WO2021060947A3 - 유사 세라마이드의 신규한 합성방법 및 그에 관한 중간체 화합물 - Google Patents

유사 세라마이드의 신규한 합성방법 및 그에 관한 중간체 화합물 Download PDF

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Publication number
WO2021060947A3
WO2021060947A3 PCT/KR2020/013161 KR2020013161W WO2021060947A3 WO 2021060947 A3 WO2021060947 A3 WO 2021060947A3 KR 2020013161 W KR2020013161 W KR 2020013161W WO 2021060947 A3 WO2021060947 A3 WO 2021060947A3
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WO
WIPO (PCT)
Prior art keywords
pseudoceramide
intermediates
synthesis method
novel synthesis
improvement
Prior art date
Application number
PCT/KR2020/013161
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English (en)
French (fr)
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WO2021060947A2 (ko
Inventor
박은주
김은택
박진오
이지원
Original Assignee
대봉엘에스 주식회사
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Application filed by 대봉엘에스 주식회사 filed Critical 대봉엘에스 주식회사
Publication of WO2021060947A2 publication Critical patent/WO2021060947A2/ko
Publication of WO2021060947A3 publication Critical patent/WO2021060947A3/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • C07F7/1872—Preparation; Treatments not provided for in C07F7/20
    • C07F7/1892—Preparation; Treatments not provided for in C07F7/20 by reactions not provided for in C07F7/1876 - C07F7/1888

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

본 발명은 피부 보습에 효과가 뛰어나며, 손상된 피부회복 및 예방용 유효물질로 사용 가능한, 피부 외용제, 화장품 조성물 또는 약학 조성물로 사용될 수 있는 PC-104 (Hydroxypropyl Bispalmitamide MEA)와 같은 유사 세라마이드 화합물을 고수율로 용이하게 제조하는 신규 합성 방법 및 그에 관한 중간체 화합물에 관한 것이다. 본 발명은, 유사 세라마이드 제조에 있어서, 부반응의 억제, 수율향상, 순도향상, 공정시간 단축 등의 여러 장점을 가지는 바, 대량생산에 적합하고, 생산비용을 낮출 수 있는 효과가 있다.
PCT/KR2020/013161 2019-09-26 2020-09-25 유사 세라마이드의 신규한 합성방법 및 그에 관한 중간체 화합물 WO2021060947A2 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1020190118644A KR102261829B1 (ko) 2019-09-26 2019-09-26 유사 세라마이드의 신규한 합성방법 및 그에 관한 중간체 화합물
KR10-2019-0118644 2019-09-26

Publications (2)

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WO2021060947A2 WO2021060947A2 (ko) 2021-04-01
WO2021060947A3 true WO2021060947A3 (ko) 2021-05-27

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PCT/KR2020/013161 WO2021060947A2 (ko) 2019-09-26 2020-09-25 유사 세라마이드의 신규한 합성방법 및 그에 관한 중간체 화합물

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KR (1) KR102261829B1 (ko)
WO (1) WO2021060947A2 (ko)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116003281B (zh) * 2022-12-27 2023-10-03 苏州元素集化学工业有限公司 一种利用双羧酸结构合成类神经酰胺化合物的方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20100007169A (ko) * 2008-07-11 2010-01-22 (주)아모레퍼시픽 유사지질 복합체 및 이를 함유하는 피부 외용제 조성물
WO2010010985A1 (en) * 2008-07-24 2010-01-28 Amorepacific Corporation Multi-layered lamellar granule and skin external application composition containing same
WO2019031790A1 (ko) * 2017-08-09 2019-02-14 주식회사 아모레퍼시픽 세라마이드, 이의 유도체 및 목근피 추출물을 함유하는 피부 외용제 조성물

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100539965B1 (ko) 2002-08-29 2006-01-10 주식회사 코리아나화장품 신규한 유사 세라마이드를 포함하는 아토피 피부염 예방및 완화용 화장료 조성물
KR102644587B1 (ko) 2015-12-24 2024-03-07 (주)아모레퍼시픽 유사 세라마이드 화합물 및 그 제조방법

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20100007169A (ko) * 2008-07-11 2010-01-22 (주)아모레퍼시픽 유사지질 복합체 및 이를 함유하는 피부 외용제 조성물
WO2010010985A1 (en) * 2008-07-24 2010-01-28 Amorepacific Corporation Multi-layered lamellar granule and skin external application composition containing same
WO2019031790A1 (ko) * 2017-08-09 2019-02-14 주식회사 아모레퍼시픽 세라마이드, 이의 유도체 및 목근피 추출물을 함유하는 피부 외용제 조성물

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
DUCK-HEE KIM , HO-SIK RHO , JAE WON YOU , JONG CHAN LEE: "Chemoselective N-acylation of amino alcohols promoted by magnesium oxide in aqueous organic solution", TETRAHEDRON LETTERS, vol. 43, no. 3, 7 January 2002 (2002-01-07), pages 277 - 279, XP004312253, ISSN: 0040-4039, DOI: 10.1016/S0040-4039(01)02134-7 *
KIM HAN YOUNG: "Preparation of pseudo-ceramide for cosmetic purpose", JOURNAL OF SKIN BARRIER RESEARCH, vol. 20, no. 1, 1 June 2018 (2018-06-01), KR, pages 9 - 12, XP009528143, ISSN: 1229-4934 *

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Publication number Publication date
WO2021060947A2 (ko) 2021-04-01
KR102261829B1 (ko) 2021-06-07
KR20210036550A (ko) 2021-04-05

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