result of the sample to be processed, so that the incubation result is clearly visible and facilitates the traceability of various information.
  • step flow chart of another embodiment of a sample processing method of the present invention, which is applied to a diagnostic device or a terminal connected to the diagnostic device.
  • the method may specifically include the following steps:
  • step 201 detecting whether there is a sample to be processed in the target area
  • sample to be processed such as a sample to be incubated
  • target area such as an incubation area
  • a prompt message for adding a sample to be processed is output. That is, if there is no sample to be incubated in the incubation area, a prompt message is output to prompt the user to add the sample to be incubated in the incubation area.
  • step 202 If yes, go to step 202 to obtain target sample information of the sample to be processed;
  • the target sample information (including sample attribute information such as sample name, sample composition, etc.) of each sample to be incubated in the incubation area can be obtained;
  • step 206 the reagent information of the third reagent added in the sample to be processed is obtained;
  • the third reagent that has been added to the sample to be incubated can be determined.
  • the acquired reagent information of the third reagent that has been added to each sample to be incubated may include, for example, reagent attribute information such as reagent name, reagent composition, and reagent dosage.
  • the third reagent added to each sample to be incubated may be the same or different.
  • Step 203 According to the preset first correspondence between the sample information and the first reagent information, query the first target reagent information of the first target reagent that matches the target sample information;
  • the reagent information (ie, reagent attribute information) of the reagent used to cultivate the sample can be configured for each sample. Therefore, preset sample information (sample attribute information) can be generated in advance. , Such as the name of the sample, etc.) and the first corresponding relationship between the first reagent information (attribute information of the reagent, such as the name of the reagent, etc.), then in this step, the first corresponding relationship can be inquired to determine the match with the target sample information The first target reagent information of the first target reagent.
  • the first corresponding relationship may be the corresponding relationship between the sample name and the reagent name, the corresponding relationship between the sample components and the reagent components, the sample dose and the reagent Correspondence between doses, at least one of the three types of correspondence.
  • step 204 is to generate a message confirming that the third reagent is suitable for processing the sample to be processed.
  • the first target reagent information queried from the first correspondence relationship is exactly the reagent information of the third reagent that has been added to the sample to be incubated (for example, the reagent name and the amount of reagent in the first target reagent information) And other necessary incubation parameters, which are the same as the reagent name and reagent quantity of the third reagent), it means that the third reagent added to the sample to be incubated in the incubation area matches the sample to be incubated, that is, the The third reagent can be used to accurately incubate the sample to be incubated, so a message can be generated, which indicates that the third reagent is suitable for processing the sample to be processed.
  • the preset first correspondence between the sample information and the first reagent information can be used to determine whether the third reagent added to the sample to be processed in the target area matches the sample to be processed. That is, whether the third reagent can be used to accurately incubate the sample to be processed, so as to avoid sample incubation failure caused by incorrect addition of reagents, and improve the accuracy of sample incubation.
  • the third reagent may be used to process the sample to be processed according to the received incubation information.
  • the incubation information may include, but is not limited to, the target treatment temperature and the target treatment time in the target area, so that the incubation temperature in the target area can be controlled as the target treatment temperature, and the incubation time can be controlled as
  • the third reagent is used to incubate the sample to be processed, and the status information of the sample to be processed is recorded during the incubation duration; a processing report is generated according to the status information.
  • step 214 is output indicating that the third reagent added to the sample to be processed does not It is suitable for processing the message of the sample to be processed and controlling the transfer device to move the sample to be processed in the target area out of the target area.
  • the transfer device is a device of the sample processing device, and the transfer device is used to move samples, reagents, general solutions, etc. to be processed.
  • the specific structure of the transfer device is not limited, and can be any known or future-developed device for moving samples, reagents and solutions.
  • the diagnostic equipment may include the transfer device.
  • step 204 in another embodiment, as shown in FIG. 2, the message confirming that the third reagent is suitable for processing the sample to be processed generated in step 204 can be transferred to the step 205.
  • Software module in another embodiment, as shown in FIG. 2, the message confirming that the third reagent is suitable for processing the sample to be processed generated in step 204 can be transferred to the step 205.
  • the method may further include step 205, if a message for confirming that the third reagent is suitable for processing the sample to be processed is received (indicating that the to-be-processed sample in the target area is The third reagent that has been added to the sample has the first target reagent information), and according to the preset second correspondence between the sample information and the second reagent information, it is identified that matches the target sample information of the sample to be processed The second target reagent information;
  • the reagent with the second reagent information in the second correspondence relationship can be called a universal solution, which is also a kind of reagent liquid. Since the reagent liquid can be commonly used in multiple reagent incubation items, the reagent liquid can be called General solution; In addition, the general solution participates in the detection process as a reagent component during the sample detection process.
  • the third reagent added to each group of samples to be incubated in the incubation area matches the corresponding sample to be incubated, it means that the third reagent in each group of samples to be incubated is The addition is accurate, that is, the added third reagent can indeed be used to incubate the sample to be incubated.
  • the target sample information of each sample to be incubated in the incubation area matches each target universal solution (that is, each second target reagent information). That is, the corresponding target general solution can be found according to the sample to be incubated.
  • the second reagent information of the second reagent used to cultivate the sample can be configured for each sample according to the incubation requirements of each sample to be incubated. Therefore, sample information (attribute information of the sample) can be generated in advance. , Such as the sample name, composition, dosage, etc.) and the second reagent information (attribute information of the general solution, such as the name, composition, dosage, etc. of the general solution), then in this step, you can query the second The corresponding relationship can identify the second target reagent information (that is, the attribute information of the target general solution) that matches the target sample information (that is, the attribute information of the sample to be incubated).
  • the second correspondence may be the correspondence between the sample name and the reagent name, the correspondence between the sample components and the reagent components, the sample dose and the reagent Correspondence between doses, at least one of the three types of correspondence.
  • Step 207 Inquire whether there is a second target reagent having the information of the second target reagent among the plurality of second reagents respectively set in the plurality of candidate regions.
  • the second reagent can be set in the candidate area, and different kinds of second reagents can be set in different candidate areas. Therefore, in this step, it is possible to query whether the second reagent is set in multiple candidate areas. There is the second target reagent required for the sample to be incubated.
  • the attribute information (for example, including attribute information such as the name, composition, and remaining amount of the second reagent) of a plurality of second reagents set in a plurality of candidate regions can be obtained, and then the attribute information can be used to determine the Whether there is a second target reagent with second target reagent information (for example, the name and composition of the second reagent) in each candidate region.
  • second target reagent information for example, the name and composition of the second reagent
  • step 208 Controlling the suction device to suck the second target reagent from the target candidate area where the second target reagent is set;
  • the suction device is controlled to remove the target reagent from the target.
  • the second target reagent is sucked from the candidate area.
  • the correspondence between the number of the candidate area and the identifier of the second reagent may be generated in advance, Then, by querying the corresponding relationship, the target number of the candidate region matched with the identifier of the second target reagent can be obtained, so that the second reagent set in the target candidate region with the target number is identified as the second target reagent.
  • the diagnostic equipment may include the suction device.
  • the suction device is a device used to suck reagents and other liquids and add the sucked liquid to the sample to be processed.
  • the specific structure of the suction device is not limited in the present invention, and the prior art can be referred to.
  • the suction device can be controlled to suck the second target reagent from the target candidate area, and add the sucked second target reagent to the sample to be incubated in the incubation area, so that not only the third reagent is added to the sample to be incubated , And the second target reagent is also added.
  • Step 209 Add the sucked second target reagent to the sample to be processed in the target area, and process the sample to be processed.
  • the preset second correspondence between the sample information and the second reagent information can be used to determine whether there is a second reagent matching the sample to be processed among the multiple second reagents in the multiple candidate regions.
  • Second target reagent if it exists, the second target reagent set in the target candidate area can be used to accurately incubate the sample to be processed, so as to avoid sample incubation failure caused by incorrect addition of common solution The situation has improved the accuracy of sample incubation.
  • the suction device is controlled to remove the second target reagent from the target candidate area provided with the second target reagent.
  • the second target reagent is absorbed in the target area and added to the sample to be processed in the target area, so that when the sample to be processed is incubated, the added target reagent (in the case of the second target reagent, or in the case of the second target reagent and the third reagent) ) Are matched with the sample to be processed to ensure the accurate incubation of the sample; and, before adding the second target reagent, it can be determined whether the remaining amount of the second target reagent meets the preset condition, thereby avoiding the second target reagent When the remaining amount of the sample is insufficient, the incubation failure of the sample is treated.
  • the above process realizes the automatic incubation of the sample and avoids the problems of poor operational flexibility, low accuracy and poor intelligence in the artificial incubation of the sample.
  • the present invention The method of the embodiment improves the flexibility, accuracy, and intelligence of incubating samples.
  • step 215 output a prompt message indicating that the remaining amount of the second target reagent is insufficient, and stop processing the sample to be processed in the target area.
  • output prompt information indicating that the remaining amount of the second target reagent in the target candidate area is insufficient, so that the user can continue to inject the solution into the second target reagent in the target candidate area; at the same time, the method of the embodiment of the present invention will also stop The samples to be incubated in the incubation area are incubated.
  • the remaining amount of the second target reagent meets a preset condition, if the remaining amount of the second target reagent is greater than a first preset threshold, determine the remaining amount of the second target reagent The preset conditions are met; otherwise, the preset conditions are not met.
  • the first preset threshold indicates that the remaining amount of the second target reagent can meet the incubation requirement of the sample to be incubated, therefore, it is determined that the remaining amount of the second target reagent meets the preset condition.
  • the amount of the second target reagent added is set in advance by the system, and when the second target reagent is obtained, it is judged whether the remaining amount is greater than the required amount, and if so, the liquid can be taken.
  • the remaining amount of the second target reagent when the remaining amount of the second target reagent is greater than the first preset threshold, it may be determined that the remaining amount of the second target reagent solution can meet the processing requirements of the sample to be processed, so as to avoid the problem of the second target reagent.
  • the incubation failure of the sample to be processed caused by the insufficient dose.
  • the processing temperature and processing time in the target area can be controlled, and the status information of the sample to be processed can be recorded during the processing time, and finally To generate a processing report according to the status information.
  • the sample when incubating the sample, can be incubated with the third reagent, or the sample can be incubated with the second target reagent, or the sample can be incubated with the third reagent and the second target reagent.
  • the third reagent added to the sample to be processed matches the sample to be processed.
  • the second reagent that matches the sample to be processed can be identified. Two target reagents, and determine whether the second target reagent exists in a plurality of candidate regions.
  • the suction device can be controlled to The second target reagent is sucked from the target candidate area provided with the second target reagent and added to the sample to be processed in the target area, so that when the sample to be processed is incubated, the added third reagent and the second target reagent are both the same
  • the sample to be processed is matched, and it can be determined whether the remaining amount of the second target reagent meets the preset condition before adding the second target reagent, thereby avoiding the temperature of the sample to be processed when the remaining amount of the second target reagent is insufficient.
  • the above process realizes the automatic incubation of the sample, and avoids the problems of poor operational flexibility, low accuracy, and poor intelligence in the artificial incubation of the sample.
  • the method of the embodiment of the present invention improves the incubation of the sample. Flexibility, accuracy, and intelligence.
  • FIG. 3 a structural block diagram of an embodiment of a sample processing apparatus of the present invention is shown, which is applied to diagnostic equipment or a terminal connected to the diagnostic equipment.
  • the apparatus may specifically include The following modules:
  • the first obtaining module 31 is configured to obtain target sample information of the sample to be processed set in the target area;
  • the second obtaining module 32 is configured to obtain target reagent information of a target reagent matching the sample to be processed according to the target sample information;
  • the processing module 33 is configured to process the sample to be processed according to the target reagent information.
  • the second obtaining module 32 includes:
  • the first query submodule is configured to query the first target reagent information of the first target reagent that matches the target sample information according to the preset first correspondence between the sample information and the first reagent information;
  • the processing module 33 includes:
  • the first generation sub-module is configured to generate and confirm that the third reagent is suitable for processing the to-be-processed sample if the third reagent added to the to-be-processed sample in the target area has the first target reagent information. Processing sample messages.
  • the second obtaining module 32 includes:
  • the identification sub-module is configured to identify the second target reagent information that matches the target sample information of the sample to be processed according to the preset second correspondence between the sample information and the second reagent information;
  • the processing module 33 includes:
  • the second query sub-module is used to query whether there is a second target reagent with the second target reagent information among the multiple second reagents respectively set in the multiple candidate regions;
  • the first control sub-module is configured to, if the second query sub-module finds the second target reagent with the second target reagent information among the multiple second reagents respectively arranged in the multiple candidate regions, and If the remaining amount of the second target reagent satisfies a preset condition, the suction device is controlled to suck the second target reagent from the target candidate area where the second target reagent is set;
  • the adding sub-module is configured to add the sucked second target reagent to the sample to be processed in the target area, and process the sample to be processed.
  • the device further includes:
  • the determining module is configured to determine that the remaining amount of the second target reagent meets a preset condition if the remaining amount of the second target reagent is greater than a first preset threshold.
  • the processing module 33 includes:
  • the second control sub-module is used to control the processing temperature and processing time in the target area
  • the recording sub-module is used to record the status information of the sample to be processed within the processing time
  • the second generation sub-module is used to generate a processing report according to the status information.
  • the target reagent information of the target reagent matching the sample to be processed can be obtained according to the target sample information of the sample to be processed in the target area; and the target reagent information is processed according to the target reagent information. sample.
  • the automatic incubation of the sample is realized, and the reagent information of the target reagent used for incubating the sample is suitable for the incubation of the sample to be processed, thereby improving the accuracy of the sample incubation and avoiding the artificial incubation of the sample.
  • the method of the embodiment of the present invention improves the flexibility, accuracy, and intelligence of incubating samples.
  • the description is relatively simple, and for related parts, please refer to the part of the description of the method embodiment.
  • the device embodiments described above are merely illustrative, where the units described as separate components may or may not be physically separated, and the components displayed as units may or may not be physical units, that is, they may be located in One place, or it can be distributed to multiple network units. Some or all of the modules can be selected according to actual needs to achieve the objectives of the solutions of the embodiments. Those of ordinary skill in the art can understand and implement it without creative work.
  • the various component embodiments of the present invention may be implemented by hardware, or by software modules running on one or more processors, or by a combination of them.
  • a microprocessor or a digital signal processor (DSP) may be used in practice to implement some or all of the functions of some or all of the components in the computing processing device according to the embodiments of the present invention.
  • DSP digital signal processor
  • the present invention can also be implemented as a device or device program (for example, a computer program and a computer program product) for executing part or all of the methods described herein.
  • Such a program for realizing the present invention may be stored on a computer-readable medium, or may have the form of one or more signals.
  • Such a signal can be downloaded from an Internet website, or provided on a carrier signal, or provided in any other form.
  • FIG. 4 shows a computing processing device that can implement the method according to the present invention.
  • the computing processing device traditionally includes a processor 1010 and a computer program product in the form of a memory 1020 or a computer readable medium.
  • the memory 1020 may be an electronic memory such as flash memory, EEPROM (Electrically Erasable Programmable Read Only Memory), EPROM, hard disk, or ROM.
  • the memory 1020 has a storage space 1030 for executing program codes 1031 of any method steps in the above methods.
  • the storage space 1030 for program codes may include various program codes 1031 respectively used to implement various steps in the above method. These program codes can be read from or written into one or more computer program products.
  • Such computer program products include program code carriers such as hard disks, compact disks (CDs), memory cards, or floppy disks.
  • Such a computer program product is usually a portable or fixed storage unit as described with reference to FIG. 5.
  • the storage unit may have storage segments, storage spaces, etc. arranged similarly to the memory 1020 in the computing processing device of FIG. 4.
  • the program code can be compressed in an appropriate form, for example.
  • the storage unit includes computer-readable code 1031', that is, code that can be read by a processor such as 1010, which, when run by a computing processing device, causes the computing processing device to execute the method described above. The various steps.
  • any reference signs placed between parentheses should not be constructed as a limitation to the claims.
  • the word “comprising” does not exclude the presence of elements or steps not listed in the claims.
  • the word “a” or “an” preceding an element does not exclude the presence of multiple such elements.
  • the invention can be implemented by means of hardware comprising several different elements and by means of a suitably programmed computer. In the unit claims listing several devices, several of these devices may be embodied in the same hardware item.
  • the use of the words first, second, and third, etc. do not indicate any order. These words can be interpreted as names.
  • the embodiments of the embodiments of the present invention may be provided as methods, devices, or computer program products. Therefore, the embodiments of the present invention may adopt the form of a complete hardware embodiment, a complete software embodiment, or an embodiment combining software and hardware. Moreover, the embodiments of the present invention may adopt the form of computer program products implemented on one or more computer-usable storage media (including but not limited to disk storage, CD-ROM, optical storage, etc.) containing computer-usable program codes.
  • computer-usable storage media including but not limited to disk storage, CD-ROM, optical storage, etc.
  • These computer program instructions can also be stored in a computer-readable memory that can guide a computer or other programmable data processing terminal equipment to work in a specific manner, so that the instructions stored in the computer-readable memory produce an article of manufacture including the instruction device.
  • the instruction device implements the functions specified in one process or multiple processes in the flowchart and/or one block or multiple blocks in the block diagram.
  • These computer program instructions can also be loaded on a computer or other programmable data processing terminal equipment, so that a series of operation steps are executed on the computer or other programmable terminal equipment to produce computer-implemented processing, so that the computer or other programmable terminal equipment
  • the instructions executed above provide steps for implementing functions specified in a flow or multiple flows in the flowchart and/or a block or multiple blocks in the block diagram.

Landscapes

  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Quality & Reliability (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

一种样本处理方法和装置,应用于诊断设备或与诊断设备连接的终端,方法包括:获取设置于目标区域内的待处理样本的目标样本信息(101);根据目标样本信息,获取与待处理样本匹配的目标试剂的目标试剂信息(102);根据目标试剂信息,处理待处理样本(103)。样本处理方法和装置能够提升了对样本温育的灵活性、准确率以及智能度。

Description

样本处理方法和装置
本申请要求在2019年12月31日提交中国专利局、申请号为201911423101.9、发明名称为“样本处理方法和装置”的中国专利申请的优先权,其全部内容通过引用结合在本申请中。
技术领域
本发明涉及样本处理技术领域,特别是涉及一种样本处理方法和装置。
背景技术
目前,不论是医药领域,还是化学实验领域,都会涉及对样本的温育。
在传统技术中,在对样本温育时需要人工配制并添加温育液,这种人工操作方式不够灵活、准确和智能。
发明内容
本发明提供了一种样本处理方法和装置,以解决相关技术中人工温育样本所存在的操作灵活性差、准确率低以及智能性差的问题。
为了解决上述问题,根据本发明的一个方面,本发明公开了一种样本处理方法,应用于诊断设备或与诊断设备连接的终端,该方法包括:
获取设置于目标区域内的待处理样本的目标样本信息;
根据所述目标样本信息,获取与所述待处理样本匹配的目标试剂的目标试剂信息;
根据所述目标试剂信息,处理所述待处理样本。
根据本发明的另一方面,本发明还公开了一种样本处理装置,应用于诊断设备或与诊断设备连接的终端,该装置包括:
第一获取模块,用于获取设置于目标区域内的待处理样本的目标样本信息;
第二获取模块,用于根据所述目标样本信息,获取与所述待处理样本匹配的目标试剂的目标试剂信息;
处理模块,用于根据所述目标试剂信息,处理所述待处理样本。
与现有技术相比,本发明包括以下优点:
在本发明实施例中,可以根据目标区域内待处理样本的目标样本信息,来获取与所述待处理样本匹配的目标试剂的目标试剂信息;并根据所述目标试剂信息,处理所述待处理样本。实现了对样本的自动温育,且用于温育样本的目标试剂的试剂信息是适用于对待处理样本的温育的,从而提升了对样本温育的准确率,避免了人工温育样本所存在的操作灵活性差、准确率低以及智能性差的问题,本发明实施例的方法提升了对样本温育的灵活性、准确率以及智能度。
上述说明仅是本发明技术方案的概述,为了能够更清楚了解本发明的技术手段,而可依照说明书的内容予以实施,并且为了让本发明的上述和其它目的、特征和优点能够更明显易懂,以下特举本发明的具体实施方式。
附图说明
为了更清楚地说明本发明实施例或现有技术中的技术方案,下面将对实施例或现有技术描述中所需要使用的附图作一简单地介绍,显而易见地,下面描述中的附图是本发明的一些实施例,对于本领域普通技术人员来讲,在不付出创造性劳动的前提下,还可以根据这些附图获得其他的附图。
图1是本发明的一种样本处理方法实施例的步骤流程图;
图2是本发明的另一种样本处理方法实施例的步骤流程图;
图3是本发明的一种样本处理装置实施例的结构框图;
图4示意性地示出了用于执行根据本发明的方法的计算处理设备的框图;以及
图5示意性地示出了用于保持或者携带实现根据本发明的方法的程序代码的存储单元。
具体实施例
为使本发明实施例的目的、技术方案和优点更加清楚,下面将结合本发明实施例中的附图,对本发明实施例中的技术方案进行清楚、完整地描述,显然,所描述的实施例是本发明一部分实施例,而不是全部的实施例。基于本发明中的实施例,本领域普通技术人员在没有作出创造性劳动前提下所获得的所有其他实施例,都属于本发明保护的范围。
本发明各个实施例可以应用到诊断设备或与诊断设备连接的终端。
其中,诊断设备可以为医疗诊断或检验时使用的设备,该诊断设备包括但不限于:生化分析仪、化学发光免疫分析仪、荧光免疫分析仪、免疫比浊分析仪、生化免疫一体机和基因测序仪。本发明采用全自动光激化学发光检测仪对本实施例进行详细说明。
参照图1,示出了本发明的一种样本处理方法实施例的步骤流程图,该方法可以应用于全自动光激化学发光检测仪,该方法具体可以包括如下步骤:
步骤101,获取设置于目标区域内的待处理样本的目标样本信息;
其中,目标区域可以为温育区,该温育区用于温育该待处理样本,也就是说,当有需要温育样本时,本发明实施例的方法可以将待温育样本(即待处理样本)放入温育区。
另外,一个温育区可以温育一个或多个待温育样本,因此,本步骤中的待处理样本的数量可以是一个或多个。
为了便于描述,后文各个实施例以待温育样本来描述该待处理样本,以温育区域来描述该目标区域。
另外,可以获取该温育区中的待温育样本的目标样本信息。
该目标样本信息可以包括样本的属性,例如样本名称、样本成分等。
可以理解的是,当温育区设置有多组待温育样本时,各组待温育样本是相互独立设置的,互不干扰。此外,在温育样本时,每个待温育样本内可以添加用于温育该样本的目标试剂。且,不同待温育样本对应的目标试剂可以相同或不同。其中,目标试剂可以包括至少一种试剂。
可选地,本发明实施例的方法可以应用到体外诊断设备的通用液管理流程中。
步骤102,根据所述目标样本信息,获取与所述待处理样本匹配的目标试剂的目标试剂信息;
步骤103,根据所述目标试剂信息,处理所述待处理样本。
在本发明实施例中,可以根据目标区域内待处理样本的目标样本信息,来获取与所述待处理样本匹配的目标试剂的目标试剂信息;并根据所述目标试剂信息,处理所述待处理样本。实现了对样本的自动温育,且用于温育样本的目标试剂的试剂信息是适用于对待处理样本的温育的,从而提升了对样本温育的准确率,避免了人工温育样本所存在的操作灵活性差、准确率低以及智能性差的问题,本发明实施例的方法提升了对样本温育的灵活性、准确率以及智能度。
可选地,在执行步骤103时,可以通过控制所述目标区域内的处理温度和处理时长;在所述处理时长内记录所述待处理样本的状态信息;根据所述状态信息生成处理报告。
其中,本发明实施例的方法可以对温育区内的温度进行控制,以及控制对该温育区内的待温育样本的温育时长(即处理时长);并可以在该温育时长内,实时记录待温育样本的状态信息;根据记录的待温育样本的状态信息,来形成该待温育样本的工作报告(即处理报告)。其中,该处理报告可以是一个文档。
在本发明实施例中,在对目标区域内的待处理样本进行温育的过程中,可以控制温育的温度以及温育的时长,并在温育过程中,实时记录目标区域内的待处理样本的状态信息,从而基于状态信息,来形成处理报告,该处理报告可以理解为对该待处理样本的处理结果,使得温育结果清晰可见,方便各种信息的追溯。
参照图2,示出了本发明的另一种样本处理方法实施例的步骤流程图,应用于诊断设备或与诊断设备连接的终端,该方法具体可以包括如下步骤:
可选地,步骤201,检测目标区域内是否存在待处理样本;
其中,可以检测目标区域(例如温育区)内是否存在待处理样本(例如待温育样本)。
可选地,若否,则步骤213,输出添加待处理样本的提示信息。即,如果该温育区内不存在待温育样本,则输出提示信息,来提示用户在温育区内添加待温育样本。
若是,则步骤202,获取所述待处理样本的目标样本信息;
此外,如果该温育区内存在待温育样本,对于该待温育样本的组数不做限制。本步骤则可以获取该温育区内每个待温育样本的目标样本信息(例如包括样本名称、样本成分等样本属性信息);
可选地,步骤206,获取所述待处理样本中已添加的第三试剂的试剂信息;
通过获取该待温育区中在该待温育样本中已经添加的第三试剂的试剂信息,可以确定待温育样本中已添加的第三试剂。
其中,获取的每个待温育样本中已经添加的第三试剂的试剂信息,例如可以包括试剂名称、试剂成分、试剂剂量等试剂属性信息。其中,各个待温育样本中所添加的第三试剂可以相同或不同。
步骤203,根据预设的样本信息与第一试剂信息的第一对应关系,查询与所述目标样本信息匹配的第一目标试剂的第一目标试剂信息;
其中,根据各个待温育样本的温育要求,可以对各个样本配置用于培育该样本的试剂的试剂信息(即试剂属性信息),因此,可以预先生成预设的样本信息(样本的属性信息,例如样本名称等)与第一试剂信息(试剂的属性信息,例如试剂的名称等)的第一对应关系,那么本步骤中,可以通过查询该第一对应关系,确定与该目标样本信息匹配的第一目标试剂的第一目标试剂信息。
另外,依据上述第一对应关系中所涉及的属性信息的差异,该第一对应关系可以是样本名称与试剂名称之间的对应关系,样本成分与试剂成分之间的对应关系,样本剂量与试剂剂量之间的对应关系这三类对应关系中的至少一类对应关系。
若所述目标区域内的所述待处理样本中已添加的第三试剂具有所述 第一目标试剂信息,则步骤204,生成确认所述第三试剂适用于处理所述待处理样本的消息。
其中,如果从所述第一对应关系中查询到的第一目标试剂信息正是该待温育样本中已经添加的第三试剂的试剂信息(例如第一目标试剂信息中的试剂名称、试剂量等必要的温育参数,与第三试剂的试剂名称、试剂量相同),则说明温育区的待温育样本中已添加的第三试剂是与该待温育样本相匹配的,即该第三试剂可以用于对该待温育样本进行准确的温育,所以可以生成一条消息,该消息表示第三试剂适用于处理所述待处理样本。
在本发明实施例中,可以利用预设的样本信息与第一试剂信息的第一对应关系,来确定目标区域中的待处理样本中已添加的第三试剂是否与该待处理样本相匹配,即该第三试剂是否能够用于对该待处理样本进行准确的温育,从而避免试剂添加错误所导致的样本温育失败的情况,提升了样本温育的准确率。
可选地,在一个实施例中,在步骤204之后,可以根据接收到的温育信息来采用所述第三试剂,对所述待处理样本进行处理。
具体而言,该温育信息例如可以包括但不限于目标区域内的目标处理温度和目标处理时长,从而可以通过控制所述目标区域内的温育温度为目标处理温度,以及控制温育时长为所述目标处理时长,采用所述第三试剂对该待处理样本进行温育处理,并在所述温育时长内记录所述待处理样本的状态信息;根据所述状态信息生成处理报告。
可选地,若所述目标区域内的所述待处理样本中已添加的第三试剂不具有所述第一目标试剂信息,则步骤214,输出表示待处理样本中已添加的第三试剂不适用于处理所述待处理样本的消息,并控制转移装置来将目标区域内的待处理样本移出该目标区域。
其中,该转移装置为样本处理装置的一个装置,该转移装置用于移动待处理样本、试剂、通用溶液等。该转移装置的具体结构不做限制,可以是任意已知或未来开发的用于移动样本、试剂以及溶液的装置。
其中,该诊断设备可以包括该转移装置。
在本步骤中,如果检测到待温育样本中已添加的第三试剂与待温育样本不匹配,则提示已添加第三试剂与待温育样本不匹配,并且将与第三试剂不匹配的待温育样本移出温育区。
可选地,在步骤204之后,在另一个实施例中,如图2所示,可以将步骤204生成的确认所述第三试剂适用于处理所述待处理样本的消息传递至执行步骤205的软件模块。
因此,在一个实施例中,该方法还可以包括步骤205,若接收到用于确认所述第三试剂适用于处理所述待处理样本的消息(则说明所述目标区域内的所述待处理样本中已添加的第三试剂具有所述第一目标试剂信息),根据预设的样本信息与第二试剂信息之间的第二对应关系,识别与所述待处理样本的目标样本信息相匹配的第二目标试剂信息;
其中,第二对应关系中的具有第二试剂信息的试剂可以称作通用溶液,也是一种试剂液体,由于该试剂液体可以通用于多个试剂温育项目,因此,可以将该试剂液体称为通用溶液;此外,通用溶液在对样本的检测过程中是作为一种试剂成分而参与到检测过程的。
本步骤中,如果确定温育区中各组待温育样本中所分别添加的第三试剂与对应的待温育样本是相互匹配的,则说明各组待温育样本中的第三试剂是添加准确的,即所添加的第三试剂确实可以用于温育被添加至的待温育样本,那么为了进一步确保待温育样本的温育,还需要依据上述第二对应关系来识别与温育区中的各个待温育样本的目标样本信息分别匹配的各个目标通用溶液(即各个第二目标试剂信息)。即,可以根据待温育样本来查找相应的目标通用溶液。
在本发明实施例中,可以根据各个待温育样本的温育要求,对各个样本配置用于培育该样本的第二试剂的第二试剂信息,因此,可以预先生成样本信息(样本的属性信息,例如样本名称、成分、剂量等)与第二试剂信息(通用溶液的属性信息,例如通用溶液的名称、成分、剂量等)的第二对应关系,那么本步骤中,可以通过查询该第二对应关系,可以识别与该目标样本信息(即待温育样本的属性信息)匹配的第二目标试剂信息(即目标通用溶液的属性信息)。
另外,依据上述第二对应关系中所涉及的属性信息的差异,该第二对应关系可以是样本名称与试剂名称之间的对应关系,样本成分与试剂成分之间的对应关系,样本剂量与试剂剂量之间的对应关系这三类对应关系中的至少一类对应关系。
步骤207,在分别设置于多个候选区域内的多种第二试剂中,查询是否存在具有所述第二目标试剂信息的第二目标试剂。
其中,第二试剂可以设置在候选区域,不同种的第二试剂可以设置于不同的候选区域中,因此,本步骤中可以在设置于多个候选区域内的多种第二试剂中,查询是否存在上述待温育样本所需要的第二目标试剂。
其中,可以对设置于多个候选区域内的多种第二试剂分别获取其属性信息(例如包括第二试剂的名称、成分、剩余量等属性信息),那么利用该属性信息,就可以确定多个候选区域中是否存在具有第二目标试剂信息(例如第二试剂的名称、成分)的第二目标试剂。
若分别设置于多个候选区域内的多种第二试剂中,存在具有所述第二目标试剂信息的第二目标试剂,且所述第二目标试剂的剩余量满足预设条件,则步骤208,控制吸取装置从设置有所述第二目标试剂的目标候选区域中吸取所述第二目标试剂;
其中,如果多个候选区域中存在例如设置于目标候选区域内的第二目标试剂,并且,该第二目标试剂的剩余量(即剩余容量)满足预设条件,则控制吸取装置来从该目标候选区域中吸取该第二目标试剂。
可选地,在确定第二目标试剂位于哪个候选区域时,在将多种第二试剂分别设置与各个候选区域之后,可以预先生成候选区域的编号与第二试剂的标识之间的对应关系,那么通过查询该对应关系,则可以获取到与第二目标试剂的标识所匹配的候选区域的目标编号,从而将设置在具有目标编号的目标候选区域内的第二试剂识别为第二目标试剂。
其中,该诊断设备可以包括该吸取装置。
其中,吸取装置为用于吸取试剂等液体,并将吸取的液体添加到待处理样本的一种装置,本发明对其具体结构不做限制,可以参照已有技术。
例如,可以控制吸取装置从目标候选区域吸取该第二目标试剂,并将吸取的第二目标试剂添加到温育区内的待温育样本中,使得待温育样本中不仅添加有第三试剂,还添加有该第二目标试剂。
步骤209,将吸取的所述第二目标试剂添加至所述目标区域内的所述待处理样本中,处理所述待处理样本。
在本发明实施例中,可以利用预设的样本信息与第二试剂信息的第二对应关系,来确定多个候选区域内的多种第二试剂中是否存在与该待处理样本相匹配的第二目标试剂,那么在存在的情况下,则可以用设置与目标候选区域内的第二目标试剂来对该待处理样本进行准确的温育,从而避免通用溶液添加错误所导致的样本温育失败的情况,提升了样本温育的准确率。且在候选区域中存在第二目标试剂的情况下,还可以进一步确定第二目标试剂的剩余量满足预设条件的情况下,则控制吸取装置来从设置有该第二目标试剂的目标候选区域中吸取第二目标试剂来添加到目标区域内的待处理样本中,使得在对待处理样本温育时,所添加的目标试剂(第二目标试剂的情况,或者,第二目标试剂和第三试剂的情况)都与该待处理样本相匹配,确保样本温育的准确;并且,能够在添加第二目标试剂之前,确定该第二目标试剂的剩余量是否满足预设条件,从而避免在第二目标试剂的剩余量不足时,对待处理样本温育失败的情况,上述过程实现了对样本的自动温育,避免了人工温育样本所存在的操作灵活性差、准确率低以及智能性差的问题,本发明实施例的方法提升了对样本温育的灵活性、准确率以及智能度。
可选地,若分别设置于多个候选区域内的多种第二试剂中,存在具有所述第二目标试剂信息的第二目标试剂,且所述第二目标试剂的剩余量不满足预设条件,则步骤215,输出表示第二目标试剂的剩余量不足的提示信息,并停止对所述目标区域内的待处理样本进行处理。
即,输出表示位于目标候选区域内的第二目标试剂的剩余量不足的提示信息,方便用户对目标候选区域内的第二目标试剂继续注入溶液;同时,本发明实施例的方法还会停止对温育区内的待温育样本进行温育。
可选地,在判断所述第二目标试剂的剩余量是否满足预设条件时, 若所述第二目标试剂的剩余量大于第一预设阈值,则确定所述第二目标试剂的剩余量满足预设条件;否则,不满足预设条件。
其中,可以通过大量实验来生成用于温育样本的第二试剂的最低剂量要求,即第一预设阈值,那么如果位于目标候选区域内的第二目标试剂的剩余量大于该第一预设阈值,则说明该第二目标试剂的剩余量可以满足对该待温育样本的温育要求,因此,确定所述第二目标试剂的剩余量满足预设条件。
也就是说,第二目标试剂加液量是提前系统设置好的,获取第二目标试剂时判断下剩余的量是否大于需要的量,若是就可以取液。
在本发明实施例中,可以在第二目标试剂的剩余量大于该第一预设阈值时,确定该第二目标试剂液的剩余量可以满足对待处理样本的处理要求,避免因第二目标试剂的剂量不够所导致的对待处理样本的温育失败的情况。
可选地,在执行步骤209的处理待处理样本的步骤时,可以通过控制所述目标区域内的处理温度和处理时长,并在所述处理时长内记录所述待处理样本的状态信息,最后,根据所述状态信息生成处理报告。
在图2实施例中,在温育样本时,可以采用第三试剂温育样本,或者采用第二目标试剂来温育样本,或者采用第三试剂以及第二目标试剂来温育样本。
在本发明实施例中,在温育待处理样本时,可以判断该待处理样本中已添加的第三试剂与待处理样本是否匹配,可以在匹配的情况下,识别与待处理样本匹配的第二目标试剂,并确定多个候选区域中是否存在该第二目标试剂,在存在该第二目标试剂,且该第二目标试剂的剩余量满足预设条件的情况下,则可以控制吸取装置来从设置有该第二目标试剂的目标候选区域中吸取第二目标试剂来添加到目标区域内的待处理样本中,使得在对待处理样本温育时,所添加的第三试剂和第二目标试剂都与该待处理样本相匹配,并且,能够在添加第二目标试剂之前,确定该第二目标试剂的剩余量是否满足预设条件,从而避免在第二目标试剂的剩余量不足时,对待处理样本温育失败的情况,上述过程实现了对样 本的自动温育,避免了人工温育样本所存在的操作灵活性差、准确率低以及智能性差的问题,本发明实施例的方法提升了对样本温育的灵活性、准确率以及智能度。
需要说明的是,对于方法实施例,为了简单描述,故将其都表述为一系列的动作组合,但是本领域技术人员应该知悉,本发明实施例并不受所描述的动作顺序的限制,因为依据本发明实施例,某些步骤可以采用其他顺序或者同时进行。其次,本领域技术人员也应该知悉,说明书中所描述的实施例均属于优选实施例,所涉及的动作并不一定是本发明实施例所必须的。
与上述本发明实施例所提供的方法相对应,参照图3,示出了本发明一种样本处理装置实施例的结构框图,应用于诊断设备或与诊断设备连接的终端,该装置具体可以包括如下模块:
第一获取模块31,用于获取设置于目标区域内的待处理样本的目标样本信息;
第二获取模块32,用于根据所述目标样本信息,获取与所述待处理样本匹配的目标试剂的目标试剂信息;
处理模块33,用于根据所述目标试剂信息,处理所述待处理样本。
可选地,所述第二获取模块32包括:
第一查询子模块,用于根据预设的样本信息与第一试剂信息的第一对应关系,查询与所述目标样本信息匹配的第一目标试剂的第一目标试剂信息;
所述处理模块33包括:
第一生成子模块,用于若所述目标区域内的所述待处理样本中已添加的第三试剂具有所述第一目标试剂信息,则生成确认所述第三试剂适用于处理所述待处理样本的消息。
可选地,所述第二获取模块32包括:
识别子模块,用于根据预设的样本信息与第二试剂信息之间的第二对应关系,识别与所述待处理样本的目标样本信息相匹配的第二目标试剂信息;
所述处理模块33包括:
第二查询子模块,用于在分别设置于多个候选区域内的多种第二试剂中,查询是否存在具有所述第二目标试剂信息的第二目标试剂;
第一控制子模块,用于若所述第二查询子模块在分别设置于多个候选区域内的多种第二试剂中,查询到具有所述第二目标试剂信息的第二目标试剂、且所述第二目标试剂的剩余量满足预设条件,则控制吸取装置从设置有所述第二目标试剂的目标候选区域中吸取所述第二目标试剂;
添加子模块,用于将吸取的所述第二目标试剂添加至所述目标区域内的所述待处理样本中,处理所述待处理样本。
可选地,所述装置还包括:
确定模块,用于若所述第二目标试剂的剩余量大于第一预设阈值,则确定所述第二目标试剂的剩余量满足预设条件。
可选地,所述处理模块33包括:
第二控制子模块,用于控制所述目标区域内的处理温度和处理时长;
记录子模块,用于在所述处理时长内记录所述待处理样本的状态信息;
第二生成子模块,用于根据所述状态信息生成处理报告。
在本发明实施例中,可以根据目标区域内待处理样本的目标样本信息,来获取与所述待处理样本匹配的目标试剂的目标试剂信息;并根据所述目标试剂信息,处理所述待处理样本。实现了对样本的自动温育,且用于温育样本的目标试剂的试剂信息是适用于对待处理样本的温育的,从而提升了对样本温育的准确率,避免了人工温育样本所存在的操作灵活性差、准确率低以及智能性差的问题,本发明实施例的方法提升了对样本温育的灵活性、准确率以及智能度。
对于装置实施例而言,由于其与方法实施例基本相似,所以描述的比较简单,相关之处参见方法实施例的部分说明即可。
本说明书中的各个实施例均采用递进的方式描述,每个实施例重点说明的都是与其他实施例的不同之处,各个实施例之间相同相似的部分 互相参见即可。
以上所描述的装置实施例仅仅是示意性的,其中所述作为分离部件说明的单元可以是或者也可以不是物理上分开的,作为单元显示的部件可以是或者也可以不是物理单元,即可以位于一个地方,或者也可以分布到多个网络单元上。可以根据实际的需要选择其中的部分或者全部模块来实现本实施例方案的目的。本领域普通技术人员在不付出创造性的劳动的情况下,即可以理解并实施。
本发明的各个部件实施例可以以硬件实现,或者以在一个或者多个处理器上运行的软件模块实现,或者以它们的组合实现。本领域的技术人员应当理解,可以在实践中使用微处理器或者数字信号处理器(DSP)来实现根据本发明实施例的计算处理设备中的一些或者全部部件的一些或者全部功能。本发明还可以实现为用于执行这里所描述的方法的一部分或者全部的设备或者装置程序(例如,计算机程序和计算机程序产品)。这样的实现本发明的程序可以存储在计算机可读介质上,或者可以具有一个或者多个信号的形式。这样的信号可以从因特网网站上下载得到,或者在载体信号上提供,或者以任何其他形式提供。
例如,图4示出了可以实现根据本发明的方法的计算处理设备。该计算处理设备传统上包括处理器1010和以存储器1020形式的计算机程序产品或者计算机可读介质。存储器1020可以是诸如闪存、EEPROM(电可擦除可编程只读存储器)、EPROM、硬盘或者ROM之类的电子存储器。存储器1020具有用于执行上述方法中的任何方法步骤的程序代码1031的存储空间1030。例如,用于程序代码的存储空间1030可以包括分别用于实现上面的方法中的各种步骤的各个程序代码1031。这些程序代码可以从一个或者多个计算机程序产品中读出或者写入到这一个或者多个计算机程序产品中。这些计算机程序产品包括诸如硬盘,紧致盘(CD)、存储卡或者软盘之类的程序代码载体。这样的计算机程序产品通常为如参考图5所述的便携式或者固定存储单元。该存储单元可以具有与图4的计算处理设备中的存储器1020类似布置的存储段、存储空间等。程序代码可以例如以适当形式进行压缩。通常,存储单元包括计算机可读代码1031’,即可以由例如诸如1010之类的处理器读取的代码,这些代码当由计算处理设备运行时,导致该计算处理设备执行上面所描 述的方法中的各个步骤。
本文中所称的“一个实施例”、“实施例”或者“一个或者多个实施例”意味着,结合实施例描述的特定特征、结构或者特性包括在本发明的至少一个实施例中。此外,请注意,这里“在一个实施例中”的词语例子不一定全指同一个实施例。
在此处所提供的说明书中,说明了大量具体细节。然而,能够理解,本发明的实施例可以在没有这些具体细节的情况下被实践。在一些实例中,并未详细示出公知的方法、结构和技术,以便不模糊对本说明书的理解。
在权利要求中,不应将位于括号之间的任何参考符号构造成对权利要求的限制。单词“包含”不排除存在未列在权利要求中的元件或步骤。位于元件之前的单词“一”或“一个”不排除存在多个这样的元件。本发明可以借助于包括有若干不同元件的硬件以及借助于适当编程的计算机来实现。在列举了若干装置的单元权利要求中,这些装置中的若干个可以是通过同一个硬件项来具体体现。单词第一、第二、以及第三等的使用不表示任何顺序。可将这些单词解释为名称。
最后应说明的是:以上实施例仅用以说明本发明的技术方案,而非对其限制;尽管参照前述实施例对本发明进行了详细的说明,本领域的普通技术人员应当理解:其依然可以对前述各实施例所记载的技术方案进行修改,或者对其中部分技术特征进行等同替换;而这些修改或者替换,并不使相应技术方案的本质脱离本发明各实施例技术方案的精神和范围。
本领域内的技术人员应明白,本发明实施例的实施例可提供为方法、装置、或计算机程序产品。因此,本发明实施例可采用完全硬件实施例、完全软件实施例、或结合软件和硬件方面的实施例的形式。而且,本发明实施例可采用在一个或多个其中包含有计算机可用程序代码的计算机可用存储介质(包括但不限于磁盘存储器、CD-ROM、光学存储器等)上实施的计算机程序产品的形式。
本发明实施例是参照根据本发明实施例的方法、终端设备(系统)、和计算机程序产品的流程图和/或方框图来描述的。应理解可由计算机程序指令实现流程图和/或方框图中的每一流程和/或方框、以及流程图 和/或方框图中的流程和/或方框的结合。可提供这些计算机程序指令到通用计算机、专用计算机、嵌入式处理机或其他可编程数据处理终端设备的处理器以产生一个机器,使得通过计算机或其他可编程数据处理终端设备的处理器执行的指令产生用于实现在流程图一个流程或多个流程和/或方框图一个方框或多个方框中指定的功能的装置。
这些计算机程序指令也可存储在能引导计算机或其他可编程数据处理终端设备以特定方式工作的计算机可读存储器中,使得存储在该计算机可读存储器中的指令产生包括指令装置的制造品,该指令装置实现在流程图一个流程或多个流程和/或方框图一个方框或多个方框中指定的功能。
这些计算机程序指令也可装载到计算机或其他可编程数据处理终端设备上,使得在计算机或其他可编程终端设备上执行一系列操作步骤以产生计算机实现的处理,从而在计算机或其他可编程终端设备上执行的指令提供用于实现在流程图一个流程或多个流程和/或方框图一个方框或多个方框中指定的功能的步骤。
尽管已描述了本发明实施例的优选实施例,但本领域内的技术人员一旦得知了基本创造性概念,则可对这些实施例做出另外的变更和修改。所以,所附权利要求意欲解释为包括优选实施例以及落入本发明实施例范围的所有变更和修改。
最后,还需要说明的是,在本文中,诸如第一和第二等之类的关系术语仅仅用来将一个实体或者操作与另一个实体或操作区分开来,而不一定要求或者暗示这些实体或操作之间存在任何这种实际的关系或者顺序。而且,术语“包括”、“包含”或者其任何其他变体意在涵盖非排他性的包含,从而使得包括一系列要素的过程、方法、物品或者终端设备不仅包括那些要素,而且还包括没有明确列出的其他要素,或者是还包括为这种过程、方法、物品或者终端设备所固有的要素。在没有更多限制的情况下,由语句“包括一个……”限定的要素,并不排除在包括所述要素的过程、方法、物品或者终端设备中还存在另外的相同要素。
以上对本发明所提供的一种样本处理方法和一种样本处理装置,进 行了详细介绍,本文中应用了具体个例对本发明的原理及实施方式进行了阐述,以上实施例的说明只是用于帮助理解本发明的方法及其核心思想;同时,对于本领域的一般技术人员,依据本发明的思想,在具体实施方式及应用范围上均会有改变之处,综上所述,本说明书内容不应理解为对本发明的限制。

Claims (13)

  1. 一种样本处理方法,应用于诊断设备或与诊断设备连接的终端,其特征在于,包括:
    获取设置于目标区域内的待处理样本的目标样本信息;
    根据所述目标样本信息,获取与所述待处理样本匹配的目标试剂的目标试剂信息;
    根据所述目标试剂信息,处理所述待处理样本。
  2. 根据权利要求1所述的方法,其特征在于,
    所述根据所述目标样本信息,获取与所述待处理样本匹配的目标试剂的目标试剂信息,包括:
    根据预设的样本信息与第一试剂信息的第一对应关系,查询与所述目标样本信息匹配的第一目标试剂的第一目标试剂信息;
    所述根据所述目标试剂信息,处理所述待处理样本,包括:
    若所述目标区域内的所述待处理样本中已添加的第三试剂具有所述第一目标试剂信息,则生成确认所述第三试剂适用于处理所述待处理样本的消息。
  3. 根据权利要求1或2所述的方法,其特征在于,
    所述根据所述目标样本信息,获取与所述待处理样本匹配的目标试剂的目标试剂信息,包括:
    根据预设的样本信息与第二试剂信息之间的第二对应关系,识别与所述待处理样本的目标样本信息相匹配的第二目标试剂信息;
    所述根据所述目标试剂信息,处理所述待处理样本,包括:
    在分别设置于多个候选区域内的多种第二试剂中,查询是否存在具有所述第二目标试剂信息的第二目标试剂;
    若是、且所述第二目标试剂的剩余量满足预设条件,则控制吸取装置从设置有所述第二目标试剂的目标候选区域中吸取所述第二目标试剂;
    将吸取的所述第二目标试剂添加至所述目标区域内的所述待处理样本中,处理所述待处理样本。
  4. 根据权利要求3所述的方法,其特征在于,所述第二目标试剂的剩余量满足预设条件,包括:
    若所述第二目标试剂的剩余量大于第一预设阈值,则确定所述第二目标试剂的剩余量满足预设条件。
  5. 根据权利要求1所述的方法,其特征在于,所述根据所述目标试剂信息,处理所述待处理样本,包括:
    控制所述目标区域内的处理温度和处理时长;
    在所述处理时长内记录所述待处理样本的状态信息;
    根据所述状态信息生成处理报告。
  6. 一种样本处理装置,应用于诊断设备或与诊断设备连接的终端,其特征在于,包括:
    第一获取模块,用于获取设置于目标区域内的待处理样本的目标样本信息;
    第二获取模块,用于根据所述目标样本信息,获取与所述待处理样本匹配的目标试剂的目标试剂信息;
    处理模块,用于根据所述目标试剂信息,处理所述待处理样本。
  7. 根据权利要求6所述的装置,其特征在于,
    所述第二获取模块包括:
    第一查询子模块,用于根据预设的样本信息与第一试剂信息的第一对应关系,查询与所述目标样本信息匹配的第一目标试剂的第一目标试剂信息;
    所述处理模块包括:
    第一生成子模块,用于若所述目标区域内的所述待处理样本中已添加的第三试剂具有所述第一目标试剂信息,则生成确认所述第三试剂适用于处理所述待处理样本的消息。
  8. 根据权利要求6或7所述的装置,其特征在于,
    所述第二获取模块包括:
    识别子模块,用于根据预设的样本信息与第二试剂信息之间的第二对应关系,识别与所述待处理样本的目标样本信息相匹配的第二目标试剂信息;
    所述处理模块包括:
    第二查询子模块,用于在分别设置于多个候选区域内的多种第二试剂中,查询是否存在具有所述第二目标试剂信息的第二目标试剂;
    第一控制子模块,用于若所述第二查询子模块在分别设置于多个候选区域内的多种第二试剂中,查询到具有所述第二目标试剂信息的第二目标试剂、且所述第二目标试剂的剩余量满足预设条件,则控制吸取装置从设置有所述第二目标试剂的目标候选区域中吸取所述第二目标试剂;
    添加子模块,用于将吸取的所述第二目标试剂添加至所述目标区域内的所述待处理样本中,处理所述待处理样本。
  9. 根据权利要求8所述的装置,其特征在于,所述装置还包括:
    确定模块,用于若所述第二目标试剂的剩余量大于第一预设阈值,则确定所述第二目标试剂的剩余量满足预设条件。
  10. 根据权利要求6所述的装置,其特征在于,所述处理模块包括:
    第二控制子模块,用于控制所述目标区域内的处理温度和处理时长;
    记录子模块,用于在所述处理时长内记录所述待处理样本的状态信息;
    第二生成子模块,用于根据所述状态信息生成处理报告。
  11. 一种计算处理设备,其特征在于,包括:
    存储器,其中存储有计算机可读代码;
    一个或多个处理器,当所述计算机可读代码被所述一个或多个处理器执行时,所述计算处理设备执行如权利要求1-5中任一项所述的样本处理方法。
  12. 一种计算机程序,包括计算机可读代码,当所述计算机可读代码在计算处理设备上运行时,导致所述计算处理设备执行根据权利要求1-5中任一项所述的样本处理方法。
  13. 一种计算机可读介质,其中存储了如权利要求12所述的计算机程序。
PCT/CN2020/114209 2019-12-31 2020-09-09 样本处理方法和装置 WO2021135368A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201911423101.9 2019-12-31
CN201911423101.9A CN113125779A (zh) 2019-12-31 2019-12-31 样本处理方法和装置

Publications (1)

Publication Number Publication Date
WO2021135368A1 true WO2021135368A1 (zh) 2021-07-08

Family

ID=76687540

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CN2020/114209 WO2021135368A1 (zh) 2019-12-31 2020-09-09 样本处理方法和装置

Country Status (2)

Country Link
CN (1) CN113125779A (zh)
WO (1) WO2021135368A1 (zh)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN117491654B (zh) * 2023-12-15 2024-03-19 广州誉康医药有限公司 一种提升试剂卡的利用率和样本的添加效率的方法

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070172390A1 (en) * 2006-01-23 2007-07-26 Sysmex Corporation Analyzing apparatus, solid-liquid separation device and solid-liquid separation method
CN101126761A (zh) * 2006-08-18 2008-02-20 希森美康株式会社 凝血分析仪及凝血分析方法
CN102147406A (zh) * 2011-02-14 2011-08-10 四川迈克生物科技股份有限公司 全自动化学发光免疫分析仪
CN102565437A (zh) * 2010-10-12 2012-07-11 希森美康株式会社 样本分析装置
CN102998473A (zh) * 2012-12-19 2013-03-27 北京利德曼生化股份有限公司 全自动化学发光免疫分析仪
CN104111341A (zh) * 2013-04-16 2014-10-22 深圳迈瑞生物医疗电子股份有限公司 自动分析装置及其分析方法和分析系统
CN106645765A (zh) * 2017-01-06 2017-05-10 刘丹 自动分析装置及样本分析方法
CN106841645A (zh) * 2017-01-06 2017-06-13 刘丹 一种反应孵育装置、免疫分析仪及反应孵育方法

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070172390A1 (en) * 2006-01-23 2007-07-26 Sysmex Corporation Analyzing apparatus, solid-liquid separation device and solid-liquid separation method
CN101126761A (zh) * 2006-08-18 2008-02-20 希森美康株式会社 凝血分析仪及凝血分析方法
CN102565437A (zh) * 2010-10-12 2012-07-11 希森美康株式会社 样本分析装置
CN102147406A (zh) * 2011-02-14 2011-08-10 四川迈克生物科技股份有限公司 全自动化学发光免疫分析仪
CN102998473A (zh) * 2012-12-19 2013-03-27 北京利德曼生化股份有限公司 全自动化学发光免疫分析仪
CN104111341A (zh) * 2013-04-16 2014-10-22 深圳迈瑞生物医疗电子股份有限公司 自动分析装置及其分析方法和分析系统
CN106645765A (zh) * 2017-01-06 2017-05-10 刘丹 自动分析装置及样本分析方法
CN106841645A (zh) * 2017-01-06 2017-06-13 刘丹 一种反应孵育装置、免疫分析仪及反应孵育方法

Also Published As

Publication number Publication date
CN113125779A (zh) 2021-07-16

Similar Documents

Publication Publication Date Title
Gargis et al. Assuring the quality of next-generation sequencing in clinical microbiology and public health laboratories
Egerstedt et al. Profiling of the plasma proteome across different stages of human heart failure
Lun et al. A step-by-step workflow for low-level analysis of single-cell RNA-seq data with Bioconductor
Adams et al. Diagnosis of plant viruses using next-generation sequencing and metagenomic analysis
Powell et al. Application of matrix-assisted laser desorption ionization–time of flight mass spectrometry for identification of the fastidious pediatric pathogens Aggregatibacter, Eikenella, Haemophilus, and Kingella
Yang et al. Prognostic role of pre‐treatment serum albumin in patients with nasopharyngeal carcinoma: a meta‐analysis and systematic review
Melsted et al. Fusion detection and quantification by pseudoalignment
Trost et al. Concordance between RNA-sequencing data and DNA microarray data in transcriptome analysis of proliferative and quiescent fibroblasts
WO2021135368A1 (zh) 样本处理方法和装置
Hsu et al. Detection of the inferred interaction network in hepatocellular carcinoma from EHCO (E ncyclopedia of H epatocellular C arcinoma genes O nline)
Zhou et al. Both peripheral blood and urinary miR-195-5p, miR-192-3p, miR-328-5p and their target genes PPM1A, RAB1A and BRSK1 may be potential biomarkers for membranous nephropathy
Kumar et al. ScreenSifter: analysis and visualization of RNAi screening data
Villanueva-Cañas et al. Implementation of an open-source robotic platform for SARS-CoV-2 testing by real-time RT-PCR
Gordillo et al. Evaluation of the COBAS TaqMan 48 real-time PCR system for quantitation of hepatitis B virus DNA
Scott et al. Assessment of plasma cell myeloma minimal residual disease testing by flow cytometry in an international inter‐laboratory study: Is it ready for primetime use?
Eldosoky et al. Diagnostic significance of hsa-miR-21-5p, hsa-miR-192-5p, hsa-miR-155-5p, hsa-miR-199a-5p panel and ratios in hepatocellular carcinoma on top of liver cirrhosis in HCV-infected patients
Ahmed et al. JWES: a new pipeline for whole genome/exome sequence data processing, management, and gene‐variant discovery, annotation, prediction, and genotyping
Murad et al. SARS-CoV-2 infection detection by PCR and serologic testing in clinical practice
Wirth et al. Spatial transcriptomics using multiplexed deterministic barcoding in tissue
Steward et al. Clinical diagnostic gene expression thyroid testing
Azzalini et al. Reliability of miRNA analysis from fixed and paraffin-embedded tissues
Momoi et al. Detection of severe fever with thrombocytopenia syndrome virus and other viruses in cats via unbiased next-generation sequencing
Mitchell et al. Adoption of lean principles in a high-volume molecular diagnostic microbiology laboratory
Li et al. Kikuchi-Fujimoto disease is mediated by an aberrant type I interferon response
CN116521896A (zh) 一种基于图的负样本获取方法和系统

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 20910252

Country of ref document: EP

Kind code of ref document: A1

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 20910252

Country of ref document: EP

Kind code of ref document: A1