WO2021008588A9 - 一类嘧啶喹啉衍生物及其制备方法和应用 - Google Patents

一类嘧啶喹啉衍生物及其制备方法和应用 Download PDF

Info

Publication number
WO2021008588A9
WO2021008588A9 PCT/CN2020/102462 CN2020102462W WO2021008588A9 WO 2021008588 A9 WO2021008588 A9 WO 2021008588A9 CN 2020102462 W CN2020102462 W CN 2020102462W WO 2021008588 A9 WO2021008588 A9 WO 2021008588A9
Authority
WO
WIPO (PCT)
Prior art keywords
substituted
compounds
application
quinoline derivatives
class
Prior art date
Application number
PCT/CN2020/102462
Other languages
English (en)
French (fr)
Other versions
WO2021008588A1 (zh
Inventor
陈新滋
黄沃林
Original Assignee
广州新民培林医药科技有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 广州新民培林医药科技有限公司 filed Critical 广州新民培林医药科技有限公司
Publication of WO2021008588A1 publication Critical patent/WO2021008588A1/zh
Publication of WO2021008588A9 publication Critical patent/WO2021008588A9/zh

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

本发明公开了一类嘧啶喹啉衍生物包括前药及其制备方法和应用。所述嘧啶喹啉衍生物的结构如式(I)所示；其中，R 1为氢、C 1～4烷基、C 1～4卤代烷基、C4～7杂环芳基、C4～7取代杂环芳基、苄基或取代苄基、糖基、氨基酸；R 2、R 3、R 4和R 5各自独立地为氢、C 1～4烷基、C 1～4烷氧基、羟基、氨基或取代氨基、C 1～4卤代烷基或卤素、糖基、氨基酸；R 6为取代或非取代五元杂环、取代或非取代六元杂环、取代或非取代的C 8～12稠和杂环。本发明化合物对于5种癌细胞具有很好的抑制作用，大部分化合物的抑制IC 50值低于20μM；部分化合物的IC 50值甚至低于5μM，抑制作用极为显著，可制备成为抗癌药物进行应用。
PCT/CN2020/102462 2019-07-16 2020-07-16 一类嘧啶喹啉衍生物及其制备方法和应用 WO2021008588A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201910641563.1 2019-07-16
CN201910641563.1A CN110240590A (zh) 2019-07-16 2019-07-16 一类嘧啶喹啉衍生物及其制备方法和应用

Publications (2)

Publication Number Publication Date
WO2021008588A1 WO2021008588A1 (zh) 2021-01-21
WO2021008588A9 true WO2021008588A9 (zh) 2021-03-18

Family

ID=67892502

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CN2020/102462 WO2021008588A1 (zh) 2019-07-16 2020-07-16 一类嘧啶喹啉衍生物及其制备方法和应用

Country Status (2)

Country Link
CN (1) CN110240590A (zh)
WO (1) WO2021008588A1 (zh)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110240590A (zh) * 2019-07-16 2019-09-17 广州新民培林医药科技有限公司 一类嘧啶喹啉衍生物及其制备方法和应用
CN112062758A (zh) * 2020-08-28 2020-12-11 广州新民培林医药科技有限公司 一种硒酚喹啉衍生物及其制备方法和应用
CN113501783B (zh) * 2021-06-30 2022-11-15 上海应用技术大学 一种毛兰素杂环衍生物及其制备方法与应用
CN113387884A (zh) * 2021-07-05 2021-09-14 艾美科健（中国）生物医药有限公司 一种孟鲁司特钠杂质h的制备方法
CN114409590B (zh) * 2021-12-28 2023-08-01 河南新中飞科技有限公司 一种具有二氢吡啶腈结构的化合物及其制备方法和应用
CN114380741B (zh) * 2022-01-11 2023-03-24 济南大学 一种2-甲基喹啉类化合物的4号位烷基化衍生物的制备方法
CN114409710B (zh) * 2022-01-19 2024-01-09 西藏大学 Nir-ii多吡啶钌配合物及其制备方法和应用
CN115093369B (zh) * 2022-07-12 2024-05-10 浙大城市学院 一种3,4-二氢异喹啉-1-酮类化合物的合成方法
CN116217475A (zh) * 2023-02-21 2023-06-06 中国医学科学院阜外医院深圳医院(深圳市孙逸仙心血管医院) 一种多取代喹啉类衍生物的制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2474865T3 (es) * 2006-06-22 2014-07-09 Prana Biotechnology Limited Método de tratamiento de un tumor cerebral glioma
EP2994142A4 (en) * 2013-05-08 2017-03-29 Colorado Seminary, Which Owns and Operates The University of Denver Antibiotic and anti-parasitic agents that modulate class ii fructose 1,6-bisphosphate aldolase
HUP1600234A2 (en) * 2016-04-05 2017-12-28 Mta Termeszettudomanyi Kutatokoezpont Mdr-reversing 8-hydroxy-quinoline derivatives
KR102002446B1 (ko) * 2017-03-16 2019-07-22 재단법인 대구경북첨단의료산업진흥재단 TGase 2 억제제로서의 퀴놀린-5,8-디온 유도체 및 이를 포함하는 약제학적 조성물
CN110240590A (zh) * 2019-07-16 2019-09-17 广州新民培林医药科技有限公司 一类嘧啶喹啉衍生物及其制备方法和应用

Also Published As

Publication number Publication date
CN110240590A (zh) 2019-09-17
WO2021008588A1 (zh) 2021-01-21

Similar Documents

Publication Publication Date Title
WO2021008588A9 (zh) 一类嘧啶喹啉衍生物及其制备方法和应用
RU2395507C2 (ru) Пиримидиновые производные
Cao et al. Synthesis and antiproliferative activity of 4-substituted-piperazine-1-carbodithioate derivatives of 2, 4-diaminoquinazoline
NO20083868L (no) IAP BIR domenebindende forbindelser
HUP0302891A2 (hu) PDE4 izoenzimek inhibitoraiként alkalmazható éterszármazékok, alkalmazásuk és ezeket tartalmazó gyógyszerkészítmények
Carta et al. New chemotypes acting as isozyme-selective carbonic anhydrase inhibitors with low affinity for the offtarget cytosolic isoform II
NO20073956L (no) Pyrazolderivater for inhibering av CDK og GSK
NO20074311L (no) Kinazolinderivat med tyrosinkinase-inhiberendeaktivitet
WO2009050352A3 (fr) Derives d'imidazolones, procede de preparation et applications biologiques
NO20065327L (no) Fremgangsmate for fremstilling av derivarer av 5-'4-(2-hydroksy-propyl)-3,5-dihydro-3H'1, 2,4(triazin-2-yl)-benzamid.
CA2553328A1 (en) Pyridinium and quinolinium derivatives
EA200701780A1 (ru) Противоопухолевое средство
NO20063865L (no) Heterocyklisk substituerte 7-amino-4-kinolon-3-karboksylsyrederivater, fremgangsmate for fremstilling derav og deres anvendelse som medikamenter
EA202192900A1 (ru) Модуляторы пути интегрированной реакции на стресс
US20170334842A1 (en) Inhibitors of the mitf molecular pathway
WO2021012049A8 (en) Substituted 2-morpholinopyridine derivatives as atr kinase inhibitors
KR20170036745A (ko) 크산틴옥시다아제 저해약
CA3124838A1 (en) Methods and formulations to treat mitochondrial dysfunction
HUP0402500A2 (hu) Gyulladáskeltő citokinok kibocsátását gátló heterokondenzált pirazol-3-on vegyületek és az ezeket tartalmazó gyógyszerkészítmények
NO20055167L (no) Nye benzotiadiazinforbindelser, fremgangsmate for deres fremstilling og farmasoytiske sammensetninger inneholdende dem
NO20063111L (no) Fremgangsmate for fremstilling av tiazolpyrimidiner
Bairam et al. Synthesis, characterization, biological evaluation and docking of some novel substituted 1, 3-thiazine derivatives
NZ595890A (en) Pyrazole compound
WO2010082212A3 (en) N-biphenylacyl thiazolidine-2,4-dione derivatives, their synthesis and uses
Scala et al. Aldol-type compounds from water-soluble indole-3, 4-diones: synthesis, kinetics, and antiviral properties

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 20840065

Country of ref document: EP

Kind code of ref document: A1

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 20840065

Country of ref document: EP

Kind code of ref document: A1

122 Ep: pct application non-entry in european phase

Ref document number: 20840065

Country of ref document: EP

Kind code of ref document: A1