WO2021099466A2 - Auricular neurostimulation device, system and associated method - Google Patents

Auricular neurostimulation device, system and associated method Download PDF

Info

Publication number
WO2021099466A2
WO2021099466A2 PCT/EP2020/082688 EP2020082688W WO2021099466A2 WO 2021099466 A2 WO2021099466 A2 WO 2021099466A2 EP 2020082688 W EP2020082688 W EP 2020082688W WO 2021099466 A2 WO2021099466 A2 WO 2021099466A2
Authority
WO
WIPO (PCT)
Prior art keywords
stimulation
user
auricular
neurostimulation
ear
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2020/082688
Other languages
English (en)
French (fr)
Other versions
WO2021099466A3 (en
Inventor
Iñaki LARRAYA
Miguel LOPEZ FERNANDEZ
Pedro Emilio BERMEJO
Miguel GARCIA DE GURTUBAY
Alberto FARRE
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Walden Medical Neuro Digital Therapies SL
Original Assignee
Walden Medical Neuro Digital Therapies SL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Walden Medical Neuro Digital Therapies SL filed Critical Walden Medical Neuro Digital Therapies SL
Priority to EP20888824.8A priority Critical patent/EP4061472B1/en
Priority to JP2022529572A priority patent/JP7777073B2/ja
Priority to KR1020227019382A priority patent/KR20220104189A/ko
Priority to AU2020387106A priority patent/AU2020387106A1/en
Priority to ES20888824T priority patent/ES2986739T3/es
Priority to CA3162170A priority patent/CA3162170A1/en
Priority to US17/778,348 priority patent/US20230026037A1/en
Priority to CN202080080686.3A priority patent/CN114980956A/zh
Publication of WO2021099466A2 publication Critical patent/WO2021099466A2/en
Publication of WO2021099466A3 publication Critical patent/WO2021099466A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/36036—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation of the outer, middle or inner ear
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/3606—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for a particular treatment
    • A61N1/3611—Respiration control
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/01—Measuring temperature of body parts ; Diagnostic temperature sensing, e.g. for malignant or inflamed tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording for evaluating the cardiovascular system, e.g. pulse, heart rate, blood pressure or blood flow
    • A61B5/024—Measuring pulse rate or heart rate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording for evaluating the cardiovascular system, e.g. pulse, heart rate, blood pressure or blood flow
    • A61B5/024—Measuring pulse rate or heart rate
    • A61B5/02405—Determining heart rate variability
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording for evaluating the cardiovascular system, e.g. pulse, heart rate, blood pressure or blood flow
    • A61B5/026—Measuring blood flow
    • A61B5/0261—Measuring blood flow using optical means, e.g. infrared light
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/08—Measuring devices for evaluating the respiratory organs
    • A61B5/0803—Recording apparatus specially adapted therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
    • A61B5/14551—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6801—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
    • A61B5/6813—Specially adapted to be attached to a specific body part
    • A61B5/6814—Head
    • A61B5/6815—Ear
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M21/00—Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/0404—Electrodes for external use
    • A61N1/0408—Use-related aspects
    • A61N1/0456—Specially adapted for transcutaneous electrical nerve stimulation [TENS]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/0404—Electrodes for external use
    • A61N1/0472—Structure-related aspects
    • A61N1/0476—Array electrodes (including any electrode arrangement with more than one electrode for at least one of the polarities)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/36003—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation of motor muscles, e.g. for walking assistance
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3601—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation of respiratory organs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/36014—External stimulators, e.g. with patch electrodes
    • A61N1/36021—External stimulators, e.g. with patch electrodes for treatment of pain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/36014—External stimulators, e.g. with patch electrodes
    • A61N1/36025—External stimulators, e.g. with patch electrodes for treating a mental or cerebral condition
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/36014—External stimulators, e.g. with patch electrodes
    • A61N1/3603—Control systems
    • A61N1/36031—Control systems using physiological parameters for adjustment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/36014—External stimulators, e.g. with patch electrodes
    • A61N1/3603—Control systems
    • A61N1/36034—Control systems specified by the stimulation parameters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/3606—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for a particular treatment
    • A61N1/36114—Cardiac control, e.g. by vagal stimulation
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H20/00—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance
    • G16H20/30—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to physical therapies or activities, e.g. physiotherapy, acupressure or exercising
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M21/00—Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis
    • A61M2021/0005—Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis by the use of a particular sense, or stimulus
    • A61M2021/0072—Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis by the use of a particular sense, or stimulus with application of electrical currents

Definitions

  • VNS is a novel strategy that has demonstrated efficacy to treat inflammatory conditions and has been hypothesized to prevent the chronic pro-inflammatory condition in elite athletes.
  • VNS increases levels of the anti-inflammatory cytokine IL-10 and decreases others such as the pro-inflammatory cytokines such as TNF-a, IL-1 b, and IL-6.
  • pro-inflammatory cytokines such as TNF-a, IL-1 b, and IL-6.
  • the reduced feed conversion efficiency associated with VNS may be mediated by hypothalamic BDNF, down-regulation of endocannabinoid tone in mesenteric adipose tissue and a PPARa- dependent increase in fatty acid oxidation in the liver, which in concerted action may account for the anorexic effect and increased energy expenditure.
  • an object of the present invention is to provide, according to a first aspect, an auricular neurostimulation device configured as an wireless earbud or auricular wearable by a user and configured to stimulate the Auricular Branch of Vagus Nerve (ABVN) on the user’s ear; the device comprising at least one electrode designed to be located in the cymba and another electrode in the cavum conchae.
  • the cymba electrode uses the entire area of the cymba to stimulate the ABVN present in the zone when a voltage difference is applied to it with respect to the cavum conchae electrode.
  • the auricular neurostimulation system of the invention further comprises a smartphone application that allows the user to interact with the neurostimulator.
  • Charging case 13 The auricular neurostimulation device 1 is stored when not used in a case 13 that charges its battery 10 wirelessly by electromagnetic induction. The device 1 discharges into this case 13 the data captured by the photoplethysmographic or biosensor 5 during stimulation when in use and sends them to a dedicated platform in the external cloud 15.
  • Protocols BFS that establish guidelines for the user to accommodate his breathing rhythm.
  • a central circuit 7 that controls all the functioning of the device, including the communication with the smartphone and the charger case, the generation of the stimulation patterns and the adjustment of the electrical voltage difference applied to the electrodes 2 and 3, according to the skin-electrode contact impedance.
  • cathodic stimulation (the stimulation pulse is negative) is 3 to 7 times more effective than anodic stimulation and the addition of a delay between the stimulation pulse and the reversal pulse reduces tissue damage and improves the effectiveness of the stimulation.
  • the device 1 can execute BSF or EVAN protocols, in which stimulation is synchronized with the user's exhalation, thus enhancing parasympathetic activation.
  • NTS Nucleus Tractus Solitarii
  • NTS receives inhibitory inputs from ventral respiratory nuclei in the medulla, reducing vagal outflow to the heart that could lead to respiratory sinus arrhythmia (RSA).
  • RSA respiratory sinus arrhythmia
  • the user creates an account on the system using the application for the smartphone or the web. For the registration, the user is asked for a series of personal data.
  • the photoplethysmographic or biosensor 5 stores temperature, hemoglobin and oxyhemoglobin readings of the user.
  • An algorithm analyses all the data to optimize the dose of electrical charge required by each user. If it is decided to change it, the platform sends the new values to the application so that the next stimulation is done with these newly modified values.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Physics & Mathematics (AREA)
  • Medical Informatics (AREA)
  • Physiology (AREA)
  • Surgery (AREA)
  • Molecular Biology (AREA)
  • Pathology (AREA)
  • Cardiology (AREA)
  • Neurology (AREA)
  • Otolaryngology (AREA)
  • Psychology (AREA)
  • Pulmonology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Social Psychology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Developmental Disabilities (AREA)
  • Hematology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Neurosurgery (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Optics & Photonics (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Acoustics & Sound (AREA)
  • Primary Health Care (AREA)
  • Epidemiology (AREA)
  • Electrotherapy Devices (AREA)
PCT/EP2020/082688 2019-11-20 2020-11-19 Auricular neurostimulation device, system and associated method Ceased WO2021099466A2 (en)

Priority Applications (8)

Application Number Priority Date Filing Date Title
EP20888824.8A EP4061472B1 (en) 2019-11-20 2020-11-19 Auricular neurostimulation device and system, and method of configuration of such a system
JP2022529572A JP7777073B2 (ja) 2019-11-20 2020-11-19 耳介神経刺激装置、システム及び関連する方法
KR1020227019382A KR20220104189A (ko) 2019-11-20 2020-11-19 귀 신경 자극 장치, 시스템 및 관련 방법
AU2020387106A AU2020387106A1 (en) 2019-11-20 2020-11-19 Auricular neurostimulation device and system
ES20888824T ES2986739T3 (es) 2019-11-20 2020-11-19 Dispositivo de neuroestimulación auricular, sistema y método asociado
CA3162170A CA3162170A1 (en) 2019-11-20 2020-11-19 Auricular neurostimulation device and system
US17/778,348 US20230026037A1 (en) 2019-11-20 2020-11-19 Auricular neurostimulation device and system
CN202080080686.3A CN114980956A (zh) 2019-11-20 2020-11-19 耳神经刺激装置及系统

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP19383020.5 2019-11-20
EP19383020.5A EP3693053B1 (en) 2019-11-20 2019-11-20 Auricular neurostimulation device and system

Publications (2)

Publication Number Publication Date
WO2021099466A2 true WO2021099466A2 (en) 2021-05-27
WO2021099466A3 WO2021099466A3 (en) 2022-03-17

Family

ID=68808227

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2020/082688 Ceased WO2021099466A2 (en) 2019-11-20 2020-11-19 Auricular neurostimulation device, system and associated method

Country Status (13)

Country Link
US (1) US20230026037A1 (https=)
EP (2) EP3693053B1 (https=)
JP (1) JP7777073B2 (https=)
KR (1) KR20220104189A (https=)
CN (1) CN114980956A (https=)
AU (1) AU2020387106A1 (https=)
CA (1) CA3162170A1 (https=)
DK (1) DK3693053T3 (https=)
ES (2) ES2908418T3 (https=)
PL (1) PL3693053T3 (https=)
PT (1) PT3693053T (https=)
SM (1) SMT202200123T1 (https=)
WO (1) WO2021099466A2 (https=)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023023707A1 (en) * 2021-08-21 2023-03-02 Mcfarlane Wade A closed loop control in-ear wearable electroceutical
WO2023059760A1 (en) * 2021-10-08 2023-04-13 Washington University Systems and methods for reducing inflammation in the central nervous system
JP2025513867A (ja) * 2022-05-20 2025-04-30 ニューリーヴ カンパニー リミテッド インピーダンス測定を反映した迷走神経に対する電気刺激印加方法及び迷走神経刺激装置

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2613987B (en) * 2020-10-07 2025-03-12 Well Being Digital Ltd Earplug comprising heat detector and pulse monitor and method of monitoring subject of his body heat
EP4243920B1 (en) * 2020-11-10 2026-04-15 The Alfred E. Mann Foundation for Scientific Research A stimulation system including a multi-electrode ear shell
KR20230160312A (ko) * 2021-03-24 2023-11-23 티니테크 엘티디 이명을 치료하기 위한 통합된 화학적 물리적 시스템(integrated chemical-physical system for treating tinnitus)
WO2022221644A2 (en) 2021-04-16 2022-10-20 Texas Medical Center Systems and methods for stimulating two or more nerve branches
WO2023119276A1 (en) * 2021-12-20 2023-06-29 Cogniguard Medical Holdings Limited Electrode configuration and method for auricular vagal nerve stimulation
US20230364413A1 (en) * 2022-05-13 2023-11-16 Electrocore, Inc. Systems and methods for optimizing nerve stimulation
CO2022015061A1 (es) * 2022-10-21 2023-02-06 Fund Cardiovascular De Colombia Dispositivo portátil de electroestimulación del nervio vago sincronizado con el ciclo respiratorio
WO2024093757A1 (en) * 2022-10-31 2024-05-10 Ko Wai Kin Daniel Neurostimulation device and system for transcutaneous auricular branch vagus nerve stimulation
USD1084366S1 (en) * 2023-04-05 2025-07-15 Wai Kin Daniel Ko Medical device
US12029893B1 (en) * 2023-06-14 2024-07-09 Spark Biomedical, Inc. Wearable auricular neurostimulator and methods of use
CN117504129A (zh) * 2023-11-20 2024-02-06 浙江强脑科技有限公司 刺激耳迷走神经的食欲控制方法、装置、设备及存储介质
WO2025127179A1 (ko) * 2023-12-12 2025-06-19 주식회사 뉴라이브 미주신경 자극장치
EP4578487A1 (en) 2023-12-28 2025-07-02 Xana Stim Sárl A system for bilateral auricular nerve stimulation of the vagus nerve
WO2025170001A1 (ja) * 2024-02-06 2025-08-14 国立大学法人北海道大学 間質性肺炎治療装置、間質性肺炎治療システム、間質性肺炎治療方法、間質性肺炎の症状の検出を補助する方法および装置の間質性肺炎の治療のための使用
WO2025219826A1 (en) * 2024-04-15 2025-10-23 Universita' Degli Studi Di Milano System for the transcutaneous auricular vagus nerve stimulation
CN121646490A (zh) * 2024-07-05 2026-03-10 韩国烟草人参公社 电刺激装置以及利用其的电刺激方法
CN119908672A (zh) * 2025-04-02 2025-05-02 上海爱楷医疗科技有限公司 一种经皮神经场迷走神经刺激诊疗设备及其诊疗方法

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20120035680A1 (en) 2009-04-03 2012-02-09 Vitaly Napadow Systems and Methods for Respiratory-Gated Auricular Vagal Afferent Nerve Stimulation
EP3100764A1 (de) 2015-06-03 2016-12-07 cerboMed GmbH Vorrichtung zur aufbringung eines transkutanen elektrischen stimulationsreizes
WO2019005774A1 (en) 2017-06-26 2019-01-03 Vorso Corp. DEVICE FOR STIMULATING PERIPHERAL NERVE TO MODIFY PARASYMPATHIC AND SYMPATHETIC ACTIVITY TO OBTAIN THERAPEUTIC EFFECTS
WO2019014250A1 (en) 2017-07-11 2019-01-17 The General Hospital Corporation SYSTEMS AND METHODS FOR NERVOUS STIMULATION WITH RESPIRATORY SYNCHRONIZATION

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE435679B (sv) * 1980-09-17 1984-10-15 Landskrona Finans Ab Stimulatorsystem, innefattande en av ett uppladdningsbart batteri driven pulsgenerator
US6418230B1 (en) * 1998-11-20 2002-07-09 Gn Netcom/Unex Inc. Flexible earhook
KR100553516B1 (ko) 2002-06-24 2006-02-20 정종필 알파파유도 전기자극기
US20080091255A1 (en) * 2006-10-11 2008-04-17 Cardiac Pacemakers Implantable neurostimulator for modulating cardiovascular function
WO2010087862A1 (en) 2009-02-02 2010-08-05 Victhom Human Bionics Inc. A method and device for the prevention of sudden unexpected death in epilepsy (sudep)
DE202010014951U1 (de) 2010-05-28 2011-11-25 Cerbomed Gmbh Elektrodenanordnung
WO2012167234A1 (en) * 2011-06-02 2012-12-06 Cedars-Sinai Medical Center Earphones and hearing aids
DE102013011530B3 (de) * 2013-07-10 2014-10-16 Cerbomed Gmbh Stimulationsvorrichtung
DE102013021175B4 (de) * 2013-12-17 2015-10-22 Cerbomed Gmbh Vorrichtung zur Aufbringung eines transkutanen elektrischen Stimulationsreizes
WO2015131093A1 (en) * 2014-02-27 2015-09-03 Thync, Inc. Methods and apparatuses for user control of neurostimulation
US10130809B2 (en) * 2014-06-13 2018-11-20 Nervana, LLC Transcutaneous electrostimulator and methods for electric stimulation
US11364380B2 (en) 2015-03-27 2022-06-21 Elwha Llc Nerve stimulation system, subsystem, headset, and earpiece
WO2016176668A1 (en) 2015-04-30 2016-11-03 Somtek, Inc. Breathing disorder detection and treatment device and methods
CN204814404U (zh) * 2015-08-14 2015-12-02 佛山博智医疗科技有限公司 耳鸣治疗装置
US10603482B2 (en) * 2015-09-23 2020-03-31 Cala Health, Inc. Systems and methods for peripheral nerve stimulation in the finger or hand to treat hand tremors
DE102015012684A1 (de) * 2015-09-30 2017-03-30 Cerbomed Gmbh Stimulationsvorrichtung
EP3405255B1 (en) * 2016-01-20 2025-12-31 Setpoint Medical Corporation IMPLANTABLE MICROSTIMULATORS AND INDUCTION CHARGING SYSTEMS
DK3238616T3 (en) * 2016-04-26 2019-04-01 Oticon As HEARING DEVICE CONTAINING ELECTRODES TO COLLECT A PHYSIOLOGICAL REACTION
EP3493031A4 (en) 2016-07-27 2019-08-14 Sony Corporation INFORMATION PROCESSING SYSTEM, RECORDING MEDIA AND INFORMATION PROCESSING METHOD
US10441786B2 (en) 2017-04-27 2019-10-15 Medtronic Xomed, Inc. System and method for stimulating a nerve
US12029901B2 (en) * 2017-06-30 2024-07-09 Lungpacer Medical Inc. Devices and methods for prevention, moderation, and/or treatment of cognitive injury
CA3071665A1 (en) * 2017-07-31 2019-02-07 The Feinstein Institutes For Medical Research Auricular stimulation device
US20190122757A1 (en) * 2017-10-22 2019-04-25 Rui Lin Method and device for software-defined therapy
WO2019143790A1 (en) * 2018-01-17 2019-07-25 Cala Health, Inc. Systems and methods for treating inflammatory bowel disease through peripheral nerve stimulation
CN109718470A (zh) * 2019-01-25 2019-05-07 江西心之乐医疗科技有限公司 一种入耳式无创耳迷走神经刺激仪及其脉冲输出方法

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20120035680A1 (en) 2009-04-03 2012-02-09 Vitaly Napadow Systems and Methods for Respiratory-Gated Auricular Vagal Afferent Nerve Stimulation
EP3100764A1 (de) 2015-06-03 2016-12-07 cerboMed GmbH Vorrichtung zur aufbringung eines transkutanen elektrischen stimulationsreizes
WO2019005774A1 (en) 2017-06-26 2019-01-03 Vorso Corp. DEVICE FOR STIMULATING PERIPHERAL NERVE TO MODIFY PARASYMPATHIC AND SYMPATHETIC ACTIVITY TO OBTAIN THERAPEUTIC EFFECTS
WO2019014250A1 (en) 2017-07-11 2019-01-17 The General Hospital Corporation SYSTEMS AND METHODS FOR NERVOUS STIMULATION WITH RESPIRATORY SYNCHRONIZATION

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023023707A1 (en) * 2021-08-21 2023-03-02 Mcfarlane Wade A closed loop control in-ear wearable electroceutical
WO2023059760A1 (en) * 2021-10-08 2023-04-13 Washington University Systems and methods for reducing inflammation in the central nervous system
EP4412702A1 (en) 2021-10-08 2024-08-14 Washington University Systems and methods for reducing inflammation in the central nervous system
EP4412702A4 (en) * 2021-10-08 2025-05-07 Washington University SYSTEMS AND METHODS FOR REDUCING CENTRAL NERVOUS SYSTEM INFLAMMATION
JP2025513867A (ja) * 2022-05-20 2025-04-30 ニューリーヴ カンパニー リミテッド インピーダンス測定を反映した迷走神経に対する電気刺激印加方法及び迷走神経刺激装置
EP4506031A4 (en) * 2022-05-20 2025-07-30 Neurive Co Ltd Method for electrical stimulation of the vagus nerve by means of reflective impedance measurement and vagus nerve stimulation device

Also Published As

Publication number Publication date
EP3693053A1 (en) 2020-08-12
JP7777073B2 (ja) 2025-11-27
DK3693053T3 (da) 2022-03-21
ES2986739T3 (es) 2024-11-12
KR20220104189A (ko) 2022-07-26
AU2020387106A1 (en) 2022-06-02
PT3693053T (pt) 2022-03-25
WO2021099466A3 (en) 2022-03-17
PL3693053T3 (pl) 2022-07-18
US20230026037A1 (en) 2023-01-26
CA3162170A1 (en) 2021-05-27
EP3693053B1 (en) 2022-01-05
EP4061472B1 (en) 2024-07-24
JP2023503291A (ja) 2023-01-27
EP4061472A2 (en) 2022-09-28
SMT202200123T1 (it) 2022-05-12
ES2908418T3 (es) 2022-04-29
CN114980956A (zh) 2022-08-30
EP4061472C0 (en) 2024-07-24

Similar Documents

Publication Publication Date Title
EP4061472B1 (en) Auricular neurostimulation device and system, and method of configuration of such a system
JP7470160B2 (ja) 末梢神経刺激による心機能不全の治療のためのシステムおよび方法
US20240001120A1 (en) Systems and methods for respiratory-gated nerve stimulation
US20220266012A1 (en) Systems, methods and devices for peripheral neuromodulation
KR102612964B1 (ko) 심박 변이를 개선하기 위한 시스템들 및 방법들
EP2026874B1 (en) Vagus nerve stimulation system
CN113784748A (zh) 利用节律生物过程治疗疾病的可穿戴周围神经刺激
US20210370066A1 (en) Neuromodulation and/or neurostimulation system
CN120322271A (zh) 神经调节装置和方法
US20220409847A1 (en) Ear device and paired treatments involving nerve stimulation
IL281649B1 (en) Selective and non-intrusive bioelectronic control of blood pressure
WO2024093757A1 (en) Neurostimulation device and system for transcutaneous auricular branch vagus nerve stimulation

Legal Events

Date Code Title Description
ENP Entry into the national phase

Ref document number: 2022529572

Country of ref document: JP

Kind code of ref document: A

Ref document number: 3162170

Country of ref document: CA

ENP Entry into the national phase

Ref document number: 2020387106

Country of ref document: AU

Date of ref document: 20201119

Kind code of ref document: A

ENP Entry into the national phase

Ref document number: 20227019382

Country of ref document: KR

Kind code of ref document: A

NENP Non-entry into the national phase

Ref country code: DE

ENP Entry into the national phase

Ref document number: 2020888824

Country of ref document: EP

Effective date: 20220620

121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 20888824

Country of ref document: EP

Kind code of ref document: A2

WWR Wipo information: refused in national office

Ref document number: 1020227019382

Country of ref document: KR