CN114041873B - High-frequency irreversible electroporation pulse ablation device with asymmetric waveform - Google Patents
High-frequency irreversible electroporation pulse ablation device with asymmetric waveform Download PDFInfo
- Publication number
- CN114041873B CN114041873B CN202111326236.0A CN202111326236A CN114041873B CN 114041873 B CN114041873 B CN 114041873B CN 202111326236 A CN202111326236 A CN 202111326236A CN 114041873 B CN114041873 B CN 114041873B
- Authority
- CN
- China
- Prior art keywords
- circuit
- voltage
- power supply
- switch
- storage capacitor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 238000002679 ablation Methods 0.000 title claims abstract description 40
- 238000004520 electroporation Methods 0.000 title claims abstract description 36
- 230000002427 irreversible effect Effects 0.000 title claims abstract description 36
- 239000003990 capacitor Substances 0.000 claims abstract description 64
- 238000004146 energy storage Methods 0.000 claims abstract description 62
- 239000011159 matrix material Substances 0.000 claims abstract description 22
- 230000007935 neutral effect Effects 0.000 claims description 16
- 238000001514 detection method Methods 0.000 claims description 10
- 238000004891 communication Methods 0.000 claims description 4
- 230000000747 cardiac effect Effects 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 6
- 230000001105 regulatory effect Effects 0.000 abstract 1
- 206010003658 Atrial Fibrillation Diseases 0.000 description 21
- 238000007599 discharging Methods 0.000 description 19
- 238000010586 diagram Methods 0.000 description 7
- 238000011282 treatment Methods 0.000 description 7
- 239000003814 drug Substances 0.000 description 6
- 230000005684 electric field Effects 0.000 description 6
- 210000001519 tissue Anatomy 0.000 description 6
- 238000000034 method Methods 0.000 description 5
- 238000002560 therapeutic procedure Methods 0.000 description 5
- 230000006378 damage Effects 0.000 description 4
- 229940079593 drug Drugs 0.000 description 4
- 238000013153 catheter ablation Methods 0.000 description 3
- 210000000170 cell membrane Anatomy 0.000 description 3
- 208000005189 Embolism Diseases 0.000 description 2
- 208000007536 Thrombosis Diseases 0.000 description 2
- 238000011298 ablation treatment Methods 0.000 description 2
- 230000003288 anthiarrhythmic effect Effects 0.000 description 2
- 230000010100 anticoagulation Effects 0.000 description 2
- 230000006907 apoptotic process Effects 0.000 description 2
- 206010003119 arrhythmia Diseases 0.000 description 2
- 230000006793 arrhythmia Effects 0.000 description 2
- 210000004027 cell Anatomy 0.000 description 2
- 238000005868 electrolysis reaction Methods 0.000 description 2
- 210000002837 heart atrium Anatomy 0.000 description 2
- 210000005003 heart tissue Anatomy 0.000 description 2
- 230000003902 lesion Effects 0.000 description 2
- 238000013507 mapping Methods 0.000 description 2
- 230000033764 rhythmic process Effects 0.000 description 2
- 238000001356 surgical procedure Methods 0.000 description 2
- 238000002604 ultrasonography Methods 0.000 description 2
- 206010008088 Cerebral artery embolism Diseases 0.000 description 1
- LTMHDMANZUZIPE-AMTYYWEZSA-N Digoxin Natural products O([C@H]1[C@H](C)O[C@H](O[C@@H]2C[C@@H]3[C@@](C)([C@@H]4[C@H]([C@]5(O)[C@](C)([C@H](O)C4)[C@H](C4=CC(=O)OC4)CC5)CC3)CC2)C[C@@H]1O)[C@H]1O[C@H](C)[C@@H](O[C@H]2O[C@@H](C)[C@H](O)[C@@H](O)C2)[C@@H](O)C1 LTMHDMANZUZIPE-AMTYYWEZSA-N 0.000 description 1
- 208000007101 Muscle Cramp Diseases 0.000 description 1
- 206010028851 Necrosis Diseases 0.000 description 1
- 208000001435 Thromboembolism Diseases 0.000 description 1
- 230000002785 anti-thrombosis Effects 0.000 description 1
- 239000003146 anticoagulant agent Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- NWIUTZDMDHAVTP-UHFFFAOYSA-N betaxolol Chemical compound C1=CC(OCC(O)CNC(C)C)=CC=C1CCOCC1CC1 NWIUTZDMDHAVTP-UHFFFAOYSA-N 0.000 description 1
- 229960004324 betaxolol Drugs 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 230000034994 death Effects 0.000 description 1
- LTMHDMANZUZIPE-PUGKRICDSA-N digoxin Chemical compound C1[C@H](O)[C@H](O)[C@@H](C)O[C@H]1O[C@@H]1[C@@H](C)O[C@@H](O[C@@H]2[C@H](O[C@@H](O[C@@H]3C[C@@H]4[C@]([C@@H]5[C@H]([C@]6(CC[C@@H]([C@@]6(C)[C@H](O)C5)C=5COC(=O)C=5)O)CC4)(C)CC3)C[C@@H]2O)C)C[C@@H]1O LTMHDMANZUZIPE-PUGKRICDSA-N 0.000 description 1
- 229960005156 digoxin Drugs 0.000 description 1
- LTMHDMANZUZIPE-UHFFFAOYSA-N digoxine Natural products C1C(O)C(O)C(C)OC1OC1C(C)OC(OC2C(OC(OC3CC4C(C5C(C6(CCC(C6(C)C(O)C5)C=5COC(=O)C=5)O)CC4)(C)CC3)CC2O)C)CC1O LTMHDMANZUZIPE-UHFFFAOYSA-N 0.000 description 1
- 238000002651 drug therapy Methods 0.000 description 1
- 230000007831 electrophysiology Effects 0.000 description 1
- 238000002001 electrophysiology Methods 0.000 description 1
- 210000003238 esophagus Anatomy 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 230000016507 interphase Effects 0.000 description 1
- 201000010849 intracranial embolism Diseases 0.000 description 1
- 238000000608 laser ablation Methods 0.000 description 1
- 230000003211 malignant effect Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000004118 muscle contraction Effects 0.000 description 1
- 230000002107 myocardial effect Effects 0.000 description 1
- 208000010125 myocardial infarction Diseases 0.000 description 1
- 230000017074 necrotic cell death Effects 0.000 description 1
- 210000005036 nerve Anatomy 0.000 description 1
- 238000013546 non-drug therapy Methods 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 238000011458 pharmacological treatment Methods 0.000 description 1
- 210000003105 phrenic nerve Anatomy 0.000 description 1
- 238000007674 radiofrequency ablation Methods 0.000 description 1
- 238000005057 refrigeration Methods 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 230000001052 transient effect Effects 0.000 description 1
- 230000002861 ventricular Effects 0.000 description 1
- PJVWKTKQMONHTI-UHFFFAOYSA-N warfarin Chemical compound OC=1C2=CC=CC=C2OC(=O)C=1C(CC(=O)C)C1=CC=CC=C1 PJVWKTKQMONHTI-UHFFFAOYSA-N 0.000 description 1
- 229960005080 warfarin Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
- A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
- A61B18/14—Probes or electrodes therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
- A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
- A61B18/1206—Generators therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00315—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for treatment of particular body parts
- A61B2018/00345—Vascular system
- A61B2018/00351—Heart
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00571—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for achieving a particular surgical effect
- A61B2018/00613—Irreversible electroporation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00636—Sensing and controlling the application of energy
- A61B2018/00773—Sensed parameters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00636—Sensing and controlling the application of energy
- A61B2018/00773—Sensed parameters
- A61B2018/00791—Temperature
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00636—Sensing and controlling the application of energy
- A61B2018/00773—Sensed parameters
- A61B2018/00839—Bioelectrical parameters, e.g. ECG, EEG
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
- A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
- A61B18/1206—Generators therefor
- A61B2018/128—Generators therefor generating two or more frequencies
Landscapes
- Health & Medical Sciences (AREA)
- Surgery (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- Otolaryngology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Plasma & Fusion (AREA)
- Physics & Mathematics (AREA)
- Heart & Thoracic Surgery (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Surgical Instruments (AREA)
Abstract
The invention discloses an asymmetric waveform high-frequency irreversible electroporation pulse ablation device, which comprises a high-voltage direct-current power supply, an energy storage capacitor module, a high-voltage discharge circuit, an asymmetric waveform pulse generation circuit, a switch matrix circuit, a catheter and a control system circuit, wherein the high-voltage direct-current power supply is connected with the energy storage capacitor module; the control system circuit is connected with the high-voltage direct-current power supply, the energy storage capacitor module, the high-voltage discharge circuit, the pulse generating circuit of the asymmetric waveform and the switch matrix circuit; the high-voltage direct-current power supply is connected with positive and negative direct-current double-circuit voltage which is controlled by a control system circuit and can be regulated; the energy storage capacitor module is connected with the output end of the high-voltage direct-current power supply in parallel; the high-voltage discharge circuit is connected with the energy storage capacitor module in parallel; the pulse generating circuit of the asymmetrical waveform outputs an asymmetrical high-frequency pulse signal through the half-bridge converter by using the input positive and negative direct current double-circuit voltage; the asymmetrical high-frequency pulse signals are connected with the guide pipe through the switch matrix circuit. The invention can obtain better irreversible electroporation effect when the energy is the same.
Description
Technical Field
The invention relates to the technical field of high-voltage pulse electric field ablation devices, in particular to a high-frequency irreversible electroporation pulse ablation device with an asymmetric waveform.
Background
Atrial fibrillation (atrial fibrillation) is the most common arrhythmia with a prevalence of about 2% and progressively increasing prevalence with age. The most serious complication of atrial fibrillation is thromboembolism, which can lead to stroke, myocardial infarction, etc., with stroke being the most common complication of atrial fibrillation death.
There are two broad categories of methods for treating atrial fibrillation, namely drug therapy and non-drug therapy. Atrial fibrillation published according to the Chinese medical Congress electrophysiology and pacing Congress: current awareness and treatment advice-2015, current pharmacological treatment of atrial fibrillation mainly includes: control ventricular rate, restore and maintain sinus rhythm, and antithrombotic therapy. Wherein the medicine therapy comprises anti-arrhythmia therapy and anticoagulation therapy, and the anti-arrhythmia therapy aims at preventing occurrence of atrial fibrillation, controlling rapid heart rate during atrial fibrillation, removing atrial fibrillation and maintaining sinus heart rate. Commonly used drugs include arrhythmia, digoxin, betaxolol, and coadamone. The anticoagulation treatment aims at preventing the formation of wall-attached thrombus in the atrium and preventing the falling-off of wall-attached thrombus in the atrium from causing the column embolism of other organs, in particular cerebral embolism, and the common medicine is warfarin.
Atrial fibrillation non-drug treatment comprises ablation treatment, surgical operation treatment, pacing treatment and the like, is suitable for patients with poor atrial fibrillation effect or unsuitable for drug treatment by a drug method, and can be cured by successful ablation treatment and surgical operation treatment.
Currently, catheter ablation is an effective means for patients with atrial fibrillation to restore and maintain sinus rhythm. Catheter ablation is based on radiofrequency energy, but there are other sources of energy as well (including cryo, ultrasound, laser ablation, etc.). However, these ablations based on heat/cold energy conduction have limitations that lack selectivity for destruction of tissue in the ablation region and rely on the catheter's force against the ablated tissue, so that adjacent esophageal, coronary, and phrenic nerves, etc. may be damaged. Certain complications exist in the perioperative period, and part of patients can relapse due to the catheter leaning effect, the focus depth and the like. The recurrence rate for radiofrequency ablation was reported to be 20-40% and for cryoablation 10-30%.
In recent years, the application of pulsed electric field ablation in the field of cardiac ablation has been explored at home and abroad, and favorable results have been obtained. Unlike conventional energy, pulsed electric field energy forms irreversible micropores in the cell membrane by transient discharge, causing apoptosis, achieving the purpose of non-thermal ablation, also known as irreversible electroporation (Irreversible electroporation, IRE). Electroporation ablation has been used as an effective means of destroying malignant tissue. Pulsed electric field ablation can theoretically damage myocardial cells without heating the tissue, and has cell/tissue selectivity, protecting critical structures around the ablated tissue.
Pulse ablation is based on the principle that a short dc high voltage pulse can create an electric field of several hundred volts in the range of several centimeters, which can cause damage to the cell membrane to form perforations. If the electric field formed at the cell membrane is greater than a threshold, the electroporation that is formed is irreversible, maintaining the stomata open. Resulting in necrosis or apoptosis. Therefore, pulse ablation is a non-thermal biological ablation, and can effectively avoid damage to blood vessels, nerves and esophagus unlike radio frequency, refrigeration, microwave and ultrasound.
An effective method of cardiac tissue ablation is currently ablation procedures using irreversible electroporation (Direct current irreversible electroporation, DC-IRE) with direct current. However, there are two problems with DC-IRE: i) Patients must be general anesthetized during DC-IRE surgery due to severe muscle contraction; ii) bubbles containing gaseous products are generated during DC-IRE surgery due to electrolysis. Irreversible electroporation with high frequency alternating current (High frequency irreversible electroporation, HF-IRE) can solve two problems with DC-IRE, since HF-IRE produces little muscle cramps and does not cause electrolysis. Studies have shown that irreversible electroporation of asymmetric high frequency waveforms can form lesions in cardiac tissue and that asymmetric high frequency waveforms produce deeper lesions than symmetric waveforms of the same energy or symmetric waveforms of the same charge.
Accordingly, those skilled in the art have focused their efforts on developing a high frequency irreversible electroporation pulse ablation device of asymmetric waveform.
Disclosure of Invention
In view of the above-mentioned drawbacks of the prior art, the present invention is to provide a novel high-frequency irreversible electroporation pulse ablation device for treating atrial fibrillation with asymmetric waveforms, which can obtain better irreversible electroporation effect when having the same energy.
In order to achieve the above object, the present invention provides an asymmetric waveform high frequency irreversible electroporation pulse ablation device, comprising a high voltage direct current power supply, an energy storage capacitor module, a high voltage discharge circuit, an asymmetric waveform pulse generating circuit, a switch matrix circuit, a catheter and a control system circuit; the control system circuit is connected with the high-voltage direct-current power supply, the energy storage capacitor module, the high-voltage discharge circuit, the pulse generating circuit of the asymmetric waveform and the switch matrix circuit; the high-voltage direct current power supply is configured to receive the control of the control system circuit and output adjustable positive and negative direct current double-circuit voltage; the energy storage capacitor module is connected with the output end of the high-voltage direct-current power supply in parallel; the energy storage capacitor module is connected with the output end of the high-voltage direct-current power supply in parallel; the high-voltage discharge circuit is connected with the energy storage capacitor module in parallel; the pulse generating circuit of the asymmetrical waveform is configured to output an asymmetrical high-frequency pulse signal through a half-bridge converter from the input positive and negative direct current two-way voltage; the asymmetric high frequency pulse signal is connected to the catheter through the switch matrix circuit.
Further, the high-voltage direct current power supply is provided with a positive output end, a negative output end and a neutral output end, the energy storage capacitor module comprises a first energy storage capacitor and a second energy storage capacitor, the positive output end of the high-voltage direct current power supply is connected with one end of the first energy storage capacitor, the other end of the first energy storage capacitor is connected with one end of the second energy storage capacitor and the neutral output end of the high-voltage direct current power supply, and the negative output end of the high-voltage direct current power supply is connected with the other end of the second energy storage capacitor.
Further, the input control end of the high-voltage direct-current power supply is in communication connection with the output control end of the control system circuit through RS232 or RS485, so that the output positive and negative direct-current double-circuit voltage is controlled.
Further, one end of the high-voltage discharge circuit is connected with one end of the first energy storage capacitor, the other end of the high-voltage discharge circuit is connected with the other end of the second energy storage capacitor, and a discharge input control end of the high-voltage discharge circuit is connected with a discharge output control end of the control system circuit.
Further, the high-voltage discharge circuit comprises a discharge switch and a discharge resistor which are connected in series, and a control end of the discharge switch is used as a discharge input control end of the high-voltage discharge circuit.
Further, the discharging switch is an insulated gate bipolar transistor, a collector of the discharging switch is connected with a positive output end of the high-voltage direct current power supply, an emitter of the discharging switch is connected with one end of the discharging resistor, the other end of the discharging resistor is connected with a negative output end of the high-voltage direct current power supply, and a gate of the discharging switch is used as a control end to be connected with a discharging output control end of the control system circuit.
Further, the pulse generating circuit of the asymmetric waveform comprises a first switch and a second switch, the first switch and the second switch are insulated gate bipolar transistors, a collector electrode of the first switch is connected with a positive output end of the high-voltage direct-current power supply, a neutral output end of the high-voltage direct-current power supply is used as a first output end of the asymmetric high-frequency pulse signal, an emitter electrode of the first switch is connected with a collector electrode of the second switch to be used as a second output end of the asymmetric high-frequency pulse signal, an emitter electrode of the second switch is connected with a negative output end of the high-voltage direct-current power supply, and gate electrodes of the first switch and the second switch are respectively used as a first driving end and a second driving end of the pulse generating circuit of the asymmetric waveform to be connected to the control system circuit.
Further, the control system circuit comprises a voltage and current signal acquisition unit and a temperature signal acquisition unit, wherein the voltage and current signal acquisition unit is used for acquiring voltage and current signals of the asymmetric high-frequency pulse signals output by the pulse generating circuit of the asymmetric waveform, and the temperature signal acquisition unit is used for acquiring electrode temperature signals of the catheter.
Further, the system also comprises an electrophysiological recorder connected with the switch matrix circuit, wherein the electrophysiological recorder is used for measuring potential signals of electrocardio before and after ablation.
Further, the system also comprises an electrocardiosignal detection circuit and a foot switch which are connected with the control system circuit, wherein the electrocardiosignal detection circuit and the foot switch are used for triggering/controlling and outputting the asymmetric high-frequency pulse signal.
The invention has the beneficial effects that:
the high-frequency irreversible electroporation pulse ablation device can output positive and negative asymmetric high-frequency pulse waveforms through an adjustable high-voltage direct-current power supply, a high-voltage discharge circuit, a half-bridge converter circuit, a switch matrix circuit, a control system circuit and the like which are capable of outputting positive and negative direct-current voltages.
The conception, specific structure, and technical effects of the present invention will be further described with reference to the accompanying drawings to fully understand the objects, features, and effects of the present invention.
Drawings
FIG. 1 is a schematic illustration of the configuration of an asymmetrically wave shaped high frequency irreversible electroporation pulse ablation apparatus in accordance with a preferred embodiment of the present invention;
FIG. 2 is a circuit diagram of a high voltage discharge circuit according to a preferred embodiment of the present invention;
FIG. 3 is a circuit diagram of a high voltage DC power supply and an energy storage capacitor according to a preferred embodiment of the present invention;
FIG. 4 is a circuit diagram of a half-bridge inverter according to a preferred embodiment of the present invention;
fig. 5 is a diagram of an output asymmetric pulse waveform according to a preferred embodiment of the present invention.
The pulse generation circuit comprises an 11-high-voltage direct-current power supply, a 12-second energy storage capacitor, a 13-first energy storage capacitor, a 14-high-voltage discharge circuit, a 15-asymmetric waveform pulse generation circuit, a 151-driving circuit, a 152-inverter circuit, a 16-switch matrix circuit, a 17-catheter, an 18-electrocardiosignal detection circuit, a 19-control system circuit, a 20-foot switch, a 21-electrophysiological recorder, a 101-positive pulse voltage, a 102-negative pulse voltage, a 201-positive pulse width, a 202-negative pulse width, a 203-inter-phase interval, a 204-pulse interval, a 205-pulse period length and a 206-pulse string length.
Detailed Description
The following description of the preferred embodiments of the present invention refers to the accompanying drawings, which make the technical contents thereof more clear and easier to understand. The present invention may be embodied in many different forms of embodiments and the scope of the present invention is not limited to only the embodiments described herein.
In the drawings, like structural elements are referred to by like reference numerals and components having similar structure or function are referred to by like reference numerals. The dimensions and thickness of each component shown in the drawings are arbitrarily shown, and the present invention is not limited to the dimensions and thickness of each component. The thickness of the components is exaggerated in some places in the drawings for clarity of illustration.
As shown in fig. 1, the present embodiment discloses a high-frequency irreversible electroporation pulse ablation apparatus for treating an asymmetric waveform of atrial fibrillation, which is used in the field of medical instruments, and includes: a high-voltage direct current power supply 11 with two-way output, a high-voltage discharge circuit 14, a pulse generating circuit 15 (specifically, a half-bridge inverter circuit is adopted) with an asymmetric waveform for high-frequency irreversible electroporation, a switch matrix circuit 16 and a control system circuit 19.
The technical scheme of the embodiment is a novel high-frequency irreversible electroporation pulse ablation device for treating atrial fibrillation, which can output a high-frequency pulse waveform with positive and negative asymmetry through an adjustable high-voltage direct-current power supply 11, a high-voltage discharging circuit 14, a half-bridge converter circuit, a switch matrix circuit 16, an electrocardiosignal detection circuit 18, a foot switch 20 and a control system circuit 19 which are capable of outputting positive and negative direct-current voltages by two paths, and simultaneously, a catheter has the functions of ablating the catheter and mapping the catheter. The specific process is that the control system sets the positive DC voltage amplitude and the negative DC voltage amplitude of the high-voltage DC power supply output, and the control system controls the IGBT1 and the IGBT2 (shown in figure 4) of the half-bridge converter to output asymmetric high-frequency Pulse signals Pulse1 (shown in figure 3) and Pulse2 (shown in figure 4).
As shown in fig. 1, a novel high-frequency irreversible electroporation pulse ablation apparatus for treating an asymmetric waveform of atrial fibrillation, comprising:
a high voltage dc power supply 11. The high-voltage direct-current power supply 11 is adjustable positive and negative direct-current double-circuit voltage output, and the output can be set through a control system. The hvdc power source 11 may output controllable positive and negative dc voltages, which have three interfaces, namely a positive output "+", a neutral output "0", and a negative output "-", wherein the positive output "+" and the neutral output "0" output the adjustable positive dc voltage, the negative output "-" and the neutral output "0" output the adjustable negative dc voltage, and the neutral output "0" outputs the neutral point potential, and is connected to the high frequency Pulse signal Pulse1 (shown in fig. 3). The positive direct current voltage value output by the positive output end "+" is V P The negative DC voltage value output by the negative output end is V N (V P ≠V N ) The amplitude ratio of the positive voltage and the negative voltage is V P /V N . Positive output terminal "+" (positive dc voltage V) of the high-voltage dc power supply 11 P ) Is connected with one end of a first energy storage capacitor 13 (C1), the other end of the first energy storage capacitor 13 is connected with one end of a second energy storage capacitor 12 (C2) and a neutral output end 0 of the high-voltage direct-current power supply 11, and a negative output end negative of the high-voltage direct-current power supply 11 (negative direct-current voltage V) N ) And the high-voltage direct-current power supply is connected with the other end of the second energy storage capacitor 12, and meanwhile, the input control end of the high-voltage direct-current power supply 11 is connected with the output control end of the control system circuit 19 through RS232 or RS485 communication, and the magnitude of the output positive and negative direct-current double-circuit voltage is controlled through RS232 or RS 485.
A second storage capacitor 12 (C2). One end of the second energy storage capacitor 12 is connected with the negative output end "-" of the high-voltage direct-current power supply 11, and the other end of the second energy storage capacitor 12 is connected with one end of the first energy storage capacitor 13 and the neutral output end "0" of the high-voltage direct-current power supply 11.
A first storage capacitor 13 (C1). One end of the first energy storage capacitor 13 is connected with the positive output end "+" of the high-voltage direct-current power supply 11, and the other end of the first energy storage capacitor 13 is connected with one end of the second energy storage capacitor 12 and the neutral output end "0" of the high-voltage direct-current power supply 11.
A high voltage discharge circuit 14. One end of the high-voltage discharge circuit 14 is connected with one end of the first energy storage capacitor 13, the other end of the high-voltage discharge circuit 14 is connected with the other end of the second energy storage capacitor 12, and a discharge input control end of the high-voltage discharge circuit 14 is connected with a discharge output control end of the control system circuit 19.
An asymmetric waveform pulse generating circuit 15. The pulse generating circuit 15 of the asymmetric waveform includes a driving circuit 151 and an inverter circuit 152; the first input end of the pulse generating circuit 15 of the asymmetrical waveform is connected with one end of the first energy storage capacitor 13 and the positive output end "+" of the high-voltage direct-current power supply 11, the second input end of the pulse generating circuit 15 of the asymmetrical waveform is connected with the other end of the second energy storage capacitor 12 and the negative output end "-" of the high-voltage direct-current power supply 11, the output end of the pulse generating circuit 15 of the asymmetrical waveform is connected with the switch matrix circuit 16, and the pulse voltage and the pulse current output by the pulse generating circuit 15 of the asymmetrical waveform are respectively connected with the voltage and current sampling unit of the control system circuit 19.
A switch matrix circuit 16. The input terminal of the switch matrix circuit 16 is connected to the output terminal of the pulse generating circuit 15 of the asymmetric waveform, the first output terminal OUT1 of the switch matrix circuit 16 is connected to the catheter 17, and the second output terminal OUT2 of the switch matrix circuit 16 is connected to the electrophysiological recorder 21.
A conduit 17. The conduit 17 is connected to the first output OUT1 of the switch matrix circuit 16. Meanwhile, the catheter has the functions of an ablation catheter and a mapping catheter.
An electrocardiograph signal detection circuit 18. The electrocardio signal detection circuit 18 is connected with the control system circuit 19, and sends a trigger signal of asymmetric pulse voltage output to the control system circuit 19.
And a control system circuit 19. The control system circuit 19 is connected with the high-voltage direct-current power supply 11 to control the output and the magnitude of the direct-current voltage of the high-voltage direct-current power supply 11, the control system circuit 19 is connected with the high-voltage discharging circuit 14 to control the high-voltage discharging circuit to discharge the energy stored by the first energy storage capacitor 13 and the second energy storage capacitor 12, the control system circuit 19 is connected with the pulse generating circuit 15 with an asymmetric waveform to control the output and the closing of the pulse voltage, the control system circuit 19 comprises a voltage current signal acquisition unit connected with the pulse generating circuit 15 with an asymmetric waveform to be used for acquiring pulse voltage and pulse current signals, the control system circuit 19 is connected with the electrocardiosignal detection circuit 18 to receive a trigger control signal sent by the electrocardiosignal detection circuit 18, the control system circuit 19 is connected with the foot switch 20 to control the output of the high-voltage pulse through detecting the signal of the foot switch 20. The control system circuit 19 may also comprise a temperature signal acquisition unit for acquisition of electrode temperature signals of the catheter 17.
A foot switch 20. The foot switch 20 is connected to the control system circuit 19 to control the output of the high voltage electric pulse.
An electrophysiological recorder 21. The electrophysiological recorder 21 is connected to the switch matrix circuit 16 for measuring the potential signals of the electrocardio before and after ablation.
As shown in fig. 2, a novel high-voltage discharge circuit of a high-frequency irreversible electroporation pulse ablation apparatus for treating atrial fibrillation comprises: a discharge input control terminal G, a discharge switch SW and a discharge resistor R.
One end of the high-voltage discharge circuit 14 is connected with one end of the first energy storage capacitor 13, the other end of the high-voltage discharge circuit 14 is connected with the other end of the second energy storage capacitor 12, and a discharge input control end of the high-voltage discharge circuit 14 is connected with a discharge output control end of the control system circuit 19. When the operation is stopped or the equipment fails, the control system circuit 19 immediately gives a discharging output control signal to the discharging input control terminal G, and the high-voltage discharging circuit 14 starts to operate to discharge the energy stored in the first energy storage capacitor 13 and the second energy storage capacitor 12.
The discharging switch SW is an Insulated Gate Bipolar Transistor (IGBT), one end (collector C) of the discharging switch SW is connected with the positive output end "+" of the high-voltage direct-current power supply 11, the other end (emitter E) of the discharging switch SW is connected with one end of the discharging resistor R, and the gate stage G of the discharging switch SW is connected with the discharging output control end of the control system circuit 19; the other end of the discharge resistor R is connected to the negative output terminal "-" of the high-voltage dc power supply 11.
As shown in fig. 3, a circuit diagram of a high-voltage dc power supply and an energy storage capacitor of a novel high-frequency irreversible electroporation pulse ablation device for treating atrial fibrillation comprises:
the high-voltage direct current power supply 11, the first energy storage capacitor C1 and the second energy storage capacitor C2, three interfaces of the high-voltage direct current power supply 11 are respectively a positive output end "+", a neutral output end "0" and a negative output end "-", wherein the positive output end "+" is connected with one end of the first energy storage capacitor C1, the neutral output end "0" is respectively connected with the other end of the first energy storage capacitor C1, one end of the second energy storage capacitor C2 and the high-frequency Pulse signal Pulse1, the negative output end "-" is connected with the other end of the second energy storage capacitor C2, and meanwhile, the input control end of the high-voltage direct current power supply 11 is in communication connection with the output control end of the control system circuit 19 through RS232 or RS485, and the size of positive and negative direct current double-circuit voltage output is controlled through RS232 or RS 485.
As shown in fig. 4, a novel asymmetric waveform pulse generating circuit 15 of a high-frequency irreversible electroporation pulse ablation apparatus for treating atrial fibrillation adopts a half-bridge inverter with a circuit diagram comprising:
one end (collector C) of the IGBT1 in the half-bridge converter is connected with a positive output end "+" of the high-voltage direct-current power supply 11, and the other end (emitter E) of the IGBT1 is connected with a high-frequency Pulse signal Pulse2 and one end (collector C) of the IGBT2 in the half-bridge converter; the other end (emitter E) of the IGBT2 is connected to a negative output terminal "-" of the high voltage dc power supply 11. The first driving end Driver1 of the half-bridge converter is connected with the gate G of the IGBT1, and the second driving end Driver2 of the half-bridge converter is connected with the gate G of the IGBT 2.
As shown in fig. 5, a novel high-frequency irreversible electroporation pulse ablation apparatus for treating atrial fibrillation outputs an asymmetric pulse waveform diagram, comprising:
positive pulse voltage 101, negative pulse voltage 102, positive pulse width 201, negative pulse width 202, inter-phase interval 203, pulse interval 204, pulse period length 205, and pulse train length 206, the amplitude of output positive pulse voltage 101 isV P The output negative pulse voltage 102 has a magnitude of V N The amplitude ratio of the output positive and negative pulse voltages is V P /V N 。
The foregoing describes in detail preferred embodiments of the present invention. It should be understood that numerous modifications and variations can be made in accordance with the concepts of the invention without requiring creative effort by one of ordinary skill in the art. Therefore, all technical solutions which can be obtained by logic analysis, reasoning or limited experiments based on the prior art by the person skilled in the art according to the inventive concept shall be within the scope of protection defined by the claims.
Claims (8)
1. The high-frequency irreversible electroporation pulse ablation device with the asymmetric waveform is characterized by comprising a high-voltage direct-current power supply, an energy storage capacitor module, a high-voltage discharge circuit, a pulse generation circuit with the asymmetric waveform, a switch matrix circuit, a catheter and a control system circuit; the control system circuit is connected with the high-voltage direct-current power supply, the energy storage capacitor module, the high-voltage discharge circuit, the pulse generating circuit of the asymmetric waveform and the switch matrix circuit; the high-voltage direct current power supply is configured to receive the control of the control system circuit and output adjustable positive and negative direct current double-circuit voltage; the energy storage capacitor module is connected with the output end of the high-voltage direct-current power supply in parallel; the high-voltage discharge circuit is connected with the energy storage capacitor module in parallel; the pulse generating circuit of the asymmetrical waveform is configured to output an asymmetrical high-frequency pulse signal through a half-bridge converter from the input positive and negative direct current two-way voltage; the asymmetric high-frequency pulse signal is connected to the catheter through the switch matrix circuit; the input control end of the high-voltage direct-current power supply is connected with the output control end of the control system circuit through RS232 or RS485 communication so as to control the output positive and negative direct-current double-circuit voltage; the high-voltage direct current power supply is provided with a positive output end, a negative output end and a neutral output end, the energy storage capacitor module comprises a first energy storage capacitor and a second energy storage capacitor, the positive output end of the high-voltage direct current power supply is connected with one end of the first energy storage capacitor, the other end of the first energy storage capacitor is connected with one end of the second energy storage capacitor and the neutral output end of the high-voltage direct current power supply, and the negative output end of the high-voltage direct current power supply is connected with the other end of the second energy storage capacitor.
2. The asymmetric waveform high frequency irreversible electroporation pulse ablation apparatus of claim 1, wherein one end of said high voltage discharge circuit is connected to one end of said first energy storage capacitor, the other end of said high voltage discharge circuit is connected to the other end of said second energy storage capacitor, and a discharge input control end of said high voltage discharge circuit is connected to a discharge output control end of said control system circuit.
3. The high frequency irreversible electroporation pulse ablation apparatus of claim 2, wherein the high voltage discharge circuit comprises a discharge switch and a discharge resistor connected in series, a control terminal of the discharge switch being a discharge input control terminal of the high voltage discharge circuit.
4. The high-frequency irreversible electroporation pulse ablation device of claim 3, wherein the discharge switch is an insulated gate bipolar transistor, a collector of the discharge switch is connected with a positive output end of the high-voltage direct current power supply, an emitter of the discharge switch is connected with one end of the discharge resistor, the other end of the discharge resistor is connected with a negative output end of the high-voltage direct current power supply, and a gate of the discharge switch is connected with a discharge output control end of the control system circuit as a control end.
5. The asymmetrical waveform high frequency irreversible electroporation pulse ablation apparatus of claim 1, wherein the asymmetrical waveform pulse generation circuit comprises a first switch and a second switch, the first switch and the second switch are insulated gate bipolar transistors, a collector of the first switch is connected with a positive output end of the high voltage direct current power supply, a neutral output end of the high voltage direct current power supply is used as a first output end of the asymmetrical high frequency pulse signal, an emitter of the first switch is connected with a collector of the second switch to be used as a second output end of the asymmetrical high frequency pulse signal, an emitter of the second switch is connected with a negative output end of the high voltage direct current power supply, and gates of the first switch and the second switch are respectively used as a first driving end and a second driving end of the asymmetrical waveform pulse generation circuit to be connected to the control system circuit.
6. The high-frequency irreversible electroporation pulse ablation apparatus of claim 1, wherein the control system circuit comprises a voltage-current signal acquisition unit for acquiring voltage and current signals of the asymmetric high-frequency pulse signals output by the pulse generation circuit of the asymmetric waveform and a temperature signal acquisition unit for acquiring electrode temperature signals of the catheter.
7. The high frequency irreversible electroporation pulse ablation apparatus of claim 1, further comprising an electrophysiological recorder coupled to the switch matrix circuit, the electrophysiological recorder for measuring electrical potential signals of the cardiac electrical prior to and after ablation.
8. The high frequency irreversible electroporation pulse ablation apparatus of claim 1, further comprising an electrocardiosignal detection circuit and a foot switch connected to the control system circuit, the electrocardiosignal detection circuit and foot switch for triggering/controlling the output of the asymmetric high frequency pulse signal.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111326236.0A CN114041873B (en) | 2021-11-10 | 2021-11-10 | High-frequency irreversible electroporation pulse ablation device with asymmetric waveform |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111326236.0A CN114041873B (en) | 2021-11-10 | 2021-11-10 | High-frequency irreversible electroporation pulse ablation device with asymmetric waveform |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN114041873A CN114041873A (en) | 2022-02-15 |
| CN114041873B true CN114041873B (en) | 2023-12-26 |
Family
ID=80207991
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202111326236.0A Active CN114041873B (en) | 2021-11-10 | 2021-11-10 | High-frequency irreversible electroporation pulse ablation device with asymmetric waveform |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN114041873B (en) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US12076071B2 (en) | 2020-08-14 | 2024-09-03 | Kardium Inc. | Systems and methods for treating tissue with pulsed field ablation |
| AU2022254861B2 (en) | 2021-04-07 | 2024-01-18 | Btl Medical Development A.S. | Pulsed field ablation device and method |
| CN113180818B (en) * | 2021-05-06 | 2024-03-15 | 上海玄宇医疗器械有限公司 | Device for high-voltage electric pulse ablation and electrophysiological recorder cooperative work |
| IL309432B1 (en) | 2021-07-06 | 2024-10-01 | Btl Medical Dev A S | Pulsed field ablation device and method |
| CN113481094A (en) * | 2021-07-09 | 2021-10-08 | 重庆大学 | HB-MMC-based asymmetric bipolar cell fusion instrument and control method |
| CN114601551B (en) * | 2022-03-18 | 2022-11-18 | 天津市鹰泰利安康医疗科技有限责任公司 | High-frequency irreversible electroporation treatment system |
| CN115005961B (en) * | 2022-07-07 | 2023-05-12 | 上海普实医疗器械股份有限公司 | Cardiac pulse electric field ablation system |
| WO2024075034A1 (en) | 2022-10-05 | 2024-04-11 | Btl Medical Technologies S.R.O. | Pulsed field ablation device and method |
| CN118285901B (en) * | 2024-04-25 | 2024-10-11 | 天津市鹰泰利安康医疗科技有限责任公司 | High-frequency bipolar unrecoverable electroporation circuit |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106877729A (en) * | 2017-03-24 | 2017-06-20 | 上海健康医学院 | A kind of irreversible electroporation apparatus of high frequency |
| WO2018010659A1 (en) * | 2016-07-12 | 2018-01-18 | 上海睿刀医疗科技有限公司 | Irreversible electroporation device and operation method therefor |
| CN112022331A (en) * | 2020-08-31 | 2020-12-04 | 天津市鹰泰利安康医疗科技有限责任公司 | Irreversible electroporation ablation system |
| CN113017822A (en) * | 2020-11-18 | 2021-06-25 | 上海玄宇医疗器械有限公司 | Power control system |
-
2021
- 2021-11-10 CN CN202111326236.0A patent/CN114041873B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2018010659A1 (en) * | 2016-07-12 | 2018-01-18 | 上海睿刀医疗科技有限公司 | Irreversible electroporation device and operation method therefor |
| CN106877729A (en) * | 2017-03-24 | 2017-06-20 | 上海健康医学院 | A kind of irreversible electroporation apparatus of high frequency |
| CN112022331A (en) * | 2020-08-31 | 2020-12-04 | 天津市鹰泰利安康医疗科技有限责任公司 | Irreversible electroporation ablation system |
| CN113017822A (en) * | 2020-11-18 | 2021-06-25 | 上海玄宇医疗器械有限公司 | Power control system |
Also Published As
| Publication number | Publication date |
|---|---|
| CN114041873A (en) | 2022-02-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN114041873B (en) | High-frequency irreversible electroporation pulse ablation device with asymmetric waveform | |
| US20230248412A1 (en) | Generating irreversible electroporation and radiofrequency-abaltion (ire/rfa) waveforms | |
| US12042208B2 (en) | Systems, devices, and methods for ablation using surgical clamps | |
| US10687892B2 (en) | Systems, apparatuses, and methods for delivery of pulsed electric field ablative energy to endocardial tissue | |
| US11135002B2 (en) | System and method for temperature enhanced irreversible electroporation | |
| CN113180818B (en) | Device for high-voltage electric pulse ablation and electrophysiological recorder cooperative work | |
| CN113017822A (en) | Power control system | |
| CN114587562B (en) | Closed-loop control system for pulse ablation | |
| EP4025130A1 (en) | Ablation assembly to treat target regions of tissue in organs | |
| CN106877729A (en) | A kind of irreversible electroporation apparatus of high frequency | |
| CN111419383B (en) | Combined pulse generation circuit and method applied to pulsed electric field ablation technology | |
| CN113143444A (en) | Cardiac pulse electric field ablation catheter device | |
| CN111437513B (en) | Multi-mode high-voltage ultrashort pulse electric field atrial fibrillation treatment electrode and treatment equipment | |
| CN112932648A (en) | Method for improving electroporation effect and preheating pulse ablation system | |
| CN115281822A (en) | Cardiac ablation pulse electric field control device, control method and operation method | |
| CN113633370A (en) | High-frequency composite electric field ablation system | |
| US20230218340A1 (en) | Ablation equipment to treat target regions of tissue in organs | |
| CN215018825U (en) | Preheating pulse ablation system for improving electroporation effect | |
| CN219271099U (en) | High-voltage pulse intracavity ablation system | |
| CN219271105U (en) | Electrocardiosignal acquisition system of pulse ablation equipment | |
| CN115670640A (en) | High-voltage electric pulse ablation and electrophysiological recorder cooperation device | |
| CN115024817A (en) | Control method of pulse ablation equipment with double MCU control systems | |
| CN216060719U (en) | Bipolar adjustable punctiform ablation catheter and equipment thereof | |
| CN115462894A (en) | Fast arrhythmic ablation system originated from his bundle adjacent myocardial tissue | |
| CN215228343U (en) | Pulsed electric field ablation device |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |