WO2021023673A1 - Procédé de prévention et/ou de traitement de la transpiration et composition associée - Google Patents

Procédé de prévention et/ou de traitement de la transpiration et composition associée Download PDF

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Publication number
WO2021023673A1
WO2021023673A1 PCT/EP2020/071731 EP2020071731W WO2021023673A1 WO 2021023673 A1 WO2021023673 A1 WO 2021023673A1 EP 2020071731 W EP2020071731 W EP 2020071731W WO 2021023673 A1 WO2021023673 A1 WO 2021023673A1
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WIPO (PCT)
Prior art keywords
composition
process according
alkali metal
weight
chosen
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PCT/EP2020/071731
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English (en)
Inventor
Abel Messavussu
Francis Pruche
Gwenaelle Jegou
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L'oreal
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Publication of WO2021023673A1 publication Critical patent/WO2021023673A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/25—Silicon; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
    • A61K8/4946—Imidazoles or their condensed derivatives, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/55—Phosphorus compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q15/00—Anti-perspirants or body deodorants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
    • A61K2800/88—Two- or multipart kits
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
    • A61K2800/88—Two- or multipart kits
    • A61K2800/882—Mixing prior to application
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
    • A61K2800/88—Two- or multipart kits
    • A61K2800/884—Sequential application

Definitions

  • the present invention relates to a cosmetic process for preventing and/or treating perspiration.
  • the present invention also relates to a cosmetic composition, in particular for preventing and/or treating perspiration.
  • the underarms as well as certain other parts of the body are generally the place of several discomforts that can stem directly or not from perspiration problems. These phenomena often cause unpleasant and uncomfortable sensations which are primarily due to the presence of sweat resulting from perspiration. In certain cases, perspiration makes the skin moist and wets clothing, in particular at the level of the underarms or the back, as such leaving visible traces. Moreover, the presence of sweat can generate the discharging of body odors that are most of the time unpleasant. Finally, during the evaporation thereof, sweat can also leave behind salts and/or proteins on the surface of the skin which can cause white traces on clothing. Such discomforts are to be taken into account including in the case of moderate perspiration.
  • antiperspirant products containing substances that have for effect to limit and even suppress the sweat flow so as to remedy the problems mentioned hereinabove.
  • These products are in general available in the form of roll-on, sticks, aerosol or spray.
  • the antiperspirant substances are in general comprised of aluminum and/or zirconium hydrochlorides. These substances make it possible to reduce the sweat flow by forming a plug on the sweat channel.
  • compositions for preventing and/or treating perspiration that do not have all of the disadvantages described hereinabove, i.e. that do not involve the use of aluminum and or zirconium hydrochlorides, while still conferring a satisfactory antiperspirant effect.
  • the inventors have now discovered that the use, on a keratin material, of the association of an alkali metal metasilicate with at least one specific chelating compound chosen from phosphonic derivatives and amino acids, makes it possible to reduce the sweat flow.
  • the present invention has for object a cosmetic process for preventing and/or treating perspiration, that comprises the putting into contact of a keratin material, preferably the skin, with a composition comprising, in a cosmetically acceptable medium, at least one alkali metal metasilicate and at least one chelating compound chosen from phosphonic derivatives having the following formula (I):
  • R represents a linear or branched, cyclic or non-cyclic, saturated or unsaturated, alkyl radical, comprising from 1 to 10 carbon atoms, and n represents a whole number comprised between 1 and 10, and amino acids, said composition having a pH greater than or equal to 2 and less than 8.
  • the present invention also has for object a cosmetic composition, in particular for preventing and/or treating perspiration, that comprises, in a cosmetically acceptable medium, at least one alkali metal metasilicate and at least one chelating compound chosen from phosphonic derivatives having the following formula (I):
  • R represents a linear or branched, cyclic or non-cyclic, saturated or unsaturated, alkyl radical, comprising from 1 to 10 carbon atoms, and n represents a whole number comprised between 1 and 10, and amino acids, said composition further having a pH greater than or equal to 2 and less than 8.
  • compositions according to the invention are both indifferently called “compositions according to the invention”.
  • cosmetically acceptable medium means a medium compatible with the skin and/or integuments or mucosa thereof, having a pleasant color, odor and texture and not giving rise to unacceptable discomfort (such as tightness), liable to dissuade the consumer from using the composition.
  • Said cosmetically acceptable medium is also a medium that does not leave any traces during the application thereof, and that does not as such stain clothing.
  • Said cosmetically acceptable medium preferably comprises an aqueous phase.
  • the composition according to the invention has a pH greater than or equal to 2 and less than 8.
  • the pH is less than 4.
  • the pH is strictly less than 4.
  • the pH is less than 3.9, preferably less than 3.8.
  • the pH is greater than or equal to 2.1 , preferably greater than or equal to 2.2.
  • the pH is comprised between 2.1 and 4.
  • the pH is greater than or equal to 2.1 and strictly less than 4.
  • the pH is comprised between 2.5 and 3.4.
  • the composition according to the invention is a colloidal composition comprising silicic acid in amorphous form.
  • the composition according to the invention comprises at least one alkali metal metasilicate and at least two different chelating compounds chosen from phosphonic derivatives of formula (I) and amino acids.
  • the composition according to the invention comprises at least one alkali metal metasilicate and at least three different chelating compounds chosen from phosphonic derivatives of formula (I) and amino acids.
  • the composition according to the invention is obtained by the mixture of a composition B1 comprising an alkali metal metasilicate with a composition B2 comprising at least one chelating compound, the pH of said composition B1 being greater than or equal to 13 and the pH of said composition B2 being less than 2.
  • the method according to the invention comprises: a) the mixture of a composition B1 comprising an alkali metal metasilicate with a composition B2 comprising at least one chelating compound, the pH of said composition B1 being greater than or equal to 13 and the pH of said composition B2 being less than 2, in order to obtain a composition, then b) the putting into contact of a keratin material, preferably the skin, with the composition obtained in a).
  • the mixture of the composition B1 with the composition B2 is carried out extemporaneously, preferably for a duration comprised between 0.1 second and 1 hour, preferably between 0.1 second and 45 minutes, preferably between 1 second and 10 minutes.
  • the term "extemporaneously" means that the mixture of the composition B1 with the composition B2 is carried out before the putting into contact with the keratin material.
  • the mixture of the composition B1 with the composition B2 is carried out for a duration comprised between 0.1 second and 1 hour, preferably between 0.1 second and 45 minutes, preferably between 1 second and 10 minutes, before the putting into contact with the keratin material.
  • the mixture of the composition B1 with the composition B2 is carried out by simultaneously applying on the keratin material said compositions B1 and B2.
  • the mixture of the composition B1 with the composition B2 is carried out by sequentially applying on the keratin material said compositions B1 and B2.
  • the composition B2 is applied before the composition B1 .
  • the mixture of the composition B1 with the composition B2 is carried out extemporaneously.
  • the cosmetic process according to the invention comprises the putting into contact of a keratin material, preferably the skin, with a composition comprising, in a cosmetically acceptable medium, at least one alkali metal metasilicate.
  • a composition comprising, in a cosmetically acceptable medium, at least one alkali metal metasilicate.
  • the composition according to the invention comprises at least one alkali metal metasilicate.
  • alkali metal metasilicate means an anhydrous compound of formula M 2 S1O 3 , but also the hydrated forms of general formula M 2 Si0 3 .nH 2 0, M being an alkali metal.
  • n varies from 1 to 10.
  • the alkali metal M is chosen from lithium (Li), sodium (Na) and potassium (K).
  • M represents sodium (Na).
  • the alkali metal metasilicate is disodium metasilicate, preferably the anhydrous compound Na 2 SiC> 3 .
  • the disodium metasilicate is different from sodium orthosilicate and sodium disilicate.
  • sodium orthosilicate is the compound of formula Na 4 Si0 4
  • sodium disilicate is the compound IS ⁇ ShOs.
  • the concentration in alkali metal metasilicate in the composition B1 varies between 0.1 % and 15% by weight, preferably between 0.5% and 12% by weight, preferably between 1% and 11% by weight, in relation to the total weight of the composition B1 .
  • the cosmetic process according to the invention comprises the putting into contact of a keratin material, preferably the skin, with a composition comprising, in a cosmetically acceptable medium, at least one chelating compound chosen from phosphonic derivatives having the following formula (I):
  • R represents a linear or branched, cyclic or non-cyclic, saturated or unsaturated, alkyl radical, comprising from 1 to 10 carbon atoms, and n represents a whole number comprised between 1 and 10, and amino acids.
  • composition according to the invention comprises at least one chelating compound.
  • the chelating compound can be chosen from phosphonic derivatives having the following formula (I):
  • R represents a linear or branched, cyclic or non-cyclic, saturated or unsaturated, alkyl radical, comprising from 1 to 10 carbon atoms, and n represents a whole number comprised between 1 and 10.
  • alkyl radical means a linear or branched, cyclic or non-cyclic, saturated or unsaturated hydrocarbon group, comprising from 1 to 10 carbon atoms, preferably from 4 to 8 carbon atoms, preferably from 5 to 7 carbon atoms. Preferably, the alkyl radical is not substituted.
  • the alkyl radical is linear cyclic saturated.
  • the alkyl radical is the cyclohexyl radical.
  • n is a whole number comprised between 4 and 8, preferably comprised between 5 and 7.
  • n 6.
  • the phosphonic derivatives of formula (I) are such that R represents a linear cyclic saturated alkyl radical, comprising from 1 to 10 carbon atoms, preferably from 4 to 8 carbon atoms, preferably between 5 and 7 carbon atoms, and n represents a whole number comprised between 1 and 10, preferably comprised between 4 and 8, preferably comprised between 5 and 7, such as 6.
  • the phosphonic derivative of formula (I) is phytic acid.
  • the chelating compound can also be chosen from the amino acids.
  • amino acid means the amino acids and the phosphorylated derivatives thereof.
  • the amino acids can be of configuration L or D or the mixture thereof, preferably of configuration L or the mixture DL.
  • the amino acids are preferably chosen from alpha-amino acids and more particularly from proteinogenic amino acids.
  • phosphorylated derivative means an amino acid carrying an alcohol function OH of which the hydrogen has been substituted with a phosphoryl function of formula PO 3 H2.
  • the amino acid is chosen from serine, O-phosphoserine and histidine.
  • the chelating compound is chosen from phytic acid, serine, O-phosphoserine and histidine.
  • the concentration in chelating compound(s) in the composition B2 varies between 0.1% and 25% by weight, preferably between 0.5% and 20% by weight, preferably between 1% and 15% by weight, in relation to the total weight of the composition B2.
  • the concentration in each chelating compound in the composition B2 varies between 0.1% and 25% by weight, preferably between 2% and 20% by weight, preferably between 3% and 15% by weight, in relation to the total weight of the composition B2.
  • the concentration in each chelating compound in the composition B2 varies between 0.1% and 25% by weight, preferably between 1% and 20% by weight, preferably between 1 .3% and 20% by weight, in relation to the total weight of the composition B2.
  • the mixture of chelating agents can designate a mixture of different phosphonic derivatives of formula (I), or a mixture of different amino acid derivatives, or a mixture of phosphonic derivative(s) of formula (I) and of amino acid compound(s).
  • the cosmetically acceptable medium can be aqueous.
  • the aqueous phase of the compositions B1 and/or B2 (or of the composition according to the invention) comprises water, and can further comprise other solvents miscible in water.
  • the solvents miscible in water comprise short-chain mono-alcohols for example C1 -C4 such as ethanol or isopropanol; diols or polyols such as ethyleneglycol, 1 ,2- propyleneglycol, 1 ,3-butylene glycol, hexyleneglycol, diethyleneglycol, dipropylene glycol, 2-ethoxyethanol, diethylene glycol monomethylether, triethylene glycol monomethylether and sorbitol.
  • C1 -C4 such as ethanol or isopropanol
  • diols or polyols such as ethyleneglycol, 1 ,2- propyleneglycol, 1 ,3-butylene glycol, hexyleneglycol, diethyleneglycol, dipropylene glycol,
  • compositions B1 and/or B2 can also comprise at least one non-water-miscible organic phase, known as a fatty phase.
  • a fatty phase This generally includes one or a plurality of hydrophobic compounds rendering said phase non- miscible in water.
  • Said phase can be liquid (in the absence of a structuring agent) at ambient temperature (20-25°C).
  • the organic liquid phase non-miscible in water according to the invention generally comprises at least one volatile oil and/or one non volatile oil and optionally at least one structuring agent.
  • Oil means a fatty body that is liquid at ambient temperature (25 °C) and atmospheric pressure (760mm Hg namely 10 5 Pa). The oil may be volatile or non-volatile.
  • compositions B1 and/or B2 can also comprise at least one solid fat.
  • this solid fat is chosen from waxes and pasty fats and mixtures thereof.
  • deodorant agent denotes in the context of the present invention any agent, alone, with the effect of masking, absorbing, enhancing and/or reducing the unpleasant odor resulting from the decomposition of human sweat.
  • bacteriostatic agents or bactericidal agents acting on germs of underarm odor such as 2,4,4'-trichloro-2'-hydroxydiphenylether (®Triclosan), 2,4-dichloro-2'- hydroxydiphenylether, 3’,4’,5’-trichlorosalicylanilide,1-(3’,4’-dichlorophenyl)-3-(4’- chlorophenyl)urea ( ⁇ Triclocarban) or 3,7,11-trimethyldodeca-2, 5,10-trienol ( ⁇ Farnesol); quaternary ammonium salts such as cetyltrimethylammonium salts, cetylpyridinium salts; polyols such as those of the glycerin type, 1 ,3-propanediol (ZEMEA PROPANEDIOL® sold by Dupont Tate and Lyle Bioproducts),
  • the additional deodorant agents can be present preferably in the compositions according to the invention in mass concentrations ranging from 0.01% to 10% by weight in relation to the total weight of the composition.
  • compositions B1 and/or B2 can also comprise at least one additional antiperspirant agent.
  • antiperspirant agent denotes any substance, alone, with the effect of reducing sweat flow, reducing the damp sensation on the skin associated with human sweat, masking human sweat.
  • additional antiperspirant agents mention can be made in particular of aluminum and/or zirconium antiperspirant salts or complexes, preferably chosen from aluminum halohydrates; aluminum and zirconium halohydrates, zirconium hydroxychloride and aluminum hydroxychloride complexes with or without an amino acid such as those described in patent US-3792068.
  • aluminum salts mention can be made in particular of aluminum chlorhydrate in activated or non-activated form, aluminum chlorohydrex, aluminum chlorohydrex polyethyleneglycol complex, aluminum chlorohydrex propyleneglycol complex, aluminum dichlorohydrate, aluminum dichlorohydrex polyethyleneglycol complex, aluminum dichlorohydrex propyleneglycol complex, aluminum sesquichlorohydrate, aluminum sesquichlorohydrex polyethylene glycol complex, aluminum sesquichlorohydrex propyleneglycol complex, aluminum sulfate buffered by aluminum and sodium lactate.
  • aluminum and zirconium salts mention can be made in particular of aluminum zirconium octachlorohydrate, aluminum zirconium pentachlorohydrate, aluminum zirconium tetrachlorohydrate, aluminum zirconium trichlorohydrate.
  • Zirconium hydroxychloride and aluminum hydroxychloride complexes with an amino acid are generally known under the name ZAG (when the amino acid is glycine).
  • ZAG when the amino acid is glycine.
  • Aluminum sesquichlorohydrate is in particular sold under the trade name REACH 301® by SUMMITREHEIS.
  • zirconium hydroxychloride and aluminum hydroxychloride with an amino acid such as glycine having for INCI name: ALUMINUM ZIRCONIUM TETRACHLOROHYDREX GLY for example that sold under the trade name REACH AZP-908-SUF® by SUMMITREHEIS.
  • compositions B1 and/or B2 (or the composition according to the invention) comprise less than 5% by weight of aluminum salt, preferable less than 3% by weight, preferably less than 1% by weight.
  • the compositions B1 and/or B2 (or the composition according to the invention) are totally free of aluminum salt.
  • the cosmetic compositions B1 and/or B2 can furthermore comprise cosmetic additives chosen from among opacifiers, stabilizers, preservatives, perfume, solar filters, cosmetic active agents, fillers, suspension agents, sequestrants, coloring materials or any other ingredient routinely used in cosmetics for this type of application.
  • cosmetic additives chosen from among opacifiers, stabilizers, preservatives, perfume, solar filters, cosmetic active agents, fillers, suspension agents, sequestrants, coloring materials or any other ingredient routinely used in cosmetics for this type of application.
  • an expert in the subject will take care to choose the optional compound(s) in such a way that the advantageous properties intrinsically associated with the composition B1 or B2 or with the composition according to the invention are not altered, or are not substantially altered, by the envisaged additive(s).
  • compositions B1 and/or B2 can independently of one another be presented in any of the dosage forms conventionally used for topical application and particularly in the form of aqueous gels, aqueous or hydroalcoholic solutions. They may, by the addition of a fatty or oil phase, be in the form of dispersions such as lotion, emulsions of liquid or semi-liquid consistency such as milk, obtained by dispersing a fatty phase in an aqueous phase (O/W) or conversely (W/O), or suspensions or emulsions of soft, semi-solid or solid consistency such as cream or gel, or multiple emulsions (W/O/W or O/W/O), microemulsions, ionic and/or non-ionic type vesicle dispersions, or wax/aqueous phase dispersions.
  • These compositions B1 and/or B2 are prepared according to the usual methods.
  • compositions B1 and/or B2 may be particularly packaged in pressurized form in an aerosol device or in a pump bottle; packaged in a device equipped with a perforated wall particularly a grid; packaged in a device equipped with a roll-on applicator; packaged in stick form, in loose or compact powder form.
  • they contain the ingredients generally used in this type of products and well-known to those skilled in the art.
  • the compositions B1 and/or B2 or the composition according to the invention may be solid particularly in stick form.
  • compositions B1 and/or B2 or the composition according to the invention are pressurized and packaged in an aerosol device, in particular comprising at least one propellant.
  • the propellant used is chosen preferably from dimethylether, volatile hydrocarbons such as propane, isopropane, n-butane, isobutane, n-pentane and isopentane and mixtures thereof, optionally with at least one chlorinated and/or fluorinated hydrocarbon; of the latter, mention may be made of the compounds sold by Dupont de Nemours under the trade names Freon® and Dymel®, and in particular monofluorotrichloromethane, difluorodichloromethane, tetrafluorodichloroethane and 1 ,1 -difluoroethane particularly sold under the trade name DYMEL 152 A® by DUPONT.
  • volatile hydrocarbons such as propane, isopropane, n-butane, isobutane, n-pentane and isopentane and mixtures thereof, optionally with at least one chlorinated and/or fluorinated hydrocarbon; of the latter, mention may be
  • Carbon dioxide, nitrous oxide, nitrogen or compressed air may also be used as a propellant.
  • the propellant is chosen from the volatile hydrocarbons.
  • the propellant is chosen from isopropane, n-butane, isobutane, pentane and isopentane and mixtures thereof.
  • the weight ratio between the liquid phase and the propellant gas varies in a ratio from 5/95 to 50/50, preferably from 10/90 to 40/60, and more preferably from 15/85 to 30/70.
  • the propellant concentration generally varies from 5 to 95% by pressurized mass and more preferentially from 50 to 85% by mass in relation to the total mass of the composition B1 and/or B2 or of the pressurized composition according to the invention.
  • the dispensing means forming part of the aerosol device, generally consist of a dispensing valve controlled by a dispensing head, in turn comprising a nozzle via which the composition according to the invention, or the mixture of the composition B1 and of the composition B2, is sprayed.
  • the container containing each pressurized composition may be opaque or transparent. It may be made of glass, polymeric or metal material, optionally coated with a layer of protective varnish.
  • Example 1 Preparation of compositions according to the invention and comparative compositions
  • compositions C1 -C5 according to the invention and the comparative compositions CC7-CC11 are prepared according to the following protocol:
  • a solution of one or more chelating compounds is prepared using a commercial solution(s), and the mass concentration of the chelating compound(s) is optionally adjusted to 10% or 15% by adding of a suitable quantity of water (10% or 15% by mass corresponding to 10 g or 15 g of active material for 100 g of composition). The pH of this solution is then adjusted by the adding of a suitable volume of a sodium silicate solution.
  • a suitable quantity of water 10% or 15% by mass corresponding to 10 g or 15 g of active material for 100 g of composition.
  • the pH of this solution is then adjusted by the adding of a suitable volume of a sodium silicate solution.
  • CC14 To 500 mI_ of a solution of disodium metasilicate (sold under the trade name SODIUM METASILICATE ANHYDROUS GRANULES OR POWDER by SILMACO) with a mass concentration in AM of 11.1% are quickly added 250 pL of an aqueous solution of hydrochloric acid at 37% in AM (sold under the trade name ACIDE CHLORHYDRIQUE 37% (aqueous solution at a concentration of 37%) by CARLO ERBA). The pH is then adjusted to 4.6 by the adding of 1920 pL of a solution at 1 mol/L of sodium hydroxide (sold under the trade name SODIUM HYDROXYDE EN SOLUTION by MERCK).
  • CC15 To 500 pL of a solution of disodium metasilicate (sold under the trade name SODIUM METASILICATE ANHYDROUS GRANULES OR POWDER by SILMACO) with a mass concentration in AM of 11 .1% are quickly added 250 pL of an solution of hydrochloric acid at 37% in AM (sold under the trade name ACIDE CHLORHYDRIQUE 37% (aqueous solution at a concentration of 37%) by CARLO ERBA), followed by the adding of 14 pL of ethanol. The pH is then adjusted to 3.7 by the adding of 630 pL of a solution at 1 mol/L of sodium hydroxide (sold under the trade name SODIUM HYDROXYDE EN SOLUTION by MERCK).
  • Example 2 In-vitro evaluation of the anti-perspirant activity of the compositions of example 1
  • the anti-perspirant activity of the compositions described in example 1 was evaluated in-vitro by a microfluidic method such as described in W02014/170174.
  • This method makes it possible to qualitatively a potential anti-perspirant activity via the physical-chemical route of a mimetic active ingredient of aluminum salts (ACH). It makes it possible to model in vitro the physics, and consequently the specificity of the flows of the sweat such as they are produced in vivo. It thus makes it possible to qualitatively observe the interactions (formation of floes, aggregates and clogs%) between the active ingredients in solution and the constituents of sweat in mimetic conditions of sweating. The formation of a clog in contact with the channels that enclose on the one hand sweat, and on the other hand the compound to be evaluated, indicates that the compound to be evaluated effectively blocks the passage of the sweat and therefore has an anti-perspirant activity.
  • the microsystem manufactured from PDMS includes a main channel intended to receive the anti-perspirant (55 pm high and 400 pm wide) and a straight channel (55 pm high and 300 pm wide) into which is injected an artificial sweat model that mimics the sweat channel.
  • PDMS polydimethylsiloxane
  • the flows are controlled using a syringe pump.
  • the setpoint flow rate of sweat is 0.1 nL/s, and that of the anti-perspirant channel 1 nL/s.
  • the fluids flow at a controlled flow rate in a laminar flow and the interactions thereof are observed using optical microscopy. An image is recorded every 15 seconds for 30 minutes.
  • a synthetic sweat was prepared such as described in the following table:
  • VWR ( 5) sold under the trade name Ibumin fraction V by MERCK
  • compositions C1 to C5 according to the invention lead to the formation of a plug such as observed in the case of the use of aluminum salts (comparative composition CC13).
  • the formation of these plugs is characteristics of the good anti-perspirant properties of these compositions.

Abstract

La présente invention concerne des compositions de formation d'électrodes, l'utilisation desdites compositions de formation d'électrodes dans un procédé de fabrication d'électrodes, lesdites électrodes et des dispositifs électrochimiques tels que des batteries secondaires comprenant lesdites électrodes.
PCT/EP2020/071731 2019-08-02 2020-07-31 Procédé de prévention et/ou de traitement de la transpiration et composition associée WO2021023673A1 (fr)

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FR1908897A FR3099367B1 (fr) 2019-08-02 2019-08-02 Procédé de prévention et/ou traitement de la transpiration et composition associée
FRFR1908897 2019-08-02

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR3119321A1 (fr) * 2021-02-04 2022-08-05 L'oreal Poudre cosmétique de prévention et/ou traitement de la transpiration et composition associée

Citations (4)

* Cited by examiner, † Cited by third party
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US3792068A (en) 1971-04-02 1974-02-12 Procter & Gamble Dry powder aerosol antiperspirant composition incorporating dry powder antiperspirant active complex and process for its preparation
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