WO2021103067A1 - 根据有创血压获取舒张压、收缩压极值点的方法及系统 - Google Patents

根据有创血压获取舒张压、收缩压极值点的方法及系统 Download PDF

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WO2021103067A1
WO2021103067A1 PCT/CN2019/122911 CN2019122911W WO2021103067A1 WO 2021103067 A1 WO2021103067 A1 WO 2021103067A1 CN 2019122911 W CN2019122911 W CN 2019122911W WO 2021103067 A1 WO2021103067 A1 WO 2021103067A1
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blood pressure
diastolic
systolic
initial
invasive
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PCT/CN2019/122911
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English (en)
French (fr)
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孔祥通
陈艾骎
霍云飞
刘广志
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苏州润迈德医疗科技有限公司
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
    • A61B5/021—Measuring pressure in heart or blood vessels
    • A61B5/0215—Measuring pressure in heart or blood vessels by means inserted into the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
    • A61B5/021—Measuring pressure in heart or blood vessels
    • A61B5/02141—Details of apparatus construction, e.g. pump units or housings therefor, cuff pressurising systems, arrangements of fluid conduits or circuits
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
    • A61B2562/02—Details of sensors specially adapted for in-vivo measurements
    • A61B2562/0247—Pressure sensors

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  • the present invention relates to the technical field of coronary artery medicine, in particular to a method and system for obtaining diastolic and systolic blood pressure extreme points according to invasive blood pressure, coronary artery vascular evaluation parameters and storage medium.
  • Blood pressure monitoring methods are divided into two types: invasive and non-invasive.
  • the invasive monitoring method is clinically regarded as the gold standard because it is more accurate and reliable.
  • Invasive blood pressure is called the direct measurement method, which is to establish a pressure transmission channel through physiological saline with the measurement site, and use a pressure sensor to obtain the instantaneous pressure.
  • Coronary artery blood vessel evaluation parameters such as blood flow reserve mainly use systolic blood pressure, diastolic blood pressure and mean blood pressure, but the instantaneous blood pressure measured by the pressure sensor cannot accurately determine the minimum systolic blood pressure and the maximum diastolic blood pressure, resulting in The calculation of coronary vascular assessment parameters is inaccurate.
  • the present invention provides a method and system for obtaining extreme points of diastolic blood pressure and systolic pressure according to invasive blood pressure, so as to solve the problem that the instantaneous blood pressure measured by a pressure sensor in the prior art cannot accurately determine the minimum points of systolic blood pressure and The maximum value of diastolic blood pressure leads to the problem of inaccurate calculation of coronary vascular evaluation parameters.
  • the present invention provides a method for obtaining extreme points of diastolic blood pressure and extreme systolic blood pressure based on real-time invasive blood pressure, including:
  • the initial minimum systolic blood pressure point is compared with the systolic blood pressure threshold, and the initial minimum systolic blood pressure point that does not meet the condition is eliminated, and the systolic blood pressure extreme point is obtained after updating.
  • the above-mentioned method of obtaining extreme points of diastolic blood pressure and extreme points of systolic blood pressure based on real-time invasive blood pressure includes:
  • the invasive blood pressure P t1 at time t 1 is on the downward trend line of the invasive blood pressure waveform, and all the invasive blood pressure values on the downward trend line that meet the conditions are calculated
  • the maximum value of invasive blood pressure is obtained as the initial maximum point of diastolic blood pressure; among them, P t1 represents the invasive blood pressure at t 1 , P t0 represents the invasive blood pressure at t 0 immediately before t 1 , and P t2 represents a t 1 adjacent to the time t 2 of IBP.
  • the above-mentioned method of obtaining extreme points of diastolic blood pressure and extreme points of systolic blood pressure based on real-time invasive blood pressure includes:
  • the invasive blood pressure P t1 at time t 1 is on the rising trend line of the invasive blood pressure waveform, and all the invasive blood pressure values on the rising trend line that meet the conditions are calculated
  • the minimum value of invasive blood pressure is obtained as the initial minimum point of systolic blood pressure; among them, P t1 represents the invasive blood pressure at t 1 , P t0 represents the invasive blood pressure at t 0 immediately before t 1 , and P t2 represents a t 1 adjacent to the time t 2 of IBP.
  • the above-mentioned method for obtaining extremum points of diastolic blood pressure and extremum points of systolic blood pressure according to real-time invasive blood pressure said obtaining diastolic blood pressure according to the initial extremum points of diastolic blood pressure and the initial extremum points of systolic blood pressure respectively
  • Methods of threshold and systolic blood pressure threshold include:
  • a, b are constants expressed, P represents diastolic diastolic threshold, P represents the systolic contraction threshold value, P I denotes an initial diastolic maxima, P J represents an initial minimum point systolic pressure.
  • the value of a is 1/8 to 1/2
  • the value of b is 1/2 to 7/8.
  • the above-mentioned method for obtaining extreme points of diastolic blood pressure and extreme systolic blood pressure according to real-time invasive blood pressure after the real-time reading of the invasive blood pressure of the coronary arteries, the maximum value of the invasive blood pressure is obtained Before the initial maximum value of diastolic blood pressure, it also includes: generating the invasive blood pressure waveform in the time domain according to the read invasive blood pressure value and time;
  • the initial maximum point of diastolic blood pressure and the initial minimum point of systolic blood pressure are obtained.
  • this application provides a method for obtaining coronary vascular evaluation parameters, including:
  • the blood vessel evaluation parameters are obtained, including: mean pressure and mean arterial pressure.
  • this application provides a system for obtaining extreme points of diastolic blood pressure and extreme systolic blood pressure based on real-time invasive blood pressure, including: blood pressure acquisition device, initial diastolic blood pressure device, initial systolic blood pressure device, and diastolic blood pressure threshold device , Systolic blood pressure threshold device, diastolic blood pressure extreme value point acquisition device and systolic pressure extreme value point acquisition device;
  • the systolic blood pressure extreme point acquisition device is connected to the systolic blood pressure threshold device and the initial systolic blood pressure device,
  • the blood pressure acquisition devices are all connected to the initial diastolic blood pressure device and the initial systolic blood pressure device, and are used to read the invasive blood pressure of the coronary arteries in real time;
  • the initial diastolic blood pressure device is used to obtain the maximum value of the invasive blood pressure as the initial maximum value point of the diastolic blood pressure after comparison according to the real-time invasive blood pressure obtained by the blood pressure acquisition device;
  • the initial systolic blood pressure device is used to obtain the minimum value of the invasive blood pressure as the initial minimum value point of the systolic blood pressure after comparison according to the real-time invasive blood pressure obtained by the blood pressure acquisition device;
  • the diastolic blood pressure threshold device is connected to the initial diastolic blood pressure device and the initial systolic blood pressure device, and is configured to obtain the diastolic blood pressure threshold according to the initial maximum point of diastolic blood pressure and the minimum point of initial systolic blood pressure;
  • the systolic blood pressure threshold device is connected with the initial diastolic blood pressure device and the initial systolic blood pressure device, and is used to obtain the systolic blood pressure threshold according to the initial maximum point of diastolic blood pressure and the minimum point of initial systolic blood pressure;
  • the diastolic pressure extreme point acquisition device is connected to the diastolic pressure threshold device and the initial diastolic blood pressure device, and is used to compare the initial maximum diastolic pressure point with the diastolic pressure threshold, and eliminate the initial diastolic pressure threshold.
  • the initial maximum point of diastolic blood pressure where the diastolic blood pressure device does not meet the conditions will be updated to obtain the extreme point of diastolic blood pressure;
  • the systolic blood pressure extreme point acquisition device is connected to the systolic blood pressure threshold device and the initial systolic blood pressure device, and is used to compare the initial minimum systolic blood pressure point with the systolic blood pressure threshold, and eliminate the initial systolic blood pressure.
  • the initial minimum point of the systolic blood pressure that the systolic pressure device does not meet the conditions will be updated to obtain the extreme point of the systolic blood pressure.
  • the blood pressure collection device includes: a blood pressure collection unit and a connection unit, the blood pressure collection unit and the connection unit Removable connection;
  • the blood pressure acquisition unit includes a housing, a blood pressure sensor, an information transmission structure, and a first connection structure.
  • the blood pressure sensor, the information transmission structure, and the first connection structure are all disposed in the housing, and the first connection structure is connected to the first connection structure.
  • the connection unit includes a main body, a second connection structure, and a third connection structure.
  • the second connection structure and the third connection structure are both disposed on the main body, and the second connection structure is connected to the first connection structure.
  • the structure can be detached and connected;
  • the third connection structure is connected with the initial diastolic pressure device and the initial systolic pressure device.
  • the present application provides a computer storage medium.
  • a computer program is executed by a processor, the above-mentioned method of obtaining diastolic blood pressure extreme points and systolic blood pressure extreme points based on real-time invasive blood pressure is realized.
  • This application provides a method for obtaining extreme points of diastolic blood pressure and systolic blood pressure according to invasive blood pressure, by initially obtaining initial extreme points of diastolic blood pressure and systolic blood pressure, and obtaining threshold values of diastolic blood pressure and systolic blood pressure respectively according to the extreme points; The extreme points are compared with the threshold, the extreme points that do not meet the conditions are eliminated, the extreme points of diastolic and systolic blood pressure are updated, and the accuracy of the extreme points of diastolic and systolic blood pressure is improved. The calculation of the evaluation parameters improves the accuracy.
  • Fig. 1 is a flowchart of a method for obtaining extreme points of diastolic blood pressure and extreme systolic blood pressure according to real-time invasive blood pressure according to the present application;
  • Fig. 2 is a structural block diagram of a system for obtaining extreme points of diastolic blood pressure and extreme systolic blood pressure according to real-time invasive blood pressure;
  • Figure 3 is a schematic diagram of the structure of the blood pressure collection device of the application.
  • Blood pressure collection device 100 Blood pressure collection unit 110, housing 111, first connection structure 112, connection unit 120, main body 121, second connection structure 122, third connection structure 123, initial diastolic blood pressure device 200, initial systolic blood pressure device 300 , The diastolic blood pressure threshold device 400, the systolic blood pressure threshold device 500, the diastolic blood pressure extreme value point acquisition device 600, and the systolic blood pressure extreme value point acquisition device 700.
  • the present application provides a method for obtaining extreme points of diastolic blood pressure and extreme systolic blood pressure based on real-time invasive blood pressure, including:
  • S200 Obtain the maximum value of invasive blood pressure as the initial maximum value of diastolic blood pressure, including:
  • the invasive blood pressure P t1 at t 1 is on the downward trend line of the invasive blood pressure waveform, and all the invasive blood pressure values on the downward trend line that meet the conditions are compared to obtain the The maximum value of invasive blood pressure is taken as the initial maximum point of diastolic blood pressure; among them, P t1 represents the invasive blood pressure at t 1 , P t0 represents the invasive blood pressure at t 0 immediately before t 1 , and P t2 represents the same as t 1 Invasive blood pressure at t 2 immediately after the neighbor;
  • S300 Obtain the minimum value of invasive blood pressure as the initial minimum point of systolic blood pressure, including:
  • the invasive blood pressure P t1 at t 1 is on the rising trend line of the invasive blood pressure waveform, and all the invasive blood pressure values on the rising trend line that meet the conditions are compared to obtain the The minimum value of invasive blood pressure is taken as the initial minimum point of systolic blood pressure; among them, P t1 represents the invasive blood pressure at t 1 , P t0 represents the invasive blood pressure at t 0 immediately before t 1 , and P t2 represents the same as t 1 Invasive blood pressure at t 2 immediately after the neighbor;
  • S400 Obtain the diastolic blood pressure threshold and the systolic blood pressure threshold respectively according to the initial maximum point of diastolic blood pressure and the initial minimum point of systolic blood pressure, including:
  • a and b both represent constants
  • P diastole represents the diastolic threshold
  • P contraction represents the systolic threshold
  • P i represents the initial maximum point of diastolic blood pressure
  • P j represents the initial minimum point of systolic blood pressure
  • S500 Compare the initial maximum point of diastolic blood pressure with the threshold value of diastolic blood pressure, eliminate the initial maximum point of diastolic blood pressure that does not meet the conditions, and obtain the extreme point of diastolic blood pressure after updating, including:
  • the initial maximum value of diastolic blood pressure is greater than the threshold value of diastolic blood pressure, reselect the extreme value point of diastolic blood pressure; compare the diastolic blood pressure value at the peak position with the diastolic blood pressure threshold value in all the downward trend lines in S200, and select the peak value The diastolic blood pressure value of the position is less than the descending trend line of the diastolic blood pressure threshold, and the maximum diastolic blood pressure point is selected from the selected downward trend line as the extreme diastolic blood pressure point;
  • the initial maximum point of diastolic blood pressure is less than or equal to the diastolic blood pressure threshold, the initial maximum point of diastolic blood pressure is the diastolic blood pressure threshold, and there is no need to reselect it;
  • S600 Compare the initial minimum point of systolic blood pressure with the systolic blood pressure threshold, remove the initial minimum point of systolic blood pressure that does not meet the conditions, and obtain the extreme point of systolic blood pressure after updating, including:
  • the initial minimum point of systolic blood pressure is less than the systolic blood pressure threshold, reselect the extreme point of systolic blood pressure; compare the systolic blood pressure value at the trough position with the systolic blood pressure threshold in all the upward trend lines in S300, and select the trough
  • the systolic blood pressure value of the position is less than the rising trend line of the systolic blood pressure threshold, and the minimum systolic blood pressure point is selected from the selected rising trend line as the systolic blood pressure extreme point;
  • the initial minimum point of the systolic blood pressure is less than or equal to the systolic blood pressure threshold, the initial minimum point of the systolic blood pressure is the systolic blood pressure threshold, and there is no need to reselect it.
  • This application initially obtains the initial extreme points of diastolic blood pressure and systolic blood pressure, and obtains the threshold values of diastolic blood pressure and systolic blood pressure respectively according to the extreme points;
  • the extreme points of pressure and systolic pressure are updated, which improves the accuracy of the extreme points of diastolic and systolic blood pressure, and improves the accuracy of the calculation of the subsequent coronary artery vascular evaluation parameters.
  • the method further includes: generating an invasive blood pressure waveform in the time domain according to the read invasive blood pressure value and time;
  • the initial maximum point of diastolic blood pressure and the initial minimum point of systolic blood pressure are obtained.
  • an invasive blood pressure waveform is set, the patient can view it through an external display screen, and the vision is stronger; if only the data is collected, the blood pressure waveform is not generated, which reduces the data calculation and makes the calculation faster.
  • This application provides a method for obtaining coronary artery vascular evaluation parameters, including:
  • vascular evaluation parameters including: mean pressure and mean arterial pressure.
  • the present application provides a system for obtaining extreme points of diastolic blood pressure and extreme systolic blood pressure based on real-time invasive blood pressure, including: blood pressure collecting device 100, initial diastolic blood pressure device 200, and initial systolic blood pressure device 300 , Diastolic blood pressure threshold device 400, systolic blood pressure threshold device 500, diastolic blood pressure extreme value point acquisition device 600, and systolic pressure extreme value point acquisition device 700; both systolic pressure extreme value point acquisition device 700 and systolic blood pressure threshold device 500, initial systolic blood pressure
  • the blood pressure collection device 100 is connected to the initial diastolic blood pressure device 200 and the initial systolic blood pressure device 300 for real-time reading of the invasive blood pressure of the coronary arteries; the initial diastolic blood pressure device 200 is used for real-time data obtained by the blood pressure collection device.
  • the maximum value of invasive blood pressure is obtained as the initial maximum value of diastolic blood pressure;
  • the initial systolic blood pressure device 300 is used to obtain the real-time invasive blood pressure obtained by the blood pressure acquisition device, and after comparison, obtain the minimum value of invasive blood pressure As the initial minimum point of systolic blood pressure;
  • the diastolic blood pressure threshold device 400 is connected to the initial diastolic blood pressure device 200 and the initial systolic blood pressure device 300, and is used to obtain diastolic blood pressure according to the initial maximum point of diastolic blood pressure and the minimum point of initial systolic pressure Threshold;
  • the systolic blood pressure threshold device 500 is connected to the initial diastolic blood pressure device 200 and the initial systolic blood pressure device 300, and is used to obtain the systolic blood pressure threshold according to the initial maximum point of diastolic blood pressure and the minimum initial systolic
  • the diastolic blood pressure extreme point is obtained after the update; the systolic pressure extreme point acquisition device 700 is connected to the systolic blood pressure threshold device 500 and the initial systolic blood pressure device 300, and is used to compare the initial minimum point of systolic blood pressure with the systolic blood pressure threshold, and eliminate The initial minimum point of systolic blood pressure whose initial systolic pressure device does not meet the conditions will be updated to obtain the extreme point of systolic blood pressure.
  • the blood pressure collection device 100 includes: a blood pressure collection unit 110 and a connection unit 120.
  • the blood pressure collection unit 110 and the connection unit 120 are detachably connected;
  • the blood pressure collection unit 110 includes a housing 111, The blood pressure sensor, the information transmission structure, and the first connection structure 112.
  • the blood pressure sensor, the information transmission structure, and the first connection structure 112 are all disposed in the housing 111, and the first connection structure 112 is connected to the information transmission structure;
  • the connection unit 120 includes a main body 121 ,
  • the second connection structure 122 and the third connection structure 123, the second connection structure 122 and the third connection structure 123 are both disposed on the main body 121, the second connection structure 122 and the first connection structure 112 are detachably connected;
  • the third connection structure 123 is connected to the initial diastolic pressure device 200 and the initial systolic pressure device 300.
  • This application includes a blood pressure acquisition unit and a connection unit that can be detachably connected.
  • the integrated structure is divided into two parts, which simplifies the installation process, saves costs, and facilitates replacement of parts; and the housing, blood pressure sensor, information transmission structure and the first connection
  • the structure is set as a whole, which not only realizes the collection and transmission of the blood pressure sensor, but also improves the sealing of the blood pressure sensor; the connection device connected with the external equipment is set separately, which reduces the volume of packaging and transportation, saves costs, and installs easy.
  • the present application provides a computer storage medium, and when a computer program is executed by a processor, the above-mentioned method of obtaining extreme points of diastolic blood pressure and extreme systolic blood pressure based on real-time invasive blood pressure is realized.

Abstract

本申请提供了一种根据有创血压获取舒张压、收缩压极值点的方法及系统，包括：实时读取冠状动脉的有创血压；获得有创血压的最大值和最小值分别作为舒张压初始极大值点和收缩压初始极小值点；根据舒张压初始极大值点和收缩压初始极小值点分别获取舒张压阈值和收缩压阈值；将极大值点、极小值点分别与阈值比较，剔除不满足条件的舒张压值和收缩压值，更新后获得舒张压极值点、收缩压极值点。本申请通过初步获得舒张压、收缩压的初始极值点、舒张压和收缩压的阈值；将极值点与阈值进行比较，剔除不满足条件的极值点，对舒张压和收缩压的极值点进行更新，提高了舒张压和收缩压极值点的准确性，为后面冠状动脉血管评定参数的计算提高了准确性。

Description

根据有创血压获取舒张压、收缩压极值点的方法及系统 技术领域
本发明涉及冠状动脉医学技术领域，特别是涉及一种根据有创血压获取舒张压、收缩压极值点的方法及系统、冠状动脉血管评定参数及存储介质。
背景技术
血压监测方式分为有创和无创两种。有创监测的方式因其更加准确和可靠被临床作为金标准。有创血压称为直接测量法，是通过与测量部位通过生理盐水建立压力传递通道，使用压力传感器获取瞬时压力。
血流储备分数等冠状动脉血管评定参数主要采用收缩压、舒张压和平均压，但是通过压力传感器测得的瞬时血压无法准确的判断出收缩压极小值点和舒张压极大值点，导致冠状动脉血管评定参数的计算不准确。
发明内容
本发明提供了一种根据有创血压获取舒张压、收缩压极值点的方法及系统，以解决现有技术中通过压力传感器测得的瞬时血压无法准确的判断出收缩压极小值点和舒张压极大值点，导致冠状动脉血管评定参数的计算不准确的问题。
为实现上述目的，本发明提供了一种根据实时有创血压获取舒张压极值点和收缩压极值点的方法，包括：
实时读取冠状动脉的有创血压；
获得有创血压的最大值作为舒张压初始极大值点；
获得有创血压的最小值作为收缩压初始极小值点；
根据所述舒张压初始极大值点和所述收缩压初始极小值点分别获取舒张压阈值和收缩压阈值；
将所述舒张压初始极大值点与所述舒张压阈值比较，剔除不满足条件的舒张压初始极大值点，更新后获得舒张压极值点；
将所述收缩压初始极小值点与所述收缩压阈值比较，剔除不满足条件的收缩压初始极小值点，更新后获得收缩压极值点。
可选地，上述的根据实时有创血压获取舒张压极值点和收缩压极值点的方法，所述获得有创血压的最大值作为舒张压初始极大值点的方法包括：
如果P t0＞P t1＞P t2，则t 1时刻的有创血压P t1处于所述有创血压波形的下降趋势线上，将所有满足条件的所述下降趋势线上的有创血压值进行比较，获得有创血压的最大值作为舒张压初始极大值点；其中，P t1表示t 1时刻的有创血压，P t0表示与t 1相邻前一时刻t 0的有创血压，P t2表示与t 1相邻后一时刻t 2的有创血压。
可选地，上述的根据实时有创血压获取舒张压极值点和收缩压极值点的方法，所述获得有创血压的最小值作为收缩压初始极小值点的方法包括：
如果P t0＜P t1＜P t2，则t 1时刻的有创血压P t1处于所述有创血压波形的上升趋势线上，将所有满足条件的所述上升趋势线上的有创血压值进行比较，获得有创血压的最小值作为收缩压初始极小值点；其 中，P t1表示t 1时刻的有创血压，P t0表示与t 1相邻前一时刻t 0的有创血压，P t2表示与t 1相邻后一时刻t 2的有创血压。
可选地，上述的根据实时有创血压获取舒张压极值点和收缩压极值点的方法，所述根据所述舒张压初始极值点和所述收缩压初始极值点分别获取舒张压阈值和收缩压阈值的方法包括：
P 舒张＝a P i+b P j；
P 收缩＝b P i+a P j；
a+b＝1；
a＞0，b＞0；
其中，a、b均表示常数，P 舒张表示舒张期阈值，P 收缩表示收缩期阈值，P i表示舒张压初始极大值点，P j表示收缩压初始极小值点。
可选地，上述的根据实时有创血压获取舒张压极值点和收缩压极值点的方法，所述a的取值为1/8～1/2，b的取值为1/2～7/8。
可选地，上述的根据实时有创血压获取舒张压极值点和收缩压极值点的方法，所述a＝1/4，b＝3/4。
可选地，上述的根据实时有创血压获取舒张压极值点和收缩压极值点的方法，在所述实时读取冠状动脉的有创血压之后，在所述获得有创血压的最大值作为舒张压初始极大值点之前，还包括：根据读取的有创血压值与时间生成时间域下的有创血压波形；
如果P t1＜P t0，P t1＜P t2，则t 1时刻的有创血压P t1处于所述有创血压波形的波谷位置；
如果P t0＜P t1＜P t2，则t 1时刻的有创血压P t1处于所述有创血压波形的上升趋势线上；
如果P t0＞P t1＞P t2，则t 1时刻的有创血压P t1处于所述有创血压波形的下降趋势线上；
如果P t1＞P t0，P t1＞P t2，则t 1时刻的有创血压P t1处于所述有创血压波形的波峰位置；
根据所述有创血压波形的波峰、波谷，以及上升趋势线、下降趋势线，获得舒张压初始极大值点和收缩压初始极小值点。
第二方面，本申请提供了一种获取冠状动脉血管评定参数的方法，包括：
上述的根据实时有创血压获取舒张压极值点和收缩压极值点的方法；
根据所述舒张压极值点和收缩压极值点获得血管评定参数，包括：平均压、平均动脉压。
第三方面，本申请提供了一种根据实时有创血压获取舒张压极值点和收缩压极值点的系统，包括：血压采集装置、初始舒张压装置、初始收缩压装置、舒张压阈值装置、收缩压阈值装置、舒张压极值点获取装置和收缩压极值点获取装置；
所述收缩压极值点获取装置均与所述收缩压阈值装置、所述初始收缩压装置连接，
所述血压采集装置均与所述初始舒张压装置、所述初始收缩压装置连接，用于实时读取冠状动脉的有创血压；
所述初始舒张压装置，用于根据所述血压采集装置获得的实时有创血压，经过比较，获得有创血压的最大值作为舒张压初始极大值点；
所述初始收缩压装置，用于根据所述血压采集装置获得的实时有创血压，经过比较，获得有创血压的最小值作为收缩压初始极小值点；
所述舒张压阈值装置均与所述初始舒张压装置、所述初始收缩压装置连接，用于根据所述舒张压初始极大值点和初始收缩压极小值点获取舒张压阈值；
所述收缩压阈值装置均与所述初始舒张压装置、所述初始收缩压装置连接，用于根据所述舒张压初 始极大值点和初始收缩压极小值点获取收缩压阈值；
所述舒张压极值点获取装置均与所述舒张压阈值装置、所述初始舒张压装置连接，用于将所述舒张压初始极大值点与所述舒张压阈值比较，剔除所述初始舒张压装置不满足条件的舒张压初始极大值点，更新后获得舒张压极值点；
所述收缩压极值点获取装置均与所述收缩压阈值装置、所述初始收缩压装置连接，用于将所述收缩压初始极小值点与所述收缩压阈值比较，剔除所述初始收缩压装置不满足条件的收缩压初始极小值点，更新后获得收缩压极值点。
可选地，上述的根据实时有创血压获取舒张压极值点和收缩压极值点的系统，所述血压采集装置包括：血压采集单元和连接单元，所述血压采集单元与所述连接单元可拆卸连接；
所述血压采集单元包括壳体、血压传感器、信息传输结构和第一连接结构，所述血压传感器、信息传输结构和第一连接结构均设置于所述壳体内，所述第一连接结构与所述信息传输结构连接；
所述连接单元包括主体、第二连接结构和第三连接结构，所述第二连接结构与所述第三连接结构均设置于所述主体上，所述第二连接结构与所述第一连接结构可拆卸连接；
所述第三连接结构均与所述初始舒张压装置、所述初始收缩压装置连接。
第四方面，本申请提供了一种计算机存储介质，计算机程序被处理器执行时实现上述的根据实时有创血压获取舒张压极值点和收缩压极值点的方法。
本申请实施例提供的方案带来的有益效果至少包括：
本申请提供了一种根据有创血压获取舒张压、收缩压极值点的方法，通过初步获得舒张压、收缩压的初始极值点，根据极值点分别获取舒张压和收缩压的阈值；将极值点与阈值进行比较，剔除不满足条件的极值点，对舒张压和收缩压的极值点进行更新，提高了舒张压和收缩压极值点的准确性，为后面冠状动脉血管评定参数的计算提高了准确性。
附图说明
此处所说明的附图用来提供对本发明的进一步理解，构成本发明的一部分，本发明的示意性实施例及其说明用于解释本发明，并不构成对本发明的不当限定。在附图中：
图1为本申请的根据实时有创血压获取舒张压极值点和收缩压极值点的方法的流程图；
图2为本申请的根据实时有创血压获取舒张压极值点和收缩压极值点的系统的结构框图；
图3为本申请的血压采集装置的结构示意图；
下面对附图标记进行说明：
血压采集装置100，血压采集单元110，壳体111，第一连接结构112，连接单元120，主体121，第二连接结构122，第三连接结构123，初始舒张压装置200，初始收缩压装置300，舒张压阈值装置400，收缩压阈值装置500，舒张压极值点获取装置600，收缩压极值点获取装置700。
具体实施方式
为使本发明的目的、技术方案和优点更加清楚，下面将结合本发明具体实施例及相应的附图对本发明技术方案进行清楚、完整地描述。显然，所描述的实施例仅是本发明一部分实施例，而不是全部的实施例。基于本发明中的实施例，本领域普通技术人员在没有做出创造性劳动前提下所获得的所有其他实施例，都属于本发明保护的范围。
以下将以图式揭露本发明的多个实施方式，为明确说明起见，许多实务上的细节将在以下叙述中一并说明。然而，应了解到，这些实务上的细节不应用以限制本发明。也就是说，在本发明的部分实施方 式中，这些实务上的细节是非必要的。此外，为简化图式起见，一些习知惯用的结构与组件在图式中将以简单的示意的方式绘示之。
在实际临床使用过程中，血压的测量往往会受到患者的移动或者压力导管晃动等从而使血压数据大幅跳动、不稳定，且出现都是随机出现。通过压力传感器测得的瞬时血压无法准确的判断出收缩压极小值点和舒张压极大值点，导致冠状动脉血管评定参数的计算不准确。
实施例1：
如图1所示，本申请提供了一种根据实时有创血压获取舒张压极值点和收缩压极值点的方法，包括：
S100，实时读取冠状动脉的有创血压；
S200，获得有创血压的最大值作为舒张压初始极大值点，包括：
如果P t0＞P t1＞P t2，则t 1时刻的有创血压P t1处于有创血压波形的下降趋势线上，将所有满足条件的下降趋势线上的有创血压值进行比较，获得有创血压的最大值作为舒张压初始极大值点；其中，P t1表示t 1时刻的有创血压，P t0表示与t 1相邻前一时刻t 0的有创血压，P t2表示与t 1相邻后一时刻t 2的有创血压；
S300，获得有创血压的最小值作为收缩压初始极小值点，包括：
如果P t0＜P t1＜P t2，则t 1时刻的有创血压P t1处于有创血压波形的上升趋势线上，将所有满足条件的上升趋势线上的有创血压值进行比较，获得有创血压的最小值作为收缩压初始极小值点；其中，P t1表示t 1时刻的有创血压，P t0表示与t 1相邻前一时刻t 0的有创血压，P t2表示与t 1相邻后一时刻t 2的有创血压；
S400，根据舒张压初始极大值点和收缩压初始极小值点分别获取舒张压阈值和收缩压阈值，包括：
P 舒张＝a P i+b P j；
P 收缩＝b P i+a P j；
a+b＝1；
a＞0，b＞0；
其中，a、b均表示常数，P 舒张表示舒张期阈值，P 收缩表示收缩期阈值，P i表示舒张压初始极大值点，P j表示收缩压初始极小值点；
S500，将舒张压初始极大值点与舒张压阈值比较，剔除不满足条件的舒张压初始极大值点，更新后获得舒张压极值点，包括：
如果舒张压初始极大值点大于舒张压阈值，则重新选取舒张压极值点；将S200中的所有下降趋势线中，分别将位于波峰位置的舒张压值与舒张压阈值进行比较，选取波峰位置的舒张压值小于舒张压阈值的下降趋势线，从被选择的下降趋势线中选取舒张压最大值点作为舒张压极值点；
如果舒张压初始极大值点小于等于舒张压阈值，则该舒张压初始极大值点即为舒张压阈值，无需重新选取；
S600，将收缩压初始极小值点与收缩压阈值比较，剔除不满足条件的收缩压初始极小值点，更新后获得收缩压极值点，包括：
如果收缩压初始极小值点小于收缩压阈值，则重新选取收缩压极值点；将S300中的所有上升趋势线中，分别将位于波谷位置的收缩压值与收缩压阈值进行比较，选取波谷位置的收缩压值小于收缩压阈值的上升趋势线，从被选择的上升趋势线中选取收缩压最小值点作为收缩压极值点；
如果收缩压初始极小值点小于等于收缩压阈值，则该收缩压初始极小值点即为收缩压阈值，无需重新选取。
本申通过初步获得舒张压、收缩压的初始极值点，根据极值点分别获取舒张压和收缩压的阈值；将 极值点与阈值进行比较，剔除不满足条件的极值点，对舒张压和收缩压的极值点进行更新，提高了舒张压和收缩压极值点的准确性，为后面冠状动脉血管评定参数的计算提高了准确性。
本申请的一个实施例中，a的取值为1/8～1/2，b的取值为1/2～7/8；优选地，a＝1/4，b＝3/4。
本申请的一个实施例中，在S100之后，在S200之前，还包括：根据读取的有创血压值与时间生成时间域下的有创血压波形；
如果P t1＜P t0，P t1＜P t2，则t 1时刻的有创血压P t1处于有创血压波形的波谷位置；
如果P t0＜P t1＜P t2，则t 1时刻的有创血压P t1处于有创血压波形的上升趋势线上；
如果P t0＞P t1＞P t2，则t 1时刻的有创血压P t1处于有创血压波形的下降趋势线上；
如果P t1＞P t0，P t1＞P t2，则t 1时刻的有创血压P t1处于有创血压波形的波峰位置；
根据有创血压波形的波峰、波谷，以及上升趋势线、下降趋势线，获得舒张压初始极大值点和收缩压初始极小值点。
本申请中，如果设置有创血压波形，通过外部的显示屏便于患者查看，视觉性更强；如果只采集数据，而不生成血压波形，减少了数据的运算，运算更快。
本申请提供了一种获取冠状动脉血管评定参数的方法，包括：
上述的根据实时有创血压获取舒张压极值点和收缩压极值点的方法；
根据舒张压极值点和收缩压极值点获得血管评定参数，包括：平均压、平均动脉压。
实施例2：
如图2所示，本申请提供了一种根据实时有创血压获取舒张压极值点和收缩压极值点的系统，包括：血压采集装置100、初始舒张压装置200、初始收缩压装置300、舒张压阈值装置400、收缩压阈值装置500、舒张压极值点获取装置600和收缩压极值点获取装置700；收缩压极值点获取装置700均与收缩压阈值装置500、初始收缩压装置300连接，血压采集装置100均与初始舒张压装置200、初始收缩压装置300连接，用于实时读取冠状动脉的有创血压；初始舒张压装置200用于根据血压采集装置获得的实时有创血压，经过比较，获得有创血压的最大值作为舒张压初始极大值点；初始收缩压装置300用于根据血压采集装置获得的实时有创血压，经过比较，获得有创血压的最小值作为收缩压初始极小值点；舒张压阈值装置400均与初始舒张压装置200、初始收缩压装置300连接，用于根据舒张压初始极大值点和初始收缩压极小值点获取舒张压阈值；收缩压阈值装置500均与初始舒张压装置200、初始收缩压装置300连接，用于根据舒张压初始极大值点和初始收缩压极小值点获取收缩压阈值；舒张压极值点获取装置600均与舒张压阈值装置400、初始舒张压装置200连接，用于将舒张压初始极大值点与舒张压阈值比较，剔除初始舒张压装置不满足条件的舒张压初始极大值点，更新后获得舒张压极值点；收缩压极值点获取装置700均与收缩压阈值装置500、初始收缩压装置300连接，用于将收缩压初始极小值点与收缩压阈值比较，剔除初始收缩压装置不满足条件的收缩压初始极小值点，更新后获得收缩压极值点。
如图3所示，本申请的一个实施例中，血压采集装置100包括：血压采集单元110和连接单元120，血压采集单元110与连接单元120可拆卸连接；血压采集单元110包括壳体111、血压传感器、信息传输结构和第一连接结构112，血压传感器、信息传输结构和第一连接结构112均设置于壳体111内，第一连接结构112与信息传输结构连接；连接单元120包括主体121、第二连接结构122和第三连接结构123，第二连接结构122与第三连接结构123均设置于主体121上，第二连接结构122与第一连接结构112可拆卸连接；第三连接结构123均与初始舒张压装置200、初始收缩压装置300连接。
本申请包括可拆卸连接的血压采集单元和连接单元，将一体式结构分成两部分，简化了安装工艺、 节省成本，便于零部件更换；且将壳体、血压传感器、信息传输结构和第一连接结构设置成一个整体，既实现了血压传感器端的采集和传输，又提高了血压传感器的密封性；将与外部设备连接的连接装置单独设置，减小了包装和运输体积，节省了成本，且安装容易。
本申请提供了一种计算机存储介质，计算机程序被处理器执行时实现上述的根据实时有创血压获取舒张压极值点和收缩压极值点的方法。
本发明的以上所述的具体实例，对本发明的目的、技术方案和有益效果进行了进一步详细说明，所应理解的是，以上所述仅为本发明的具体实施例而已，并不用于限制本发明，凡在本发明的精神和原则之内，所做的任何修改、等同替换、改进等，均应包含在本发明的保护范围之内。

Claims (11)

  1. 一种根据实时有创血压获取舒张压极值点和收缩压极值点的方法，其特征在于，包括：
    实时读取冠状动脉的有创血压；
    获得有创血压的最大值作为舒张压初始极大值点；
    获得有创血压的最小值作为收缩压初始极小值点；
    根据所述舒张压初始极大值点和所述收缩压初始极小值点分别获取舒张压阈值和收缩压阈值；
    将所述舒张压初始极大值点与所述舒张压阈值比较，剔除不满足条件的舒张压初始极大值点，更新后获得舒张压极值点；
    将所述收缩压初始极小值点与所述收缩压阈值比较，剔除不满足条件的收缩压初始极小值点，更新后获得收缩压极值点。
  2. 根据权利要求1所述的根据实时有创血压获取舒张压极值点和收缩压极值点的方法，其特征在于，所述获得有创血压的最大值作为舒张压初始极大值点的方法包括：
    如果P t0＞P t1＞P t2，则t 1时刻的有创血压P t1处于所述有创血压波形的下降趋势线上，将所有满足条件的所述下降趋势线上的有创血压值进行比较，获得有创血压的最大值作为舒张压初始极大值点；其中，P t1表示t 1时刻的有创血压，P t0表示与t 1相邻前一时刻t 0的有创血压，P t2表示与t 1相邻后一时刻t 2的有创血压。
  3. 根据权利要求1所述的根据实时有创血压获取舒张压极值点和收缩压极值点的方法，其特征在于，所述获得有创血压的最小值作为收缩压初始极小值点的方法包括：
    如果P t0＜P t1＜P t2，则t 1时刻的有创血压P t1处于所述有创血压波形的上升趋势线上，将所有满足条件的所述上升趋势线上的有创血压值进行比较，获得有创血压的最小值作为收缩压初始极小值点；其中，P t1表示t 1时刻的有创血压，P t0表示与t 1相邻前一时刻t 0的有创血压，P t2表示与t 1相邻后一时刻t 2的有创血压。
  4. 根据权利要求1所述的根据实时有创血压获取舒张压极值点和收缩压极值点的方法，其特征在于，所述根据所述舒张压初始极值点和所述收缩压初始极值点分别获取舒张压阈值和收缩压阈值的方法包括：
    P 舒张＝a P i+b P j；
    P 收缩＝b P i+a P j；
    a+b＝1；
    a＞0，b＞0；
    其中，a、b均表示常数，P 舒张表示舒张期阈值，P 收缩表示收缩期阈值，P i表示舒张压初始极大值点，P j表示收缩压初始极小值点。
  5. 根据权利要求4所述的根据实时有创血压获取舒张压极值点和收缩压极值点的方法，其特征在于，所述a的取值为1/8～1/2，b的取值为1/2～7/8。
  6. 根据权利要求5所述的根据实时有创血压获取舒张压极值点和收缩压极值点的方法，其特征在于，所述a＝1/4，b＝3/4。
  7. 根据权利要求2或3所述的根据实时有创血压获取舒张压极值点和收缩压极值点的方法，其特征 在于，在所述实时读取冠状动脉的有创血压之后，在所述获得有创血压的最大值作为舒张压初始极大值点之前，还包括：根据读取的有创血压值与时间生成时间域下的有创血压波形；
    如果P t1＜P t0，P t1＜P t2，则t 1时刻的有创血压P t1处于所述有创血压波形的波谷位置；
    如果P t0＜P t1＜P t2，则t 1时刻的有创血压P t1处于所述有创血压波形的上升趋势线上；
    如果P t0＞P t1＞P t2，则t 1时刻的有创血压P t1处于所述有创血压波形的下降趋势线上；
    如果P t1＞P t0，P t1＞P t2，则t 1时刻的有创血压P t1处于所述有创血压波形的波峰位置；
    根据所述有创血压波形的波峰、波谷，以及上升趋势线、下降趋势线，获得舒张压初始极大值点和收缩压初始极小值点。
  8. 一种获取冠状动脉血管评定参数的方法，其特征在于，包括：
    权利要求1～7任一项所述的根据实时有创血压获取舒张压极值点和收缩压极值点的方法；
    根据所述舒张压极值点和收缩压极值点获得血管评定参数，包括：平均压、平均动脉压。
  9. 一种根据实时有创血压获取舒张压极值点和收缩压极值点的系统，用于权利要求1～7任一项所述的根据实时有创血压获取舒张压极值点和收缩压极值点的方法，其特征在于，包括：血压采集装置、初始舒张压装置、初始收缩压装置、舒张压阈值装置、收缩压阈值装置、舒张压极值点获取装置和收缩压极值点获取装置；
    所述收缩压极值点获取装置均与所述收缩压阈值装置、所述初始收缩压装置连接，
    所述血压采集装置均与所述初始舒张压装置、所述初始收缩压装置连接，用于实时读取冠状动脉的有创血压；
    所述初始舒张压装置，用于根据所述血压采集装置获得的实时有创血压，经过比较，获得有创血压的最大值作为舒张压初始极大值点；
    所述初始收缩压装置，用于根据所述血压采集装置获得的实时有创血压，经过比较，获得有创血压的最小值作为收缩压初始极小值点；
    所述舒张压阈值装置均与所述初始舒张压装置、所述初始收缩压装置连接，用于根据所述舒张压初始极大值点和初始收缩压极小值点获取舒张压阈值；
    所述收缩压阈值装置均与所述初始舒张压装置、所述初始收缩压装置连接，用于根据所述舒张压初始极大值点和初始收缩压极小值点获取收缩压阈值；
    所述舒张压极值点获取装置均与所述舒张压阈值装置、所述初始舒张压装置连接，用于将所述舒张压初始极大值点与所述舒张压阈值比较，剔除所述初始舒张压装置不满足条件的舒张压初始极大值点，更新后获得舒张压极值点；
    所述收缩压极值点获取装置均与所述收缩压阈值装置、所述初始收缩压装置连接，用于将所述收缩压初始极小值点与所述收缩压阈值比较，剔除所述初始收缩压装置不满足条件的收缩压初始极小值点，更新后获得收缩压极值点。
  10. 根据权利要求9所述的根据实时有创血压获取舒张压极值点和收缩压极值点的系统，其特征在于，所述血压采集装置包括：血压采集单元和连接单元，所述血压采集单元与所述连接单元可拆卸连接；
    所述血压采集单元包括壳体、血压传感器、信息传输结构和第一连接结构，所述血压传感器、信息传输结构和第一连接结构均设置于所述壳体内，所述第一连接结构与所述信息传输结构连接；
    所述连接单元包括主体、第二连接结构和第三连接结构，所述第二连接结构与所述第三连接结构均设置于所述主体上，所述第二连接结构与所述第一连接结构可拆卸连接；
    所述第三连接结构均与所述初始舒张压装置、所述初始收缩压装置连接。
  11. 一种计算机存储介质，其特征在于，计算机程序被处理器执行时实现权利要求1～7任一项所述的根据实时有创血压获取舒张压极值点和收缩压极值点的方法。
PCT/CN2019/122911 2019-11-29 2019-12-04 根据有创血压获取舒张压、收缩压极值点的方法及系统 WO2021103067A1 (zh)

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