WO2021075837A1 - Non-cytotoxic hydrophilic modifying coating agent, non-cytotoxic nonwoven fabric including same, and preparation method therefor - Google Patents

Abstract

The present invention relates to a hydrophilic modifying coating agent without cytotoxicity and a textile product hydrophilically modified using same and, more particularly, to a hydrophilic modifying coating agent suitable for hydrophilically modifying a product having a hydrophobic surface, for example, a hydrophobic nonwoven fabric, and to a non-cytotoxic nonwoven fabric prepared using same.

Description

Cell non-toxic hydrophilic modified coating agent, non-toxic non-woven fabric containing same, and manufacturing method thereof

The present invention relates to a product having a hydrophobic surface with little cytotoxicity, for example, a hydrophilic modified coating agent suitable for modifying a hydrophobic nonwoven fabric to be hydrophilic, and to a nonwoven fabric manufactured using the same.

Since the conventionally known nonwoven fabrics made of polyolefin materials such as polypropylene have strong hydrophobicity, there is a problem that their application as industrial nonwoven fabrics and hygiene products requiring hydrophilicity is very limited.

In particular, non-woven fabrics are used for hygiene products, for example, disposable absorbent products such as baby diapers, adult diapers for urinary incontinence, sanitary napkin for women, and panty liner. As the nonwoven fabric, most synthetic nonwoven fabrics are applied, and the synthetic nonwoven fabric is a nonwoven fabric made of a polyolefin material such as polyethylene and polypropylene. However, such hygiene products are required to have hydrophilicity, and since the nonwoven fabric made of polyolefin material is hydrophobic, it is applied after imparting hydrophilicity to the nonwoven fabric.

In order to solve this problem, a synthetic hydrophilic modified coating agent is applied to the nonwoven fabric, but when used on a surface in contact with the skin, the synthetic hydrophilic modified coating agent is not discharged and remains on the body. Moreover, the synthetic hydrophilic modified coating that has entered through the skin cell membrane has a risk of causing disorders in cells such as the brain, heart, liver, spleen, etc., traveling around the body through blood, and also has a problem that can cause atopic dermatitis.

Accordingly, there is a need to develop a hydrophilic modified coating agent that provides hydrophilicity to a product made of a hydrophobic material that is in direct contact with the human body, preferably a hydrophobic nonwoven fabric, and does not harm the human body.

The object of the present invention is to solve the problems of these nonwovens based on the background of the problems of the conventional nonwovens as described above, and its main purpose is to have an optimal composition and composition ratio with low cytotoxicity. To prepare a hydrophilic modified coating agent, and use it, to provide a non-toxic cell nonwoven fabric imparting hydrophilicity to the hydrophobic nonwoven fabric.

In order to solve the above problems, the non-toxic hydrophilic modified coating agent of the present invention includes sodium salt, maleic acid salt, phosphate and alcohol ether compounds.

As a preferred embodiment of the present invention, the cell non-toxic hydrophilic modified coating agent may include 15 to 20% by weight of sodium salt, 10 to 16% by weight of maleate, 2 to 8% by weight of phosphate, and the balance of alcohol ether compounds. .

As a preferred embodiment of the present invention, the sodium salt in the composition of the cell-free hydrophilic modified coating agent is octyl sodium sulfosuccinic acid (docusate sodium), sodium dodecylbenzenesulfonate, ammonium alpha-sulfo-omega-(nonylphenoxy ) Poly(oxy-1,2-ethanediyl), sulfobutanedioxane 1,4-bis(2-(C ₁ to C ₃ alkyl) (C ₄ to C ₈ alkyl) ester sodium salt, sodium taloate, It may contain at least one selected from sodium cocoate and sodium palm kernelate.

As a preferred embodiment of the present invention, the maleate in the composition of the non-toxic hydrophilic modified coating agent is bis(2-(C ₁ ~ C ₃ alkyl) (C ₄ ~ C ₈ alkyl) maleate, ethylene male anhydride It may include at least one selected from an acid copolymer and an isobutylene maleic anhydride copolymer.

As a preferred embodiment of the present invention, the phosphate in the composition of the non-toxic hydrophilic modified coating agent is poly(oxy-1,2-ethanediyl), polyoxyethylene nonyl phenyl ether phosphoric acid, polyoxyethylene nonyl phenyl ether phosphoric acid, phosphoric acid Tris(2-ethylhexyl)ester and (Z)-alpha-2-octadekenyl-omega-hydroxypoly(oxy-1,2-ethandyl)phosphate.

As a preferred embodiment of the present invention, the alcohol ether-based compound in the composition of the cell non-toxic hydrophilic modified coating agent includes at least one selected from dipropylene glycol monomethyl ether, polyvinyl ether, polyethylene glycol, and alcohol polyoxyethylene ether. can do.

As a preferred embodiment of the present invention, the cell-free hydrophilic modified coating agent may have a viscosity of 950 to 1,100 mPa.s measured according to ASTM D7042 standard test (20°C).

As a preferred embodiment of the present invention, a solution obtained by dissolving the cell non-toxic hydrophilic modified coating agent in water at a concentration of 10% by weight may have a pH of 5 to 8 (when analyzed at 20°C).

As a preferred embodiment of the present invention, the cell non-toxic hydrophilic modified coating agent may have a melting point of -2 to 2°C.

Another object of the present invention relates to a method of manufacturing a non-toxic non-woven fabric using the previously described cell non-toxic hydrophilic modified coating agent, the first step of preparing the non-woven fabric; A second step of coating part or all of the nonwoven fabric with a non-toxic hydrophilic modified coating agent; And a 3 step of thermally fixing the hydrophilic modified coating agent to the nonwoven fabric by heat treatment to modify the nonwoven fabric to be hydrophilic.

As a preferred embodiment of the present invention, the nonwoven fabric may include hydrophobic fibers.

As a preferred embodiment of the present invention, the hydrophobic fiber may be a polyolefin-based fiber including at least one selected from polyethylene fiber, polypropylene fiber, and propylene ethylene copolymer fiber.

As a preferred embodiment of the present invention, the hydrophobic fiber may have an average diameter of 1 to 50 μm.

Another object of the present invention relates to a non-woven non-woven fabric containing hydrophobic fibers, as a non-woven fabric in which part or all of the non-woven fabric containing hydrophobic fibers is modified with a hydrophilic non-woven fabric, wherein the cell-free hydrophilic modified coating agent is 0.1 to 3% by weight of the total weight of the nonwoven Can include.

As a preferred embodiment of the present invention, _{when measuring IC 50} according to the ISO 10993-5 method, the cell viability may be 70 to 100%.

In a preferred embodiment of the present invention, the nonwoven fabric may be a spunbond nonwoven fabric, a melt blown nonwoven fabric, an air-laid, wet-laid, or dry-laid nonwoven fabric.

The hydrophilic modified coating of the present invention does not have cytotoxicity, has excellent coating properties, and has low rewetability when hydrophilic modification of a fiber material product using this, is suitable for use in modifying a hydrophobic fiber product into a hydrophilic fiber. , In particular, it is suitable for application to products that come into direct contact with the skin.

Hereinafter, the present invention will be described in more detail.

The non-toxic hydrophilic modified coating agent of the present invention includes sodium salt, maleate, phosphate and alcohol ether compounds.

The sodium salt is octyl sodium sulfosuccinic acid (docusate sodium), sodium dodecylbenzenesulfonic acid, ammonium alpha-sulfo-omega-(nonylphenoxy)poly(oxy-1,2-ethandiyl), sulfobutanedioxane sulfobutane Dioxane 1,4-bis (2-(C ₁ ~ C ₃ alkyl) (C ₄ ~ C ₈ alkyl) ester sodium salt, sodium taloate, sodium cocoate and one or two selected from sodium palm kernelate It may contain the above, preferably octyl sodium sulfosuccinic acid (docusate sodium), sodium dodecylbenzenesulfonate, ammonium alpha-sulfo-omega-(nonylphenoxy)poly(oxy-1,2-ethandiyl) And sulfobutanedioxane sulfobutanedioxane 1,4-bis(2-(C ₁ to C ₃ alkyl) (C ₄ to C ₈ alkyl) ester sodium salt selected from one or more selected from, , More preferably ammonium alpha-sulfo-omega-(nonylphenoxy)poly(oxy-1,2-ethandiyl) and sulfobutanedioxane sulfobutanedioxane 1,4-bis(2-(C ₂ ~ C ₃ of Alkyl) hexyl) ester may include one or two or more selected from sodium salts.

And, the content of the sodium salt may include 15 to 20% by weight, preferably 16 to 18.5% by weight, more preferably 16.5 to 18.0% by weight of the total weight of the hydrophilic modified coating agent. At this time, if the sodium salt content is less than 15% by weight, there may be a problem that the pH of the modified coating agent is too low, and when it exceeds 20% by weight, the pH of the modified coating agent is rather increased, and after the nonwoven fabric is modified, rewetting is lowered Since there may be a problem, it is better to use it within the above range.

In the composition of the hydrophilic modified coating agent, the maleic acid salt is bis(2-(C ₁ ~ C ₃ alkyl) (C ₄ ~ C ₈ alkyl) maleate, ethylene maleic anhydride copolymer, and isobutylene maleic anhydride copolymer. It may include one or two or more selected, preferably bis (2- (C ₂ ~ C ₃ alkyl) (C ₅ ~ C ₇ alkyl) maleate and ethylene maleic anhydride copolymer 1 selected from the type or two types, may be more preferably used a (hexyl 2- (alkyl of C ₂ ~ C ₃₎₎ bis maleate.

In addition, the content of maleate may include 10 to 16% by weight, preferably 11.0 to 14.8% by weight, and more preferably 12.0 to 14.0% by weight, based on the total weight of the hydrophilic modified coating agent. At this time, if the maleate content is less than 10% by weight, there may be a problem that the hydrophilicity improvement effect of the modified nonwoven fabric is lowered, and if it exceeds 16% by weight, there may be a problem of increasing cytotoxicity, so it is recommended to use it within the above range. good.

Next, the phosphate in the composition of the hydrophilic modified coating agent is poly(oxy-1,2-ethanediyl), polyoxyethylene nonyl phenyl ether phosphoric acid, polyoxyethylene nonyl phenyl ether phosphoric acid, phosphate tris(2-ethylhexyl) ester, ( Z)-alpha-2-octadekenyl-omega-hydroxypoly(oxy-1,2-ethandyl)phosphate and poly(oxy-1,2-ethaninyl), α-dodecyl-ω-hydroxy- , Phosphate, potassium salt (Poly(oxy-1,2-ethanediyl), α-dodecyl-ω-hydroxy-,phosphate, potassium salt/cas no. 58318-92-6} may include one or two or more selected from.

In addition, the content of phosphate may include 2 to 8% by weight, preferably 2.5 to 7.5% by weight, and more preferably 3.0 to 6.2% by weight, based on the total weight of the hydrophilic modified coating agent. At this time, if the phosphate content is less than 2% by weight, there may be a problem in that the durability absorption improvement effect of the modified nonwoven fabric is insufficient, and if it exceeds 8% by weight, there may be a problem that the durability absorption is rather lowered, so use within the above range. It is good to do.

Next, the alcohol ether compound in the composition of the hydrophilic modified coating agent serves as a solvent for the other compositions of the hydrophilic modified coating agent, and is selected from dipropylene glycol monomethyl ether, polyvinyl ether, polyethylene glycol and alcohol polyoxyethylene ether. One or two or more may be included, preferably one or two selected from dipropylene glycol monomethyl ether, polyvinyl ether and alcohol polyoxyethylene ether, more preferably dipropylene glycol monomethyl ether And alcohol polyoxyethylene ether.

In addition, the content of the alcohol ether compound is used in the remaining amount excluding other compositions of 100% by weight of the total hydrophilic modified coating agent.

The cell non-toxic hydrophilic modified coating agent of the present invention prepared by mixing the above-described compositions may have a viscosity of 950 to 1,100 mPa.s measured according to ASTM D7042 standard test (20°C), and preferably 980 to 1,080 mPa. s, more preferably 1,000 to 1,060 mPa.s.

In addition, the solution dissolved in water at a concentration of 9 to 12% by weight, preferably at a concentration of 10% by weight, of the cell non-toxic hydrophilic modified coating agent of the present invention has a pH of 5 to 8, preferably pH 5.5 when analyzed at 20°C. It may be ~ 7.5, more preferably a pH of 5.8 ~ 7.0.

In addition, the non-toxic hydrophilic modified coating agent of the present invention may have a melting point of -3 to 3°C, preferably a melting point of -2 to 2°C.

Hydrophobic products can be modified to be hydrophilic using the previously described cell non-toxic hydrophilic modified coating agent, and as a preferred example, description will be given of the hydrophilic modification of the nonwoven fabric as follows.

Step 1 of preparing a nonwoven fabric; A second step of coating part or all of the nonwoven fabric with a non-toxic hydrophilic modified coating agent; And 3 step of modifying the nonwoven fabric to be hydrophilic by thermally fixing the hydrophilic modified coating agent to the nonwoven fabric by heat treatment, thereby producing a hydrophilic modified nonwoven fabric.

The nonwoven fabric in step 1 may include hydrophobic fibers, some hydrophilic fibers may be included, or all nonwoven fabrics may be made of hydrophobic fibers. Some or all of the nonwoven fabric may have hydrophobicity.

The hydrophobic fiber may be a polyolefin-based fiber including at least one selected from polyethylene fiber, polypropylene fiber, and propylene ethylene copolymer fiber.

In addition, the hydrophobic fiber may have an average diameter of 1 μm to 50 μm, preferably 1 μm to 30 μm.

In addition, the nonwoven fabric of the first step may be a spunbond nonwoven fabric, a melt blown nonwoven fabric, an air-laid, a wet-laid, or a dry-laid nonwoven fabric.

Next, the cell non-toxic hydrophilic modified coating agent of step 2 is as described above. In addition, the coating of the second step may be performed by a general coating method used in the art, and preferably, it may be performed through a kiss roll coating method or a spray coating method.

Next, the heat treatment in the third step may be performed by applying heat of 100 to 150°C, preferably 110 to 140°C in a drum dryer. At this time, if the heat treatment temperature is less than 100°C, there may be a problem that drying of the nonwoven fabric is less, and if the heat treatment temperature exceeds 150°C, there may be a problem that the nonwoven fabric becomes hard.

The prepared hydrophilic modified non-woven fabric may contain a cell non-toxic hydrophilic modified coating agent in an amount of 0.1 to 3.0% by weight, preferably 0.4 to 2.8% by weight, and more preferably 0.5 to 1.5% by weight. At this time, if the content of the non-toxic hydrophilic modified coating agent is less than 0.1% by weight, the hydrophilicity modifying effect may be insufficient, and if it exceeds 3% by weight, the rewetability of the nonwoven fabric may increase and there may be a problem of moistening.

In addition, the cell-free non-woven fabric of step 3 may have a basis weight of 10 to 100 gsm.

In addition, the cell-free nonwoven fabric of the present invention may have a cell viability of 70 to 100%, preferably 85 to 100%, more preferably 90 to 100%, when _{IC 50 is measured according to the ISO 10993-5 method.}

In addition, the cellular non-toxic nonwoven fabric of the present invention is 2.50 to 3.50 seconds, preferably 2.50 to 3.20 seconds, when the liquid absorption rate is measured according to WSP 70.3(08) (Standard Test Method for Nonwoven Coverstock Liquid Strike-Through Time Using Simulated Urine). I can.

In addition, the cellular non-toxic nonwoven fabric of the present invention was measured for durability absorption according to WSP 70.7(09) (Standard Test Method for Nonwoven-Repeated Liquid Strike-Through Time), the first durability absorption was 1.50 to 2.80 seconds, and the second time Durable absorption is 2.00 to 3.50 seconds, and the third durability absorption may be 2.30 to 3.80 seconds.

In addition, the non-woven fabric of the present invention has a rewetability of 2.0 to 3.5 g, preferably 2.2 to when measuring the rewetability of a liquid according to WSP 70.8 (09) (Standard Test Method for Wetback After Repeated Strike-Through Time). May be 3.3g.

In addition, the cell-free nonwoven fabric of the present invention may have a cell viability of 70 to 100%, preferably 85 to 100%, more preferably 90 to 100%, when _{IC 50 is measured according to the ISO 10993-5 method.}

Hereinafter, the present invention will be described in more detail based on examples. The following examples are intended to aid understanding of the present invention, and should not be interpreted to limit the scope of the present invention by examples.

[Example]

Example 1: Preparation of cell non-toxic hydrophilic modified coating agent

Sodium salt sulfobutanedioxane 1,4-bis(2-ethylhexyl) ester sodium salt (cas no. 577-11-7), maleate bis(2-ethylhexyl) maleate (bis(2-ethylhexyl) maleate, cas no.142-16-5), phosphate poly(oxy-1,2-etheindinyl), α-dodecyl-ω-hydroxy-, phosphate, potassium salt (Poly(oxy-1,2- ethanediyl), α-dodecyl-ω-hydroxy-,phosphate, potassium salt/cas no. 58318-92-6) and dipropylene glycol monomethyl ether, an alcohol ether compound, are mixed and stirred to prepare a non-toxic hydrophilic modified coating agent. I did.

In addition, the contents of each of the sodium salt, maleic acid salt, phosphate and alcohol ether compounds in the hydrophilic modified coating agent are shown in Table 1 below.

Examples 2 to 7 and Comparative Examples 1 to 6

A hydrophilic modified coating agent was prepared in the same manner as in Example 1, but a hydrophilic modified coating agent having a composition and composition ratio as shown in Table 1 was prepared, respectively.

division (weight%)	Sodium salt	Maleate	phosphate	Alcohol ether compounds
Example 1	17.2	13.0	4.6	Remaining balance
Example 2	15.3	13.2	4.9	Remaining balance
Example 3	18.5	13.0	4.2	Remaining balance
Example 4	17.2	11.0	4.8	Remaining balance
Example 5	17.2	14.8	4.8	Remaining balance
Example 6	17.2	13.0	2.5	Remaining balance
Example 7	17.2	13.0	7.5	Remaining balance
Comparative Example 1	13.5	13.0	4.6	Remaining balance
Comparative Example 2	21.0	13.0	4.6	Remaining balance
Comparative Example 3	17.2	9.3	4.8	Remaining balance
Comparative Example 4	17.2	16.6	4.8	Remaining balance
Comparative Example 5	17.2	13.0	1.0	Remaining balance
Comparative Example 6	17.2	13.0	9.0	Remaining balance

Comparative Example 7

Isopropyl alcohol was prepared as a hydrophilic modified coating.

Comparative Example 8

A solution containing 20% by weight of a diester (Di-ester) and a remaining amount of a propylene glycol compound was prepared as a hydrophilic modified coating agent.

Comparative Example 9

A siloxane-based hydrophilic modified coating agent, CTFA (Dimethylsiloxane, 3-(3-((3-cocoamidopropyl)dimethylammonio)-2-hydroxyprpoxy)propyl groupterminated acetate / CAS 134737-05-6), was prepared as a hydrophilic modified coating agent.

Experimental Example 1: Measurement of viscosity and pH of a hydrophilic modified coating agent

The viscosity and pH of each of the hydrophilic modified coatings prepared in Examples 1 to 7 and Comparative Examples 1 to 9 were measured, and the results are shown in Table 2 below.

At this time, the viscosity was measured according to the ASTM D7042 standard test (20°C), and the pH was the pH of a solution in which a hydrophilic modified coating agent was dissolved in water at a concentration of 10% by weight, and analyzed at 20°C.

division	Viscosity (mPa.s)	pH	Melting point(℃)
Example 1	1,015 ~ 1,025	6.0 to 6.1	-1 to 1
Example 2	990 ~ 995	5.2 ~ 5.3	-1 to 1
Example 3	1,005 ~ 1,010	6.4 ~ 6.5	-1 to 1
Example 4	1,050 ~ 1,060	5.8 ~ 5.9	-1 to 1
Example 5	1,035 ~ 1,040	6.0 to 6.1	-1 to 1
Example 6	990 ~ 995	5.7 ~ 5.8	0 to 2
Example 7	1,080 ~ 1,085	6.2 ~ 6.3	-3 to -1
Comparative Example 1	980 ~ 985	4.5 ~ 4.6	-1 to 1
Comparative Example 2	1,070 ~ 1,075	7.4 ~ 7.5	-1 to 1
Comparative Example 3	985 ~ 990	6.5 ~ 6.7	-1 to 1
Comparative Example 4	1,095 ~ 1,100	5.7 ~ 5.8	-1 to 1
Comparative Example 5	975-980	5.7 ~ 5.8	3 to 5
Comparative Example 6	1,095 ~ 1,100	6.3 ~ 6.4	-3 to -1

Looking at the physical properties measurement results of the modified coating agent in Table 2, Examples 1 to 7 showed an appropriate range of properties ranging from viscosity 990 to 1,060 mPa.s, pH 5.2 to 6.3, and melting point -3°C to 1°C. On the other hand, sodium In the case of Comparative Example 1 in which the salt was used in an amount of less than 15% by weight, when compared with Examples 1 and 2, there was a problem that the pH was rapidly lowered and thus acidified, and in the case of Comparative Example 2 in which the sodium salt was used in excess of 20% by weight , When compared with Example 1 and Example 3, the pH showed a tendency to increase rapidly.

In addition, looking at the melting points of Examples 6 to 7 and Comparative Examples 5 to 6, it can be seen that the phosphate content affects the melting point of the modified coating agent.It was confirmed that the melting point of the modifying agent tends to increase when the amount of phosphate used decreases. In addition, Comparative Example 5 had the highest melting point, and when comparing Example 7 and Comparative Example 6, there was a tendency that there was no decrease in the melting point even when the phosphate was exceeded 8% by weight.

Preparation Example 1: Preparation of hydrophilic modified non-toxic non-woven fabric

A spunbond nonwoven fabric having a basis weight of 18 gsm made of polypropylene fibers having an average diameter of 17 μm was prepared (manufacturer Toray Advanced Materials, brand name LIVSEN).

Next, the hydrophilic modified coating agent prepared in Example 1 was coated and dried with a nonwoven fabric by a kiss roll coating method.

Next, heat treatment was performed in a drum dryer under a temperature condition of about 125 to 130° C. to prepare a non-woven fabric that was modified to be hydrophilic.

The content of the hydrophilic modified coating agent in the prepared non-toxic nonwoven fabric was about 0.7% by weight.

Preparation Examples 2 to 7 and Comparative Manufacturing 1 to 11

A nonwoven fabric having been modified to be hydrophilic in the same manner as in Preparation Example 1 was prepared, but each nonwoven fabric modified to be hydrophilic using each of the hydrophilic modified coating agents prepared in Examples 2 to 5 and Comparative Examples 1 to 9 instead of the hydrophilic modified coating agent of Example 1 To prepare, Preparation Examples 2 to 7 and Comparative Preparation Examples 1 to 11 were each performed as shown in Table 3 below.

division	Types of hydrophilic modified coatings	Content in non-woven fabric
Manufacturing Example 1	Example 1	0.7% by weight
Manufacturing Example 2	Example 1	0.4% by weight
Manufacturing Example 3	Example 1	2.6% by weight
Manufacturing Example 4	Example 2	0.7% by weight
Manufacturing Example 5	Example 3	0.7% by weight
Manufacturing Example 6	Example 4	0.7% by weight
Manufacturing Example 7	Example 5	0.7% by weight
Manufacturing Example 8	Example 6	0.7% by weight
Manufacturing Example 9	Example 7	0.7% by weight
Comparative Production Example 1	Example 1	0.08% by weight
Comparative Production Example 2	Example 1	3.1% by weight
Comparative Production Example 3	Comparative Example 1	0.7% by weight
Comparative Production Example 4	Comparative Example 2	0.7% by weight
Comparative Production Example 5	Comparative Example 3	0.7% by weight
Comparative Production Example 6	Comparative Example 4	0.7% by weight
Comparative Production Example 7	Comparative Example 5	0.7% by weight
Comparative Production Example 8	Comparative Example 6	0.7% by weight
Comparative Production Example 9	Comparative Example 7	0.7% by weight
Comparative Production Example 10	Comparative Example 8	0.7% by weight
Comparative Production Example 11	Comparative Example 9	0.7% by weight

Experimental Example 1: Evaluation of liquid absorption rate (strike through)

A measurement sample was prepared by cutting the nonwoven fabric prepared in Preparation Example and Comparative Preparation Example into a size of 10 cm x 10 cm (width x length).

Thereafter, the absorption rate of the measurement sample (specifically, the liquid absorption rate of the hydrophilic nonwoven layer) was measured according to WSP 70.3 (08) (Standard Test Method for Nonwoven Coverstock Liquid Strike-Through Time Using Simulated Urine), and the result It is shown in Table 4 below. After measuring the absorbance 10 times for the same type of measurement sample, the average value was recorded as the final absorption rate. Specifically, after placing the measurement sample on the absorbent paper, the time to absorb all 5 ml of 0.9 wt% NaCl aqueous solution through the absorbent paper was evaluated as the absorption rate.

Experimental Example 2: Evaluation of Durable Absorption

A measurement sample was prepared by cutting the nonwoven fabric prepared in Preparation Example and Comparative Preparation Example into a size of 10 cm x 10 cm (width x length).

Thereafter, the durability absorption of the measurement sample (specifically, the repeated absorption of the hydrophilic nonwoven layer) was measured according to WSP 70.7 (09) (Standard Test Method for Nonwoven-Repeated Liquid Strike-Through Time), and the results are as follows. It is shown in Table 4. Durable absorbency was measured three times for the same type of measurement sample, and then the durability absorbance was recorded. Specifically, after placing the measurement sample on the absorbent paper, the time to absorb a total of 15 ml of 5 ml of 0.9% by weight NaCl aqueous solution through the absorbent paper once, twice, and three times was evaluated for durable absorption, and the evaluation record is Recorded once, twice, and three times, respectively.

Experimental Example 3: Evaluation of rewetability (re-wet)

The rewetability of the measurement sample (specifically, hydrophilic nonwoven fabric) according to WSP 70.8(09) (Standard Test Method for Wetback After Repeated Strike-Through Time) using a measurement sample evaluating the absorption of liquid according to Experimental Example 1 The rewetability of the layer) was measured, and the results are shown in Table 4 below. Specifically, after placing the measurement sample for which the absorption of the liquid was evaluated according to Evaluation Example 1 on a new absorbent paper, 20 ml of a 0.9 wt% NaCl aqueous solution was added to the absorbent paper, and a load of 5 kg was applied to the measurement sample, and the measurement The amount of liquid reversely reabsorbed as a sample was measured and recorded as rewetability.

Experimental Example 4: Evaluation of cytotoxicity

_{Samples were collected from the nonwoven fabrics prepared in Preparation Example and Comparative Preparation Example, and IC 50} (inhibition concentration 50, colony formation inhibition) by the method of ISO 10993-5 (Biological evaluation of medical devices-Part 5: Tests for in-vitro cytotoxicity) Concentration) was analyzed, and the results are shown in Table 4 below. The IC ₅₀ evaluation result should be between 70 and 100% to be evaluated as a non-woven fabric.

division	Non-woven Basis weight (gsm)	absorption speed (sec)	Durability Absorption (sec)			Rewetability (g)	IC 50 (%)	Remark
			1 time	Episode 2	3rd time
Manufacturing Example 1	18	2.94	1.86	2.52	2.86	2.9	100	Cell nontoxic
Manufacturing Example 2	18	3.15	2.50	3.27	3.41	2.2	100	Cell nontoxic
Manufacturing Example 3	18	2.52	1.55	2.25	2.43	3.3	97	Cell nontoxic
Manufacturing Example 4	18	2.87	1.79	2.40	2.72	2.9	100	Cell nontoxic
Manufacturing Example 5	18	2.98	1.95	2.67	3.02	2.3	99	Cell nontoxic
Manufacturing Example 6	18	3.18	2.35	3.07	3.28	2.7	100	Cell nontoxic
Manufacturing Example 7	18	2.68	1.72	2.30	2.57	3.1	95	Cell nontoxic
Manufacturing Example 8	18	3.04	2.08	2.88	3.12	2.7	100	Cell nontoxic
Manufacturing Example 9	18	2.98	2.02	2.63	3.20	3.0	100	Cell nontoxic
Comparative Production Example 1	18	4.42	3.28	4.92	5.59	1.2	100	Cell nontoxic
Comparative Production Example 2	18	2.48	1.50	2.17	2.39	4.6	78	Moderate cytotoxicity
Comparative Production Example 3	18	2.85	1.72	2.46	2.78	2.8	100	Cell nontoxic
Comparative Production Example 4	18	3.05	2.09	2.98	3.10	1.7	100	Cell nontoxic
Comparative Production Example 5	18	3.86	2.77	3.46	3.828	2.7	100	Cell nontoxic
Comparative Production Example 6	18	2.36	1.52	1.98	2.21	3.2	81	Moderate cytotoxicity
Comparative Production Example 7	18	3.09	2.14	2.95	3.27	2.6	100	Cell nontoxic
Comparative Production Example 8	18	2.82	1.83	3.20	4.13	3.1	100	Cell nontoxic
Comparative Production Example 9	18	3.02	2.10	2.72	4.40	3.8	39.7	Medium Cytotoxicity
Comparative Production Example 10	18	2.54	1.61	2.45	2.43	4.5	16.4	Medium Cytotoxicity
Comparative Production Example 11	18	2.91	2.90	2.64	3.16	4.2	68.5	Moderate cytotoxicity

Looking at the measurement results of the physical properties in Table 4, in the case of Preparation Examples 1 to 9, the nonwoven fabric made of hydrophobic fibers was modified to be hydrophilic, so that the fast liquid absorption rate, durability against repeated absorption (durable absorption), and rewetability were excellent. On the other hand, in the case of Comparative Production Example 1 using less than 0.1% by weight of the hydrophilic modified coating agent, compared with Preparation Examples 1 and 2, there was almost no hydrophilic modification effect, so absorption rate and durability Absorption and refoldability showed very poor results. In addition, in the case of Comparative Production Example 2 in which the hydrophilic modified coating agent was used in excess of 3.0% by weight, the effect of increasing the hydrophilicity was weak, and the rewetability was too high, so that the nonwoven fabric was rather damp. Only the cytotoxicity was increased.

In the case of Preparation Example 3 using the modified coating agent of Example 2 and Preparation Example 4 using the modified coating agent of Example 4, compared to Preparation Example 1, there was no significant difference in terms of hydrophilic modification. On the other hand, in the case of Comparative Production Example 4 using the modified coating agent of Comparative Example 2, there was a problem in that the rewetability was greatly reduced as compared to Production Example 5.

In addition, in the case of Comparative Production Example 5 using the modified coating agent of Comparative Example 3, when compared to Preparation Example 6 (using Example 4), the hydrophilicity improvement effect was decreased, and Comparative Production using the modified coating agent of Comparative Example 4 In the case of Example 6, when compared with Preparation Example 1 and Preparation Example 7 (using Example 5), the hydrophilicity modification effect was excellent, but there was a problem that toxicity rapidly increased.

And, in the case of Comparative Production Example 7 using the modified coating agent of Comparative Example 5, as compared with Production Examples 1 and 8 (using Example 6), the effect of improving the absorption rate and durability absorption was insufficient. In addition, in the case of Comparative Production Example 8 using the modified coating agent of Comparative Example 6, when compared with Preparation Example 1 and Preparation Example 9 (using Example 7), there was no significant difference in the absorption rate, but the durable water absorption was greatly reduced, There was also a problem of increasing cytotoxicity.

Unlike the present invention without cytotoxicity (Preparation Examples 1 to 9), the existing hydrophilic modified coating agent isopropyl alcohol (Comparative Example 7), diester and propylene glycol mixture (Comparative Example 8) and CTFA (Comparative Example 9) hydrophilic In the case of the modified coated nonwoven fabric (Comparative Preparation Examples 9 to 11), the hydrophilicity was excellent, but it was confirmed that there is a problem of cytotoxicity.

Through the above Examples and Experimental Examples, it was confirmed that the hydrophilic modified coating agent of the present invention effectively modified hydrophobicity to hydrophilicity, and it was confirmed that there was no cytotoxicity. Such, by using the hydrophilic modified coating agent of the present invention is expected to be able to greatly expand the application range of the industrial nonwoven fabric and/or the nonwoven fabric for hygiene products, which had limited application uses.

The hydrophilic modified nonwoven fabric using the hydrophilic modified coating agent of the present invention can provide a variety of skin-friendly and nonwoven fabric products requiring hydrophilicity, such as industrial nonwoven fabric and/or nonwoven fabric for hygiene products.

Claims (10)

1. A non-toxic hydrophilic modified coating agent comprising sodium salt, maleic acid salt, phosphate and alcohol ether-based compounds.
2. The method of claim 1, wherein the sodium salt is octyl sodium sulfosuccinic acid (docusate sodium), sodium dodecylbenzenesulfonate, ammonium alpha-sulfo-omega-(nonylphenoxy)poly(oxy-1,2-ethandiyl) , Sulfobutanedioxane 1,4-bis(2-(C ₁ ~ C ₃ alkyl) (C ₄ ~ C ₈ alkyl) ester sodium salt, sodium taloate, sodium cocoate and one selected from sodium palm kernelate Cell non-toxic hydrophilic modified coating comprising the above.
3. The method of claim 1, wherein the maleic acid salt is bis(2-(C ₁ ~ C ₃ alkyl) (C ₄ ~ C ₈ alkyl) maleate, ethylene maleic anhydride copolymer, and isobutylene maleic anhydride copolymer. , Cell non-toxic hydrophilic modified coating comprising at least one selected from ethylene maleic anhydride copolymer and isobutylene maleic anhydride copolymer.
4. The method of claim 1, wherein the phosphate is poly(oxy-1,2-ethanediyl), polyoxyethylene nonyl phenyl ether phosphoric acid, polyoxyethylene nonyl phenyl ether phosphoric acid, phosphoric acid tris(2-ethylhexyl) ester, (Z) -Alpha-2-octadekenyl-omega-hydroxypoly(oxy-1,2-ethanyl)phosphate and poly(oxy-1,2-ethaninyl), α-dodecyl-ω-hydroxy-, phosphate , Potassium salt {Poly(oxy-1,2-ethanediyl), α-dodecyl-ω-hydroxy-,phosphate, potassium salt} Cell non-toxic hydrophilic modified coating comprising at least one selected from.
5. The method of claim 1, wherein the alcohol ether-based compound comprises at least one selected from dipropylene glycol monomethyl ether, polyvinyl ether, polyethylene glycol, and alcohol polyoxyethylene ether.
6. The cell-free hydrophilic modified coating agent according to any one of claims 1 to 5, wherein the viscosity measured according to ASTM D7042 standard test (20°C) is 950 to 1,100 mPa·s.
7. Step 1 of preparing a nonwoven fabric;

   A second step of coating part or all of the nonwoven fabric with the cell-free hydrophilic modified coating agent of claim 6;

   Including; 3 step of thermally fixing the hydrophilic modified coating agent to the non-woven fabric by heat treatment to modify the non-woven fabric to be hydrophilic; and,

   The nonwoven fabric of step 1 is a method of manufacturing a non-woven non-woven fabric, characterized in that it contains hydrophobic fibers.
8. As a nonwoven fabric in which part or all of the nonwoven fabric containing hydrophobic fibers is modified with a hydrophilic nonwoven fabric,

   Cell non-toxic non-woven fabric, characterized in that it comprises 0.1 to 3% by weight of the cell non-toxic hydrophilic modified coating agent of claim 6 of the total weight of the non-woven fabric.
9. The non-woven fabric of claim 8, wherein the hydrophobic fibers have an average diameter of 1 μm to 50 μm.
10. The non-woven fabric according to claim 8, wherein the cell viability is 70 to 100% when _{IC 50 is measured according to the ISO 10993-5 method.}