WO2021018216A1

WO2021018216A1 - Electrical pulse device for treating tumor

Info

Publication number: WO2021018216A1
Application number: PCT/CN2020/105582
Authority: WO
Inventors: 王海峰; 罗中宝
Original assignee: 上海睿刀医疗科技有限公司
Priority date: 2019-07-30
Filing date: 2020-07-29
Publication date: 2021-02-04
Also published as: CN112294424A

Abstract

An electrical pulse device (100) for treating a tumor, the device comprising: a direct-current power supply (6), a conversion circuit (8), a control circuit (4) and an electrical coupling optical fiber apparatus (5). The control circuit (4) is configured to control the conversion circuit (8) to convert a direct-current voltage from the direct-current power supply (6) into a bipolar pulse voltage. The electrical coupling optical fiber apparatus (5) is coupled to the control circuit (4) and the conversion circuit (8), and is configured to convert a first electrical signal, from the control circuit (4) and located in a first voltage domain, into an optical signal, transmit the optical signal via an optical fiber, convert the transmitted optical signal into a second electrical signal located in a second voltage domain that is different from the first voltage domain, and transmit the second electrical signal to the conversion circuit (8).

Description

Electric pulse equipment for treating tumor

Technical field

The present disclosure relates to the field of electricity, and more specifically to electronic medical devices.

Background technique

Tumors, especially malignant tumors, are the main diseases that endanger human health. The traditional therapy for tumors and the newly developed therapy are thermal ablation physical therapy characterized by minimally invasive ablation. Due to the limitations of indications, contraindications, treatment side effects, thermal effects and other factors, its clinical application has certain limitations. In recent years, with the continuous development of pulsed bioelectricity, electric field pulses have attracted the attention of researchers due to their non-thermal and minimally invasive biomedical effects. Among them, irreversible electroporation treatment of tumors is fast, controllable, visible, and The advantages and characteristics of selectivity and non-thermal mechanism have attracted wide attention from researchers in the field of bioelectricity at home and abroad, and are gradually applied to clinical treatment of tumors.

The pulses output by conventional equipment for treating tumors are unipolar pulses. Unipolar pulses are likely to cause muscle contraction when acting on human tissues, increasing the pain of the patient and increasing the difficulty of treatment, and the electric field of the unipolar pulses is not uniform, and there are blind areas for ablation, making the ablation effect not very good.

In addition, the conventional equipment used to treat tumors also has the risk of medical accidents caused by serial current between devices.

Summary of the invention

According to an embodiment of the present disclosure, an improved device for treating tumors is provided.

In one aspect of the present disclosure, an electric pulse device for treating tumors is provided. The electric pulse equipment includes: a direct current power supply, a conversion circuit, a control circuit and an electrical coupling optical fiber device. The control circuit is configured to control the conversion circuit to convert the DC voltage from the DC power supply into a bipolar pulse voltage. The electrically coupled optical fiber device is coupled to the control circuit and the conversion circuit, and is configured to convert the first electrical signal from the control circuit into an optical signal, transmit the optical signal via the optical fiber, and convert the transmitted optical signal into a second electrical signal, And the second electric signal is transmitted to the conversion circuit.

In some embodiments, the isolation voltage of the electrically coupled optical fiber device is in the range of 3kV to 12kV; and the isolation voltage of the conversion circuit is in the range of 500V to 2kV.

In some embodiments, the conversion circuit includes a driver chip, and the ground input terminal and the ground output terminal of the driver chip are configured as a common ground.

In some embodiments, the conversion circuit includes a drive chip, a first inverter branch, and a second inverter branch connected in parallel with the first inverter branch, and the first inverter branch includes a series connection The first insulated gate bipolar transistor and the second insulated gate bipolar transistor, the second inverter branch includes a third insulated gate bipolar transistor and a fourth insulated gate bipolar transistor connected in series.

In some embodiments, the control circuit is coupled to the conversion circuit and is operable to cause the driving chip to alternately apply a first pair of positive driving signals and negative driving signals to the first insulated gate bipolar A transistor and the second insulated gate bipolar transistor, and a second pair of positive drive signals and negative drive signals opposite to the first pair of positive drive signals and negative drive signals are alternately applied to the third insulated gate double A polar transistor and the fourth insulated gate bipolar transistor so that the conversion circuit generates the bipolar pulse voltage.

In some embodiments, the control circuit is operable to receive a first input indicative of a voltage, and adjust the DC power source based on the received first input to generate the adjusted DC voltage.

In some embodiments, the conversion circuit further includes a voltage detection device that is operable to detect the direct current voltage.

In some embodiments, the control circuit may be operable to: receive the detected DC voltage; determine that the detected DC voltage exceeds a threshold; and in response to the detected DC voltage exceeding the threshold, cause the drive chip to turn off the The first insulated gate bipolar transistor, the second insulated gate bipolar transistor, the third insulated gate bipolar transistor and the fourth insulated gate bipolar transistor.

In some embodiments, the control circuit is operable to receive a second input indicative of a frequency, and to cause the conversion circuit to adjust the frequency of the bipolar pulse voltage based on the received second input.

In some embodiments, the electric pulse device further includes: a bleeder resistor, coupled between the DC power supply and the conversion circuit and operable to bleed energy in the case of an emergency stop; an emergency stop switch device, coupled to The direct current power supply, the bleeder resistor, and the conversion circuit, and the emergency stop switch device is operable to disconnect the power from the direct current power supply to the converted circuit in response to the emergency stop switch being turned on Connect; turn off the DC power supply; and discharge energy through the discharge resistor.

It should be understood that the content described in the content of the invention is not intended to limit the key or important features of the embodiments of the present disclosure, nor is it intended to limit the scope of the present disclosure. Other features of the present disclosure will be easily understood by the following description.

Description of the drawings

With reference to the accompanying drawings and with reference to the following detailed description, the above and other features, advantages and aspects of the embodiments of the present disclosure will become more apparent. In the drawings, the same or similar reference signs indicate the same or similar elements, in which:

Figure 1 shows a schematic diagram of an example environment in which embodiments of the present disclosure may be implemented; and

Fig. 2 shows a partial schematic diagram according to an embodiment of the present disclosure.

Detailed ways

Hereinafter, embodiments of the present disclosure will be described in more detail with reference to the accompanying drawings. Although some embodiments of the present disclosure are shown in the drawings, it should be understood that the present disclosure can be implemented in various forms and should not be construed as being limited to the embodiments set forth herein. On the contrary, these embodiments are provided for Have a more thorough and complete understanding of this disclosure. It should be understood that the drawings and embodiments of the present disclosure are only used for exemplary purposes and are not used to limit the protection scope of the present disclosure.

In the description of the embodiments of the present disclosure, the term "including" and similar terms should be understood as open-ended inclusion, that is, "including but not limited to". The term "based on" should be understood as "based at least in part on". The term "one embodiment" or "the embodiment" should be understood as "at least one embodiment". The terms "first", "second", etc. may refer to different or the same objects. The following may also include other explicit and implicit definitions.

Generally speaking, electric pulse devices used to treat tumors usually use unipolar pulses to irreversibly destroy tumor tissues. The voltage applied to the tumor tissue is usually a high voltage pulse such as 3000V, and based on the targeted tumor type, shape, size, degree of malignancy, etc., the applied voltage value and pulse frequency can be selected accordingly.

However, conventional electric pulse equipment used to treat tumors has problems such as excessive treatment, unsatisfactory treatment effects, and even treatment accidents. The inventor found through research that the electrical pulse signal output by the conventional electrical pulse device has a spike waveform at the edge of the pulse, for example, see FIG. 3. For equipment used to treat tumors, these spike waveforms cause the electrical impulse equipment to output a voltage exceeding a predetermined value. For treatment voltages of up to thousands of volts, these spikes may cause the peak voltage to exceed the predetermined value by hundreds of volts, which will lead to unsatisfactory treatment effects, and in serious cases may even cause medical treatment such as irreversible damage to normal tissues. accident.

Hereinafter, embodiments of the present disclosure will be described in detail with reference to the drawings. Figure 1 shows a schematic diagram of an example environment 100 in which embodiments of the present disclosure may be implemented. The example environment 100 is shown as an electrical impulse device 100 for treating tumors.

The electric pulse device 100 includes a host computer 2, a control circuit 4, a high-voltage direct current power supply 6, a conversion circuit 8, a switching board 10,

electrode pins

22 and 24, auxiliary circuits and the like. Although a plurality of components or circuits are schematically shown in FIG. 1, it can be understood that this is only an illustration and does not limit the scope of the present disclosure. For example, in the embodiment of FIG. 1, some other components may be added between various components, or some components may be reduced from the embodiment of FIG. 1.

The host computer 2 may be a computing device such as a computer and a tablet computer. In some examples, the host computer 2 may only include a display screen and an input device. In still other examples, the host computer may only include input devices.

The control circuit 4 may include a CPU or an ARM processor. In some examples, the control circuit 4 may also be referred to as a lower circuit board or a lower board opposite to the upper computer 2. The control circuit 4 may be coupled to various components of the electric pulse device 100 in a wired or wireless manner as required to receive, process, and send data signals, so as to control each component of the electric pulse device 100.

The high-voltage DC power supply 6 can generate the required DC voltage based on the signal from the control circuit 4. For example, the high-voltage DC power supply 6 may convert a 220V AC mains voltage into a DC voltage of 800V to 3000V based on a signal from the control circuit 4. In other examples, the high-voltage DC power supply 6 may convert the AC mains voltage into a DC voltage lower than 800V such as 300V, 400V, 500V, 600V, or 700V, or convert the AC mains voltage into a DC voltage such as 3100V , 3300V, 3500V, 3700V or 4000V and other DC voltage higher than 3000V.

The conversion circuit 8 can convert the DC voltage from the high-voltage DC power supply 6 into pulse voltage based on the signal from the control circuit 4. In one example, the pulse voltage is a bipolar pulse voltage. By using bipolar pulse voltage, it can overcome the problems of uneven electric field caused by unipolar pulse voltage, the existence of ablation blind area, and the poor ablation effect, and it will not cause muscle atrophy, treatment pain and other problems.

For example, the pulse voltage may be a bipolar pulse voltage with an amplitude of 800V and a frequency of 100Hz. In another example, the pulse voltage may be a bipolar pulse voltage with an amplitude of 3000V and a frequency of 1000Hz. In an example, an energy storage capacitor C1 may be provided between the conversion circuit 8 and the high-voltage DC power supply 6 so that the conversion circuit 8 can obtain stable electric energy.

Although two specific bipolar pulse voltages are schematically shown above, it can be understood that this is only an illustration and does not limit the scope of the present disclosure. For example, the amplitude and frequency of the bipolar pulse voltage can be selected based on the targeted tumor type, shape, size, degree of malignancy and other factors.

The switch board 10 is coupled to the conversion circuit 8 and the control circuit 4 via a load resistor R2, and selectively switches the pulse voltage between the electrode pins 22 and 24 according to the control signal of the control circuit 4. The switch board 10 includes a first board 102 and a second board 104. Different electric potentials are applied between the first plate 102 and the second plate 104, thereby forming a voltage between the two. The direction between the first plate 102 and the second plate 104 can be reversed with the pulse waveform as needed.

The switch board 10 includes a first switch 106 and a second switch 108. The first switch 106 and the second switch 108 are coupled to and controlled by the control circuit 4. In one example, the first switch 106 and the second switch 108 may be relays. By connecting the first switch 106 and the second switch 108 to plates having different electric potentials, a high-voltage electric field can be formed between the electrode pins 22 and 24.

Although only two electrode needles are shown in the embodiment of FIG. 1, it can be understood that this is only an example and does not limit the scope of the present disclosure. Based on the targeted tumor type, shape, size, degree of malignancy and other factors, more electrode needles can be selected, for example, 4 electrode needles, which include two electrode needles with high potential and two electrode needles with low potential. In another example, 5, 7, or 8 electrode needles can be selected, and the potential of each electrode needle can be different.

In the embodiment of FIG. 1, the electric pulse device 100 also has a bleeder resistor R1. The bleeder resistor R1 is coupled between the high-voltage DC power supply 6 and the conversion circuit 8, and is operable to bleed the accumulated energy in the case of an emergency stop. During the operation of the electric pulse device 100, a doctor or user may need to perform an emergency stop operation on the electric pulse device 100 with high voltage due to an emergency, that is, an emergency stop.

Therefore, in an embodiment of the present disclosure, the electric pulse device 100 also has an emergency stop switch device. The emergency stop switch device may include, for example, a first switch S1, a second switch S2, a third switch S3, and a fourth switch S4. The emergency stop switch device is coupled to the high-voltage DC power supply through the fourth switch S4, to the bleeder resistor through the first switch S1, and to the conversion circuit 8 through the second switch S2 and the third switch S4.

The emergency stop switch device is operable to disconnect the electrical connection from the high-voltage direct current power supply 6 to the conversion circuit 8 by opening the second switch S2 and the third switch S3 in response to the emergency stop switch being turned on (for example, a mechanical button is pressed) , The high-voltage DC power supply 6 is turned off by closing the fourth switch S4, and the discharge resistor R1 is turned on by closing the first switch S1 to discharge energy. In an example, the discharge resistor R1 can be turned on by closing the first switch S1 after a certain period of time after the high-voltage direct current power supply 6 is turned off to discharge energy.

In the example of FIG. 1, the electric pulse device 100 further includes a foot switch S5 coupled between the switching board 10 and the switching circuit 8. When a doctor or user uses an electric pulse therapy device, it is not desired that the electrode needle always applies an electric field, but only applies an electric field during treatment. In some examples, even during treatment, the electrode needle is not expected to always apply an electric field, but only when the electrode needle is in place (for example, inserted into a specific position in human tissue). Therefore, a switch is needed to control the application of the electric field. Compared with the conventional hand-push switch, the use of the foot switch S5 can prevent the doctor from touching the switch with his hand during treatment, which may cause bacteria to be contaminated, thereby avoiding the risk of wound infection. In addition, by using the foot switch S5, the doctor does not need to rely on outsiders to control the switch, making the treatment more convenient.

Fig. 2 shows a partial schematic diagram according to an embodiment of the present disclosure. In order to facilitate understanding and description, some components in FIG. 1 are not shown here to avoid affecting the description of important components. This does not mean that some components in FIG. 1 do not exist or can be omitted in the embodiment of FIG. 2.

The high-voltage DC power supply 6 provides a DC voltage V _A to the conversion circuit 8. The conversion circuit 8 includes a driving chip 80 and an inverter circuit. The inverter circuit includes a first inverter branch and a second inverter branch. The first inverter branch includes a first IGBT S1 and a second IGBT S2 coupled in series between a high voltage terminal V _A and a ground voltage terminal V _B , and the second inverter branch includes a high voltage terminal V _A and a ground voltage The third IGBT S3 and the fourth IGBT S4 are coupled in series between the terminal V _B.

The control circuit 4 sends a control signal to the driving chip 80, so that the driving chip 80 controls the turning on and off of the IGBT in the inverter circuit. For example, at one moment, the driving chip 80 turns on the first IGBT S1 and the fourth IGBT S4, and turns off the second IGBT S2 and the third IGBT S3, so that the first plate of the switch board 10 is applied with a high voltage, and the switch board The first plate of 10 is applied with a low voltage. At the next moment, the driving chip turns on the second IGBT S2 and the third IGBT S3, and turns off the first IGBT S1 and the fourth IGBT S4, so that the first plate of the switch board 10 is applied with a low voltage, and the first board of the switch board 10 is A high voltage is applied to a board.

However, the inventors discovered through research that when the IGBT is switched, the upper IGBT and the lower IGBT are simultaneously turned on for a short time. For example, the first IGBT S1 and the second IGBT S2 are turned on at the same time, which causes a short circuit in the first inverter branch. This is because the parasitic capacitance between the gate and collector of the IGBT will produce a very high transient voltage change (dv/dt) during the turn-off of the IGBT, which will cause the voltage between the gate and the collector to rise. Turn on the IGBT.

Although this short-circuit time is relatively short, it still causes burrs or spikes in the waveform output by the electrode needle. At the beginning of the pulse jump, there is a small pulse spike. The small pulse spike can be hundreds or even thousands of volts in high-voltage applications such as electric pulse tumor therapy equipment. This undesired high pressure may cause normal cells to be irreversibly destroyed.

In addition, for the electric pulse therapy device, since the upper and lower IGBTs are turned on at the same time to form a short circuit, the short circuit will generate considerable heat, thereby affecting the service life of the inverter circuit. In severe cases, the short circuit may even cause the IGBT to collapse and cannot be used.

In response to the above problem, in an embodiment of the present disclosure, the driving chip 80 alternately applies the first pair of positive driving signals and negative driving signals to the first IGBT S1 and the second IGBT S2 in response to the control signal of the control circuit 4. And the second pair of positive drive signals and negative drive signals are alternately applied to the third IGBT S3 and the fourth IGBT S4, so that the conversion circuit generates a bipolar pulse voltage.

For example, at one moment, the driver chip 80 provides a voltage of +15V to the first IGBT S1, a voltage of -5V to the second IGBT S2, a voltage of -5V to the third IGBT S3, and a voltage of +15V The voltage is supplied to the fourth IGBT S4. At the next moment when the pulse signal jumps, the driver chip 80 provides a voltage of -5V to the first IGBT S1, a voltage of +15V to the second IGBT S2, and a voltage of +15V to the third IGBT S3, and The voltage of -5V is supplied to the fourth IGBT S4, and thus alternately reciprocates.

Although +15V and -5V are used as examples in the above description, this is only for illustration and does not limit the scope of the present disclosure. In an example, the positive drive signal in the first pair of positive drive signals and negative drive signals is selected from the range from 0V to +18V, and the negative drive signal in the first pair of positive drive signals and negative drive signals is selected from 0V to +18V. -8V range.

In another example, the positive drive signal in the first pair of positive drive signals and negative drive signals is selected from the range from 0V to +15V, and the negative drive signal in the first pair of positive drive signals and negative drive signals is selected from 0V To the range of -5V.

In yet another example, the positive drive signal in the first pair of positive drive signals and negative drive signals is selected from the range from 0V to +15V, and the negative drive signal in the first pair of positive drive signals and negative drive signals is selected from 0V To the range of -8V.

In yet another example, the positive drive signal in the first pair of positive drive signals and negative drive signals is selected from the range from 0V to +18V, and the negative drive signal in the first pair of positive drive signals and negative drive signals is selected from 0V. To the range of -5V.

By using a pair of positive and negative drive signals to be applied to the inverter branch, the short-circuit problem caused by the instantaneous simultaneous conduction of the upper IGBT and the lower IGBT can be effectively prevented, and the pulse waveform output by the electrode needle is accordingly made more ideal. For example, the pulse waveform is smooth and complete without any transient glitches or spikes.

Although in the embodiment of the present disclosure, paired positive and negative driving signals are applied to the inverter branch to prevent the occurrence of short circuit problems caused by the instantaneous simultaneous conduction of the upper IGBT and the lower IGBT, it is understood that this is only an example, and It does not limit the scope of the present disclosure. In other examples, the upper IGBT and the lower IGBT can be prevented by increasing the gate resistance of the IGBT, the capacitance between the gate and the collector of the IGBT, or setting an additional transistor between the gate and the emitter of the IGBT. Short-circuit problem caused by instantaneous simultaneous conduction.

In addition, the control circuit 4 is operable to receive a first input indicative of a voltage, and adjust the DC power source based on the received first input to generate an adjusted DC voltage. For example, for a specific type of tumor, the upper computer 2 can correspondingly input a voltage value to the control circuit 4, and the control circuit 4 receives the input, and based on the received input causes the conversion circuit 8 to adjust the value of the bipolar pulse voltage, for example Adjust from 1000V to 1500V.

It can be seen that the control circuit 4 controls the conversion circuit 8 to operate in the high voltage domain coupled to the high DC voltage through the IGBT, while the control circuit 4 itself operates in the low voltage domain. In the conventional solution, the control circuit can operate in a first voltage domain, and the conversion circuit can operate in a second voltage domain, and the conversion circuit can be connected to high voltage through an IGBT, where the first voltage domain is such as from 0V to 12V, and The second voltage domain can be from 0V to 20V.

In this case, it is possible for the conversion circuit operating in the second voltage domain to electrically connect the high-voltage voltage string to the control circuit operating in the first voltage domain through a physical connection. The voltage of the string power may be much higher than the withstand voltage of the control circuit operating in the first voltage domain, thereby causing damage to the control circuit. In severe cases, it may even be connected to other parts of the therapeutic apparatus, which may bring safety hazards to doctors or patients.

Therefore, it is necessary to isolate the conversion circuit and the control circuit. In the conventional scheme, a 10M isolation optocoupler can be set between the control circuit and the conversion circuit. However, the inventor found through research that although the isolation voltage of 10M isolated optocoupler, such as 3750V, is sufficient for electrical isolation, there is still a phenomenon of small creepage distance and electrical clearance, which is likely to cause problems such as spark breakdown . After the fire breakdown, the control circuit is still easy to damage and cause safety hazards.

In other examples, the 10M isolation optocoupler is not used, but the drive chip in the conversion circuit is electrically isolated. For example, the voltage of the input terminal of the driving chip is usually located in the first voltage domain, and the voltage of the output terminal of the driving chip is usually located in the second voltage domain higher than the first voltage domain. The input terminal and the output terminal are isolated by the voltage isolation configuration of the driver chip. However, the performance of electrical isolation of driving chips, especially positive and negative voltage driving chips, is limited. For example, the isolation voltage of the positive and negative voltage driving chip can only reach 1200V. For the medical tumor treatment instrument, this is not enough to bear its full operating voltage or can only limit the operating range of the medical tumor treatment instrument to within 1200V.

In an example of the present disclosure, an electrically coupled optical fiber device 5 is provided between the control circuit 4 and the conversion circuit 8. The electrically coupled optical fiber device 5 is configured to convert the first electrical signal from the control circuit 4 into an optical signal, transmit the optical signal via an optical fiber, convert the transmitted optical signal into a second electrical signal, and transmit the second electrical signal To the conversion circuit.

In an example, the isolation voltage of the electrically coupled optical fiber device 5 is in the range of 3 kV to 12 kV, so that the control circuit 4 can be prevented from being damaged by a high voltage of 3000V. In an example, the isolation voltage of the conversion circuit 8 may be in the range of 500V to 2kV. By using the electrically coupled optical fiber device 5, the conversion circuit and the control circuit can be electrically isolated effectively, and the problem of small creepage distance and electric clearance can be avoided.

In an example, the conversion circuit 8 may include a positive and negative voltage driving chip 80. The input terminal of the positive and negative voltage driving chip 80 is located in a first voltage domain, and the voltage of the output terminal of the driving chip 80 is located in a second voltage domain higher than the first voltage domain. In this example, due to the existence of the electrically coupled optical fiber device 5, the input terminal and the output terminal of the positive and negative voltage driving chip 80 can be shared, thereby forming a safe and reliable high-voltage high-power inverter IGBT driving topology.

In an example, the conversion circuit 80 further includes a voltage detection device 82. The voltage detection device 82 is operable to detect a direct current voltage. Although it is shown in FIG. 2 that the conversion circuit 80 includes the voltage detection device 82, it can be understood that this is only an illustration and does not limit the protection scope of the present disclosure. The voltage detection device 82 may exist independently of the conversion circuit 80.

For example, a separate voltage detection device 82 can be provided to detect the DC voltage of the emitter and collector of the IGBT, and transmit the detected voltage to the control circuit 4. The control circuit 4 is operable to receive the detected DC voltage, determine that the detected DC voltage exceeds the threshold, and in response to the detected DC voltage exceeding the threshold, so that the driving chip 80 turns off the first IGBT S1, the second IGBT S2, and the second IGBT S2. Three IGBT S3 and the fourth IGBT S4.

For example, when the detected DC voltage exceeds the 7V threshold, the voltage detection device 82 determines that the DC voltage exceeds the threshold and there is a short circuit in this case. The driving chip 80 turns off the first IGBT S1, the second IGBT S2, the third IGBT S3, and the fourth IGBT S4 to protect the inverter circuit from collapse.

Although the protection circuit is shown as a part of the driving chip in the example of FIG. 2, it can be understood that this is only an example and does not limit the protection scope of the present disclosure. In some other examples, a separate protection circuit can be provided. When the voltage detection device 82 determines that the DC voltage exceeds the threshold and there is a short circuit in this case, the drive chip 80 causes the separate protection circuit to turn off the first IGBT S1 and the second IGBT S2. , The third IGBT S3 and the fourth IGBT S4 to protect the inverter circuit from collapse.

In one example, the control circuit 4 is operable to receive a second input indicating the frequency, and based on the received second input, causes the conversion circuit 8 to adjust the frequency of the bipolar pulse voltage. For example, for a specific type of tumor, the upper computer 2 can input the frequency value to the control circuit 4 accordingly, and the control circuit 4 receives the input, and based on the received input, causes the conversion circuit 8 to adjust the frequency of the bipolar pulse voltage, for example Adjust from 100Hz to 150Hz.

Although the subject matter has been described in language specific to structural features and/or logical actions of the method, it should be understood that the subject matter defined in the appended claims is not necessarily limited to the specific features or actions described above. On the contrary, the specific features and actions described above are merely exemplary forms of implementing the claims.

Claims

An electric pulse device for treating tumors, which is characterized in that it comprises:

DC power supply (6);

Conversion circuit (8);

The control circuit (4) is configured to control the conversion circuit (8) to convert the DC voltage from the DC power supply into a bipolar pulse voltage; and

The electrically coupled optical fiber device (5) is coupled to the control circuit and the conversion circuit, and is configured to convert the first electrical signal from the control circuit into an optical signal, transmit the optical signal via an optical fiber, and The transmitted optical signal is converted into a second electrical signal, and the second electrical signal is transmitted to the conversion circuit.
The electric pulse equipment according to claim 1, wherein the isolation voltage of the electrically coupled optical fiber device (5) is in the range of 3kV to 12kV; and

The isolation voltage of the conversion circuit is in the range of 500V to 2kV.
The electric pulse device according to claim 1, wherein the conversion circuit comprises a driving chip, and the ground input terminal and the ground output terminal of the driving chip are configured as a common ground.
The electric pulse device according to claim 1, wherein the conversion circuit comprises a drive chip (80), a first inverter branch, and a second inverter branch connected in parallel with the first inverter branch , The first inverter branch includes a first insulated gate bipolar transistor (IGBT1) and a second insulated gate bipolar transistor (IGBT2) connected in series, and the second inverter branch includes a third insulated gate bipolar transistor (IGBT2) connected in series. Polar transistor (IGBT3) and fourth insulated gate bipolar transistor (IGBT4).
The electric pulse device according to claim 4, characterized in that the control circuit (4) is coupled to the conversion circuit and is operable to make the drive chip alternate the first pair of positive drive signals and negative drive signals Ground is applied to the first insulated gate bipolar transistor (IGBT1) and the second insulated gate bipolar transistor (IGBT2), and the second pair of positive and negative drive signals opposite to the first pair of positive drive signals A driving signal and a negative driving signal are alternately applied to the third insulated gate bipolar transistor (IGBT3) and the fourth insulated gate bipolar transistor (IGBT4) so that the conversion circuit (8) generates the Bipolar pulse voltage.
The electric pulse device of claim 1, wherein the control circuit is operable to receive a first input indicating a voltage, and adjust the DC power supply based on the received first input to generate the adjusted DC voltage.
The electric pulse device according to claim 1, wherein the conversion circuit further comprises a voltage detection device, and the voltage detection device is operable to detect the direct current voltage.
The electric pulse device according to claim 6, wherein the control circuit is operable to:

Receive the detected DC voltage;

Determine that the detected DC voltage exceeds the threshold; and

In response to the detected DC voltage exceeding the threshold, the driving chip is caused to turn off the first insulated gate bipolar transistor, the second insulated gate bipolar transistor, the third insulated gate bipolar transistor, and the first insulated gate bipolar transistor. Four insulated gate bipolar transistors.
The electrical impulse device according to claim 6, wherein the control circuit is operable to receive a second input indicating a frequency, and based on the received second input, cause the conversion circuit to adjust the bipolar The frequency of the sexual pulse voltage.
The electric pulse device according to claim 9, further comprising:

A bleeder resistor, coupled between the DC power supply and the conversion circuit and operable to bleed energy in the case of an emergency stop;

The emergency stop switch device is coupled to the DC power supply, the bleeder resistor and the conversion circuit, and the emergency stop switch device is operable as:

In response to the emergency stop switch being turned on, disconnect the electrical connection of the DC power supply to the converted circuit;

Turn off the DC power supply; and

The energy is discharged through the discharge resistor.