WO2021000566A1

WO2021000566A1 - Novel objective lens array applied to multi-field parallel imaging

Info

Publication number: WO2021000566A1
Application number: PCT/CN2020/071386
Authority: WO
Inventors: 于綦悦; 唐玉豪; 何俊峰; 吴庆军; 邓建; 刘亚鸿
Original assignee: 达科为（深圳）医疗设备有限公司
Priority date: 2019-07-01
Filing date: 2020-01-10
Publication date: 2021-01-07
Also published as: CN110244442A

Abstract

Provided is a novel objective lens array applied to multi-field parallel imaging, which is an array type microscopic optical imaging system realized by a plurality of small microscopic objective lens units in a certain arrangement mode, and can simultaneously perform imaging with microscopic magnification on different parts of a same tissue section, so as to achieve the goals of simultaneous observation of multiple microscopic fields and high-speed scanning of a digital pathological full section. Each small microscopic objective lens unit is a catadioptric objective lens optical system, which includes a first lens (302) and a second lens (402) once along its optical axis direction, both the first lens (302) and the second lens (402) are meniscus lenses, and the front surface of the first lens (302) and the rear surface of the second lens (402) are respectively plated with optical media splitting films (301, 403). The present invention simply achieves the maximum diffraction path of light in the system, reaches the diffraction limit, and realizes the large-field-of-view high-performance small microscopic objective lens unit and the novel objective lens array composed thereof.

Description

A new type of objective lens array for multi-field parallel imaging

Technical field

The present invention relates to the field of optical imaging, in particular to a novel objective lens array optical system for multi-field parallel imaging composed of a plurality of large-field high-performance small microscopic objective lenses.

Background technique

Microscope objective lens is one of the indispensable important optical components in the optical microscope system. It is used at the front end of the microscope equipment and is the first lens in the microscope optical system that receives the light of the object being observed. Generally speaking, a microscope objective lens is composed of an entrance pupil lens, an aperture stop, an intermediate lens or a combination of an intermediate lens, and an exit pupil lens. Its function is to enlarge the local area of the observation object to realize people's observation of the microscopic world. The light from the observed object first passes through the entrance pupil lens and irradiates into the lens barrel, and then is enlarged under the action of the aperture stop and the intermediate lens, and finally shines out of the lens barrel through the exit pupil lens to achieve a clear Imaging.

The performance of a single microscope objective mainly consists of: numerical aperture, field of view, magnification, and effective focal length. The numerical aperture describes the size of the light-receiving cone angle of the objective lens, which directly determines the light-receiving ability and optical resolution of the microscope objective. For example: the larger the numerical aperture, the stronger the light-receiving ability of the microscope objective, and the higher the optical resolution; It is the range of observation objects that can be magnified and imaged by the microscope objective. The magnification is the ratio of the field of view to the imaging area. Generally, when the imaging area is fixed, the larger the magnification, the smaller the field of view, and the greater the number of intermediate lenses required. More (usually larger than three lenses) to suppress the aberration of high-magnification imaging; the effective focal length is the distance from the principal point of the optical system to the focal point on the optical axis. The smaller the effective focal length, the greater the magnification, and the smaller the field of view. The larger the numerical aperture.

The traditional microscope objective lens has a small field of view and a large lens barrel. It cannot simultaneously observe cell tissues in different parts of the same distance. For example, a traditional objective lens with a magnification of 40 times has a barrel diameter of 24 mm and a field of view of 0.5 mm. Within the diameter of 24 mm, the observation area is only the central area of 0.5 mm in diameter. The other areas are blocked by the huge objective lens barrel, and microscopic observation is not possible. To observe other areas, the microscope optical system must be moved Or tissue section.

Therefore, when simultaneous microscopic observation of different cell tissues at similar distances is required, traditional objective lenses cannot meet the demand. For example, when performing microscopic observation on Tissue Microarray (TMA), different tissue specimens are closely arranged in a regular array on the same glass slide. Simultaneous microscopic imaging of these tissue specimens is required to improve the microscopic observation Efficiency, reducing diagnostic burden and errors, while using traditional objective lenses, each tissue can only be observed and diagnosed one by one, which is extremely inefficient and easy to cause misdiagnosis; in addition, a digital pathology scanner is used to digitize a slice of tissue For full-slice imaging, simultaneous imaging and scanning of different parts of the tissue slice are required to achieve high-speed scanning to improve the efficiency of digital pathological diagnosis. However, when traditional objective lenses are used, only microscopic images of the sliced tissue can be performed one by one. Shooting and then stitching the images will not only cause cumulative errors in full-slice imaging, but also have extremely low efficiency, which affects the realization of efficient diagnosis and cannot fully reflect the value of digital pathology in clinical pathological diagnosis.

In summary, a new type of objective lens array for multi-field parallel imaging is needed to improve the shortcomings of existing optical microscopes that only one microscopic field can be observed at the same time, and to meet the needs of simultaneous microscopic observation of multiple microscopic fields.

Summary of the invention

According to the above-mentioned problems and improvement needs of traditional microscope objectives, the present invention provides a novel objective lens array applied to multi-field parallel imaging, which can be applied to the field of optical microscope, especially the field of ultra-high-speed digital pathology imaging and microscopic imaging.

The present invention provides a novel objective lens array applied to multi-field parallel imaging, and its imaging principle is as follows:

A new type of objective lens array applied to multi-field parallel imaging, an array type microscopic optical imaging system realized by a plurality of identical large-field high-performance small microscope objective lens units arranged in a quadrangular matrix; the objective lens array is The optical axis direction includes a first lens array and a second lens array in sequence; the microscopic objective lens unit includes a first lens located in the first lens array and a second lens located in the second lens array, the first lens and the second lens array The second lens is opposite; each small microscopic objective lens unit is a catadioptric objective lens. The small microscopic objective lens unit, first, along its optical axis, from the surface of the object to be observed (object surface) to the imaging surface (image surface) includes a first lens and a second lens, the first lens is curved For the lunar lens, the front surface facing the object surface is concave, and the rear surface facing the image surface is convex; the second lens is a meniscus lens, the front surface facing the object surface is concave, and the rear surface facing the image surface is convex; The curvatures of the front and rear surfaces of the first lens and the second lens are different; the aperture stop array is located at the rear surface of the first lens array.

In the small objective lens unit, along its optical axis, the front surface of the first lens and the back surface of the second lens are both coated with a transflective optical medium spectroscopic film, and the transflective optical medium spectroscopic film is a This kind of optical coating can make the incident light pass along the incident direction and continue to propagate, and at the same time make the incident light reflect in the opposite direction of the incident and continue to propagate in the opposite direction of the incident. The light that passes through and continues to propagate in the incident direction is the transmitted light, The light emitted in the opposite direction of the incident and continuing to propagate in the opposite direction of the incident is reflected light. According to the law of conservation of energy, the sum of the energy of the reflected light and the transmitted light is equal to the energy of the incident light, which is specifically reflected in the intensity of the reflected light and the transmitted light. The sum is equal to the intensity of the incident light.

In the small objective lens unit, all lenses are made of glass with low melting point and high and low dispersion.

The above-mentioned material high and low dispersion matching, that is, the first lens selects high-dispersion material glass and the second lens selects low-dispersion material glass, or the first lens selects low-dispersion material glass and the second lens selects high-dispersion material glass, through the above-mentioned high-low dispersion The combination of materials, which makes the optical dispersion compensate each other, realizes the elimination of chromatic aberration and the improvement of image quality.

The imaging principle of the small microscopic objective lens unit is as follows: along the optical axis, light from the observed object irradiates the front surface of the first lens, and passes through the first semi-transmissive and semi-reflective optical medium splitting film, and a part of the light It is reflected outside the optical system without imaging. Another part of the light enters the optical system through the film to form incident light. The incident light entering the optical system passes through the first lens and exits from the back surface of the first lens. The air gap between the second lens is incident on the front surface of the second lens and irradiated on the back surface of the second lens. Part of the light passes through the second semi-transparent and semi-reflective optical medium splitting film on the back surface of the second lens. The film exits the optical system to form divergent light with weak illumination intensity and illuminate the image surface. Another part of the light is reflected and converged and irradiated into the first lens according to the curvature of the second lens. The first semi-transmissive and semi-reflective optical medium light splitting film passing through the front surface of the first lens, according to the curvature of the front surface of the first lens, converges and illuminates the back surface of the second lens, and passes through the second semi-transparent and semi-reflective The optical medium light-splitting film continues to converge to form a concentrated focal point with strong light intensity, and the focal point position is the image plane position.

According to the above-mentioned imaging principle, the light component on the image plane is divergent, completely transmitted light without a focal point, and convergent multiple reflected light that forms an imaging focal point. The irradiation of multiple reflected light is much higher than that of a complete Transmitted light. In imaging, completely transmitted light is noise, and multiple reflected light is imaging. Therefore, the signal-to-noise ratio of imaging contrast noise is high. Even if there is completely transmitted light, it will not have a great impact on clear imaging.

Further, the aforementioned first lens and second lens are circular lenses, and there is a gap between the first lens and the second lens; the gap can be filled with air or liquid, or the gap can be equipped with other lenses that meet higher imaging requirements. Lens and other lens combinations.

Further, the front surface and the back surface of the aforementioned first lens are aspherical surfaces or custom curved surfaces, and the front and back surfaces of the second lens are aspherical surfaces or custom curved surfaces. Using aspherical or self-defined curved surfaces can make the design of the optical system easier to meet the requirements of miniaturization, and it is also easier to optimize the design of the optical system to fully meet the system performance requirements. In the case of using a traditional spherical surface, a larger area lens or a longer optical system distance is required to meet the performance requirements of the optical system. Simply put, the use of an aspheric surface or a custom curved surface is required for miniaturization and high performance of the optical system. Under the constraints of, the optimization of the optical system design is more perfect, and the spherical surface cannot meet the constraints of high performance requirements and miniaturization requirements at the same time.

Furthermore, the aforementioned quadrilateral matrix arrangement is a rectangular objective lens array formed by a plurality of small microscopic objective lens units with large field of view and high performance arranged side by side.

Compared with the prior art, the novel objective lens array for multi-field parallel imaging and its components: a small microscopic objective lens unit with a large field of view and high performance has the following performance advantages:

(1) The catadioptric structure is adopted in the small microscopic objective lens unit with large field of view and high performance of the present invention, which can not only realize the high-performance optical microscopic objective lens with a very small number of lenses, but also increase the transmission of light in the optical system. The path length has reached its diffraction limit, and the optical performance of the two lenses is brought into full play;

(2) The small microscopic objective lens with large field of view and high performance of the present invention reduces the number of lenses while ensuring high performance, resulting in a great reduction in volume, a great saving in production costs, and a great reduction in production difficulty ；

(3) The large-field high-performance small microscopic objective lens of the present invention can realize the convergence of imaging light, form a high-energy imaging focus, greatly improve the signal-to-noise ratio of imaging, and achieve high-quality clarity in a large microscopic field of view Imaging

(4) The novel multi-field parallel imaging objective lens array of the present invention is an array optical system composed of two lens arrays. The first lens array facing the object surface is a plurality of small microscopic objective lens units with large field of view and high performance. The first lens of the object surface is integrated into a lens array by processing, and the second lens array facing the image surface is a plurality of the above-mentioned large-field and high-performance small microscope objective lens units. The second lens facing the image surface is integrated into one by processing. The lens array of the lens. The above-mentioned first lens array and second lens array form a new objective lens array, which can simultaneously perform microscopic imaging of multiple tissue regions in similar positions, effectively realizing efficient pathological tissue chip observation and diagnosis, and high-speed digital pathological scanning.

The above description is only an overview of the technical solution of the present invention. In order to understand the technical means of the present invention more clearly and implement it in accordance with the content of the description, the preferred embodiments of the present invention are described in detail below with the accompanying drawings.

Description of the drawings

FIG. 1 is the structure and optical path diagram of the optical system of a large-field high-performance small microscopic objective lens unit in the novel objective lens array for multi-field parallel imaging of the present invention;

2 is a structural diagram of the first lens of the optical system of a large-field high-performance small-scale microscopic objective lens unit in the novel objective lens array for multi-field parallel imaging according to the present invention;

3 is a structural diagram of the second lens of the optical system of a large-field high-performance small-scale micro-objective lens unit in the novel objective lens array for multi-field parallel imaging according to the present invention;

FIG. 4 is a diagram of the modulation transfer function MTF of the optical system of a large-field high-performance small-scale microscope objective lens unit in the novel objective lens array for multi-field parallel imaging of the present invention;

5 is a light fan diagram of the longitudinal section of the optical system of a large-field high-performance small-scale micro-objective lens unit in the novel objective lens array for multi-field parallel imaging of the present invention;

6 is a light fan diagram of the cross-section of the optical system of a large-field high-performance small-scale microscope objective lens unit in the novel objective lens array for multi-field parallel imaging of the present invention;

Fig. 7 is a longitudinal section of the optical path fan diagram of the optical system of a large-field high-performance small-scale microscope objective lens unit in the novel multi-field parallel imaging objective lens array of the present invention;

8 is a cross-sectional optical path fan diagram of the optical system of a large-field high-performance small-scale microscopic objective lens unit in the novel objective lens array for multi-field parallel imaging of the present invention;

FIG. 9 is a point diagram of the optical system of a large-field high-performance small microscopic objective lens unit in the novel objective lens array for multi-field parallel imaging of the present invention;

FIG. 10 is a view field curve diagram of an optical system of a large-field high-performance small microscopic objective lens unit in a novel objective lens array for multi-field parallel imaging according to the present invention;

FIG. 11 is a distortion diagram of the optical system of a large-field high-performance small microscopic objective lens unit in the novel objective lens array for multi-field parallel imaging according to the present invention;

Fig. 12 is a cross-sectional view of a novel objective lens array for multi-field parallel imaging of the present invention.

Fig. 13 is an imaging schematic diagram of a novel objective lens array for multi-field parallel imaging according to the present invention.

Reference signs: 1-object plane, 2-cover glass, 301-first transflective optical medium spectroscopic film, 302-first lens, 303-rear surface of first lens, 401-front surface of second lens, 402-Second lens, 403-Second semi-transparent and semi-reflective optical medium spectroscopic film, 5-Image plane.

Detailed ways

The technical solutions in the embodiments of the present invention will be clearly and completely described below in conjunction with the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only a part of the embodiments of the present invention, rather than all the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without creative work shall fall within the protection scope of the present invention.

It should be noted that if there is a directional indication (such as up, down, left, right, front, back...) in the embodiment of the present invention, the directional indication is only used to explain that it is in a specific posture (as shown in the drawings). If the specific posture changes, the relative positional relationship, movement, etc. of the components below will also change the directional indication accordingly.

The novel objective lens array optical system applied to multi-field parallel imaging of the present invention will be described in further detail below, but the protection scope of the present invention should not be limited.

The purpose of the present invention is to provide a new type of objective lens array optical system applied to multi-field parallel imaging, to provide the realization of multi-field parallel imaging and microscopic observation and imaging optical system for the field of optical microscopy, especially for the field of digital pathology The realization scheme and imaging optical system of ultra-high-speed and equipment miniaturization, and the realization scheme and imaging optical system of providing multi-field simultaneous observation and diagnosis for the tissue chip field.

An embodiment of an objective lens unit in the novel objective lens array optical system applied to multi-field parallel imaging, the specific performance parameters are: the field of view diameter is 1 mm, the numerical aperture is 0.6, the effective focal length is 0.78 mm, and the entrance pupil diameter It is 1.17 mm, the field of view is 1.17 mm, the total system length is 4.23 mm, the magnification is 5.14 times, the imaging resolution is 0.24 μm/pixel, the working wavelength is visible light wavelength region from 0.4 μm to 0.7 μm, the design wavelength is 0.643 μm, 0.591 microns, 0.542 microns, 0.5 microns, 0.466 microns, of which the design center wavelength is 0.542 microns.

In an embodiment of an objective lens unit in the ultra-small microscopic objective lens optical system with large field of view and high performance, the main performance parameters specifically satisfy the following relationship:

The relationship between the numerical aperture, the refractive index of the working medium and the half angle of the maximum cone angle of the incident light:

NA=n*sinθ--------------------------------------------- --Formula 1

Among them, NA represents the numerical aperture, n represents the refractive index of the working medium, and θ represents the half angle of the maximum cone angle of the incident light.

The relationship between the half-angle of the maximum cone angle of the incident light and the diameter of the entrance pupil and the effective focal length:

tanθ=EPD/(2*EFL)---------------------------------------- 2

Among them, θ represents the half-angle of the maximum cone angle of the incident light, EPD represents the entrance pupil diameter, and EFL represents the effective focal length.

The relationship between imaging resolution, magnification and field of view:

δ=ρ ² /(Mag*U)---------------------------------------- ----Form 3

Among them, δ represents the imaging resolution, ρ represents the pixel size of the image sensor, Mag represents the magnification, U represents the unit length; in this example, ρ is specifically 1.12 microns, U is specifically 1 micron, and Mag is specifically 5.14. Therefore, the imaging resolution The rate is specifically 0.24 microns/pixel.

As shown in Figure 12 and Figure 13, a new type of multi-field parallel imaging objective lens array, an array type microscopic optical imaging system realized by a plurality of identical large-field high-performance small microscope objective lens units arranged in a quadrilateral matrix arrangement . Among them, the quadrilateral matrix arrangement can be a rectangular objective lens array formed by a plurality of small microscope objective lens units with large field of view and high performance arranged side by side spliced.

As shown in FIG. 12, the objective lens array of the present invention includes a first lens array and a second lens array in sequence along its optical axis. The microscope objective lens unit includes a first lens 302 located in the first lens array and a second lens 402 located in the second lens array. The first lens 302 is opposite to the second lens 402. Each small microscope objective lens unit is a catadioptric objective lens. An embodiment of one objective lens unit in the ultra-small microscopic objective lens optical system with large field of view and high performance. Specifically, two optical lenses are used, and the material is glass with high melting point and high and low dispersion. Specifically, the first lens 302 adopts High-dispersion glass with low-dispersion glass for the second lens 402, or low-dispersion glass with the first lens 302 and high-dispersion glass with the second lens 402, such as SCHOTT's NLAF35 material (Vd=-2.6444) No. NSK16 (Vd＝-0.0007) material, or HOYA company’s number NBF2 (Vd＝-0.9575) material with number MBACD15 (Vd＝2.1589) material, or Chengdu Guangming company’s number DLAF82L (Vd＝-2.0274) material with HZK7 (Vd=-0.2680) Materials and so on.

An embodiment of an objective lens unit in the large-field high-performance ultra-compact micro-objective optical system, specifically the object plane 1, the first lens 302, and the second lens 402 respectively arranged from left to right along the optical axis direction , And image plane 5, in which the object plane 1 is located at the far left finite distance, and the image plane 5 is located at the far right finite distance. The front surface of the first lens 302 and the rear surface of the second lens 402 are both plated with a transflective lens Optical media spectroscopic film. The semi-transmissive and semi-reflective optical medium spectroscopic film is specifically: a semi-transparent and semi-reflective optical medium spectroscopic coating, which utilizes its optical performance to realize part of the light incident on the coating surface is transmitted and some is reflected.

An embodiment of an objective lens unit in an ultra-small microscope objective optical system with a large field of view and high performance of the present invention, as shown in Figures 1 to 3, the propagation path of light in the system is specifically as follows: first along the optical axis direction , The light from the observed object irradiates the front surface of the first lens 302 coated with the first transflective optical medium spectroscopic film 301. The front surface of the first lens 302 faces the object surface 1 as a concave surface and the image surface 5 as a convex surface The curvature of the first semi-transmissive and semi-reflective optical medium light-splitting film 301 is the same as the curvature of the front surface of the first lens 302. The incident light is reflected by the coating on the front surface of the first lens 302 without imaging, and the other part of the transmitted light passes through The first lens 302 and its rear surface 303 illuminate the front surface 401 of the second lens 402. The rear surface 303 of the first lens 302 faces the object surface 1 as a concave surface, and the image surface 5 faces the convex surface, and the front surface of the second lens 402 401 faces the object surface 1 as a concave surface, and faces the image surface 5 as a convex surface; the light passes through the front surface 401 of the second lens 402 and irradiates the back surface of the second lens 402 coated with the second semi-transmissive and semi-reflective optical dichroic film 403. The rear surface of the second lens 402 is concave facing the object surface 1 and the image surface 5 is convex. The curvature of the optical coating on the rear surface of the second lens 402 is the same as the curvature of the rear surface of the second lens 402; The light reflected by the light splitting film 403 of the two semi-transmissive and semi-reflective optical medium enters the optical system again, and the light scattered through the optical film on the rear surface of the second lens 402 is irradiated to the image surface 5.

Secondly, the light that enters the optical system again is focused by the second lens 402, enters the first lens 302 again, and is reflected by the first transflective optical medium splitting film 301 on the front surface of the first lens 302, and finally focused and illuminated To the image plane 5; therefore, the image plane 5 has the scattered light transmitted for the first time, and at the same time has the focused refractive reflected light, but because the intensity of the focused light is much greater than the intensity of the scattered light, therefore, the image plane 5 It can be high-definition high-quality microscopic images with high signal-to-noise ratio.

Each lens in the first lens array and the second lens array may be a circular lens. There is an interval between the first lens 302 and the second lens 402. The interval may be filled with air or liquid, or other lenses or other lens combinations may be arranged in the interval. The front surface and the back surface of each lens in the aforementioned first lens array can both be aspherical, and the front and back surfaces of each lens in the second lens array can also be aspherical.

Table 1 shows the design data of one objective lens unit in the ultra-small microscopic objective lens optical system with large field of view and high performance disclosed in the present invention. Table 1 shows the specific design parameter values of each lens surface of an objective lens unit and the semi-transmissive and semi-reflective optical medium spectroscopic film of the above-mentioned embodiment: the ultra-small microscopic objective optical system with large field of view and high performance.

Table 1 The design parameters of an objective lens unit in the ultra-small microscopic objective lens optical system with a large field of view and high performance of the present invention.

FIG. 4 shows the modulation transfer function MTF of an objective lens unit in the ultra-small microscopic objective lens optical system with large field of view and high performance in this embodiment, which is close to the diffraction limit. FIG. 5 shows the light characteristics of the longitudinal section of this embodiment, and FIG. 6 shows the light characteristics of the cross section of the optical system of this embodiment. FIG. 7 shows the optical path characteristic diagram of the longitudinal section of this embodiment, and FIG. 8 shows the optical path characteristic diagram of the cross section of this embodiment. Fig. 9 shows a dot chart of this embodiment. FIG. 10 shows the field of view curve diagram of this embodiment, and FIG. 11 shows the distortion diagram of this embodiment. These performance diagrams all show that the novel objective lens array of the present invention, which is composed of multiple objective lens units and applied to multi-field parallel imaging, has good optical performance, and the imaging quality is close to perfect imaging, which fully meets the requirements of multi-field parallel optical microscopic observation and high-speed digital pathology. Imaging requirements.

What needs to be explained here is that if there is no conflict, those skilled in the art can combine the relevant technical features in the above examples according to the actual situation to achieve the corresponding technical effects. Specifically, the various combinations are not here. Go into details one by one.

The above are only the preferred embodiments of the present invention, and the protection scope of the present invention is not limited to the above-mentioned embodiments. All technical solutions under the idea of the present invention belong to the protection scope of the present invention. It should be pointed out that for those of ordinary skill in the art, several improvements and modifications made without departing from the principles of the present invention should also be regarded as the protection scope of the present invention.

Claims

A novel objective lens array applied to multi-field parallel imaging, characterized in that it is an array type microscopic optical imaging system realized by a plurality of large-field high-performance small microscopic objective lens units in a quadrilateral matrix arrangement;

The objective lens array includes a first lens array and a second lens array in sequence along its optical axis;

The microscope objective lens unit includes a first lens located in a first lens array and a second lens located in a second lens array, the first lens is opposite to the second lens; wherein the surface of the first lens facing the object surface Is the front surface, the surface facing the image surface is the back surface; the surface of the second lens facing the object surface is the front surface, and the surface facing the image surface is the back surface; the first lens and the second lens constitute a catadioptric In the optical system, a first semi-transmissive and semi-reflective optical medium spectroscopic film is plated on the front surface of the first lens, and a second semi-transparent and semi-reflective optical medium spectroscopic film is plated on the back surface of the second lens.
The novel objective lens array applied to multi-field parallel imaging according to claim 1, wherein each lens in the first lens array and the second lens array is a circular lens; between the first lens and the second lens There is a gap; the gap is filled with air or liquid, or there are other lenses or other lens combinations in the gap.
The novel objective lens array applied to multi-field parallel imaging according to claim 1 or 2, wherein the front surface and the back surface of each lens in the first lens array are aspherical, and the second lens array The front and back surfaces of each lens are aspherical.
The novel objective lens array for multi-field parallel imaging according to claim 1 or 2, characterized in that the quadrilateral matrix arrangement is composed of a plurality of large-field high-performance small microscope objective lens units arranged side by side. Rectangular objective lens array.