WO2021027395A1 - 一种电解质分析仪的自动质控系统与方法 - Google Patents

一种电解质分析仪的自动质控系统与方法 Download PDF

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WO2021027395A1
WO2021027395A1 PCT/CN2020/096454 CN2020096454W WO2021027395A1 WO 2021027395 A1 WO2021027395 A1 WO 2021027395A1 CN 2020096454 W CN2020096454 W CN 2020096454W WO 2021027395 A1 WO2021027395 A1 WO 2021027395A1
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quality control
automatic quality
analysis system
nozzle
automatic
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French (fr)
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黄浩
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梅州康立高科技有限公司
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1004—Cleaning sample transfer devices
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1009—Characterised by arrangements for controlling the aspiration or dispense of liquids

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  • the invention relates to an electrolyte analyzer, in particular to an automatic quality control system and method of the electrolyte analyzer.
  • the current electrolyte analyzer cannot perform automatic quality control, and cannot monitor the performance of the instrument over a period of time.
  • the present invention provides an automatic quality control system and method for an electrolyte analyzer.
  • the invention provides an automatic quality control system for an electrolyte analyzer, which includes an automatic quality control package assembly, a cleaning solution package, a rotatable distribution valve, a liquid suction pump, a rotatable lifting sampling needle, a feeding nozzle, and ISE analysis System, wherein the feed nozzle includes a waste liquid device nozzle and an ISE analysis system nozzle, the automatic quality control package assembly and the cleaning solution package are respectively connected to the input end of the distribution valve, and the distribution valve
  • the output end is connected to the input end of the sampling needle through the suction pump, the ISE analysis system nozzle and the waste liquid device nozzle are all located on the movement track of the output end of the sampling needle, and the ISE analysis system is connected to The nozzle is connected with the ISE analysis system, and the output end of the nozzle of the waste liquid device is connected with a cleaning liquid waste liquid device.
  • the automatic quality control package component includes a first automatic quality control package, a second automatic quality control package, and a third automatic quality control package with different quality control requirements.
  • the first automatic quality control package, The second automatic quality control package and the third automatic quality control package are respectively connected to the input ends of the distribution valve.
  • the distribution valve is connected with a rotating mechanism, and the sampling needle is connected with a rotating lifting mechanism.
  • the ISE analysis system includes a flow cell and a quality control liquid suction pump, the input end of the flow cell is connected to the ISE analysis system connector, and the output end of the flow cell is connected to the Connect the input end of the quality control liquid suction pump.
  • the output end of the quality control liquid suction pump is connected with a quality control liquid waste liquid device.
  • the present invention also provides an automatic quality control method of an electrolyte analyzer, which is based on the automatic quality control system of any one of the above-mentioned electrolyte analyzers, and performs the following steps:
  • automatic quality control rotate the distribution valve to the output end of the automatic quality control package assembly, suck the quality control liquid from the automatic quality control package assembly through the distribution valve to the sampling needle through the suction pump, and then transfer the quality control liquid through the sampling needle Spit out to the ISE analysis system connector, and the quality control liquid is spit out through the ISE analysis system connector and input to the ISE analysis system for automatic quality control.
  • steps S1 and S2 are repeated to complete automatic tests with different quality control requirements.
  • step S2 the ISE analysis system sends the data obtained by the test to the background.
  • the beneficial effect of the present invention is that the automatic quality control of the electrolyte analyzer is realized through the above scheme, and the performance of the instrument can be monitored for a period of time.
  • Fig. 1 is a schematic diagram of an automatic quality control system of an electrolyte analyzer of the present invention.
  • Fig. 2 is a partial schematic diagram of an automatic quality control system of an electrolyte analyzer of the present invention.
  • Fig. 3 is a partial schematic diagram of an automatic quality control system of an electrolyte analyzer of the present invention.
  • an automatic quality control system for an electrolyte analyzer includes an automatic quality control package assembly, a cleaning solution package 100, a degreasing water package 114, a rotatable distribution valve 104, a suction pump 105, Rotatable lifting sampling needle 106, feed nozzle, ISE analysis system, wherein the feed nozzle includes waste liquid device nozzle 107 and ISE analysis system nozzle 110, the automatic quality control package assembly, cleaning fluid
  • the bag 100 is respectively connected to the input end of the distribution valve 104, the output end of the distribution valve 104 is connected to the input end of the sampling needle 106 through the suction pump 105, the ISE analysis system connector 110, waste
  • the nozzles 107 of the liquid device are all located on the movement track of the output end of the sampling needle 106, the nozzle 110 of the ISE analysis system is connected with the ISE analysis system, and the output end of the nozzle 107 of the waste liquid device is connected with cleaning liquid.
  • Waste liquid device 108 waste liquid device 108.
  • the automatic quality control package component includes a first automatic quality control package 101, a second automatic quality control package 102, and a third automatic quality control package 103 with different quality control requirements.
  • the automatic quality control package 101, the second automatic quality control package 102, and the third automatic quality control package 103 are respectively connected to the input end of the distribution valve 104.
  • the first automatic quality control package 101 contains a high-level quality control liquid.
  • the second automatic quality control package 102 contains a medium-level quality control solution
  • the third automatic quality control package 103 contains a low-level quality control solution.
  • the distribution valve 104 is connected with a rotating mechanism, and the sampling needle 106 is connected with a rotating lifting mechanism.
  • the rotating mechanism can be realized by a motor, and the lifting mechanism can be realized by an air cylinder.
  • the ISE analysis system includes a flow cell 111 and a quality control liquid suction pump 112.
  • the input end of the flow cell 111 is connected to the ISE analysis system connector 110.
  • the flow cell The output end of 111 is connected to the input end of the quality control liquid suction pump 112.
  • a quality control liquid waste liquid device 113 is connected to the output end of the quality control liquid suction pump 112.
  • an automatic quality control method for an electrolyte analyzer is based on the automatic quality control system of an electrolyte analyzer described in any one of the above, and the following steps are performed:
  • Automatic quality control rotate the distribution valve 104 to the output end of the automatic quality control package assembly, and suck the quality control liquid from the automatic quality control package assembly through the distribution valve 104 to the sampling needle 106 through the suction pump 105, and then pass the sampling needle 106 spit out the quality control liquid to the ISE analysis system connector 110, and the quality control liquid is spit out through the ISE analysis system connector 110 and input to the ISE analysis system for automatic quality control.
  • steps S1 and S2 are repeated to complete the automatic testing of different quality control requirements.
  • step S2 the ISE analysis system sends the data obtained by the test to the background.
  • the present invention provides an automatic quality control system and method for an electrolyte analyzer.
  • the distribution valve 104 is first rotated to the position corresponding to the cleaning solution pack 100, and then the flow path is cleaned. Then the distribution valve 104 rotates to the first automatic quality control package 101 to extract the quality control liquid, and the sampling needle 106 rotates to the top of the ISE analysis system connector 110, spit the quality control liquid into the ISE analysis system connector 110, and then the quality control liquid
  • the suction pump 112 pumps the quality control solution into the flow cell 111 of the electrolyte analyzer, and then starts the test and obtains the test data.
  • the ISE analysis system automatically cleans the flow path to prepare the next sample for testing, the flow cell 111 While acquiring the data, the sampling system returns to the initial position to perform flow path cleaning. After the cleaning is completed, the distribution valve 104 rotates to the second automatic quality control package 102 to perform operations similar to the test method of the first automatic quality control package 101. In order to complete the automatic test of high school low grade three quality control.
  • the instrument analyzes the performance of the instrument for a period of time based on the test data, and gives corresponding warnings and prompts.
  • the present invention provides an automatic quality control system and method for an electrolyte analyzer, which can automatically control quality, monitor the performance of the instrument over a period of time, and can give an early warning of the instrument so that medical personnel can obtain accurate patient diagnosis numbers. Very high clinical significance.

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Electrochemistry (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Sampling And Sample Adjustment (AREA)

Abstract

一种电解质分析仪的自动质控系统，包括自动质控包组件、清洗液包（100）、可转动的分配阀（104）、吸液泵（105）、可转动升降的采样针（106）、进料接嘴、ISE分析系统，其中，进料接嘴包括废液装置接嘴（107）和ISE分析系统接嘴（110），自动质控包组件和清洗液包（100）分别与分配阀（104）的输入端连接，分配阀（104）的输出端通过吸液泵（105）与采样针（106）的输入端连接， ISE分析系统接嘴（110）和废液装置接嘴（107）均位于采样针（106）的输出端的运动轨迹上， ISE分析系统接嘴（110）与ISE分析系统连接，废液装置接嘴（107）的输出端连接有清洗液废液装置（108）。还包括一种电解质分析仪的自动质控方法，实现了电解质分析仪的自动质控，可以监控一段时期内仪器性能的好坏。

Description

一种电解质分析仪的自动质控系统与方法 技术领域
本发明涉及电解质分析仪，尤其涉及一种电解质分析仪的自动质控系统与方法。
 背景技术
现有电解质分析仪无法进行自动质控，无法监控一段时期内仪器性能的好坏。
 技术解决方案
为了解决现有技术中的问题，本发明提供了一种电解质分析仪的自动质控系统与方法。
本发明提供了一种电解质分析仪的自动质控系统，包括自动质控包组件、清洗液包、可转动的分配阀、吸液泵、可转动升降的采样针、进料接嘴、ISE分析系统，其中，所述进料接嘴包括废液装置接嘴和ISE分析系统接嘴，所述自动质控包组件、清洗液包分别与所述分配阀的输入端连接，所述分配阀的输出端通过所述吸液泵与所述采样针的输入端连接，所述ISE分析系统接嘴、废液装置接嘴均位于所述采样针的输出端的运动轨迹上，所述ISE分析系统接嘴与所述ISE分析系统连接，所述废液装置接嘴的输出端连接有清洗液废液装置。
作为本发明的进一步改进，所述自动质控包组件包括不同质控要求的第一自动质控包、第二自动质控包和第三自动质控包，所述第一自动质控包、第二自动质控包、第三自动质控包分别与所述分配阀的输入端连接。
作为本发明的进一步改进，所述分配阀连接有旋转机构，所述采样针连接有旋转升降机构。
作为本发明的进一步改进，所述ISE分析系统包括流通池和质控液吸液泵，所述流通池的输入端与所述ISE分析系统接嘴连接，所述流通池的输出端与所述质控液吸液泵的输入端连接。
作为本发明的进一步改进，所述质控液吸液泵的输出端连接有质控液废液装置。
本发明还提供了一种电解质分析仪的自动质控方法，以上述中任一项所述的电解质分析仪的自动质控系统为基础，进行以下步骤：
S1、清洗流路，将分配阀转动到清洗液包的输出端，通过吸液泵将清洗液从清洗液包经分配阀吸至采样针，然后通过采样针将清洗液吐出至废液装置接嘴，清洗液经废液装置接嘴排出至废液装置，以清洗流路；
S2、自动质控，将分配阀转动到自动质控包组件的输出端，通过吸液泵将质控液从自动质控包组件经分配阀吸至采样针，后通过采样针将质控液吐出至ISE分析系统接嘴，质控液吐经ISE分析系统接嘴输入至ISE分析系统进行自动质控。
作为本发明的进一步改进，通过反复进行步骤S1、S2以完成不同质控要求的自动测试。
作为本发明的进一步改进，在步骤S2中，所述ISE分析系统将测试得到的数据发送至后台。
 有益效果
本发明的有益效果是：通过上述方案，实现了电解质分析仪的自动质控，可以监控一段时期内仪器性能的好坏。
 附图说明
图1是本发明一种电解质分析仪的自动质控系统的示意图。
图2是本发明一种电解质分析仪的自动质控系统的局部示意图。
图3是本发明一种电解质分析仪的自动质控系统的局部示意图。
 本发明的实施方式
下面结合附图说明及具体实施方式对本发明作进一步说明。
如图1至图3所示，一种电解质分析仪的自动质控系统，包括自动质控包组件、清洗液包100、去脂水包114、可转动的分配阀104、吸液泵105、可转动升降的采样针106、进料接嘴、ISE分析系统，其中，所述进料接嘴包括废液装置接嘴107和ISE分析系统接嘴110，所述自动质控包组件、清洗液包100分别与所述分配阀104的输入端连接，所述分配阀104的输出端通过所述吸液泵105与所述采样针106的输入端连接，所述ISE分析系统接嘴110、废液装置接嘴107均位于所述采样针106的输出端的运动轨迹上，所述ISE分析系统接嘴110与所述ISE分析系统连接，所述废液装置接嘴107的输出端连接有清洗液废液装置108。
如图1至图3所示，所述自动质控包组件包括不同质控要求的第一自动质控包101、第二自动质控包102和第三自动质控包103，所述第一自动质控包101、第二自动质控包102、第三自动质控包103分别与所述分配阀104的输入端连接，第一自动质控包101装有高水平的质控液，第二自动质控包102装有中水平的质控液，第三自动质控包103装有低水平的质控液。
如图1至图3所示，所述分配阀104连接有旋转机构，所述采样针106连接有旋转升降机构，旋转机构可通过电机来实现，升降机构可通过气缸来实现。
如图1至图3所示，所述ISE分析系统包括流通池111和质控液吸液泵112，所述流通池111的输入端与所述ISE分析系统接嘴110连接，所述流通池111的输出端与所述质控液吸液泵112的输入端连接。
如图1至图3所示，所述质控液吸液泵112的输出端连接有质控液废液装置113。
如图1至图3所示，一种电解质分析仪的自动质控方法，以上述中任一项所述的电解质分析仪的自动质控系统为基础，进行以下步骤：
S1、清洗流路，将分配阀104转动到清洗液包100的输出端，通过吸液泵105将清洗液从清洗液包100经分配阀104吸至采样针106，然后通过采样针106将清洗液吐出至废液装置接嘴107，清洗液经废液装置接嘴107排出至废液装置108，以清洗流路；
S2、自动质控，将分配阀104转动到自动质控包组件的输出端，通过吸液泵105将质控液从自动质控包组件经分配阀104吸至采样针106，后通过采样针106将质控液吐出至ISE分析系统接嘴110，质控液吐经ISE分析系统接嘴110输入至ISE分析系统进行自动质控。
如图1至图3所示，通过反复进行步骤S1、S2以完成不同质控要求的自动测试。
如图1至图3所示，在步骤S2中，所述ISE分析系统将测试得到的数据发送至后台。
本发明提供的一种电解质分析仪的自动质控系统与方法，当仪器（电解质分析仪）需要做质控时，分配阀104先转动到清洗液包100对应的位置，然后清洗一下流路，然后分配阀104转动到第一自动质控包101，抽取质控液，采样针106转动到ISE分析系统接嘴110上方，将质控液吐到ISE分析系统接嘴110里，然后质控液吸液泵112将质控液抽到电解质分析仪的流通池111中，然后开始测试并获取测试数据，获取数据后，ISE分析系统自动进行流路清洗，准备下一个样本的测试，流通池111在获取数据的同时，进样系统回到初始位执行流路清洗，清洗完后，分配阀104转动到第二自动质控包102，执行同第一自动质控包101测试方法类似的操作。以此完成高中低三质控的自动测试。仪器根据测试的数据来分析一段时期仪器性能的好坏，并给出相应的预警和提示。
本发明提供的一种电解质分析仪的自动质控系统与方法，可以自动质控，可以监控仪器在一段时间中的性能好坏，能给出仪器预警以便医务人员获取准确的患者诊断数，有着极高的临床意义。
以上内容是结合具体的优选实施方式对本发明所作的进一步详细说明，不能认定本发明的具体实施只局限于这些说明。对于本发明所属技术领域的普通技术人员来说，在不脱离本发明构思的前提下，还可以做出若干简单推演或替换，都应当视为属于本发明的保护范围。

Claims (8)

  1. 一种电解质分析仪的自动质控系统，其特征在于：包括自动质控包组件、清洗液包、可转动的分配阀、吸液泵、可转动升降的采样针、进料接嘴、ISE分析系统，其中，所述进料接嘴包括废液装置接嘴和ISE分析系统接嘴，所述自动质控包组件、清洗液包分别与所述分配阀的输入端连接，所述分配阀的输出端通过所述吸液泵与所述采样针的输入端连接，所述ISE分析系统接嘴、废液装置接嘴均位于所述采样针的输出端的运动轨迹上，所述ISE分析系统接嘴与所述ISE分析系统连接，所述废液装置接嘴的输出端连接有清洗液废液装置。
  2. 根据权利要求1所述的电解质分析仪的自动质控系统，其特征在于：所述自动质控包组件包括不同质控要求的第一自动质控包、第二自动质控包和第三自动质控包，所述第一自动质控包、第二自动质控包、第三自动质控包分别与所述分配阀的输入端连接。
  3. 根据权利要求1所述的电解质分析仪的自动质控系统，其特征在于：所述分配阀连接有旋转机构，所述采样针连接有旋转升降机构。
  4. 根据权利要求1所述的电解质分析仪的自动质控系统，其特征在于：所述ISE分析系统包括流通池和质控液吸液泵，所述流通池的输入端与所述ISE分析系统接嘴连接，所述流通池的输出端与所述质控液吸液泵的输入端连接。
  5. 根据权利要求4所述的电解质分析仪的自动质控系统，其特征在于：所述质控液吸液泵的输出端连接有质控液废液装置。
  6. 一种电解质分析仪的自动质控方法，其特征在于，以权利要求1至5中任一项所述的电解质分析仪的自动质控系统为基础，进行以下步骤：
    S1、清洗流路，将分配阀转动到清洗液包的输出端，通过吸液泵将清洗液从清洗液包经分配阀吸至采样针，然后通过采样针将清洗液吐出至废液装置接嘴，清洗液经废液装置接嘴排出至废液装置，以清洗流路；
    S2、自动质控，将分配阀转动到自动质控包组件的输出端，通过吸液泵将质控液从自动质控包组件经分配阀吸至采样针，后通过采样针将质控液吐出至ISE分析系统接嘴，质控液吐经ISE分析系统接嘴输入至ISE分析系统进行自动质控。
  7. 根据权利要求6所述的电解质分析仪的自动质控方法，其特征在于：通过反复进行步骤S1、S2以完成不同质控要求的自动测试。
  8. 根据权利要求6所述的电解质分析仪的自动质控方法，其特征在于：在步骤S2中，所述ISE分析系统将测试得到的数据发送至后台。
     
PCT/CN2020/096454 2019-08-13 2020-06-17 一种电解质分析仪的自动质控系统与方法 WO2021027395A1 (zh)

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