WO2021027235A1 - 一种幼儿弱视脑电客观检测仪 - Google Patents

一种幼儿弱视脑电客观检测仪 Download PDF

Info

Publication number
WO2021027235A1
WO2021027235A1 PCT/CN2019/128994 CN2019128994W WO2021027235A1 WO 2021027235 A1 WO2021027235 A1 WO 2021027235A1 CN 2019128994 W CN2019128994 W CN 2019128994W WO 2021027235 A1 WO2021027235 A1 WO 2021027235A1
Authority
WO
WIPO (PCT)
Prior art keywords
eeg
module
amblyopia
virtual reality
electrocerebral
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/CN2019/128994
Other languages
English (en)
French (fr)
Inventor
徐光华
郑小伟
王云云
梁仍昊
刘洋
韩丞丞
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Xian Jiaotong University
Original Assignee
Xian Jiaotong University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Xian Jiaotong University filed Critical Xian Jiaotong University
Publication of WO2021027235A1 publication Critical patent/WO2021027235A1/zh
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
    • A61B3/10—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
    • A61B3/113—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions for determining or recording eye movement
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0002—Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network
    • A61B5/0004—Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network characterised by the type of physiological signal transmitted
    • A61B5/0006—ECG or EEG signals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • A61B5/316—Modalities, i.e. specific diagnostic methods
    • A61B5/369—Electroencephalography [EEG]
    • A61B5/377—Electroencephalography [EEG] using evoked responses
    • A61B5/378—Visual stimuli

Definitions

  • the invention relates to the technical field of brain-computer interface and amblyopia detection in ophthalmological examinations, in particular to an EEG objective detector for children with amblyopia.
  • amblyopia The developmental disorder of the visual nerve in young children leads to abnormalities in the visual system, leading to amblyopia.
  • the global incidence of amblyopia is as high as 3%-5%, and its main symptom is that the corrected best vision is lower than normal.
  • the factors that cause amblyopia include strabismus, refractive error, and form deprivation.
  • Monocular abnormality and inhibition between the two eyes are two mechanisms of amblyopia.
  • Monocular abnormality during development causes a decline in the ability of the amblyopic eye to compete for the visual path, and the visual function is mainly dominated by the contralateral eye.
  • Recent studies have shown that binocular suppression in amblyopia prevents normal fusion and perception of the eyes. Therefore, amblyopia is an abnormality in the development of the optic nerve, which is manifested in limited visual function.
  • the purpose of the present invention is to provide an EEG objective detector for children with amblyopia, which integrates visual evoked potential technology, virtual reality display technology, and eye tracker tracking technology. Starting from the cause, objective detection of amblyopia can be carried out. The operation is simple and fast, the applicability is strong, and the indicators are objective and quantitative.
  • An EEG objective detector for children with amblyopia including a virtual reality glasses module 1, an eye tracker module 2, a wireless EEG acquisition platform module 3, and a data analysis and management system module 4.
  • the virtual reality glasses module 1 realizes split-vision display of both eyes , Provides a means for the visual display of the stimulus pattern in the process of amblyopia detection; the eye tracker module 2 detects the eyeball direction of the child in the detection process in real time to ensure the effectiveness of the visual stimulation paradigm;
  • the wireless EEG acquisition platform module 3 integrates data transmission and The EEG signal amplification chip realizes the collection and transmission of EEG data; the data analysis and management system module 4 analyzes EEG data, and its detection results are displayed in real time and shared with doctors and patients.
  • the virtual reality glasses module 1 adopts the binocular split display technology of the virtual reality scene, so that the time frequency of the stimulation paradigm presented to the binocular is different, and the binocular difference is caused from the visual input, so as to facilitate the feature calibration in the EEG and further Analyze; at the same time, design a multi-color stimulation paradigm group.
  • Earphones 14 are provided on both sides of the virtual reality glasses module 1 to realize the input of auditory information.
  • the eye tracker module 2 is composed of a near-infrared light source 17 and two camera lenses 12.
  • the near-infrared light source 17 produces a reflection image on the cornea and pupil of the user's eye, and then uses two image sensors to collect the eye and the reflection Images, using image processing algorithms and a three-dimensional eyeball model to accurately calculate the position of the eye in space and the position of the line of sight, tracking the eyeball position, and ensuring the effectiveness of stimulation.
  • the near-infrared light source 17 and the two camera lenses 12 are respectively inserted into the near-infrared light source fixing groove 8 and the camera lens fixing groove 7 for fixing the virtual reality glasses module 1, so that the eye tracker module 2 and the virtual reality The reality glasses module 1 is integrated as a whole.
  • the wireless EEG acquisition platform module 3 is composed of a wireless EEG helmet 19, an EEG signal amplifier 20, an EEG signal transmitter 18, a forehead electrode 15, a ground electrode 13, and an occipital lobe visual area EEG electrode 10;
  • the EEG helmet cap 19 is connected to the virtual reality glasses module 1 through the connecting headband 9, which is adjustable in expansion and contraction, and the wireless EEG helmet cap 19 integrates six occipital lobe visual area EEG electrodes 10, occipital lobe visual area EEG
  • the electrode 10 combines the forehead electrode 15 and the ground electrode 13 as a reference to collect EEG signals in real time.
  • the EEG signal amplifier 20 is used for initial signal amplification, and then the EEG signal transmitter 18 transmits the EEG signals for data analysis and management.
  • System module 4 is used for initial signal amplification, and then the EEG signal transmitter 18 transmits the EEG signals for data analysis and management.
  • the size of the wireless EEG helmet 19 is designed according to the standard size of a 5-year-old child.
  • the data analysis and management system module 4 is composed of an EEG signal receiver 5 and a data analysis and management system 6.
  • the EEG signal receiver 5 communicates with the EEG signal transmitter 18 to receive EEG signals therefrom; data
  • the analysis and management system 6 preprocesses the signal, extracts features, and classifies the signal to obtain objective detection results for amblyopia; then conducts unified classification management of patient information, EEG data, detection parameters, and amblyopia results, patient information and amblyopia results Share with patients.
  • the present invention has the following beneficial effects:
  • the present invention applies brain-computer interface technology, integrates virtual reality split-vision display technology, eye tracker tracking technology and database management technology, and can realize fast and non-destructive young children’s amblyopia EEG objective in a short time Quantitative testing provides a new method for early screening of children with amblyopia.
  • Figure 1 is a schematic diagram of the structure of the present invention.
  • Fig. 2 is an exploded view of the eye tracker module, virtual reality glasses module and wireless EEG acquisition platform module of the present invention.
  • Fig. 3 is a schematic diagram of the binocular split display technology of a virtual reality scene.
  • Figure 4 is a schematic diagram of a multi-color visual stimulation paradigm group.
  • Figure 5 is a rear side view of the wireless EEG acquisition platform module.
  • an EEG objective detector for children with amblyopia includes a virtual reality glasses module 1, an eye tracker module 2, a wireless EEG acquisition platform module 3, a data analysis and management system module 4, and a virtual reality glasses module 1.
  • a virtual reality glasses module 1 Realize the split display of both eyes, which provides a means for the split display of stimulus patterns in the process of amblyopia detection; for the children's hyperactive and inattentive characteristics, the eye tracker module 2 detects the eyeball direction of the children in real time during the detection process to ensure The effectiveness of the visual stimulation paradigm;
  • the wireless EEG acquisition platform module 3 is easy to operate, integrates data transmission and EEG signal acquisition functions to realize EEG data collection and transmission;
  • Data analysis and management system module 4 performs EEG data analysis, Its detection is displayed in real time and shared with doctors and patients.
  • the virtual reality glasses module 1 starts from the root cause that amblyopia occurs in one eye and the development of the two eyes is not coordinated, and uses the binocular split display technology of the virtual reality scene to make the stimulus paradigm presented in both eyes 16
  • the time frequency is different, and the visual input is caused by the difference between the eyes, which is convenient for feature calibration and analysis in the EEG;
  • a multi-color stimulation paradigm set is designed for easy use Visual stimuli induce EEG signals;
  • the earphones 14 located on both sides of the virtual reality glasses module 1 realize the input of auditory information, making the detection process more immersive and fun;
  • the master switch 11 is located in the virtual reality glasses module 1Right side.
  • the eye tracker module 2 is composed of a near-infrared light source 17 and two camera lenses 12.
  • the near-infrared light source 17 and the two camera lenses 12 are respectively inserted into the virtual reality glasses module 1 for
  • the near-infrared light source fixing groove 8 and the camera lens fixing groove 7 are fixed, so that the eye tracker module 2 and the virtual reality glasses module 1 are integrated as a whole, which is convenient for operation;
  • the near-infrared light source 17 makes the cornea and pupil of the user's eye
  • the reflected image is produced, and two camera lenses 12 are used to collect the images of the eyes and the reflection;
  • the image processing algorithm and a three-dimensional eyeball model are used to accurately calculate the position of the eye in space and the position of the line of sight, and track the eyeball position to ensure effective stimulation Sex.
  • the wireless EEG acquisition platform module 3 consists of a wireless EEG helmet cap 19, an EEG signal amplifier 20, an EEG signal transmitter 18, a forehead electrode 15, a ground electrode 13, and a pillow
  • the size of the wireless EEG helmet cap 19 is designed according to the standard size of 5-year-old children. It is connected to the virtual reality glasses module 1 through the connection headband 9, which can be stretched and adjusted, and can fit differently.
  • the wireless EEG helmet cap 19 can not only play a fixed role, but also integrates six occipital visual area EEG electrodes 10 (POz, PO3, Po4, Oz, O1 and O2), the EEG electrode 10 in the occipital visual area combines the forehead electrode 15 (Fpz) and the ground electrode 13 (A1, A2) as a reference to collect the EEG signal in real time, and perform the initial amplification of the signal through the EEG signal amplifier 20 After processing, the EEG signal transmitter 18 transmits the EEG signal to the data analysis and management system module 4.
  • EEG electrodes 10 POz, PO3, Po4, Oz, O1 and O2
  • the data analysis and management system module 4 is composed of an EEG signal receiver 5 and a data analysis and management system 6.
  • the EEG signal receiver 5 communicates with the EEG signal transmitter 18 and receives
  • the data analysis and management system 6 preprocesses the signals, extracts features, and classifies the signals to obtain objective detection results of amblyopia; then conducts unified classification management on patient information, EEG data, detection parameters, and amblyopia results , Patient information and amblyopia results are shared with patients.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Physiology (AREA)
  • Computer Networks & Wireless Communication (AREA)
  • Human Computer Interaction (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
  • Position Input By Displaying (AREA)
  • Eye Examination Apparatus (AREA)

Abstract

一种幼儿弱视脑电客观检测仪，包括虚拟现实眼镜模块(1)、眼动仪模块(2)、无线脑电采集平台模块(3)和数据分析与管理系统模块(4)，虚拟现实眼镜模块(1)实现双眼的分视显示，为弱视检测过程中的刺激图案分视显示提供了手段；眼动仪模块(2)实时检测幼儿检测过程中的眼球方向，保证视觉刺激范式(16)的有效性；无线脑电采集平台模块(3)集成数据传输与脑电信号放大芯片，实现脑电数据的采集与传输；数据分析与管理系统模块(4)进行脑电数据的分析，其检测结果实时显示并与医生和患者共享；集成视觉诱发电位技术、虚拟现实显示技术、眼动仪追踪技术于一体，从弱视形成的根本原因出发，可进行弱视的客观检测。操作简单快捷，适用性强，且指标客观定量。

Description

一种幼儿弱视脑电客观检测仪 技术领域
本发明涉及脑机接口及眼科检查中弱视检测技术领域，具体涉及一种幼儿弱视脑电客观检测仪。
背景技术
幼儿视觉神经发育失调导致视觉系统异常，进而形成弱视。全球弱视的发病率高达3％-5％，其主要症状表现为矫正后的最佳视力低于正常值。造成弱视的因素有斜视、屈光不正和形觉剥夺等。单眼异常和双眼间的抑制是弱视形成的两种机制。在发育期间的单眼异常造成弱视眼竞争视路的能力下降，视觉功能主要由对侧眼支配。而近年来的研究表明弱视间的双眼抑制阻止了眼睛的正常融合和感知。因此，弱视是视觉神经发育出现异常，表现在视觉功能受限。
现有的弱视检测方法，包括从视力、立体视、融合视等方面进行主观心理物理学检测，不能从根本出发直接进行检测，错失了弱视修复治疗的关键期。脑机接口技术，特别是皮层脑电技术，不依赖于人的主观判断，可直接从弱视形成的根本原因出发，采集视觉区脑电，应用视觉诱发电位技术，实现弱视的客观检测。
发明内容
为了克服上述现有技术的缺点，本发明的目的在于提供了一种幼儿弱视脑电客观检测仪，集成视觉诱发电位技术、虚拟现实显示技术、眼动仪追踪技术于一体，从弱视形成的根本原因出发，可进行弱视的客观检测。操作简单快捷，适用性强，且指标客观定量。
为了达到上述目的，本发明采用的技术方案是：
一种幼儿弱视脑电客观检测仪，包括虚拟现实眼镜模块1、眼动仪模块2、无线脑电采集平台模块3和数据分析与管理系统模块4，虚拟现实眼镜模块1实现双眼的分视显示，为弱视检测过程中的刺激图案分视显示提供了手段；眼动仪模块2实时检测幼儿检测过程中的眼球方向，保证视觉刺激范式的有效性；无线脑电采集平台模块3集成数据传输与脑电信号放大芯片，实现脑电数据的采集与传输；数据分析与管理系统模块4进行脑电数据的分析，其检测结果实时显示与并与医生和患者共享。
所述的虚拟现实眼镜模块1采用虚拟现实场景的双眼分视显示技术，使得呈现于双眼的刺激范式的时间频率不同，从视觉输入上造成双眼差异，以便于在脑电中进行特征标定与进一步分析；同时，设计多种颜色的刺激范式组。
所述的虚拟现实眼镜模块1两侧设有耳机14，实现听觉信息的输入。
所述的眼动仪模块2由一个近红外光源17与两个摄像镜头12组成，近红外光源17使用户眼睛的角膜和瞳孔上产成反射图像，然后使用两个图像传感器采集眼睛与反射的图像，使用图像处理算法和一个三维眼球模型精确地计算出眼睛在空间中的位置和视线位置，跟踪眼球位置，保证刺激的有效性。
所述的近红外光源17、两个摄像镜头12分别插入虚拟现实眼镜模块1中用于固定其的近红外光源固定凹槽8、摄像镜头固定凹槽7内，使得眼动仪模块2与虚拟现实眼镜模块1结合为一个整体。
所述的无线脑电采集平台模块3由无线脑电头盔帽19、脑电信号放大器20、脑电信号发射器18、前额电极15、接地电极13、枕叶视觉区脑电电极10组成；无线脑电头盔帽19与虚拟现实眼镜模块1通过连接头带9相连，连接头带9伸 缩可调，无线脑电头盔帽19集成六个枕叶视觉区脑电电极10,枕叶视觉区脑电电极10结合作为参考的前额电极15与接地电极13，实时采集脑电信号，通过脑电信号放大器20进行信号的初始放大处理，再由脑电信号发射器18传输脑电信号于数据分析与管理系统模块4。
所述的无线脑电头盔帽19尺寸根据5岁幼儿标准尺寸设计。
所述的数据分析与管理系统模块4由脑电信号接收器5、数据分析与管理系统6组成；脑电信号接收器5与脑电信号发射器18通讯，接收来自其的脑电信号；数据分析与管理系统6对信号进行预处理、特征提取并进行分类，得出弱视客观检测结果；再对患者信息、脑电数据、检测参数和弱视结果等信息进行统一分类管理，患者信息和弱视结果与患者共享。
与背景技术相比，本发明具有的有益效果是：
本发明从弱视形成的根本原因出发，应用脑机接口技术，集成虚拟现实分视显示技术、眼动仪追踪技术及数据库管理技术，可在短时间内实现了快速、无损地幼儿弱视脑电客观量化检测，为幼儿弱视早期筛查提供全新的手段。
附图说明
图1为本发明的结构示意图。
图2为本发明眼动仪模块、虚拟现实眼镜模块和无线脑电采集平台模块的分解图。
图3为虚拟现实场景的双眼分视显示技术的示意图。
图4为多种颜色视觉刺激范式组示意图。
图5为无线脑电采集平台模块的后侧视图。
具体实施方式
下面结合附图对本发明做详细描述。
如图1所示，一种幼儿弱视脑电客观检测仪，包括虚拟现实眼镜模块1、眼动仪模块2、无线脑电采集平台模块3和数据分析与管理系统模块4，虚拟现实眼镜模块1实现双眼的分视显示，为弱视检测过程中的刺激图案分视显示提供了手段；针对幼儿多动且注意力不集中的特点，眼动仪模块2实时检测幼儿检测过程中的眼球方向，保证视觉刺激范式的有效性；无线脑电采集平台模块3方便操作，集成数据传输与脑电信号采集功能，实现脑电数据的采集与传输；数据分析与管理系统模块4进行脑电数据的分析，其检测实时显示与并与医生和患者共享。
如图2、3所示，所述的虚拟现实眼镜模块1从弱视多发于单眼且双眼发育不协调的根本原因出发，采用虚拟现实场景的双眼分视显示技术，使得呈现于双眼的刺激范式16的时间频率不同，从视觉输入上造成双眼差异，以便于在脑电中进行特征标定与分析；如图4所示，为了吸引幼儿的注意力，设计多种颜色的刺激范式组,以便于利用视觉刺激诱发脑电信号；如图2所示，位于虚拟现实眼镜模块1两侧的耳机14，实现听觉信息的输入，使检测过程更具有沉浸性和乐趣性；总开关11位于虚拟现实眼镜模块1右侧。
如图2、3所示，所述的眼动仪模块2由一个近红外光源17与两个摄像镜头12组成，近红外光源17、两个摄像镜头12分别插入虚拟现实眼镜模块1中用于固定其的近红外光源固定凹槽8、摄像镜头固定凹槽7内，使得眼动仪模块2与虚拟现实眼镜模块1结合为一个整体，便于操作；近红外光源17使用户眼睛的角膜和瞳孔上产成反射图像，使用两个摄像镜头12采集眼睛与反射的图像；使用图像处理算法和一个三维眼球模型精确地计算出眼睛在空间中的位置和视线位置，跟踪眼球位置，保证刺激的有效性。
如图2、3、5所示，所述的无线脑电采集平台模块3由无线脑电头盔帽19、脑电信号放大器20、脑电信号发射器18、前额电极15、接地电极13、枕叶视觉区脑电电极10组成；无线脑电头盔帽19尺寸根据5岁幼儿标准尺寸设计，其与虚拟现实眼镜模块1通过连接头带9相连，连接头带9伸缩可调，能够贴合不同大小的头型，满足了个体头部尺寸的差异性；无线脑电头盔帽19既可以起到固定的作用，又集成六个枕叶视觉区脑电电极10(POz、PO3、Po4、Oz、O1和O2),枕叶视觉区脑电电极10结合作为参考的前额电极15(Fpz)与接地电极13(A1，A2)，实时采集脑电信号，通过脑电信号放大器20进行信号的初始放大处理，再由脑电信号发射器18传输脑电信号于数据分析与管理系统模块4。
如图1所示，所述的数据分析与管理系统模块4由脑电信号接收器5、数据分析与管理系统6组成；脑电信号接收器5与脑电信号发射器18通讯，接收来自其的脑电信号；数据分析与管理系统6对信号进行预处理、特征提取并进行分类，得出弱视客观检测结果；再对患者信息、脑电数据、检测参数和弱视结果等信息进行统一分类管理，患者信息和弱视结果与患者共享。

Claims (8)

  1. 一种幼儿弱视脑电客观检测仪，其特征在于：包括虚拟现实眼镜模块(1)、眼动仪模块(2)、无线脑电采集平台模块(3)和数据分析与管理系统模块(4)，虚拟现实眼镜模块(1)实现双眼的分视显示，为弱视检测过程中的刺激图案分视显示提供了手段；眼动仪模块(2)实时检测幼儿检测过程中的眼球方向，保证视觉刺激范式的有效性；无线脑电采集平台模块(3)集成数据传输与脑电信号放大芯片，实现脑电数据的采集与传输；数据分析与管理系统模块(4)进行脑电数据的分析，其检测结果实时显示与并与医生和患者共享。
  2. 根据权利要求1所述的一种幼儿弱视脑电客观检测仪，其特征在于：所述的虚拟现实眼镜模块(1)采用虚拟现实场景的双眼分视显示技术，使得呈现于双眼的刺激范式的时间频率不同，从视觉输入上造成双眼差异，以便于在脑电中进行特征标定与进一步分析；同时，设计多种颜色的刺激范式组。
  3. 根据权利要求1所述的一种幼儿弱视脑电客观检测仪，其特征在于：所述的虚拟现实眼镜模块(1)两侧设有耳机(14)，实现听觉信息的输入。
  4. 根据权利要求1所述的一种幼儿弱视脑电客观检测仪，其特征在于：所述的眼动仪模块(2)由一个近红外光源(17)与两个摄像镜头(12)组成，近红外光源(17)使用户眼睛的角膜和瞳孔上产成反射图像，然后使用两个图像传感器采集眼睛与反射的图像，使用图像处理算法和一个三维眼球模型精确地计算出眼睛在空间中的位置和视线位置，跟踪眼球位置，保证刺激的有效性。
  5. 根据权利要求4所述的一种幼儿弱视脑电客观检测仪，其特征在于：所述的近红外光源(17)、两个摄像镜头(12)分别插入虚拟现实眼镜模块(1)中的近红外光源固定凹槽(8)、摄像镜头固定凹槽(7)内，使得眼动仪模块(2) 与虚拟现实眼镜模块(1)结合为一个整体。
  6. 根据权利要求1所述的一种幼儿弱视脑电客观检测仪，其特征在于：所述的无线脑电采集平台模块(3)由无线脑电头盔帽(19)、脑电信号放大器(20)、脑电信号发射器(18)、前额电极(15)、接地电极(13)、枕叶视觉区脑电电极(10)组成；无线脑电头盔帽(19)与虚拟现实眼镜模块(1)通过连接头带(9)相连，连接头带(9)伸缩可调，无线脑电头盔帽(19)集成六个枕叶视觉区脑电电极(10),枕叶视觉区脑电电极(10)结合作为参考的前额电极(15)与接地电极(13)，实时采集脑电信号，通过脑电信号放大器(20)进行信号的初始放大处理，再由脑电信号发射器(18)传输脑电信号于数据分析与管理系统模块(4)。
  7. 根据权利要求6所述的一种幼儿弱视脑电客观检测仪，其特征在于：所述的无线脑电头盔帽(19)尺寸根据5岁幼儿标准尺寸设计。
  8. 根据权利要求1所述的一种幼儿弱视脑电客观检测仪，其特征在于：所述的数据分析与管理系统模块(4)由脑电信号接收器(5)、数据分析与管理系统(6)组成；脑电信号接收器(5)与脑电信号发射器(18)通讯，接收来自其的脑电信号；数据分析与管理系统(6)对信号进行预处理、特征提取并进行分类，得出弱视客观检测结果；再对患者信息、脑电数据、检测参数和弱视结果信息进行统一分类管理，患者信息和弱视结果与患者共享。
PCT/CN2019/128994 2019-08-09 2019-12-27 一种幼儿弱视脑电客观检测仪 Ceased WO2021027235A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201910734032.7 2019-08-09
CN201910734032.7A CN110547760A (zh) 2019-08-09 2019-08-09 一种幼儿弱视脑电客观检测仪

Publications (1)

Publication Number Publication Date
WO2021027235A1 true WO2021027235A1 (zh) 2021-02-18

Family

ID=68737336

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CN2019/128994 Ceased WO2021027235A1 (zh) 2019-08-09 2019-12-27 一种幼儿弱视脑电客观检测仪

Country Status (2)

Country Link
CN (1) CN110547760A (zh)
WO (1) WO2021027235A1 (zh)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110547760A (zh) * 2019-08-09 2019-12-10 西安交通大学 一种幼儿弱视脑电客观检测仪
CN111820865B (zh) * 2020-07-24 2024-05-17 安徽猫头鹰科技有限公司 一种眼部视觉数据采集在线监控系统
CN111920411A (zh) * 2020-09-08 2020-11-13 司法鉴定科学研究院 视力客观评定和/或视觉诱发电位的检测方法及系统
CN112842261B (zh) * 2020-12-30 2021-12-28 西安交通大学 一种基于复杂网络的婴儿三维自发运动智能化评估系统
CN113576497B (zh) * 2021-08-30 2023-09-08 清华大学深圳国际研究生院 一种面向双眼竞争的视觉稳态诱发电位检测系统
CN114190879B (zh) * 2021-12-17 2025-08-08 开封大学 基于虚拟现实技术的弱视儿童视功能检测系统
CN116407084A (zh) * 2021-12-29 2023-07-11 中国科学院深圳先进技术研究院 一种多维度信号控制系统和方法
CN116098638A (zh) * 2023-03-31 2023-05-12 杭州电子科技大学 一种具有电极自贴合功能的脑电采集眼镜装置
CN116687337A (zh) * 2023-07-05 2023-09-05 杭州集视智能科技有限公司 基于扩展现实技术客观量化人群双眼间抑制程度的方法

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012044261A1 (en) * 2010-09-29 2012-04-05 The Office Of National Telecommunications Commission System and method for ssvep based control of electrical devices
CN106037627A (zh) * 2016-05-20 2016-10-26 上海青研科技有限公司 一种婴幼儿全自动视力检查方法及装置
CN107463249A (zh) * 2017-06-29 2017-12-12 南京航空航天大学 基于vr头显视觉诱发电位的脑机接口系统及控制方法
CN109222970A (zh) * 2018-07-09 2019-01-18 司法鉴定科学研究院 视力客观评定的设备及视觉诱发电位的检测系统与方法
CN109271020A (zh) * 2018-08-23 2019-01-25 西安交通大学 一种基于眼动追踪的稳态视觉诱发脑机接口性能评价方法
CN109645955A (zh) * 2019-01-31 2019-04-19 北京大学第三医院（北京大学第三临床医学院） 基于vr和眼动追踪的多功能视觉功能检测装置及方法
CN109717828A (zh) * 2018-10-24 2019-05-07 中国医学科学院生物医学工程研究所 一种视野检查设备及检测方法
CN110547760A (zh) * 2019-08-09 2019-12-10 西安交通大学 一种幼儿弱视脑电客观检测仪

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7578795B2 (en) * 2001-08-07 2009-08-25 Diopsys, Inc. System and method for vision examination utilizing fault detection
CN1903150A (zh) * 2006-05-10 2007-01-31 上海迪康医学生物技术有限公司 一种通过空间频率阈值变化治疗儿童弱视的方法
CN100466964C (zh) * 2007-03-20 2009-03-11 重庆大学 一种用于分离双眼视觉诱发电位的系统
CN105138818B (zh) * 2015-07-23 2019-02-05 西安交通大学 结合图形视觉诱发电位的弱视辅助诊疗系统
CN205866721U (zh) * 2016-05-20 2017-01-11 上海青研科技有限公司 一种婴幼儿全自动视力检查装置
US20180132751A1 (en) * 2016-11-14 2018-05-17 Medisim, Ltd. Automatic system and method for evaluating and treating visual health
CN106774847A (zh) * 2016-11-24 2017-05-31 天津大学 基于虚拟现实技术的三维视觉P300‑Speller系统
CN106919256A (zh) * 2017-02-27 2017-07-04 深圳市金立通信设备有限公司 一种保护终端用户眼部健康的方法及终端
CN108133189B (zh) * 2017-12-22 2020-05-01 苏州大学 医院候诊信息显示方法

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012044261A1 (en) * 2010-09-29 2012-04-05 The Office Of National Telecommunications Commission System and method for ssvep based control of electrical devices
CN106037627A (zh) * 2016-05-20 2016-10-26 上海青研科技有限公司 一种婴幼儿全自动视力检查方法及装置
CN107463249A (zh) * 2017-06-29 2017-12-12 南京航空航天大学 基于vr头显视觉诱发电位的脑机接口系统及控制方法
CN109222970A (zh) * 2018-07-09 2019-01-18 司法鉴定科学研究院 视力客观评定的设备及视觉诱发电位的检测系统与方法
CN109271020A (zh) * 2018-08-23 2019-01-25 西安交通大学 一种基于眼动追踪的稳态视觉诱发脑机接口性能评价方法
CN109717828A (zh) * 2018-10-24 2019-05-07 中国医学科学院生物医学工程研究所 一种视野检查设备及检测方法
CN109645955A (zh) * 2019-01-31 2019-04-19 北京大学第三医院（北京大学第三临床医学院） 基于vr和眼动追踪的多功能视觉功能检测装置及方法
CN110547760A (zh) * 2019-08-09 2019-12-10 西安交通大学 一种幼儿弱视脑电客观检测仪

Also Published As

Publication number Publication date
CN110547760A (zh) 2019-12-10

Similar Documents

Publication Publication Date Title
WO2021027235A1 (zh) 一种幼儿弱视脑电客观检测仪
KR102564748B1 (ko) 건강 질환 진단과 치료를 위한 방법 및 시스템
CN106037627B (zh) 一种婴幼儿全自动视力检查方法及装置
EP2467053B1 (en) Apparatus and method for automatically determining a strabismus angle
US9380938B2 (en) System and methods for documenting and recording of the pupillary red reflex test and corneal light reflex screening of the eye in infants and young children
US20180249941A1 (en) Oculometric Neurological Examination (ONE) Appliance
RU2634682C1 (ru) Портативное устройство для исследования зрительных функций
CN110236482A (zh) 一体化眼脑部视觉功能成像系统
CN113080836B (zh) 非中心注视的视觉检测与视觉训练设备
CN101474061B (zh) 一种接触式眼底成像系统
Haslwanter et al. Eye movement measurement: electro-oculography and video-oculography
CN205866721U (zh) 一种婴幼儿全自动视力检查装置
CN211704590U (zh) 一体化眼脑部视觉功能成像系统
WO2019052246A1 (zh) 一种便携式视觉电生理检测系统
CN117257227A (zh) 动态瞬时视力测量及波前像差连续探测联合瞬目特征分析三通道实时整合系统
US12257061B2 (en) Device for exploring the visual system
CN211511766U (zh) 一种甩头抑制试验眼罩
CN211460224U (zh) 一种实时采集眼球运动及头部运动的眼罩
CN115399729A (zh) 一种在体细胞水平的视功能检测设备及方法
Yagi Nystagmus as a sign of labyrinthine disorders-three-dimensional analysis of nystagmus
Boleas-Aguirre et al. Vestibulo-oculomotor reflex recording using the scleral search coil technique. Review of peripheral vestibular disorders
CN208659362U (zh) 一种便携式视觉电生理检测系统
CN210842988U (zh) 一种眼底图像立体检查光学系统
KR20070113539A (ko) 근적외선을 이용한 세극등 검사장치
Das et al. and Teleophthalmology

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 19940977

Country of ref document: EP

Kind code of ref document: A1

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 19940977

Country of ref document: EP

Kind code of ref document: A1

32PN Ep: public notification in the ep bulletin as address of the adressee cannot be established

Free format text: NOTING OF LOSS OF RIGHTS PURSUANT TO RULE 112(1) EPC (EPO FORM 1205A DATED 22/05/2023)

122 Ep: pct application non-entry in european phase

Ref document number: 19940977

Country of ref document: EP

Kind code of ref document: A1