WO2021013152A1

WO2021013152A1 - Automatic film laminating machine for biosensor electrode

Info

Publication number: WO2021013152A1
Application number: PCT/CN2020/103320
Authority: WO
Inventors: 钱成
Original assignee: 苏州百孝医疗科技有限公司
Priority date: 2019-07-22
Filing date: 2020-07-21
Publication date: 2021-01-28
Also published as: CN110293021B; CN110293021A

Abstract

An automatic film laminating machine for a biosensor electrode, consisting of a bearing base (1), an automatic feeding system (2), a film laminating system (3), a power control system (4), a display and control system (5), an atmosphere monitoring system (6),and a workpiece monitoring system (7). Compared with the prior art, the automatic film laminating machine for the biosensor electrode and the automatic film laminating process improve the production efficiency, the film thickness and film laminating length consistency can be ensured, the film laminating quality is improved, volatilization of film liquid can be reduced, and the cost is reduced.

Description

Automatic film laminating machine for biosensor electrode

Cross references to related applications

This disclosure claims the priority of a Chinese patent application filed with the Chinese Patent Office on July 22, 2019, with the application number CN201910659541.8 and the title "A kind of automatic biosensor electrode laminating machine", the entire content of which is incorporated by reference In this disclosure.

Technical field

The present disclosure relates to an automatic coating device for sensor electrodes, in particular a coating device for capillary needle electrodes.

Background technique

At present, with the development of life sciences, biosensors have been widely used. Biosensors use biomolecules on the sensor electrodes to react with certain substances in the detected object to generate corresponding signals for analysis and utilization. Common biosensors usually use very thin metal wires or polymer sheets as carriers, and then coat biomolecules, polymers, etc. At present, the coating on the sensor electrode generally adopts an open manual coating or coating method, which causes a waste of solution, and cannot guarantee the consistency of the film thickness and the length of the coating, and the biosensor cannot achieve effective performance. In addition, some biomolecules and membrane liquids need to be coated in a specific atmosphere. Some biomolecules and membrane liquids are very volatile and need to be coated in a closed cavity. These specific biosensor electrode preparation conditions result in low production efficiency and high production costs.

Summary of the invention

The technical problem to be solved in the present disclosure is to provide a biosensor electrode automatic laminating machine in view of the above-mentioned shortcomings of the prior art.

In order to solve the above technical problems, the technical solutions adopted in this disclosure are:

A biosensor electrode automatic laminating machine includes a carrying base, an automatic feeding system and a laminating system; the carrying base includes a horizontal base plate, a frame and a main switch. The frame is mounted on the horizontal base plate, and the main switch is located in the machine. On the rack, the automatic feeding system, the laminating system, the power control system, and the display and control system are all set in the frame; the automatic feeding system includes a buffer zone, an x-axis module, and a gripper module, and an x-axis module The upper part is provided with a first optical axis that drives the movement of the clamping jaw module. The buffer zone is provided with a workbench, a workpiece placement rack, a workpiece switching module, a buffer atmosphere box and a buffer door, and the workbench is fixed on the workpiece switching module. The workpiece placement frame is placed on the workbench, the workpiece switching module can be moved in the Y-axis direction, and the buffer door can be closed to communicate with the laminating system; the laminating system is composed of a laminating power system and a membrane liquid box cover It consists of a power system and a closed working area. The film-coated power system includes an XZ axis module, a sealing sleeve and a second optical axis. The sealing sleeve is installed in the upper part of the working area. The second optical axis passes through the working area and the upper end of the second optical axis is connected. XZ axis module, the lower end is located in the working area. The working area is provided with a workpiece chuck, a membrane liquid box, a membrane liquid box cover and an atmosphere box. The membrane liquid box cover is closed on the membrane liquid box and the atmosphere box is located in the membrane liquid In the lower part of the box, the workpiece chuck is located at the top of the working area, and the workpiece chuck is connected to the second optical axis.

As a further preferred solution, the bottom of the horizontal base plate has foot pads, and the side of the rack has a fan.

As a further preferred solution, the clamping jaw module is divided into a clamping jaw tightening device and a clamping jaw, the clamping jaw is installed on the clamping jaw tightening device, and the first optical axis is fixedly connected to the clamping jaw tightening device; A sealing block is arranged outside the clamping jaw module, the first optical axis penetrates the sealing block, and the buffer zone and the sealing block are assembled into a closed area.

As a further preferred solution, the buffer zone also includes an upper first opening and closing door, a side second opening and closing door, and a lifting mechanism configured to control the buffer door. The upper part of the buffer zone is provided with a power configured to control the lifting mechanism. system.

As a further preferred solution, the laminating system further includes a laminating power system, a membrane liquid box cover power system and a third optical axis. The laminating power system is located above the rear side of the working area and is fixed on the membrane power system by installation. The third optical axis can make the workpiece chuck in the workpiece area move in the XZ axis direction; the membrane liquid box cover power system is located below the rear side of the working area, and the third optical axis fixed on the membrane liquid box cover power system can make The membrane liquid box cover realizes the opening and closing in the Y-axis direction.

As a further preferred solution, the working area further includes a third opening and closing door and a window.

As a further preferred solution, it also includes a display and control system, an atmosphere monitoring system, and a workpiece monitoring system; the display and control system includes a display, a button, and an emergency stop switch; the atmosphere monitoring system includes a display controller and a gas concentration sensor, The gas concentration sensor is located in the work area; the workpiece monitoring system includes an opening and closing door sensor, a placement rack sensor, a workpiece position sensor, a workpiece switching module sensor, and a buffer door sensor. The opening and closing door sensor is located at the first opening and closing door and placed The rack sensor is located on the workbench, the workpiece position sensor is located on the upper right side of the workpiece placement rack, and is installed and fixed on the door panel on the right side of the buffer zone. The workpiece switching module sensor is located at the bottom right of the workpiece switching module, and installed on the door panel on the right side of the buffer zone. Above, the buffer door sensor is located at the buffer door.

Compared with the prior art, the biosensor electrode automatic laminating machine of the present disclosure, compared with the open manual laminating or coating method, not only improves the production efficiency, but also can ensure the thickness and length of the film. Consistency, improve the quality of the film. In addition, multiple closed work and buffer zones can effectively prevent the volatilization of the solution in the cavity (especially some of the solution is very expensive), maintain a relatively reliable atmosphere, further improve the production efficiency, and reduce the volatilization of the solution. cost.

Description of the drawings

Figure 1 is a front view of the disclosure;

Figure 2 is a schematic diagram of the structure of the automatic feeding system;

Figure 3 is a schematic diagram of the structure of the film coating system;

Figure 4 is a top view of the disclosure;

Figure 5 is a left side view of the present disclosure.

Detailed ways

The preferred technical solutions of the present disclosure will be described in detail below with reference to the accompanying drawings.

A biosensor electrode automatic laminating machine is composed of a supporting base 1, an automatic feeding system 2, a laminating system 3, a power control system 4, a display and control system 5, an atmosphere monitoring system 6, and a workpiece monitoring system 7.

The supporting base 1 includes a horizontal base plate 100, a foot pad 110, a frame 120, a fan 130, and a main switch 140. Among them, the integrated frame 120 is fixedly connected with the horizontal substrate 100 with screws, and the horizontal substrate ensures the structural stability and movement accuracy of the automatic feeding system 2 and the film coating system 6. There are 6 adjustable foot pads 110 at the bottom of the horizontal base plate 100, and the level can be adjusted according to the site. After the fan 130 is turned on, the working temperature of the internal parts of the device can be reduced. The main switch 140 is connected to the main power source, and can switch the device power source.

The automatic feeding system 2 is composed of a buffer area 200, an x-axis module 210, and a gripper module 220. The clamping jaw module 220 and the optical axis 211 of the x-axis module are fixedly connected by screws. The buffer area 200 and the sealing block 230 are assembled to form a sealed area. Driven by the x-axis module 210, the jaw module 220 can move in the x-axis direction in the sealed area.

The clamping jaw module 220 includes a clamping jaw tightening device 221 and a clamping jaw 222. When the clamping jaw module 220 moves at a predetermined position, the tightening device 221 will be activated so that the clamping jaw 222 can hold the workpiece and carry the workpiece along. Move in the x-axis direction.

Buffer 200, including opening and closing door 201, opening and closing door 202, buffer door 203, workpiece placement rack 204, workpiece switching module 205 and buffer atmosphere box 206, lowering mechanism 207, power system 208 of the lifting mechanism, and workbench 209 . The door 201 is opened and closed and the handle is pulled open by the upper part, and is configured to pick and place the workpiece. The opening and closing door 202 can be opened by unscrewing two screws, and is configured to take in and place the atmosphere box 206 and replace the solution therein.

The buffer door 203 is located between the buffer 200 and the working area 300. The opening and closing of the buffer door is realized by the lifting mechanism 207 located inside the buffer zone. The power system 208 of the lifting mechanism is located outside the buffer zone. The lifting mechanism is driven by the synchronous belt and the electrode.

The workpiece placement rack 204 is configured to place the workpiece 8. After the workpiece is installed externally, the employee can put it into the buffer workbench 209 together with the workpiece placement rack 204. The workpiece can only be moved from the left side in the placing frame, that is, move to the working area 300 under the action of the clamping jaw 222.

The working table 209 is located on the workpiece switching module 205 and is fixed with screws. Two workpiece placement racks 204 can be placed on the workbench 209, one placement rack is used to place the workpiece to be coated, and the other empty placement rack is used to recover the workpiece that has been coated. The workpiece switching module 205 can move in the Y-axis direction. Make the placing rack 204 face the work position (at this time, the workpiece can enter the work area or return from the work area to the placing rack).

The buffer atmosphere box 206 maintains the atmosphere in the buffer zone after the solution stored therein volatilizes. There is a buffer door between the work area and the buffer zone. When the workpiece passes by, the buffer door will temporarily open. At this time, the atmosphere of the work zone and the buffer zone are equal, so the atmosphere of the work zone changes little.

The membrane covering system 3 is composed of a working area 300, a membrane covering power system 310, and a membrane liquid box cover power system 320. The film-coated power system 310 and the film-liquid box cover power system 320 are both located outside the working area 300, and are connected to the internal mechanism of the working area through the optical axis 311 and the optical axis 321, respectively, to provide power for the inside.

The coated power system 310 is composed of an XZ axis module 313, a sealing sleeve 312, and an optical axis 311. The XZ axis module 313 and the frame 120 are fixed by screws to ensure structural stability and movement accuracy. Driven by the XZ axis module, the workpiece 8 in the work area can move in the X axis and Z axis directions. So as to realize the workpiece transportation and electrode coating action.

The sealing sleeve 312 is configured to connect the optical axis 311 and the working area 300. The sealing sleeve 312 is made of a soft material, such as silica gel. When the optical axis 311 is moved horizontally under the action of the XZ axis module 313, the sealing sleeve 312 can provide enough deformation to keep the working area sealed.

The working area 300 includes an opening and closing door 301, a window 302, a workpiece chuck 303, a membrane liquid box 304, a membrane liquid box cover 305 and an atmosphere box 306. The opening and closing door 301 can be opened by unscrewing a screw in the middle, and is configured to take in the membrane liquid box 304 and the atmosphere box 306, and replace the solution therein. The material of the window 302 is a transparent visible material, preferably glass or acrylic, and the internal working state can be seen through the window 302.

The workpiece chuck 303 is configured to clamp and fix the workpiece. The clamping jaw 222 carries the workpiece into the work area and pushes the workpiece into the chuck 303. The chuck 303 and the optical axis 311 are driven by the optical axis through screw parts to realize the workpiece transportation and the electrode coating action.

The membrane liquid box 304 is placed on the atmosphere box 306 and connected with the atmosphere box by pins. Therefore, it can be taken and placed together with the atmosphere box or separately. The film liquid box 304 contains the film liquid used for film coating. The upper part is covered with a membrane liquid box cover 305.

The membrane liquid box cover 305 is connected with the membrane liquid box cover power system 320 through the optical axis 321. When the workpiece is lowered to cover the film, the cover of the film liquid box will be automatically opened under the control of the control system 4. When the work piece is coated with a certain distance away from the membrane liquid box, the lid of the membrane liquid box will automatically close to reduce the volatilization of the membrane liquid.

In the atmosphere box 306, the stored solution will maintain the atmosphere in the working area after volatilization. When the membrane liquid box cover 305 is opened, the atmosphere in the working area can further reduce the volatilization of the membrane liquid.

The power control system 4, through computer programming control, can realize the automatic switching position of the placement frame 204 on the worktable 209, realize the automatic fetching and feeding of the gripper 222, realize the automatic opening and closing of the buffer door 203, and realize the working area chuck 303x The workpiece is transported in the axial direction, and the membrane liquid box cover 305 can be automatically opened and closed, and the chuck can automatically lift the coating film with the workpiece, and by changing the lowering height and speed, different film lengths and film thicknesses can be realized.

The display and control system 5 includes a display 501, a button 502, and an emergency stop switch 503. The display 501 can display the electrode coating height and the lifting speed, can display the current operating state of the equipment and the coating steps, can display the current set parameters of the equipment, and so on. The button 502 can start and stop the coating process, can adjust equipment parameters, and can switch to manual mode for coating. The emergency stop switch 503 can quickly turn off the equipment in the event of a failure or problem. So as to protect the workpiece and equipment from damage.

The atmosphere monitoring system 6 mainly includes a gas concentration sensor 601 and a display controller 600. The gas concentration sensor 601 is installed inside the working area and is configured to monitor the concentration of gas volatilized from the solution in the atmosphere box 306, that is, the above-mentioned working area atmosphere. The gas concentration sensor 601 is externally connected to the display controller 600 and the power control system 4. The display controller 600 can display the gas concentration monitored in the current working area. The atmosphere range can also be set. When the atmosphere in the work area exceeds the set value, the power system will stop the movement of the workpiece until the atmosphere in the work area returns to the set value.

The workpiece monitoring system 7 includes an opening and closing door sensor 700, a shelf sensor 710, a workpiece position sensor 720, a workpiece switching module sensor 730, and a buffer door sensor 740.

The opening and closing door sensor 700 can detect the state of the opening and closing door 201. When the opening and closing door 201 is opened, the power control system 4 will stop the movement of the workpiece in the buffer zone, and the work area will not be affected. Prevent employees from reaching into the buffer zone when working in the buffer zone, which may cause danger.

The shelf sensor 710 can detect the shelf placement status. If the shelf is not installed or the shelf is placed incorrectly, the system will not continue to work even after the employee presses the start button. It can effectively place the danger caused by missing or wrong installation.

The workpiece position sensor 720 is a proximity sensor. It can detect the position of the workpiece on the placement rack. When the sensor corresponding to the placement frame of the workpiece to be coated is detected, the gripper 222 will grip the workpiece and send the workpiece into the chuck 303 in the working area. When the sensor corresponding to the placement rack for recycling the workpiece does not detect it, that is, when there is no workpiece on the placement rack, the gripper 222 will enter the working area and take the laminated workpiece back to the placement rack. In the above process, the work position of the placement rack is detected by the workpiece switching module sensor 730, and the positions of the two placement racks are correspondingly switched to realize the cycle operation.

The buffer door sensor 740 can detect the opening/closing state of the buffer door 203, and only opens when the workpiece needs to pass.

When in use, load the workpiece 8 into one of the placing racks 204 outside the equipment; open the opening and closing door 201, at this time the opening and closing door sensor 700 detects that the opening and closing door is open, and the power control system 4 will stop all movement of the buffer zone ; Put the two placing racks 204 (one with the workpiece 8 and one empty) together on the working table 209 of the buffer zone. At this time, the shelf sensor 710 can detect the state of the shelf. When the opening and closing door 201 is closed and the 502 button is pressed, the equipment starts to automatically overwrite the mold.

The workpiece position sensor 720 first detects the position of the workpiece on the placement rack. If the conditions are met, the workpiece switching mold will move the placement rack to be coated to the work position. At this time, the clamping jaw 222 will move in the X-axis direction and clamp the workpiece. And move the workpiece to the work area. At the same time, the XZ axis module 313 will move towards the slow door. When both of them approach the buffer door, the buffer door 203 will open, so that the gripper 222 can feed the workpiece into the chuck 303 in the work area.

Then the clamping jaw 222 retreats to the buffer zone, and the buffer door is closed. At this time, the atmosphere monitoring system 6 will monitor the internal atmosphere of the working area. If it is within the set value range, the XZ-axis module 313 will first move to the X-axis away from the buffer door to transport the workpiece to the specified position of the film. Then the XZ axis module 313 will descend at the set variable speed. When descending to a specified height, the membrane liquid box cover 305 will automatically open. The workpiece continues to descend, and the electrode enters the membrane liquid of the membrane liquid box 304. After a period of time, the XZ axis module 313 will rise at a set variable speed. And transport the workpiece to the buffer door attachment.

At this time, the workpiece position sensor 720 will first detect the position of the workpiece on the placement rack. If the conditions are met, the recovered placement rack will be moved to the work position by the workpiece switching die. The buffer door 203 is opened, and the clamping jaw 222 takes the work piece that has been covered with the film back to the placing rack and returns to the origin. The buffer door is closed. At this time, the display 501 will show that the laminating has been completed, prompting the staff to take out the work piece that has been laminating, and the system will suspend work.

When the employee takes out the placement rack that has been covered with the film and puts the empty placement rack back, the display 501 will prompt for the next filming operation.

Among them, when the workpiece is laminating in the work area, the shelf to be coated in the buffer area (empty at this time, the workpiece is sent to the work area) can be taken out, and after the new workpiece is placed in the buffer area again On the workbench 209.

Furthermore, a biosensor electrode automatic coating device of the present disclosure is provided with a triple-layer enclosed space to reduce the volatilization of the membrane liquid. The coating process is carried out by a programmable computer controller to control the motor, and the electrode needle can be controlled as required The speed of the film controls the thickness of the film, and the depth of the motor feed is controlled to control the length of the film, which can be programmed and controlled according to different needs.

In the triple closed space, the first layer: the upper part of the membrane box is provided with a membrane box cover that can be automatically opened and closed. When the electrode is to be covered, the lid of the membrane liquid box is automatically opened by the motor, and when the membrane is completed, the lid of the membrane liquid box is automatically closed. Therefore, the volatilization of the membrane liquid can be prevented to the maximum extent.

In the triple confined space, the second layer: the working area is an openable confined space, and an atmosphere box is placed in the working area to maintain the atmosphere of the working area during the film coating process, thereby reducing the volatilization of the film liquid.

The triple confined space, the third layer: a buffer zone is set between the working area and the outside of the equipment, and an atmosphere box 206 is placed in the buffer zone. The solution stored in the atmosphere box is the same as that in the working area. Maintain the atmosphere in the buffer zone. There is a buffer door between the working area and the buffer zone. When the workpiece passes by, the buffer door will temporarily open. At this time, the atmosphere of the working area and the buffer zone are equal, so the atmosphere of the working area changes little.

The specific embodiments described above further describe the purpose, technical solutions and beneficial effects of the present disclosure in further detail. It should be understood that the above are only specific embodiments of the present disclosure and are not intended to limit the present disclosure. Any modification, equivalent replacement, improvement, etc., made within the spirit and principle of the present disclosure should be included in the protection scope of the present disclosure.

Claims

A biosensor electrode automatic laminating machine, which is characterized in that it comprises a carrying base (1), an automatic feeding system (2) and a laminating system (3); the carrying base (1) includes a horizontal substrate (100) , The frame (120) and the main switch (140), the frame (120) is installed on the horizontal base plate (100), the main switch (140) is located on the frame (120), the automatic feeding system (2), covering The membrane system (3), the power control system (4) and the display and control system (5) are all set in the frame (120); the automatic feeding system (2) includes a buffer zone (200), an x-axis module ( 210) and the clamping jaw module (220), the upper part of the x-axis module (210) is provided with a first optical axis (211) that drives the movement of the clamping jaw module (220), and a workbench ( 209), workpiece placement rack (204), workpiece switching module (205), buffer atmosphere box (206) and buffer door (203), the workbench (209) is fixed on the workpiece switching module (205), the workpiece The placement frame (204) is placed on the workbench (209), the workpiece switching module (205) can move in the Y-axis direction, the buffer door (203) can be closed and connected to the film coating system (3); The membrane system (3) is composed of a membrane power system (310), a membrane liquid box cover power system (320) and a closed working area (300). The membrane power system (310) includes an XZ axis module (313) and a sealed The sleeve (312) and the second optical axis (311), the sealing sleeve (312) is installed on the upper part of the working area (300), the second optical axis (311) passes through the working area (300), and the upper end of the second optical axis (311) Connected to the XZ axis module (313), the lower end is located in the working area (300), the working area (300) is provided with a workpiece chuck (303), membrane liquid box (304), membrane liquid box cover (305) and Atmosphere box (306), membrane liquid box cover (305) is covered with membrane liquid box (304), atmosphere box (306) is located at the lower part of membrane liquid box (304), and the workpiece chuck (303) is located in the working area (300) At the top, the workpiece chuck (303) is connected to the second optical axis (311).
A biosensor electrode automatic laminating machine according to claim 1, characterized in that: the bottom of the horizontal substrate (100) has a foot pad (110), and the side of the frame (120) has a fan (130) .
The automatic biosensor electrode laminating machine according to claim 1, wherein the clamping jaw module (220) is divided into a clamping jaw tightening device (221) and a clamping jaw (222). The clamping jaw (222) ) Is installed on the clamping jaw tightening device (221), the first optical axis (211) is fixedly connected to the clamping jaw tightening device (221); the clamping jaw module (220) is provided with a sealing block (230) , The first optical axis (211) penetrates the sealing block (230), and the buffer zone (200) and the sealing block (230) are assembled into a closed area.
A biosensor electrode automatic laminating machine according to claim 3, characterized in that: the buffer zone (200) further comprises an upper first opening and closing door (201) and a side second opening and closing door ( 202) and a lifting mechanism (207) configured to control the buffer door (203), and a power system (208) configured to control the lifting mechanism (207) is provided on the upper part of the buffer zone (200).
A biosensor electrode automatic laminating machine according to claim 4, characterized in that: the laminating system (3) further comprises a laminating power system (310), a membrane liquid box cover power system (320) and a The three optical axis (321), the film power system (310) is located above the rear side of the working area (300), and the third optical axis (321) fixed on the film power system (310) can make the work area The workpiece chuck moves in the XZ axis direction; the membrane liquid box cover power system (320) is located below the rear side of the working area, and the third optical axis (321) fixed on the membrane liquid box cover power system (320) can make the membrane liquid The box cover (305) realizes opening and closing in the Y-axis direction.
A biosensor electrode automatic laminating machine according to claim 5, wherein the working area (300) further comprises a third opening and closing door (301) and a window (302).
A biosensor electrode automatic laminating machine according to claim 5, characterized in that it also includes a display and control system (5), an atmosphere monitoring system (6) and a workpiece monitoring system (7); the display and control system The system (5) includes a display (501), a button (502) and an emergency stop switch (503); the atmosphere monitoring system (6) includes a display controller (600) and a gas concentration sensor (601), a gas concentration sensor (601) ) Is located in the working area (300); the workpiece monitoring system (7) includes an opening and closing door sensor (700), a shelf sensor (710), a workpiece position sensor (720), a workpiece switching module sensor (730) and a buffer The door sensor (740), the opening and closing door sensor (700) is located at the first opening and closing door (201), the placement rack sensor (710) is located at the workbench (209), and the workpiece position sensor (720) is located at the workpiece placement rack (204) ) The upper right side is installed and fixed on the door panel on the right side of the buffer zone (200), and the workpiece switching module sensor (730) is located at the lower right of the workpiece switching module (205), and installed and fixed on the door panel on the right side of the buffer zone (200) , The buffer door sensor (740) is located at the buffer door (203).