WO2021006507A1 - Procédé de préparation de poudre de composition pour lavage féminin contenant de la propolis et un extrait naturel - Google Patents

Procédé de préparation de poudre de composition pour lavage féminin contenant de la propolis et un extrait naturel Download PDF

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WO2021006507A1
WO2021006507A1 PCT/KR2020/008349 KR2020008349W WO2021006507A1 WO 2021006507 A1 WO2021006507 A1 WO 2021006507A1 KR 2020008349 W KR2020008349 W KR 2020008349W WO 2021006507 A1 WO2021006507 A1 WO 2021006507A1
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extract
powder
composition powder
weight
composition
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김주희
류충호
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(주)인벤티지랩
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
    • A61K8/987—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of species other than mammals or birds
    • A61K8/988—Honey; Royal jelly, Propolis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/0216—Solid or semisolid forms
    • A61K8/022—Powders; Compacted Powders
    • A61K8/0225—Granulated powders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/23—Sulfur; Selenium; Tellurium; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
    • A61K8/4946—Imidazoles or their condensed derivatives, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A61K8/65—Collagen; Gelatin; Keratin; Derivatives or degradation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67—Vitamins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67—Vitamins
    • A61K8/673—Vitamin B group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67—Vitamins
    • A61K8/676—Ascorbic acid, i.e. vitamin C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9771—Ginkgophyta, e.g. Ginkgoaceae [Ginkgo family]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9789—Magnoliopsida [dicotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9794—Liliopsida [monocotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/10—Washing or bathing preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/41—Particular ingredients further characterized by their size
    • A61K2800/412—Microsized, i.e. having sizes between 0.1 and 100 microns
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/59—Mixtures
    • A61K2800/592—Mixtures of compounds complementing their respective functions
    • A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18

Definitions

  • the present invention relates to a method for preparing a powder composition for feminine cleansers comprising propolis and natural extracts. More specifically, it relates to a method for producing a powder composition for a female cleanser for the prevention or treatment of diseases related to the vagina, including propolis and natural extracts, and water-soluble legal sulfur as a main component.
  • Sexual genitourinary system diseases include ovarian cancer, fibroids, posterior uterus, uterine and vaginal prolapse, uterine cancer, choriocarcinoma, cervical dysplasia, cervical cancer, vulvar vaginitis, vaginal mycosis, bacterial vaginosis, and sexually transmitted diseases. These diseases are relatively common. It has been reported that most women experience at least one disease during their lifetime.
  • lactic acid bacillus that maintains the genitourinary system pH at a weak acidity of 4.5 to 6.5 exists to prevent the propagation of harmful bacteria, but in addition to physical damage, stress and hormonal imbalance, the environment of the urogenital tableware system is not clean.
  • Female genitourinary system-related diseases are likely to occur due to bacterial diseases or sexually transmitted diseases.
  • active ingredients added to feminine cleansers are mostly chemically synthesized substances, and active substances derived from natural substances are mostly simple solvent extractions that extract specific ingredients using ethanol or other organic solvents. In that it can be applied to, there is a problem that the use of chemical synthetic substances or the use of simple organic solvent extraction components may give a feeling of rejection or irritation.
  • parabens and synthetic surfactants have been widely used as synthetic antimicrobial or preservatives, but the group of compounds called parahydroxybenzoic acid esters used under the common name'paraben' is somewhat different depending on the compound, but the human body It is widely used as a preservative or preservative for foods and cosmetics because it inhibits the growth of bacteria, yeast, and fungi at a concentration that is almost harmless, but recently it causes skin diseases, central nerve palsy, and cancer, and is reported as a hormone disturbing substance.
  • paraoxybenzoic acid ester methylparaben
  • SDS sodium lauryl sulfate
  • Korean Patent Laid-Open No. 10-2005-0118819 (published on December 20, 2005) describes casualties 1-20% by weight, phalanx skin 1-20%, angelica 1-20%, licorice 1-20%, peony 1- It is proposed a detergent composition mixed in a ratio of 20% by weight, 1 to 20% by weight of cheonggung, 1 to 20% by weight of white paper, 1 to 20% by weight of dry paper, 1 to 20% by weight of yellow white, and 1 to 20% by weight of mint, but chemical As a synthetic surfactant, sodium lauryl sulfate (SDS), which is known to have irritation and a risk of ulcers and atopy, is used as a feminine cleansing agent, and similarly, fermented extracts of the above plants are also used. no.
  • SDS sodium lauryl sulfate
  • Korean Patent No. 10-1345709 (registered on December 20, 2013) is an antimicrobial composition having antibacterial and antifungal effects including natural herbal extracts, wherein the natural herbal extracts are based on weight ratio of Gosam 1.0 to 4.0: Dansam 20 ⁇ 40: Casualties 1.0 ⁇ 4.0: Jibuja 1.0 ⁇ 4.0: Golden 40 ⁇ 60: Yellow lotus 5.0 ⁇ 15: Hwangbaek 1.0 ⁇ 4.0 A mixed natural herbal medicine was extracted using an extraction solvent, based on the total weight of the antibacterial composition 70 A naturally extracted antimicrobial composition for preventing and treating vaginitis having antibacterial activity on the fungus Candida albicans and the common bacteria Gardnerella Vaginalis contained in ⁇ 100% by weight, and a female cleansing agent containing the same Although disclosed, only the number of the aforesaid omitted material or a simple extract of another organic solvent is used, but the fermented product is not used.
  • Korean Patent Registration No. 10-1055079 (registered on Aug. 1, 2011) is a first step of preparing a fermented extract of chrysanthemum leaves, ginkgo leaves, sambaekcho, and pine needles and preparing a grapefruit seed extract; A second step of screening the antibacterial activity of the fermented extract and the extract by the paper disk method; A third step of determining the minimum growth inhibiting concentration of the fermentation extract and the extract by liquid medium dilution method; A fourth step of determining the mixing ratio of the fermentation extract and the extract according to the cell count method; characterized in that it comprises, and the fermentation extract of natural plants such as ginkgo leaves, chrysanthemum leaves, cedar leaves, pine needles, grapefruit seeds, etc.
  • Disclosed is an eco-friendly hand sanitizer that is harmless to the human body and has an environmentally friendly effect using a sterilizing effect, and a method for manufacturing the same, and the above-described conventional technology uses a fermented extract of chrysanthemum leaves and triticale vinegar, but plant extract: There is only mention that it is fermented by mixing in a ratio of brown sugar::malt 40:20:1, but there is no mention of which strain is used for fermentation.
  • Korean Registered Patent No. 10-1451730 (registered on October 10, 2014) has 10 to 20% by weight of Hwangbaek tree extract, 15 to 25% by weight of Gwirung tree extract, 10 to 20% by weight of Sambaekcho extract, 5 to 20% by weight of chinensis extract.
  • an antimicrobial cleaning composition containing 15% by weight, 15 to 25% by weight of Eum tree extract, and 10 to 20% by weight of licorice extract as active ingredients is proposed, it is not a fermented extract and is not a feminine cleansing agent, but Propionibacterium acnes) is emphasized.
  • the present invention is propolis; Collagen peptide; And pulverizing a natural extract selected from the group consisting of allantoin, aloe vera, ginkgo biloba extract, angelica extract, centella asiatica extract, and mixtures thereof to prepare a pulverized product.
  • Preparing a first mixture by placing the pulverized material in a 20 to 50 mesh sieve and classifying it; Water-soluble vitamins; Water-soluble legal sulfur; And preparing a second mixture by placing and classifying the disintegrant in a 20 to 50 mesh sieve.
  • the average particle diameter of the final prepared composition powder may be 1 to 100 ⁇ m.
  • the average particle diameter of the final prepared composition powder may be 50 to 100 ⁇ m.
  • the mixing ratio of the propolis and the natural extract may be a weight ratio of 1:1 to 1:5.
  • the water-soluble vitamin may be selected from the group consisting of vitamin C, vitamin B1, vitamin B2, niacin, vitamin B6, vitamin B12, folic acid, and biotin.
  • the disintegrant may be selected from the group consisting of crospovidone, sodium starch gluconate, croscarmellose sodium, polysorbate, sodium lyryl sulfate, and mixtures thereof.
  • the propolis may be 0.5 to 2.5% by weight of the final prepared granule powder.
  • the legal sulfur may be 1 to 5% by weight of the final prepared granule powder.
  • composition powder for feminine cleansers comprising propolis and natural extract according to an embodiment of the present invention is propolis; Collagen peptide; A natural extract selected from the group consisting of allantoin, aloe vera, ginkgo biloba extract, angelica extract, centella asiatica extract, and mixtures thereof; And water-soluble legal-made sulfur.
  • Propolis is a natural antibacterial substance as a mixture of resinous substances that bees collect from plants such as tree buds and sap. It has antibacterial, bactericidal action and immunity activation, immune function enhancement, cell activation and cell regeneration, anti-allergic action, gene damage defense action, blood vessel reinforcement action, antioxidant action, and anticancer drug side effect reduction action. Also, propolis works to control symptoms.
  • Allantoin is a natural extract extracted from wheat shoots, comfrey roots, oak, tobacco seeds, sugar beets, and the like. It promotes the regeneration of healthy skin cells by directly or indirectly activating cell activities, and plays a role in rebuilding intact granulation tissue. It is not toxic and irritating enough to be listed in the FDA, and has the advantage of exerting an effect even at low concentrations.
  • the aloe vera is a representative aloe species used for commercial or medicinal purposes, and usually has excellent medicinal properties when it has been cultivated for at least 3 years. However, since it is a tropical crop, cultivation in Korea requires a relatively high cost, and processed products imported from foreign countries have a problem of inconsistent quality due to uneven cropping and unbalanced supply and demand.
  • Aloe vera removes the toxic thick skin of leaves and separates only the inner gel, which is a cumbersome process in the actual Aloe related product production stage.
  • Aloe saponaria is used as a raw leaf Aloe has mild medicinal properties and can be used as a skin, but it belongs to a small species among plants of the genus Aloe .
  • Ginkgo leaves used in the present invention refers to the leaves of a common ginkgo tree, and ginkgo leaves have improved vascular function, anticancer, and capillary and venous heart function, anti-aging and skin soothing effects.
  • Angelica has known various pharmacological effects. Representatively, it has been found that anemia treatment, sedation, analgesic effect, tonic, menstrual pain treatment, menopausal symptom treatment, abdominal pain treatment, wound treatment, arthritis treatment, diabetic hypertension treatment. lost. It is known that there are various substances of the coumarin family in Angelica, and it was reported long ago (1967) that a large amount of decursin and decursinol angelate is contained, and recently, dihydropyrano coumarin-based substances have been reported to have anticancer effects. did.
  • Centella asiatica extract is a plant that originates in the tropical regions of the Indian Ocean and grows ideally at an altitude of 600 meters above sea level in humid and shady, and is also called gotukola, indian pennywork or tiger grass.
  • centella asiaticoside, madecasosside, asiatic acid and madecassic acid, called triterpenoids (saponins) are present in the body, and they regulate collagen synthesis in the human body. It is known to promote blood circulation by strengthening the vestibule, and to help improve memory.
  • the natural extract refers to an extract extracted by a general extraction method that can be extracted by an expert in the art, and the extract may be used in a powder form, but is not limited to the above example.
  • the propolis and natural extracts are included in a weight ratio of 1:1 to 1:5, preferably 1:3 to 1:5, but are not limited to the above examples.
  • the propolis is included for antibacterial, anti-inflammatory and antioxidant effects, and natural extracts are included for skin trouble relief, moisturizing, skin softening, skin elasticity, skin regeneration, improved blood circulation, and soothing sensitive skin.
  • propolis is included in the composition for feminine cleansing, it may exhibit antibacterial, anti-inflammatory and antioxidant effects for the prevention or treatment of vaginal-related diseases, but this may cause skin irritation. And, in the present invention, this problem is to be solved by additionally including a natural extract.
  • propolis and natural extract are less than 1:1, that is, when the natural extract is less than the weight of the propolis, there is a problem that skin irritation is caused by propolis, and 1:5 Excess, that is, when more natural extracts are included in comparison to the weight of propolis, the anti-inflammatory, antibacterial and antioxidant effects of propolis are insufficient, and thus the prevention and treatment effect of vaginal-related diseases may decrease.
  • the natural extract is selected from the group consisting of allantoin, aloe vera, ginkgo biloba extract, angelica extract, centella asiatica extract, and mixtures thereof, and in more detail may include allantoin, aloe vera, ginkgo biloba extract, angelica extract and centella asiatica extract. .
  • composition for feminine cleansing agent may further contain black yeast and chitosan in addition to natural extracts.
  • the black yeast (Aureobasidium pullulans) is known to be excellent in moisturizing, elasticity, and atopic pruritus, and the chitosan is effective in increasing the discharge of heavy metals and fine dust, excellent antibacterial effect, and moisturizing effect.
  • the black yeast and chitosan may be additionally included in the composition for a female cleanser, thereby exhibiting moisturizing, skin elasticity, and excellent antibacterial effects.
  • the water-soluble vitamin may be selected from the group consisting of vitamin C, vitamin B1, vitamin B2, niacin, vitamin B6, vitamin B12, folic acid, and biotin, but preferably includes vitamin C, that is, ascorbic acid. , Is not limited to examples.
  • the water-soluble vitamin preferably ascorbic acid, is included in order to exhibit an anti-inflammatory effect by maintaining the pH in the vagina to be weakly acidic.
  • composition for feminine cleansers used sodium salt, lactic acid buffer solution, etc. in order to maintain the pH in the vagina as weakly acidic. While this is an ingredient added to maintain a weakly acidic pH in the vagina, ascorbic acid in the present invention has antioxidant effects, growth and recovery of skin tissue, prevention of cancer-causing substances, etc., as well as maintaining a weakly acidic environment in the vagina. Can show the effect of.
  • the disintegrant is selected from the group consisting of crospovidone, sodium starch gluconate, croscarmellose sodium, polysorbate, sodium lyryl sulfate, and mixtures thereof, and more specifically crospovidone (crospovidone CL-SF), It is not limited to the above example.
  • the composition for a feminine cleanser contains 0.1 to 1.5% by weight of collagen peptide, 0.1 to 1.5% by weight of allantoin, 0.1 to 1.5% by weight of aloe vera, 0.1 to 1.5% by weight of ginkgo biloba extract, 0.1 to 1.5% by weight of Angelicae extract.
  • Wt% Centella asiatica extract 0.1 to 1.5 wt%, chitosan 0.1 to 1.5 wt%, black yeast 0.1 to 1.5 wt%, propolis 0.2 to 3.0 wt%, prosolve 15 to 30 wt%, starch 15 to 30 wt%, microcrystalline It may contain 10 to 20% by weight of cellulose, 20 to 40% by weight of mannitol, 0.5 to 5% by weight of water-soluble vitamins, 1 to 10% by weight of crospovidone, and 0.5 to 5% by weight of magnesium stearate.
  • the composition for feminine cleansing agent contains less than 0.2% by weight of propolis, a problem of insufficient antibacterial, anti-inflammatory and antioxidant effects occurs, and when it contains more than 3.0% by weight, problems of rash and shortness of breath may occur. . Therefore, the preferred range of propolis in the total composition is 0.5 to 2.5% by weight.
  • the collagen peptide When the collagen peptide is included in an amount of less than 0.1% by weight based on the total weight, there is a problem that the elasticity enhancement and skin regeneration effect is insufficient, and when it is included in more than 1.5% by weight, acne occurrence and allergic reactions are caused. have.
  • the allantoin When the allantoin is included in an amount of less than 0.1% by weight based on the total weight, skin trouble relief, moisturizing and skin softening effects are insufficient, and when it is included in an amount exceeding 1.5% by weight, redness occurs due to skin irritation and hot skin. Feelings can arise.
  • the aloe vera is 100:1 aloe vera, and when the aloe vera is contained in an amount of less than 0.1% by weight based on the total weight, there is a problem that the effect of skin elasticity and skin regeneration is insufficient, and in excess of 1.5% by weight If included, diarrhea, abdominal pain, nausea, vomiting and electrolyte disturbances may occur.
  • the ginkgo biloba extract When the ginkgo biloba extract is contained in an amount of less than 0.1% by weight based on the total weight, the effect of improving blood circulation and preventing aging is insufficient, and when it is included in more than 1.5% by weight, problems of vomiting, diarrhea, fever, and abdominal pain may occur.
  • Angelicae extract When the Angelicae extract is contained in an amount of less than 0.1% by weight based on the total weight, skin elasticity enhancement and skin regeneration effect is insufficient, and when it is included in more than 1.5% by weight, diarrhea and fever may occur.
  • centella asiatica extract When the centella asiatica extract is included in an amount of less than 0.1% by weight based on the total weight, the soothing effect of sensitive skin is insufficient, and when it is included in more than 1.5% by weight, itching and swelling of the skin may occur.
  • the chitosan and black yeast may be included in an amount of 0.1 to 1.5% by weight, respectively, based on the total weight, preferably, the chitosan may be included in an amount of 0.5 to 1% by weight, and the black yeast may be included in an amount of 0.5 to 1% by weight. , Is not limited to the above example.
  • the chitosan When the chitosan is included in an amount of less than 0.1% by weight based on the total weight, there is a problem that the antibacterial effect and the moisturizing enhancing effect are insufficient, and when it exceeds 1.5% by weight, skin irritation may occur.
  • the black yeast When the black yeast is included in an amount of less than 0.1% by weight based on the total weight, there is a problem that the moisturizing and elasticity effect is insufficient, and when it exceeds 1.5% by weight, skin irritation may occur.
  • the step 1) is propolis; Collagen peptide; And a natural extract selected from the group consisting of allantoin, aloe vera, ginkgo biloba extract, angelica extract, centella asiatica extract, and mixtures thereof to prepare a pulverized product.
  • the natural extract includes a mixture of allantoin, aloe vera, ginkgo biloba extract, angelica extract and centella asiatica extract, and the natural extract may be an extract in the form of a powder.
  • the pulverized product After preparing the pulverized product by the step 1), 2) the pulverized product may be put into a 20 to 50 mesh sieve and classified to prepare a first mixture.
  • step 2) After step 2), 3) water-soluble vitamins; Water-soluble legal sulfur; And the disintegrant may be put in a 20 to 50 mesh sieve and classified to prepare a second mixture.
  • step 4 the first mixture and the second mixture prepared as described above are mixed and then compressed to remove moisture to less than 10% of the remaining moisture.
  • Step 4) is a basic process step to enhance storage stability by sufficiently removing moisture, and to powder it so that it can be easily dissolved and used in water when used.
  • step 5 it is meaningful to remove moisture as much as possible to further enhance storage stability and, when packaged in a pouch, remove moisture as much as possible so that defects do not occur in the pouch state due to evaporation of moisture. It is recommended to remove moisture as much as possible in step 5), but it is not economically desirable because energy costs are excessive to remove moisture to a level that is too low.
  • the dried feminine cleaner composition powder is pulverized to produce granules of a certain size.
  • the dried feminine cleaner composition powder is pulverized to produce granules of a certain size.
  • the composition is for the prevention or treatment of vaginal-related diseases, and the vaginal-related diseases are vaginosis, vaginal dryness or vaginitis, have excellent effects in inhibiting vaginosis or vaginal dryness, and are excellent in the prevention or treatment of vaginitis.
  • the effect was confirmed, and diseases related to vagina are not limited to the above examples.
  • the feminine cleaner composition powder of the present invention can be used by dissolving in water during use, and is characterized by easy portability and storage, and increased convenience in use. Accordingly, the female cleanser composition powder according to the present invention may be packaged and stored in a pouch in a predetermined amount, for example, 30 to 50 g.
  • the feminine cleaner composition powder according to the present invention may be prepared by adding a solubilizing aid, an emulsifying agent, a buffering agent for pH adjustment, and the like.
  • a solubilizing aid such as sodium sulfate
  • an emulsifying agent such as sodium sulfate
  • a buffering agent for pH adjustment such as sodium sulfate
  • the non-aqueous solvent or suspension solvent propylene glycol, polyethylene glycol, vegetable oil such as olive oil, and injectable ester such as ethyl oleate may be used.
  • the amount of use per time of the composition for feminine cleansing agent may vary depending on the condition and weight of the user, the degree of disease, the drug type, the route and duration of administration, and may be appropriately selected by those skilled in the art. .
  • the dosage of the composition for feminine cleansing agent may be appropriately selected by those skilled in the art in consideration of the administration method, the age, sex and weight of the user, and the severity of the disease. In one embodiment, based on the composition, it may be administered in 0.0001mg/kg to 1000mg/kg, and in order to be more effective, 0.01mg/kg to 100mg/kg. Administration may be administered once a day, or may be divided several times. The above dosage does not in any way limit the scope of the present invention.
  • composition for a feminine cleanser may further include a compound having a known vaginosis or vaginal dryness inhibiting activity, a compound having vaginitis inhibiting activity, or a natural extract in addition to the antibacterial composition.
  • the composition for a female cleanser according to an embodiment of the present invention can be applied directly to animals including humans.
  • the animal is a group of organisms corresponding to plants, mainly ingesting organic matter as nutrients, and refers to that the digestion, excretion and respiratory organs are differentiated, and in detail, it may be a vertebrate, more specifically, a mammal. Specifically, the mammal may be a human.
  • composition powder for feminine cleansing agent comprising propolis and natural extracts of the present invention
  • it can exhibit excellent effects in the prevention or treatment of diseases related to the vagina.
  • the present invention including propolis and natural extracts, exhibits excellent effects in the prevention or treatment of vaginosis, vaginal dryness, or vaginitis, and has little irritation when used, and is made of natural products, so that safe use is possible.
  • 1 is a flow chart for a method of manufacturing a composition powder for a female cleanser according to an embodiment of the present invention.
  • FIG. 2 is a photograph of a powder product sample for a female cleanser composition according to an embodiment of the present invention.
  • Radish juice (non-extracted liquid) was added thereto, and the jijang water was heated again and boiled for 6 hours while maintaining at 100°C, and then allowed to stand at room temperature for 12 hours to cool (five times heating and cooling).
  • 100L of Jijang water was added again, and then ginger juice (ginger extract) was added, stirred and heated again, boiled for 6 hours while maintaining at 100°C, and allowed to stand at room temperature for 12 hours. Cooled (6th heating and cooling). Seomoktae extract was added thereto, and the jijang water was heated again and boiled for 6 hours while maintaining at 100°C, and then allowed to stand at room temperature for 12 hours to cool (7th heating and cooling).
  • Licorice extract was added again, and Jijang water was heated again and boiled for 6 hours while maintaining at 100°C, and then allowed to stand at room temperature for 12 hours to cool (8 times heating and cooling). After the supernatant was removed and the precipitate was recovered, 100 L of jijang water was added again, and the Bupyeongcho extract was added thereto, followed by stirring and heating again, boiled for 6 hours while maintaining at 100°C, and allowed to stand at room temperature for 12 hours to cool ( 9th heating and cooling).
  • the supernatant was removed, the precipitated sulfur component was recovered, and the moisture was removed by pressing it into an oil press.
  • the solid material from which moisture was first removed was put in a dryer and dried, and then moved to a grinder to prepare a fine and fine powder-formed sulfur powder.
  • a solution was prepared by adding three kinds of ash, rice hull material, purslane material, and white skin material to purified water, and marinated for one day, and then the prepared legal sulfur powder was added to the solution.
  • the legal sulfur powder and the three ash were added in a ratio of 1:2, and the legal sulfur powder was added in an amount of 25kg based on 50L of purified water.
  • the solution was heated at 120° C. for 2 hours. This was transferred to a dryer and dried for one week, and the obtained solid was pulverized into a fine powder to prepare a water-soluble legal sulfur powder. It was confirmed that 30% of the final obtained water-soluble legal sulfur powder was lost in the weight of the initially added natural mineral sulfur.
  • the legal sulfur powder prepared as described above was mixed with the basic raw materials for the female cleansing composition to finally prepare the female ⁇ payment composition powder of the present invention.
  • Collagen peptide 0.3% by weight, allantoin 0.1% by weight, aloe vera 100:1 0.1% by weight, ginkgo biloba extract 0.1% by weight, Angelicae extract 0.1% by weight, Centella asiatica extract 0.3% by weight, and propolis 0.5% by weight were pulverized with a mixer, and 30 Classified through a mesh sieve to prepare a first mixture.
  • Prosolve SMCC90 25.56 wt%, Starch1500 20.77 wt%, microcrystalline cellulose PH102 14.84 wt%, mannitol 160C 29.67 wt%, ascorbic acid 1.13 wt% and crospovidone CL-SF 4.45 wt% were placed in a 30 mesh sieve and classified.
  • a second mixture was prepared, and the first mixture and the second mixture were mixed.
  • the first and second mixtures were well mixed, and then compressed to remove moisture to a residual amount of 10% or less. Thereafter, the raw material for the composite composition from which moisture was removed was dried with hot air at 60 to 90° C. for 2 hours, and the moisture residual amount was less than 5%.
  • composition powder for feminine cleaners dried in the drying step was pulverized to prepare granules of a certain size so that the average particle diameter distribution was 75 ⁇ m, to prepare the composition of Experiment No. IV 1.
  • compositions of Experiment Nos. IV 2 to 10 were prepared by varying only the content of each component, and the preparation method was prepared in the same manner as in IV 1.
  • composition for feminine cleaners of Experiment No. IV 1 to 10 More specific contents of the composition for feminine cleaners of Experiment No. IV 1 to 10 are shown in Table 1 below, and the total content was prepared in the form of a pouch by adjusting the content of the excipient.
  • a powder for a feminine cleaner was prepared in the same manner as in the method for preparing the composition of Experiment No. IV 1 above.
  • the content of specific components is shown in Table 2 below.
  • IV 1 IV 2 IV 3 IV 4 IV 5 IV 6 IV 7 IV 8 IV 9 IV 10 #One ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ #2 ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ #3 ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ #4 ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ #5 ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇
  • IT1 to IT 6 it was confirmed that overall skin irritation was improved when compared to IV 1 to 10, and in particular, IT3 and IT4 received the best evaluation.
  • IV1 to IV3 and IV 5 received excellent evaluations in detergency, cleanliness, fragrance, and overall preference, and among them, IV2, IV3 and IV5 received the best evaluation.
  • composition for feminine cleaners containing chitosan, black yeast and legal sulfur also received an excellent overall evaluation, but in particular, IT3 and IT4 received the best evaluation.

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Abstract

La présente invention concerne un procédé de préparation d'une poudre de composition pour un lavage féminin contenant de la propolis et des extraits naturels, la poudre de composition pour un lavage féminin contribuant à des améliorations en termes de facilité d'utilisation, de commodité de stockage et de durée de conservation d'un produit de composition pour un lavage féminin.
PCT/KR2020/008349 2019-07-09 2020-06-26 Procédé de préparation de poudre de composition pour lavage féminin contenant de la propolis et un extrait naturel WO2021006507A1 (fr)

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Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20010025970A (ko) * 1999-09-02 2001-04-06 김희성 프로폴리스 함유 여성용 청결제 조성물 및 그 제조방법
KR101577932B1 (ko) * 2015-07-10 2015-12-16 박호 수용성 법제유황 분말의 제조방법
KR101791840B1 (ko) * 2017-06-30 2017-10-31 에이치앤비 주식회사 불함수능 바이오셀룰로오스 분말, 그 제조방법 및 그를 이용한 화장품
KR101951733B1 (ko) * 2017-10-11 2019-02-25 (주)인벤티지랩 프로폴리스 및 천연 추출물을 포함하는 여성 청결제용 조성물 및 이의 제조 방법

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101797727B1 (ko) 2013-01-16 2017-11-15 주식회사 코리아나화장품 마일드한 여성청결제 조성물

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20010025970A (ko) * 1999-09-02 2001-04-06 김희성 프로폴리스 함유 여성용 청결제 조성물 및 그 제조방법
KR101577932B1 (ko) * 2015-07-10 2015-12-16 박호 수용성 법제유황 분말의 제조방법
KR101791840B1 (ko) * 2017-06-30 2017-10-31 에이치앤비 주식회사 불함수능 바이오셀룰로오스 분말, 그 제조방법 및 그를 이용한 화장품
KR101951733B1 (ko) * 2017-10-11 2019-02-25 (주)인벤티지랩 프로폴리스 및 천연 추출물을 포함하는 여성 청결제용 조성물 및 이의 제조 방법

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
COSTANTINO, M. et al. Irrigazioni vaginali sulfuree e atrofia vulvo-vaginale nel climaterio: studio pilota su efficacia e sicurezza. Clin Ter. 2017, vol. 168, no. 5, pp. e300-306. See abstract. *

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