WO2021054296A1 - Récipient de transport - Google Patents
Récipient de transport Download PDFInfo
- Publication number
- WO2021054296A1 WO2021054296A1 PCT/JP2020/034797 JP2020034797W WO2021054296A1 WO 2021054296 A1 WO2021054296 A1 WO 2021054296A1 JP 2020034797 W JP2020034797 W JP 2020034797W WO 2021054296 A1 WO2021054296 A1 WO 2021054296A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- container
- transport container
- ion
- transport
- ions
- Prior art date
Links
- 150000002500 ions Chemical class 0.000 claims description 157
- 239000000470 constituent Substances 0.000 claims description 25
- 210000004027 cell Anatomy 0.000 claims description 19
- 210000001912 transporting cell Anatomy 0.000 claims description 4
- 230000002776 aggregation Effects 0.000 abstract 1
- 238000004220 aggregation Methods 0.000 abstract 1
- 241000700605 Viruses Species 0.000 description 9
- 241000251468 Actinopterygii Species 0.000 description 6
- 241000894006 Bacteria Species 0.000 description 6
- 230000002411 adverse Effects 0.000 description 6
- 238000002474 experimental method Methods 0.000 description 6
- 239000000463 material Substances 0.000 description 5
- 230000001954 sterilising effect Effects 0.000 description 5
- 238000010586 diagram Methods 0.000 description 4
- 239000007789 gas Substances 0.000 description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- -1 hydrogen ions Chemical class 0.000 description 3
- 235000013372 meat Nutrition 0.000 description 3
- 244000005700 microbiome Species 0.000 description 3
- 239000001301 oxygen Substances 0.000 description 3
- 229910052760 oxygen Inorganic materials 0.000 description 3
- 238000004659 sterilization and disinfection Methods 0.000 description 3
- 230000004083 survival effect Effects 0.000 description 3
- 235000013311 vegetables Nutrition 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 2
- 230000005856 abnormality Effects 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000005401 electroluminescence Methods 0.000 description 2
- 230000006698 induction Effects 0.000 description 2
- 230000007774 longterm Effects 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 210000000056 organ Anatomy 0.000 description 2
- 230000035755 proliferation Effects 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- 241000233866 Fungi Species 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 244000052616 bacterial pathogen Species 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 230000006866 deterioration Effects 0.000 description 1
- 230000002900 effect on cell Effects 0.000 description 1
- 230000005674 electromagnetic induction Effects 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- GPRLSGONYQIRFK-UHFFFAOYSA-N hydron Chemical compound [H+] GPRLSGONYQIRFK-UHFFFAOYSA-N 0.000 description 1
- TUJKJAMUKRIRHC-UHFFFAOYSA-N hydroxyl Chemical compound [OH] TUJKJAMUKRIRHC-UHFFFAOYSA-N 0.000 description 1
- 210000004263 induced pluripotent stem cell Anatomy 0.000 description 1
- 239000011810 insulating material Substances 0.000 description 1
- 239000004973 liquid crystal related substance Substances 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 238000004949 mass spectrometry Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000001590 oxidative effect Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 239000011359 shock absorbing material Substances 0.000 description 1
- 229920002379 silicone rubber Polymers 0.000 description 1
- 239000004945 silicone rubber Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
Images
Classifications
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D81/00—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents
- B65D81/18—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents providing specific environment for contents, e.g. temperature above or below ambient
- B65D81/20—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents providing specific environment for contents, e.g. temperature above or below ambient under vacuum or superatmospheric pressure, or in a special atmosphere, e.g. of inert gas
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D81/00—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents
- B65D81/18—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents providing specific environment for contents, e.g. temperature above or below ambient
- B65D81/20—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents providing specific environment for contents, e.g. temperature above or below ambient under vacuum or superatmospheric pressure, or in a special atmosphere, e.g. of inert gas
- B65D81/2069—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents providing specific environment for contents, e.g. temperature above or below ambient under vacuum or superatmospheric pressure, or in a special atmosphere, e.g. of inert gas in a special atmosphere
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/02—Preservation of living parts
- A01N1/0236—Mechanical aspects
- A01N1/0263—Non-refrigerated containers specially adapted for transporting or storing living parts whilst preserving, e.g. cool boxes, blood bags or "straws" for cryopreservation
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K63/00—Receptacles for live fish, e.g. aquaria; Terraria
- A01K63/02—Receptacles specially adapted for transporting live fish
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/02—Preservation of living parts
- A01N1/0236—Mechanical aspects
- A01N1/0263—Non-refrigerated containers specially adapted for transporting or storing living parts whilst preserving, e.g. cool boxes, blood bags or "straws" for cryopreservation
- A01N1/0273—Transport containers
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/02—Preservation of living parts
- A01N1/0278—Physical preservation processes
- A01N1/0294—Electromagnetic, i.e. using electromagnetic radiation or electromagnetic fields
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23B—PRESERVING, e.g. BY CANNING, MEAT, FISH, EGGS, FRUIT, VEGETABLES, EDIBLE SEEDS; CHEMICAL RIPENING OF FRUIT OR VEGETABLES; THE PRESERVED, RIPENED, OR CANNED PRODUCTS
- A23B4/00—General methods for preserving meat, sausages, fish or fish products
- A23B4/015—Preserving by irradiation or electric treatment without heating effect
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23B—PRESERVING, e.g. BY CANNING, MEAT, FISH, EGGS, FRUIT, VEGETABLES, EDIBLE SEEDS; CHEMICAL RIPENING OF FRUIT OR VEGETABLES; THE PRESERVED, RIPENED, OR CANNED PRODUCTS
- A23B7/00—Preservation or chemical ripening of fruit or vegetables
- A23B7/015—Preserving by irradiation or electric treatment without heating effect
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D77/00—Packages formed by enclosing articles or materials in preformed containers, e.g. boxes, cartons, sacks or bags
- B65D77/04—Articles or materials enclosed in two or more containers disposed one within another
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D85/00—Containers, packaging elements or packages, specially adapted for particular articles or materials
- B65D85/50—Containers, packaging elements or packages, specially adapted for particular articles or materials for living organisms, articles or materials sensitive to changes of environment or atmospheric conditions, e.g. land animals, birds, fish, water plants, non-aquatic plants, flower bulbs, cut flowers or foliage
Definitions
- One aspect of the present invention relates to a container for transporting biological constituents.
- the present application claims priority based on Japanese Patent Application No. 2019-169616 filed in Japan on September 18, 2019, the contents of which are incorporated herein by reference.
- Patent Document 1 discloses a fresh fish transport container including an inner case made of foamed resin and having an internal space for accommodating fresh fish, and an outer case made of corrugated cardboard and accommodating an inner case.
- Patent Document 1 has a problem that it is difficult to transport it for a long time because various germs and the like proliferate with the passage of time.
- One aspect of the present invention has been made in view of the above problems, and an object of the present invention is to provide a transport container capable of long-term transport.
- the transport container is a transport container for transporting cells or biological constituents which are aggregates of cells, and is inside the transport container by electric discharge. It is characterized by comprising a discharge device for generating a discharge product.
- FIG. 1 is a diagram showing a configuration of a transport container 1 according to the first embodiment.
- the transport container 1 is a container for transporting cells or biological constituents which are aggregates of cells.
- the biological construct is a mammalian-derived cell, tissue, or organ.
- the transport container 1 includes a primary container 10, a secondary container 20, a tertiary container 30, and an ion generator (discharge device) 40.
- the transport container 1 can contain the biological constituents in a state of being shielded from the external environment, as compared with, for example, a container having no primary container 10 and a secondary container 20.
- the primary container 10 is a rectangular parallelepiped container that directly houses biological constituents.
- the primary container 10 is not limited to a rectangular parallelepiped container as long as it has a structure capable of accommodating biological constituents.
- At least a part of the primary container 10 is made of a material that allows gas to pass through. Examples of such materials include silicone rubber and the like.
- the upper surface of the primary container 10 is made of a material that allows gas to pass through.
- the upper surface portion is a portion that faces vertically upward in a state where the biological constituent is transported by the transport container 1.
- the secondary container 20 is a rectangular parallelepiped container that houses the primary container 10.
- the secondary container 20 is not limited to a rectangular parallelepiped container as long as it has a configuration capable of accommodating the primary container 10.
- the secondary container 20 does not have airtightness. That is, gas such as air can enter and exit the secondary container 20.
- the secondary container 20 is configured so that the inner surface does not come into contact with the primary container 10. As a result, when an impact is applied to the secondary container 20 from the outside, the degree to which the impact is transmitted to the primary container 10 can be reduced.
- the tertiary container 30 is a closed rectangular parallelepiped container that houses the secondary container 20.
- the tertiary container 30 is not limited to a rectangular parallelepiped container as long as it has a configuration capable of accommodating the secondary container 20.
- the tertiary container 30 includes a storage portion 31 and a lid portion 35.
- the storage unit 31 is a bottomed tubular container that stores the secondary container 20.
- the accommodating portion 31 has a secondary container 20 and an opening 32 for receiving biological constituents on the upper side when the bottom portion is on the lower side.
- the lid 35 closes the opening 32.
- the lid portion 35 is a plate-shaped member having a shape capable of covering the opening portion 32.
- the lid portion 35 has recesses 37A and 37B on the inner surface 38.
- the tertiary container 30 is in a sealed state.
- an O-ring (not shown) is provided in the opening 32, and the lid 35 covers the opening 32 via the O-ring.
- the lid portion 35 is connected to the accommodating portion 31 via a hinge 34 provided along the longitudinal direction of the accommodating portion 31. By rotating the lid 35 around the hinge 34, it is possible to switch between a state in which the lid 35 covers the opening 32 and a state in which the lid 35 is opened.
- the tertiary container 30 is configured to form a space between the tertiary container 30 and the secondary container 20 so that the inner surface does not come into contact with the secondary container 20.
- a shock absorbing material (not shown) and / or a heat insulating material (not shown) for reducing the temperature change of the secondary container 20 are arranged between the secondary container 20 and the tertiary container 30.
- the tertiary container 30 may have a handle portion on the outer surface for transporting the transport container 1 by the user.
- the handle portion include a grip portion for gripping by hand, a shoulder hook portion for hanging on the shoulder, and the like.
- the ion generator 40 is a discharge device that generates positive ions and negative ions (discharge products) inside the transport container 1 by electric discharge.
- the ion generator 40 may be a discharge device that generates only either positive ions or negative ions inside the transport container 1 by electric discharge.
- the ion generator 40 generates positive ions and negative ions in the space between the tertiary container 30 and the secondary container 20.
- the transport container 1 includes two ion generators 40.
- the number of ion generators 40 may be one or three or more as long as it is determined by the designer according to the target ion concentration and the size of the tertiary container 30.
- the transport container 1 may include a device for generating a discharge product different from the ions instead of the ion generator 40.
- a discharge device that produces a discharge product capable of antibacterial, sterilizing, or sterilizing viruses and bacteria in the transport container 1 by electric discharge instead of the ion generator 40.
- Examples of the discharge method include plasma discharge and corona discharge.
- the ion generator 40 is provided inside the lid 35. Therefore, the ions generated by the ion generator 40 are efficiently diffused inside the transport container 1.
- the ion generator 40 does not necessarily have to be provided inside the lid portion 35, and may be provided, for example, inside the accommodating portion 31.
- the ion generator 40 is provided in the recesses 37A and 37B provided on the inner surface 38 of the lid portion 35, respectively. More specifically, the ion generator 40 is provided so as not to protrude inward from the inner surface 38 of the lid portion 35. Therefore, the possibility that the ion generator 40 collides with the secondary container 20 or the like and fails is reduced. However, the ion generator 40 does not necessarily have to be provided in the recesses 37A and 37B, and may be provided directly in the inner surface 38.
- a battery 36 as a power source and a feeder line 39 for electrically connecting the battery 36 and the ion generator 40 are embedded inside the lid portion 35.
- the battery 36 may be provided inside the lid portion 35.
- the ion generator 40 is supplied with power from the battery 36 via the power supply line 39.
- the ion generator 40 may be supplied with power from the outside via the lid portion 35.
- a feeder line connecting the inside and the outside of the lid 35 may be provided.
- the battery 36 arranged outside the tertiary container 30 is connected to the ion generator 40 via the feeding line and functions as an external power source for supplying electric power.
- the battery 36 arranged outside the tertiary container 30 may supply power to the ion generator 40 by electromagnetic induction. In this case, by replacing the battery 36 as needed, the generation of the discharge product can be continued with the lid 35 closed.
- the transport container 1 since the battery 36 can be replaced without opening the lid 35, it is possible to prevent viruses, bacteria, and the like from invading the inside of the transport container 1 when the battery 36 is replaced.
- FIG. 2 is a diagram showing the configuration of the ion generator 40. As shown in FIG. 2, the ion generator 40 has a rectangular shape in a plan view. The ion generator 40 includes two ion generators 48A and 48B arranged along the longitudinal direction.
- the battery 36 supplies electric power to the ion generating units 48A and 48B. Ions are generated by corona discharge of each of the ion generating section 48A and the ion generating section 48B.
- the ion generation unit 48A generates positive ions, and the ion generation unit 48B generates negative ions. However, the ion generation unit 48A may generate negative ions, and the ion generation unit 48B may generate positive ions.
- the ion generating portions 48A and 48B each have sharpened discharge electrode protrusions 48Aa and 48Ba, and induction electrode rings 48Ab and 48Bb surrounding the discharge electrode protrusions 48Aa and 48Ba, respectively.
- the discharge electrode protrusions 48Aa and 48Ba are arranged at the centers of the induction electrode rings 48Ab and 48Bb, respectively.
- the convex discharge electrode 48Aa, 48Ba may be a surface electrode, a needle electrode, a brush electrode, or the like, and the shape, type, and material of the convex discharge electrode 48Aa, 48Ba may be used as long as the discharge electrode can be discharged.
- a positive voltage is applied to the ion generating unit 48A.
- a positive voltage is applied to the ion generating portion 48A, water molecules in the air are electrically decomposed by electric discharge, and mainly hydrogen ions H + are generated. Then, water molecules in the air aggregate around the generated hydrogen ion H + , and a stable cluster ion H + (H 2 O) m having a positive charge is formed.
- a negative voltage is applied to the ion generating unit 48B.
- oxygen molecules in the air are electrically decomposed by electric discharge, and oxygen ions O 2 ⁇ are mainly generated.
- the resulting oxygen ions O 2 - water molecules in the air are agglomerated around the charge negative stable cluster ions O 2 - (H 2 O) n are formed.
- n are arbitrary integers.
- positive ion means a positive cluster ion
- negative ion means a negative cluster ion.
- the formation of positive and negative cluster ions can be confirmed by flight time decomposition type mass spectrometry.
- the ion generating device 40 the concentration of positive ions and negative ions in the transport container 1 supplies positive ions and negative ions so that each becomes 7,000 / cm 3 or more. If positive and negative ion concentrations 7,000 / cm 3 or more, respectively, can reduce the growth and proliferation of such bacteria and viruses.
- the tertiary container 30 and the secondary container 20 are connected by generating positive and negative ions by the ion generator 40 and supplying the positive and negative ions to the inside of the tertiary container 30.
- the virus existing in the space between them can be inactivated and preferably eradicated.
- the secondary container 20 is not sealed.
- the upper surface of the primary container 10 is made of a material that allows gas to pass through. Therefore, in the transport container 1, even the insides of the primary container 10 and the secondary container 20 can be sterilized by the ions generated by the ion generator 40.
- the inside was sterilized with a chemical (for example, alcohol such as ethanol) before containing the biological constituents.
- a chemical for example, alcohol such as ethanol
- the biological constituent is contained before the drug is completely vaporized, there is a problem that the residual drug vaporized inside adversely affects the biological constituent (particularly cells).
- viruses, bacteria and the like invade again when the biological constituents are accommodated.
- the UV lamp is installed in the conventional transport container, there is a problem that the biological constituents (particularly cells) are adversely affected.
- ions can be generated by the ion generator 40 as needed to continuously sterilize the inside.
- the ion generator 40 may further include a fan. As a result, positive ions and negative ions diffuse inside the transport container 1, so that sterilization can be performed more efficiently.
- Examples of biological constituents transported by the transport container 1 include iPS cells (induced pluripotent stem cells).
- the inventor of the present application conducted an experiment to confirm the effect of ions on iPS cells.
- iPS cells were cultured for 7 days in an incubator with and without a PCI (plasmacluster ion) generator, and the number of cells on the final day was counted.
- the concentration of ions PCI generating device generates were as 212,000 pieces / cm 3 on average.
- FIG. 3 is a table showing the results of the experiment.
- FIG. 3 shows three results for each with and without a PCI generator.
- the average survival rate ⁇ standard deviation of iPS cells in the incubator equipped with the PCI generator was 91.5 ⁇ 1.31%.
- the average survival rate ⁇ standard deviation of iPS cells in the incubator without the PCI generator was 92.5 ⁇ 1.57%. That is, there was no significant difference in the average survival rate and standard deviation of iPS cells after the experiment depending on whether or not the PCI generator was installed. Therefore, it can be said that even if the transport container 1 is provided with the ion generator 40, it does not adversely affect the cells. Therefore, according to the transport container 1, sterilization can be performed without adversely affecting iPS cells.
- the inside can be sterilized without affecting the biological constituents. Therefore, it is possible to suppress the deterioration of the biological constituents due to the fungus and transport them for a long time.
- FIG. 4 is a diagram showing the configuration of the transport container 2 according to the second embodiment. As shown in FIG. 4, the transport container 2 includes an ion sensor 50 and a display unit 51 in addition to the configuration of the transport container 1.
- the ion sensor 50 is a sensor that detects the ion concentration in the transport container 2 and outputs a signal corresponding to the ion concentration.
- the ion sensor 50 detects the concentration of one or both of positive ions and negative ions in the transport container 2.
- the ion sensors 50 are provided in two places inside the lid portion 35.
- the number of ion sensors 50 may be determined by the designer according to the target ion concentration detection accuracy and the size of the tertiary container 30, and may be one or three or more. Further, the ion sensor 50 may be provided inside the accommodating portion 31.
- the display unit 51 is a display device that displays the ion concentration detected by the ion sensor 50 or information based on the ion concentration.
- the display unit 51 is, for example, a liquid crystal display or an organic EL (Electro Luminescence) display.
- the information based on the ion concentration includes information on whether or not the operation of the ion generator 40 is normal, or information on the replacement time of the ion generator 40.
- the transport container 2 may include a control unit that executes a process of determining the state of the ion generator 40 based on the ion concentration.
- the display unit 51 has a rectangular shape and is provided on the outer surface of the accommodating unit 31.
- the display unit 51 is not limited to the above example as long as it can display the ion concentration detected by the ion sensor 50 or information based on the ion concentration.
- the display unit 51 may have a circular shape.
- the display unit 51 may be provided on the outer surface of the lid unit 35.
- the user can recognize the state of the ion generator 40 based on the display of the display unit 51. Therefore, when an abnormality occurs in the operation of the ion generator 40, it is possible to take measures such as performing maintenance on the ion generator 40. Therefore, according to the transport container 2, it is possible to more reliably generate ions and sterilize the inside.
- FIG. 5 is a diagram showing the configuration of the transport container 3 according to the third embodiment.
- the transport container 3 has a configuration in which the lid portion 35 and the accommodating portion 31 are not connected via a hinge 34. Since the transport container 3 does not have the hinge 34, the number of parts can be reduced. Therefore, the transport container 3 can reduce the manufacturing cost as compared with the transport containers 1 and 2.
- the biological constituents contained in the transport containers 1, 2 and 3 are not limited to the above-mentioned mammalian-derived cells, tissues, or organs, and may be meat, fresh fish, vegetables, or the like. According to the transport containers 1, 2 and 3, meat, fresh fish, vegetables and the like can also be transported for a long time while maintaining their freshness.
- the transport containers 1, 2 and 3 do not need to be provided with the primary container 10 and the secondary container 20 because the need to handle the biological constituents excessively carefully is small. That is, when transporting meat, fresh fish, vegetables, or the like, the transport containers 1, 2, and 3 may be provided with a tertiary container 30 and an ion generator 40. Since the number of parts of such transport containers 1, 2, and 3 can be reduced as compared with those provided with the primary container 10 and the secondary container 20, the manufacturing cost can be reduced.
- the transport container according to the first aspect of the present invention is a transport container for transporting cells or biological constituents which are aggregates of cells, and is a discharge device that generates a discharge product inside the transport container by electric discharge. Be prepared.
- the virus existing inside the transport container can be inactivated and sterilized suitably. Therefore, it is possible to provide a transport container capable of transporting for a long time.
- the transport container according to the second aspect of the present invention includes a storage portion having an opening for receiving the biological component and a lid portion for closing the opening, and the discharge device includes the lid. It may be provided inside the portion.
- the ions generated by the discharge device efficiently diffuse inside the transport container.
- the lid portion may have a recess on the inner surface, and the discharge device may be provided in the recess.
- the possibility that the discharge device collides with a transport container or the like and fails is reduced as compared with the configuration in which the discharge device is not provided in the recess.
- the discharge device may be supplied with power from an external power source via the lid portion.
- the transport container according to the fifth aspect of the present invention may be an ion generator that generates positive ions and negative ions in any one of the above aspects 1 to 4.
- positive ions and negative ions are generated by an ion generator and supplied to the inside of the transport container, whereby the virus existing inside the transport container can be inactivated and sterilized suitably. it can.
- Transport container in the above 5, wherein the discharge device, the concentration of positive ions and negative ions in the transport vessel, positive ions and negative so that each becomes 7,000 / cm 3 or more Ions may be supplied.
- Transport container in the above 6, wherein the discharge device, the concentration of positive ions and negative ions in the transport vessel, respectively 7,000 / cm 3 or more, 1,000,000 / cm 3 or less Positive ions and negative ions may be supplied so as to be.
- the bacteria can be sterilized without adversely affecting the cells.
- the transport container according to the eighth aspect of the present invention has an ion sensor that detects the concentration of one or both of positive ions and negative ions in the transport container and the ion sensor that detects the concentration in any one of the above aspects 5 to 7. It may be provided with an ion concentration or a display unit for displaying information based on the ion concentration.
- the user can know the ion concentration in the shipping container.
- the user can recognize information based on the ion concentration in the shipping container. For example, when an abnormality occurs in a shipping container, the user can recognize the abnormal occurrence state.
- the transport container according to the ninth aspect of the present invention is the primary container containing the biological constituents, the secondary container containing the primary container, and the tertiary container containing the secondary container in the above aspects 1 to 8.
- the discharge device may generate the discharge product in the space between the tertiary container and the secondary container.
- positive ions and negative ions are generated by a discharge device, and positive ions and negative ions are supplied to the inside of the tertiary container, thereby between the tertiary container and the secondary container.
- the virus existing in the space can be inactivated and can be preferably eradicated.
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Abstract
L'invention concerne un récipient de transport pour le transport de composants biologiques qui sont des cellules ou une agrégation de cellules, ledit récipient étant pourvu d'un dispositif de génération d'ions pour générer un produit de décharge à l'intérieur du récipient de transport au moyen d'une décharge électrique.
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
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US17/623,826 US11999552B2 (en) | 2019-09-18 | 2020-09-15 | Transport container |
CN202080048640.3A CN114364617B (zh) | 2019-09-18 | 2020-09-15 | 输送容器 |
JP2021546659A JPWO2021054296A1 (fr) | 2019-09-18 | 2020-09-15 |
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JP2019169616 | 2019-09-18 | ||
JP2019-169616 | 2019-09-18 |
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WO2021054296A1 true WO2021054296A1 (fr) | 2021-03-25 |
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Application Number | Title | Priority Date | Filing Date |
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PCT/JP2020/034797 WO2021054296A1 (fr) | 2019-09-18 | 2020-09-15 | Récipient de transport |
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US (1) | US11999552B2 (fr) |
JP (1) | JPWO2021054296A1 (fr) |
CN (1) | CN114364617B (fr) |
WO (1) | WO2021054296A1 (fr) |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2012134000A (ja) * | 2010-12-21 | 2012-07-12 | Sharp Corp | イオン発生機及びイオン発生機の掃除方法 |
JP2014215020A (ja) * | 2013-04-30 | 2014-11-17 | シャープ株式会社 | 冷蔵庫 |
JP2015043753A (ja) * | 2013-08-29 | 2015-03-12 | シャープ株式会社 | イオン照射装置およびそれを冷蔵による保管を必要とする食品に適用した方法 |
Family Cites Families (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8820532B2 (en) * | 2012-04-06 | 2014-09-02 | Quick Cable Corporation | Leak-proof packaging for wet batteries |
WO2013186815A1 (fr) * | 2012-06-14 | 2013-12-19 | Empire Technology Development Llc | Dispositifs et procédés de conservation de produit alimentaire |
US9539722B2 (en) * | 2012-12-19 | 2017-01-10 | Milwaukee Electric Tool Corporation | Tool storage devices |
US20140262884A1 (en) * | 2013-03-14 | 2014-09-18 | Apothecary Products, Inc. | Medicine storage arrangements and methods of assembly and use |
CN204473527U (zh) * | 2015-02-13 | 2015-07-15 | 青岛市市立医院 | 一种检验科用标本运输恒温箱 |
CN204568226U (zh) * | 2015-05-04 | 2015-08-19 | 湖南城市学院 | 一种多功能企业物品存放盒 |
CN107178946A (zh) * | 2016-03-11 | 2017-09-19 | 广东工业大学 | 一种多功能冷藏运输箱 |
CN106144240B (zh) * | 2016-09-18 | 2018-08-07 | 成都测迪森生物科技有限公司 | 一种便携组织样本箱 |
CN106395154A (zh) * | 2016-11-24 | 2017-02-15 | 杭州莱普晟医疗科技有限公司 | 数字化互联网离体器官转运装置系统及其应用方法 |
CN207804655U (zh) * | 2017-05-22 | 2018-09-04 | 赵晋娴 | 一种用于生活用品的便携式消毒装置 |
CN107098042A (zh) * | 2017-06-28 | 2017-08-29 | 江苏展邦智能科技有限公司 | 一种智能安防文物运输箱 |
JP6966068B2 (ja) | 2017-10-02 | 2021-11-10 | トーホー工業株式会社 | 鮮魚輸送容器 |
CN108584189A (zh) * | 2017-12-25 | 2018-09-28 | 香港以沫科技有限公司 | 一种高性能环境恒定货运集装箱 |
JP2021042861A (ja) * | 2017-12-28 | 2021-03-18 | シャープ株式会社 | 冷蔵庫 |
CN207712530U (zh) * | 2018-01-10 | 2018-08-10 | 三峡大学 | 一种免疫接种盒 |
CN208119858U (zh) * | 2018-04-08 | 2018-11-20 | 中科政兴(上海)医疗科技有限公司 | 一种细胞长距离储存转运箱 |
CN208393986U (zh) * | 2018-04-19 | 2019-01-18 | 孙纲 | 一种乙型肝炎病毒检测试剂盒 |
CN208499283U (zh) * | 2018-07-12 | 2019-02-15 | 湖南未名三胞转化医学科技有限公司 | 一种便携式干细胞低温运输箱 |
CN208665854U (zh) * | 2018-07-12 | 2019-03-29 | 深圳市一五零生命科技有限公司 | 用于干细胞的运输箱 |
-
2020
- 2020-09-15 US US17/623,826 patent/US11999552B2/en active Active
- 2020-09-15 CN CN202080048640.3A patent/CN114364617B/zh active Active
- 2020-09-15 JP JP2021546659A patent/JPWO2021054296A1/ja active Pending
- 2020-09-15 WO PCT/JP2020/034797 patent/WO2021054296A1/fr active Application Filing
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2012134000A (ja) * | 2010-12-21 | 2012-07-12 | Sharp Corp | イオン発生機及びイオン発生機の掃除方法 |
JP2014215020A (ja) * | 2013-04-30 | 2014-11-17 | シャープ株式会社 | 冷蔵庫 |
JP2015043753A (ja) * | 2013-08-29 | 2015-03-12 | シャープ株式会社 | イオン照射装置およびそれを冷蔵による保管を必要とする食品に適用した方法 |
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CN114364617B (zh) | 2023-10-17 |
CN114364617A (zh) | 2022-04-15 |
US11999552B2 (en) | 2024-06-04 |
JPWO2021054296A1 (fr) | 2021-03-25 |
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