WO2021101169A2 - Phototherapy headset for alzheimer's disease patients - Google Patents

Phototherapy headset for alzheimer's disease patients Download PDF

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Publication number
WO2021101169A2
WO2021101169A2 PCT/KR2020/015907 KR2020015907W WO2021101169A2 WO 2021101169 A2 WO2021101169 A2 WO 2021101169A2 KR 2020015907 W KR2020015907 W KR 2020015907W WO 2021101169 A2 WO2021101169 A2 WO 2021101169A2
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alzheimer
phototherapy
headset
disease
lobe
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PCT/KR2020/015907
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French (fr)
Korean (ko)
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WO2021101169A3 (en
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윤영철
하동환
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중앙대학교 산학협력단
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M21/00—Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N5/0601—Apparatus for use inside the body
    • A61N5/0603—Apparatus for use inside the body for treatment of body cavities
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N5/0613—Apparatus adapted for a specific treatment
    • A61N5/0618—Psychological treatment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N5/0613—Apparatus adapted for a specific treatment
    • A61N5/0622—Optical stimulation for exciting neural tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M21/00—Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis
    • A61M2021/0005—Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis by the use of a particular sense, or stimulus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/05—General characteristics of the apparatus combined with other kinds of therapy
    • A61M2205/051—General characteristics of the apparatus combined with other kinds of therapy with radiation therapy
    • A61M2205/052—General characteristics of the apparatus combined with other kinds of therapy with radiation therapy infrared
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N2005/0635—Radiation therapy using light characterised by the body area to be irradiated
    • A61N2005/0643—Applicators, probes irradiating specific body areas in close proximity
    • A61N2005/0645—Applicators worn by the patient
    • A61N2005/0647—Applicators worn by the patient the applicator adapted to be worn on the head
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N2005/065—Light sources therefor
    • A61N2005/0651—Diodes
    • A61N2005/0652—Arrays of diodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N2005/0658—Radiation therapy using light characterised by the wavelength of light used
    • A61N2005/0659—Radiation therapy using light characterised by the wavelength of light used infrared

Definitions

  • the present invention relates to a phototherapy device, and more specifically, to a phototherapy headset for Alzheimer's disease patients, which enhances the Alzheimer's disease suppression and treatment effect by contrasting light through the inside of the nose to stimulate the medial temporal lobe.
  • AD Alzheimer's disease
  • amyloid plaques caused by accumulation of beta-amyloid in the brain and neurofibrillary tangles caused by hyperphosphorylated tau protein present in neurons.
  • the location of the initial lesion is the medial temporal area including the hippocampus, and then the lesion is enlarged to the parietal area.
  • the default mode network which is an area of the brain that becomes active when you are in a vague state or falls into a dream, is a network of neurons spread across the medial prefrontal cortex, posterior cortex, and parietal cortex, which is highly related to cognitive function. It is highly related to the pathology of Alzheimer's disease.
  • 1 is a distribution diagram of a default mode network and beta-amyloid plaques of Alzheimer's disease.
  • acetylcholinease inhibitor that inhibits the breakdown of acetylcholine in the nerve junction, which is a symptom-improving drug that improves cognitive function.
  • near infrared is used in various diagnostic medical devices because it can transmit several centimeters with photons of 700-1100 nm.
  • One of them is a pulse oximeter. It is also used as transcranial cerebral oximetry through bones.
  • Alzheimer's disease shows abnormalities in the hippocampus and the medial temporal lobe and parietal lobe, which are surrounding areas, from the beginning, causing symptoms of Alzheimer's disease dementia.
  • the medial parietal area and frontal lobe which are part of the default mode network related to cognitive function, are also major pathologies of Alzheimer's disease.
  • the present invention is to solve the problems of the prior art Alzheimer's disease suppression and treatment techniques, phototherapy for patients with Alzheimer's disease that enhances Alzheimer's disease suppression and treatment effects by allowing light to be irradiated through the inside of the nose to stimulate the medial temporal lobe Its purpose is to provide a headset.
  • the present invention is a phototherapy for Alzheimer's disease patients in which light is focused through the inside of the nose and the stimulation site of the LED is changed to the upper part to effectively stimulate the medial temporal lobe and parietal lobe including the hippocampus, which is the main location of the pathology of Alzheimer's disease. Its purpose is to provide a headset.
  • the present invention provides a medial temporal lobe including the hippocampus through a nasal probe located in the nasal cavity having an infrared (810nm) LED capable of gamma (40Hz) and alpha (10Hz) flicker.
  • the purpose of this study is to provide a phototherapy headset for Alzheimer's disease patients that can effectively stimulate the temporal lobe.
  • the present invention stimulates the dorsolateral parietal lobe by moving the stimulation position upward from the dorsolateral temporal lobe stimulation position, and stimulates the medial frontal lobe and the inner parietal lobe.
  • the purpose of this is to provide a phototherapy headset for Alzheimer's disease patients with improved Alzheimer's suppression and treatment effects by providing maximum access to the Papez's circuit involved in the memory production process.
  • the present invention is a patient with Alzheimer's disease that selects the location of the cerebrum of the photostimulation and adjusts the frequency of the blinking stimulus of infrared rays by reflecting the brain waves of individual patients, thereby effectively performing phototherapy for Alzheimer's disease treatment. Its purpose is to provide a phototherapy headset for the patient.
  • a plurality of irradiation means such as LEDs are provided to enable selection of the irradiation angle, irradiation intensity, and flicker degree in each region of the regions in which each stimulation means is located inside the headset of the helmet structure, so that it is precisely at the position where stimulation is required. It is an object of the present invention to provide a phototherapy headset for Alzheimer's disease patients that enables effective phototherapy (photic modulation).
  • the phototherapy headset for a patient with Alzheimer's disease for achieving the above object includes optical stimulation means for selectively inducing synchronized gamma vibration and alpha vibration in at least one brain region of an individual, and the light
  • the stimulation means comprise an intranasal infrared LED probe to be placed in the nasal cavity to stimulate the medial temporal lobe including the hippocampus.
  • the light stimulation means characterized in that it comprises a light stimulation means each configured at a position for stimulating a dorsolateral parietal lobe, a frontal lobe, or a medial parietal lobe.
  • the intranasal infrared LED probe has an irradiation intensity of ⁇ 80mW, and is configured at a position to stimulate the dorsolateral parietal lobe, the frontal lobe, or the medial parietal lobe.
  • the light stimulation means are characterized by having an irradiation intensity of ⁇ 100mW.
  • the optical stimulation means includes an infrared (810nm) LED that can be switched to blinking of gamma and alpha frequencies, and the blinking of a gamma wave by the wavelength adjusting means is an alpha wave within 30-40Hz.
  • Flicker is characterized in that it is controlled in the range of 8-12Hz.
  • the phototherapy headset for patients with Alzheimer's disease for achieving another object is gamma and gamma to increase the vibration of the reduced gamma wave and alpha wave obtained from quantitative brain waves of Alzheimer's disease patients.
  • a phototherapy control unit that controls to provide the flicker of the alpha frequency; a therapeutic light irradiator that irradiates light to irradiate the target site for phototherapy under the control of the phototherapy controller; a wavelength that controls the flicker of gamma and alpha frequencies within a certain range It characterized in that it comprises a; control means; light stimulation means for irradiating the flicker of the gamma and alpha frequency of the range adjusted by the wavelength control means to the target site selected by the control of the phototherapy control unit; and characterized in that it comprises a.
  • the light stimulation means is an intranasal infrared LED probe to be located in the nasal cavity so as to stimulate the medial temporal lobe including the hippocampus, the dorsolateral parietal lobe or the frontal lobe, or It characterized in that it comprises light stimulation means each configured at a position to stimulate the medial parietal lobe.
  • 10 in the power spectrum of gamma and alpha waves obtained by quantitative EEG of Alzheimer's disease patients with reduced oscillations of gamma and alpha waves. It is characterized in that the vibration (oscillation) is recovered by stimulating by controlling the flicker of the LED of the light stimulation means in the range of -20% increase.
  • the phototherapy headset has a helmet shape that can wrap the head inward, and is used to stimulate the dorsolateral parietal lobe, the frontal lobe, and the medial parietal lobe, etc.
  • Light stimulation means and power supply means are provided, and an intranasal infrared LED probe for stimulating a medial temporal lobe is connected to the headset body.
  • the light stimulation means is a plurality of LEDs having different irradiation directions and irradiation intensity in each area are arranged in one row or multiple rows, and a specific number or a specific position of LEDs is selected from among a plurality of arranged LEDs to direct light to the target area. It is characterized in that to investigate.
  • the light stimulation means has a plurality of LEDs in each area, and analyzes the image data acquired during the diagnosis process for Alzheimer's disease suppression and treatment in order to select a specific number or specific location of the LEDs to determine the shape and size of the patient's head. , It is characterized in that a specific number or LEDs of a specific location are selected based on this by extracting location information requiring stimulation.
  • the phototherapy headset for Alzheimer's disease patients according to the present invention as described above has the following effects.
  • the light is contrasted through the inside of the nose, and the stimulation site of the LED is changed to the upper part, so that the medial temporal lobe and parietal lobe including the hippocampus, which are the major locations of Alzheimer's disease, can be effectively stimulated.
  • the default mode network and memory It increases the effectiveness of Alzheimer's disease suppression and treatment by maximizing access to Papez's circuit, which is involved in the production process.
  • the location of the cerebrum of the photostimulation is selected, and the frequency of the blinking stimulus of infrared rays is adjusted by reflecting the brain waves of individual patients, so that the phototherapy (photic modulation) for the treatment of Alzheimer's disease can be effectively performed.
  • a plurality of irradiation means such as LEDs are provided to select the irradiation angle, irradiation intensity, and degree of flicker in each area of the areas where each stimulation means is located inside the headset of the helmet structure, so that phototherapy is precisely where stimulation is required. (photic modulation) can be effectively performed.
  • 1 is a distribution diagram of a default mode network and beta-amyloid plaques of Alzheimer's disease
  • FIGS. 2A and 2B are configuration diagrams showing a target site during phototherapy using a phototherapy headset for a patient with Alzheimer's disease according to the present invention.
  • FIG. 3 is an outer and inner configuration diagram of a phototherapy headset for a patient with Alzheimer's disease according to the present invention
  • FIG. 4 is a circuit diagram of a phototherapy headset for a patient with Alzheimer's disease according to the present invention
  • FIGS. 2A and 2B are diagrams showing a target site during phototherapy using a phototherapy headset for a patient with Alzheimer's disease according to the present invention.
  • the phototherapy headset for patients with Alzheimer's disease is a nasal probe located in the nasal cavity having an infrared (810 nm) LED capable of gamma (40 Hz) and alpha (10 Hz) flicker.
  • the medial temporal lobe, including the hippocampus, can be effectively stimulated.
  • the default mode network and memory It has a structure that can increase Alzheimer's disease suppression and treatment effects by making it as close as possible to the Papez's circuit, which is involved in the production process.
  • the present invention may include a configuration in which a position of the cerebrum of the photostimulation is selected, and the frequency of the blinking stimulus of infrared rays is adjusted by reflecting an EEG of an individual patient.
  • a plurality of light stimulation means such as LEDs are provided to enable selection of the irradiation angle, irradiation intensity, and degree of flicker in each of the areas in which each stimulation means is located inside the headset of the helmet structure, so that it is precisely at the position where stimulation is required It may include a configuration to effectively perform phototherapy (photic modulation).
  • the light stimulation means may be arranged in a row or multiple rows of LEDs with different irradiation directions in each area, and accurately target light by selecting a specific number or LEDs at a specific location from among a plurality of LEDs arranged in this way.
  • the phototherapy effect can be enhanced by irradiating the area.
  • the present invention may include the following configuration to select a specific number or a specific location of the LEDs.
  • image data acquired during a diagnosis process for suppression and treatment of Alzheimer's disease are analyzed to extract the shape of the patient's head, the size of the head, and location information that requires stimulation, and arrange it inside the headset of the helmet structure based on this. It is to select a specific number or a specific location of the LEDs among the plurality of LEDs.
  • analyzing the image data to extract the patient's head shape, head size, and location information requiring stimulation is a widely used technique, and a detailed description thereof will be omitted.
  • the present invention in order to effectively stimulate the medial temporal lobe and parietal lobe including the hippocampus, which are the major locations of the pathology of Alzheimer's disease, the present invention is different from stimulating the lateral temporal lobe or the occipital area.
  • the stimulation part of the LED is placed at the top.
  • a nasal probe to be placed in the nasal cavity was prepared to stimulate the medial temporal lobe including the hippocampus with infrared (810nm) LEDs capable of flickering gamma (40Hz) and alpha (10Hz).
  • the dorsolateral parietal lobe it moved upward from the dorsolateral temporal lobe stimulation position.
  • the default mode network and Papez's circuit which is involved in the process of memory generation, can be approached as much as possible, thereby improving the effectiveness of Alzheimer's disease suppression and treatment. Have.
  • FIG. 3 is an outer and inner configuration diagram of a phototherapy headset for a patient with Alzheimer's disease according to the present invention.
  • a probe was made through the nose and LEDs to stimulate both parietal lobes, frontal and parietal lobes were placed to stimulate the pathology of Alzheimer's disease more than conventional lateral temporal lobe stimulation and visual stimulation. Target location and allow you to control functions.
  • the main gamma waves and alpha waves obtained by quantitative EEG of individual patients In the range of 10-20% increase in the power spectrum, it is possible to restore the oscillation by controlling the flicker of the LED and stimulating it.
  • the headset according to the present invention has a helmet shape that can be positioned and wrapped around the head as shown in FIG. 3, and the dorsolateral parietal lobe, the frontal lobe, and the medial parietal lobe ( Medial parietal lobe), light stimulation means (120a) (120b) (120c) (120d) for stimulating, etc. are provided, and an intranasal infrared LED probe 110 for stimulating the medial temporal lobe is a headset It is configured by being connected to the main body 100.
  • the light stimulation means (120a) (120b) (120c, 120d) may be arranged in one row or multiple rows of LEDs having different irradiation directions in each installation area, among a plurality of LEDs arranged in this way. It is configured so that it is possible to accurately irradiate light onto a target site by selecting a specific number or a specific location of LEDs.
  • the present invention analyzes the image data acquired during the diagnosis process for Alzheimer's disease suppression and treatment, extracts the patient's head shape, head size, and location information that requires stimulation, and is based on this. It is possible to select and control the optical stimulation means.
  • the phototherapy headset for a patient with Alzheimer's disease having such a structure selects the position of the optical stimulation means in consideration of the location of the pathology in the brain of Alzheimer's disease and the default mode network, and quantitative EEG of the Alzheimer's disease patient.
  • Photic modulation headset to provide increased gamma and alpha frequency flicker in the range of 10-20% to increase the vibration of the reduced gamma wave and alpha wave obtained in ).
  • Infrared light which flickers at 40Hz, can affect the metabolism of beta-amyloid, a major cause of Alzheimer's disease.
  • the use of the phototherapy headset for Alzheimer's disease patients according to the present invention can be expected to improve the pathologic mechanism and cognitive function of Alzheimer's disease.
  • a detailed circuit configuration of a phototherapy headset for a patient with Alzheimer's disease according to the present invention will be described as follows.
  • FIG. 4 is a circuit diagram of a phototherapy headset for a patient with Alzheimer's disease according to the present invention.
  • the phototherapy headset for patients with Alzheimer's disease provides flickering of gamma and alpha frequencies to increase the vibration of reduced gamma waves and alpha waves obtained from quantitative brain waves of Alzheimer's patients.
  • the phototherapy control unit 40 for controlling the light treatment the therapeutic light irradiation unit 41 for irradiating light to irradiate the target site for phototherapy under the control of the phototherapy control unit 40, and the blinking schedule of gamma and alpha frequencies.
  • the medial temporal lobe stimulation part 44 is an intranasal infrared LED probe for stimulating a medial temporal lobe.
  • the light stimulation means are lateral parietal lobe stimulation (45), lateral frontal lobe stimulation (46), medial parietal lobe stimulation to stimulate the dorsolateral parietal lobe, frontal lobe, and medial parietal lobe. Includes part 47.
  • the phototherapy headset for a patient with Alzheimer's disease has a built-in power supply unit 42 for a light source for irradiating treatment light to increase user convenience.
  • the phototherapy control unit 40 may track a trend in the degree of improvement of the patient's condition using data on changes in brain waves and use time of the patient to perform phototherapy control in a direction that can increase the treatment effect.
  • the phototherapy headset for patients with Alzheimer's disease includes an infrared (810nm) LED that can be switched to blinking of gamma and alpha frequencies.
  • the flicker of the gamma wave can be controlled within 30-40Hz by the wavelength control means 43 and the flicker of the alpha wave can be controlled in the range of 8-12Hz.
  • the intranasal infrared LED probe to be located in the nasal cavity to stimulate the medial temporal lobe including the hippocampus has an irradiation intensity of ⁇ 80mW, and the dorsolateral parietal lobe and frontal lobe It is preferable that the light stimulation means for stimulating the medial parietal lobe have an irradiation intensity of ⁇ 100mW.
  • the phototherapy headset for patients with Alzheimer's disease selects the cerebral position of the photostimulation based on the theoretical background and concept of the pathologic mechanism of Alzheimer's disease, and reflects the brain waves of individual patients, and the frequency of the flickering stimulation of infrared rays. By controlling, it is possible to effectively perform photic modulation for Alzheimer's disease treatment.
  • the phototherapy headset for Alzheimer's disease patients according to the present invention described above is a nasal probe located in the nasal cavity having an infrared (810nm) LED capable of gamma (40Hz) and alpha (10Hz) flickering (The medial temporal lobe including the hippocampus can be effectively stimulated through a nasal probe.
  • the present invention relates to a phototherapy device, and more specifically, to a phototherapy headset for Alzheimer's disease patients, which enhances the Alzheimer's disease suppression and treatment effect by contrasting light through the inside of the nose to stimulate the medial temporal lobe.

Abstract

The present invention relates to a phototherapy headset for Alzheimer's disease patients, which irradiates light via the inside of a nose to enable the medial temporal lobe to be stimulated, thereby enhancing the effect of inhibiting and treating Alzheimer's disease. The headset is provided with photic stimulation means for selectively inducing synchronous gamma oscillations and alpha oscillations in at least one brain region of an individual, wherein the photic stimulation means comprise an intranasal infrared LED probe that is to be positioned in the nasal cavity to stimulate the medial temporal lobe, including the hippocampus.

Description

알츠하이머병 환자를 위한 광치료 헤드셋Phototherapy headset for Alzheimer's patients
본 발명은 광치료 장치에 관한 것으로, 구체적으로 코 내부를 통해 빛을 조영하여 내측 측두엽을 자극할 수 있도록 하여 알츠하이머병 억제 및 치료 효과를 높인 알츠하이머병 환자를 위한 광치료 헤드셋에 관한 것이다.The present invention relates to a phototherapy device, and more specifically, to a phototherapy headset for Alzheimer's disease patients, which enhances the Alzheimer's disease suppression and treatment effect by contrasting light through the inside of the nose to stimulate the medial temporal lobe.
알츠하이머병(Alzheimer’s disease; AD)은 신경세포의 퇴행성변화로 기억력을 포함한 인지기능의 장애로 나타난다.Alzheimer's disease (AD) is a degenerative change in nerve cells that appears as a disorder of cognitive function, including memory.
그 중요한 병리소견은 뇌에 베타-아밀로이드(beta-amyloid)의 축적에 의한 아밀로이드 플라그(amyloid plaque)와 신경세포내에 존재하는 과인산화된 타우(tau) 단백에 의한 신경섬유다발(neurofibrillary tangle)이다.The important pathologic findings are amyloid plaques caused by accumulation of beta-amyloid in the brain and neurofibrillary tangles caused by hyperphosphorylated tau protein present in neurons.
초기 병변의 위치는 해마(hippocampus)를 포함한 내측 측두엽(medial temporal area)이며, 이후 두정엽부위(parietal area)로 병변이 확대된다.The location of the initial lesion is the medial temporal area including the hippocampus, and then the lesion is enlarged to the parietal area.
멍한 상태이거나 몽상에 빠졌을 때 활발해지는 뇌의 영역으로 내측전전두엽피질, 후대상피질, 두정엽피질에 퍼져 있는 신경세포망에 해당하는 디폴트 모드 네트워크(Default mode network)는 인지기능과 매우 관련이 높은 영역으로 알츠하이머병의 병리와 상당히 관련이 높다.The default mode network, which is an area of the brain that becomes active when you are in a vague state or falls into a dream, is a network of neurons spread across the medial prefrontal cortex, posterior cortex, and parietal cortex, which is highly related to cognitive function. It is highly related to the pathology of Alzheimer's disease.
도 1은 디폴트 모드 네트워크(Default mode network)와 알츠하이머병의 베타-아밀로이드 플라그의 분포도이다.1 is a distribution diagram of a default mode network and beta-amyloid plaques of Alzheimer's disease.
디폴트 모드 네트워크(Default mode network)와 알츠하이머병의 베타-아밀로이드 플라그의 분포와 뇌 위축 양상의 일치를 확인할 수 있다.It is possible to confirm the agreement between the distribution of the beta-amyloid plaque of Alzheimer's disease and the brain atrophy pattern with the default mode network.
현재 알츠하이머병의 병리를 변경시키는 치료법은 없는 상태이며, 현재 치료는 신경연접(synapse)내에 아세틸콜린(acetylcholine)의 분해를 억제하는 아세틸콜린분해효소억제제이며, 이는 인지기능을 개선시키는 증상 개선약물이다.Currently, there is no cure for altering the pathology of Alzheimer's disease, and the current treatment is an acetylcholinease inhibitor that inhibits the breakdown of acetylcholine in the nerve junction, which is a symptom-improving drug that improves cognitive function. .
하지만, 병의 경과를 바꾸기 위한 약물로 대뇌에 축척된 베타-아밀로이드(beta-amyloid)를 제거하는 기술은 개발이 진행 중이지만, 아직 성과가 없는 상태이다.However, a technology for removing beta-amyloid accumulated in the cerebrum as a drug to change the course of the disease is under development, but has not yet been achieved.
한편, 알츠하이머병에서 빛을 이용한 치료가 또 다른 옵션으로 최근에 관심을 받고 있다.(1. Impact of Photobiomodulation (PBM) on Biomarkers of Alzheimer’s Disease. University of California, San Francisco University of Brisbane (Australian New Zealand Clinical Trials Registry). 2. Evaluation of dose of Photobiomodulation (Light) Therapy and Physiotherapy for Improving Quality of Life Outcomes and Mobility in Parkinson’s Disease (Pilot) University of Sydney, (clinicaltrials.gov, U.S. National Institutes of Health))On the other hand, treatment with light in Alzheimer's disease has recently attracted attention as another option (1.Impact of Photobiomodulation (PBM) on Biomarkers of Alzheimer's Disease.University of California, San Francisco University of Brisbane (Australian New Zealand Clinical). Trials Registry).2.Evaluation of dose of Photobiomodulation (Light) Therapy and Physiotherapy for Improving Quality of Life Outcomes and Mobility in Parkinson's Disease (Pilot) University of Sydney, (clinicaltrials.gov, US National Institutes of Health))
그 중 적외선(near infrared)은 700-1100nm의 광자로 수 cm를 투과할 수 있어 여러 진단용 의료기기에 사용되고 있다.Among them, near infrared is used in various diagnostic medical devices because it can transmit several centimeters with photons of 700-1100 nm.
그 중에 대표적인 것이 펄스 옥시미터(pulse oximeter)이다. 뼈도 통과하여 경두개 셀러브럴 옥시메트리(transcranial cerebral oximetry)로도 사용되고 있다. One of them is a pulse oximeter. It is also used as transcranial cerebral oximetry through bones.
2015년 Li-Huei 연구에 의하면, 매일 1시간씩 깜박이는 빛에 노출시킨 알츠하이머병 모델 쥐의 뇌에 이 병의 원인인 베타-아밀로이드(beta-amyloid)에 의해 생성된 플라그(plaque)의 농도가 현저하게 저하되었다.According to a 2015 Li-Huei study, the concentration of plaque produced by beta-amyloid, which is the cause of the disease, in the brains of Alzheimer's disease model mice exposed to blinking light for 1 hour every day. Markedly deteriorated.
MIT의 신경과학자인 Tsai 등은 이때 깜박이는 빛은 40Hz일 때가 효과적이었다고 하였다. 1주일간 매일 1시간씩 노출시킨 경우에도 시각피질(visual cortex)에 국한되어, 아밀로이드 플라그(amyloid plaque)가 67% 감소하였고 타우 단백질(tau protein)도 감소하였다.Tsai et al., a neuroscientist at MIT, said that the blinking light was effective at 40Hz. Even when exposed for 1 hour every day for 1 week, it was confined to the visual cortex, resulting in a 67% decrease in amyloid plaque and a decrease in tau protein.
알츠하이머병 환자는 뇌파의 감마(gamma)(25 and 100 Hz이며, 40Hz가 전형적인 파)와 알파(alpha)( 8-12 Hz) oscillations이 감소되어 있어, 감마(gamma)와 알파 진동(alpha oscillation)을 회복시켜 줄 수 있다면, 이 질환에 기능적인 측면에서도 효과가 있을 것이다.In patients with Alzheimer's disease, gamma (25 and 100 Hz, 40 Hz is a typical wave) and alpha (8-12 Hz) oscillations of EEG are reduced, resulting in gamma and alpha oscillation. If you can restore the disease, it will also have a functional effect on this disease.
실제로 Tsai 등의 연구에 의하면, 이러한 감마 진동(gamma oscillation)이 미세아교세포(microglial cell)의 유전자 발현(gene expression)을 변화시켜 청소부역할(scavenger mode)을 할 수 있도록 변하게 하였다.In fact, according to the research of Tsai et al., such gamma oscillation changed the gene expression of microglial cells to be able to play a scavenger mode.
이러한 변화는 뇌의 베타-아밀로이드 플라그(beta-amyloid plaque)를 제거하는 데 도움이 될 수 있다.These changes can help remove beta-amyloid plaques from the brain.
이와 같이 알츠하이머병은 해마와 그 주변 부위인 내측 측두엽과, 두정엽에 초기부터 이상을 보이며, 이로 인해 알츠하이머병 치매의 증상을 일으킨다.As such, Alzheimer's disease shows abnormalities in the hippocampus and the medial temporal lobe and parietal lobe, which are surrounding areas, from the beginning, causing symptoms of Alzheimer's disease dementia.
또한 최근에는 인지기능과 관련이 있는 디폴트 모드 네트워크(default mode network)의 일부인 내측 두정엽부위(medial parietal area)과 전두엽도 알츠하이머병의 주요 병리부위이다. In addition, recently, the medial parietal area and frontal lobe, which are part of the default mode network related to cognitive function, are also major pathologies of Alzheimer's disease.
그러나 기존 연구에서 Tsai등은 더 가까운 측두엽(temporal lobe)을 자극하기 위해 소리자극을 주기도 하였다. 소리자극에 의한 델타 진동(delta oscillation)은 수면 중에 자극하여 기억 공고화(memory consolidation)에 도움을 준다고 보고하였다.However, in previous studies, Tsai et al. gave sound stimulation to stimulate the closer temporal lobe. It has been reported that delta oscillation caused by sound stimulation is stimulated during sleep and helps in memory consolidation.
하지만 이 역시, 외측 측두엽(dorosolateral temporal area)에 자극이 집중되어, 알츠하이머병의 표적병리(target pathology)인 내측 측두엽(medial temporal area)과는 거리가 있다.However, this too, because the stimulus is concentrated in the dorosolateral temporal area, it is far from the medial temporal area, which is the target pathology of Alzheimer's disease.
이상에서와 같이 종래 기술의 알츠하이머병 억제 및 치료에 관한 기술들은 자극 효과를 높이기 위한 자극 부위 제어, 자극 수단, 자극 방법들의 고도화에 한계가 있어 극히 제한적인 효과들을 구현하는 문제가 있다.As described above, techniques related to Alzheimer's disease suppression and treatment of the prior art have limitations in the advancement of stimulation site control, stimulation means, and stimulation methods for increasing stimulation effects, thereby implementing extremely limited effects.
따라서, 내측 측두엽을 자극할 수 있도록 하여 알츠하이머병 억제 및 치료 효과를 높일 수 있도록 하는 새로운 기술의 개발이 요구되고 있다.Therefore, there is a need for the development of a new technology that can stimulate the medial temporal lobe to increase the Alzheimer's disease suppression and treatment effect.
본 발명은 종래 기술의 알츠하이머병 억제 및 치료 기술들의 문제점을 해결하기 위한 것으로, 코 내부를 통해 빛을 조영하여 내측 측두엽을 자극할 수 있도록 하여 알츠하이머병 억제 및 치료 효과를 높인 알츠하이머병 환자를 위한 광치료 헤드셋을 제공하는데 그 목적이 있다.The present invention is to solve the problems of the prior art Alzheimer's disease suppression and treatment techniques, phototherapy for patients with Alzheimer's disease that enhances Alzheimer's disease suppression and treatment effects by allowing light to be irradiated through the inside of the nose to stimulate the medial temporal lobe Its purpose is to provide a headset.
본 발명은 코 내부를 통해 빛을 조영하고, LED의 자극부위를 상부로 변경하여 알츠하이머병의 병리의 주요 위치인 해마가 포함된 내측 측두엽과 두정엽을 효과적으로 자극할 수 있도록 한 알츠하이머병 환자를 위한 광치료 헤드셋을 제공하는데 그 목적이 있다.The present invention is a phototherapy for Alzheimer's disease patients in which light is focused through the inside of the nose and the stimulation site of the LED is changed to the upper part to effectively stimulate the medial temporal lobe and parietal lobe including the hippocampus, which is the main location of the pathology of Alzheimer's disease. Its purpose is to provide a headset.
본 발명은 감마(gamma)(40Hz)와 알파(alpha)(10Hz) 깜빡임이 가능한 적외선 (810nm) LED를 갖는 비강(鼻腔)내에 위치하는 비강 프로브(nasal probe)를 통하여 해마를 포함한 내측 측두엽(medial temporal lobe)을 효과적으로 자극할 수 있도록 한 알츠하이머병 환자를 위한 광치료 헤드셋을 제공하는데 그 목적이 있다.The present invention provides a medial temporal lobe including the hippocampus through a nasal probe located in the nasal cavity having an infrared (810nm) LED capable of gamma (40Hz) and alpha (10Hz) flicker. The purpose of this study is to provide a phototherapy headset for Alzheimer's disease patients that can effectively stimulate the temporal lobe.
본 발명은 외측 측두엽(dorsolateral temporal lobe) 자극 위치에서 상방향으로 자극 위치를 이동하여 외측 두정엽(dorsolateral parietal lobe)을 자극하고, 전두엽내측과 두정엽 내측을 자극하여, 디폴트 모드 네트워크(default mode network)와 기억생성과정에 관여하는 파페즈 회로(Papez’s circuit)에 최대한 접근하도록 하여 알츠하이머병 억제 및 치료 효과를 높인 알츠하이머병 환자를 위한 광치료 헤드셋을 제공하는데 그 목적이 있다.The present invention stimulates the dorsolateral parietal lobe by moving the stimulation position upward from the dorsolateral temporal lobe stimulation position, and stimulates the medial frontal lobe and the inner parietal lobe. The purpose of this is to provide a phototherapy headset for Alzheimer's disease patients with improved Alzheimer's suppression and treatment effects by providing maximum access to the Papez's circuit involved in the memory production process.
본 발명은 광자극의 대뇌의 위치를 선정하고, 개별 환자의 뇌파를 반영하여 적외선의 깜빡임 자극의 빈도를 조절하여, 알츠하이머병 치료를 위한 광치료(photic modulation)를 효과적으로 수행할 수 있도록 하는 알츠하이머병 환자를 위한 광치료 헤드셋을 제공하는데 그 목적이 있다.The present invention is a patient with Alzheimer's disease that selects the location of the cerebrum of the photostimulation and adjusts the frequency of the blinking stimulus of infrared rays by reflecting the brain waves of individual patients, thereby effectively performing phototherapy for Alzheimer's disease treatment. Its purpose is to provide a phototherapy headset for the patient.
본 발명은 헬멧 구조의 헤드셋 내부에 각각의 자극 수단이 위치하는 영역들의 각 영역에 조사 각도, 조사 세기, 깜박임 정도의 선택이 가능하도록 LED 등의 조사 수단들이 복수개 구비되어 자극이 필요한 위치에 정밀하게 광치료(photic modulation)를 효과적으로 수행할 수 있도록 하는 알츠하이머병 환자를 위한 광치료 헤드셋을 제공하는데 그 목적이 있다.In the present invention, a plurality of irradiation means such as LEDs are provided to enable selection of the irradiation angle, irradiation intensity, and flicker degree in each region of the regions in which each stimulation means is located inside the headset of the helmet structure, so that it is precisely at the position where stimulation is required. It is an object of the present invention to provide a phototherapy headset for Alzheimer's disease patients that enables effective phototherapy (photic modulation).
본 발명의 다른 목적들은 이상에서 언급한 목적으로 제한되지 않으며, 언급되지 않은 또 다른 목적들은 아래의 기재로부터 당업자에게 명확하게 이해될 수 있을 것이다.Other objects of the present invention are not limited to the above-mentioned objects, and other objects not mentioned will be clearly understood by those skilled in the art from the following description.
상기와 같은 목적을 달성하기 위한 본 발명에 따른 알츠하이머병 환자를 위한 광치료 헤드셋은 개체의 최소한 하나의 뇌 영역에서 동기화된 감마 진동과 알파 진동을 선택적으로 유도하기 위한 광 자극 수단들을 구비하고, 상기 광 자극 수단들은 해마를 포함한 내측 측두엽(medial temporal lobe)을 자극할 수 있도록 비강(鼻腔)내에 위치할 비강내 적외선 LED 프로브를 포함하는 것을 특징으로 한다.The phototherapy headset for a patient with Alzheimer's disease according to the present invention for achieving the above object includes optical stimulation means for selectively inducing synchronized gamma vibration and alpha vibration in at least one brain region of an individual, and the light The stimulation means comprise an intranasal infrared LED probe to be placed in the nasal cavity to stimulate the medial temporal lobe including the hippocampus.
여기서, 상기 광 자극 수단들은, 외측 두정엽(dorsolateral parietal lobe) 또는 전두엽 (frontal lobe) 또는 내측 두정엽(medial parietal lobe)을 자극하는 위치에 각각 구성되는 광 자극 수단들을 포함하는 것을 특징으로 한다.Here, the light stimulation means, characterized in that it comprises a light stimulation means each configured at a position for stimulating a dorsolateral parietal lobe, a frontal lobe, or a medial parietal lobe.
그리고 상기 광 자극 수단들 중에서 비강내 적외선 LED 프로브는 ~80mW의 조사 세기를 갖고, 외측 두정엽(dorsolateral parietal lobe) 또는 전두엽 (frontal lobe) 또는 내측 두정엽(medial parietal lobe)을 자극하는 위치에 각각 구성되는 광 자극 수단들은 ~100mW의 조사 세기를 갖는 것을 특징으로 한다.And among the light stimulation means, the intranasal infrared LED probe has an irradiation intensity of ~80mW, and is configured at a position to stimulate the dorsolateral parietal lobe, the frontal lobe, or the medial parietal lobe. The light stimulation means are characterized by having an irradiation intensity of ~100mW.
그리고 상기 광 자극 수단들은, 감마와 알파 주파수의 깜빡임으로 전환이 가능한 적외선(810nm) LED를 구비하고, 파장 조절 수단에 의해 감마 파(gamma wave)의 깜빡임은 30-40Hz내에서 알파 파(alpha wave)의 깜빡임은 8-12Hz 범위에서 조절하는 것을 특징으로 한다.In addition, the optical stimulation means includes an infrared (810nm) LED that can be switched to blinking of gamma and alpha frequencies, and the blinking of a gamma wave by the wavelength adjusting means is an alpha wave within 30-40Hz. ) Flicker is characterized in that it is controlled in the range of 8-12Hz.
다른 목적을 달성하기 위한 본 발명에 따른 알츠하이머병 환자를 위한 광치료 헤드셋은 알츠하이머병 환자의 정량뇌파에서 얻어진 감소된 감마 파(gamma wave)와 알파 파(alpha wave)의 진동을 증가시킬 수 있도록 감마와 알파 주파수의 깜빡임을 제공하기 위한 제어를 하는 광치료 제어부;광치료 제어부의 제어에 의해 광치료를 위하여 표적 부위에 조사하기 위한 빛을 조사하는 치료광 조사부;감마와 알파 주파수의 깜빡임을 일정 범위에서 조절하는 파장 조절 수단;파장 조절 수단에 의해 조절된 범위의 감마와 알파 주파수의 깜빡임을 광치료 제어부의 제어에 의해 선택된 표적 부위에 조사하는 광 자극 수단들;을 포함하는 것을 특징으로 한다.The phototherapy headset for patients with Alzheimer's disease according to the present invention for achieving another object is gamma and gamma to increase the vibration of the reduced gamma wave and alpha wave obtained from quantitative brain waves of Alzheimer's disease patients. A phototherapy control unit that controls to provide the flicker of the alpha frequency; a therapeutic light irradiator that irradiates light to irradiate the target site for phototherapy under the control of the phototherapy controller; a wavelength that controls the flicker of gamma and alpha frequencies within a certain range It characterized in that it comprises a; control means; light stimulation means for irradiating the flicker of the gamma and alpha frequency of the range adjusted by the wavelength control means to the target site selected by the control of the phototherapy control unit; and characterized in that it comprises a.
여기서, 광 자극 수단들은, 해마를 포함한 내측 측두엽(medial temporal lobe)을 자극할 수 있도록 비강(鼻腔)내에 위치할 비강내 적외선 LED 프로브와, 외측 두정엽(dorsolateral parietal lobe) 또는 전두엽 (frontal lobe) 또는 내측 두정엽(medial parietal lobe)을 자극하는 위치에 각각 구성되는 광 자극 수단들을 포함하는 것을 특징으로 한다.Here, the light stimulation means is an intranasal infrared LED probe to be located in the nasal cavity so as to stimulate the medial temporal lobe including the hippocampus, the dorsolateral parietal lobe or the frontal lobe, or It characterized in that it comprises light stimulation means each configured at a position to stimulate the medial parietal lobe.
그리고 감마 파(gamma wave)와 알파 파(alpha wave)의 진동(oscillations)이 감소되어 있는 알츠하이머병 환자의 정량뇌파측정(quantitative EEG)으로 얻어진, 감마 파와 알파 파의 파워 스펙트럼(power spectrum)에서 10-20% 증가된 범위에서 광 자극 수단의 LED의 깜빡임을 조절하여 자극하여 진동(oscillation)이 회복되도록 하는 것을 특징으로 한다.In addition, 10 in the power spectrum of gamma and alpha waves obtained by quantitative EEG of Alzheimer's disease patients with reduced oscillations of gamma and alpha waves. It is characterized in that the vibration (oscillation) is recovered by stimulating by controlling the flicker of the LED of the light stimulation means in the range of -20% increase.
그리고 광치료 헤드셋은, 두부를 내측으로 위치시켜 감쌀 수 있는 헬멧 형태를 갖고, 헤드셋 본체의 내부에 외측 두정엽(dorsolateral parietal lobe)과 전두엽(frontal lobe)과 내측 두정엽(medial parietal lobe) 등을 자극하기 위한 광 자극 수단들 및 전원 공급 수단이 구비되고, 내측 측두엽(medial temporal lobe)을 자극하기 위한 비강내 적외선 LED 프로브가 헤드셋 본체에 연결되어 구성되는 것을 특징으로 한다.In addition, the phototherapy headset has a helmet shape that can wrap the head inward, and is used to stimulate the dorsolateral parietal lobe, the frontal lobe, and the medial parietal lobe, etc. Light stimulation means and power supply means are provided, and an intranasal infrared LED probe for stimulating a medial temporal lobe is connected to the headset body.
그리고 광 자극 수단들은 각 영역에서 각각 조사 방향 및 조사 세기가 다른 복수 개의 LED들이 1열 또는 다중열로 배열되고, 배열된 복수개의 LED들 중에서 특정 개수 또는 특정 위치의 LED를 선택하여 빛을 표적 부위에 조사하는 것을 특징으로 한다.And the light stimulation means is a plurality of LEDs having different irradiation directions and irradiation intensity in each area are arranged in one row or multiple rows, and a specific number or a specific position of LEDs is selected from among a plurality of arranged LEDs to direct light to the target area. It is characterized in that to investigate.
그리고 광 자극 수단들은 각각의 영역에서 복수 개의 LED를 갖고, 특정 개수 또는 특정 위치의 LED를 선택하기 위하여 알츠하이머병 억제 및 치료를 위한 진단 과정에서 획득된 영상 자료를 분석하여 환자의 두상 형태, 두상 크기, 자극이 필요한 위치 정보들을 추출하여 이를 기준으로 특정 개수 또는 특정 위치의 LED를 선택하는 것을 특징으로 한다.In addition, the light stimulation means has a plurality of LEDs in each area, and analyzes the image data acquired during the diagnosis process for Alzheimer's disease suppression and treatment in order to select a specific number or specific location of the LEDs to determine the shape and size of the patient's head. , It is characterized in that a specific number or LEDs of a specific location are selected based on this by extracting location information requiring stimulation.
이상에서 설명한 바와 같은 본 발명에 따른 알츠하이머병 환자를 위한 광치료 헤드셋은 다음과 같은 효과가 있다.The phototherapy headset for Alzheimer's disease patients according to the present invention as described above has the following effects.
첫째, 코 내부를 통해 빛을 조영하여 내측 측두엽을 자극할 수 있도록 하여 알츠하이머병 억제 및 치료 효과를 높인다.First, it is possible to stimulate the medial temporal lobe by contrasting light through the inside of the nose, thereby increasing the Alzheimer's disease suppression and treatment effect.
둘째, 코 내부를 통해 빛을 조영하고, LED의 자극부위를 상부로 변경하여 알츠하이머병의 병리의 주요 위치인 해마가 포함된 내측 측두엽과 두정엽을 효과적으로 자극할 수 있도록 한다.Second, the light is contrasted through the inside of the nose, and the stimulation site of the LED is changed to the upper part, so that the medial temporal lobe and parietal lobe including the hippocampus, which are the major locations of Alzheimer's disease, can be effectively stimulated.
셋째, 감마(gamma)(40Hz)와 알파(alpha)(10Hz) 깜빡임이 가능한 적외선(810nm) LED를 갖는 비강(鼻腔)내에 위치하는 비강 프로브(nasal probe)를 통하여 해마를 포함한 내측 측두엽(medial temporal lobe)을 효과적으로 자극할 수 있도록 한다.Third, the medial temporal lobe including the hippocampus through a nasal probe located in the nasal cavity with an infrared (810nm) LED capable of gamma (40Hz) and alpha (10Hz) flicker. lobe) can be stimulated effectively.
넷째, 외측 측두엽(dorsolateral temporal lobe) 자극 위치에서 상방향으로 자극 위치를 이동하여 외측 두정엽(dorsolateral parietal lobe)을 자극하고, 전두엽내측과 두정엽 내측을 자극하여, 디폴트 모드 네트워크(default mode network)와 기억생성과정에 관여하는 파페즈 회로(Papez’s circuit)에 최대한 접근하도록 하여 알츠하이머병 억제 및 치료 효과를 높인다.Fourth, by moving the stimulus position upward from the dorsolateral temporal lobe stimulation position to stimulate the dorsolateral parietal lobe, and to stimulate the medial frontal and parietal lobes, the default mode network and memory It increases the effectiveness of Alzheimer's disease suppression and treatment by maximizing access to Papez's circuit, which is involved in the production process.
다섯째, 광자극의 대뇌의 위치를 선정하고, 개별 환자의 뇌파를 반영하여 적외선의 깜빡임 자극의 빈도를 조절하여, 알츠하이머병 치료를 위한 광치료(photic modulation)를 효과적으로 수행할 수 있도록 한다.Fifth, the location of the cerebrum of the photostimulation is selected, and the frequency of the blinking stimulus of infrared rays is adjusted by reflecting the brain waves of individual patients, so that the phototherapy (photic modulation) for the treatment of Alzheimer's disease can be effectively performed.
여섯째, 헬멧 구조의 헤드셋 내부에 각각의 자극 수단이 위치하는 영역들의 각 영역에 조사 각도, 조사 세기, 깜박임 정도의 선택이 가능하도록 LED 등의 조사 수단들이 복수개 구비되어 자극이 필요한 위치에 정밀하게 광치료(photic modulation)를 효과적으로 수행할 수 있도록 한다.Sixth, a plurality of irradiation means such as LEDs are provided to select the irradiation angle, irradiation intensity, and degree of flicker in each area of the areas where each stimulation means is located inside the headset of the helmet structure, so that phototherapy is precisely where stimulation is required. (photic modulation) can be effectively performed.
도 1은 디폴트 모드 네트워크(Default mode network)와 알츠하이머병의 베타-아밀로이드 플라그의 분포도1 is a distribution diagram of a default mode network and beta-amyloid plaques of Alzheimer's disease
도 2a와 도 2b는 본 발명에 따른 알츠하이머병 환자를 위한 광치료 헤드셋을 이용한 광치료시의 표적 부위를 나타낸 구성도2A and 2B are configuration diagrams showing a target site during phototherapy using a phototherapy headset for a patient with Alzheimer's disease according to the present invention.
도 3은 본 발명에 따른 알츠하이머병 환자를 위한 광치료 헤드셋의 외측 및 내측 구성도3 is an outer and inner configuration diagram of a phototherapy headset for a patient with Alzheimer's disease according to the present invention
도 4는 본 발명에 따른 알츠하이머병 환자를 위한 광치료 헤드셋의 회로 구성도4 is a circuit diagram of a phototherapy headset for a patient with Alzheimer's disease according to the present invention
이하, 본 발명에 따른 알츠하이머병 환자를 위한 광치료 헤드셋의 바람직한 실시 예에 관하여 상세히 설명하면 다음과 같다.Hereinafter, a preferred embodiment of a phototherapy headset for a patient with Alzheimer's disease according to the present invention will be described in detail as follows.
본 발명에 따른 알츠하이머병 환자를 위한 광치료 헤드셋의 특징 및 이점들은 이하에서의 각 실시 예에 대한 상세한 설명을 통해 명백해질 것이다.Features and advantages of the phototherapy headset for patients with Alzheimer's disease according to the present invention will become apparent through detailed description of each embodiment below.
도 2a와 도 2b는 본 발명에 따른 알츠하이머병 환자를 위한 광치료 헤드셋을 이용한 광치료시의 표적 부위를 나타낸 구성도이다.2A and 2B are diagrams showing a target site during phototherapy using a phototherapy headset for a patient with Alzheimer's disease according to the present invention.
본 발명에 따른 알츠하이머병 환자를 위한 광치료 헤드셋은 감마(gamma)(40Hz)와 알파(alpha)(10Hz) 깜빡임이 가능한 적외선(810nm) LED를 갖는 비강(鼻腔)내에 위치하는 비강 프로브(nasal probe)를 통하여 해마를 포함한 내측 측두엽(medial temporal lobe)을 효과적으로 자극할 수 있도록 한 것이다.The phototherapy headset for patients with Alzheimer's disease according to the present invention is a nasal probe located in the nasal cavity having an infrared (810 nm) LED capable of gamma (40 Hz) and alpha (10 Hz) flicker. The medial temporal lobe, including the hippocampus, can be effectively stimulated.
또한, 외측 측두엽(dorsolateral temporal lobe) 자극 위치에서 상방향으로 자극 위치를 이동하여 외측 두정엽(dorsolateral parietal lobe)을 자극하고, 전두엽내측과 두정엽 내측을 자극하여, 디폴트 모드 네트워크(default mode network)와 기억생성과정에 관여하는 파페즈 회로(Papez’s circuit)에 최대한 접근하도록 하여 알츠하이머병 억제 및 치료 효과를 높일 수 있는 구조를 갖는다.In addition, by moving the stimulation position upward from the dorsolateral temporal lobe stimulation position to stimulate the dorsolateral parietal lobe, and to stimulate the inner frontal and parietal lobes, the default mode network and memory It has a structure that can increase Alzheimer's disease suppression and treatment effects by making it as close as possible to the Papez's circuit, which is involved in the production process.
이를 위하여 본 발명은 광자극의 대뇌의 위치를 선정하고, 개별 환자의 뇌파를 반영하여 적외선의 깜빡임 자극의 빈도를 조절하는 구성을 포함할 수 있다.To this end, the present invention may include a configuration in which a position of the cerebrum of the photostimulation is selected, and the frequency of the blinking stimulus of infrared rays is adjusted by reflecting an EEG of an individual patient.
본 발명은 헬멧 구조의 헤드셋 내부에 각각의 자극 수단이 위치하는 영역들의 각 영역에 조사 각도, 조사 세기, 깜박임 정도의 선택이 가능하도록 LED 등의 광 자극 수단들이 복수개 구비되어 자극이 필요한 위치에 정밀하게 광치료(photic modulation)를 효과적으로 수행할 수 있도록 하는 구성을 포함할 수 있다.In the present invention, a plurality of light stimulation means such as LEDs are provided to enable selection of the irradiation angle, irradiation intensity, and degree of flicker in each of the areas in which each stimulation means is located inside the headset of the helmet structure, so that it is precisely at the position where stimulation is required It may include a configuration to effectively perform phototherapy (photic modulation).
여기서, 광 자극 수단들은 각 영역에서 각각 조사 방향이 다른 LED들이 1열 또는 다중열로 배열될 수 있고, 이와 같이 배열된 복수개의 LED들 중에서 특정 개수 또는 특정 위치의 LED를 선택하여 빛을 정확하게 표적 부위에 조사하는 것에 의해 광치료 효과를 높일 수 있도록 한다.Here, the light stimulation means may be arranged in a row or multiple rows of LEDs with different irradiation directions in each area, and accurately target light by selecting a specific number or LEDs at a specific location from among a plurality of LEDs arranged in this way. The phototherapy effect can be enhanced by irradiating the area.
본 발명은 특정 개수 또는 특정 위치의 LED를 선택하기 위하여 다음과 같은 구성을 포함할 수 있다.The present invention may include the following configuration to select a specific number or a specific location of the LEDs.
본 발명의 일 실시 예에서는 알츠하이머병 억제 및 치료를 위한 진단 과정에서 획득된 영상 자료를 분석하여 환자의 두상 형태, 두상 크기, 자극이 필요한 위치 정보들을 추출하여 이를 기준으로 헬멧 구조의 헤드셋 내부에 배열된 복수개의 LED들 중에서 특정 개수 또는 특정 위치의 LED를 선택하는 것이다.In an embodiment of the present invention, image data acquired during a diagnosis process for suppression and treatment of Alzheimer's disease are analyzed to extract the shape of the patient's head, the size of the head, and location information that requires stimulation, and arrange it inside the headset of the helmet structure based on this. It is to select a specific number or a specific location of the LEDs among the plurality of LEDs.
여기서, 영상 자료를 분석하여 환자의 두상 형태, 두상 크기, 자극이 필요한 위치 정보들을 추출하는 것은 널리 사용되는 기술로 구체적인 설명을 생략한다.Here, analyzing the image data to extract the patient's head shape, head size, and location information requiring stimulation is a widely used technique, and a detailed description thereof will be omitted.
도 2a와 도 2b에서와 같이, 알츠하이머병의 병리의 주요 위치인 해마가 포함된 내측 측두엽과 두정엽을 효과적으로 자극하기 위해서, 외측 측두엽이나 후두엽(occipital area)을 자극하는 것과는 달리, 본 발명은 코 내부를 통해 빛을 조영하여, 내측 측두엽을 자극할 수 있도록 하고, 두정엽부위를 자극하고자 LED의 자극부위를 상부에 위치시킨다.2A and 2B, in order to effectively stimulate the medial temporal lobe and parietal lobe including the hippocampus, which are the major locations of the pathology of Alzheimer's disease, the present invention is different from stimulating the lateral temporal lobe or the occipital area. By contrasting the light through the to stimulate the medial temporal lobe, and to stimulate the parietal lobe, the stimulation part of the LED is placed at the top.
즉, gamma(40Hz)와 alpha(10Hz) 깜빡임이 가능한 적외선(810nm) LED를 해마를 포함한 내측 측두엽(medial temporal lobe)을 자극할 수 있도록 비강(鼻腔)내에 위치할 nasal probe를 제작하였고, 외측 두정엽(dorsolateral parietal lobe)을 자극하기 위해 기존의 외측 측두엽(dorsolateral temporal lobe) 자극 위치에서 상방향으로 이동하였다.In other words, a nasal probe to be placed in the nasal cavity was prepared to stimulate the medial temporal lobe including the hippocampus with infrared (810nm) LEDs capable of flickering gamma (40Hz) and alpha (10Hz). To stimulate the dorsolateral parietal lobe, it moved upward from the dorsolateral temporal lobe stimulation position.
또한, 전두엽내측과 두정엽 내측을 자극하여, 디폴트 모드 네트워크(default mode network)와 기억생성과정에 관여하는 파페즈 회로(Papez’s circuit)에 최대한 접근하도록 하여 알츠하이머병 억제 및 치료 효과를 높일 수 있는 구조를 갖는다.In addition, by stimulating the inside of the frontal lobe and the inside of the parietal lobe, the default mode network and Papez's circuit, which is involved in the process of memory generation, can be approached as much as possible, thereby improving the effectiveness of Alzheimer's disease suppression and treatment. Have.
이를 위한 본 발명에 따른 알츠하이머병 환자를 위한 광치료 헤드셋의 구조를 구체적으로 설명하면 다음과 같다.To this end, the structure of the phototherapy headset for Alzheimer's disease patients according to the present invention will be described in detail as follows.
도 3은 본 발명에 따른 알츠하이머병 환자를 위한 광치료 헤드셋의 외측 및 내측 구성도이다.3 is an outer and inner configuration diagram of a phototherapy headset for a patient with Alzheimer's disease according to the present invention.
해마가 포함된 내측 측두엽을 자극하기 위해, 코를 통한 프로브(probe) 제작과 양측 두정엽, 전두엽과 두정엽 내측을 자극하기 위한 LED를 배치하여, 기존의 외측 측두엽자극과 시각적 자극보다 더 알츠하이머병의 병리위치를 타겟으로 하고, 기능을 조절할 수 있도록 한다.In order to stimulate the medial temporal lobe including the hippocampus, a probe was made through the nose and LEDs to stimulate both parietal lobes, frontal and parietal lobes were placed to stimulate the pathology of Alzheimer's disease more than conventional lateral temporal lobe stimulation and visual stimulation. Target location and allow you to control functions.
알츠하이머병 환자의 뇌파는 감마 파(gamma wave)와 알파 파(alpha wave)의 진동(oscillations)이 감소되어 있어, 본 발명에서는 개별 환자의 정량뇌파측정(quantitative EEG)으로 얻어진 감마 파와 알파 파의 주요 파워 스펙트럼(power spectrum)에서 10-20% 증가된 범위에서 LED의 깜빡임을 조절하여 자극함으로서 진동(oscillation)을 회복시켜 줄 수 있도록 한다.Since the EEG of Alzheimer's disease patients has reduced oscillations of gamma and alpha waves, in the present invention, the main gamma waves and alpha waves obtained by quantitative EEG of individual patients In the range of 10-20% increase in the power spectrum, it is possible to restore the oscillation by controlling the flicker of the LED and stimulating it.
본 발명에 따른 헤드셋은 도 3에서와 같이 두부를 내측으로 위치시켜 감쌀 수 있는 헬멧 형태를 갖고, 헤드셋 본체(100)의 내부에 외측 두정엽(dorsolateral parietal lobe)과 전두엽(frontal lobe)과 내측 두정엽(medial parietal lobe) 등을 자극하기 위한 광 자극 수단들(120a)(120b)(120c)(120d)이 구비되고, 내측 측두엽(medial temporal lobe)을 자극하기 위한 비강내 적외선 LED 프로브(110)가 헤드셋 본체(100)에 연결되어 구성된다.The headset according to the present invention has a helmet shape that can be positioned and wrapped around the head as shown in FIG. 3, and the dorsolateral parietal lobe, the frontal lobe, and the medial parietal lobe ( Medial parietal lobe), light stimulation means (120a) (120b) (120c) (120d) for stimulating, etc. are provided, and an intranasal infrared LED probe 110 for stimulating the medial temporal lobe is a headset It is configured by being connected to the main body 100.
여기서, 광 자극 수단들(120a)(120b)(120c)(120d)은 각 설치 영역에서 각각 조사 방향이 다른 LED들이 1열 또는 다중열로 배열될 수 있고, 이와 같이 배열된 복수개의 LED들 중에서 특정 개수 또는 특정 위치의 LED를 선택하여 빛을 정확하게 표적 부위에 조사하는 것이 가능하도록 구성된다.Here, the light stimulation means (120a) (120b) (120c, 120d) may be arranged in one row or multiple rows of LEDs having different irradiation directions in each installation area, among a plurality of LEDs arranged in this way. It is configured so that it is possible to accurately irradiate light onto a target site by selecting a specific number or a specific location of LEDs.
본 발명은 특정 개수 또는 특정 위치의 LED를 선택하기 위하여, 알츠하이머병 억제 및 치료를 위한 진단 과정에서 획득된 영상 자료를 분석하여 환자의 두상 형태, 두상 크기, 자극이 필요한 위치 정보들을 추출하여 이를 기준으로 광 자극 수단들을 선택 제어할 수 있다.In order to select a specific number or a specific location of LEDs, the present invention analyzes the image data acquired during the diagnosis process for Alzheimer's disease suppression and treatment, extracts the patient's head shape, head size, and location information that requires stimulation, and is based on this. It is possible to select and control the optical stimulation means.
이와 같은 구조를 갖는 본 발명에 따른 알츠하이머병 환자를 위한 광치료 헤드셋은 알츠하이머병의 뇌내 병리 위치와 디폴트 모드 네트워크(default mode network)를 고려하여 광 자극 수단들의 위치를 선정하고, 알츠하이머병 환자의 정량뇌파에서 얻어진 감소된 감마 파(gamma wave)와 알파 파(alpha wave)의 진동을 증가시킬 수 있도록 10-20% 범위에서 증가된 감마와 알파 주파수의 깜빡임을 제공할 수 있도록 광 조절 헤드셋(photic modulation headset)을 구성한 것이다.The phototherapy headset for a patient with Alzheimer's disease according to the present invention having such a structure selects the position of the optical stimulation means in consideration of the location of the pathology in the brain of Alzheimer's disease and the default mode network, and quantitative EEG of the Alzheimer's disease patient. Photic modulation headset to provide increased gamma and alpha frequency flicker in the range of 10-20% to increase the vibration of the reduced gamma wave and alpha wave obtained in ).
40Hz로 깜빡이는 적외선은 알츠하이머병의 병리기전의 주요 원인인 베타-아밀로이드(beta-amyloid)의 대사에 영향을 줄 수 있다.Infrared light, which flickers at 40Hz, can affect the metabolism of beta-amyloid, a major cause of Alzheimer's disease.
따라서, 본 발명에 따른 알츠하이머병 환자를 위한 광치료 헤드셋의 사용에 의해 알츠하이머병의 병리기전과 인지기능의 개선의 효과를 기대할 수 있다.Therefore, the use of the phototherapy headset for Alzheimer's disease patients according to the present invention can be expected to improve the pathologic mechanism and cognitive function of Alzheimer's disease.
이와 같은 본 발명에 따른 알츠하이머병 환자를 위한 광치료 헤드셋의 세부 회로 구성을 설명하면 다음과 같다.A detailed circuit configuration of a phototherapy headset for a patient with Alzheimer's disease according to the present invention will be described as follows.
도 4는 본 발명에 따른 알츠하이머병 환자를 위한 광치료 헤드셋의 회로 구성도이다.4 is a circuit diagram of a phototherapy headset for a patient with Alzheimer's disease according to the present invention.
본 발명에 따른 알츠하이머병 환자를 위한 광치료 헤드셋은 알츠하이머병 환자의 정량뇌파에서 얻어진 감소된 감마 파(gamma wave)와 알파 파(alpha wave)의 진동을 증가시킬 수 있도록 감마와 알파 주파수의 깜빡임을 제공하기 위한 제어를 하는 광치료 제어부(40)와, 광치료 제어부(40)의 제어에 의해 광치료를 위하여 표적 부위에 조사하기 위한 빛을 조사하는 치료광 조사부(41)와, 감마와 알파 주파수의 깜빡임을 일정 범위에서 조절하는 파장 조절 수단(43)과, 파장 조절 수단(43)에 의해 조절된 범위의 감마와 알파 주파수의 깜빡임을 광치료 제어부(40)의 제어에 의해 선택된 표적 부위에 조사하는 광 자극 수단들(44)(45)(46)(47)을 포함한다.The phototherapy headset for patients with Alzheimer's disease according to the present invention provides flickering of gamma and alpha frequencies to increase the vibration of reduced gamma waves and alpha waves obtained from quantitative brain waves of Alzheimer's patients. The phototherapy control unit 40 for controlling the light treatment, the therapeutic light irradiation unit 41 for irradiating light to irradiate the target site for phototherapy under the control of the phototherapy control unit 40, and the blinking schedule of gamma and alpha frequencies. The wavelength control means 43 to be adjusted in the range, and the light stimulation means for irradiating the flicker of the gamma and alpha frequencies in the range adjusted by the wavelength control means 43 to the target site selected by the control of the phototherapy control unit 40 It includes (44) (45) (46) (47).
여기서, 광 자극 수단들중에서 내측 측두엽 자극부(44)는 내측 측두엽(medial temporal lobe)을 자극하기 위한 비강내 적외선 LED 프로브이다.Here, among the light stimulation means, the medial temporal lobe stimulation part 44 is an intranasal infrared LED probe for stimulating a medial temporal lobe.
그리고 광 자극 수단들은 외측 두정엽(dorsolateral parietal lobe)과 전두엽(frontal lobe)과 내측 두정엽(medial parietal lobe) 등을 자극하기 위한 외측 두정엽 자극부(45),외측 전두엽 자극부(46),내측 두정엽 자극부(47)를 포함한다.And the light stimulation means are lateral parietal lobe stimulation (45), lateral frontal lobe stimulation (46), medial parietal lobe stimulation to stimulate the dorsolateral parietal lobe, frontal lobe, and medial parietal lobe. Includes part 47.
본 발명에 따른 알츠하이머병 환자를 위한 광치료 헤드셋은 치료광 조사를 위한 광원을 위한 전원 공급부(42)가 내장되어 사용자의 편리성을 높인다.The phototherapy headset for a patient with Alzheimer's disease according to the present invention has a built-in power supply unit 42 for a light source for irradiating treatment light to increase user convenience.
그리고 광치료 제어부(40)는 환자의 뇌파 변화 데이터 및 사용시간 데이터 등을 이용하여 환자 상태 개선 정도의 추이를 추적하여 치료 효과를 높일 수 있는 방향으로 광치료 제어를 수행하도록 하는 것도 가능하다.In addition, the phototherapy control unit 40 may track a trend in the degree of improvement of the patient's condition using data on changes in brain waves and use time of the patient to perform phototherapy control in a direction that can increase the treatment effect.
본 발명에 따른 알츠하이머병 환자를 위한 광치료 헤드셋은 감마와 알파 주파수의 깜빡임으로 전환이 가능한 적외선(810nm) LED를 구비한다.The phototherapy headset for patients with Alzheimer's disease according to the present invention includes an infrared (810nm) LED that can be switched to blinking of gamma and alpha frequencies.
파장 조절 수단(43)에 의해 감마 파(gamma wave)의 깜빡임은 30-40Hz내에서 알파 파(alpha wave)의 깜빡임은 8-12Hz 범위에서 조절할 수 있다.The flicker of the gamma wave can be controlled within 30-40Hz by the wavelength control means 43 and the flicker of the alpha wave can be controlled in the range of 8-12Hz.
그리고 해마를 포함한 내측 측두엽(medial temporal lobe)을 자극할 수 있도록 비강(鼻腔)내에 위치할 비강내 적외선 LED 프로브는 ~80mW의 조사 세기를 갖고, 외측 두정엽(dorsolateral parietal lobe)과 전두엽 (frontal lobe)과 내측 두정엽(medial parietal lobe)을 자극하는 광 자극 수단들은 ~100mW의 조사 세기를 갖는 것이 바람직하다.And the intranasal infrared LED probe to be located in the nasal cavity to stimulate the medial temporal lobe including the hippocampus has an irradiation intensity of ~80mW, and the dorsolateral parietal lobe and frontal lobe It is preferable that the light stimulation means for stimulating the medial parietal lobe have an irradiation intensity of ~100mW.
이와 같은 본 발명에 따른 알츠하이머병 환자를 위한 광치료 헤드셋은 알츠하이머병의 병리기전의 이론적 배경과 개념을 바탕으로 광자극의 대뇌의 위치를 선정하고, 개별 환자의 뇌파를 반영하여 적외선의 깜빡임 자극의 빈도를 조절하여, 알츠하이머병 치료를 위한 photic modulation을 효과적으로 수행할 수 있도록 한 것이다.The phototherapy headset for patients with Alzheimer's disease according to the present invention selects the cerebral position of the photostimulation based on the theoretical background and concept of the pathologic mechanism of Alzheimer's disease, and reflects the brain waves of individual patients, and the frequency of the flickering stimulation of infrared rays. By controlling, it is possible to effectively perform photic modulation for Alzheimer's disease treatment.
이상에서 설명한 본 발명에 따른 알츠하이머병 환자를 위한 광치료 헤드셋은 감마(gamma)(40Hz)와 알파(alpha)(10Hz) 깜빡임이 가능한 적외선(810nm) LED를 갖는 비강(鼻腔)내에 위치하는 비강 프로브(nasal probe)를 통하여 해마를 포함한 내측 측두엽(medial temporal lobe)을 효과적으로 자극할 수 있도록 한 것이다.The phototherapy headset for Alzheimer's disease patients according to the present invention described above is a nasal probe located in the nasal cavity having an infrared (810nm) LED capable of gamma (40Hz) and alpha (10Hz) flickering ( The medial temporal lobe including the hippocampus can be effectively stimulated through a nasal probe.
이상에서의 설명에서와 같이 본 발명의 본질적인 특성에서 벗어나지 않는 범위에서 변형된 형태로 본 발명이 구현되어 있음을 이해할 수 있을 것이다.As described above, it will be understood that the present invention is implemented in a modified form without departing from the essential characteristics of the present invention.
그러므로 명시된 실시 예들은 한정적인 관점이 아니라 설명적인 관점에서 고려되어야 하고, 본 발명의 범위는 전술한 설명이 아니라 특허청구 범위에 나타나 있으며, 그와 동등한 범위 내에 있는 모든 차이점은 본 발명에 포함된 것으로 해석되어야 할 것이다.Therefore, the specified embodiments should be considered from a descriptive point of view rather than a limiting point of view, and the scope of the present invention is indicated in the claims rather than the above description, and all differences within the scope equivalent thereto are included in the present invention. It will have to be interpreted.
본 발명은 광치료 장치에 관한 것으로, 구체적으로 코 내부를 통해 빛을 조영하여 내측 측두엽을 자극할 수 있도록 하여 알츠하이머병 억제 및 치료 효과를 높인 알츠하이머병 환자를 위한 광치료 헤드셋에 관한 것이다.The present invention relates to a phototherapy device, and more specifically, to a phototherapy headset for Alzheimer's disease patients, which enhances the Alzheimer's disease suppression and treatment effect by contrasting light through the inside of the nose to stimulate the medial temporal lobe.

Claims (10)

  1. 개체의 최소한 하나의 뇌 영역에서 동기화된 감마 진동과 알파 진동을 선택적으로 유도하기 위한 광 자극 수단들;을 구비하고,And optical stimulation means for selectively inducing synchronized gamma vibration and alpha vibration in at least one brain region of the individual,
    상기 광 자극 수단들은 해마를 포함한 내측 측두엽(medial temporal lobe)을 자극할 수 있도록 비강(鼻腔)내에 위치할 비강내 적외선 LED 프로브;를 포함하는 것을 특징으로 하는 알츠하이머병 환자를 위한 광치료 헤드셋.The light stimulation means is an intranasal infrared LED probe to be located in the nasal cavity so as to stimulate the medial temporal lobe including the hippocampus; a phototherapy headset for a patient with Alzheimer's disease, characterized in that it comprises.
  2. 제 1 항에 있어서, 상기 광 자극 수단들은,The method of claim 1, wherein the light stimulation means,
    외측 두정엽(dorsolateral parietal lobe) 또는 전두엽 (frontal lobe) 또는 내측 두정엽(medial parietal lobe)을 자극하는 위치에 각각 구성되는 광 자극 수단들을 포함하는 것을 특징으로 하는 알츠하이머병 환자를 위한 광치료 헤드셋.A phototherapy headset for Alzheimer's disease patients, comprising light stimulation means each configured at a position to stimulate the dorsolateral parietal lobe or the frontal lobe or the medial parietal lobe.
  3. 제 1 항 또는 제 2 항에 있어서, 상기 광 자극 수단들 중에서 비강내 적외선 LED 프로브는 ~80mW의 조사 세기를 갖고, The method of claim 1 or 2, wherein among the light stimulation means, the intranasal infrared LED probe has an irradiation intensity of ~80mW,
    외측 두정엽(dorsolateral parietal lobe) 또는 전두엽 (frontal lobe) 또는 내측 두정엽(medial parietal lobe)을 자극하는 위치에 각각 구성되는 광 자극 수단들은 ~100mW의 조사 세기를 갖는 것을 특징으로 하는 알츠하이머병 환자를 위한 광치료 헤드셋.Phototherapy for Alzheimer's disease patients, characterized in that the light stimulation means each configured at a position to stimulate the dorsolateral parietal lobe, frontal lobe, or medial parietal lobe have an irradiation intensity of ~100mW headset.
  4. 제 1 항에 있어서, 상기 광 자극 수단들은,The method of claim 1, wherein the light stimulation means,
    감마와 알파 주파수의 깜빡임으로 전환이 가능한 적외선(810nm) LED를 구비하고,Equipped with an infrared (810nm) LED that can be switched between gamma and alpha frequency flicker,
    파장 조절 수단에 의해 감마 파(gamma wave)의 깜빡임은 30-40Hz내에서 알파 파(alpha wave)의 깜빡임은 8-12Hz 범위에서 조절하는 것을 특징으로 하는 알츠하이머병 환자를 위한 광치료 헤드셋.A phototherapy headset for Alzheimer's disease patients, characterized in that the flickering of the gamma wave is controlled within 30-40Hz and the flickering of the alpha wave is in the range of 8-12Hz by the wavelength control means.
  5. 알츠하이머병 환자의 정량뇌파에서 얻어진 감소된 감마 파(gamma wave)와 알파 파(alpha wave)의 진동을 증가시킬 수 있도록 감마와 알파 주파수의 깜빡임을 제공하기 위한 제어를 하는 광치료 제어부;A phototherapy control unit that controls to provide flickering of gamma and alpha frequencies to increase vibrations of reduced gamma waves and alpha waves obtained from quantitative brain waves of Alzheimer's disease patients;
    광치료 제어부의 제어에 의해 광치료를 위하여 표적 부위에 조사하기 위한 빛을 조사하는 치료광 조사부;A treatment light irradiation unit for irradiating light to irradiate a target site for phototherapy under the control of the phototherapy controller;
    감마와 알파 주파수의 깜빡임을 일정 범위에서 조절하는 파장 조절 수단;A wavelength control means for controlling flickering of gamma and alpha frequencies within a predetermined range;
    파장 조절 수단에 의해 조절된 범위의 감마와 알파 주파수의 깜빡임을 광치료 제어부의 제어에 의해 선택된 표적 부위에 조사하는 광 자극 수단들;을 포함하는 것을 특징으로 하는 알츠하이머병 환자를 위한 광치료 헤드셋.A phototherapy headset for a patient with Alzheimer's disease, comprising: light stimulation means for irradiating the flicker of the gamma and alpha frequencies in the range adjusted by the wavelength control means to the target site selected by the control of the phototherapy control unit.
  6. 제 5 항에 있어서, 광 자극 수단들은,The method of claim 5, wherein the light stimulation means,
    해마를 포함한 내측 측두엽(medial temporal lobe)을 자극할 수 있도록 비강(鼻腔)내에 위치할 비강내 적외선 LED 프로브와,An intranasal infrared LED probe to be placed in the nasal cavity to stimulate the medial temporal lobe including the hippocampus, and
    외측 두정엽(dorsolateral parietal lobe) 또는 전두엽 (frontal lobe) 또는 내측 두정엽(medial parietal lobe)을 자극하는 위치에 각각 구성되는 광 자극 수단들을 포함하는 것을 특징으로 하는 알츠하이머병 환자를 위한 광치료 헤드셋.A phototherapy headset for Alzheimer's disease patients, comprising light stimulation means each configured at a position to stimulate the dorsolateral parietal lobe or the frontal lobe or the medial parietal lobe.
  7. 제 1 항 또는 제 5 항에 있어서, 감마 파(gamma wave)와 알파 파(alpha wave)의 진동(oscillations)이 감소되어 있는 알츠하이머병 환자의 정량뇌파측정(quantitative EEG)으로 얻어진,The method according to claim 1 or 5, obtained by quantitative EEG of Alzheimer's disease patients with reduced oscillations of gamma and alpha waves,
    감마 파와 알파 파의 파워 스펙트럼(power spectrum)에서 10-20% 증가된 범위에서 광 자극 수단의 LED의 깜빡임을 조절하여 자극하여 진동(oscillation)이 회복되도록 하는 것을 특징으로 하는 알츠하이머병 환자를 위한 광치료 헤드셋.Phototherapy for Alzheimer's disease patients, characterized in that the oscillation is restored by stimulating by controlling the blinking of the LED of the optical stimulation means in the range of 10-20% increase in the power spectrum of the gamma wave and the alpha wave. headset.
  8. 제 1 항 또는 제 5 항에 있어서, 광치료 헤드셋은,The method of claim 1 or 5, wherein the phototherapy headset,
    두부를 내측으로 위치시켜 감쌀 수 있는 헬멧 형태를 갖고, 헤드셋 본체의 내부에 외측 두정엽(dorsolateral parietal lobe)과 전두엽(frontal lobe)과 내측 두정엽(medial parietal lobe) 등을 자극하기 위한 광 자극 수단들 및 전원 공급 수단이 구비되고,Light stimulating means for stimulating a dorsolateral parietal lobe, a frontal lobe, and a medial parietal lobe, etc., in the form of a helmet that can be positioned and wrapped around the head, and A power supply means is provided,
    내측 측두엽(medial temporal lobe)을 자극하기 위한 비강내 적외선 LED 프로브가 헤드셋 본체에 연결되어 구성되는 것을 특징으로 하는 알츠하이머병 환자를 위한 광치료 헤드셋.A phototherapy headset for Alzheimer's disease patients, characterized in that the intranasal infrared LED probe for stimulating the medial temporal lobe is connected to the headset body.
  9. 제 1 항 또는 제 5 항에 있어서, 광 자극 수단들은 각 영역에서 각각 조사 방향 및 조사 세기가 다른 복수 개의 LED들이 1열 또는 다중열로 배열되고,The method of claim 1 or 5, wherein the light stimulation means are arranged in one row or multiple rows of a plurality of LEDs having different irradiation directions and irradiation intensity, respectively, in each area,
    배열된 복수개의 LED들 중에서 특정 개수 또는 특정 위치의 LED를 선택하여 빛을 표적 부위에 조사하는 것을 특징으로 하는 알츠하이머병 환자를 위한 광치료 헤드셋.A phototherapy headset for Alzheimer's disease patients, characterized in that light is irradiated to a target site by selecting a specific number or a specific location of LEDs from among a plurality of arranged LEDs.
  10. 제 1 항 또는 제 5 항에 있어서, 광 자극 수단들은 각각의 영역에서 복수 개의 LED를 갖고,The method according to claim 1 or 5, wherein the light stimulation means have a plurality of LEDs in each area,
    특정 개수 또는 특정 위치의 LED를 선택하기 위하여 알츠하이머병 억제 및 치료를 위한 진단 과정에서 획득된 영상 자료를 분석하여 환자의 두상 형태, 두상 크기, 자극이 필요한 위치 정보들을 추출하여 이를 기준으로 특정 개수 또는 특정 위치의 LED를 선택하는 것을 특징으로 하는 알츠하이머병 환자를 위한 광치료 헤드셋.In order to select a specific number or specific location of LEDs, by analyzing the image data acquired during the diagnosis process for Alzheimer's disease suppression and treatment, extract the patient's head shape, head size, and location information that requires stimulation, and based on this, a specific number or A phototherapy headset for Alzheimer's disease patients, characterized in that the LED in a specific location is selected.
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