WO2021187877A1

WO2021187877A1 - Device for personalized treatment of tinnitus and computer-readable recording medium for performing same

Info

Publication number: WO2021187877A1
Application number: PCT/KR2021/003258
Authority: WO
Inventors: 구윤서; 김희찬; 안중우; 오승하
Original assignee: 충남대학교산학협력단; 서울대학교병원
Priority date: 2020-03-20
Filing date: 2021-03-16
Publication date: 2021-09-23
Also published as: KR102185269B1

Abstract

According to various embodiments, a device for personalized treatment of tinnitus can comprise: a speaker; a first electrode, which includes an emission hole formed so that a first sound stimulation using the speaker is outputted to the outside, has a form that can be mounted on a part of a user's ear, and can output a current stimulation; and one or more second electrodes for detecting user's biosignals generated in response to the output of the first sound stimulation.

Description

Apparatus for personalized tinnitus treatment and computer-readable recording medium for performing the same

The present invention relates to an apparatus for personalized tinnitus treatment and a computer-readable recording medium for performing the same.

Conventional tinnitus treatment is mainly performed by masking using a hearing aid and adaptive rehabilitation training, and there is no standard treatment for substantially reducing tinnitus. Also, conventionally, various treatments such as drugs such as betahistine and transcranial magnetic stimulation (TMS) have been proposed, but their effectiveness has not been confirmed.

Recently, research on the treatment of tinnitus using a neuromodulation technique that enhances brain plasticity by simultaneously applying sound and electrical stimulation has been actively conducted. Bimodal stimulation therapy, an invasive method that requires surgery or a non-invasive method that can be treated without surgery, has been proposed. For example, treatments for attempting to treat tinnitus in a patient by electrical stimulation of a vagus nerve and/or a trigeminal nerve at the same time as sound stimulation have been proposed.

In the invasive or non-invasive treatment studies proposed above, various stimulation conditions such as treatment period, sound/electrical stimulation intensity and time are generally applied to all tinnitus patients. According to the results of the study, the duration of the effect of tinnitus treatment differs for each patient, and there are cases where the treatment is not effective for some patients. Therefore, there is a need for personalized treatment that adjusts various stimulation conditions based on diagnosis during treatment in daily life, but the currently proposed tinnitus treatment devices do not include a structure for observing the treatment effect.

In addition, the invasive treatment method has a disadvantage in that a current stimulator must be implanted in the patient's body through surgery to directly stimulate the vagus nerve.

In addition, the non-invasive treatment method has the advantage of not having surgery, but has a disadvantage in that a relatively long treatment time of 30 minutes or more per day must be performed in a situation where the movement of the patient is restricted. For example, in the case of a non-invasive current stimulation method in which an electrode is placed under the tongue to stimulate the trigeminal nerve, the patient has to keep biting the electrode, so movement is limited during treatment and daily activities are difficult. There are disadvantages.

An embodiment of the present invention provides an apparatus, method, computer-readable recording medium and A computer program may be provided.

For example, the present invention can diagnose tinnitus based on the response of EEG in response to a sound stimulus, enabling personalized tinnitus treatment based on the diagnosis of tinnitus.

An embodiment of the present invention may provide an apparatus, method, computer-readable recording medium, and computer program for a non-invasive, personalized tinnitus treatment capable of simultaneously applying sound and electric current stimulation.

For example, the present invention may provide a way to non-invasively stimulate a branch of the vagus nerve and/or trigeminal nerve at or near a patient's ear.

For example, the present invention can provide a personalized tinnitus treatment device in the form of a headset familiar to all patients and capable of treating tinnitus in daily life. The headset-type personalized tinnitus treatment device can provide both current stimulation and sound stimulation at or near the ear, thereby minimizing movement restrictions of the patient.

According to various embodiments, in an apparatus for personalized tinnitus treatment, it includes a speaker and an outlet formed so that the first sound stimulus through the speaker is output to the outside, has a shape that can be mounted on a part of the user's ear, and has a current It may include a first electrode capable of outputting a stimulus and one or more second electrodes detecting a user's biosignal generated in response to the output of the first sound stimulus.

According to various embodiments, the device further includes a cable electrically connected to the speaker and the first electrode, wherein the one or more second electrodes are located at at least a portion of the cable and be electrically connected to the cable. can

According to various embodiments, at least a portion of the cable on which the second electrode is positioned may include a portion of an auricular branch of vagus nerve in the ear or an in-the-ear, ear canal portion or auricle. It may include a predetermined portion to correspond to the back-the-ear portion of the scalp.

According to various embodiments, the user's biosignal includes the user's brainwave, and further comprises a control device electrically connected to the cable, wherein the control device includes, based on the detected biosignal, the user's The tinnitus diagnosis may be performed, and the output of the second sound stimulus through the speaker and the current stimulus through the first electrode may be controlled based on the result of the user's tinnitus diagnosis.

According to various embodiments, the device includes an outlet formed so that the first sound stimulus through the other speaker is output to the outside, has a shape that can be mounted on a part of the user's ear, and receives current or voltage stimulation first additional electrode capable of output It further includes one or more second additional electrodes for detecting a user's biosignal generated in response, and the other cable may be electrically connected to the control device.

According to various embodiments, the first sound stimulus includes a first stimulus sound including a pulse noise and a first background noise, and a second background sound having a silent gap between the pulse sound and the sound stimulus. It may include a plurality of second stimulation sounds including.

According to various embodiments of the present disclosure, the control device may include a first waveform of the user's auditory evoked potential according to the first stimulation sound and a plurality of second waveforms of the user's auditory evoked potential according to the plurality of second stimulation sounds The tinnitus diagnosis of the user may be performed by detecting waveforms and calculating a plurality of gap prepulse inhibition (GPI) ratios that are ratios between the amplitudes between the poles of the first waveform and the amplitudes between the poles of the plurality of second waveforms.

According to various embodiments, the control device controls the output of the second sound stimulus and the first electrode based on the pre-stored sound stimulus parameter and current stimulus parameter for each tinnitus type and the result of the user's tinnitus diagnosis. It is possible to control the output of the current stimulus through the

According to various embodiments, the device further includes an optical sensor, wherein the control device outputs the second sound stimulus through the speaker and the current stimulus through the first electrode while the one The user's electrocardiogram (ECG) may be measured through the second electrode, and the user's photoplethysmogram (PPG) may be measured using the optical sensor.

According to various embodiments of the present disclosure, the controller may check the heart rate variability of the user based on the measured electrocardiogram and the measured photoplethysmogram, and may include stress information corresponding to each preset heart rate variability and the checked heart rate variability. It is possible to determine the user's stress value based on

According to various embodiments, the control device determines the heart rate and respiration rate of the user based on the measured electrocardiogram and the measured photoplethysmography wave, and when the determined heart rate and respiration rate exceed a preset threshold range, The output of the second sound stimulus through the speaker and the output of the current stimulus through the first electrode may be controlled to be stopped or reduced.

According to various embodiments, the control device controls the output of the second sound stimulus and the output of the current stimulus through the first electrode to be terminated based on a specified reference time, and the output of the second sound stimulus and the output of the current stimulus through the first electrode are terminated. After the output of the current stimulation through the first electrode is finished, the user's bio-signals are re-detected through the one or more second electrodes, and based on the re-detected bio-signals, the user's tinnitus diagnosis is re-performed And, by comparing the results of the performed tinnitus diagnosis with the results of the re-performed tinnitus diagnosis, the degree of effectiveness of the tinnitus treatment can be determined.

According to various embodiments, the biosignal may further include a signal for recording an electrocardiogram.

According to various embodiments, in a method for personalized tinnitus treatment using a device, outputting a first sound stimulus through a speaker of the device, and responding to the output of the first sound stimulus through a detection electrode of the device Detecting the user's bio-signal, which is generated through 2 outputting a sound stimulus and outputting a current stimulus through one or more current stimulus applying electrodes of the device.

According to various embodiments, as a computer-readable recording medium storing a computer program, when the computer program is executed by a processor, outputting a first sound stimulus through a speaker of the device; detecting a user's biosignal generated in response to the output of the first sound stimulus through the method; performing tinnitus diagnosis of the user based on the EEG included in the detected biosignal; and tinnitus diagnosis of the user may include instructions for causing the processor to perform a method comprising outputting a second sound stimulus through the speaker and outputting a current stimulus through one or more current stimulus applying electrodes of the device based on a result of have.

According to various embodiments, as a computer program stored in a computer-readable recording medium, when the computer program is executed by a processor, outputting a first sound stimulus through a speaker of the device; detecting a user's biosignal generated in response to the output of the first sound stimulus through the method; performing tinnitus diagnosis of the user based on the EEG included in the detected biosignal; and tinnitus diagnosis of the user may include instructions for causing the processor to perform a method comprising outputting a second sound stimulus through the speaker and outputting a current stimulus through one or more current stimulus applying electrodes of the device based on a result of have.

According to various embodiments, in an apparatus for personalized tinnitus treatment, it includes a speaker and an outlet formed so that the first sound stimulus through the speaker is output to the outside, has a shape that can be mounted on a part of the user's ear, and has a current Alternatively, it may include an electrode that outputs a voltage stimulus and detects a user's biosignal generated in response to the output of the first sound stimulus.

The apparatus, method, computer-readable recording medium and computer program for personalized tinnitus treatment according to an embodiment of the present invention enable tinnitus diagnosis and treatment in one device to track the treatment effect, and accordingly It is possible to improve the efficiency of tinnitus treatment by applying personalized stimulation rather than giving the same stimulation to all patients.

For example, the present invention can manufacture a wearable type tinnitus treatment device, and a patient in need of tinnitus treatment can be provided with tinnitus treatment for a required time without restriction of location and movement.

The apparatus, method, computer-readable recording medium, and computer program for personalized tinnitus treatment according to an embodiment of the present invention check the patient's respiratory rate and/or heart rate information to secure the patient's treatment safety and the patient's stress aspect It can make it possible to evaluate the treatment of tinnitus in

1 is a block diagram of an apparatus for personalized tinnitus treatment according to an embodiment of the present invention.

2 and 3 are diagrams for explaining the structure of an apparatus for personalized tinnitus treatment according to an embodiment of the present invention.

4 is a diagram for explaining the operation of an apparatus for personalized tinnitus treatment according to an embodiment of the present invention.

5 is a view for explaining a stimulation waveform provided for the treatment of tinnitus according to an embodiment of the present invention.

6 is a view for explaining a stimulation waveform provided for the treatment of tinnitus according to an embodiment of the present invention.

7 is a flowchart illustrating an operation and method of an apparatus for treating tinnitus according to an embodiment of the present invention.

8 is a flowchart of an operation for treating tinnitus according to an embodiment of the present invention.

9 is a block diagram of an apparatus for personalized tinnitus treatment according to an embodiment of the present invention.

10 and 11 are diagrams for explaining the structure of an apparatus for personalized tinnitus treatment according to an embodiment of the present invention.

Hereinafter, the embodiment will be described in detail with reference to the drawings.

First, the advantages and features of the present invention, and a method for achieving them will become clear with reference to the embodiments described below in detail in conjunction with the accompanying drawings. Here, the present invention is not limited to the embodiments disclosed below, but may be implemented in a variety of different forms, and only these embodiments allow the disclosure of the present invention to be complete, and are common in the technical field to which the present invention pertains. The technical scope of the present invention should be defined by the claims since it is provided by way of example so that those with knowledge can clearly understand the scope of the invention.

In addition, in the following description of the present invention, if it is determined that a detailed description of a well-known function or configuration may unnecessarily obscure the gist of the present invention, the detailed description thereof will be omitted. And, the terms to be described later are terms defined in consideration of functions in the present invention, which may vary depending on the intentions or customs of users, operators, etc., of course. Therefore, the definition should be made based on the technical idea described throughout this specification.

Tinnitus is a symptom of hearing sound in the ear in the absence of external auditory stimulation. For the treatment of tinnitus, conventionally, a method of providing a stimulus for treatment to all tinnitus patients has been used instead of a customized tinnitus treatment based on tinnitus diagnosis. Accordingly, there are people who have no effect on treatment, and the duration of the effect also differs from person to person. An embodiment of the present invention provides tinnitus diagnosis for a patient, provides tinnitus treatment based on tinnitus diagnosis, and provides a patient according to the tinnitus treatment so that the patient can receive great convenience in tinnitus treatment by supplementing the above conventional problems. By monitoring changes of

As an example of the treatment of tinnitus, a method of current stimulation of the vagus nerve, the trigeminal nerve, and/or the cervical spinal cord at the same time as sound stimulation may be used. Conventionally, an invasive method through surgery has been used to directly stimulate the vagus nerve, but an embodiment of the present invention proposes a method capable of non-invasively stimulating a branch of the vagus nerve in the ear. In addition, in the prior art, a user has to bite the electrode so that the electrode is positioned under the tongue to stimulate the trigeminal nerve, but the present invention proposes a method of stimulating a branch of the trigeminal nerve in the ear. An embodiment of the present invention is focused on the fact that, when sound stimulation is provided while giving current stimulation to the ear, it is possible to manufacture a very small type of integrated tinnitus treatment device (device), for example, the tinnitus treatment device in the form of a headset. In the case of producing a tinnitus, the user can receive stimulation for tinnitus treatment while performing daily life without restriction of movement.

Hereinafter, embodiments of the present invention will be described in detail with reference to the accompanying drawings.

Referring to FIG. 1 , the device 100 may include a control device 110 , a stimulation module 130 , a measurement module 150 , a memory 170 , and/or an optical sensor 390 .

The control device 110 (also referred to as a control circuit or processor) may include at least one other component (eg, a hardware component (eg, a measurement module 150 , a stimulation module 130 , a memory 170 ) of the connected device 100 . ) and/or optical sensor 190) or a software component (eg, software 180), and may perform various data processing and calculations.

The stimulation module 130 may include a first electrode 143 , a digital analog converter (DAC) 131 , and/or a current stimulation circuit 133 . A signal transmitted from the control device 110 may be transmitted to the first electrode 141 through the DAC 131 and the current stimulation circuit 133 . The stimulation module 130 may include a digital analog converter (DAC) 135 , an audio amplifier 137 , and/or a speaker 139 . The signal transmitted from the control device 110 may be transmitted to the speaker 139 through the DAC 135 and the audio amplifier 137 . The current stimulation circuit 133 may generate a current stimulation to be provided to the user through the first electrode 143 under the control of the controller 110 . The speaker 139 may output (provide to a user) a sound stimulus under the control of the control device 110 .

The measurement module 130 may include a second electrode 143 , an analog front-end 151 , and/or an analog digital converter (ADC) 153 . The signal detected through the second electrode 141 may be transmitted to the control device 110 through the Analog Front-End 151 and the ADC 153 . The second electrode 143 may be used to detect (measure, confirm) the user's brain waves (response of brain waves) under the control of the control device 110 . The second electrode 141 may be used to detect an electrocardiogram (ECG) or impedance of a user under the control of the controller 110 .

The memory 170 includes various data used by at least one component of the device 100 (eg, the control device 110 , the measurement module 150 , the stimulation module 130 , and/or the optical sensor 190 ). , for example, may store input data or output data for the software 180 (eg, a program) and instructions related thereto. The memory 170 may include a volatile memory or a non-volatile memory. The software 180 may be a software program for personalized tinnitus treatment according to an embodiment of the present invention.

The optical sensor 390 (also referred to as a photoplethysmogram (PPG) sensor) may detect a photoplethysmogram (PPG) signal of the user.

Some of the above-described components of FIG. 1 may be omitted (not included) or integrated into a single entity to perform the same or similar functions performed by each corresponding component prior to integration, Other components may be added. For example, the device 100 may not include the optical sensor 390 .

Referring to FIG. 2 , the device 100 may be a headset (or earphone) type device (also referred to as a device) for treating tinnitus capable of bimodal stimulation and EEG measurement as shown in FIG. 2A . The bimodal stimulation may include sound stimulation and current stimulation.

The device 100, as shown in Fig. 2 (b), in the external acoustic meatus 11, focusing on the fact that a number of branches of the vagus nerve are distributed, innervation of the external auditory meatus 11 (external) It can be implemented as a structure 1400 including a current stimulation applying electrode (first electrode 143) and a reference electrode 144 that can provide electrical stimulation to the ear canal 11 based on ear innervation. . The first electrode 143 may be referred to as a cathode and the reference electrode 144 may also be referred to as an anode. For example, the device 100 may include a structure 1400 including a first electrode 143 and a reference electrode 144 that can be mounted on a portion of a user's ear. The structure 1400 may have the same shape as in FIG. 2(b) or FIG. 2(c). For example, referring to (b) of FIG. 2, each of the first electrode 143 and the reference electrode 144 included in the structure 1400 has an outlet ( 121) may be spaced apart from each other in a direction parallel to the position. Referring to FIG. 2C , each of the first electrode 143 and the reference electrode 144 included in the structure 1400 is perpendicular to the position of the discharge port 121 as shown in FIG. 2C . direction may be spaced apart from each other. In addition, the apparatus 100 may further include one or more measuring electrodes (second electrode 145 ) positioned on at least a portion of the cable 123 connected to a portion of the first electrode 143 . The first electrode 143 may be located at a portion corresponding to the auricular branch of vagus nerve 13 when the user wears the device 100 . The structure 1400 may include an outlet 121 (also referred to as a hole) formed to output a sound stimulus through the speaker 159 to the outside (formed to be output to the user's ear), and can apply a current stimulus have. The one or more measuring electrodes may be located on a part of an ear in which a branch of a person's vagus nerve or trigeminal nerve is distributed, or at least a part of the cable 123 around the ear. For example, the one or more measuring electrodes may include a second electrode 145 , a third electrode 147 and a fourth electrode 149 having the same function as the second electrode 145 , and the third The electrode 147 and the fourth electrode 149 may be respectively located in portions of the cable 123 corresponding to innervation of the external auditory meatus in which a plurality of branches of the vagus nerve or trigeminal nerve are distributed. For example, the third electrode 147 and the fourth electrode 149 may be positioned at a portion corresponding to the auriculotemporal nerve 15 when the user wears the device 100 . .

The shape of the cable 123 is changed according to an external force, and although the shape is changed according to an element that can maintain the changed shape even if the external force is removed or an external force is removed, the cable 123 is changed again when the external force is removed. It may be an elastic element that can return to its original shape.

On the other hand, the shape of the device 100 as in (a) of FIG. 2 described above is an example, and can be implemented (manufactured) by changing into various shapes that can be mounted on the user's ear. For example, referring to FIG. 3 , the apparatus 100 for treating tinnitus may have one or more electrodes in which current stimulation can be performed in the pinna (concha). The device 100 may be implemented based on the user's auricle structure as shown in FIG. 3 , and the device 100 includes a two-channel electrode, for example, a first electrode capable of providing current stimulation to the user. It may include an electrode 143 and a fifth electrode 146 . The first electrode 143 and the fifth electrode 146 may be referred to as a cathode. As an electrode that provides current stimulation, the first electrode 143 and the fifth electrode 146 may be changed and used according to the stimulation effect. Also, the device 100 may include a reference electrode 144 for current stimulation and measurement of a user's biosignal. When a current is stimulated, the reference electrode 144 may be referred to as an anode. For example, when the user wears the device 100 , the first electrode 143 and the fifth electrode 146 are aVNS corresponding to the auricular branch of vagus nerve (aVNS). ) can be located.

In addition, the structure 1400 including the first electrode 143 and the reference electrode 142 as shown in (b) and (c) of FIG. 2 is an example, and the first electrode 143 and the reference electrode 142 may be disposed at various locations on the structure 1400 .

Referring to FIG. 4 , under the control of the control device 110 , a sound stimulus (gap-prepulse inhibition) 1001 pre-stored in the memory 170 or generated by the control device 110 is generated by the speaker 159 . may be output through , and in this case, the user's brainwave response (auditory evoked potential) may be measured 1003 through the one or more electrodes 145 . The control device 110 may diagnose the user's tinnitus (determining whether the user has tinnitus, the degree of tinnitus (also referred to as tinnitus size) and tinnitus frequency) based on the measured EEG response.

According to an embodiment, the control device 110 controls the vagus nerve stimulation 1005 through the first electrode 143 and the sound stimulation 1007 through the speaker 159 based on the result of the tinnitus diagnosis. By providing (neuromodulation), the user's tinnitus treatment can be executed. For example, the control device 110 may adjust the treatment time and stimulation intensity based on the user's degree of tinnitus to enable personalized tinnitus treatment.

According to an embodiment, the control device 110 may execute the software 180 to generate a pre-pulse interval method sound stimulus and output it through the speaker 159 . For example, the pre-pulse interval method sound stimulation includes a first stimulation sound including a background noise and a pulse noise, and a second stimulation sound including a background sound and a pulse sound having a silent gap. It may contain stimuli. The background sound represents a sound that is sustained for a predetermined time with a predetermined frequency and a predetermined amplitude, and the pulsed sound indicates a sound having a greater intensity than the background sound for a shorter time than the predetermined time during which the background sound is maintained.

According to an embodiment, the control device 110 may measure the user's brain wave response according to the pre-pulse interval method sound stimulus using the one or more measuring electrodes 145 . For example, the control device 110 may include a first waveform of an auditory evoked potential (AEP) of the user according to the first stimulation sound and a second waveform of the user's auditory evoked potential according to the second stimulation sound. Waveforms can be measured. The auditory evoked potential is a potential generated in the auditory pathway from the cochlea of the inner ear to the auditory cortex of the cerebrum after the generation of a sound stimulus. are separated Among them, the potential generated in the brainstem within about 10ms after the occurrence of a sound stimulus is called the auditory brainstem response, and in the auditory brainstem response, seven positive poles from I to VII are appear. In addition, the response occurring in the thalamo-cortical pathway between the brainstem and the cerebral auditory cortex can be called the auditory middle-latency response, and it is named N0, P0, Na, Pa, Nb, and Pb. poles appear. Finally, the response that occurs in the cerebral auditory cortex can be called the auditory late response, and typically includes poles called P1, N1, P2, and N2. The amplitude of the poles named in the embodiment of the present invention may mean the amplitude of one or more poles among a plurality of poles appearing in the auditory evoked potential, and is not limited to any pole. Also, the amplitude may be the amplitude of the poles themselves (baseline-to-peak) or the amplitude between the poles (peak-to-peak).

According to an embodiment, the control device 110 determines whether the user has tinnitus by calculating a gap prepulse inhibition ratio (GPI), which is a ratio between the amplitude between the poles of the first waveform and the amplitude between the poles of the second waveform ( test, diagnosis). For example, in the case of a user with tinnitus symptoms, the difference between the auditory evoked potentials according to the first and second stimulus sounds is small, so the GPI may be close to 1, and general users without tinnitus symptoms (general user group) The GPI of tinnitus may appear smaller than the GPI of a user with tinnitus symptoms. For example, the control device 110 receives the GPI, measures it from a group of tinnitus users having tinnitus symptoms and a general user group without tinnitus symptoms, and based on reference GPI values pre-stored in the memory 170 . , you can decide whether or not the user has a tinnitus.

According to an embodiment, the control device 110 receives a plurality of GPI ratios determined from the user, and varies the amplitude or frequency of the background sound for the tinnitus user group and the general user group based on the measured amplitude and GPI. Based on the classification models derived and stored in advance, the user's tinnitus degree and tinnitus frequency may be determined.

According to an embodiment, the control device 110 is configured to provide a treatment method (treatment time and stimulus (sound stimulation) and/or current stimulation) intensity, etc.) may be determined (set, confirmed). For example, the memory 170 may store a corresponding treatment method (treatment time and/or stimulation (sound stimulation and/or current stimulation) intensity) for each of a plurality of tinnitus diagnosis types (tinnitus severity and/or tinnitus frequency). may be stored, and a treatment method for tinnitus treatment of the user may be determined according to the user's tinnitus diagnosis based on a treatment method corresponding to each of the plurality of tinnitus diagnosis types stored in the memory 170 .

According to an embodiment, the control device 110 may allow the user to receive tinnitus treatment based on the determined treatment method (treatment time and/or intensity of stimulation (sound stimulation and/or current stimulation) for treatment). have. For example, the control device 110 may provide sound stimulation through the speaker 159 and/or current stimulation through the first electrode 143 .

According to an embodiment, according to the control of the controller 110, the user's bio-signals are detected through one or more electrodes 141 or a separate optical sensor 190, for example, an electrocardiogram (ECG). , impedance and/or photoplethysmogram (PPG) may be measured, and information on the user's respiration and heart rate may be determined (extracted) based on the biosignal.

For example, the one or more electrodes 141 included in the measurement module 150 detects a user's bio-signal (eg, electrocardiogram (ECG) or impedance) according to the control of the controller 110 . can be measured). For example, the photosensor 190 may detect a user's biosignal, for example, measure a photoplethysmogram (PPG) according to the control of the controller 110 .

According to an embodiment, the control device 110 checks (extracts) the heart rate and/or respiration rate of the user based on the biosignal detected through the measurement module 150 and/or the optical sensor 190 . )can do.

For example, the control device 110 may extract a peak of the biosignal after filtering the biosignal at about 1 to 30Hz, and measure the heart rate of the user based on the extracted peak. can decide For example, the control device 110 may detect and/or extract a peak of the biosignal frequency after filtering of about 0.1 to 2Hz for the biosignal, and the detected frequency And/or it is possible to determine the user's respiration rate based on the extracted peak. The operation of determining the user's heart rate and/or respiration rate is a technique already known in the prior art, and further detailed description will be omitted.

According to an embodiment, the control device 110 may control one or more components of the device 100 to allow a user to receive tinnitus treatment, and during the tinnitus treatment, the measurement module 150 and/or the The optical sensor 190 may be used to determine the heart rate and/or respiration rate of the user. The control device 110, in terms of the safety of the tinnitus treatment, when the user breathes excessively or the user's heart rate is rapidly changed (eg, the user's heart rate is changed to bradycardia), the tinnitus treatment may be discontinued. The control device 110 may perform a quantitative evaluation of the user's stress for the treatment of tinnitus using heart rate variability (HRV), which is one of chronic stress indicators.

For example, the control device 110 may control the measurement module during the output of the current stimulation through the one or more electrodes 141 of the stimulation module 150 and/or the output of the sound stimulation through the speaker 159 . The user's bio-signal may be detected through 150 and/or the optical sensor 190 , and the user's heart rate and/or respiration rate may be determined based on the detected bio-signal.

For example, the control device 110 checks whether the determined heart rate and/or respiration rate is out of a preset reference range (eg, a reference heart rate range and/or a reference respiratory rate range), and the determined heart rate and/or respiration rate When the number is out of the preset reference range, the output of the current stimulation through the one or more electrodes 141 of the stimulation module 150 and/or the output of the sound stimulation through the speaker 159 may be stopped.

For example, the control device 110 may check the user's heart rate variability based on the detected bio-signals, for example, ECG and PPG, and based on the confirmed heart rate variability, the user may receive treatment for tinnitus. It is possible to quantitatively evaluate the stress during receiving. For example, the control device 110 may digitize and output the stress based on a comparison result between the confirmed heart rate variability and a reference heart rate variability (also referred to as a threshold value).

Referring to (a) of FIG. 5 , the device for treating tinnitus (eg, the device 100 or the control device 110 of the device 100) is based on a preset condition and/or the result of previous tinnitus treatment. , it is possible to determine (set, change) the parameters of sound stimulation to be provided for the treatment of tinnitus. The parameters of the sound stimulus include a type of sound stimulus (tone, tone combination, white noise), a magnitude of the sound stimulus (Amp1), and/or an output time of the sound stimulus (eg, one output time) (d1). can do. For example, the apparatus for treating tinnitus determines the type of the sound stimulus as white noise, determines the amplitude (Amp1) of the sound stimulus as 90 dB SPL, and one output time (d1) of the sound stimulus. can be determined as 20 to 500 ms.

Referring to (b) of FIG. 5 , the device for treating tinnitus determines (set, change) parameters of current stimulation to be provided for tinnitus treatment based on preset conditions and/or results of previous tinnitus treatment can do. The parameters of the current stimulation are, the size of the current stimulation (Amp2), the width of the current stimulation (d2), the provision interval for each current stimulation (d3), and/or the output time of the current stimulation (eg, one output time) ) (d4). For example, the device for treating tinnitus determines the size of the current stimulation to be less than 5mA, determines the width (d2) of the current stimulation to be 5 to 200us, and provides an interval (d3) for each of the current stimulations It is determined as 2 to 50 ms, and one output time (d4) of the current stimulation may be determined to be 20 to 500 ms.

According to an embodiment, the sound stimulation and the current stimulation may consist of a sound and current stimulation pair, and the device for treating tinnitus is based on a preset condition and/or a result of a previous tinnitus treatment. , to determine (set, change) the interval between the sound and current stimulation pairs and the total stimulation time.

For example, the apparatus for treating tinnitus may determine the interval between the sound and current stimulation pairs to be 100 ms or less, and determine the initial value of the total stimulation time to be 30 minutes or more. For example, the device for treating tinnitus may determine the timing of output of sound and current stimulation in sound and current stimulation pairs.

The stimulation waveform provided for the treatment of tinnitus of FIG. 5 described above may be variously changed as shown in FIG. 6 to be described later as an example.

Referring to FIG. 6A , the parameters of the sound stimulation to be provided for the treatment of tinnitus may include an output waveform of the sound stimulation in the form of a sine wave including the amplitude of A1 and the period of F1. In addition, the parameters of the sound stimulus to be provided for the treatment of tinnitus include a preset output time (eg, one output time) (T1, T2) of the output waveform of the sound stimulus and output times (T1) of the output waveform of the sound stimulus , T2) may include a preset silent interval T2.

Referring to (b) of FIG. 6 , the parameters of the current stimulation for tinnitus treatment include an output delay time T4 that allows the current stimulation to be output after a preset time has elapsed after the output of the sound stimulation. can In addition, the parameters of the current stimulation for the treatment of tinnitus include a square wave having one cycle (P1) and a first waveform (61) including a rest time (P2) that does not output current stimulation and the first waveform ( 61) of the output time T5.

Referring to FIG. 7 , in operation 701 , the device for treating tinnitus (eg, the device 100 or the control device 110 of the device 100 ) may output a sound stimulus.

According to an embodiment, the device may output a pre-pulse interval method sound stimulus set in advance or generated according to the above-described embodiment through a speaker (eg, the speaker 159).

In operation 703, the device may detect the user's brain wave.

According to an embodiment, the device may detect the user's brain wave through one or more electrodes (eg, electrode 145 , electrode 147 , electrode 149 ). For example, the device may detect the brain wave of the user after or during the output of the sound stimulus.

In operation 705, the device may diagnose (determine) the user's tinnitus degree and tinnitus frequency.

According to an embodiment, the device may diagnose the degree of tinnitus and the frequency of tinnitus of the user based on the detected EEG.

For example, the device may extract preset features from the detected EEG, and diagnose the user's tinnitus degree and tinnitus frequency based on the extracted features. For example, the preset characteristics may include N1_amp (gap), Delta_rel_power, N1P2_ratio, Theta_rel_power, N1P2_auc (gap), Alpha_rel_power, Total_auc (gap), Beta_rel_power, Total_auc (nogap), and/or Gamma_rel_power. Since the operation of diagnosing the user's tinnitus degree and tinnitus frequency has been described above, a detailed description thereof will be omitted.

In operation 707, the device may output a stimulus for treating the user's tinnitus.

According to an embodiment, the device outputs a sound stimulus through the speaker and a current stimulus through one or more electrodes (eg, electrode 141 and electrode 143) based on the diagnosis of the tinnitus degree and tinnitus frequency. can do. Since the output operation of the sound stimulus and the current stimulus has been described above, a detailed description thereof will be omitted.

In operation 709, the device may determine whether the tinnitus treatment time exceeds a preset threshold time (N).

If the tinnitus treatment time exceeds a preset threshold time, operation 717 may be performed, otherwise operation 711 may be continued.

In operation 711, the device may check the user's respiration rate and heart rate.

According to an embodiment, the device may measure an electrocardiogram and a photoplethysmogram, and check a user's respiration rate and heart rate based on the measurements.

In operation 713, the device may determine whether a result value according to the check is out of a preset normal range (also referred to as a threshold range).

If the result value according to the check is out of the preset normal range, operation 715 may be performed, otherwise operation 707 may be continued.

In operation 715, the device may output information indicating that a result value according to the check is out of a normal range.

According to an embodiment, the device transmits the information to the display device and/or outputs the information as voice through a speaker of the device so that the information is visually output to a display device communicatively connected to the device can

After operation 715, the operation of the present embodiment may end.

In operation 717, the device may detect the user's brain wave.

According to an embodiment, the device may detect the user's brain waves through one or more electrodes (eg, the electrode 141 and the electrode 145 ).

In operation 719, the device may diagnose the user's tinnitus degree and tinnitus frequency.

In operation 721, the device may determine the effect of the tinnitus treatment.

According to an embodiment, the device may determine the effect of the tinnitus treatment based on the diagnosis of the degree of tinnitus and the frequency of tinnitus. For example, the device may compare the tinnitus degree and tinnitus frequency diagnosed in operation 705 with the tinnitus severity and tinnitus frequency diagnosed in operation 713 to determine the effectiveness of the tinnitus treatment. For example, the device may quantify and output the effect of the tinnitus treatment, and may determine the effect of the tinnitus treatment based on the value according to the numerical value.

7, the device further outputs visual information corresponding to the effect of the tinnitus treatment through a display device (not shown) of the device and/or an auditory device corresponding to the effect of the tinnitus treatment. The information can be output through the speaker of the device so that the user can confirm it.

Referring to FIG. 8 , in operation 801 , the device for treating tinnitus (eg, the device 100 or the control device 110 of the device 100 ) is first configured through a speaker (eg, the speaker 159 ) of the device. A sound stimulus can be output.

According to one embodiment, the device includes a first electrode (eg, a first electrode) that includes the speaker and an outlet formed so that sound stimulation through the speaker is output to the outside, and can be mounted on a part of the user's ear. (143)), a cable (eg, cable 123) electrically connected to the speaker and the first electrode, and one or more second electrodes (eg, a cable 123) positioned in at least a portion of the cable and electrically connected to the cable (eg: One or more second electrodes 145) may be included. For example, at least a portion of the cable in which the second electrode is located may be located in an auricular branch of vagus nerve portion in the ear or in-the-ear, ear canal portion or behind the auricle. (behind-the-ear) may include a predetermined portion to correspond to the scalp portion.

According to an embodiment, the first sound stimulus includes a first stimulus sound including a pulse noise and a first background noise and a second background sound having a silent gap between the pulse sound and the pulse sound. It may include a plurality of second stimulation sounds including.

In operation 803, the device may detect the user's brain wave through one or more second electrodes of the device, based on the output of the first sound stimulus.

According to an embodiment, the device generates a first waveform of the user's auditory evoked potential according to the first stimulus sound and a plurality of second waveforms of the user's auditory evoked potential according to the plurality of second stimulus sounds. can be detected.

In operation 805, the device may diagnose the user's tinnitus based on the detected EEG.

According to an embodiment, the apparatus calculates a plurality of gap prepulse inhibition (GPI) ratios that are ratios between the amplitudes between the poles of the first waveform and the amplitudes between the poles of the plurality of second waveforms to diagnose the tinnitus of the user can do.

In operation 807, the device may output a second sound stimulus through the speaker and a current stimulus through the first electrode of the device based on the result of the user's tinnitus diagnosis.

According to an embodiment, the device provides an output of the second sound stimulus and a response to the user's tinnitus diagnosis based on the pre-stored sound stimulation parameter and current stimulation parameter for each type of tinnitus and the result of the user's tinnitus diagnosis. It is possible to output the current stimulus.

In addition to the above-described embodiment of FIG. 8 , the device may further include an optical sensor (eg, the optical sensor 190 ). In addition, the device, while outputting the output of the second sound stimulus through the speaker and the current stimulus through the first electrode, the user's electrocardiogram (ECG) through the one or more second electrodes and measure the user's photoplethysmogram (PPG) using the optical sensor. In addition, the device checks the heart rate variability of the user based on the measured electrocardiogram and the measured photoplethysmography wave, and responds to the determined heart rate variability based on preset stress information for each heart rate variability to determine the user's stress. For example, the device may digitize and output the stress. In addition, the device determines the heart rate and respiration rate of the user based on the measured electrocardiogram and the measured photoplethysmogram wave, and when the determined heart rate and respiration rate exceed a preset threshold range, the The output of the second sound stimulus and the current stimulus through the first electrode may be controlled to stop or reduce the output.

In addition to the above-described embodiment, the device controls the output of the second sound stimulus and the output of the current stimulus to end based on a specified reference time, and after the end of the output, the output through the one or more second electrodes Effect of tinnitus treatment by re-detecting the user's EEG, re-performing the user's tinnitus diagnosis based on the re-detected EEG, and comparing the performed tinnitus diagnosis result with the re-performed tinnitus diagnosis result can be decided

Meanwhile, in the above embodiment, the first electrode (eg, the first electrode 143 ) and the second electrode (eg, one or more second electrodes 145 ) have been described as being separated from each other, but the device (eg, the device) 100) includes only one electrode, so that one electrode can output a current or voltage stimulus and detect a user's biosignal. For this operation, the device is configured as shown in FIG. may include.

Referring to FIG. 9 , the device 100 includes the components of FIG. 1 , for example, a control device 110 , a digital analog converter (DAC) 131 , a current stimulation circuit 133 , and a DAC. 135, an audio amplifier 137, a speaker 139, an optical sensor 190, an Analog Front-End 151, and/or an analog digital converter (ADC) 153. , each component may perform an operation corresponding to the component of FIG. 1 . The device 100 may include one electrode 141 instead of the first electrode 143 and the second electrode 145 of FIG. 1 . The device 100 may further include a switch 901 . The switch 901 allows the electrode 141 to detect a user's bio-signal (eg, a signal or impedance for recording an electrocardiogram) based on the control of the control device 110, so that the analog front- It can be switched to be connected to the end 151 or the electrode 151 to be connected to the current stimulation circuit 153 to output a current or voltage stimulation.

Accordingly, according to an embodiment of the present invention, the device 100 includes a speaker (eg, a speaker 139), one electrode and/or a cable (eg, a cable (eg, a cable) electrically connected to the speaker and the electrode. 123)) may be included. For example, the one electrode includes an outlet formed so that the first sound stimulus through the speaker of the device is output to the outside, has a shape that can be mounted on a part of the user's ear, and outputs a current or voltage stimulus, , a user's biosignal generated in response to the output of the first sound stimulus may be detected.

Referring to FIG. 2 , the one electrode in the embodiment of FIG. 9 may be the first electrode 143 or the second electrode 145 in FIG. 2 . Comparing the first electrode 143 and the second electrode 145 , the second electrode 145 is less effective than the first electrode 143 in providing a current or voltage stimulus to a user. However, the second electrode 145 may also provide current or voltage stimulation to the user. In detecting the user's biosignal, the first electrode 143 may be less effective than the second electrode 145 , but the first electrode 143 may also detect the user's biosignal. Accordingly, in consideration of the therapeutic aspect of the user's tinnitus, the device 100 may include the first electrode 143 as the single electrode.

10 and 11 , a binaural type device 1000 for personalized tinnitus treatment includes an electrode (eg, the first electrode 143 ) capable of outputting a current or voltage stimulus and a user's biosignal Two devices including one or more second electrodes (eg, one or more second electrodes 145 ) capable of detecting . Accordingly, it is possible to measure an EEG and an electrocardiogram including the user's auditory-induced response by a combination of the stimulation electrode and the left and right electrodes in the bi-ear form.

Referring to FIG. 10 , the apparatus 1000 may be implemented in a quantitative type. For example, as shown in FIG. 10 , the device 1000 may be implemented so that the user 1001 can wear it on both ears. Accordingly, the device 1000 may include a cable 1230 , a first device 100 - 1 , and a second device 100 - 2 .

The first device 100-1 includes a first structure 1400-1 including a 1-1 electrode 143-1 and a first reference electrode (not shown), and the 1-1 electrode 143. -1) may include a first cable 123-1 connected to a portion of the first cable 123-1, and one or more 2-1-th electrodes 145-1 positioned on at least a portion of the first cable 123-1. The one or more 2-1 th electrodes 145 - 1 may include a 3-1 th electrode 147 - 1 , a 4-1 th electrode 149 - 1 , and a fourth reference electrode 1113 .

The second device 100-2 includes a second structure 1400-2 including a 1-2 electrode 143-2 and a second reference electrode (not shown), and the 1-2 electrode 143. -2) may include a second cable 123-2 connected to a portion of the second cable 123-2, and one or more second-second electrodes 145-2 positioned at at least a portion of the second cable 123-2. The one or more 2-2 electrodes 145 - 2 may include a 3-2 electrode 147 - 2 , a 4 - 2 electrode 149 - 2 and a third reference electrode 1111 .

The 1-1 electrode 143-1 and the 1-2 electrode 143-2 correspond to the first electrode 143 of FIG. 2, respectively, and the first reference electrode and the second reference electrode are Each may correspond to the reference electrode 144 of FIG. 2 , and the first structure 1400-1 and the second structure 1400-2 may correspond to the structure 1400 of FIG. 2 , respectively. The first cable 123-1 and the second cable 123-2 may correspond to the cable 123 of FIG. 2, respectively. The one or more 2-1 th electrodes 145 - 1 and the one or more 2-2 nd electrodes 145 - 2 may correspond to the one or more second electrodes 145 of FIG. 2 . The 3-1 electrode 147 - 1 and the 3 - 2 electrode 147 - 2 may correspond to the third electrode 147 of FIG. 2 . The 4-1 th electrode 149 - 1 and the 4-2 th electrode 149 - 2 may correspond to the fourth electrode 149 of FIG. 2 .

The cable 1230 may be electrically connected to the first cable 123-1 of the first device 100-1, and may be electrically connected to the second cable 123-2 of the second device 100-2. It can be electrically connected.

On the other hand, the separation distance between the 3-1 electrode 147-1 and the 4-1 electrode 149-1, the 3-2 electrode 147-2 and the 4-2 electrode 149 -2) It may be more efficient to measure the biosignal by maintaining the separation distance as far as possible.

Referring to FIG. 11 , detailed configurations for measuring a user's biosignal included in the binaural-type device 1000 include a first measurement module 1100 , a second measurement module 1200 , and an electrocardiogram acquisition module ( 1300), 3-1 electrode 147-1, 4-1 electrode 149-1, 3-2 electrode 147-2, 4-2 electrode 149-2, third reference It may include an electrode 1111 and a fourth reference electrode 1113 .

The 3-1 th electrode 147-1, the 4-1 th electrode 149-1, and the third reference electrode 1111 may be used to measure a biosignal of the right ear. The 3-2 electrode 147 - 2 , the 4 - 2 electrode 149 - 2 , and the fourth reference electrode 1113 may be used to measure the biosignal of the left ear.

The first measurement module 1100 is a configuration for measuring the biosignal of the right ear, and can measure the potential difference between the 3-1 th electrode 147-1 and the 4-1 th electrode 149-1, An output signal may be extracted and output from the measured potential difference value. The first measurement module 1100 may include a signal processing device 523 for extracting the biosignal of the right ear from the potential difference between the 3-1 th electrode 147-1 and the 4-1 th electrode 149-1. can

The second measurement module 1200 is a configuration for measuring the biosignal of the left ear, and can measure the potential difference between the 3-2 th electrode 147-2 and the 4-2 th electrode 149-2, An output signal may be extracted and output from the measured potential difference value. The second measurement module 1200 may include a signal processing device 524 for extracting a biosignal of the right ear from the potential difference between the 3-2nd electrode 147-2 and the 4-2th electrode 149-2. can

Meanwhile, the apparatus 1000 includes a switch 1115 , a third reference electrode 1111 , and a fourth reference electrode 1113 , and according to a switching operation of the switch 1115 , the biosignal measurement of the right ear In this case, it may be connected to the third reference electrode 1111 , and when measuring the biosignal of the left ear, it may be connected to the fourth reference electrode 1113 .

Additionally, in order to acquire the user's ECG, the ECG acquisition module 1300 may measure a potential difference between the 3-1 th electrode 147-1 and the 3-2 th electrode 147-2, and A value of the measured potential difference may be output as an electrocardiogram output signal. 11 , it has been described that the third reference electrode 1111 or the fourth reference electrode 1113 is connected to the device 1000 according to the switching operation of the switch 1115 . In this configuration, a biosignal, which is a hearing-induced response of one ear of the user, may be individually measured. However, according to another embodiment, the third reference electrode 1111 or the fourth reference electrode 1113 is implemented as one reference electrode and the switch 1115 is excluded, so that the hearing-induced reaction of both ears is a living body. It is also possible to measure signals simultaneously.

Various embodiments of the present document include instructions stored in a machine-readable storage media (eg, memory 215 (internal memory or external memory)) that can be read by a machine (eg, a computer). It may be implemented in software (eg, a program). The device is a device capable of calling a stored command from a storage medium and operating according to the called command, and may include an electronic device (eg, the electronic device 200 ) according to the disclosed embodiments. When the instruction is executed by a processor (eg, the processor 201 ), the processor may directly or use other components under the control of the processor to perform a function corresponding to the instruction. Instructions may include code generated or executed by a compiler or interpreter. The device-readable storage medium may be provided in the form of a non-transitory storage medium. Here, 'non-transitory' means that the storage medium does not include a signal and is tangible, and does not distinguish that data is semi-permanently or temporarily stored in the storage medium.

According to an example, the method according to various embodiments disclosed in the present document may be included and provided in a computer program product.

The above description is merely illustrative of the technical idea of the present invention, and those of ordinary skill in the art to which the present invention pertains may make various substitutions, modifications, and changes within the scope not departing from the essential characteristics of the present invention. It will be easy to see that this is possible. That is, the embodiments disclosed in the present invention are not intended to limit the technical spirit of the present invention, but to explain, and the scope of the technical spirit of the present invention is not limited by these embodiments.

Accordingly, the protection scope of the present invention should be interpreted by the claims described below, and all technical ideas within the scope equivalent thereto should be interpreted as being included in the scope of the present invention.

The present invention can be used for diagnosis and treatment of tinnitus in the medical field.

Claims

In the device for personalized tinnitus treatment,

speaker;

a first electrode including an outlet formed so that the first sound stimulus through the speaker is output to the outside and having a shape that can be mounted on a part of the user's ear and capable of outputting a current or voltage stimulus; and

at least one second electrode for detecting a user's biosignal generated in response to the output of the first sound stimulus, and a control device for controlling the first electrode and the second electrode,

The control device is

Based on the detected bio-signal, tinnitus diagnosis is performed on the user,

Control to output a second sound stimulus output through the speaker and a current stimulus through the first electrode based on the result of tinnitus diagnosis for the user,

Personalized tinnitus that controls the output of the second sound stimulus and the output of the current stimulus through the first electrode based on the pre-stored sound stimulus parameter and current stimulus parameter for each tinnitus type and the result of the user's tinnitus diagnosis device for treatment.
The method of claim 1,

Further comprising a cable electrically connected to the speaker and the first electrode,

wherein the one or more second electrodes are positioned on at least a portion of the cable and electrically connected to the cable, and wherein the control device is electrically connected to the cable;

A device for personalized tinnitus treatment.
3. The method of claim 2, wherein at least a portion of the cable on which the one or more second electrodes are located comprises:

Including a portion predetermined to correspond to a portion of the auricular branch of vagus nerve in the ear or an in-the-ear, ear canal portion or a portion of the scalp behind the auricle A device for personalized tinnitus treatment.
The method of claim 1,

The user's bio-signal is a device for personalized tinnitus treatment including the user's brain waves.
3. The method of claim 2,

different speakers;

a first additional electrode including an outlet formed to output the first sound stimulus through the other speaker to the outside and having a shape that can be mounted on a part of the user's ear and capable of outputting a current or voltage stimulus;

another cable electrically connected to the other speaker and the first additional electrode; and

One or more second additional electrodes positioned on at least a portion of the other cable and electrically connected to the other cable for detecting a user's biosignal generated in response to the output of the first sound stimulus,

The other cable is electrically connected to the control device, a device for personalized tinnitus treatment.
According to claim 1, wherein the first sound stimulus,

Personalization including a plurality of second stimulus sounds including a first stimulus sound including a pulse noise and a first background noise and a second background sound having a pulse sound and a silent gap Device for the treatment of tinnitus.
According to claim 6, wherein the control device,

detecting a first waveform of the user's auditory evoked potential according to the first stimulus sound and a plurality of second waveforms of the user's auditory evoked potential according to the plurality of second stimulus sounds;

An apparatus for diagnosing the user's tinnitus by calculating a plurality of gap prepulse inhibition (GPI) ratios that are ratios between the amplitudes between the poles of the first waveform and the amplitudes between the poles of the plurality of second waveforms.
In the device for personalized tinnitus treatment,

speaker;

a first electrode including an outlet formed so that the first sound stimulus through the speaker is output to the outside and having a shape that can be mounted on a part of the user's ear and capable of outputting a current or voltage stimulus; and

one or more second electrodes for detecting a user's biosignal generated in response to the output of the first sound stimulus,

The biosignal is a device for personalized tinnitus treatment including a signal for recording an electrocardiogram.
9. The method of claim 8,

a control device for controlling the first electrode and the second electrode; and an optical sensor,

The control device is

diagnosing the tinnitus of the user based on the detected biosignal, and outputting a second sound stimulus through the speaker and a current stimulus through the first electrode based on a result of the user's tinnitus diagnosis control,

While outputting the second sound stimulus through the speaker and outputting the current stimulus through the first electrode, the user's electrocardiogram (ECG) is measured through the at least one second electrode, and the optical sensor A device for personalized tinnitus treatment that measures the user's photoplethysmogram (PPG) using
10. The method of claim 9, wherein the control device,

checking the heart rate variability of the user based on the measured electrocardiogram and the measured photoplethysmography wave, and determining the stress value of the user based on the determined heart rate variability and corresponding stress information for each preset heart rate variability Device for personalized tinnitus treatment
10. The method of claim 9, wherein the control device,

The heart rate and respiration rate of the user are determined based on the measured electrocardiogram and the measured photoplethysmogram wave, and when the determined heart rate and respiration rate exceed a preset threshold range, the second sound stimulus is output through the speaker and a device for personalized tinnitus treatment for controlling to stop or reduce the output of the current stimulation through the first electrode.
10. The method of claim 9,

The control device controls to end the output of the second sound stimulus and the output of the current stimulus through the first electrode based on a specified reference time, and the output of the second sound stimulus and the current through the first electrode After the output of the stimulus is finished, the user's bio-signals are re-detected through the one or more second electrodes,

Based on the re-detected biosignal, the tinnitus diagnosis for the user is re-performed, and the result of the performed tinnitus diagnosis is compared with the result of the re-performed tinnitus diagnosis to determine the degree of effectiveness of the tinnitus treatment. Device for the treatment of tinnitus.
As a computer-readable recording medium storing a computer program,

The computer program, when executed by a processor,

outputting a first sound stimulus through a speaker of the device;

detecting a user's biosignal generated in response to an output of the first sound stimulus through a detection electrode of the device;

performing tinnitus diagnosis on the user based on the EEG included in the detected biosignal; and

and outputting a second sound stimulus through the speaker and a current stimulus through one or more current stimulus applying electrodes of the device based on a result of tinnitus diagnosis for the user, wherein the biosignal records the electrocardiogram A computer-readable recording medium comprising instructions for causing the processor to perform a method further comprising a signal for performing a method.