WO2021042239A1 - 一种超声刺激方法及装置 - Google Patents

一种超声刺激方法及装置 Download PDF

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Publication number
WO2021042239A1
WO2021042239A1 PCT/CN2019/104015 CN2019104015W WO2021042239A1 WO 2021042239 A1 WO2021042239 A1 WO 2021042239A1 CN 2019104015 W CN2019104015 W CN 2019104015W WO 2021042239 A1 WO2021042239 A1 WO 2021042239A1
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WIPO (PCT)
Prior art keywords
stimulation
target
ultrasonic
point
ultrasonic transducer
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PCT/CN2019/104015
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English (en)
French (fr)
Inventor
郑海荣
黄小伟
牛丽丽
孟龙
林争荣
周伟
边天元
方佳朕
Original Assignee
深圳先进技术研究院
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Application filed by 深圳先进技术研究院 filed Critical 深圳先进技术研究院
Priority to PCT/CN2019/104015 priority Critical patent/WO2021042239A1/zh
Publication of WO2021042239A1 publication Critical patent/WO2021042239A1/zh

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy

Definitions

  • This application belongs to the field of medical technology, and in particular relates to an ultrasonic stimulation method and device.
  • Physical neuromodulation technology is an important method used in neuroscience research and neurological disease intervention. Combining the basic principles of electricity, magnetism, light and neuroscience to produce nerve stimulation and regulation technologies such as deep brain electrical stimulation, transcranial magnetic stimulation, and optical gene regulation.
  • medical ultrasound as a non-invasive diagnosis and treatment technology, can form a focus in the human body, target a specific area of tissue, and have the function of regulating peripheral nerves.
  • the current medical ultrasound device is usually applied to brain nerve stimulation, and when it is applied to the human trunk for nerve stimulation, there are problems that it is not easy to find the target point and the stimulation location is not accurate.
  • the embodiments of the present application provide an ultrasonic stimulation method and device to solve the problems of difficulty in finding a target point and inaccurate stimulation positioning when a medical ultrasonic device is applied to a human trunk to perform nerve stimulation in the prior art.
  • the first aspect of the embodiments of the present application provides an ultrasonic stimulation method, including:
  • an ultrasonic stimulation operation is performed.
  • the second aspect of the embodiments of the present application provides an ultrasonic stimulation device, including:
  • the acquisition module is used to acquire the ultrasound stimulation target area of the organ
  • a position adjustment module for adjusting the fixed position of the ultrasonic transducer based on each stimulation detection point determined in the ultrasonic stimulation target area
  • a target point determination module configured to determine a target stimulation target point from the stimulation detection points based on the stimulation feedback results of the ultrasound stimulation at the different fixed positions
  • the ultrasonic stimulation module is used to perform an ultrasonic stimulation operation based on the target stimulation target point.
  • the third aspect of the embodiments of the present application provides a terminal, including a memory, a processor, and a computer program stored in the memory and running on the processor.
  • the processor executes the computer program when the computer program is executed. The steps of the method as described in the first aspect.
  • a fourth aspect of the embodiments of the present application provides a computer-readable storage medium that stores a computer program that, when executed by a processor, implements the steps of the method described in the first aspect.
  • the fifth aspect of the present application provides a computer program product.
  • the computer program product includes a computer program that, when executed by one or more processors, implements the steps of the method described in the above first aspect.
  • the ultrasonic stimulation target area of the organ is acquired, the fixed position of the ultrasonic transducer is adjusted based on each stimulation detection point determined in the ultrasonic stimulation target area, and the stimulation feedback results of the ultrasonic stimulation at different fixed positions are adjusted.
  • Determine the target stimulus target point from the stimulus detection points perform the ultrasonic stimulation operation, and realize the target stimulus target that meets the requirements from the stimulation detection points set in the ultrasonic stimulation target area by adjusting the fixing device of the ultrasonic transducer Point, in order to improve the convenience of finding the target point and the accuracy of the ultrasonic stimulation operation when the ultrasound device is applied to the human trunk to perform nerve stimulation.
  • Fig. 1 is a first flow chart of an ultrasonic stimulation method provided by an embodiment of the present application
  • Fig. 2 is a second flowchart of an ultrasonic stimulation method provided by an embodiment of the present application
  • FIG. 3 is a schematic diagram of setting geometric position points in a three-dimensional detection area provided by an embodiment of the present application.
  • FIG. 4 is a structural diagram of a fixing device for an ultrasonic transducer provided by an embodiment of the present application
  • Fig. 5 is a structural diagram of an ultrasonic stimulation device provided by an embodiment of the present application.
  • Fig. 6 is a structural diagram of a terminal provided by an embodiment of the present application.
  • the term “if” can be interpreted as “when” or “once” or “in response to determination” or “in response to detection” depending on the context .
  • the phrase “if determined” or “if detected [described condition or event]” can be interpreted as meaning “once determined” or “in response to determination” or “once detected [described condition or event]” depending on the context ]” or “in response to detection of [condition or event described]”.
  • the terminals described in the embodiments of the present application include but are not limited to other portable devices such as mobile phones with touch-sensitive surfaces (for example, touch screen displays and/or touch pads), laptop computers, or tablet computers. It should also be understood that in some embodiments, the device is not a portable communication device, but a desktop computer with a touch-sensitive surface (e.g., touch screen display and/or touch pad).
  • a terminal including a display and a touch-sensitive surface is described.
  • the terminal may include one or more other physical user interface devices such as a physical keyboard, mouse, and/or joystick.
  • the terminal supports various applications, such as one or more of the following: drawing application, presentation application, word processing application, website creation application, disk burning application, spreadsheet application, game application, telephone application Applications, video conferencing applications, email applications, instant messaging applications, exercise support applications, photo management applications, digital camera applications, digital camera applications, web browsing applications, digital music player applications, and / Or digital video player application.
  • applications such as one or more of the following: drawing application, presentation application, word processing application, website creation application, disk burning application, spreadsheet application, game application, telephone application Applications, video conferencing applications, email applications, instant messaging applications, exercise support applications, photo management applications, digital camera applications, digital camera applications, web browsing applications, digital music player applications, and / Or digital video player application.
  • Various application programs that can be executed on the terminal can use at least one common physical user interface device such as a touch-sensitive surface.
  • a touch-sensitive surface One or more functions of the touch-sensitive surface and corresponding information displayed on the terminal can be adjusted and/or changed between applications and/or within corresponding applications.
  • the common physical architecture of the terminal for example, a touch-sensitive surface
  • an ultrasonic stimulation method includes the following steps:
  • Step 101 Obtain the ultrasound stimulation target area of the organ.
  • the ultrasound stimulation method is a means of peripheral nerve stimulation, which can be applied to peripheral nerve stimulation of different organs, including: heart, spleen, liver, pancreas, gallbladder, etc., to interfere with related diseases by stimulating targets of different organs.
  • the ultrasound stimulation target area of the acquired organ includes:
  • a three-dimensional guide map is established according to the medical image of the organ; and the ultrasonic stimulation target area of the organ is obtained based on the selection operation of the region in the three-dimensional guide map.
  • the medical image may be, for example, an ultrasound image, a magnetic resonance image, an electronic computed tomography image, etc.
  • the device creates a three-dimensional guide map based on the medical image, and the operator (doctor) uses the information (image form, or related information) in the three-dimensional guide map. Functional information, etc.) Determine the stimulation area and implement the area selection operation.
  • the selection operation includes but is not limited to: click operation, drag operation in the three-dimensional guide map, touch gesture combination operation on the display screen, etc.
  • Step 102 Adjust the fixed position of the ultrasound transducer based on each stimulation detection point determined in the ultrasound stimulation target area.
  • Ultrasonic transducers can convert the input electric power into ultrasonic waves for transmission, and convert the received ultrasonic waves into electric signals.
  • the stimulation detection point in the target area may be determined on the basis of the ultrasonic stimulation target area, and the stimulation detection point is at least one.
  • the stimulus detection point is used for ultrasonic stimulus detection based on the adjustment of the fixed position of the ultrasonic transducer.
  • medical images can observe the morphology of organs, it can guide the three-dimensional fixation device of the ultrasound transducer to move the ultrasound transducer to the stimulated target area (larger range). For some targets, there are less The intervention situation requires further search for the optimal stimulus target.
  • the method further includes:
  • the ultrasonic transducer In the process of adjusting the fixed position of the ultrasonic transducer based on each stimulus detection point determined in the ultrasonic stimulation target area, every time the fixed position of the ultrasonic transducer is adjusted, the ultrasonic transducer will be controlled once.
  • the device emits ultrasonic waves for the operation process of ultrasonic stimulation, and realizes the transmission of ultrasonic waves at different fixed positions for ultrasonic stimulation detection.
  • every time the ultrasound is emitted at a fixed position the corresponding ultrasound echo and the corresponding patient physiological data will be collected, so as to realize the acquisition of the feedback information of the stimulation result of the ultrasound stimulation at the current fixed position.
  • the ultrasound echo can be used to realize the imaging display of the stimulation site after stimulation, for the doctor or operator to perform observation, and to judge the stimulation result in combination with the corresponding collected patient physiological data.
  • the ultrasonic stimulation parameters can be set through the electronic control system, including: ultrasonic frequency, pulse duration, fundamental frequency, number of fundamental waves, pulse length, number of pulses The number, pulse repetition frequency, intensity, etc., the ultrasound stimulation parameters can be based on the patient’s condition information (such as the patient’s disease type, severity, etc.), the pathological parameters of the organ where the stimulation detection point is (such as organ size, depth Etc.) to achieve certainty.
  • the ultrasonic stimulation parameters can be implemented at different stimulation detection points.
  • Step 103 Determine a target stimulation target point from the stimulation detection points based on the stimulation feedback results of the ultrasound stimulation at the different fixed positions.
  • This process compares the stimulus feedback results of ultrasound stimulation at different fixed positions, finds the stimulus feedback result with the best stimulus feedback result, and then obtains the best fixed position corresponding to the best stimulus feedback result, which is consistent with the best fixed position.
  • the stimulus detection point corresponding to the position is determined as the target stimulus target point.
  • the stimulus feedback results can be obtained through the monitoring of electrophysiological information, such as detecting the patient’s brain electricity, electrocardiogram, myoelectricity, heart rate, body temperature, blood oxygen, blood oxygen saturation and other physiological information after ultrasound stimulation. It can be combined with some information to achieve the acquisition of stimulus feedback results.
  • electrophysiological information such as detecting the patient’s brain electricity, electrocardiogram, myoelectricity, heart rate, body temperature, blood oxygen, blood oxygen saturation and other physiological information after ultrasound stimulation. It can be combined with some information to achieve the acquisition of stimulus feedback results.
  • Step 104 Perform an ultrasonic stimulation operation based on the target stimulation target point.
  • the target stimulation target can be used as the target for ultrasound stimulation.
  • the operation stimulation operation is specifically controlling the ultrasonic transducer to emit ultrasonic waves toward the target stimulation target point.
  • the target stimulus target point corresponds to the optimal stimulus feedback effect. Or it corresponds to the stimulus feedback effect set by the operator that meets the set requirements.
  • the performing an ultrasonic stimulation operation based on the target stimulating target point includes:
  • the ultrasonic stimulation method in the embodiment of the present application obtains the ultrasonic stimulation target area of the organ, adjusts the fixed position of the ultrasonic transducer based on each stimulation detection point determined in the ultrasonic stimulation target area, and adjusts the fixed position of the ultrasonic transducer based on the ultrasonic stimulation at different fixed positions
  • the stimulus feedback results determine the target stimulus target point from the stimulus detection points, perform the ultrasonic stimulation operation, and realize the detection of the stimulation detection points set in the ultrasonic stimulation target area through the modulation of the fixing device of the ultrasonic transducer.
  • the target stimulation target point is used to improve the convenience of finding the target point and the accuracy of the ultrasonic stimulation operation when the ultrasonic device is applied to the human trunk to perform nerve stimulation.
  • the embodiments of the present application also provide different implementations of the ultrasonic stimulation method.
  • an ultrasonic stimulation method includes the following steps:
  • Step 201 Obtain the ultrasound stimulation target area of the organ.
  • the ultrasound stimulation method is a means of peripheral nerve stimulation, which can be applied to peripheral nerve stimulation of different organs, including: heart, spleen, liver, pancreas, gallbladder, etc., to interfere with related diseases by stimulating targets of different organs.
  • Step 202 using the current coordinates in the ultrasound stimulation target area as a reference point to establish a three-dimensional detection area with a specific shape.
  • a certain coordinate in the ultrasonic stimulation target area is used as a reference point to establish a three-dimensional detection area corresponding to the one coordinate, and an ergodic ultrasonic stimulation detection process of the probe point is performed in the three-dimensional detection area.
  • the specific shape may be a cube shape, a rectangular parallelepiped shape, a spherical shape, and the like.
  • Step 203 Based on the three-dimensional detection area, control the fixing device of the ultrasonic transducer to sequentially move the ultrasonic transducer to a set geometric position point in the three-dimensional detection area.
  • the set geometric position point includes at least one of a vertex, a midpoint of a side, a midpoint of a plane, and a golden ratio dividing point of the side in the three-dimensional detection area of a specific shape.
  • the fixing device of the ultrasonic transducer includes: a first fixing rod X with a function of telescoping in a first direction, a second fixing rod Y with a function of telescoping in a second direction, and The third fixed rod Z with a three-direction telescopic function, wherein the first direction, the second direction, and the third direction are perpendicular to each other, and the first fixed rod X, the second fixed rod Y and the third direction are perpendicular to each other.
  • the third fixing rods Z are connected in sequence, and the ultrasonic transducer D is fixedly arranged on the first fixing rod X.
  • the first fixed rod X, the second fixed rod Y, and the third fixed rod Z not only fix the ultrasonic transducer, but also realize the function of adjusting the position of the ultrasonic transducer in three different directions.
  • the fixing device may further include a base C, and the third fixing rod Z is arranged on the base C to realize the overall structural stability of the fixing device.
  • the fixing device for controlling the ultrasonic transducer sequentially moves the ultrasonic transducer to the set geometric position point in the three-dimensional detection area, including:
  • the three-dimensional position coordinates of the set geometric position points in the three-dimensional detection area are respectively determined; the three-dimensional position coordinates are mapped to the first fixed rod and the second The displacement distance of the second fixed rod and the third fixed rod; according to the displacement distance, the first fixed rod, the second fixed rod and/or the third fixed rod are adjusted to drive the ultrasonic transducer
  • the detector moves to the set geometric position point in the three-dimensional detection area.
  • the coordinates of the ultrasonic transducer to be placed are calculated.
  • the position information of the stimulation target area can be obtained according to the imaging, and then calculated by the positioning system to design the fixing of the ultrasonic transducer.
  • the effective distance between the position and the ultrasonic stimulation is obtained, and the fixed coordinates are obtained, and the three-dimensional position coordinates of the set geometric position points in the three-dimensional detection area are mapped to the displacement distance of the first fixed rod, the second fixed rod, and the third fixed rod. Fix the ultrasonic transducer.
  • connection Device B realizes the adhesion with the surface of the human body.
  • the connecting device B may be embedded outside the ultrasonic transducer, and the connecting device is filled with a conventional sound-transmitting coupling agent to ensure that the ultrasonic transmitting end of the ultrasonic transducer can be attached to the surface of the human body at any time.
  • Step 204 Perform ultrasound stimulation at the set geometric position points respectively, and obtain corresponding stimulation feedback results.
  • the stimulus feedback results can be obtained through the monitoring of electrophysiological information, such as detecting the patient’s brain electricity, ECG, myoelectricity, heart rate, body temperature, blood oxygen, blood oxygen saturation and other physiological information after ultrasound stimulation. It can be combined with some information to achieve the acquisition of stimulus feedback results.
  • electrophysiological information such as detecting the patient’s brain electricity, ECG, myoelectricity, heart rate, body temperature, blood oxygen, blood oxygen saturation and other physiological information after ultrasound stimulation. It can be combined with some information to achieve the acquisition of stimulus feedback results.
  • Step 205 Determine the target geometric position point corresponding to the target stimulus feedback result that meets the set conditions in the stimulus feedback result as the current target stimulus target point.
  • the setting conditions are formulated in advance by the doctor based on experience and the actual situation of the patient. This step is based on the stimulus feedback result to determine the current target stimulus target point in the specific shape of the three-dimensional detection area established with the current coordinates as the reference point in the ultrasonic stimulus target area.
  • Step 206 Reset the current coordinates to the coordinates of the next location point in the ultrasound stimulation target area.
  • step 202 After the execution of this step is completed, it is necessary to return to step 202, using the current coordinates in the ultrasound stimulation target area as a reference point to establish a three-dimensional detection area of a specific shape, until all the current target stimulation target points are generated, Determine a target stimulation target that meets the set conditions.
  • next location point involved in step 206 is one of the planned multiple location points in the ultrasonic stimulation target area.
  • the multiple planned locations in the ultrasonic stimulation target area may be continuous or discrete. Yes, it can be set according to actual needs.
  • the above-mentioned processing process realizes that based on the ultrasonic stimulation target area, the current target stimulation target points are respectively found from the three-dimensional detection areas established with different reference points, and then among all the current target stimulation targets generated, one that meets the set conditions is determined The target stimulates the target to realize the determination of the final optimal stimulation target.
  • Step 207 Perform an ultrasonic stimulation operation based on the target stimulation target point.
  • non-invasive ultrasound is used to accurately stimulate peripheral nerve targets in organs and other locations, and the peripheral nerves can be adjusted to achieve intervention in the patient’s disease.
  • rapid adjustments can be made through monitoring feedback Treatment plan to better improve the disease.
  • step 104 The specific implementation process of this step is the same as the implementation process of step 104 in the foregoing embodiment. In order to avoid repetition of content, it will not be repeated here.
  • the ultrasonic stimulation method in the embodiment of the present application obtains the ultrasonic stimulation target area of the organ, adjusts the fixed position of the ultrasonic transducer based on each stimulation detection point determined in the ultrasonic stimulation target area, and adjusts the fixed position of the ultrasonic transducer based on the ultrasonic stimulation at different fixed positions
  • the stimulus feedback results determine the target stimulus target point from the stimulus detection points, perform the ultrasonic stimulation operation, and realize the detection of the stimulation detection points set in the ultrasonic stimulation target area by adjusting the fixing device of the ultrasonic transducer
  • the target stimulation target point is used to improve the convenience of finding the target point and the accuracy of the ultrasonic stimulation operation when the ultrasonic device is applied to the human trunk to perform nerve stimulation.
  • FIG. 5 is a structural diagram of an ultrasonic stimulation device provided by an embodiment of the present application. For ease of description, only parts related to the embodiment of the present application are shown.
  • the ultrasonic stimulation device 300 includes: a target area acquisition module 301, a position adjustment module 302, a target point determination module 303, and an ultrasonic stimulation module 304.
  • the target area acquisition module 301 is used to acquire the ultrasonic stimulation target area of the organ;
  • the position adjustment module 302 is configured to adjust the fixed position of the ultrasonic transducer based on each stimulation detection point determined in the ultrasonic stimulation target area;
  • the target point determination module 303 is configured to determine a target stimulation target point from the stimulation detection points based on the stimulation feedback results of the ultrasonic stimulation at the different fixed positions;
  • the ultrasonic stimulation module 304 is configured to perform an ultrasonic stimulation operation based on the target stimulation target point.
  • the position adjustment module 302 includes:
  • a region establishment sub-module which is used to establish a three-dimensional detection region of a specific shape with the current coordinates in the ultrasonic stimulation target area as a reference point;
  • the control sub-module is configured to control the fixing device of the ultrasonic transducer to sequentially move the ultrasonic transducer to a set geometric position point in the three-dimensional detection area based on the three-dimensional detection area.
  • the target point determination module 303 is specifically used for:
  • the fixing device of the ultrasonic transducer includes: a first fixing rod with a function of telescoping in a first direction, a second fixing rod with a function of telescoping in a second direction, and a third fixing rod with a function of telescoping in a third direction.
  • Rod wherein the first direction, the second direction, and the third direction are perpendicular to each other, the first fixed rod, the second fixed rod, and the third fixed rod are connected in sequence, and the ultrasonic The transducer is fixedly arranged on the first fixing rod.
  • control sub-module is specifically used for:
  • the displacement distance adjust the first fixed rod, the second fixed rod and/or the third fixed rod to drive the ultrasonic transducer to move to the setting in the three-dimensional detection area Geometric location point.
  • the set geometric position point includes at least one of a vertex, a midpoint of a side, a midpoint of a plane, and a golden ratio dividing point of the side in the three-dimensional detection area of a specific shape.
  • the ultrasonic stimulation module is specifically configured to: obtain a target stimulation feedback result corresponding to the target stimulation target; according to the ultrasonic stimulation parameters that achieve the target stimulation feedback result, perform ultrasound at the target stimulation target. Stimulate operation.
  • the target area acquisition module 301 is specifically configured to: establish a three-dimensional guide map according to the medical image of the organ; and obtain the ultrasonic stimulation target area of the organ based on the selection operation of the region in the three-dimensional guide map.
  • the device also includes: a control module, a receiving module, and a result obtaining module.
  • the control module is used to control the ultrasonic transducer to emit ultrasonic waves at different fixed positions
  • a receiving module configured to receive ultrasonic echoes reflected or scattered by the nerve tissue in the different stimulation detection points
  • the result obtaining module is configured to obtain the stimulation feedback results of the ultrasound stimulation at different fixed positions based on the ultrasound echo and correspondingly collected patient physiological data.
  • the ultrasonic stimulation device in the embodiment of the present application obtains the ultrasonic stimulation target area of the organ, adjusts the fixed position of the ultrasonic transducer based on each stimulation detection point determined in the ultrasonic stimulation target area, and adjusts the fixed position of the ultrasonic transducer based on the ultrasonic stimulation at different fixed positions
  • the stimulus feedback results determine the target stimulus target point from the stimulus detection points, perform the ultrasonic stimulation operation, and realize the detection of the stimulation detection points set in the ultrasonic stimulation target area through the modulation of the fixing device of the ultrasonic transducer.
  • the target stimulation target point is used to improve the convenience of finding the target point and the accuracy of the ultrasonic stimulation operation when the ultrasonic device is applied to the human trunk to perform nerve stimulation.
  • the ultrasonic stimulation device provided by the embodiment of the present application can realize the various processes of the embodiment of the above-mentioned ultrasonic stimulation method, and can achieve the same technical effect. In order to avoid repetition, the details are not repeated here.
  • Fig. 6 is a structural diagram of a terminal provided by an embodiment of the present application.
  • the terminal 4 of this embodiment includes a processor 40, a memory 41, and a computer program 42 stored in the memory 41 and running on the processor 40.
  • the computer program 42 may be divided into one or more modules/units, and the one or more modules/units are stored in the memory 41 and executed by the processor 40 to complete This application.
  • the one or more modules/units may be a series of computer program instruction segments capable of completing specific functions, and the instruction segments are used to describe the execution process of the computer program 42 in the terminal 4.
  • the computer program 42 may be divided into a target area acquisition module, a position adjustment module, a target point determination module, an ultrasonic stimulation module, a control module, a receiving module, and a result acquisition module.
  • the specific functions of each module are as follows:
  • the target area acquisition module is used to acquire the ultrasonic stimulation target area of the organ
  • a position adjustment module for adjusting the fixed position of the ultrasonic transducer based on each stimulation detection point determined in the ultrasonic stimulation target area
  • a target point determination module configured to determine a target stimulation target point from the stimulation detection points based on the stimulation feedback results of the ultrasound stimulation at the different fixed positions
  • the ultrasonic stimulation module is used to perform an ultrasonic stimulation operation based on the target stimulation target point.
  • the position adjustment module includes:
  • a region establishment sub-module which is used to establish a three-dimensional detection region of a specific shape with the current coordinates in the ultrasonic stimulation target area as a reference point;
  • the control sub-module is configured to control the fixing device of the ultrasonic transducer to sequentially move the ultrasonic transducer to a set geometric position point in the three-dimensional detection area based on the three-dimensional detection area.
  • the target point determination module is specifically used for:
  • the fixing device of the ultrasonic transducer includes: a first fixing rod with a function of telescoping in a first direction, a second fixing rod with a function of telescoping in a second direction, and a third fixing rod with a function of telescoping in a third direction.
  • Rod wherein the first direction, the second direction, and the third direction are perpendicular to each other, the first fixed rod, the second fixed rod, and the third fixed rod are connected in sequence, and the ultrasonic The transducer is fixedly arranged on the first fixing rod.
  • control sub-module is specifically used for:
  • the displacement distance adjust the first fixed rod, the second fixed rod and/or the third fixed rod to drive the ultrasonic transducer to move to the setting in the three-dimensional detection area Geometric location point.
  • the set geometric position point includes at least one of a vertex, a midpoint of a side, a midpoint of a plane, and a golden ratio dividing point of the side in the three-dimensional detection area of a specific shape.
  • the ultrasonic stimulation module is specifically configured to: obtain a target stimulation feedback result corresponding to the target stimulation target; according to the ultrasonic stimulation parameters that achieve the target stimulation feedback result, perform ultrasound at the target stimulation target. Stimulate operation.
  • the target area acquisition module is specifically configured to: establish a three-dimensional guide map based on the medical image of the organ; and obtain the ultrasonic stimulation target area of the organ based on the selection operation of the region in the three-dimensional guide map.
  • the device also includes: a control module, a receiving module, and a result obtaining module.
  • the control module is used to control the ultrasonic transducer to emit ultrasonic waves at different fixed positions
  • a receiving module configured to receive ultrasonic echoes reflected or scattered by the nerve tissue in the different stimulation detection points
  • the result obtaining module is configured to obtain the stimulation feedback results of the ultrasound stimulation at different fixed positions based on the ultrasound echo and correspondingly collected patient physiological data.
  • the terminal 4 may include, but is not limited to, a processor 40 and a memory 41.
  • FIG. 6 is only an example of the terminal 4, and does not constitute a limitation on the terminal 4. It may include more or less components than shown in the figure, or a combination of certain components, or different components, such as
  • the terminal may also include input and output devices, network access devices, buses, and so on.
  • the so-called processor 40 may be a central processing unit (Central Processing Unit, CPU), it can also be other general-purpose processors, digital signal processors (Digital Signal Processor, DSP), application specific integrated circuits (Application Specific Integrated Circuit, ASIC), ready-made programmable gate array (Field-Programmable Gate Array, FPGA) or other programmable logic devices, discrete gates or transistor logic devices, discrete hardware components, etc.
  • the general-purpose processor may be a microprocessor or the processor may also be any conventional processor or the like.
  • the memory 41 may be an internal storage unit of the terminal 4, such as a hard disk or memory of the terminal 4.
  • the memory 41 may also be an external storage device of the terminal 4, such as a plug-in hard disk equipped on the terminal 4, a smart memory card (Smart Media Card, SMC), or a Secure Digital (SD) card, Flash Card, etc.
  • the memory 41 may also include both an internal storage unit of the terminal 4 and an external storage device.
  • the memory 41 is used to store the computer program and other programs and data required by the terminal.
  • the memory 41 can also be used to temporarily store data that has been output or will be output.
  • the disclosed device and method may be implemented in other ways.
  • the device embodiments described above are merely illustrative.
  • the division of the modules or units is only a logical function division. In actual implementation, there may be other division methods, for example, multiple units or components may be divided. Combined or can be integrated into another system, or some features can be ignored or not implemented.
  • the displayed or discussed mutual coupling or direct coupling or communication connection may be indirect coupling or communication connection through some interfaces, devices or units, and may be in electrical, mechanical or other forms.
  • the units described as separate components may or may not be physically separated, and the components displayed as units may or may not be physical units, that is, they may be located in one place, or they may be distributed on multiple network units. Some or all of the units may be selected according to actual needs to achieve the objectives of the solutions of the embodiments.
  • the functional units in the various embodiments of the present application may be integrated into one processing unit, or each unit may exist alone physically, or two or more units may be integrated into one unit.
  • the above-mentioned integrated unit can be implemented in the form of hardware or software functional unit.
  • the integrated module/unit is implemented in the form of a software functional unit and sold or used as an independent product, it can be stored in a computer readable storage medium.
  • the present application implements all or part of the processes in the above-mentioned embodiments and methods, and can also be completed by instructing relevant hardware through a computer program.
  • the computer program can be stored in a computer-readable storage medium. When the program is executed by the processor, it can implement the steps of the foregoing method embodiments.
  • the computer program includes computer program code, and the computer program code may be in the form of source code, object code, executable file, or some intermediate forms.
  • the computer-readable medium may include: any entity or device capable of carrying the computer program code, recording medium, U disk, mobile hard disk, magnetic disk, optical disk, computer memory, read-only memory (ROM, Read-Only Memory), random access memory (RAM, Random Access Memory), electrical carrier signals, telecommunications signals, and software distribution media.
  • ROM Read-Only Memory
  • RAM Random Access Memory
  • electrical carrier signals telecommunications signals
  • software distribution media any entity or device capable of carrying the computer program code
  • recording medium U disk, mobile hard disk, magnetic disk, optical disk, computer memory, read-only memory (ROM, Read-Only Memory), random access memory (RAM, Random Access Memory), electrical carrier signals, telecommunications signals, and software distribution media.

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Abstract

一种超声刺激方法及装置，适用于医疗技术领域，其中方法包括：获取器官的超声刺激靶区（101）；基于由超声刺激靶区中确定的每一刺激探测点，调整超声换能器的固定位置（102）；基于不同的固定位置处超声刺激的刺激反馈结果，从刺激探测点中确定目标刺激靶点（103）；基于目标刺激靶点，执行超声刺激操作（104），提升寻找靶点的便捷度，及提升超声刺激操作的准确度。

Description

一种超声刺激方法及装置 技术领域
本申请属于医疗技术领域，尤其涉及一种超声刺激方法及装置。
 背景技术
物理性的神经调控技术是一类应用于神经科学研究与神经疾病干预重要手段。利用电、磁、光等基本原理与神经科学相结合产生了深部脑电刺激、经颅磁刺激、光基因调控等神经刺激与调控技术。
其中，医学超声作为一种无创诊疗技术，能够在人体内形成聚焦，靶向作用于特定区域组织，具备调控外周神经的功能。
但是现在的医学超声装置通常是应用于脑部神经刺激，而在将其应用至人体躯干部位实施神经刺激时，则存在不容易寻找靶点，刺激定位不准的问题。
 技术问题
本申请实施例提供了一种超声刺激方法及装置，以解决现有技术中将医学超声装置应用至人体躯干部位实施神经刺激时，存在的不容易寻找靶点，刺激定位不准的问题。
 技术解决方案
为解决上述技术问题，本申请实施例采用的技术方案是：
本申请实施例的第一方面提供了一种超声刺激方法，包括：
获取器官的超声刺激靶区；
基于由所述超声刺激靶区中确定的每一刺激探测点，调整超声换能器的固定位置；
基于不同的所述固定位置处超声刺激的刺激反馈结果，从所述刺激探测点中确定目标刺激靶点；
基于所述目标刺激靶点，执行超声刺激操作。
本申请实施例的第二方面提供了一种超声刺激装置，包括：
获取模块，用于获取器官的超声刺激靶区；
位置调整模块，用于基于由所述超声刺激靶区中确定的每一刺激探测点，调整超声换能器的固定位置；
靶点确定模块，用于基于不同的所述固定位置处超声刺激的刺激反馈结果，从所述刺激探测点中确定目标刺激靶点；
超声刺激模块，用于基于所述目标刺激靶点，执行超声刺激操作。
本申请实施例的第三方面提供了一种终端，包括存储器、处理器以及存储在所述存储器中并可在所述处理器上运行的计算机程序，所述处理器执行所述计算机程序时实现如第一方面所述方法的步骤。
本申请实施例的第四方面提供了一种计算机可读存储介质，所述计算机可读存储介质存储有计算机程序，所述计算机程序被处理器执行时实现如第一方面所述方法的步骤。
本申请的第五方面提供了一种计算机程序产品，所述计算机程序产品包括计算机程序，所述计算机程序被一个或多个处理器执行时实现如上述第一方面所述方法的步骤。
 有益效果
本申请实施例中，获取器官的超声刺激靶区，基于由超声刺激靶区中确定的每一刺激探测点，调整超声换能器的固定位置，基于不同的固定位置处超声刺激的刺激反馈结果，从刺激探测点中确定目标刺激靶点，执行超声刺激操作，通过对超声换能器的固定装置的调变，实现从超声刺激靶区设置的刺激探测点中找出符合要求的目标刺激靶点，以在将超声装置应用至人体躯干部位实施神经刺激时，提升寻找靶点的便捷度，及提升超声刺激操作的准确度。
 附图说明
为了更清楚地说明本申请实施例中的技术方案，下面将对实施例或现有技术描述中所需要使用的附图作简单地介绍，显而易见地，下面描述中的附图仅仅是本申请的一些实施例，对于本领域普通技术人员来讲，在不付出创造性劳动性的前提下，还可以根据这些附图获得其他的附图。
图1是本申请实施例提供的一种超声刺激方法的流程图一；
图2是本申请实施例提供的一种超声刺激方法的流程图二；
图3是本申请实施例提供的三维探测区域中设定几何位置点的示意图；
图4是本申请实施例提供的超声换能器的固定装置的结构图；
图5是本申请实施例提供的一种超声刺激装置的结构图；
图6是本申请实施例提供的一种终端的结构图。
 本发明的实施方式
以下描述中，为了说明而不是为了限定，提出了诸如特定系统结构、技术之类的具体细节，以便透彻理解本申请实施例。然而，本领域的技术人员应当清楚，在没有这些具体细节的其它实施例中也可以实现本申请。在其它情况中，省略对众所周知的系统、装置、电路以及方法的详细说明，以免不必要的细节妨碍本申请的描述。
应当理解，当在本说明书和所附权利要求书中使用时，术语“包括”指示所描述特征、整体、步骤、操作、元素和/或组件的存在，但并不排除一个或多个其它特征、整体、步骤、操作、元素、组件和/或其集合的存在或添加。
还应当理解，在此本申请说明书中所使用的术语仅仅是出于描述特定实施例的目的而并不意在限制本申请。如在本申请说明书和所附权利要求书中所使用的那样，除非上下文清楚地指明其它情况，否则单数形式的“一”、“一个”及“该”意在包括复数形式。
还应当进一步理解，在本申请说明书和所附权利要求书中使用的术语“和/或”是指相关联列出的项中的一个或多个的任何组合以及所有可能组合，并且包括这些组合。
如在本说明书和所附权利要求书中所使用的那样，术语“如果”可以依据上下文被解释为“当...时”或“一旦”或“响应于确定”或“响应于检测到”。类似地，短语“如果确定”或“如果检测到[所描述条件或事件]”可以依据上下文被解释为意指“一旦确定”或“响应于确定”或“一旦检测到[所描述条件或事件]”或“响应于检测到[所描述条件或事件]”。
具体实现中，本申请实施例中描述的终端包括但不限于诸如具有触摸敏感表面(例如，触摸屏显示器和/或触摸板)的移动电话、膝上型计算机或平板计算机之类的其它便携式设备。还应当理解的是，在某些实施例中，所述设备并非便携式通信设备，而是具有触摸敏感表面(例如，触摸屏显示器和/或触摸板)的台式计算机。
在接下来的讨论中，描述了包括显示器和触摸敏感表面的终端。然而，应当理解的是，终端可以包括诸如物理键盘、鼠标和/或控制杆的一个或多个其它物理用户接口设备。
终端支持各种应用程序，例如以下中的一个或多个：绘图应用程序、演示应用程序、文字处理应用程序、网站创建应用程序、盘刻录应用程序、电子表格应用程序、游戏应用程序、电话应用程序、视频会议应用程序、电子邮件应用程序、即时消息收发应用程序、锻炼支持应用程序、照片管理应用程序、数码相机应用程序、数字摄影机应用程序、web浏览应用程序、数字音乐播放器应用程序和/或数字视频播放器应用程序。
可以在终端上执行的各种应用程序可以使用诸如触摸敏感表面的至少一个公共物理用户接口设备。可以在应用程序之间和/或相应应用程序内调整和/或改变触摸敏感表面的一个或多个功能以及终端上显示的相应信息。这样，终端的公共物理架构(例如，触摸敏感表面)可以支持具有对用户而言直观且透明的用户界面的各种应用程序。
应理解，本实施例中各步骤的序号的大小并不意味着执行顺序的先后，各过程的执行顺序应以其功能和内在逻辑确定，而不应对本申请实施例的实施过程构成任何限定。
为了说明本申请所述的技术方案，下面通过具体实施例来进行说明。
参见图1，图1是本申请实施例提供的一种超声刺激方法的流程图一。如图1所示，一种超声刺激方法，该方法包括以下步骤：
步骤101，获取器官的超声刺激靶区。
该超声刺激方法为外周神经刺激的手段，可应用于不同器官的外周神经刺激，包括：心脏、脾脏、肝脏、胰腺、胆囊等，通过刺激不同器官靶点干预相关疾病。
作为一可选的实施方式，其中，该获取器官的超声刺激靶区包括：
根据所述器官的医学图像建立三维引导图；基于对所述三维引导图中区域的选取操作，获取器官的超声刺激靶区。
具体地，该医学图像可以是例如超声图像、磁共振图像、电子计算机断层扫描图像等，装置根据医学图像建立三维引导图，操作者（医生）根据三维引导图中的信息（影像形态，或相关功能信息等）确定刺激区域，实施区域选取操作，该选取操作包括但不限于：在三维引导图中的点击操作、拖动操作、在显示屏幕上的触摸手势组合操作等。
步骤102，基于由所述超声刺激靶区中确定的每一刺激探测点，调整超声换能器的固定位置。
超声换能器可以实现将输入的电功率转换成超声波传递出去，及将接收到的超声波转换成电信号。
在基于选取操作获得超声刺激靶区之后，可以在该超声刺激靶区基础上确定该靶区内的刺激探测点，该刺激探测点为至少一个。刺激探测点用于在超声换能器固定位置调节的基础上进行超声刺激探测。在对不同的刺激探测点进行超声刺激探测时，需要基于每一刺激探测点的位置，调节超声换能器的固定位置，以改变超声换能器的超声发出位置，从超声刺激靶区中最终确定一个最优超声刺激靶点。
具体地，可实施地，由于医学影像能观察脏器形态，可以引导超声换能器的三维固定装置，将超声换能器移至刺激的靶区（较大范围），对于有些靶点较少的干预情况，需要进一步搜索最优刺激靶点。
作为一可选的实施方式，其中，所述基于不同的所述固定位置处超声刺激的刺激反馈结果，从所述刺激探测点中确定目标刺激靶点之前，还包括：
控制超声换能器在不同的固定位置处发射超声波；接收由不同的所述刺激探测点中神经组织反射或散射的超声回波；基于所述超声回波及对应采集的病患生理数据，获取不同的所述固定位置处超声刺激的刺激反馈结果。
在执行基于由所述超声刺激靶区中确定的每一刺激探测点，调整超声换能器的固定位置的过程中，每调整一次超声换能器的固定位置，就会执行一次控制超声换能器发射超声波进行超声刺激的操作过程，实现在不同的固定位置处发射超声波，以进行超声刺激探测。同时，每在一个固定位置处发射超声波，就会采集对应的超声回波及采集对应的病患生理数据，以实现对当前固定位置处进行超声刺激的刺激结果反馈信息的获取。
其中，超声回波可以用于实现刺激后对刺激部位的成像显示，用于医生或操作人员进行实施观测，并结合对应采集到的病患生理数据进行刺激结果的判断。
具体地，在实施过程中，超声换能器在实现超声刺激时，通过电子控制系统能够设置超声刺激参数，包括：超声频率、脉冲持续时间、基波频率、基波个数脉冲长度、脉冲个数、脉冲重复频率、强度等，该超声刺激参数，可以是依据患者病情信息（例如患者疾病类型、病情严重性等）、刺激探测点所在脏器的病理参数（例如脏器大小、所处深度等）来实现确定。在确定好超声刺激参数时，可以实现在不同的刺激探测点进行超声刺激。
步骤103，基于不同的所述固定位置处超声刺激的刺激反馈结果，从所述刺激探测点中确定目标刺激靶点。
该过程将不同固定位置处超声刺激的刺激反馈结果进行比较，找到刺激反馈结果最佳的一个刺激反馈结果，进而得到与该最佳刺激反馈结果相对应的最佳固定位置，与该最佳固定位置相对应的刺激探测点则确定为目标刺激靶点。
具体地，刺激反馈结果的获取可以通过电生理信息的监测来获取，例如检测超声刺激后病患的脑电、心电、肌电、心率、体温、血氧、血氧饱和度等生理信息，可以结合给些信息实现对刺激反馈结果的获取。
结合刺激反馈结果、不同固定位置及刺激探测点的调变，实现闭环监控，利用固定装置实现超声换能器的固定位置的调变，搜索并确定出最佳的精确刺激靶点。
步骤104，基于所述目标刺激靶点，执行超声刺激操作。
在找出目标刺激靶点时，即可以该目标刺激靶点为目标进行超声刺激。该操作刺激操作具体为控制超声换能器朝向目标刺激靶点发射超声波。其中，该目标刺激靶点对应于最优刺激反馈效果。或者对应于操作人员所设定的符合设定要求的刺激反馈效果。
其中，作为一可选的实施方式，所述基于所述目标刺激靶点，执行超声刺激操作，包括：
获取所述目标刺激靶点所对应的目标刺激反馈结果；依照达到所述目标刺激反馈结果的超声刺激参数，在所述目标刺激靶点处，执行超声刺激操作。
实现依照最佳刺激反馈效果所对应的超声刺激参数，对目标刺激靶点进行超声刺激。需要说明的是，该实施方式可以根据实际需要进行实际设置，不以此处为限。
本申请实施例中的超声刺激方法，获取器官的超声刺激靶区，基于由超声刺激靶区中确定的每一刺激探测点，调整超声换能器的固定位置，基于不同的固定位置处超声刺激的刺激反馈结果，从刺激探测点中确定目标刺激靶点，执行超声刺激操作，通过对超声换能器的固定装置的调变，实现从超声刺激靶区设置的刺激探测点中找出符合要求的目标刺激靶点，以在将超声装置应用至人体躯干部位实施神经刺激时，提升寻找靶点的便捷度，及提升超声刺激操作的准确度。
本申请实施例中还提供了超声刺激方法的不同实施方式。
参见图2，图2是本申请实施例提供的一种超声刺激方法的流程图二。如图2所示，一种超声刺激方法，该方法包括以下步骤：
步骤201，获取器官的超声刺激靶区。
该超声刺激方法为外周神经刺激的手段，可应用于不同器官的外周神经刺激，包括：心脏、脾脏、肝脏、胰腺、胆囊等，通过刺激不同器官靶点干预相关疾病。
此外，该步骤的具体实现过程与前述实施方式中步骤101的实现过程相同，为避免内容重复，此处不再赘述。
步骤202，以所述超声刺激靶区中的当前坐标为参照点，建立特定形状的三维探测区域。
在基于由超声刺激靶区中确定的每一刺激探测点，调整超声换能器的固定位置的过程中，需要对超声刺激靶区中的刺激点进行遍历。具体地，先以超声刺激靶区中的某一坐标为参照点，建立起与该一坐标相对应的三维探测区，在该三维探测区中执行一次探测点的遍历性超声刺激探测过程。
其中，该特定形状可以是立方体形、长方体形、球形等形状。
步骤203，基于所述三维探测区域，控制超声换能器的固定装置依次移动所述超声换能器至所述三维探测区域中的设定几何位置点。
其中，该设定几何位置点包括特定形状的所述三维探测区域中的顶点、边的中点、平面中点及边的黄金比例分割点中的至少一项。
结合图3所示，当三维探测区域的特定形状为正立方体形时，设定的几何位置点如图中黑点所示。
在建立起的三维探测区域中进行遍历性超声刺激探测时，需要通过控制超声换能器的固定装置依次移动超声换能器来实现在设定几何位置点处的遍历操作过程。
具体地，结合图4所示，该超声换能器的固定装置包括：具有沿第一方向伸缩功能的第一固定杆X、具有沿第二方向伸缩功能的第二固定杆Y及具有沿第三方向伸缩功能的第三固定杆Z，其中，所述第一方向、所述第二方向及所述第三方向互相垂直，所述第一固定杆X、所述第二固定杆Y及所述第三固定杆Z依次连接，所述超声换能器D固定设置于所述第一固定杆X上。
该第一固定杆X、第二固定杆Y及第三固定杆Z在起到对超声换能器进行固定的同时，还实现在三个不同方向上对超声换能器进行位置调节的作用。
该固定装置还可以包括底座C，将第三固定杆Z设置于底座C上，实现固定装置的整体结构稳定性。
对应地，所述控制超声换能器的固定装置依次移动所述超声换能器至所述三维探测区域中的设定几何位置点，包括：
基于所述超声刺激靶区中的当前坐标，分别确定所述三维探测区域中所述设定几何位置点的三维位置坐标；将所述三维位置坐标映射至所述第一固定杆、所述第二固定杆及所述第三固定杆的位移距离；按照所述位移距离，调整所述第一固定杆、所述第二固定杆和/或所述第三固定杆，带动所述超声换能器移动至所述三维探测区域中的所述设定几何位置点处。
该过程中，具体根据超声换能器与超声刺激靶区的相对位置，及结合三维探测区域中所述设定几何位置点的三维位置坐标，计算超声换能器的应放置坐标。
具体地，该步骤中，在通过超声换能器的固定装置进行超声换能器的位置调整时，可以是根据成像获得刺激靶区的位置信息后，通过定位系统计算，设计超声换能器固定位置与超声刺激的有效距离，获得固定坐标，实现将三维探测区域中设定几何位置点的三维位置坐标映射至第一固定杆、第二固定杆及第三固定杆的位移距离，利用固定器固定超声换能器。
此外，需要说明的是，结合图4所示，当在通过超声换能器的固定装置进行超声换能器的位置调整过程中，如果超声换能器与人体表面之间存在间隙时，需要在超声换能器与人体之间匹配相应尺寸的衔接装置B。
该种情况可能发生于，当病患躺在病床A上时，超声换能器的高度调节之后，人体表面与超声换能器之间有空隙，超声无法穿透空气，利用高度可调节的衔接装置B，实现与人体表面之间的贴合。具体地，衔接装置B可以是嵌在超声换能器外部，衔接装置中填充常规透声耦合剂，随时保证超声换能器的超声发射端能够与人体表面贴合。
步骤204，分别在所述设定几何位置点进行超声刺激，并获取对应的刺激反馈结果。
具体地，刺激反馈结果的获取可以通过电生理信息的监测来获取，例如检测超声刺激后病患的脑电、心电、肌电、心率、体温、血氧、血氧饱和度等生理信息，可以结合给些信息实现对刺激反馈结果的获取。
步骤205，将所述刺激反馈结果中符合设定条件的目标刺激反馈结果所对应的目标几何位置点确定为当前目标刺激靶点。
该设定条件为医生根据经验结合病患实际情况进行提前制定。该步骤基于刺激反馈结果实现对超声刺激靶区中以当前坐标为参照点所建立的特定形状的三维探测区域中的当前目标刺激靶点的确定。
步骤206，将所述当前坐标重置为所述超声刺激靶区中的下一位置点的坐标。
在该步骤执行完成后，需要返回执行步骤202，以所述超声刺激靶区中的当前坐标为参照点，建立特定形状的三维探测区域，直至在产生的所有所述当前目标刺激靶点中，确定一个符合设定条件的目标刺激靶点。
其中，步骤206中所涉及的下一位置点为超声刺激靶区中规划好的多个位置点中的一个，超声刺激靶区中规划好的多个位置点可以是连续的，也可以是离散的，可以根据实际需要进行设置。
上述处理过程，实现基于超声刺激靶区，从以不同参照点建立的三维探测区域中分别找出当前目标刺激靶点，再在产生的所有当前目标刺激靶点中，确定一个符合设定条件的目标刺激靶点，实现最终最佳刺激靶点的确定。
步骤207，基于所述目标刺激靶点，执行超声刺激操作。
在具体执行超声刺激的过程中，使用无创超声精准的刺激在器官等位置的外周神经靶点，通过调控外周神经实现对患者疾病的干预，外周神经调控过程中，通过监控的反馈，快速得调整治疗方案，从而更好改善患病。
该步骤的具体实现过程与前述实施方式中步骤104的实现过程相同，为避免内容重复，此处不再赘述。
本申请实施例中的超声刺激方法，获取器官的超声刺激靶区，基于由超声刺激靶区中确定的每一刺激探测点，调整超声换能器的固定位置，基于不同的固定位置处超声刺激的刺激反馈结果，从刺激探测点中确定目标刺激靶点，执行超声刺激操作，通过对超声换能器的固定装置的调变，实现从超声刺激靶区设置的刺激探测点中找出符合要求的目标刺激靶点，以在将超声装置应用至人体躯干部位实施神经刺激时，提升寻找靶点的便捷度，及提升超声刺激操作的准确度。
参见图5，图5是本申请实施例提供的一种超声刺激装置的结构图，为了便于说明，仅示出了与本申请实施例相关的部分。
所述超声刺激装置300包括：靶区获取模块301、位置调整模块302、靶点确定模块303及超声刺激模块304。
靶区获取模块301，用于获取器官的超声刺激靶区；
位置调整模块302，用于基于由所述超声刺激靶区中确定的每一刺激探测点，调整超声换能器的固定位置；
靶点确定模块303，用于基于不同的所述固定位置处超声刺激的刺激反馈结果，从所述刺激探测点中确定目标刺激靶点；
超声刺激模块304，用于基于所述目标刺激靶点，执行超声刺激操作。
其中，位置调整模块302包括：
区域建立子模块，用于以所述超声刺激靶区中的当前坐标为参照点，建立特定形状的三维探测区域；
控制子模块，用于基于所述三维探测区域，控制超声换能器的固定装置依次移动所述超声换能器至所述三维探测区域中的设定几何位置点。
其中，所述靶点确定模块303具体用于：
分别在所述设定几何位置点进行超声刺激，并获取对应的刺激反馈结果；
将所述刺激反馈结果中符合设定条件的目标刺激反馈结果所对应的目标几何位置点确定为当前目标刺激靶点；
将所述当前坐标重置为所述超声刺激靶区中的下一位置点的坐标，并返回执行所述以所述超声刺激靶区中的当前坐标为参照点，建立特定形状的三维探测区域的步骤，直至在产生的所有所述当前目标刺激靶点中，确定一个符合设定条件的所述目标刺激靶点。
其中，所述超声换能器的固定装置包括：具有沿第一方向伸缩功能的第一固定杆、具有沿第二方向伸缩功能的第二固定杆及具有沿第三方向伸缩功能的第三固定杆，其中，所述第一方向、所述第二方向及所述第三方向互相垂直，所述第一固定杆、所述第二固定杆及所述第三固定杆依次连接，所述超声换能器固定设置于所述第一固定杆上。
其中，所述控制子模块具体用于：
基于所述超声刺激靶区中的当前坐标，分别确定所述三维探测区域中所述设定几何位置点的三维位置坐标；
将所述三维位置坐标映射至所述第一固定杆、所述第二固定杆及所述第三固定杆的位移距离；
按照所述位移距离，调整所述第一固定杆、所述第二固定杆和/或所述第三固定杆，带动所述超声换能器移动至所述三维探测区域中的所述设定几何位置点处。
其中，所述设定几何位置点包括特定形状的所述三维探测区域中的顶点、边的中点、平面中点及边的黄金比例分割点中的至少一项。
其中，所述超声刺激模块具体用于：获取所述目标刺激靶点所对应的目标刺激反馈结果；依照达到所述目标刺激反馈结果的超声刺激参数，在所述目标刺激靶点处，执行超声刺激操作。
其中，所述靶区获取模块301具体用于：根据所述器官的医学图像建立三维引导图；基于对所述三维引导图中区域的选取操作，获取器官的超声刺激靶区。
该装置还包括：控制模块、接收模块及结果获取模块。
控制模块，用于控制超声换能器在不同的固定位置处发射超声波；
接收模块，用于接收由不同的所述刺激探测点中神经组织反射或散射的超声回波；
结果获取模块，用于基于所述超声回波及对应采集的病患生理数据，获取不同的所述固定位置处超声刺激的刺激反馈结果。
本申请实施例中的超声刺激装置，获取器官的超声刺激靶区，基于由超声刺激靶区中确定的每一刺激探测点，调整超声换能器的固定位置，基于不同的固定位置处超声刺激的刺激反馈结果，从刺激探测点中确定目标刺激靶点，执行超声刺激操作，通过对超声换能器的固定装置的调变，实现从超声刺激靶区设置的刺激探测点中找出符合要求的目标刺激靶点，以在将超声装置应用至人体躯干部位实施神经刺激时，提升寻找靶点的便捷度，及提升超声刺激操作的准确度。
本申请实施例提供的超声刺激装置能够实现上述超声刺激方法的实施例的各个过程，且能达到相同的技术效果，为避免重复，这里不再赘述。
图6是本申请实施例提供的一种终端的结构图。如该图所示，该实施例的终端4包括：处理器40、存储器41以及存储在所述存储器41中并可在所述处理器40上运行的计算机程序42。
示例性的，所述计算机程序42可以被分割成一个或多个模块/单元，所述一个或者多个模块/单元被存储在所述存储器41中，并由所述处理器40执行，以完成本申请。所述一个或多个模块/单元可以是能够完成特定功能的一系列计算机程序指令段，该指令段用于描述所述计算机程序42在所述终端4中的执行过程。例如，所述计算机程序42可以被分割成靶区获取模块、位置调整模块、靶点确定模块、超声刺激模块、控制模块、接收模块及结果获取模块。各模块具体功能如下：
靶区获取模块，用于获取器官的超声刺激靶区；
位置调整模块，用于基于由所述超声刺激靶区中确定的每一刺激探测点，调整超声换能器的固定位置；
靶点确定模块，用于基于不同的所述固定位置处超声刺激的刺激反馈结果，从所述刺激探测点中确定目标刺激靶点；
超声刺激模块，用于基于所述目标刺激靶点，执行超声刺激操作。
其中，位置调整模块包括：
区域建立子模块，用于以所述超声刺激靶区中的当前坐标为参照点，建立特定形状的三维探测区域；
控制子模块，用于基于所述三维探测区域，控制超声换能器的固定装置依次移动所述超声换能器至所述三维探测区域中的设定几何位置点。
其中，所述靶点确定模块具体用于：
分别在所述设定几何位置点进行超声刺激，并获取对应的刺激反馈结果；
将所述刺激反馈结果中符合设定条件的目标刺激反馈结果所对应的目标几何位置点确定为当前目标刺激靶点；
将所述当前坐标重置为所述超声刺激靶区中的下一位置点的坐标，并返回执行所述以所述超声刺激靶区中的当前坐标为参照点，建立特定形状的三维探测区域的步骤，直至在产生的所有所述当前目标刺激靶点中，确定一个符合设定条件的所述目标刺激靶点。
其中，所述超声换能器的固定装置包括：具有沿第一方向伸缩功能的第一固定杆、具有沿第二方向伸缩功能的第二固定杆及具有沿第三方向伸缩功能的第三固定杆，其中，所述第一方向、所述第二方向及所述第三方向互相垂直，所述第一固定杆、所述第二固定杆及所述第三固定杆依次连接，所述超声换能器固定设置于所述第一固定杆上。
其中，所述控制子模块具体用于：
基于所述超声刺激靶区中的当前坐标，分别确定所述三维探测区域中所述设定几何位置点的三维位置坐标；
将所述三维位置坐标映射至所述第一固定杆、所述第二固定杆及所述第三固定杆的位移距离；
按照所述位移距离，调整所述第一固定杆、所述第二固定杆和/或所述第三固定杆，带动所述超声换能器移动至所述三维探测区域中的所述设定几何位置点处。
其中，所述设定几何位置点包括特定形状的所述三维探测区域中的顶点、边的中点、平面中点及边的黄金比例分割点中的至少一项。
其中，所述超声刺激模块具体用于：获取所述目标刺激靶点所对应的目标刺激反馈结果；依照达到所述目标刺激反馈结果的超声刺激参数，在所述目标刺激靶点处，执行超声刺激操作。
其中，所述靶区获取模块具体用于：根据所述器官的医学图像建立三维引导图；基于对所述三维引导图中区域的选取操作，获取器官的超声刺激靶区。
该装置还包括：控制模块、接收模块及结果获取模块。
控制模块，用于控制超声换能器在不同的固定位置处发射超声波；
接收模块，用于接收由不同的所述刺激探测点中神经组织反射或散射的超声回波；
结果获取模块，用于基于所述超声回波及对应采集的病患生理数据，获取不同的所述固定位置处超声刺激的刺激反馈结果。
所述终端4可包括，但不仅限于，处理器40、存储器41。本领域技术人员可以理解，图6仅仅是终端4的示例，并不构成对终端4的限定，可以包括比图示更多或更少的部件，或者组合某些部件，或者不同的部件，例如所述终端还可以包括输入输出设备、网络接入设备、总线等。
所称处理器40可以是中央处理单元(Central Processing Unit，CPU)，还可以是其他通用处理器、数字信号处理器(Digital Signal Processor，DSP)、专用集成电路(Application Specific Integrated Circuit，ASIC)、现成可编程门阵列(Field-Programmable Gate Array，FPGA) 或者其他可编程逻辑器件、分立门或者晶体管逻辑器件、分立硬件组件等。通用处理器可以是微处理器或者该处理器也可以是任何常规的处理器等。
所述存储器41可以是所述终端4的内部存储单元，例如终端4的硬盘或内存。所述存储器41也可以是所述终端4的外部存储设备，例如所述终端4上配备的插接式硬盘，智能存储卡（Smart Media Card，SMC），安全数字（Secure Digital，SD）卡，闪存卡（Flash Card）等。其中，所述存储器41还可以既包括所述终端4的内部存储单元也包括外部存储设备。所述存储器41用于存储所述计算机程序以及所述终端所需的其他程序和数据。所述存储器41还可以用于暂时地存储已经输出或者将要输出的数据。
所属领域的技术人员可以清楚地了解到，为了描述的方便和简洁，仅以上述各功能单元、模块的划分进行举例说明，实际应用中，可以根据需要而将上述功能分配由不同的功能单元、模块完成，即将所述装置的内部结构划分成不同的功能单元或模块，以完成以上描述的全部或者部分功能。实施例中的各功能单元、模块可以集成在一个处理单元中，也可以是各个单元单独物理存在，也可以两个或两个以上单元集成在一个单元中，上述集成的单元既可以采用硬件的形式实现，也可以采用软件功能单元的形式实现。另外，各功能单元、模块的具体名称也只是为了便于相互区分，并不用于限制本申请的保护范围。上述系统中单元、模块的具体工作过程，可以参考前述方法实施例中的对应过程，在此不再赘述。
在上述实施例中，对各个实施例的描述都各有侧重，某个实施例中没有详述或记载的部分，可以参见其它实施例的相关描述。
本领域普通技术人员可以意识到，结合本文中所公开的实施例描述的各示例的单元及算法步骤，能够以电子硬件、或者计算机软件和电子硬件的结合来实现。这些功能究竟以硬件还是软件方式来执行，取决于技术方案的特定应用和设计约束条件。专业技术人员可以对每个特定的应用来使用不同方法来实现所描述的功能，但是这种实现不应认为超出本申请的范围。
在本申请所提供的实施例中，应该理解到，所揭露的装置和方法，可以通过其它的方式实现。例如，以上所描述的装置实施例仅仅是示意性的，例如，所述模块或单元的划分，仅仅为一种逻辑功能划分，实际实现时可以有另外的划分方式，例如多个单元或组件可以结合或者可以集成到另一个系统，或一些特征可以忽略，或不执行。另一点，所显示或讨论的相互之间的耦合或直接耦合或通讯连接可以是通过一些接口，装置或单元的间接耦合或通讯连接，可以是电性，机械或其它的形式。
所述作为分离部件说明的单元可以是或者也可以不是物理上分开的，作为单元显示的部件可以是或者也可以不是物理单元，即可以位于一个地方，或者也可以分布到多个网络单元上。可以根据实际的需要选择其中的部分或者全部单元来实现本实施例方案的目的。
另外，在本申请各个实施例中的各功能单元可以集成在一个处理单元中，也可以是各个单元单独物理存在，也可以两个或两个以上单元集成在一个单元中。上述集成的单元既可以采用硬件的形式实现，也可以采用软件功能单元的形式实现。
所述集成的模块/单元如果以软件功能单元的形式实现并作为独立的产品销售或使用时，可以存储在一个计算机可读取存储介质中。基于这样的理解，本申请实现上述实施例方法中的全部或部分流程，也可以通过计算机程序来指令相关的硬件来完成，所述的计算机程序可存储于一计算机可读存储介质中，该计算机程序在被处理器执行时，可实现上述各个方法实施例的步骤。其中，所述计算机程序包括计算机程序代码，所述计算机程序代码可以为源代码形式、对象代码形式、可执行文件或某些中间形式等。所述计算机可读介质可以包括：能够携带所述计算机程序代码的任何实体或装置、记录介质、U盘、移动硬盘、磁碟、光盘、计算机存储器、只读存储器（ROM，Read-Only Memory）、随机存取存储器（RAM，Random Access Memory）、电载波信号、电信信号以及软件分发介质等。需要说明的是，所述计算机可读介质包含的内容可以根据司法管辖区内立法和专利实践的要求进行适当的增减，例如在某些司法管辖区，根据立法和专利实践，计算机可读介质不包括电载波信号和电信信号。
以上所述实施例仅用以说明本申请的技术方案，而非对其限制；尽管参照前述实施例对本申请进行了详细的说明，本领域的普通技术人员应当理解：其依然可以对前述各实施例所记载的技术方案进行修改，或者对其中部分技术特征进行等同替换；而这些修改或者替换，并不使相应技术方案的本质脱离本申请各实施例技术方案的精神和范围，均应包含在本申请的保护范围之内。

Claims (12)

  1. 一种超声刺激方法，其特征在于，包括：
    获取器官的超声刺激靶区；
    基于由所述超声刺激靶区中确定的每一刺激探测点，调整超声换能器的固定位置；
    基于不同的所述固定位置处超声刺激的刺激反馈结果，从所述刺激探测点中确定目标刺激靶点；
    基于所述目标刺激靶点，执行超声刺激操作。
  2. 根据权利要求1所述的超声刺激方法，其特征在于，所述基于由所述超声刺激靶区中确定的每一刺激探测点，调整超声换能器的固定位置，包括：
    以所述超声刺激靶区中的当前坐标为参照点，建立特定形状的三维探测区域；
    基于所述三维探测区域，控制超声换能器的固定装置依次移动所述超声换能器至所述三维探测区域中的设定几何位置点。
  3. 根据权利要求2所述的超声刺激方法，其特征在于，
    所述基于不同的所述固定位置处超声刺激的刺激反馈结果，从所述刺激探测点中确定目标刺激靶点，包括：
    分别在所述设定几何位置点进行超声刺激，并获取对应的刺激反馈结果；
    将所述刺激反馈结果中符合设定条件的目标刺激反馈结果所对应的目标几何位置点确定为当前目标刺激靶点；
    将所述当前坐标重置为所述超声刺激靶区中的下一位置点的坐标，并返回执行所述以所述超声刺激靶区中的当前坐标为参照点，建立特定形状的三维探测区域的步骤，直至在产生的所有所述当前目标刺激靶点中，确定一个符合设定条件的所述目标刺激靶点。
  4. 根据权利要求2所述的超声刺激方法，其特征在于，所述超声换能器的固定装置包括：具有沿第一方向伸缩功能的第一固定杆、具有沿第二方向伸缩功能的第二固定杆及具有沿第三方向伸缩功能的第三固定杆，其中，所述第一方向、所述第二方向及所述第三方向互相垂直，所述第一固定杆、所述第二固定杆及所述第三固定杆依次连接，所述超声换能器固定设置于所述第一固定杆上。
  5. 根据权利要求4所述的超声刺激方法，其特征在于，
    所述控制超声换能器的固定装置依次移动所述超声换能器至所述三维探测区域中的设定几何位置点，包括：
    基于所述超声刺激靶区中的当前坐标，分别确定所述三维探测区域中所述设定几何位置点的三维位置坐标；
    将所述三维位置坐标映射至所述第一固定杆、所述第二固定杆及所述第三固定杆的位移距离；
    按照所述位移距离，调整所述第一固定杆、所述第二固定杆和/或所述第三固定杆，带动所述超声换能器移动至所述三维探测区域中的所述设定几何位置点处。
  6. 根据权利要求2所述的超声刺激方法，其特征在于，所述设定几何位置点包括特定形状的所述三维探测区域中的顶点、边的中点、平面中点及边的黄金比例分割点中的至少一项。
  7. 根据权利要求1所述的超声刺激方法，其特征在于，所述基于所述目标刺激靶点，执行超声刺激操作，包括：
    获取所述目标刺激靶点所对应的目标刺激反馈结果；
    依照达到所述目标刺激反馈结果的超声刺激参数，在所述目标刺激靶点处，执行超声刺激操作。
  8. 根据权利要求1所述的超声刺激方法，其特征在于，所述获取器官的超声刺激靶区，包括：
    根据所述器官的医学图像建立三维引导图；
    基于对所述三维引导图中区域的选取操作，获取器官的超声刺激靶区。
  9. 根据权利要求1所述的超声刺激方法，其特征在于，
    所述基于不同的所述固定位置处超声刺激的刺激反馈结果，从所述刺激探测点中确定目标刺激靶点之前，还包括：
    控制超声换能器在不同的固定位置处发射超声波；
    接收由不同的所述刺激探测点中神经组织反射或散射的超声回波；
    基于所述超声回波及对应采集的病患生理数据，获取不同的所述固定位置处超声刺激的刺激反馈结果。
  10. 一种超声刺激装置，其特征在于，包括：
    获取模块，用于获取器官的超声刺激靶区；
    位置调整模块，用于基于由所述超声刺激靶区中确定的每一刺激探测点，调整超声换能器的固定位置；
    靶点确定模块，用于基于不同的所述固定位置处超声刺激的刺激反馈结果，从所述刺激探测点中确定目标刺激靶点；
    超声刺激模块，用于基于所述目标刺激靶点，执行超声刺激操作。
  11. 一种终端，包括存储器、处理器以及存储在所述存储器中并可在所述处理器上运行的计算机程序，其特征在于，所述处理器执行所述计算机程序时实现如权利要求1至9任一项所述方法的步骤。
  12. 一种计算机可读存储介质，所述计算机可读存储介质存储有计算机程序，其特征在于，所述计算机程序被处理器执行时实现如权利要求1至9任一项所述方法的步骤。
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