WO2021121235A1 - Sleep monitoring and regulation method and apparatus based on human body multimode signal - Google Patents

Sleep monitoring and regulation method and apparatus based on human body multimode signal Download PDF

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WO2021121235A1
WO2021121235A1 PCT/CN2020/136635 CN2020136635W WO2021121235A1 WO 2021121235 A1 WO2021121235 A1 WO 2021121235A1 CN 2020136635 W CN2020136635 W CN 2020136635W WO 2021121235 A1 WO2021121235 A1 WO 2021121235A1
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sleep
signal
monitoring
signals
pin
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PCT/CN2020/136635
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French (fr)
Chinese (zh)
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刘铁军
郜东瑞
谢佳欣
宋晓宇
黄振祥
赵威
李春燕
吕彬
任俊如
尧德中
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电子科技大学
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/24Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • A61B5/316Modalities, i.e. specific diagnostic methods
    • A61B5/369Electroencephalography [EEG]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/02Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
    • A61B5/0205Simultaneously evaluating both cardiovascular conditions and different types of body conditions, e.g. heart and respiratory condition
    • A61B5/02055Simultaneously evaluating both cardiovascular condition and temperature
    • AHUMAN NECESSITIES
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    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/08Detecting, measuring or recording devices for evaluating the respiratory organs
    • AHUMAN NECESSITIES
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    • A61B5/08Detecting, measuring or recording devices for evaluating the respiratory organs
    • A61B5/0826Detecting or evaluating apnoea events
    • AHUMAN NECESSITIES
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    • A61B5/103Detecting, measuring or recording devices for testing the shape, pattern, colour, size or movement of the body or parts thereof, for diagnostic purposes
    • A61B5/11Measuring movement of the entire body or parts thereof, e.g. head or hand tremor, mobility of a limb
    • A61B5/1118Determining activity level
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    • A61B5/24Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • A61B5/316Modalities, i.e. specific diagnostic methods
    • A61B5/318Heart-related electrical modalities, e.g. electrocardiography [ECG]
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    • A61B5/24Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • A61B5/316Modalities, i.e. specific diagnostic methods
    • A61B5/398Electrooculography [EOG], e.g. detecting nystagmus; Electroretinography [ERG]
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    • A61B5/4806Sleep evaluation
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    • A61B5/7264Classification of physiological signals or data, e.g. using neural networks, statistical classifiers, expert systems or fuzzy systems
    • A61B5/7267Classification of physiological signals or data, e.g. using neural networks, statistical classifiers, expert systems or fuzzy systems involving training the classification device
    • AHUMAN NECESSITIES
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    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M21/00Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis
    • A61M21/02Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis for inducing sleep or relaxation, e.g. by direct nerve stimulation, hypnosis, analgesia
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    • A61M2021/0022Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis by the use of a particular sense, or stimulus by the tactile sense, e.g. vibrations
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    • A61M2021/0044Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis by the use of a particular sense, or stimulus by the sight sense
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    • A61M21/00Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis
    • A61M2021/0005Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis by the use of a particular sense, or stimulus
    • A61M2021/0066Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis by the use of a particular sense, or stimulus with heating or cooling
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M21/00Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis
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    • A61M2021/0072Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis by the use of a particular sense, or stimulus with application of electrical currents

Definitions

  • the invention belongs to the technical field of sleep monitoring, and specifically relates to a sleep monitoring and regulation method and device based on human multi-mode signals.
  • the sleep state monitoring and evaluation system is widely regarded as a dedicated polysomnography (PSG), but the system is large in size and requires a dedicated computer for data analysis and collection. Moreover, it requires professional help to use it.
  • PSG polysomnography
  • the sleep action value and action frequency of the human body are activated by the acceleration sensor, and the sleep state is judged based on this.
  • this method also has two problems: 1. The results can only be used as reference data, with low credibility, and cannot be used as a basis for medical monitoring of sleep. For example, when the user is lying still in bed in a daze, the invention cannot determine whether the user is asleep or awake; 2. The patent cannot determine the level of sleep. For effective division, only statistical estimation can be made;
  • the patent CN 109009149 A document judges the human's physiological state based on the contraction of the abdominal cavity. It is characterized by the automatic driving system.
  • the problem is that the invention has a single function and can only monitor the breathing signal to monitor the sleep of high-risk groups. Classify and judge sleep quality; and the data in this invention needs to be sent to a special terminal for processing, which cannot reflect real-time performance;
  • the patent document CN109222961A judges sleep quality based on ECG and respiratory signals. It has a certain scientific basis, but there are some problems in practical applications. For example, the accuracy of the patent’s sleep quality evaluation is low.
  • Multimodal information Improve the rapid detection of mental fatigue” research pointed out that EEG signals are the “gold standard” for sleep quality evaluation, with an accuracy rate of over 95%, while the accuracy rate of other physiological signals such as ECG for evaluating sleep quality is less than 85%;
  • the patent document CN109350016A also evaluates the quality of sleep through the ECG and respiratory signals. Compared with CN109222961A, it only uses the wireless reflection method to obtain these signals. There is also the problem of low classification accuracy, and the focus of the invention is Sleep classification method, but this aspect is relatively simple, just after a simple pre-processing, FFT changes, the selection of data features is not obvious;
  • Document CN109480787A is an upgrade and improvement of patent CN109350016A. It uses radar waves to obtain ECG and respiration signals. Compared with patent CN109350016A, this method improves the accuracy of sleep quality evaluation to a certain extent, but it also has the following problems: As the core of sleep quality evaluation, the results of EEG cannot be recognized in the medical field; the second is that radar is electromagnetic radiation, which poses a certain safety risk to the human body; the third is the analysis and processing of data, which requires a special computer, which is inconvenient and costly. Higher.
  • one of the objectives of the present invention is to provide a sleep monitoring and regulation method based on human multi-mode signals, which can quickly monitor sleep and regulate the sleep environment according to the monitoring results.
  • the technical solution of the present invention is: a sleep monitoring and control method based on human multi-mode signals, including the following steps:
  • physiological signals include brain electrical signals, electrocardiographic signals, eye electrical signals, respiration signals, body temperature signals, and body movement signals;
  • Analyze the physiological signals and monitor the sleep state use the brain electrical signal, the eye electrical signal, and the body movement signal to evaluate the sleep state and sleep stage, use the electrocardiographic signal, the The breathing signal is used to monitor the physical state of the user, and the body temperature signal is used to monitor changes in body temperature;
  • step of evaluating the sleep state and sleep stage specifically includes:
  • the classification accuracy and generalization performance of the staging model are tested, and the model with the best test result is selected as the automatic staging model.
  • the step of regulating the sleep environment according to the monitoring structure specifically includes: outputting current control parameters according to the monitoring result, so as to realize the micro-current stimulation to different regions of the human brain and adjust the sleep state;
  • the temperature control parameters are output to adjust the sleep environment temperature.
  • EEG signals of different sleeping postures are collected through the dry electrode array.
  • the second objective of the present invention is to provide a sleep monitoring and control device based on human multi-mode signals, which can detect sleep status, classify sleep quality, and can specifically use micro current, light, temperature, somatosensory massage, etc. Ways to implement regulation to help users improve sleep quality.
  • a sleep monitoring and regulating device based on human multi-mode signals including a sleep regulating bed, and a sleep monitoring module and a sleep regulating module arranged on the sleep regulating bed;
  • the sleep monitoring module is used to obtain physiological signals and analyze them according to the physiological signals to monitor the sleep state; wherein, the physiological signals include brain electrical signals, electrocardiographic signals, eye electrical signals, respiration signals, body temperature signals And body movement signals;
  • the sleep control module is signal-connected with the sleep monitoring module, and is used for outputting control parameters for regulating the sleep environment according to the monitoring result.
  • the sleep monitoring module includes a signal measurement sensor, a signal preprocessing unit, and an analysis monitoring unit;
  • the signal measurement sensor is used to collect the physiological signal
  • the signal preprocessing unit is connected to the output terminal of the signal measurement sensor, and is used for amplifying and filtering the physiological signal and converting it into a digital physiological signal;
  • the analysis and monitoring unit is connected to the signal preprocessing unit, and is used to perform feature extraction, feature recognition, and feature classification on the digital physiological signal, and monitor sleep status
  • the sleep control module includes: a micro-current stimulation unit, a light adjustment unit, a somatosensory vibration unit, and a temperature control unit; wherein,
  • the micro-current stimulation unit is used to output current control parameters according to the monitoring result to realize the micro-current stimulation of different regions of the human brain and adjust the sleep state;
  • the light adjusting unit is used for outputting light adjusting parameters according to the monitoring result, and emitting different light;
  • the somatosensory vibration unit is used to output vibration control parameters according to the monitoring result, and emit vibrations of different intensities or frequencies;
  • the temperature control unit is used for outputting temperature control parameters according to the monitoring result to adjust the sleep environment temperature.
  • the signal measurement sensor includes a dry electrode array, and the dry electrode array is used to obtain EEG signals in different sleeping postures.
  • the micro-current stimulation unit includes an over-current protection circuit, and the over-current protection circuit is used to automatically power off when the passing current exceeds a preset threshold.
  • an automatic staging model is provided in the analysis monitoring unit, and the automatic staging model is used to classify the sleep state.
  • the present invention has the following advantages:
  • the present invention proposes a sleep monitoring and control method and device based on human multi-mode signals. Compared with existing methods in the market, it has higher accuracy and scientificity, because EEG signals are recognized by the academic circles at home and abroad for sleep The "gold standard" for state classification.
  • the brain device of the present invention mainly uses EEG signals as the main basis for sleep detection. At the same time, it uses dry electrodes to form an array as a sensor to obtain EEG signals. The user does not need to inject electrode paste and the assistance of specialized personnel.
  • the EEG signal can be monitored on the bed, which is easy to use; and the device can automatically detect the contact state of the user's scalp and the electrode, and select the best two-channel signal for collection, which can ensure that no additional impact on the user is caused, but also Obtain a higher EEG signal
  • the present invention can also collect ECG, EOG, respiration, body temperature, and body movement signals at the same time. It can not only assist in sleep state analysis and regulation, but also be effective for some special users, such as snoring and sudden changes. Monitor apneas, etc., and be able to issue alarms in time;
  • This device can not only detect sleep status and classify sleep quality, but can also use micro-current, light, temperature, somatosensory massage and other methods to implement adjustments to help users improve sleep quality;
  • the analysis and monitoring unit of the present invention adopts a multi-core digital processor, which can select different resources in the multi-core digital processor for processing according to different tasks. Sleep monitoring and control device portability.
  • Fig. 1 is a schematic structural diagram of a sleep monitoring and regulating device based on human multi-mode signals according to the present invention
  • FIG. 2 is a schematic diagram of the distribution of signal measurement sensors and the distribution of sensor state monitoring circuits of the sleep monitoring and regulating device based on human multi-mode signals according to the present invention
  • Fig. 3 is a circuit diagram of the microcontroller of the sleep monitoring and regulating device based on the human body multi-mode signal according to the present invention
  • FIG. 4 is a circuit diagram of the sensor state detection circuit of the sleep monitoring module of the sleep monitoring and regulating device based on the human body multi-mode signal with the microcontroller removed;
  • FIG. 5 is a circuit diagram of the analog signal amplification and filter circuit of the sleep monitoring module of the sleep monitoring and regulating device based on the human multi-mode signal of the present invention
  • FIG. 6 is a circuit diagram of the first analog-to-digital converter of the sleep monitoring module of the sleep monitoring and regulating device based on the human multi-mode signal of the present invention
  • FIG. 7 is a circuit diagram of the analysis and monitoring unit of the sleep monitoring module of the sleep monitoring and regulating device based on human multi-mode signals of the present invention
  • FIG. 8 is a schematic diagram of the structural connection of the sleep control module of the sleep monitoring and control device based on human multi-mode signals according to the present invention.
  • FIG. 9 is a circuit diagram of the signal generator and the constant current source circuit in the micro-current stimulation unit of the sleep control module of the sleep monitoring and control device based on the human multi-mode signal of the present invention
  • FIG. 10 is a circuit diagram of the overcurrent protection circuit in the micro-current stimulation unit of the sleep control module of the sleep monitoring and control device based on the human multi-mode signal of the present invention
  • 11 is a circuit diagram of the emergency mechanical control switch in the micro-current unit stimulation of the sleep control module of the sleep monitoring and control device based on the human multi-mode signal of the present invention
  • FIG. 12 is a circuit diagram of the light adjustment unit of the sleep control module of the sleep monitoring and control device based on human multi-mode signals of the present invention
  • FIG. 13 is a circuit diagram of the somatosensory vibration unit of the sleep control module of the sleep monitoring and control device based on human multi-mode signals of the present invention
  • FIG. 14 is a circuit diagram of the temperature control unit of the sleep control module of the sleep monitoring and control device based on the human body multi-mode signal of the present invention
  • 15 is a flowchart of the automatic sleep staging algorithm of the sleep monitoring and regulating device based on human multi-mode signals of the present invention.
  • FIG. 1 it is a schematic structural diagram of a sleep monitoring and regulating device based on human multi-mode signals according to the present invention. specifically, the device includes:
  • the sleep monitoring module 2 is used to obtain physiological signals, analyze them according to the physiological signals, and monitor the sleep state; among them, the physiological signals include brain electrical signals, electrocardiographic signals, eye electrical signals, respiration signals, body temperature signals, and body movement signals;
  • the sleep monitoring module 2 includes a signal measurement sensor 21, a signal preprocessing unit 22, and an analysis monitoring unit 23;
  • the signal measuring sensor 21 is used to collect physiological signals.
  • the physiological signals at this time are analog signals.
  • the signal measuring sensor 21 in this embodiment includes brain electricity collection electrodes, ECG electrodes, eye electricity electrodes, respiration sensors, body temperature probes, and body movements. Sensors, etc.;
  • the EEG acquisition electrode is a dry electrode array (dry electrode array), used to collect the EEG signals of the user in different sleeping postures (including sleeping on the back, sleeping on the left or right side);
  • the ECG The electrode is attached to the left or right wrist;
  • the EOG electrode is attached to the left or right upper and lower eyelids, the breathing sensor is located under the nostrils, the temperature probe is attached to the forehead, and the body movement sensor is located in the middle area of the bed;
  • the signal preprocessing unit 22 is connected to the output terminal of the signal measurement sensor 21, and is used to amplify and filter the physiological signal and convert it into a digital physiological signal;
  • the signal preprocessing unit 22 includes a sensor state monitoring circuit, an analog signal amplifying and filtering circuit, and a first analog-to-digital converter; the sensor state monitoring circuit transmits the physiological signal obtained by the sensor in good contact with the human body to the analog signal.
  • the amplification and filtering circuit performs signal amplification and filtering circuits to realize the amplification and filtering of analog signals.
  • the first analog-to-digital converter is controlled to convert the analog signals into digital physiological signals,
  • the sensor state monitoring circuit includes a microcontroller 221, a second analog-to-digital converter 222, an impedance conversion module 223, and Channel analog switch 224, first two-channel analog switch 225, second two-channel analog switch 226, first transmitter follower 227, second transmitter follower 228 and resistor R229;
  • the microcontroller 221 is an ordinary microcontroller, and its circuit diagram can refer to Figure 3. It is composed of chip U3A, resistors R45 to R50, resistor RDM1, resistor RDP1, passive crystal oscillator X1, and capacitors C45 to C47; the model of the chip U3A For STM32F102, the resistance values of the resistors R45, R46, RDM1 and RDP1 are all 330 ⁇ , the resistance values of the resistors R47 ⁇ R49 are all 1K ⁇ , the resistance value of the resistor R50 is 10K ⁇ , and the capacitance values of the capacitors C45 and C46 are 22pF , The capacitance value of the capacitor C47 is 104F, and the frequency of the passive crystal oscillator X1 is 8MHz.
  • the chip U3A is connected to one end of the resistor R45 through the pin PA9, and the other end of the resistor R45 is connected to the pins NA1 ⁇ NA8 of the chip U01A of the multi-channel analog switch 224 in FIG. 4; the chip U3A is connected to one end of the resistor R46 through the pin PA10 The other end of the resistor R46 is connected to the control pin IN of the first two-channel analog switch 225 in FIG. 4; the chip U3A is connected to one end of the resistor R47 through the pin PA11, and the other end of the resistor R47 is connected to the second two channels in FIG. The control pin IN of the analog switch 226 is connected.
  • the second analog-to-digital converter 222 uses a chip U4A with the model number ADS8343; this chip U4A is connected to the power supply through pin VCC, grounded through pin GND and pin COM, and connected to chip U3A in Figure 3 through pin DCLK
  • the pin PB0 is connected to the pin PB1 of the chip U3A in Figure 3 through the pin CS
  • the pin PB2 of the chip U3A in Figure 3 is connected through the pin DIN
  • the pin BUSY is connected to the tube of the chip U3A in Figure 3
  • Pin PB5 is connected to pin PB6 of chip U3A in Figure 3 through pin Dout;
  • the impedance conversion module 223 is composed of 27 operational amplifiers U01A connected in parallel.
  • a resistor R1A is connected between the inverting input terminal and the output terminal of each operational amplifier U01A, and the inverting input of each operational amplifier U01A The terminal is connected to each dry electrode in the signal measurement sensor 21;
  • the non-inverting input terminal of each operational amplifier U01A is connected to the pin CH0 of the chip U4A of the second analog-to-digital converter 222, and the positive pole of each operational amplifier U01A is connected to +5V Power supply, the negative pole of each operational amplifier U01A is connected to a -5V power supply;
  • the resistance value of the resistor R1A is 100 ⁇ ;
  • the multi-channel analog switch 224 is composed of a chip U1A and a chip U2A, both models of which are HCC4067; the first two-channel analog switch 225 adopts a chip U03A of the model ADG619, which is connected to the chip U1A of the multi-channel analog switch 224 through pin S1
  • the pin XI0 is connected to the inverting input terminal of the first follower 227 through the pin S2, the resistor R229 is connected to the pin IN, and the 2.5V power supply is connected to the resistor R229; at the same time, the chip U03A is also connected to the pin IN
  • the second two-channel analog switch 226 in this embodiment adopts a chip U04A with a model number of ADG619, which is connected to the reference electrode of the ear clip through a signal line, and is connected to the reverse of the operational amplifier U06A of the second follower 228 through the pin S1.
  • Phase input terminal grounded through pin S2;
  • the first emitter follower 227 is composed of an operational amplifier U05A and a resistor R30 connected between the inverting input terminal and the output terminal of the operational amplifier U05A.
  • the resistance value of the resistor R30 is 100 ⁇ ;
  • the positive electrode of the operational amplifier U05A is connected to + The 5V power supply, the negative pole is connected to the -5V power supply;
  • the second emitter follower 228 is composed of an operational amplifier U06A and a resistor R31 connected between the inverting input terminal and the output terminal of the operational amplifier U06A.
  • the resistance value of the resistor R31 is 100 ⁇ .
  • the operation process of the signal measurement sensor 21 and the sensor state monitoring circuit is: the dry electrode array of the signal measurement sensor 21 measures and monitors the EEG signals of the user under different sleeping positions; the dry electrode in the signal measurement sensor 21 The array is connected to the impedance conversion module 223, wherein each dry electrode in the signal measurement sensor 21 is connected to the inverting input terminal of each operational amplifier U01A in the impedance conversion module 223 to realize impedance conversion; each operational amplifier U01A in the impedance conversion module 223 The converted signal is output to the multi-channel analog switch 224.
  • the pins NA1 ⁇ NA8 of the chip U01A of the multi-channel analog switch 224 receive the control signal output by the microcontroller 221 to realize the output signal for each operational amplifier U01A in the impedance conversion module 223 And then output to the pin S1 of the first two-channel analog switch 225 through the pin XI0 of the multi-channel analog switch 224; the chip U03A of the first two-channel analog switch 225 receives the control signal of the microcontroller 221 through the pin NB , Realize that the pin S1 of the chip U03A of the first two-channel analog switch 225 is connected to the pin S2 or the pin IN of the chip U03A of the first two-channel analog switch 225, which is connected to the pin of the first two-channel analog switch 225 S2 connection means that the channel signal is available.
  • the first transmitter 227 After passing through the first transmitter 227, it is output to the signal input terminal of the operational amplifier U1 of the analog signal amplifying circuit of the analog signal amplifying and filtering circuit 23 in Figure 5, and connected to 2.5V after passing through the resistor R229.
  • the voltage source is used to monitor the contact state of the dry electrode and the brain scalp;
  • the ear clip reference electrode is placed at the earlobe position, and after passing through the second two-channel analog switch 226, the control signal is output through the pin PA11 under the control of the microcontroller 221, and then Output through pin 2 of 226 to the negative input terminal of the second emitter follower 208, and then output through the Vref terminal of 208 to form a differential signal with the electrode in the dry electrode array of the signal measurement sensor 21, and output to analog signal amplification and filtering Circuit;
  • the second two-channel analog switch 226 under the control of the microcontroller 221 realizes that when the pin S1 of the chip U04A is connected to the pin D, it will realize the monitoring
  • the analog signal amplifying and filtering circuit in this embodiment, refer to Figure 5, which is connected to the first analog-to-digital converter and includes an analog signal amplifying circuit and a second-order low-pass filter circuit;
  • the analog signal amplifying circuit consists of operational amplifiers U1 to U3 and Resistor R0 is connected, the model of the operational amplifier U1 and U2 is AD8639, the model of the operational amplifier U3 is AD8424;
  • the non-inverting input terminal of the operational amplifier U1 is the signal input terminal, and the reverse input terminal is connected to the output terminal;
  • the operational amplifier The non-inverting input terminal of U2 is the reference signal input terminal, and the inverting input terminal is connected to the output terminal;
  • the inverting input terminal of the operational amplifier U3 is connected to the output terminal of the operational amplifier U1, and the non-inverting input terminal of the operational amplifier U3 is connected to the operational amplifier
  • the resistor R0 is connected between the non-inverting input terminal
  • the second-order low-pass filter circuit is composed of resistors R1 to R4, capacitors C1 to C2, and an operational amplifier U4.
  • the model of the operational amplifier U4 is AD8639; among them, one end of the resistor R1 is a second-order low-pass
  • the input pin VIN of the filter circuit is connected to the output pin Vout of the operational amplifier U3 in FIG.
  • resistor R1 is connected to the resistor R2 and connected to the inverting input terminal of the operational amplifier U4 through the resistor R2; the resistor R4 One end is grounded, and the other end is connected to the non-inverting input end of the operational amplifier U4; one end of the capacitor C1 is grounded, the other end is connected to the resistor R3 and connected to the output end of the operational amplifier U4 through the resistor R3; one end of the resistor R4 is grounded, and the other end is connected to the operational amplifier U4 The non-inverting input terminal.
  • the first analog-to-digital converter is electrically connected to the analysis and monitoring unit 23, and is composed of an operational amplifier U5, resistors R21 to R24, and an analog-to-digital converter.
  • the model of the operational amplifier U5 is THS4521; the model of the analog-to-digital converter U6 is ADS1278; one end of the resistor R21 is the first analog-to-digital converter input pin Vin and is connected to the output of the operational amplifier U4 in Figure 7
  • the other end of the resistor R21 is connected to the resistor R22 and the negative terminal of the operational amplifier U5 through the resistor R22; one end of the resistor R24 is grounded, and the other end is connected to the inverting input terminal of the operational amplifier U5; one end of the resistor R23 is connected to the operational amplifier U5
  • the inverting input terminal of the amplifier U5, the other end is connected to the positive electrode of the operational amplifier U5; the non-inverting input terminal of the operational amplifier U5 is connected between the resistor R21 and the resistor R22; the analog-to-digital converter U6 is connected to the operational amplifier U5 through the pin AIN_N
  • the negative pole is connected to the output terminal of the operational amplifier U5 through the
  • the analog-to-digital converter U6 converts the filtered and amplified analog EEG signal into a digital signal. Because the analog-to-digital converter U6 is a fully differential input mode, it is necessary to convert a single-ended analog signal to a differential signal, using a single-ended to differential chip THS4521 That is, operational amplifier U5, which realizes single-ended input and differential output;
  • the analysis and monitoring unit 23 is connected to the signal preprocessing unit 22, and is used to perform feature extraction, feature recognition, and feature classification on the digital physiological signal, and monitor the sleep state;
  • the analysis and monitoring unit 23 in this embodiment is a multi-core digital processor (DSP+ARM+FPGA).
  • the analysis and monitoring unit 23 is composed of chip U5A, chip J5, chip S001, resistors RJ4 to RJ13, resistors RJ53 to RJ57, capacitors CC3, and capacitors.
  • the resistance value of the resistor RJ4 is 4.7K ⁇
  • the resistance value of the resistor RJ5, the resistor RJ11, and the resistor RJ13 are all 2K ⁇
  • the resistance value of the resistor RJ6 is 1K ⁇
  • the resistance value of the resistor RJ7 and the resistor RJ8 are both 3K ⁇ .
  • the resistance value of the resistor RJ9 is 22K ⁇
  • the resistance values of the resistors RJ10 and RJ12 are both 4K ⁇
  • the resistance values of the resistors RJ53 ⁇ RJ57 are all 330 ⁇
  • the capacitance values of the capacitor CC3, the capacitors C15 ⁇ C17, and the capacitors C52 ⁇ C53 Both are 104F
  • the capacitance values of the capacitors C18 and C19 are both 24PF
  • the model of the chip U5A is TMS320F2812PGF;
  • connection method is: one end of the resistor RJ9 is grounded to GND, the other end is connected to the pin ADCRESEXT of the chip U5A; one end of the capacitor C52 is grounded to GND, and the other end is connected to the pin ADCREFM of the chip U5A; one end of the capacitor C53 is grounded to GND, and the other end is connected to the pin of the chip U5A ADCREFP; one end of the resistor RJ53 is connected to the power supply VDD33, the other end is connected to the pin XHOLD of the chip U5A; one end of the resistor RJ54 is connected to the power supply VDD33, and the other end is connected to the pin XHOLDA of the chip U5A; one end of the resistor R57 is connected to the power supply VDD33, and the other end is connected to the tube of the chip U5A Pin XREADY; the frequency of the crystal oscillator X2 is 30MHz, one end is connected to the pin X2 of the chip U5A
  • the model of the chip J5 is JTAG and has 14 pins, which are grounded through pin 8 and connected to the pin TDI of chip U5A in FIG. 7 through pin 3, and connected to the chip in FIG. 7 through pin 7 U5A pin TDO; one end of capacitor C15 is connected to resistor RJ4 and connected to pin 1 of chip J5 through resistor RJ4, and the other end of capacitor C15 is connected to resistor RJ6 and connected to pins 9 and 11 of chip J5 through resistor RJ6; One end of the capacitor C16 is grounded, and the other end is connected to the No. 5 pin of the chip J5; one end of the resistor RJ5 is grounded, and the other end is connected to the No.
  • one end of the resistor RJ7 is connected to the power supply VDD33, and the other end is connected to the No. 13 pin of the chip J5;
  • One end of the resistor RJ8 is connected to the power supply VDD33, and the other end is connected to the 14th pin of the chip J5;
  • one end of the capacitor C17 is grounded, and the other end is connected to the power supply VDD33;
  • the model of the chip S001 is SW DIP-2; the chip S001 is connected to the resistor R13 through pin 1 and grounded through the resistor R13; the chip S001 is connected to the resistor R11 through pin 2 and grounded through the resistor R11; S001 is connected to resistor R10 through pin 3 and connected to power source VDD33 through resistor R10; chip S001 is connected to resistor R12 through pin 4 and power source VDD33 through resistor R12; one end of capacitor CC3 is grounded, and the other end is connected to power source VDD33.
  • the sleep control module 3 is signal-connected to the sleep monitoring module 2 and is used for outputting control parameters for regulating the sleep environment according to the monitoring result.
  • the sleep control module 3 in this embodiment includes a micro-current stimulation unit 31, a light adjustment unit 32, a somatosensory vibration unit 33, and a temperature control unit 34; refer to FIG. 8 for the circuit diagram of the sleep control module 3, where,
  • the micro-current stimulation unit 31 is used to output current control parameters according to the monitoring result, realize the micro-current stimulation of different regions of the human brain, and adjust the sleep state;
  • the micro-current stimulation unit 31 is electrically connected to the analysis and monitoring unit 23, and includes a signal generator 311, a constant current source circuit 312, an overcurrent protection circuit 313, and an emergency mechanical control switch 314; the signal input terminal of the signal generator 311 is connected to the analysis and monitoring unit 23 is electrically connected, the signal output terminal is connected to the constant current source circuit 312; the constant current source circuit 312 is electrically connected to the overcurrent protection circuit 313 and the emergency mechanical control switch 314; the output terminal IO of the overcurrent protection circuit 313 is connected to the human body to realize Micro-current stimulation to the human body, and when the passing current exceeds the preset threshold, the power is automatically cut off;
  • the circuit diagram of the signal generator 311 and the constant current source circuit 312 can refer to FIG. 9.
  • the signal generator 311 is composed of a chip DAC1, a capacitor C2, and a capacitor C3;
  • the constant current source circuit 312 is composed of a capacitor C5, a capacitor C6, a capacitor Cp6,
  • the capacitor C8, the resistor R6, the resistor R7, the resistor RdaD1, the resistor R15, and the Zener diode D0 are composed;
  • the model of the Zener diode D0 is SMBJ2.
  • Capacitor C2 Capacitor C3, Capacitor C6, Capacitor C8 have a capacitance value of 104F; Capacitance Cp6 has a capacitance value of 10uF; Resistance R6 has a resistance value of 15 ⁇ , R7 and RdaD1 have zero resistance; resistance R15 has a resistance value 15K ⁇ ;
  • the model of the chip DAC1 is DAC7760, which is grounded to AGND through the pin -VSENSE and the pin DVDD-EN, is connected to the 3.3V power supply through the pin DVDD, is connected to the pin PB0 of the chip U3A in Figure 3 through the pin ALARM, and through the pin LATCH Connect the pin XA2 of the chip U5A of the analysis and monitoring unit 23 in Fig. 7, connect the pin XA3 of the chip U5A of the analysis and monitoring unit 23 in Fig. 7 through the pin SCLK, and connect the pin of the chip U3A in Fig.
  • the circuit diagram of the over-current protection circuit 313 can be referred to as FIG. 10, which is composed of chip U7, resistor R101, resistor R102, resistor Rsense1, resistor Rlimit1, and capacitor C1; the resistance value of resistor R101 is 10K ⁇ , and the resistance R102 is zero resistance.
  • the resistance value of the resistor Rsense1 is 10-100 ⁇ , the resistance value of the resistor Rlimit1 is 20K-23.5K ⁇ ; the capacitance value of the capacitor C1 is 104F;
  • the model of chip U7 is INA301A1, which is connected to a 3.3V power supply through pin VS, connected to pin PB1 of chip U3A in Figure 3 through pin OUT, and connected to pin U3A of chip U3A in Figure 3 through pin ALERT PB10, connect pin PB2 of chip U3A in Figure 3 through pin RESET, connect pin PA5 of chip U3A in Figure 3 through pin LIMIT, and ground AGND through pin GND; this resistor Rsense1 is connected to pin IN+ of chip U7 Between the capacitor C1 and the pin IN-; one end of the capacitor C1 is connected to the pin VS of the chip U7, and the other end is grounded; one end of the resistor R101 is connected to the pin VS of the chip U7, and the other end is connected to the pin ALERT of the chip U7; one end of the resistor Rlimit1 Connect the pin GND of the chip U7, the other end is connected to the resistor R102 and the pin LIMIT of the chip U7 is connected through the
  • the circuit diagram of the emergency mechanical control switch 314 can refer to FIG. 11, which is composed of a transistor Q1, a resistor R100, and a switch S1; the resistance value of the resistor R100 is 1K ⁇ .
  • the transistor Q1 adopts a PNP transistor, its collector is grounded, the base is connected to the pin XA4 of the chip U5A in the analysis and monitoring unit 23 in Figure 7, the emitter is connected to one end of the resistor R100; the other end of the resistor R100 is connected to the switch S1 and passes through the switch S1 Grounded.
  • the light adjustment unit 32 is used to output light adjustment parameters according to the monitoring results, and emit different lights to help people adjust the day and night life rules and other biological effects;
  • the light adjustment unit 32 is electrically connected to the analysis and monitoring unit 23.
  • the light adjustment unit 32 has 6 pins.
  • the No. 1 pin A1 is connected to the chip U5A in the analysis and monitoring unit 23 in FIG.
  • the pins GPIOB0-PWM7 are connected, the second pin A2 is connected to the pins GPIOB1-PWM8 of the chip U5A of the analysis and monitoring unit 23 in Fig. 7, and the third pin IO1 is connected to the chip U5A of the 23 in the analysis and monitoring unit in Fig.
  • the pins GPIOB2-PWM9 are connected, the 4th pin IO2 is connected to the pins GPIOB3-PWM10 of the chip U5A in the analysis and monitoring unit 23 in Fig. 7, and the 5th pin IO3 is connected to the 23’s in the analysis and monitoring unit in Fig. 7
  • the pins GPIOB4-PWM11 of the chip U5A are connected, and the 6th pin IO4 is connected to the pins GPIOB5-PWM12 of the chip U5A 23 in the analysis monitoring unit in FIG. 7.
  • the somatosensory vibration unit 33 is used to output vibration control parameters according to the monitoring results, control the motor to emit vibrations of different intensities or frequencies, and perform somatosensory control;
  • the somatosensory vibration unit 33 is electrically connected to the analysis and monitoring unit 23.
  • the first vibration unit UC1 has pin 1 grounded, and pin 2 is connected to a resistor R01 And connect the power supply VCC through the resistor R01;
  • the No. 1 pin of the second vibration unit UC2 is grounded, the No. 2 pin is connected to the resistor R02 and the power supply VCC through the resistor R02;
  • the No. 1 pin of the third vibration unit UC3 is grounded, and the No.
  • the pin is connected to the resistor R03 and the power supply VCC through the resistor R03; the pin 1 of the fourth vibration unit UC4 is grounded, the pin 2 is connected to the resistor R04 and the power source VCC is connected through the resistor R04; the resistances of the resistors R01 to R04 are all 1K ⁇ .
  • the temperature control unit 34 is configured to output temperature control parameters according to the monitoring result to adjust the sleep environment temperature
  • the temperature control unit 34 is electrically connected to the analysis and monitoring unit 23.
  • the temperature control unit 34 is composed of a temperature sensor T1, electric heaters J1 and J2; the temperature sensor T1's No. 1 pin is Measuring point (that is, the contact point with the human body), the No. 2 pin is a data line and is connected to the pin XA0 of the chip U5A of the analysis and monitoring unit 23 in Fig.
  • one end of the electric heater J1 is grounded to GND, and the other end is a control circuit
  • the signal line of heater J1 is connected to the pins GPIOB6-T3PWM_T3CMP of chip U5A of the analysis and monitoring unit 23; one end of the electric heater J2 is grounded, and the other end is the signal line that controls the operation of the electric heater J2 and is connected to the analysis and monitoring
  • the pins GPIOB7-T4PWM_T4CMP of the chip U5A of the unit 23 are connected.
  • the human body physiological electrical signal is obtained by the signal measurement sensor 21, and then after the sensor state monitoring circuit of the signal preprocessing unit 22, the signal obtained by the sensor in good contact with the human body is transmitted to the analog signal amplifying and filtering circuit to realize the analog signal Amplify and filter, and then, under the control of the analysis and monitoring unit 23, control the first analog-to-digital converter to convert the analog signal into a digital signal (implemented by FPGA core in the analysis and monitoring unit 23), and the analysis and monitoring unit 23 reads the first analog-to-digital After the digital signal output by the converter, the signal is processed, including signal preprocessing, feature extraction, feature recognition, feature classification and other operations to realize sleep state monitoring (implemented by the DSP core in the analysis and monitoring unit 23), and at the same time, the analysis and monitoring unit 23 Real-time display of multi-modal physiological signals and output control parameters (implemented by the ARM core in the analysis and monitoring unit 23); According to the monitoring results of the sleep monitoring module 2, output different parameters, control the functional modules of the sleep control module
  • the micro-current stimulation unit 31 is used to regulate the sleep state: the signal generator 311, such as AD9831, is controlled by the analysis and monitoring unit 23 in FIG. 7 to control the signal generator 311 to output different amplitudes according to different sleep states.
  • the stimulus signal of frequency then the stimulus signal is output to the constant current source circuit 312 for processing, and the required current signal is stably output; at the same time, in order to prevent sudden situations, the current is too large and cause harm to the human body, the current output by the constant current source circuit 312 It will pass through the over-current protection circuit 313. When the current exceeds the set threshold, the circuit will automatically cut off power to effectively protect the human body.
  • the emergency mechanical control switch 314 is adopted.
  • the emergency mechanical control switch 314 can be used to realize the circuit emergency disconnection.
  • this embodiment also provides a monitoring of the contact state of the brain electricity collection electrode (dry electrode) with the brain scalp:
  • the circuit diagram can refer to FIG. 2, the judgment method of the microcontroller 221 when the dry electrode and the scalp contact state are monitored To: Use the second analog-to-digital converter 222 to obtain the voltage value V1 between the 3 pins of the 205 and the 207 connection, and set the resistance value of the 207 to R, then the contact Rz between the dry electrode and the scalp is:
  • the value of R in this embodiment is 10K ⁇ 50K ⁇ , and the value of Rz is obtained according to the above formula.
  • the value of Rz is greater than 100K ⁇ , it is considered that the dry electrode has no contact with the scalp; when the value of Rz is less than or equal to 100K ⁇ , it is considered to be The dry electrode has no contact with the scalp, and the two electrodes with the smallest impedance value are selected at the same time as effective sensors to collect EEG signals;
  • the analysis and monitoring unit 23 is also provided with an automatic staging model, the automatic staging model is used to classify the sleep state, the acquisition of the automatic staging model, that is, the flow chart of the automatic sleep staging algorithm can refer to FIG. 15;
  • an automatic staging method is adopted, that is, the EEG is removed by the IIR Butterworth bandpass filter (0.3Hz-35Hz), and then the signal is performed for 30 seconds without overlapping in the time series. Segment to obtain the staging data frame, and finally add a Hamming window to the segmented data frame to obtain the input space of the entire algorithm; then, for each data frame, the algorithm extracts the time domain features, frequency domain features, and time-frequency features of the EEG separately Features and nonlinear features constitute a 25-dimensional feature space; then the feature space and expert staging markers are used to form a training set as the input of the support vector machine model and the staging model is trained; finally, the classification accuracy and generalization performance of the staging model are tested and selected The model with the best test result is used as the automatic staging model.
  • the device in this embodiment uses EEG signals as the main basis for sleep monitoring.
  • EEG signals as the main basis for sleep monitoring.
  • dry electrodes are used to form an array to obtain EEG signals as sensors.
  • the hardware circuit can automatically monitor the user's scalp and For the electrode contact state, select the best two-channel signal for collection, which can not only ensure no additional impact on the user, but also obtain a higher EEG signal;
  • the hardware circuit of this device is portable.
  • the sleep device recognized by doctors at home and abroad is polysomnography (PSG), but the system is large in size and requires a special computer for data analysis and collection, and requires professionals to use it.
  • this patent uses the analysis and monitoring unit 23 (multi-core processor), such as AM5728, uses FPGA core to realize the control of the analog-to-digital converter, converts the analog signal into digital signal, and then uses the DSP core to realize the signal processing, Including signal preprocessing, feature extraction, feature recognition, feature classification and other operations to achieve sleep monitoring.
  • the DSP core sets the control parameters according to the sleep state monitoring results, and displays multi-modal physiological signals and output control parameters in real time. Get rid of the dependence of traditional computers and realize the portability of the system;
  • the device in this embodiment can not only monitor sleep status and classify sleep quality, but can also implement adjustments in specific ways such as micro-current, light, temperature, and somatosensory massage to help users improve sleep quality.
  • this embodiment also provides a sleep monitoring and control method based on human multi-mode signals, and the method includes the following steps:
  • S1 Collect physiological signals
  • Physiological signals include brain electrical signals, electrocardiographic signals, eye electrical signals, respiration signals, body temperature signals and body movement signals;
  • the EEG signals of the user under different sleeping positions are measured and monitored by the dry electrode array
  • the step of evaluating the sleep state and sleep stage in this step specifically includes:
  • S22 Segment the EEG signal after artifact removal according to the first preset time period, and add a Hamming window to the segmented data to obtain an input space;
  • S25 Test the classification accuracy and generalization performance of the staging model and select the model with the best test result as the automatic staging model.
  • S3 Regulate the sleep environment according to the monitoring structure.
  • S31 Output current control parameters according to the monitoring results to achieve micro-current stimulation of different areas of the human brain and adjust sleep state;
  • a protection method is also provided, specifically, a threshold is set in advance at the same time.
  • the circuit is automatically powered off to effectively protect the human body;
  • the threshold is the human body can withstand, and Within the current range that will not cause physical harm;

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Abstract

A monitoring and regulation method and apparatus based on a human body multimode signal. The apparatus comprises a sleep regulation bed (1), and a sleep monitoring module (2) and a sleep regulation module (3) that are disposed on the sleep regulation bed (1). The sleep monitoring module (2) is used for obtaining physiological signals and performing analysis according to the physiological signals to monitor a sleep state, wherein the physiological signals comprise an electroencephalogram signal, an electrocardiogram signal, an electrooculogram signal, a respiration signal, a body temperature signal, and a body movement signal; the sleep regulation module (3) is in signal connection with the sleep monitoring module (2) and is used for outputting, according to the monitoring result, regulation parameters for regulating a sleep environment. The apparatus can not only detect the sleep state and classify the sleep quality, but can also implement regulation by targeted means such as micro current, light, temperature, and somatosensory massage, so as to help a user improve the sleep quality.

Description

基于人体多模信号的睡眠监测调控方法及装置Sleep monitoring and regulating method and device based on human body multi-mode signal 技术领域Technical field
本发明属于睡眠监测技术领域,具体涉及一种基于人体多模信号的睡眠监测调控方法及装置。The invention belongs to the technical field of sleep monitoring, and specifically relates to a sleep monitoring and regulation method and device based on human multi-mode signals.
背景技术Background technique
根据世界卫生组织调查,全世界范围内约有三分之一的人存在睡眠问题,而睡眠不足不仅会损害个人的健康与幸福,对国家的经济也会造成重大影响,其中睡眠不足产生的最严重问题是:增加死亡风险。自《时代》周刊的报告显示,与每晚平均睡眠时间达到7-9小时的人相比,每晚睡眠时间不足6小时的人死亡率要比前者高13%,比每晚睡眠时间在6-7小时的人高7%。According to a survey by the World Health Organization, about one-third of people worldwide have sleep problems. Insufficient sleep not only harms personal health and happiness, but also has a major impact on the country’s economy. Among them, lack of sleep causes the most The serious problem is: increase the risk of death. A report from Time magazine shows that compared with people who sleep less than 6 hours a night, the death rate of people who sleep less than 6 hours a night is 13% higher than that of people who sleep 6 hours a night. -7 hours are 7% higher.
随着经济水平发展,以及个人对睡眠问题认识,越来越多的人开始选择睡眠辅助产品帮助睡眠。当前调节睡眠的常用手段有药品、保健品及改善睡眠器械,但长时间的食用药品和保健品,可能会引起药物依赖、人体内激素失调等副作用,因此非入侵式的电子类辅助睡眠逐渐受到人们的青睐。With the development of the economy and personal awareness of sleep problems, more and more people have begun to choose sleep aid products to help sleep. Currently, the commonly used methods for regulating sleep include drugs, health products and sleep-improving devices. However, long-term consumption of drugs and health products may cause side effects such as drug dependence and hormone imbalance in the human body. Therefore, non-invasive electronic assisted sleep is gradually affected. People's favor.
目前很多研究者提供了一些监测睡眠的方法,被广泛认为的睡眠状态监测评价系统为专用的多导睡眠监测系统(polysomnography,PSG),但该系统体积大,需要专门的电脑进行数据分析采集,而且使用时需要专业人员帮助才能使用,如专利CN 108992040A文件中根据加速度传感器活动人体的睡眠动作值和动作频次,并以此为依据判断睡眠状态,但这个方法也存在两个问题:1、该结果只能作为参考数据,可信度低,不能作为医学上监测睡眠依据,比如当使用者静止躺在床上发呆时,该发明无法判断使用者是睡眠还是清醒;2、该专利无法对睡眠层次进行有效划分,只能做统计学的估算;At present, many researchers have provided some methods for monitoring sleep. The sleep state monitoring and evaluation system is widely regarded as a dedicated polysomnography (PSG), but the system is large in size and requires a dedicated computer for data analysis and collection. Moreover, it requires professional help to use it. For example, according to the patent CN 108992040A, the sleep action value and action frequency of the human body are activated by the acceleration sensor, and the sleep state is judged based on this. However, this method also has two problems: 1. The results can only be used as reference data, with low credibility, and cannot be used as a basis for medical monitoring of sleep. For example, when the user is lying still in bed in a daze, the invention cannot determine whether the user is asleep or awake; 2. The patent cannot determine the level of sleep. For effective division, only statistical estimation can be made;
专利CN 109009149 A文件中根据腹腔收缩来评判人的生理状态,其特点在于自动驱动系统工作,但存在的问题是:该发明功能单一,只能通过监测呼吸信号,对高危人群进行睡眠监测,无法对睡眠质量进行分类评判;且该发明中数据需要发送到专门的终端中进行处理,无法体现实时性;The patent CN 109009149 A document judges the human's physiological state based on the contraction of the abdominal cavity. It is characterized by the automatic driving system. However, the problem is that the invention has a single function and can only monitor the breathing signal to monitor the sleep of high-risk groups. Classify and judge sleep quality; and the data in this invention needs to be sent to a special terminal for processing, which cannot reflect real-time performance;
专利文件CN109222961A文件则根据心电、呼吸信号对睡眠质量进行评判,具有一定的科学依据,但在实际应用中存在一些问题,比如该专利获得睡眠质量评判的准确率较低,在文章“Multimodal information improves the rapid detection of mental fatigue”研究指出,脑电信号是睡眠质量评价的“黄金标准”,准确率可以达到95%以上,而心电等其它生理信号评价睡眠质量的准确率低于85%;The patent document CN109222961A judges sleep quality based on ECG and respiratory signals. It has a certain scientific basis, but there are some problems in practical applications. For example, the accuracy of the patent’s sleep quality evaluation is low. In the article "Multimodal information" Improve the rapid detection of mental fatigue" research pointed out that EEG signals are the "gold standard" for sleep quality evaluation, with an accuracy rate of over 95%, while the accuracy rate of other physiological signals such as ECG for evaluating sleep quality is less than 85%;
专利文件CN 109350016A同样是通过对心电、呼吸信号对睡眠质量进行评判,与CN109222961 A相比较,只是采用了无线反射的方法获得这些信号,也存在分类准确率低的问题,而且该发明重点在于睡眠分类方法,但该方面相对简单,只是经过简单预处理后,进行FFT变化,对数据特征选择不明显;The patent document CN109350016A also evaluates the quality of sleep through the ECG and respiratory signals. Compared with CN109222961A, it only uses the wireless reflection method to obtain these signals. There is also the problem of low classification accuracy, and the focus of the invention is Sleep classification method, but this aspect is relatively simple, just after a simple pre-processing, FFT changes, the selection of data features is not obvious;
文件CN109480787A是专利CN109350016A的升级和改进,采用雷达波的方式获得心电、呼吸信号,该方法相对专利CN109350016A,虽然在一定程度提高了睡眠质量评价的准确率,但也存在以下问题:一没有采用脑电作为睡眠质量评价的核心,其结果无法得到医疗领域的认可;二则是雷达属于电磁辐射,对人体存在一定安全隐患;三是数据的分析处理,需要专门的计算机,使用不方便,成本较高。Document CN109480787A is an upgrade and improvement of patent CN109350016A. It uses radar waves to obtain ECG and respiration signals. Compared with patent CN109350016A, this method improves the accuracy of sleep quality evaluation to a certain extent, but it also has the following problems: As the core of sleep quality evaluation, the results of EEG cannot be recognized in the medical field; the second is that radar is electromagnetic radiation, which poses a certain safety risk to the human body; the third is the analysis and processing of data, which requires a special computer, which is inconvenient and costly. Higher.
发明内容Summary of the invention
有鉴于此,本发明的目的之一在于提供一种基于人体多模信号的睡眠监测调控方法,该方法能快速对睡眠进行监测,并根据监测结果对睡眠环境进行调控。In view of this, one of the objectives of the present invention is to provide a sleep monitoring and regulation method based on human multi-mode signals, which can quickly monitor sleep and regulate the sleep environment according to the monitoring results.
为实现上述目的,本发明的技术方案为:一种基于人体多模信号的睡眠监测调控方法,包括以下步骤:In order to achieve the above objective, the technical solution of the present invention is: a sleep monitoring and control method based on human multi-mode signals, including the following steps:
采集生理信号;所述生理信号包括脑电信号、心电信号、眼电信号、呼吸信号、体温信号和体动信号;Collect physiological signals; the physiological signals include brain electrical signals, electrocardiographic signals, eye electrical signals, respiration signals, body temperature signals, and body movement signals;
对所述生理信号进行分析,对睡眠状态进行监测:使用所述脑电信号、所述眼电信号、所述体动信号对睡眠状态、睡眠分期进行评价,使用所述心电信号、所述呼吸信号用于监测使用者身体状态,使用所述体温信号用于监测体温的变化;Analyze the physiological signals and monitor the sleep state: use the brain electrical signal, the eye electrical signal, and the body movement signal to evaluate the sleep state and sleep stage, use the electrocardiographic signal, the The breathing signal is used to monitor the physical state of the user, and the body temperature signal is used to monitor changes in body temperature;
根据监测结构调控睡眠环境。Regulate the sleep environment according to the monitoring structure.
进一步地,所述对睡眠状态、睡眠分期进行评价的步骤具体包括:Further, the step of evaluating the sleep state and sleep stage specifically includes:
采用自动分期法将所述脑电信号进行伪迹去除;Using an automatic staging method to remove artifacts from the EEG signal;
按照第一预设时间段对去除伪迹后的脑电信号分段,并对分段后的数据加Hamming窗,得到输入空间;Segment the EEG signal after artifact removal according to the first preset time period, and add a Hamming window to the segmented data to obtain the input space;
针对每段数据帧,分别提取时域特征、频域特征、时频特征及非线性特征构成25维特征空间;For each data frame, extract time-domain features, frequency-domain features, time-frequency features, and nonlinear features to form a 25-dimensional feature space;
将所述特征空间及常用分期标记组成训练集作为支持向量机模型的输入并训练分期模型;Using the feature space and common staging markers to form a training set as the input of the support vector machine model, and training the staging model;
对所述分期模型的分类准确性和泛化性能进行测试并选择测试结果最优的模型作为自动分期模型。The classification accuracy and generalization performance of the staging model are tested, and the model with the best test result is selected as the automatic staging model.
进一步地,所述根据监测结构调控睡眠环境的步骤具体包括:根据监测结果输出电流调控参数,实现对人脑不同区域的微电流刺激,调整睡眠状态;Further, the step of regulating the sleep environment according to the monitoring structure specifically includes: outputting current control parameters according to the monitoring result, so as to realize the micro-current stimulation to different regions of the human brain and adjust the sleep state;
根据监测结果输出光线调控参数,发出不同的光线;According to the monitoring results, output light control parameters and emit different lights;
根据监测结果输出震动调控参数,发出不同强度或频率的震动;Output vibration control parameters according to the monitoring results, and send out vibrations of different intensities or frequencies;
根据监测结果输出温度调控参数调整睡眠环境温度。According to the monitoring results, the temperature control parameters are output to adjust the sleep environment temperature.
进一步地,通过干式电极阵列采集不同睡眠姿势时的脑电信号。Further, the EEG signals of different sleeping postures are collected through the dry electrode array.
本发明的目的之二在于提供一种基于人体多模信号的睡眠监测调控装置,该装置能够检测睡眠状态,对睡眠质量进行分类,而且能够针对性的采用微电流、光、温度、体感按摩等方式进行实施调控,帮助使用者提高睡眠质量。The second objective of the present invention is to provide a sleep monitoring and control device based on human multi-mode signals, which can detect sleep status, classify sleep quality, and can specifically use micro current, light, temperature, somatosensory massage, etc. Ways to implement regulation to help users improve sleep quality.
为实现上述目的,本发明的技术方案为:一种基于人体多模信号的睡眠监测调控装置,包括睡眠调控床,以及设置在所述睡眠调控床上的睡眠监测模块、睡眠调控模块;To achieve the above objective, the technical solution of the present invention is: a sleep monitoring and regulating device based on human multi-mode signals, including a sleep regulating bed, and a sleep monitoring module and a sleep regulating module arranged on the sleep regulating bed;
所述睡眠监测模块用于获取生理信号,并根据所述生理信号进行分析,对睡眠状态进行监测;其中,所述生理信号包括脑电信号、心电信号、眼电信号、呼吸信号、体温信号和体动信号;The sleep monitoring module is used to obtain physiological signals and analyze them according to the physiological signals to monitor the sleep state; wherein, the physiological signals include brain electrical signals, electrocardiographic signals, eye electrical signals, respiration signals, body temperature signals And body movement signals;
所述睡眠调控模块与所述睡眠监测模块信号相连,用于根据监测结果,输出用于对睡眠环境进行调控的调控参数。The sleep control module is signal-connected with the sleep monitoring module, and is used for outputting control parameters for regulating the sleep environment according to the monitoring result.
进一步地,所述睡眠监测模块包括信号测量传感器、信号预处理单元、分析监测单元;Further, the sleep monitoring module includes a signal measurement sensor, a signal preprocessing unit, and an analysis monitoring unit;
所述信号测量传感器用于采集所述生理信号;The signal measurement sensor is used to collect the physiological signal;
所述信号预处理单元与所述信号测量传感器的输出端相连,用于将所述生理信号进行放大与滤波后转换为数字生理信号;The signal preprocessing unit is connected to the output terminal of the signal measurement sensor, and is used for amplifying and filtering the physiological signal and converting it into a digital physiological signal;
所述分析监测单元与所述信号预处理单元相连,用于对所述数字生理信号进行特征提取、特征识别、特征分类,对睡眠状态进行监测The analysis and monitoring unit is connected to the signal preprocessing unit, and is used to perform feature extraction, feature recognition, and feature classification on the digital physiological signal, and monitor sleep status
进一步地,所述睡眠调控模块包括:微电流刺激单元、光线调节单元、体感震动单元、温度控制单元;其中,Further, the sleep control module includes: a micro-current stimulation unit, a light adjustment unit, a somatosensory vibration unit, and a temperature control unit; wherein,
所述微电流刺激单元用于根据监测结果输出电流调控参数,实现对人脑不同区域的微电流刺激,调整睡眠状态;The micro-current stimulation unit is used to output current control parameters according to the monitoring result to realize the micro-current stimulation of different regions of the human brain and adjust the sleep state;
所述光线调节单元用于根据监测结果输出光线调控参数,发出不同的光线;The light adjusting unit is used for outputting light adjusting parameters according to the monitoring result, and emitting different light;
所述体感震动单元用于根据监测结果输出震动调控参数,发出不同强度或频率的震动;The somatosensory vibration unit is used to output vibration control parameters according to the monitoring result, and emit vibrations of different intensities or frequencies;
温度控制单元用于根据监测结果输出温度调控参数调整睡眠环境温度。The temperature control unit is used for outputting temperature control parameters according to the monitoring result to adjust the sleep environment temperature.
进一步地,所述信号测量传感器包括干式电极阵列,所述干式电极阵列用于获取不同睡眠姿势下的脑电信号。Further, the signal measurement sensor includes a dry electrode array, and the dry electrode array is used to obtain EEG signals in different sleeping postures.
进一步地,所述微电流刺激单元包括过流保护电路,所述过流保护电路用于当经过电流超过预设阈值时,自动断电。Further, the micro-current stimulation unit includes an over-current protection circuit, and the over-current protection circuit is used to automatically power off when the passing current exceeds a preset threshold.
进一步地,所述分析监测单元内设置有自动分期模型,所述自动分期模型用于对睡眠状态分类。Further, an automatic staging model is provided in the analysis monitoring unit, and the automatic staging model is used to classify the sleep state.
与现有技术相比,本发明具有如下优点:Compared with the prior art, the present invention has the following advantages:
(1)本发明提出了基于人体多模信号的睡眠监测调控方法及装置,与市场已有方法相比,具有更高的准确度和科学性,因为脑电信号是国内外学术界公认的睡眠状态分类的“黄金标准”。(1) The present invention proposes a sleep monitoring and control method and device based on human multi-mode signals. Compared with existing methods in the market, it has higher accuracy and scientificity, because EEG signals are recognized by the academic circles at home and abroad for sleep The "gold standard" for state classification.
(2)本发明脑装置以脑电信号为主,作为睡眠检测的主要依据,同时以干电极组成阵列,作为传感器获得脑电信号,使用者不需要注射电极膏和专门人员的辅助帮忙,躺在床上即可实现脑电信号的监测,使用方便;且装置能够自动检测使用者头皮与电极接触状态,选择接触最好的两通道信号进行采集,既能保证不对使用者造成额外影响,又能获得较高的脑电信号(2) The brain device of the present invention mainly uses EEG signals as the main basis for sleep detection. At the same time, it uses dry electrodes to form an array as a sensor to obtain EEG signals. The user does not need to inject electrode paste and the assistance of specialized personnel. The EEG signal can be monitored on the bed, which is easy to use; and the device can automatically detect the contact state of the user's scalp and the electrode, and select the best two-channel signal for collection, which can ensure that no additional impact on the user is caused, but also Obtain a higher EEG signal
(3)本发明除了采集脑电信号外,还可以同时采集心电、眼电、呼吸、体温和体动信号,不仅能够辅助睡眠状态分析和调控,而且能够对一些特殊使用者,比如打鼾、突发呼吸暂停等进行监测,并能够及时发出警报;(3) In addition to collecting EEG signals, the present invention can also collect ECG, EOG, respiration, body temperature, and body movement signals at the same time. It can not only assist in sleep state analysis and regulation, but also be effective for some special users, such as snoring and sudden changes. Monitor apneas, etc., and be able to issue alarms in time;
(4)本装置不仅能够检测睡眠状态对睡眠质量进行分类,还能针对性的采用微电流、光、温度、体感按摩等方式进行实施调控,帮助使用者提高睡眠质量;(4) This device can not only detect sleep status and classify sleep quality, but can also use micro-current, light, temperature, somatosensory massage and other methods to implement adjustments to help users improve sleep quality;
(5)本发明的分析监测单元采用多核数字处理器,能够根据不同任务,选择多核数字处理器中不同资源进行处理,脱离传统电脑计算处理的方式,实现设备的可穿戴和低成本,实现了睡眠监测、调控装置的便携性。(5) The analysis and monitoring unit of the present invention adopts a multi-core digital processor, which can select different resources in the multi-core digital processor for processing according to different tasks. Sleep monitoring and control device portability.
附图说明Description of the drawings
为了更清楚地说明本发明实施例或现有技术中的技术方案,下面将对实施例或现有技术描述中所需要使用的附图作一简单地介绍。显而易见地,下面描述中的附图是本发明的一些实施例,对于本领域普通技术人员来讲,在不付出创造性劳动性的前提下,还可以根据这些附图获得其它的附图。In order to explain the embodiments of the present invention or the technical solutions in the prior art more clearly, the following will briefly introduce the drawings that need to be used in the description of the embodiments or the prior art. Obviously, the drawings in the following description are some embodiments of the present invention. For those of ordinary skill in the art, other drawings can be obtained based on these drawings without creative labor.
图1为本发明基于人体多模信号的睡眠监测调控装置的结构原理图;Fig. 1 is a schematic structural diagram of a sleep monitoring and regulating device based on human multi-mode signals according to the present invention;
图2为本发明基于人体多模信号的睡眠监测调控装置的信号测量传感器分布及传感器状态监测电路分布原理图;2 is a schematic diagram of the distribution of signal measurement sensors and the distribution of sensor state monitoring circuits of the sleep monitoring and regulating device based on human multi-mode signals according to the present invention;
图3为本发明基于人体多模信号的睡眠监测调控装置的微控制器的电路图;Fig. 3 is a circuit diagram of the microcontroller of the sleep monitoring and regulating device based on the human body multi-mode signal according to the present invention;
图4为本发明基于人体多模信号的睡眠监测调控装置的睡眠监测模块的传 感器状态检测电路去掉微控制器后的电路图;4 is a circuit diagram of the sensor state detection circuit of the sleep monitoring module of the sleep monitoring and regulating device based on the human body multi-mode signal with the microcontroller removed;
图5为本发明基于人体多模信号的睡眠监测调控装置的睡眠监测模块的模拟信号放大及滤波电路的电路图;5 is a circuit diagram of the analog signal amplification and filter circuit of the sleep monitoring module of the sleep monitoring and regulating device based on the human multi-mode signal of the present invention;
图6为本发明基于人体多模信号的睡眠监测调控装置的睡眠监测模块的第一模数转换器的电路图;6 is a circuit diagram of the first analog-to-digital converter of the sleep monitoring module of the sleep monitoring and regulating device based on the human multi-mode signal of the present invention;
图7为本发明基于人体多模信号的睡眠监测调控装置的睡眠监测模块的分析监测单元的电路图;7 is a circuit diagram of the analysis and monitoring unit of the sleep monitoring module of the sleep monitoring and regulating device based on human multi-mode signals of the present invention;
图8为本发明基于人体多模信号的睡眠监测调控装置的睡眠调控模块的结构连接原理图;8 is a schematic diagram of the structural connection of the sleep control module of the sleep monitoring and control device based on human multi-mode signals according to the present invention;
图9为本发明基于人体多模信号的睡眠监测调控装置的睡眠调控模块的微电流刺激单元中信号生成器和恒流源电路的电路图;9 is a circuit diagram of the signal generator and the constant current source circuit in the micro-current stimulation unit of the sleep control module of the sleep monitoring and control device based on the human multi-mode signal of the present invention;
图10为本发明基于人体多模信号的睡眠监测调控装置的睡眠调控模块的微电流刺激单元中的过流保护电路的电路图;10 is a circuit diagram of the overcurrent protection circuit in the micro-current stimulation unit of the sleep control module of the sleep monitoring and control device based on the human multi-mode signal of the present invention;
图11为本发明基于人体多模信号的睡眠监测调控装置的睡眠调控模块的微电流单元刺激中的紧急机械控制开关的电路图;11 is a circuit diagram of the emergency mechanical control switch in the micro-current unit stimulation of the sleep control module of the sleep monitoring and control device based on the human multi-mode signal of the present invention;
图12为本发明基于人体多模信号的睡眠监测调控装置的睡眠调控模块的光线调节单元的电路图;12 is a circuit diagram of the light adjustment unit of the sleep control module of the sleep monitoring and control device based on human multi-mode signals of the present invention;
图13为本发明基于人体多模信号的睡眠监测调控装置的睡眠调控模块的体感震动单元的电路图;13 is a circuit diagram of the somatosensory vibration unit of the sleep control module of the sleep monitoring and control device based on human multi-mode signals of the present invention;
图14为本发明基于人体多模信号的睡眠监测调控装置的睡眠调控模块的温度控制单元的电路图;14 is a circuit diagram of the temperature control unit of the sleep control module of the sleep monitoring and control device based on the human body multi-mode signal of the present invention;
图15为本发明基于人体多模信号的睡眠监测调控装置的睡眠自动分期算法流程图。15 is a flowchart of the automatic sleep staging algorithm of the sleep monitoring and regulating device based on human multi-mode signals of the present invention.
具体实施方式Detailed ways
为使本发明实施例的目的、技术方案和优点更加清楚,下面将结合本发明实施例中的附图,对本发明实施例中的技术方案进行清楚、完整地描述。显然,所描述的实施例是本发明一部分实施例,而不是全部的实施例。基于本发明中的实施例,本领域普通技术人员在没有作出创造性劳动前提下所获得的所有其他实施例,都属于本发明保护的范围。In order to make the objectives, technical solutions, and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be described clearly and completely in conjunction with the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are part of the embodiments of the present invention, rather than all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without creative work shall fall within the protection scope of the present invention.
实施例1Example 1
参考图1,为本发明一种基于人体多模信号的睡眠监测调控装置的结构示意图;具体地,该装置包括:Referring to FIG. 1, it is a schematic structural diagram of a sleep monitoring and regulating device based on human multi-mode signals according to the present invention; specifically, the device includes:
睡眠调控床1,设置在睡眠调控床1上的睡眠监测模块2、睡眠调控模块3; Sleep control bed 1, sleep monitoring module 2, and sleep control module 3 arranged on sleep control bed 1;
睡眠监测模块2用于获取生理信号,并根据生理信号进行分析,对睡眠状态进行监测;其中,生理信号包括脑电信号、心电信号、眼电信号、呼吸信号、体温信号和体动信号;The sleep monitoring module 2 is used to obtain physiological signals, analyze them according to the physiological signals, and monitor the sleep state; among them, the physiological signals include brain electrical signals, electrocardiographic signals, eye electrical signals, respiration signals, body temperature signals, and body movement signals;
睡眠监测模块2包括信号测量传感器21、信号预处理单元22、分析监测单元23;The sleep monitoring module 2 includes a signal measurement sensor 21, a signal preprocessing unit 22, and an analysis monitoring unit 23;
信号测量传感器21用于采集生理信号,此时的生理信号为模拟信号,本实施例中的信号测量传感器21包括脑电采集电极、心电电极、眼电电极、呼吸传感器、体温探头和体动传感器等;该脑电采集电极为干式电极阵列(干电极阵列),用于采集使用者不同睡眠姿势(包括仰睡、左侧或右侧的侧睡)时的脑电信号;该心电电极贴在左手或右手手腕处;该眼电电极贴在左侧或右侧上下眼睑处,该呼吸传感器位于鼻孔下方,该体温探头贴在额头部位,该体动传感器位于床的中 间区域;The signal measuring sensor 21 is used to collect physiological signals. The physiological signals at this time are analog signals. The signal measuring sensor 21 in this embodiment includes brain electricity collection electrodes, ECG electrodes, eye electricity electrodes, respiration sensors, body temperature probes, and body movements. Sensors, etc.; the EEG acquisition electrode is a dry electrode array (dry electrode array), used to collect the EEG signals of the user in different sleeping postures (including sleeping on the back, sleeping on the left or right side); the ECG The electrode is attached to the left or right wrist; the EOG electrode is attached to the left or right upper and lower eyelids, the breathing sensor is located under the nostrils, the temperature probe is attached to the forehead, and the body movement sensor is located in the middle area of the bed;
信号预处理单元22与信号测量传感器21的输出端相连,用于将生理信号进行放大与滤波后转换为数字生理信号;The signal preprocessing unit 22 is connected to the output terminal of the signal measurement sensor 21, and is used to amplify and filter the physiological signal and convert it into a digital physiological signal;
本实施例中,信号预处理单元22包括传感器状态监测电路、模拟信号放大及滤波电路、第一模数转换器;传感器状态监测电路将与人体接触状态良好的传感器获得的生理信号传输至模拟信号放大及滤波电路进行信号放大、滤波电路,实现对模拟信号的放大和滤波,接着在分析监测单元23的控制下,控制第一模数转换器将模拟信号转换为数字生理信号,In this embodiment, the signal preprocessing unit 22 includes a sensor state monitoring circuit, an analog signal amplifying and filtering circuit, and a first analog-to-digital converter; the sensor state monitoring circuit transmits the physiological signal obtained by the sensor in good contact with the human body to the analog signal The amplification and filtering circuit performs signal amplification and filtering circuits to realize the amplification and filtering of analog signals. Then, under the control of the analysis and monitoring unit 23, the first analog-to-digital converter is controlled to convert the analog signals into digital physiological signals,
本实施例中的信号测量传感器21分布及传感器状态监测电路分布原理图可参考图2,具体为:传感器状态监测电路包括微控制器221、第二模数转换器222、阻抗转换模块223、多通道模拟开关224、第一两通道模拟开关225、第二两通道模拟开关226、第一射随器227、第二射随器228和电阻R229;For the signal measurement sensor 21 distribution and sensor state monitoring circuit distribution principle diagram in this embodiment, refer to FIG. 2. Specifically, the sensor state monitoring circuit includes a microcontroller 221, a second analog-to-digital converter 222, an impedance conversion module 223, and Channel analog switch 224, first two-channel analog switch 225, second two-channel analog switch 226, first transmitter follower 227, second transmitter follower 228 and resistor R229;
其中,微控制器221是普通微控制器,其电路图可参考图3,由芯片U3A、电阻R45~R50、电阻RDM1、电阻RDP1、无源晶振X1、电容C45~C47组成;该芯片U3A的型号为STM32F102,该电阻R45、R46、RDM1和RDP1的电阻值均为330Ω,该电阻R47~R49的电阻值均为1KΩ,该电阻R50的电阻值为10KΩ,该电容C45和C46的电容值为22pF,该电容C47的电容值为104F,无源晶振X1的频率为8MHz。该芯片U3A通过管脚PA9连接电阻R45的一端,该电阻R45另一端与图4中多通道模拟开关224的芯片U01A的管脚NA1~NA8连接;该芯片U3A通过管脚PA10连接电阻R46的一端,该电阻R46另一端与图4中该第一两通道模拟开关225的控制管脚IN连接;该芯片U3A通过管脚PA11连接电阻R47的一端,电阻R47另一端与图2中第二两通道模拟开关226的控制管脚IN连接。Among them, the microcontroller 221 is an ordinary microcontroller, and its circuit diagram can refer to Figure 3. It is composed of chip U3A, resistors R45 to R50, resistor RDM1, resistor RDP1, passive crystal oscillator X1, and capacitors C45 to C47; the model of the chip U3A For STM32F102, the resistance values of the resistors R45, R46, RDM1 and RDP1 are all 330Ω, the resistance values of the resistors R47~R49 are all 1KΩ, the resistance value of the resistor R50 is 10KΩ, and the capacitance values of the capacitors C45 and C46 are 22pF , The capacitance value of the capacitor C47 is 104F, and the frequency of the passive crystal oscillator X1 is 8MHz. The chip U3A is connected to one end of the resistor R45 through the pin PA9, and the other end of the resistor R45 is connected to the pins NA1~NA8 of the chip U01A of the multi-channel analog switch 224 in FIG. 4; the chip U3A is connected to one end of the resistor R46 through the pin PA10 The other end of the resistor R46 is connected to the control pin IN of the first two-channel analog switch 225 in FIG. 4; the chip U3A is connected to one end of the resistor R47 through the pin PA11, and the other end of the resistor R47 is connected to the second two channels in FIG. The control pin IN of the analog switch 226 is connected.
参考图4,第二模数转换器222采用型号为ADS8343的芯片U4A;该芯片U4A通过管脚VCC连接电源,通过管脚GND和管脚COM接地,通过管脚DCLK连接图3中的芯片U3A的管脚PB0,通过管脚CS连接图3中的芯片U3A的管脚PB1,通过管脚DIN连接图3中的芯片U3A的管脚PB2,通过管脚BUSY连接图3中的芯片U3A的管脚PB5,通过管脚Dout连接图3中的芯片U3A的管脚PB6;Referring to Figure 4, the second analog-to-digital converter 222 uses a chip U4A with the model number ADS8343; this chip U4A is connected to the power supply through pin VCC, grounded through pin GND and pin COM, and connected to chip U3A in Figure 3 through pin DCLK The pin PB0 is connected to the pin PB1 of the chip U3A in Figure 3 through the pin CS, the pin PB2 of the chip U3A in Figure 3 is connected through the pin DIN, and the pin BUSY is connected to the tube of the chip U3A in Figure 3 Pin PB5 is connected to pin PB6 of chip U3A in Figure 3 through pin Dout;
在一实施例中,阻抗转换模块223由27个并联的运算放大器U01A组成,每个运算放大器U01A的反相输入端与输出端之间均连接有电阻R1A,每个运算放大器U01A的反相输入端与信号测量传感器21中的每一个干电极连接;每个运算放大器U01A的同相输入端连接第二模数转换器222的芯片U4A的管脚CH0连接,每个运算放大器U01A的正极连接+5V电源,每个运算放大器U01A的负极连接-5V电源;电阻R1A的电阻值为100Ω;In one embodiment, the impedance conversion module 223 is composed of 27 operational amplifiers U01A connected in parallel. A resistor R1A is connected between the inverting input terminal and the output terminal of each operational amplifier U01A, and the inverting input of each operational amplifier U01A The terminal is connected to each dry electrode in the signal measurement sensor 21; the non-inverting input terminal of each operational amplifier U01A is connected to the pin CH0 of the chip U4A of the second analog-to-digital converter 222, and the positive pole of each operational amplifier U01A is connected to +5V Power supply, the negative pole of each operational amplifier U01A is connected to a -5V power supply; the resistance value of the resistor R1A is 100Ω;
优选地,多通道模拟开关224由型号均为HCC4067的芯片U1A和芯片U2A组成;第一两通道模拟开关225采用型号为ADG619的芯片U03A,其通过管脚S1连接多通道模拟开关224的芯片U1A的管脚XI0连接,通过管脚S2连接第一跟随器227的反相输入端,通过管脚IN连接电阻R229并通过电阻R229连接2.5V电源;同时,该芯片U03A还通过管脚IN连接该第二模数转换器222的芯片U4A的管脚CHO;Preferably, the multi-channel analog switch 224 is composed of a chip U1A and a chip U2A, both models of which are HCC4067; the first two-channel analog switch 225 adopts a chip U03A of the model ADG619, which is connected to the chip U1A of the multi-channel analog switch 224 through pin S1 The pin XI0 is connected to the inverting input terminal of the first follower 227 through the pin S2, the resistor R229 is connected to the pin IN, and the 2.5V power supply is connected to the resistor R229; at the same time, the chip U03A is also connected to the pin IN The pin CHO of the chip U4A of the second analog-to-digital converter 222;
进一步地,本实施例中的第二两通道模拟开关226采用型号为ADG619的芯片U04A,其通过信号线与耳夹参考电极连接,通过管脚S1连接第二跟随器228的运算放大器U06A的反相输入端,通过管脚S2接地;Further, the second two-channel analog switch 226 in this embodiment adopts a chip U04A with a model number of ADG619, which is connected to the reference electrode of the ear clip through a signal line, and is connected to the reverse of the operational amplifier U06A of the second follower 228 through the pin S1. Phase input terminal, grounded through pin S2;
且第一射随器227由运算放大器U05A和连接于该运算放大器U05A的反相输 入端与输出端之间的电阻R30组成,该电阻R30的电阻值为100Ω;该运算放大器U05A的正极连接+5V电源,负极连接-5V电源;第二射随器228由运算放大器U06A和连接于该运算放大器U06A的反相输入端与输出端之间的电阻R31组成,该电阻R31的电阻值为100Ω。And the first emitter follower 227 is composed of an operational amplifier U05A and a resistor R30 connected between the inverting input terminal and the output terminal of the operational amplifier U05A. The resistance value of the resistor R30 is 100Ω; the positive electrode of the operational amplifier U05A is connected to + The 5V power supply, the negative pole is connected to the -5V power supply; the second emitter follower 228 is composed of an operational amplifier U06A and a resistor R31 connected between the inverting input terminal and the output terminal of the operational amplifier U06A. The resistance value of the resistor R31 is 100Ω.
在一具体实施例中,信号测量传感器21与传感器状态监测电路的运行过程为:信号测量传感器21的干电极阵列测量监测使用者不同睡眠姿势下的脑电信号;信号测量传感器21中的干电极阵列与阻抗转换模块223相连,其中信号测量传感器21中的每一个干电极与阻抗转换模块223中每个运算放大器U01A的反相输入端相连,实现阻抗转换;阻抗转换模块223中每运算放大器U01A将转换后的信号输出至多通道模拟开关224,多通道模拟开关224的芯片U01A的管脚NA1~NA8接收微控制器221输出的控制信号,实现针对阻抗转换模块223中每个运算放大器U01A输出信号的选择,然后通过多通道模拟开关224的管脚XI0输出至第一两通道模拟开关225的管脚S1;第一两通道模拟开关225的芯片U03A通过管脚NB接收微控制器221的控制信号,实现第一两通道模拟开关225的芯片U03A的管脚S1与第一两通道模拟开关225的芯片U03A的管脚S2或管脚IN相连接,其中与第一两通道模拟开关225的管脚S2连接表示该通道信号可用,经过第一射随器227后输出至图5中模拟信号放大及滤波电路23的模拟信号放大电路的运算放大器U1的信号输入端,经过电阻R229后连接至2.5V电压源,进行干电极与大脑头皮接触状态的监测;耳夹参考电极放置在耳垂位置,经过第二两通道模拟开关226后,在微控制器221的控制下通过管脚PA11输出控制信号,然后通过226的2脚输出至第二射随器208的负相输入端,然后通过208的Vref端输出,与信号测量传感器21的干电极阵列中的电极形成差分信号,输出至模拟信号放大及滤波电路;第二两通道模拟开关226在微控制器221的控制下实现芯片U04A的管脚S1与管脚D相连接时,将实现干电极与大脑头皮接触状态的监测;当微控制器221监测到与头皮接触阻抗最小的两个干电极后,将控制多通道模拟开关224选择这两个干电极与多通道模拟开关224中芯片U1A和芯片U2A的管脚XI0相连接,同时控制第一两通道模拟开关225的芯片U03A的管脚S1和管脚S2连接,以及控制第二两通道模拟开关226的输出端管脚与反相输入端管脚连接,形成信号采集电路;In a specific embodiment, the operation process of the signal measurement sensor 21 and the sensor state monitoring circuit is: the dry electrode array of the signal measurement sensor 21 measures and monitors the EEG signals of the user under different sleeping positions; the dry electrode in the signal measurement sensor 21 The array is connected to the impedance conversion module 223, wherein each dry electrode in the signal measurement sensor 21 is connected to the inverting input terminal of each operational amplifier U01A in the impedance conversion module 223 to realize impedance conversion; each operational amplifier U01A in the impedance conversion module 223 The converted signal is output to the multi-channel analog switch 224. The pins NA1~NA8 of the chip U01A of the multi-channel analog switch 224 receive the control signal output by the microcontroller 221 to realize the output signal for each operational amplifier U01A in the impedance conversion module 223 And then output to the pin S1 of the first two-channel analog switch 225 through the pin XI0 of the multi-channel analog switch 224; the chip U03A of the first two-channel analog switch 225 receives the control signal of the microcontroller 221 through the pin NB , Realize that the pin S1 of the chip U03A of the first two-channel analog switch 225 is connected to the pin S2 or the pin IN of the chip U03A of the first two-channel analog switch 225, which is connected to the pin of the first two-channel analog switch 225 S2 connection means that the channel signal is available. After passing through the first transmitter 227, it is output to the signal input terminal of the operational amplifier U1 of the analog signal amplifying circuit of the analog signal amplifying and filtering circuit 23 in Figure 5, and connected to 2.5V after passing through the resistor R229. The voltage source is used to monitor the contact state of the dry electrode and the brain scalp; the ear clip reference electrode is placed at the earlobe position, and after passing through the second two-channel analog switch 226, the control signal is output through the pin PA11 under the control of the microcontroller 221, and then Output through pin 2 of 226 to the negative input terminal of the second emitter follower 208, and then output through the Vref terminal of 208 to form a differential signal with the electrode in the dry electrode array of the signal measurement sensor 21, and output to analog signal amplification and filtering Circuit; the second two-channel analog switch 226 under the control of the microcontroller 221 realizes that when the pin S1 of the chip U04A is connected to the pin D, it will realize the monitoring of the contact state of the dry electrode and the brain scalp; when the microcontroller 221 monitors After reaching the two dry electrodes with the least contact impedance with the scalp, the multi-channel analog switch 224 will be controlled to select these two dry electrodes to connect to the pins XI0 of the chip U1A and the chip U2A in the multi-channel analog switch 224, and control the first two at the same time. The pin S1 of the chip U03A of the channel analog switch 225 is connected with the pin S2, and the output pin of the second two-channel analog switch 226 is controlled to be connected with the inverting input pin to form a signal acquisition circuit;
本实施例中的模拟信号放大及滤波电路的电路图可参考图5,连接第一模数转换器且包括模拟信号放大电路和二阶低通滤波电路;模拟信号放大电路由运算放大器U1~U3和电阻R0连接组成,该运算放大器U1和U2的型号为AD8639,该运算放大器U3的型号为AD8424;该运算放大器U1的同相输入端为信号输入端,反向输入端连接至输出端;该运算放大器U2的同相输入端为参考信号输入端,反向输入端连接至输出端;该运算放大器U3的反相输入端连接该运算放大器U1的输出端,该运算放大器U3的同相输入端连接该运算放大器U2的输出端;该电阻R0连接于该运算放大器U3的同相输入端和反相输入端之间。如图5所示,该二阶低通滤波电路由电阻R1~R4、电容C1~C2、运算放大器U4连接组成;该运算放大器U4的型号为AD8639;其中,该电阻R1一端为二阶低通滤波电路的输入管脚VIN且与图6中的运算放大器U3的输出端管脚Vout连接,该电阻R1另一端连接电阻R2并通过电阻R2连接于运算放大器U4的反相输入端;该电阻R4一端接地,另一端连接运算放大器U4的同相输入端;该电容C1一端接地,另一端连接电阻R3并通过电阻R3连接于运算放大器U4的输出端;该电阻R4一端接地,另一端连接运算放大器U4的同相输入端。For the circuit diagram of the analog signal amplifying and filtering circuit in this embodiment, refer to Figure 5, which is connected to the first analog-to-digital converter and includes an analog signal amplifying circuit and a second-order low-pass filter circuit; the analog signal amplifying circuit consists of operational amplifiers U1 to U3 and Resistor R0 is connected, the model of the operational amplifier U1 and U2 is AD8639, the model of the operational amplifier U3 is AD8424; the non-inverting input terminal of the operational amplifier U1 is the signal input terminal, and the reverse input terminal is connected to the output terminal; the operational amplifier The non-inverting input terminal of U2 is the reference signal input terminal, and the inverting input terminal is connected to the output terminal; the inverting input terminal of the operational amplifier U3 is connected to the output terminal of the operational amplifier U1, and the non-inverting input terminal of the operational amplifier U3 is connected to the operational amplifier The output terminal of U2; the resistor R0 is connected between the non-inverting input terminal and the inverting input terminal of the operational amplifier U3. As shown in Figure 5, the second-order low-pass filter circuit is composed of resistors R1 to R4, capacitors C1 to C2, and an operational amplifier U4. The model of the operational amplifier U4 is AD8639; among them, one end of the resistor R1 is a second-order low-pass The input pin VIN of the filter circuit is connected to the output pin Vout of the operational amplifier U3 in FIG. 6, and the other end of the resistor R1 is connected to the resistor R2 and connected to the inverting input terminal of the operational amplifier U4 through the resistor R2; the resistor R4 One end is grounded, and the other end is connected to the non-inverting input end of the operational amplifier U4; one end of the capacitor C1 is grounded, the other end is connected to the resistor R3 and connected to the output end of the operational amplifier U4 through the resistor R3; one end of the resistor R4 is grounded, and the other end is connected to the operational amplifier U4 The non-inverting input terminal.
本实施例中的第一模数转换器的电路图可参考图6,具体地,第一模数转换 器电连接分析监测单元内23,且由运算放大器U5、电阻R21~R24、模数转换器U6连接组成;该运算放大器U5的型号为THS4521;该模数转换器U6的型号为ADS1278;该电阻R21一端为第一模数转换器输入管脚Vin且与图7中的运算放大器U4的输出端管脚VOUT连接,该电阻R21另一端连接电阻R22并通过电阻R22连接运算放大器U5的负极端;该电阻R24一端接地,另一端连接运算放大器U5的反相输入端;该电阻R23一端连接运算放大器U5的反相输入端,另一端连接运算放大器U5的正极;该运算放大器U5的同相输入端连接于电阻R21与电阻R22之间;该模数转换器U6通过管脚AIN_N连接运算放大器U5的负极,通过管脚VCOM连接运算放大器U5的输出端,通过管脚AIN_P连接运算放大器U5的正极;该模数转换器U6还具有信号控制线和数据输出线,该模数转换器U6的信号控制线与图7中的分析监测单元内23的芯片U5A的管脚XA0相连,该模数转换器U6的数据输出线与图7中的分析监测单元内23的芯片U5A的管脚XA1相连;通过模数转换器U6将滤波放大后的模拟脑电信号转换为数字信号,由于模数转换器U6为全差分输入方式,因此需要将单端模拟信号转换为差分信号,采用单端转差分芯片THS4521即运算放大器U5,实现单端输入差分输出;For the circuit diagram of the first analog-to-digital converter in this embodiment, refer to FIG. 6. Specifically, the first analog-to-digital converter is electrically connected to the analysis and monitoring unit 23, and is composed of an operational amplifier U5, resistors R21 to R24, and an analog-to-digital converter. U6 is connected; the model of the operational amplifier U5 is THS4521; the model of the analog-to-digital converter U6 is ADS1278; one end of the resistor R21 is the first analog-to-digital converter input pin Vin and is connected to the output of the operational amplifier U4 in Figure 7 The other end of the resistor R21 is connected to the resistor R22 and the negative terminal of the operational amplifier U5 through the resistor R22; one end of the resistor R24 is grounded, and the other end is connected to the inverting input terminal of the operational amplifier U5; one end of the resistor R23 is connected to the operational amplifier U5 The inverting input terminal of the amplifier U5, the other end is connected to the positive electrode of the operational amplifier U5; the non-inverting input terminal of the operational amplifier U5 is connected between the resistor R21 and the resistor R22; the analog-to-digital converter U6 is connected to the operational amplifier U5 through the pin AIN_N The negative pole is connected to the output terminal of the operational amplifier U5 through the pin VCOM, and the positive pole of the operational amplifier U5 through the pin AIN_P; the analog-to-digital converter U6 also has a signal control line and a data output line, and the signal control of the analog-to-digital converter U6 The line is connected to the pin XA0 of the chip U5A in the analysis and monitoring unit 23 in Fig. 7, and the data output line of the analog-to-digital converter U6 is connected to the pin XA1 of the chip U5A in the analysis and monitoring unit 23 in Fig. 7; The analog-to-digital converter U6 converts the filtered and amplified analog EEG signal into a digital signal. Because the analog-to-digital converter U6 is a fully differential input mode, it is necessary to convert a single-ended analog signal to a differential signal, using a single-ended to differential chip THS4521 That is, operational amplifier U5, which realizes single-ended input and differential output;
分析监测单元23与信号预处理单元22相连,用于对数字生理信号进行特征提取、特征识别、特征分类,对睡眠状态进行监测;The analysis and monitoring unit 23 is connected to the signal preprocessing unit 22, and is used to perform feature extraction, feature recognition, and feature classification on the digital physiological signal, and monitor the sleep state;
本实施例中的分析监测单元23为多核数字处理器(DSP+ARM+FPGA),分析监测单元23由芯片U5A、芯片J5、芯片S001、电阻RJ4~RJ13、电阻RJ53~RJ57、电容CC3、电容C15~C19、电容C52~C53、晶振X2组成,其电路图可参考图7,优选地:The analysis and monitoring unit 23 in this embodiment is a multi-core digital processor (DSP+ARM+FPGA). The analysis and monitoring unit 23 is composed of chip U5A, chip J5, chip S001, resistors RJ4 to RJ13, resistors RJ53 to RJ57, capacitors CC3, and capacitors. C15 ~ C19, capacitors C52 ~ C53, crystal oscillator X2, the circuit diagram can refer to Figure 7, preferably:
在一具体实施例中,电阻RJ4的电阻值为4.7KΩ,电阻RJ5、电阻RJ11和电阻RJ13的电阻值均为2KΩ,电阻RJ6的电阻值为1KΩ,电阻RJ7和电阻RJ8的电阻值均为3KΩ,电阻RJ9的电阻值为22KΩ,电阻RJ10和电阻RJ12的电阻值均为4KΩ;该电阻RJ53~RJ57的电阻值均为330Ω;该电容CC3、电容C15~C17、该电容C52~C53的电容值均为104F,该电容C18和电容C19的电容值均为24PF;芯片U5A的型号为TMS320F2812PGF;In a specific embodiment, the resistance value of the resistor RJ4 is 4.7KΩ, the resistance value of the resistor RJ5, the resistor RJ11, and the resistor RJ13 are all 2KΩ, the resistance value of the resistor RJ6 is 1KΩ, and the resistance value of the resistor RJ7 and the resistor RJ8 are both 3KΩ. , The resistance value of the resistor RJ9 is 22KΩ, the resistance values of the resistors RJ10 and RJ12 are both 4KΩ; the resistance values of the resistors RJ53~RJ57 are all 330Ω; the capacitance values of the capacitor CC3, the capacitors C15~C17, and the capacitors C52~C53 Both are 104F, and the capacitance values of the capacitors C18 and C19 are both 24PF; the model of the chip U5A is TMS320F2812PGF;
连接方式为:电阻RJ9一端接地GND,另一端连接芯片U5A的管脚ADCRESEXT;电容C52一端接地GND,另一端连接芯片U5A的管脚ADCREFM;电容C53一端接地GND,另一端连接芯片U5A的管脚ADCREFP;电阻RJ53一端连接电源VDD33,另一端连接芯片U5A的管脚XHOLD;电阻RJ54一端连接电源VDD33,另一端连接芯片U5A的管脚XHOLDA;电阻R57一端连接电源VDD33,另一端连接芯片U5A的管脚XREADY;晶振X2的频率为30MHz,其一端连接芯片U5A的管脚X2,另一端连接芯片U5A的管脚X2;电容C18一端接地,另一端连接芯片U5A的管脚X2;电容C19一端接地,另一端连接芯片U5A的管脚X2;The connection method is: one end of the resistor RJ9 is grounded to GND, the other end is connected to the pin ADCRESEXT of the chip U5A; one end of the capacitor C52 is grounded to GND, and the other end is connected to the pin ADCREFM of the chip U5A; one end of the capacitor C53 is grounded to GND, and the other end is connected to the pin of the chip U5A ADCREFP; one end of the resistor RJ53 is connected to the power supply VDD33, the other end is connected to the pin XHOLD of the chip U5A; one end of the resistor RJ54 is connected to the power supply VDD33, and the other end is connected to the pin XHOLDA of the chip U5A; one end of the resistor R57 is connected to the power supply VDD33, and the other end is connected to the tube of the chip U5A Pin XREADY; the frequency of the crystal oscillator X2 is 30MHz, one end is connected to the pin X2 of the chip U5A, the other end is connected to the pin X2 of the chip U5A; one end of the capacitor C18 is grounded, and the other end is connected to the pin X2 of the chip U5A; one end of the capacitor C19 is grounded, The other end is connected to pin X2 of chip U5A;
进一步地,芯片J5的型号为JTAG且具有14个管脚,其通过8号管脚接地,通过3号管脚连接图7中芯片U5A的管脚TDI,通过7号管脚连接图7中芯片U5A的管脚TDO;电容C15一端连接电阻RJ4并通过电阻RJ4连接至芯片J5的1号管脚,电容C15另一端连接电阻RJ6并通过电阻RJ6连接至芯片J5的9号和11号管脚;电容C16一端接地,另一端连接芯片J5的5号管脚;电阻RJ5一端接地,另一端连接芯片J5的2号管脚;电阻RJ7一端连接电源VDD33,另一端连接芯片J5的13号管脚;电阻RJ8一端连接电源VDD33,另一端连接芯片J5的14号管脚;电容C17一端接地,另一端连接于电源VDD33;Further, the model of the chip J5 is JTAG and has 14 pins, which are grounded through pin 8 and connected to the pin TDI of chip U5A in FIG. 7 through pin 3, and connected to the chip in FIG. 7 through pin 7 U5A pin TDO; one end of capacitor C15 is connected to resistor RJ4 and connected to pin 1 of chip J5 through resistor RJ4, and the other end of capacitor C15 is connected to resistor RJ6 and connected to pins 9 and 11 of chip J5 through resistor RJ6; One end of the capacitor C16 is grounded, and the other end is connected to the No. 5 pin of the chip J5; one end of the resistor RJ5 is grounded, and the other end is connected to the No. 2 pin of the chip J5; one end of the resistor RJ7 is connected to the power supply VDD33, and the other end is connected to the No. 13 pin of the chip J5; One end of the resistor RJ8 is connected to the power supply VDD33, and the other end is connected to the 14th pin of the chip J5; one end of the capacitor C17 is grounded, and the other end is connected to the power supply VDD33;
在一实施例中,芯片S001的型号为SW DIP-2;该芯片S001通过1号管脚连接 电阻R13并通过电阻R13接地;芯片S001通过2号管脚连接电阻R11并通过电阻R11接地;芯片S001通过3号管脚连接电阻R10并通过电阻R10连接电源VDD33;芯片S001通过4号管脚连接电阻R12并通过电阻R12连接电源VDD33;电容CC3一端接地,另一端连接电源VDD33。In one embodiment, the model of the chip S001 is SW DIP-2; the chip S001 is connected to the resistor R13 through pin 1 and grounded through the resistor R13; the chip S001 is connected to the resistor R11 through pin 2 and grounded through the resistor R11; S001 is connected to resistor R10 through pin 3 and connected to power source VDD33 through resistor R10; chip S001 is connected to resistor R12 through pin 4 and power source VDD33 through resistor R12; one end of capacitor CC3 is grounded, and the other end is connected to power source VDD33.
睡眠调控模块3与睡眠监测模块2信号相连,用于根据监测结果,输出用于对睡眠环境进行调控的调控参数。The sleep control module 3 is signal-connected to the sleep monitoring module 2 and is used for outputting control parameters for regulating the sleep environment according to the monitoring result.
本实施例中的睡眠调控模块3包括微电流刺激单元31、光线调节单元32、体感震动单元33、温度控制单元34;睡眠调控模块3的电路图参考图8,其中,The sleep control module 3 in this embodiment includes a micro-current stimulation unit 31, a light adjustment unit 32, a somatosensory vibration unit 33, and a temperature control unit 34; refer to FIG. 8 for the circuit diagram of the sleep control module 3, where,
微电流刺激单元31用于根据监测结果输出电流调控参数,实现对人脑不同区域的微电流刺激,调整睡眠状态;The micro-current stimulation unit 31 is used to output current control parameters according to the monitoring result, realize the micro-current stimulation of different regions of the human brain, and adjust the sleep state;
微电流刺激单元31与分析监测单元23电连接,包括信号生成器311、恒流源电路312、过流保护电路313和紧急机械控制开关314;信号生成器311的信号输入端与分析监测单元内23电连接,信号输出端连接恒流源电路312;恒流源电路312分别与过流保护电路313和紧急机械控制开关314电连接;过流保护电路313的输出端IO与人体相连接,实现对人体的微电流刺激,且当经过电流超过预设阈值时,自动断电;The micro-current stimulation unit 31 is electrically connected to the analysis and monitoring unit 23, and includes a signal generator 311, a constant current source circuit 312, an overcurrent protection circuit 313, and an emergency mechanical control switch 314; the signal input terminal of the signal generator 311 is connected to the analysis and monitoring unit 23 is electrically connected, the signal output terminal is connected to the constant current source circuit 312; the constant current source circuit 312 is electrically connected to the overcurrent protection circuit 313 and the emergency mechanical control switch 314; the output terminal IO of the overcurrent protection circuit 313 is connected to the human body to realize Micro-current stimulation to the human body, and when the passing current exceeds the preset threshold, the power is automatically cut off;
进一步地,信号生成器311、恒流源电路312的电路图可参考图9,信号生成器311由芯片DAC1、电容C2和电容C3组成;恒流源电路312由电容C5、电容C6、电容Cp6、电容C8、电阻R6、电阻R7、电阻RdaD1、电阻R15、稳压二极管D0组成;稳压二极管D0的型号为SMBJ2。电容C2、电容C3、电容C6、电容C8的电容值均为104F;电容Cp6的电容值为10uF;电阻R6的电阻值为15Ω,电阻R7和电阻RdaD1均为零阻值;电阻R15的电阻值为15KΩ;Further, the circuit diagram of the signal generator 311 and the constant current source circuit 312 can refer to FIG. 9. The signal generator 311 is composed of a chip DAC1, a capacitor C2, and a capacitor C3; the constant current source circuit 312 is composed of a capacitor C5, a capacitor C6, a capacitor Cp6, The capacitor C8, the resistor R6, the resistor R7, the resistor RdaD1, the resistor R15, and the Zener diode D0 are composed; the model of the Zener diode D0 is SMBJ2. Capacitor C2, Capacitor C3, Capacitor C6, Capacitor C8 have a capacitance value of 104F; Capacitance Cp6 has a capacitance value of 10uF; Resistance R6 has a resistance value of 15Ω, R7 and RdaD1 have zero resistance; resistance R15 has a resistance value 15KΩ;
芯片DAC1的型号为DAC7760,其通过管脚-VSENSE和管脚DVDD-EN接地AGND,通过管脚DVDD连接3.3V电源,通过管脚ALARM连接图3中芯片U3A的管脚PB0,通过管脚LATCH连接图7中分析监测单元23的芯片U5A的管脚XA2,通过管脚SCLK连接图7中分析监测单元内23的芯片U5A的管脚XA3,通过管脚DIN连接图3中芯片U3A的管脚PA7,通过管脚SD0连接图3中芯片U3A的管脚PA6;电容C2和C3均一端接地,另一端均连接芯片DAC1的管脚DVDD;电阻R6一端连接芯片DAC1的管脚IOUT,另一端连接电阻R7并通过电阻R7连接图10中的芯片U7的管脚IN+;稳压二极管D0的阳极端接地,阴极端连接于电阻R6与电阻R7之间的连接点;电容C5一端连接芯片DAC1的管脚HART-IN,另一端接地;电容C8一端接地,另一端分别连接芯片DAC1的管脚REFIN和管脚REFOUT;电阻R15一端接地,另一端连接芯片DAC1的管脚ISET-R;电阻RdaD1一端连接15V电源,另一端连接芯片DAC1的管脚DAVDD;电容C6和电容Cp6均一端接地,另一端连接芯片DAC1的管脚DAVDD。The model of the chip DAC1 is DAC7760, which is grounded to AGND through the pin -VSENSE and the pin DVDD-EN, is connected to the 3.3V power supply through the pin DVDD, is connected to the pin PB0 of the chip U3A in Figure 3 through the pin ALARM, and through the pin LATCH Connect the pin XA2 of the chip U5A of the analysis and monitoring unit 23 in Fig. 7, connect the pin XA3 of the chip U5A of the analysis and monitoring unit 23 in Fig. 7 through the pin SCLK, and connect the pin of the chip U3A in Fig. 3 through the pin DIN PA7 is connected to pin PA6 of chip U3A in Figure 3 through pin SD0; one end of capacitors C2 and C3 are grounded, and the other end is connected to pin DVDD of chip DAC1; one end of resistor R6 is connected to pin IOUT of chip DAC1, and the other end is connected The resistor R7 is connected to the pin IN+ of the chip U7 in Figure 10 through the resistor R7; the anode terminal of the Zener diode D0 is grounded, and the cathode terminal is connected to the connection point between the resistor R6 and the resistor R7; one end of the capacitor C5 is connected to the tube of the chip DAC1 Pin HART-IN, the other end is grounded; one end of capacitor C8 is grounded, and the other end is connected to pin REFIN and pin REFOUT of chip DAC1 respectively; one end of resistor R15 is grounded, and the other end is connected to pin ISET-R of chip DAC1; one end of resistor RdaD1 is connected 15V power supply, the other end is connected to the pin DAVDD of the chip DAC1; the capacitor C6 and the capacitor Cp6 are both grounded at one end, and the other end is connected to the pin DAVDD of the chip DAC1.
再进一步地,过流保护电路313的电路图可参考图10,由芯片U7、电阻R101、电阻R102、电阻Rsense1、电阻Rlimit1、电容C1组成;电阻R101的阻值为10KΩ,该电阻R102为零阻值,该电阻Rsense1的阻值为10~100Ω,该电阻Rlimit1的电阻值为20K~23.5KΩ;该电容C1的电容值为104F;Furthermore, the circuit diagram of the over-current protection circuit 313 can be referred to as FIG. 10, which is composed of chip U7, resistor R101, resistor R102, resistor Rsense1, resistor Rlimit1, and capacitor C1; the resistance value of resistor R101 is 10KΩ, and the resistance R102 is zero resistance. The resistance value of the resistor Rsense1 is 10-100Ω, the resistance value of the resistor Rlimit1 is 20K-23.5KΩ; the capacitance value of the capacitor C1 is 104F;
本实施例中,芯片U7的型号为INA301A1,其通过管脚VS连接3.3V电源,通过管脚OUT连接图3中芯片U3A的管脚PB1,通过管脚ALERT连接图3中芯片U3A的管脚PB10,通过管脚RESET连接图3中芯片U3A的管脚PB2,通过管脚LIMIT连接图3中芯片U3A的管脚PA5,通过管脚GND接地AGND;该电阻Rsense1连接于芯片U7的管脚IN+和管脚IN-之间;该电容C1一端连接芯片U7的管脚VS,另一端接地;该电阻R101一端连接芯片U7的管脚VS,另一端连接芯片U7的管 脚ALERT;该电阻Rlimit1一端连接芯片U7的管脚GND,另一端连接电阻R102并通过电阻R102连接芯片U7的管脚LIMIT。In this embodiment, the model of chip U7 is INA301A1, which is connected to a 3.3V power supply through pin VS, connected to pin PB1 of chip U3A in Figure 3 through pin OUT, and connected to pin U3A of chip U3A in Figure 3 through pin ALERT PB10, connect pin PB2 of chip U3A in Figure 3 through pin RESET, connect pin PA5 of chip U3A in Figure 3 through pin LIMIT, and ground AGND through pin GND; this resistor Rsense1 is connected to pin IN+ of chip U7 Between the capacitor C1 and the pin IN-; one end of the capacitor C1 is connected to the pin VS of the chip U7, and the other end is grounded; one end of the resistor R101 is connected to the pin VS of the chip U7, and the other end is connected to the pin ALERT of the chip U7; one end of the resistor Rlimit1 Connect the pin GND of the chip U7, the other end is connected to the resistor R102 and the pin LIMIT of the chip U7 is connected through the resistor R102.
进一步地,紧急机械控制开关314的电路图可参考图11,由三极管Q1、电阻R100和开关S1组成;电阻R100的电阻值为1KΩ。其中,三极管Q1采用PNP三极管,其集电极接地,基极连接图7中分析监测单元内23的芯片U5A的管脚XA4,发射极连接电阻R100一端;电阻R100另一端连接开关S1并通过开关S1接地。Further, the circuit diagram of the emergency mechanical control switch 314 can refer to FIG. 11, which is composed of a transistor Q1, a resistor R100, and a switch S1; the resistance value of the resistor R100 is 1KΩ. Among them, the transistor Q1 adopts a PNP transistor, its collector is grounded, the base is connected to the pin XA4 of the chip U5A in the analysis and monitoring unit 23 in Figure 7, the emitter is connected to one end of the resistor R100; the other end of the resistor R100 is connected to the switch S1 and passes through the switch S1 Grounded.
光线调节单元32用于根据监测结果输出光线调控参数,发出不同的光线帮助人调节昼夜生活规律和其它生物效应;The light adjustment unit 32 is used to output light adjustment parameters according to the monitoring results, and emit different lights to help people adjust the day and night life rules and other biological effects;
本实施例中,光线调节单元32与分析监测单元23电连接,其电路图参考图12,光线调节单元32具有6个管脚,1号管脚A1与图7中分析监测单元内23的芯片U5A的管脚GPIOB0-PWM7相连,2号管脚A2与图7中分析监测单元23的芯片U5A的管脚GPIOB1-PWM8相连,3号管脚IO1与图7中的分析监测单元内23的芯片U5A的管脚GPIOB2-PWM9相连,4号管脚IO2与图7中的分析监测单元内23的芯片U5A的管脚GPIOB3-PWM10相连,5号管脚IO3与图7中的分析监测单元内23的芯片U5A的管脚GPIOB4-PWM11相连,6号管脚IO4与图7中的分析监测单元内23的芯片U5A的管脚GPIOB5-PWM12相连。In this embodiment, the light adjustment unit 32 is electrically connected to the analysis and monitoring unit 23. Refer to FIG. 12 for the circuit diagram. The light adjustment unit 32 has 6 pins. The No. 1 pin A1 is connected to the chip U5A in the analysis and monitoring unit 23 in FIG. The pins GPIOB0-PWM7 are connected, the second pin A2 is connected to the pins GPIOB1-PWM8 of the chip U5A of the analysis and monitoring unit 23 in Fig. 7, and the third pin IO1 is connected to the chip U5A of the 23 in the analysis and monitoring unit in Fig. 7 The pins GPIOB2-PWM9 are connected, the 4th pin IO2 is connected to the pins GPIOB3-PWM10 of the chip U5A in the analysis and monitoring unit 23 in Fig. 7, and the 5th pin IO3 is connected to the 23’s in the analysis and monitoring unit in Fig. 7 The pins GPIOB4-PWM11 of the chip U5A are connected, and the 6th pin IO4 is connected to the pins GPIOB5-PWM12 of the chip U5A 23 in the analysis monitoring unit in FIG. 7.
体感震动单元33用于根据监测结果输出震动调控参数,控制电机发出不同强度或频率的震动,进行体感调控;The somatosensory vibration unit 33 is used to output vibration control parameters according to the monitoring results, control the motor to emit vibrations of different intensities or frequencies, and perform somatosensory control;
本实施例中,体感震动单元33与分析监测单元23电连接,其电路图可参考图13,由四个震动单元组成;第一震动单元UC1的1号管脚接地,2号管脚连接电阻R01并通过电阻R01连接电源VCC;第二震动单元UC2的1号管脚接地,2号管脚连接电阻R02并通过电阻R02连接电源VCC;第三震动单元UC3的1号管脚接地,2号管脚连接电阻R03并通过电阻R03连接电源VCC;第四震动单元UC4的1号管脚接地,2号管脚连接电阻R04并通过电阻R04连接电源VCC;电阻R01~R04的电阻均为1KΩ。In this embodiment, the somatosensory vibration unit 33 is electrically connected to the analysis and monitoring unit 23. Refer to Figure 13 for the circuit diagram, which is composed of four vibration units; the first vibration unit UC1 has pin 1 grounded, and pin 2 is connected to a resistor R01 And connect the power supply VCC through the resistor R01; the No. 1 pin of the second vibration unit UC2 is grounded, the No. 2 pin is connected to the resistor R02 and the power supply VCC through the resistor R02; The No. 1 pin of the third vibration unit UC3 is grounded, and the No. 2 tube The pin is connected to the resistor R03 and the power supply VCC through the resistor R03; the pin 1 of the fourth vibration unit UC4 is grounded, the pin 2 is connected to the resistor R04 and the power source VCC is connected through the resistor R04; the resistances of the resistors R01 to R04 are all 1KΩ.
温度控制单元34用于根据监测结果输出温度调控参数调整睡眠环境温度;The temperature control unit 34 is configured to output temperature control parameters according to the monitoring result to adjust the sleep environment temperature;
本实施例中,温度控制单元34与分析监测单元23电连接,电路图可参考图14,温度控制单元34由温度传感器T1、电加热器J1和J2组成;该温度传感器T1的1号管脚为测量点(即与人体身体接触点),2号管脚为数据线且与图7中分析监测单元23的芯片U5A的管脚XA0连接;该电加热器J1一端接地GND,另一端为控制电加热器J1工作的信号线且与中分析监测单元23的芯片U5A的管脚GPIOB6-T3PWM_T3CMP连接;该电加热器J2一端接地GND,另一端为控制电加热器J2工作的信号线且与分析监测单元23的芯片U5A的管脚GPIOB7-T4PWM_T4CMP连接。In this embodiment, the temperature control unit 34 is electrically connected to the analysis and monitoring unit 23. For the circuit diagram, refer to FIG. 14. The temperature control unit 34 is composed of a temperature sensor T1, electric heaters J1 and J2; the temperature sensor T1's No. 1 pin is Measuring point (that is, the contact point with the human body), the No. 2 pin is a data line and is connected to the pin XA0 of the chip U5A of the analysis and monitoring unit 23 in Fig. 7; one end of the electric heater J1 is grounded to GND, and the other end is a control circuit The signal line of heater J1 is connected to the pins GPIOB6-T3PWM_T3CMP of chip U5A of the analysis and monitoring unit 23; one end of the electric heater J2 is grounded, and the other end is the signal line that controls the operation of the electric heater J2 and is connected to the analysis and monitoring The pins GPIOB7-T4PWM_T4CMP of the chip U5A of the unit 23 are connected.
本实施例的一种基于人体多模信号的睡眠监测调控装置在使用时:When the device for monitoring and regulating sleep based on human multi-mode signals of this embodiment is in use:
通过信号测量传感器21获得人体生理电信号,然后经过信号预处理单元22的传感器状态监测电路后,将与人体接触状态良好的传感器获得的信号传输至模拟信号放大及滤波电路,实现对模拟信号的放大和滤波,接着在分析监测单元23的控制下,控制第一模数转换器将模拟信号转换为数字信号(分析监测单元23中FPGA核实现),分析监测单元23读取到第一模数转换器输出的数字信号后,对信号进行处理,包括信号预处理、特征提取、特征识别、特征分类等操作,实现对睡眠状态监测(分析监测单元23中DSP核实现),同时分析监测单元23实时显示多模态生理信号和输出的调控参数(分析监测单元23中ARM核实现); 根据睡眠监测模块2的监测结果,输出不同参数,控制睡眠调控模块3的功能模块,输出不同的调控数据;睡眠调控模块3中,通过微电流刺激单元31输出不同的电流参数,实现对人脑不同区域的微电流刺激,调整睡眠状态;通过光线调节单元32发出不同的光线帮助人调节昼夜生活规律和其它生物效应;通过体感震动单元33控制电机,发出不同强度或频率的震动,进行体感调控;通过温度控制单元34调整床垫温度,辅助睡眠。The human body physiological electrical signal is obtained by the signal measurement sensor 21, and then after the sensor state monitoring circuit of the signal preprocessing unit 22, the signal obtained by the sensor in good contact with the human body is transmitted to the analog signal amplifying and filtering circuit to realize the analog signal Amplify and filter, and then, under the control of the analysis and monitoring unit 23, control the first analog-to-digital converter to convert the analog signal into a digital signal (implemented by FPGA core in the analysis and monitoring unit 23), and the analysis and monitoring unit 23 reads the first analog-to-digital After the digital signal output by the converter, the signal is processed, including signal preprocessing, feature extraction, feature recognition, feature classification and other operations to realize sleep state monitoring (implemented by the DSP core in the analysis and monitoring unit 23), and at the same time, the analysis and monitoring unit 23 Real-time display of multi-modal physiological signals and output control parameters (implemented by the ARM core in the analysis and monitoring unit 23); According to the monitoring results of the sleep monitoring module 2, output different parameters, control the functional modules of the sleep control module 3, and output different control data In the sleep control module 3, the micro-current stimulation unit 31 outputs different current parameters to achieve micro-current stimulation of different areas of the human brain and adjust the sleep state; the light adjustment unit 32 emits different light to help people adjust the day and night life rules and Other biological effects; the motor is controlled by the somatosensory vibration unit 33 to emit vibrations of different intensities or frequencies for somatosensory regulation; the temperature control unit 34 is used to adjust the temperature of the mattress to assist sleep.
进一步地,该微电流刺激单元31用于对睡眠状态的调控:信号生成器311,如AD9831,在图7中分析监测单元23的控制下,据不同睡眠状态,控制信号生成器311输出不同幅度、频率的刺激信号;然后该刺激信号输出至恒流源电路312处理,稳定输出需要的电流信号;同时为了防止突发情况,电流过大,对人体产生伤害,恒流源电路312输出的电流将经过过流保护电路313,当电流超过设定阈值时,电路自动断电,有效保护人体;同时为了提高安全级数,采用双机制保护,即采用紧急机械控制开关314,当使用者感觉不适或过流保护电路313无法发挥作用时,采用紧急机械控制开关314可以实现电路紧急断开。Further, the micro-current stimulation unit 31 is used to regulate the sleep state: the signal generator 311, such as AD9831, is controlled by the analysis and monitoring unit 23 in FIG. 7 to control the signal generator 311 to output different amplitudes according to different sleep states. The stimulus signal of frequency; then the stimulus signal is output to the constant current source circuit 312 for processing, and the required current signal is stably output; at the same time, in order to prevent sudden situations, the current is too large and cause harm to the human body, the current output by the constant current source circuit 312 It will pass through the over-current protection circuit 313. When the current exceeds the set threshold, the circuit will automatically cut off power to effectively protect the human body. At the same time, in order to improve the safety level, dual-mechanism protection is adopted, that is, the emergency mechanical control switch 314 is adopted. When the user feels unwell Or when the overcurrent protection circuit 313 cannot function, the emergency mechanical control switch 314 can be used to realize the circuit emergency disconnection.
优选地,本实施例中还提供一种脑电采集电极(干电极)与大脑头皮接触状态的监测:电路图可参考图2中,微控制器221进行干电极与头皮接触状态监测时的判断方式为:利用第二模数转换器222获取205的3脚与207相连之间的电压值V1,207电阻阻值设为R,则干电极与头皮接触Rz为:Preferably, this embodiment also provides a monitoring of the contact state of the brain electricity collection electrode (dry electrode) with the brain scalp: the circuit diagram can refer to FIG. 2, the judgment method of the microcontroller 221 when the dry electrode and the scalp contact state are monitored To: Use the second analog-to-digital converter 222 to obtain the voltage value V1 between the 3 pins of the 205 and the 207 connection, and set the resistance value of the 207 to R, then the contact Rz between the dry electrode and the scalp is:
Figure PCTCN2020136635-appb-000001
Figure PCTCN2020136635-appb-000001
Figure PCTCN2020136635-appb-000002
Figure PCTCN2020136635-appb-000002
优选地,本实施例中R的取值为10K~50KΩ,根据以上公式获得Rz的值,当Rz值大于100KΩ时,认定为干电极与头皮无接触;当Rz值小于等于100KΩ时,认定为干电极与头皮无接触,同时选择阻抗值最小的两个电极,作为有效传感器采集脑电信号;Preferably, the value of R in this embodiment is 10K~50KΩ, and the value of Rz is obtained according to the above formula. When the value of Rz is greater than 100KΩ, it is considered that the dry electrode has no contact with the scalp; when the value of Rz is less than or equal to 100KΩ, it is considered to be The dry electrode has no contact with the scalp, and the two electrodes with the smallest impedance value are selected at the same time as effective sensors to collect EEG signals;
进一步地,分析监测单元内23还设置有自动分期模型,自动分期模型用于对睡眠状态分类,自动分期模型的获得即睡眠自动分期算法流程图可参考图15;Further, the analysis and monitoring unit 23 is also provided with an automatic staging model, the automatic staging model is used to classify the sleep state, the acquisition of the automatic staging model, that is, the flow chart of the automatic sleep staging algorithm can refer to FIG. 15;
具体地,针对睡眠状态的判别,采用自动分期方法,即通过IIR巴特沃斯带通滤波器(0.3Hz-35Hz)对脑电进行伪迹去除,之后按时间序列顺序不重叠的进行30秒信号分段以得到分期数据帧,最后对分段数据帧加Hamming窗,从而得到整个算法的输入空间;然后,针对每段数据帧,算法分别提取脑电的时域特征、频域特征、时频特征及非线性特征构成25维特征空间;接着将特征空间及专家分期标记组成训练集作为支持向量机模型的输入并训练分期模型;最终对分期模型的分类准确性和泛化性能进行测试并选择测试结果最优的模型作为自动分期模型。Specifically, for the determination of sleep status, an automatic staging method is adopted, that is, the EEG is removed by the IIR Butterworth bandpass filter (0.3Hz-35Hz), and then the signal is performed for 30 seconds without overlapping in the time series. Segment to obtain the staging data frame, and finally add a Hamming window to the segmented data frame to obtain the input space of the entire algorithm; then, for each data frame, the algorithm extracts the time domain features, frequency domain features, and time-frequency features of the EEG separately Features and nonlinear features constitute a 25-dimensional feature space; then the feature space and expert staging markers are used to form a training set as the input of the support vector machine model and the staging model is trained; finally, the classification accuracy and generalization performance of the staging model are tested and selected The model with the best test result is used as the automatic staging model.
本实施例中的装置,以脑电信号为主,作为睡眠监测的主要依据,在设计硬件电路时,以干电极组成阵列,作为传感器获得脑电信号,同时硬件电路能够自动监测使用者头皮与电极接触状态,选择接触最好的两通道信号进行采集,既能保证不对使用者造成额外影响,又能获得较高的脑电信号;The device in this embodiment uses EEG signals as the main basis for sleep monitoring. When designing the hardware circuit, dry electrodes are used to form an array to obtain EEG signals as sensors. At the same time, the hardware circuit can automatically monitor the user's scalp and For the electrode contact state, select the best two-channel signal for collection, which can not only ensure no additional impact on the user, but also obtain a higher EEG signal;
且本装置的硬件电路具有便携性,国内外医生认可的睡眠设备是多导睡眠监测系统(polysomnography,PSG),但该系统体积大,需要专门的电脑进行 数据分析采集,而且使用时需要专业人员帮助才能使用;本专利采用分析监测单元23(多核处理器),如AM5728,利用FPGA核实现对模数转换器的控制,将模拟信号转换为数字信号,然后利用DSP核实现对信号进行处理,包括信号预处理、特征提取、特征识别、特征分类等操作,实现对睡眠状态监测,同时DSP核根据睡眠状态监测结果,设置调控参数,并实时显示多模态生理信号和输出的调控参数,从而摆脱传统电脑的依赖,实现了系统的便携性;In addition, the hardware circuit of this device is portable. The sleep device recognized by doctors at home and abroad is polysomnography (PSG), but the system is large in size and requires a special computer for data analysis and collection, and requires professionals to use it. Help can be used; this patent uses the analysis and monitoring unit 23 (multi-core processor), such as AM5728, uses FPGA core to realize the control of the analog-to-digital converter, converts the analog signal into digital signal, and then uses the DSP core to realize the signal processing, Including signal preprocessing, feature extraction, feature recognition, feature classification and other operations to achieve sleep monitoring. At the same time, the DSP core sets the control parameters according to the sleep state monitoring results, and displays multi-modal physiological signals and output control parameters in real time. Get rid of the dependence of traditional computers and realize the portability of the system;
另一方面,本实施例中的装置不仅能够监测睡眠状态,对睡眠质量进行分类,而且能够针对性的采用微电流、光、温度、体感按摩等方式进行实施调控,帮助使用者提高睡眠质量。On the other hand, the device in this embodiment can not only monitor sleep status and classify sleep quality, but can also implement adjustments in specific ways such as micro-current, light, temperature, and somatosensory massage to help users improve sleep quality.
实施例2Example 2
基于实施例1中的装置,本实施例中还提供一种基于人体多模信号的睡眠监测调控方法,该方法包括以下步骤:Based on the device in Embodiment 1, this embodiment also provides a sleep monitoring and control method based on human multi-mode signals, and the method includes the following steps:
S1:采集生理信号;S1: Collect physiological signals;
生理信号包括脑电信号、心电信号、眼电信号、呼吸信号、体温信号和体动信号;Physiological signals include brain electrical signals, electrocardiographic signals, eye electrical signals, respiration signals, body temperature signals and body movement signals;
本步骤中,通过干电极阵列测量监测使用者不同睡眠姿势下的脑电信号;In this step, the EEG signals of the user under different sleeping positions are measured and monitored by the dry electrode array;
S2:对生理信号进行分析,对睡眠状态进行监测;S2: Analyze physiological signals and monitor sleep status;
使用脑电信号、眼电信号、体动信号对睡眠状态、睡眠分期进行评价,使用心电信号、呼吸信号用于监测使用者身体状态,使用体温信号用于监测体温的变化;Use brain electrical signals, eye electrical signals, and body motion signals to evaluate sleep status and sleep stages, use electrocardiographic signals and respiratory signals to monitor the user's physical state, and use body temperature signals to monitor changes in body temperature;
具体地,本步骤中对睡眠状态、睡眠分期进行评价的步骤具体包括:Specifically, the step of evaluating the sleep state and sleep stage in this step specifically includes:
S21:采用自动分期法将脑电信号进行伪迹去除;S21: Use automatic staging method to remove artifacts from EEG signals;
S22:按照第一预设时间段对去除伪迹后的脑电信号分段,并对分段后的数据加Hamming窗,得到输入空间;S22: Segment the EEG signal after artifact removal according to the first preset time period, and add a Hamming window to the segmented data to obtain an input space;
S23:针对每段数据帧,分别提取时域特征、频域特征、时频特征及非线性特征构成25维特征空间;S23: For each data frame, extract time-domain features, frequency-domain features, time-frequency features, and nonlinear features to form a 25-dimensional feature space;
S24:将特征空间及常用分期标记组成训练集作为支持向量机模型的输入并训练分期模型;S24: Use the feature space and common staging markers to form a training set as the input of the support vector machine model and train the staging model;
S25:对分期模型的分类准确性和泛化性能进行测试并选择测试结果最优的模型作为自动分期模型。S25: Test the classification accuracy and generalization performance of the staging model and select the model with the best test result as the automatic staging model.
S3:根据监测结构调控睡眠环境。S3: Regulate the sleep environment according to the monitoring structure.
本实施例中,根据步骤S2中的监测结果,输出不同的调控参数,具体为:In this embodiment, according to the monitoring result in step S2, different control parameters are output, specifically:
S31:根据监测结果输出电流调控参数,实现对人脑不同区域的微电流刺激,调整睡眠状态;S31: Output current control parameters according to the monitoring results to achieve micro-current stimulation of different areas of the human brain and adjust sleep state;
在对人脑不同区域的微电流刺激时,还设置有保护方式,具体为同时预先设定阈值,当电流超过该阈值时,电路自动断电,有效保护人体;该阈值为人体能承受、且不会造成生理伤害的电流范围内;When stimulating the micro-current in different areas of the human brain, a protection method is also provided, specifically, a threshold is set in advance at the same time. When the current exceeds the threshold, the circuit is automatically powered off to effectively protect the human body; the threshold is the human body can withstand, and Within the current range that will not cause physical harm;
S31:根据监测结果输出光线调控参数,发出不同的光线;S31: Output light control parameters according to the monitoring results, and emit different lights;
S31:根据监测结果输出震动调控参数,发出不同强度或频率的震动;S31: Output vibration control parameters according to the monitoring results, and send out vibrations of different intensities or frequencies;
S31:根据监测结果输出温度调控参数调整睡眠环境温度。S31: Adjust the sleep environment temperature according to the monitoring result and output the temperature control parameter.
上面结合附图对本发明的实施例进行了描述,但是本发明并不局限于上述的具体实施方式,上述的具体实施方式仅仅是示意性的,而不是限制性的,本领域的普通技术人员在本发明的启示下,在不脱离本发明宗旨和权利要求所保护的范围情况下,还可做出很多形式,这些均属于本发明的保护之内。The embodiments of the present invention are described above with reference to the accompanying drawings, but the present invention is not limited to the above-mentioned specific embodiments. The above-mentioned specific embodiments are only illustrative and not restrictive. Those of ordinary skill in the art are Under the enlightenment of the present invention, many forms can be made without departing from the purpose of the present invention and the protection scope of the claims, and these all fall within the protection of the present invention.

Claims (10)

  1. 一种基于人体多模信号的睡眠监测调控装置,包括睡眠调控床,以及设置在所述睡眠调控床上的睡眠监测模块、睡眠调控模块,其特征在于,A sleep monitoring and regulating device based on human multi-mode signals, comprising a sleep regulating bed, and a sleep monitoring module and a sleep regulating module arranged on the sleep regulating bed, characterized in that:
    所述睡眠监测模块用于获取生理信号,并根据所述生理信号进行分析,对睡眠状态进行监测;其中,所述生理信号包括脑电信号、心电信号、眼电信号、呼吸信号、体温信号和体动信号;The sleep monitoring module is used to obtain physiological signals and analyze them according to the physiological signals to monitor the sleep state; wherein, the physiological signals include brain electrical signals, electrocardiographic signals, eye electrical signals, respiration signals, body temperature signals And body movement signals;
    所述睡眠调控模块与所述睡眠监测模块信号相连,用于根据监测结果,输出用于对睡眠环境进行调控的调控参数。The sleep control module is signal-connected with the sleep monitoring module, and is used for outputting control parameters for regulating the sleep environment according to the monitoring result.
  2. 根据权利要求1所述的装置,其特征在于,所述睡眠监测模块包括信号测量传感器、信号预处理单元、分析监测单元;The device according to claim 1, wherein the sleep monitoring module comprises a signal measurement sensor, a signal preprocessing unit, and an analysis monitoring unit;
    所述信号测量传感器用于采集所述生理信号;The signal measurement sensor is used to collect the physiological signal;
    所述信号预处理单元与所述信号测量传感器的输出端相连,用于将所述生理信号进行放大与滤波后转换为数字生理信号;The signal preprocessing unit is connected to the output terminal of the signal measurement sensor, and is used for amplifying and filtering the physiological signal and converting it into a digital physiological signal;
    所述分析监测单元与所述信号预处理单元相连,用于对所述数字生理信号进行特征提取、特征识别、特征分类,对睡眠状态进行监测The analysis and monitoring unit is connected to the signal preprocessing unit, and is used to perform feature extraction, feature recognition, and feature classification on the digital physiological signal, and monitor sleep status
  3. 根据权利要求1所述的装置,其特征在于,所述睡眠调控模块包括:微电流刺激单元、光线调节单元、体感震动单元、温度控制单元;其中,The device according to claim 1, wherein the sleep control module comprises: a micro-current stimulation unit, a light adjustment unit, a somatosensory vibration unit, and a temperature control unit; wherein,
    所述微电流刺激单元用于根据监测结果输出电流调控参数,实现对人脑不同区域的微电流刺激,调整睡眠状态;The micro-current stimulation unit is used to output current control parameters according to the monitoring result to realize the micro-current stimulation of different regions of the human brain and adjust the sleep state;
    所述光线调节单元用于根据监测结果输出光线调控参数,发出不同的光线;The light adjusting unit is used for outputting light adjusting parameters according to the monitoring result, and emitting different light;
    所述体感震动单元用于根据监测结果输出震动调控参数,发出不同强度或频率的震动;The somatosensory vibration unit is used to output vibration control parameters according to the monitoring result, and emit vibrations of different intensities or frequencies;
    所述温度控制单元用于根据监测结果输出温度调控参数调整睡眠环境温度。The temperature control unit is used to output temperature control parameters according to the monitoring result to adjust the sleep environment temperature.
  4. 根据权利要求1所述的装置,其特征在于,所述信号测量传感器包括干式电极阵列,所述干式电极阵列用于获取不同睡眠姿势下的脑电信号。The device according to claim 1, wherein the signal measurement sensor comprises a dry electrode array, and the dry electrode array is used to obtain EEG signals in different sleeping postures.
  5. 根据权利要求3所述的装置,其特征在于,所述微电流刺激单元包括过流保护电路,所述过流保护电路用于当经过电流超过预设阈值时,自动断电。The device according to claim 3, wherein the micro-current stimulation unit comprises an over-current protection circuit, and the over-current protection circuit is configured to automatically power off when the passing current exceeds a preset threshold.
  6. 根据权利要求2所述的装置,其特征在于,所述分析监测单元内设置有自动分期模型,所述自动分期模型用于对睡眠状态分类。The device according to claim 2, wherein an automatic staging model is provided in the analysis and monitoring unit, and the automatic staging model is used to classify the sleep state.
  7. 一种基于人体多模信号的睡眠监测调控方法,其特征在于,包括以下步骤:A sleep monitoring and regulation method based on human multi-mode signals, which is characterized in that it comprises the following steps:
    采集生理信号;所述生理信号包括脑电信号、心电信号、眼电信号、呼吸信号、体温信号和体动信号;Collect physiological signals; the physiological signals include brain electrical signals, electrocardiographic signals, eye electrical signals, respiration signals, body temperature signals, and body movement signals;
    对所述生理信号进行分析,对睡眠状态进行监测:使用所述脑电信号、所述眼电信号、所述体动信号对睡眠状态、睡眠分期进行评价,使用所述心电信号、所述呼吸信号用于监测使用者身体状态,使用所述体温信号用于监测体温的变化;Analyze the physiological signals and monitor the sleep state: use the brain electrical signal, the eye electrical signal, and the body movement signal to evaluate the sleep state and sleep stage, use the electrocardiographic signal, the The breathing signal is used to monitor the physical state of the user, and the body temperature signal is used to monitor changes in body temperature;
    根据监测结构调控睡眠环境。Regulate the sleep environment according to the monitoring structure.
  8. 根据权利要求7所述的方法,其特征在于,所述对睡眠状态、睡眠分期进行评价的步骤具体包括:The method according to claim 7, wherein the step of evaluating sleep state and sleep stage specifically comprises:
    采用自动分期法将所述脑电信号进行伪迹去除;Using an automatic staging method to remove artifacts from the EEG signal;
    按照第一预设时间段对去除伪迹后的脑电信号分段,并对分段后的数据加Hamming窗,得到输入空间;Segment the EEG signal after artifact removal according to the first preset time period, and add a Hamming window to the segmented data to obtain the input space;
    针对每段数据帧,分别提取时域特征、频域特征、时频特征及非线性特征构成25维特征空间;For each data frame, extract time-domain features, frequency-domain features, time-frequency features, and nonlinear features to form a 25-dimensional feature space;
    将所述特征空间及常用分期标记组成训练集作为支持向量机模型的输入并训练分期模型;Using the feature space and common staging markers to form a training set as the input of the support vector machine model, and training the staging model;
    对所述分期模型的分类准确性和泛化性能进行测试并选择测试结果最优的模型作为自动分期模型。The classification accuracy and generalization performance of the staging model are tested, and the model with the best test result is selected as the automatic staging model.
  9. 根据权利要求7所述的方法,其特征在于,所述根据监测结构调控睡眠环境的步骤具体包括:The method according to claim 7, wherein the step of regulating the sleep environment according to the monitoring structure specifically comprises:
    根据监测结果输出电流调控参数,实现对人脑不同区域的微电流刺激,调整睡眠状态;Output current control parameters according to the monitoring results to achieve micro-current stimulation of different areas of the human brain and adjust sleep status;
    根据监测结果输出光线调控参数,发出不同的光线;According to the monitoring results, output light control parameters and emit different lights;
    根据监测结果输出震动调控参数,发出不同强度或频率的震动;Output vibration control parameters according to the monitoring results, and send out vibrations of different intensities or frequencies;
    根据监测结果输出温度调控参数调整睡眠环境温度。According to the monitoring results, the temperature control parameters are output to adjust the sleep environment temperature.
  10. 根据权利要求7所述的方法,其特征在于,通过干式电极阵列采集不同睡眠姿势时的脑电信号。8. The method according to claim 7, wherein the EEG signals in different sleeping postures are collected through a dry electrode array.
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Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110946574A (en) * 2019-12-17 2020-04-03 电子科技大学 Sleep monitoring and sleep regulation and control device based on human multimode signal
RU206144U1 (en) * 2020-09-16 2021-08-25 Общество с ограниченной ответственностью "СЛИПО" (ООО "СЛИПО") Data registration and transmission unit for a human sleep monitoring system
CN112914576B (en) * 2020-09-30 2024-03-22 世耳医疗科技(上海)有限公司 Human body bioelectricity detection circuit, detection system and detection method

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010035860A (en) * 2008-08-06 2010-02-18 Denso Corp Sleep support system
TWM425645U (en) * 2011-10-14 2012-04-01 Bing-Hong Tang Sleep disorder correction auxiliary device
CN105231995A (en) * 2015-09-29 2016-01-13 无锡市润华碳晶地暖设备有限公司 Sleep system
CN108078565A (en) * 2017-12-14 2018-05-29 上海惠诚科教器械股份有限公司 A kind of sleep monitor feedback and the automatic improvement device of sleep
EP3517025A1 (en) * 2018-01-24 2019-07-31 Nokia Technologies Oy An apparatus and associated methods for adjusting a user's sleep
CN110946574A (en) * 2019-12-17 2020-04-03 电子科技大学 Sleep monitoring and sleep regulation and control device based on human multimode signal

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5206572A (en) * 1988-06-22 1993-04-27 Siemens Energy & Automation, Inc. Motor controller
US20050192727A1 (en) * 1994-05-09 2005-09-01 Automotive Technologies International Inc. Sensor Assemblies
JP2007175476A (en) * 2005-11-29 2007-07-12 Seishi Takagi Temperature-adjustable mat
CN104188638B (en) * 2014-09-09 2016-08-24 喜临门家具股份有限公司 A kind of sleep safeguards system
DE102016109524A1 (en) * 2015-12-30 2017-07-06 Dewertokin Gmbh Sleeping or rest furniture and electromotive furniture drive for such furniture and method for providing an information and / or warning signal by an electromotive furniture drive
CN205696853U (en) * 2016-04-06 2016-11-23 杭州电子科技大学 A kind of multifunctional baby cradle
CN111770706B (en) * 2017-12-28 2023-06-02 数眠公司 Bed with snore detection feature
CN110242427B (en) * 2019-04-17 2020-10-16 吉林大学 Ship engine monitoring system
CN110401754A (en) * 2019-07-25 2019-11-01 江门市蓬江区中道电子有限公司 A kind of lazyboot's smart mobile phone support
CN212213728U (en) * 2019-12-17 2020-12-25 电子科技大学 Sleep monitoring and sleep regulation and control device based on human multimode signal

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010035860A (en) * 2008-08-06 2010-02-18 Denso Corp Sleep support system
TWM425645U (en) * 2011-10-14 2012-04-01 Bing-Hong Tang Sleep disorder correction auxiliary device
CN105231995A (en) * 2015-09-29 2016-01-13 无锡市润华碳晶地暖设备有限公司 Sleep system
CN108078565A (en) * 2017-12-14 2018-05-29 上海惠诚科教器械股份有限公司 A kind of sleep monitor feedback and the automatic improvement device of sleep
EP3517025A1 (en) * 2018-01-24 2019-07-31 Nokia Technologies Oy An apparatus and associated methods for adjusting a user's sleep
CN110946574A (en) * 2019-12-17 2020-04-03 电子科技大学 Sleep monitoring and sleep regulation and control device based on human multimode signal

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