WO2020258283A1

WO2020258283A1 - Bead removing device, test cup conveying system, and magnetic bead removing method for test cup

Info

Publication number: WO2020258283A1
Application number: PCT/CN2019/093832
Authority: WO
Inventors: 周志奇; 柴亮; 李鑫
Original assignee: 深圳迈瑞生物医疗电子股份有限公司; 北京深迈瑞医疗电子技术研究院有限公司
Priority date: 2019-06-28
Filing date: 2019-06-28
Publication date: 2020-12-30
Also published as: CN114270194A

Abstract

A bead removing device, a test cup conveying system, and a magnetic bead removing method for a test cup. The bead removing device comprises a support (20), a test cup table (10) mounted on the support (20), and a bead removing mechanism (100) mounted on the support (20); the test cup table (10) is provided with a placement seat (11) used for placing a test cup (500); the bead removing mechanism (100) is used for taking out a magnetic bead from the test cup (500) on the placement seat (11). A controller can generate a bead removing operation instruction or a bead retaining operation instruction according to a test item inputted by a user and a test method corresponding to the test item, is simple to operate, and also can reduce test costs.

Description

Bead removing device, test cup transportation system and method for removing magnetic beads of test cup

Technical field

This application relates to the technical field of medical devices, and in particular to a bead removing device, a test cup transportation system, and a method for removing magnetic beads from a test cup.

Background technique

There are currently two detection methods for coagulation analyzers on the market: one is the magnetic bead method, which uses the electrical signal generated by the cutting of the magnetic line of force during the swing of the magnetic bead to monitor the swing amplitude of the magnetic bead. The freezing point is determined to 50%; another detection method is the optical method. The optical hemagglutination meter measures the coagulation function according to the change of turbidity during the plasma coagulation process.

In order to be compatible with both the magnetic bead method and the optical method, the test cup in the existing cup-plate assembly basically encapsulates a magnetic bead. However, using such a cup with magnetic beads for optical testing, because the location of the magnetic beads will cause great interference to the results of the optical measurement, it is often necessary to raise the optical axis to the best measurement area above the magnetic beads. Therefore, more samples and reagents need to be added, causing reagent waste and increasing test costs.

Summary of the invention

This application provides a bead removing device, a test cup transportation system, and a method for removing magnetic beads from the test cup, which can quickly remove the magnetic beads in the test cup according to the test requirements, and reduce the test cost.

According to the first aspect of the embodiments of the present application, there is provided a bead removing device, including a stand, a test cup stand, and a bead removing mechanism. The test cup stand and the bead removing mechanism are both installed on the stand, and the test cup The platform is provided with a placement seat for placing the test cup; the bead removing mechanism is used to take out the magnetic beads in the test cup on the placement seat.

According to a second aspect of the embodiments of the present application, a test cup transportation system is provided, which includes a cup inlet groove, a bead removing device, and a test cup transfer mechanism. The cup inlet groove includes a loading position and an unloading position. The position corresponds to the loading device to receive the test cup with magnetic beads conveyed by the loading device, and the test cup in the cup inlet groove is unloaded through the unloading position; the bead removing device includes a support, a test cup A cup stand and a bead removing mechanism, the test cup stand is installed on the bracket, the test cup table is provided with a placement seat for placing test cups, the bead removing mechanism is installed on the bracket, and is used to The magnetic beads in the test cup on the placement seat are taken out, the support can be movably installed on the unloading position of the cup inlet groove, and the placement seat corresponds to the upper material position of the cup inlet groove, so that the test cup It can enter the placing seat; the test cup transfer mechanism is used to transfer the test cup on the placing seat to the next process.

According to a third aspect of the embodiments of the present application, there is provided a method for removing magnetic beads from a test cup, including:

The controller obtains the test item and test method applied by the current test cup according to the predetermined test item and the corresponding test method of the test item. If the test method corresponding to the test item of the current test cup is not the magnetic bead test method, it outputs the bead removal operation instruction;

The bead removing mechanism is connected with the operation instruction output terminal of the controller, and when the bead removing mechanism receives the bead removing operation instruction, it will take out the magnetic beads in the test cup located in the seat in the test cup table.

The technical solutions provided by the embodiments of this application may include the following beneficial effects: This application designs a bead removing device, a test cup transportation system, and a method for removing magnetic beads of the test cup, including a bracket, a test cup table, and a bead removing mechanism, wherein the test The cup table is provided with a placement seat for placing the test cup, and the bead removing mechanism is used to take out the magnetic beads in the test cup on the placement seat, so that the magnetic beads in the test cup can be taken out according to the test requirements to avoid the magnetic beads from being The optical method can cause interference in the measurement, and it can also reduce reagent waste and reduce test costs.

It should be understood that the above general description and the following detailed description are only exemplary and explanatory, and cannot limit the application.

Description of the drawings

In order to explain the technical solutions of the embodiments of the present application more clearly, the following will briefly introduce the drawings needed in the description of the embodiments. Obviously, the drawings in the following description are some embodiments of the present application. Ordinary technicians can obtain other drawings based on these drawings without creative work.

FIG. 1 is a schematic structural diagram of a test cup transportation system provided by an embodiment of the present application;

2 is a schematic diagram of another state structure of the test cup transport system in FIG. 1;

Figure 3 is a partial exploded schematic diagram of the test cup transport system in Figure 1;

Fig. 4 is a schematic structural diagram of the test cup in Fig. 1 placed in the bead removing device;

Fig. 5 is a schematic structural diagram of another state in which the test cup in Fig. 1 is placed in the bead removing device;

Fig. 6 is a schematic structural diagram of the bead removing device in Fig. 1;

Fig. 7 is an exploded schematic diagram of the bead removing device in Fig. 1;

Figure 8 is a schematic diagram of the structure of the stent in Figure 1;

Fig. 9 is a schematic structural diagram of the stent in Fig. 1 in another state;

Fig. 10 is a schematic structural diagram of the stent in Fig. 1 in another state;

Figure 11 is a schematic diagram of the structure of the bead removing mechanism in Figure 1;

Figure 12 is a schematic structural diagram of another state of the bead removing mechanism in Figure 1;

Figure 13 is a schematic structural diagram of another state of the bead removing mechanism in Figure 1;

14 is a schematic structural diagram of a test cup transportation system provided by another embodiment of the present application;

FIG. 15 is a schematic structural diagram of another state of the test cup transportation system in FIG. 14;

Description of reference signs:

100. Bead removing device;

10. Test cup table; 11. Place seat; 111. Place slot; 112. Bevel chamfer; 12. Rotary table; 121. Limit lug; 122. Notch; 13. Connect shaft; 131. Connect shaft through groove; 20. Bracket; 21. Fixed bracket; 211. Connecting shaft perforation; 22. Bracket body; 221. Connecting shaft through hole; 222. Ball guide groove; 2221. Left side plate; 2222. Right side plate; 2223. Plate; 223, test cup table rotating groove; 224, limit card slot; 2241, second limit member; 2242, first limit member; 30, bead removal mechanism; 31, drive member; 311, output shaft; 32 , Drive assembly; 33, magnetic rod; 34, transverse drive motor; 341, lead screw assembly;

200. Cup-in slot; 201. Feeding position; 202. Unloading position; 2021. Slide rail assembly;

300. Test cup transfer mechanism;

400. Feeding device;

500, test cup.

Detailed ways

The technical solutions in the embodiments of the present application will be described clearly and completely in conjunction with the accompanying drawings in the embodiments of the present application. Obviously, the described embodiments are part of the embodiments of the present application, rather than all of them. Based on the embodiments in this application, all other embodiments obtained by those of ordinary skill in the art without creative work shall fall within the protection scope of this application.

The flowchart shown in the drawings is merely an illustration, and does not necessarily include all contents and operations/steps, nor does it have to be executed in the described order. For example, some operations/steps can also be decomposed, combined or partially combined, so the actual execution order may be changed according to actual conditions.

Hereinafter, some embodiments of the present application will be described in detail with reference to the accompanying drawings. In the case of no conflict, the following embodiments and features in the embodiments can be combined with each other.

As shown in Figures 1 to 4, the present application discloses a test cup transport system, which is applied to a coagulation analysis and detection project. Specifically, the test cup transport system of the present application includes a bead removing device 100 and a cup inlet tank 200 As with the test cup transfer mechanism 300, the cup inlet tank 200 includes a loading position 201 and an unloading position 202, wherein the loading position 201 corresponds to the loading device 400 to receive the test cup 500 with magnetic beads conveyed by the loading device 400 , The test cup 500 in the cup slot 200 is unloaded through the unloading position 202. In this embodiment, the bead removing device 100 includes a test cup table 10, a support 20, and a bead removing mechanism 30. The test cup table 10 is mounted on the support 20. The test cup table 10 is provided with a placing seat 11 for placing the test cup 500. The bead removing mechanism 30 is installed on the support 20 and is used to take out the magnetic beads in the test cup 500 on the placement seat 11. In addition, the bracket 20 can be movably installed on the unloading position 202 of the cup inlet groove 200, and the position of the placing seat 11 corresponds to the position of the loading position 201, so that the test cup 500 can enter the placing seat 11; The mechanism 300 is used to transfer the test cup 500 on the placement seat 11 to the next process.

When the test cup transportation system receives the predetermined test item and the corresponding test method of the test item, the loading position 201 transports the test cup 500 with magnetic beads on the loading device 400 to the placement seat 11, and the bead removing mechanism 30 performs the test according to the test The corresponding test method of the project chooses whether to beaded. For example, when the test method is the magnetic bead method, the bead removing mechanism 30 retains the magnetic beads in the test cup 500 and does not perform any operation on the magnetic beads in the test cup 500, and then moves the bead removal device 100 to the unloading position 202 and passes the test cup. The transfer mechanism 300 transfers the test cup 500 on the placement seat 11 to the next process; when the test method is an optical method, after the bead removal mechanism 30 takes out the magnetic beads in the test cup 500, the bead removal device 100 moves to the unloading position 202 and The test cup 500 on the placement seat 11 is transferred to the next process by the test cup transfer mechanism 300.

After adopting the above technical solution, since the traditional test cup is enclosed in the cup-plate assembly, in order to be compatible with both the magnetic bead method and the optical method at the same time, the test cup in the cup-plate assembly basically encapsulates a magnetic bead. The application can take out or keep the magnetic beads in the cup and tray assembly according to the needs of the test item, which will not affect the inspection results of the reagents, but also will not cause reagent waste and increase test costs.

Among them, the bead removing mechanism 30 in the bead removing device 100 can include any bead removal method, for example, a rotating cylinder drives the test cup table 10 to rotate, so that the magnetic beads slide out from the mouth of the test cup; Take out the magnetic beads in the test cup; you can even use a vacuum chuck to directly attract and take out the magnetic beads in the test cup, or use a magnetic rod to use magnetic force to attract the magnetic beads in the test cup to remove the beads, etc. The purpose is mainly to take out the magnetic beads in the test cup, and at the same time move the test cup to the next process by entering the cup slot 200 to add reagents, and this application does not make any restrictions.

The technical solution of the bead removing mechanism 30 in this application is described in detail below with specific embodiments.

Embodiment 1 As shown in Figures 4 to 13, a bead removing device 100 of this embodiment includes a test cup stand 10, a support 20, and a bead removing mechanism 30, wherein the test cup table 10 and the bead removing mechanism 30 are both installed On the support 20 and the test cup stand 10 is provided with a placing seat 11 for placing the test cup 500, and the bead removing mechanism 30 is used to take out the magnetic beads in the test cup 500 on the placing seat 11.

After adopting the above technical solution, when optical detection is required, the test cup 500 is placed in the placement seat 11, and the bead removing mechanism 30 is used to take out the magnetic beads in the test cup 500, thereby preventing the position of the magnetic beads from affecting the measurement result. It causes interference, and there is no need to add more samples and reagents, which causes reagent waste and increases test costs.

It should be noted that the bead removing mechanism 30 can be embedded in the test cup transportation system and used in series with the test cup transportation system. It is also possible to separately set a buffer position for storing the bead removing mechanism 30. The bead removing mechanism 30 placed at the cache position performs the removal operation on the test cup with magnetic beads, and the test cup is transferred to the next process by the test cup transfer device. The bead removing mechanism 30 can be intelligently controlled, so that the bead removing device 100 can determine whether to take out the magnetic beads in the test cup according to specific items, thereby increasing the test speed of the reagent.

In an alternative embodiment, as shown in FIGS. 4 to 7, the test cup table 10 is rotatably mounted on the support 20. Specifically, the bead removing mechanism 30 includes a driving member 31, an output shaft 311 of the driving member 31 and a tester The cup stand 10 is in a transmission connection for driving the test cup stand 10 to rotate, so that the test cup 500 on the test cup stand 10 placement seat 11 can rotate on a vertical plane with respect to the support 20 under the output power of the driving member 31.

Specifically, when the test cup 500 is placed in the placing seat 11, the driving member 31 is in the initial state, and the cup mouth of the test cup 500 is facing upwards; if the bead removing device 100 is flat on the placing surface, the mouth of the test cup 500 The end face is just parallel to the horizontal line (as shown in Figure 4); when it is necessary to take out the magnetic beads placed in the test cup 500 on the placement seat 11, the driving member 31 starts and drives the test cup table 10 to rotate, and the test cup 500 follows the test cup table 10 together Rotate (as shown in Figure 5), when the test cup table 10 is rotated to a preset angle, the magnetic beads in the test cup 500 can just slide out along the wall of the test cup 500 at this time, thereby completing the entire bead removal of the test cup 500 process.

In an alternative embodiment, as shown in Figures 7, 12 and 13, the driving member 31 is an electric motor, the cup table 10 is provided with a connecting shaft 13 on the side opposite to the placing seat 11, and the driving member 31 The end of the output shaft 311 is connected to the connecting shaft 13. Specifically, the end of the connecting shaft 13 is provided with a connecting shaft through groove 131, the connecting shaft through groove 131 is located in the middle of the end surface of the connecting shaft 13, and the shape and size of the connecting shaft through groove 131 and the shape and size of the output shaft 311 Adaptation, in order to allow the driver 31 to better transmit the torque through the output shaft 311 to the placement seat 11, a fastening screw hole can be opened on the connecting shaft 13 through the connecting shaft through groove 131, and then through the fastening screw The connecting shaft 13 is locked on the connecting shaft through groove 131.

In an alternative embodiment, as shown in FIGS. 2, 7 to 13, the bracket 20 includes a bracket body 22 and a fixing bracket 21, wherein the fixing bracket 21 has an L-shaped structure, and its vertical end is connected to the bracket body 22. Connected, the horizontal end is installed on the unloading position 202 of the cup inlet groove 200 through the slide rail assembly 2021. The sliding rail assembly 2021 extends from the unloading position 202 of the cup inlet groove 200 to the test cup transfer mechanism 300. The bead removing device receives the test cup into the cup groove 200 and performs the bead removing operation. The slide rail assembly drives the bead removal device to move from the unloading position of the cup inlet groove 200 to the test cup transfer mechanism 300. The test cup transfer mechanism 300 takes out the test cup in the bead removing device and transfers it to the next process. The test cup transfer mechanism 300 may be a mechanical gripper or the like.

In this embodiment, the bracket body 22 is provided with a connecting shaft through hole 221, and the fixed bracket 21 is provided with a connecting shaft through hole 211. When the driving member 31 is installed on the bracket body 22, the output shaft 311 passes through the connecting shaft in turn. The through hole 211 and the connecting shaft through hole 221 are then connected to the connecting shaft through groove 131. In addition, in order to improve the bearing capacity of the output shaft 311 in the radial direction, a bearing can be sleeved on the output shaft 311 so that the inner ring of the bearing is connected to the output shaft 311, and the outer ring of the bearing is fixed on the connecting shaft through hole 221 .

In an alternative embodiment, as shown in FIGS. 6 to 8, the support 20 is also provided with a test cup table rotating groove 223 for accommodating the test cup table 10. The test cup table rotating groove 223 and the test cup table 10 Adapted, the test cup table 10 is placed in the test cup table rotating groove 223, and is rotatably connected to the test cup table rotating groove 223 through a connecting shaft. Specifically, the bottom of the rotating groove 223 of the test cup table is provided with a connecting shaft through hole 221 for the connecting shaft to penetrate. The test cup table 10 is fitted into the test cup table rotating groove 223, and is rotatably installed in the test cup table rotating groove 223 through a connecting shaft. After adopting the above technical solutions, not only the structure of the entire bead removing device 100 can be made more compact, but also the bearing capacity of the cup table 10 can be improved.

In an optional embodiment, as shown in FIGS. 4 to 8, the bead removing device 100 further includes a limiting mechanism for limiting the rotation angle of the cup table 10. Specifically, the limiting mechanism may be a control member installed on the driving member 31 to control the rotation angle of the output shaft 311; or the limiting mechanism may be a boss or a sliding groove provided in the connecting shaft through hole 221, and The sliding grooves or bosses on the output shaft 311 that match the bosses or sliding grooves are mainly used to control the rotation angle of the test cup table 10, to prevent the test cup 500 from falling off the test cup table 10, and to ensure the test cup After the magnetic beads in the table 10 are removed, the test cup table 10 can drive the test cup 500 to return to the original state where the test cup 500 is placed on the test cup table 10.

In this embodiment, as shown in Figures 7 to 12, the limiting mechanism includes: a limiting lug 121 arranged on the outside of the test cup table, and a first limiting lug provided in the rotating groove 223 of the test cup table of the bracket 20 A piece 2242 and a second limiting piece 2241. Wherein, the center angles corresponding to the stroke ranges of the first limiting member 2242 and the second limiting member 2241 are 100 to 150 degrees. It should be noted that the first limiting member 2242 and the second limiting member 2241 may be a boss provided on the bracket and other components that restrict the movement of the limiting lug 121. Specifically, the groove wall of the rotating groove 223 of the test cup table is provided with a limiting card slot 224, the first end wall of the limiting card slot 224 serves as the first limiting member 2242, and the limiting card slot 224 is connected to the first The second end wall opposite to the end wall serves as the second limiting member 2241, and the limiting lug 121 is movable between the first end wall and the second end wall. The center angle corresponding to the stroke between the first limiting member 2242 and the second limiting member 2241 of the limiting card slot 224 is 100 to 150 degrees. When the limiting lug 121 of the test cup stand 10 is located at the first limiting member 2242 of the limiting slot 224, the end surface of the placing seat 11 is parallel to the horizontal line, that is, the test cup of the test cup 500 is parallel to the horizontal line. When the limit lug 121 of the test cup table 10 rotates to the second limit member 2241 of the limit card slot 224, the test cup 500 on the placement seat 11 is tilted, so that the magnetic beads in the test cup 500 can follow the cup wall Slide out.

In an alternative embodiment, as shown in Figures 7 to 11, the cup table 10 includes a rotating table 12 in the shape of a round table, wherein the placement seat 11 is provided in the middle of the rotating table 12, and the upper side of the rotating table 12 is opened There is a gap 122, and the end surface formed by the gap 122 is flush with the upper end surface of the placement seat 11. Specifically, the length and width of the rotating table 12 are slightly larger than the length and width of the test cup. A gap 122 is provided on the rotating table 12, which not only facilitates the integration of the placement seat 11 and the rotating table 12, but also facilitates the positioning of the lugs. The forming process of 121, for example, is based on the end surface of the notch 122, and the limit lug 121 is set at a predetermined distance from the end surface of the notch 122. When the preset distance is just enough to make the rotating table 12 rotate to a certain angle, it is limited. The positioning lug 121 is in contact with the second limiting member 2241, and the magnetic beads in the test cup on the placing seat 11 can slide out along the cup wall of the test cup without causing the test cup to slide out of the placing seat 11.

In an alternative embodiment, as shown in FIG. 11, the placing seat 11 is provided with a placing groove 111, the width of the placing groove 111 is adapted to the width of the test cup, and the inner side and the two sides of the placing groove 111 The upper end is provided with a bevel chamfer 112, which not only enables the test cup to quickly enter the placing groove 111 through the bevel chamfer 112, but also ensures the relative position of the test cup and the placing groove 111.

In an alternative embodiment, as shown in FIGS. 4 to 10, the bracket body 22 is also provided with a ball row guide groove 222, and the ball row guide groove 222 is located on one side of the placing seat 11 and is used to guide the test cup The magnetic beads taken out in the process enter the magnetic bead storage device smoothly. Specifically, the bead row guide groove 222 is located on the lower left side of the rotating groove 223 of the test cup table (as shown in FIG. 10), and the limit card slot 224 is opened on the upper right side of the rotating groove 223 of the test cup table, which not only can fully support the limited body 22 Space, while ensuring the strong rigidity of the bracket body 22. In addition, it is also ensured that the magnetic beads can fall into the bead row guide groove 222 to facilitate the collection of the magnetic beads. For example, a magnetic bead storage device is provided under the bead row guide groove 222.

In an optional embodiment, the ball row guide groove 222 is in a concave arc shape toward the direction of the placement seat 11, and the center of the ball row guide groove 222 coincides with the rotation axis of the test cup table 10. Specifically, the diameter of the inner recess of the bead row guide groove 222 is approximately the same as the diameter formed by the rotation track of the outermost edge of the test cup, wherein the test cup is placed on the placement groove 111 and rotates with the test cup table 10; or The concave diameter of the guide groove 222 is slightly larger than the diameter of the arc that the outermost edge of the test cup rotates with the test cup table 10, which not only prevents the test cup from colliding with the outer wall of the bead guide groove 222 during the rotation, but also makes the test The outermost edge of the cup is attached to the concave edge of the bead row guide groove 222 and rotates to prevent the test cup from leaving the placing groove 111.

In an alternative embodiment, as shown in FIG. 9, a front baffle 2223 and two side baffles are provided on the ball row guide groove 222, and the two side baffles are respectively located on both sides of the ball row guide groove 222. The front baffle 2223 is connected to the front ends of the two side baffles, and makes the notch of the bead row guide groove 222 correspond to the cup opening of the test cup after rotating through the placing seat. Specifically, the two side baffles are respectively a left side plate 2221 and a right side plate 2222, wherein the left side plate 2221 is arranged on the left side of the bead guide groove 222, and the right side plate 2222 is arranged on the right side of the bead guide groove 222. On the side, the front baffle 2223 is connected to the left side plate 2221 and the right side plate 2222, so that the bead row guide groove 222 forms a closed groove with open ends at both ends, which plays a role of guiding the magnetic beads.

Embodiment 2 As shown in FIG. 14, the difference between this embodiment and Embodiment 1 lies in the bead removing mechanism 30, and the remaining parts are substantially the same. For example, the placement seat 11 can be directly fixed on the bracket. The bead removing mechanism 30 of this embodiment includes a magnetic rod 33 and a drive assembly 32, wherein the drive assembly 32 drives the magnetic rod 33 into the test cup 500 on the placement seat 11 and takes out the magnetic beads in the test cup 500. The structure is simple but practical.

Specifically, the bead removing mechanism 30 includes a transverse drive motor 34. The transverse drive motor 34 drives the magnet bar 33 to move laterally through the screw assembly 341. When the drive assembly 32 drives the magnet bar 33 to move in the direction of the test cup 500, the magnet bar 33 is attracted. Hold the magnetic beads of the test cup 500, and then the drive assembly 32 drives the magnetic rod 33 to move in the opposite direction of the test cup 500, and finally drives the motor 34 to drive the magnetic rod 33 away from the lateral direction of the test cup 500, and then stores the magnetic beads in the magnetic beads. In the storage device.

As shown in Figures 1 to 14, the present application also provides a method for removing magnetic beads from a test cup, including:

The controller obtains the test item and test method applied to the current test cup according to the predetermined test item and the corresponding test method of the test item. If the test method corresponding to the test item of the current test cup is not the magnetic bead test method, it outputs the bead removal operation instruction;

The bead removing mechanism 30 is connected to the operation instruction output terminal of the controller, and when the bead removing mechanism 30 receives the bead removing operation instruction, it will take out the magnetic beads in the test cup located in the placement seat 11 in the test cup table 10.

In the first embodiment, since the beading and beading mechanism 30 includes a driving part 31, which is an electric motor, the controller can be a PLC controller, a DSP controller, a single-chip microcomputer controller, and other commonly used controllers. . Specifically, when the test cup transportation system is started, the controller continuously reads the test item and the corresponding test method of the test item input by the user, and outputs the corresponding instruction according to the test item and the corresponding test method of the test item. Among them, the test items include coagulation analysis test items, and the corresponding test method of the test item can be the magnetic bead method or the optical method. The user can choose different test methods according to the needs.

Specifically, when the controller receives that the test method corresponding to the test item is the optical method, the controller generates a beading operation instruction and sends the beading operation instruction to the beading mechanism 30, and the beading mechanism 30 receives the beading operation When instructed, the driving member 31 in the bead removing mechanism 30 starts and drives the test cup table 10 to rotate. The test cup 500 rotates with the test cup table 10 (as shown in Figure 5). When the test cup table 10 rotates to a preset angle, the test cup The magnetic beads in 500 slide out along the wall of the test cup 500, and then the driving member 31 drives the test cup table 10 to rotate in the opposite direction to reset. After the bead removing mechanism 30 completes the entire bead removal process, the bead removing device 100 moves to unloading At 202, the test cup transfer mechanism 300 transfers the test cup 500 on the placement seat 11 to the next process, where the next process includes the addition of reagents.

In an optional embodiment, the controller obtains the test item and test method applied by the current test cup 500 according to the predetermined test item and the corresponding test method of the test item. If the test method of the current test cup 500 corresponding to the test item is magnetic In the bead test method, the bead retention operation instruction is output; when the bead removal mechanism 30 receives the bead retention operation instruction, the magnetic bead in the test cup 500 located in the placement seat 11 in the test cup table 10 is not taken out. It should be noted that, in addition to obtaining the test items and test methods of the current test cup application according to preset rules, the controller can also receive request instructions input by the user, and generate corresponding operation instructions according to the request instructions input by the user to control The beading mechanism 30 moves.

Specifically, when the controller receives that the test method corresponding to the test item is the magnetic bead method, the controller generates a bead retention operation instruction and sends the bead retention operation instruction to the bead removal mechanism 30, and the bead removal mechanism 30 receives the bead retention During the operation instruction, the loading device 400 transports the test cup 500 with magnetic beads to the placing base 11 through the loading position 201, and the bead removing device 100 does not perform any operation on the test cup 500, and directly moves to the unloading position 202, and the test cup is transferred. The mechanism 300 transfers the test cup 500 on the placement seat 11 to the next process, where the next process includes the addition of reagents.

In the first embodiment, when the bead removal mechanism 30 receives the bead removal operation instruction, the drive member 31 of the bead removal mechanism 30 drives the test cup table 10 to rotate and causes the test cup to tilt, so that the magnetic balls in the test cup 500 roll out. In the second embodiment, when the bead removal mechanism 30 receives the bead removal operation instruction, the drive assembly 32 of the bead removal mechanism 30 drives the magnetic rod 33 close to the test cup table 10 and extends into the test cup 500 so that the inside of the test cup 500 The magnetic beads are attracted by the magnetic rod 33, and the driving assembly 32 drives the magnetic rod 33 away from the test cup table 10, thereby completing the bead removal operation.

After adopting the above technical solution, since the existing test cup is stored in the cup-plate assembly, and the test cup contains magnetic beads, this not only causes interference to the optical measurement, but also increases the test cost accordingly. In this application, the cup and tray assembly can be directly placed on the feeding device 400, and the controller can generate bead removal operation instructions or bead retention operation instructions according to the test items input by the user and the test methods corresponding to the test items. The operation is simple and can reduce Test cost.

The above are only specific implementations of this application, but the protection scope of this application is not limited to this. Anyone familiar with the technical field can easily think of various equivalents within the technical scope disclosed in this application. Modifications or replacements, these modifications or replacements shall be covered within the protection scope of this application. Therefore, the protection scope of this application shall be subject to the protection scope of the claims.

Claims

A bead removing device, characterized in that it comprises:

Bracket

The test cup stand is installed on the bracket, and the test cup stand is provided with a placement seat for placing test cups;

The bead removing mechanism is installed on the bracket and used to take out the magnetic beads in the test cup on the placing seat.
The bead removing device according to claim 1, wherein the test cup table is rotatably mounted on the support, and the bead removing mechanism comprises:

The driving part, the output shaft of the driving part is in transmission connection with the test cup table, and is used to drive the test cup table to rotate, so that the test cup on the test cup table placement seat is in the output power of the driving part The lower part can rotate on a vertical plane relative to the bracket.
The bead removing device according to claim 2, wherein the driving member is an electric motor, the test cup table is provided with a connecting shaft on the side opposite to the placing seat, and the output shaft of the electric motor The end is connected with the connecting shaft.
The bead removing device according to claim 3, wherein the bracket is provided with a connecting shaft through hole, and the connecting shaft passes through the connecting shaft through hole.
The bead removing device according to claim 4, wherein the support is further provided with a test cup table rotating groove for accommodating the test cup table, the test cup table rotating groove and the test cup table Adapting, the test cup table is placed in the test cup table rotating groove, and is rotatably connected with the test cup table rotating groove through a connecting shaft.
The bead removing device according to claim 2, wherein the bead removing device further comprises a limiting mechanism for limiting the rotation angle of the test cup table.
The bead removing device according to claim 5, wherein the bead removing device further comprises a limit mechanism for limiting the rotation angle of the test cup table, and the limit mechanism comprises: The limiting lugs on the outer side of the test cup table, the first limiting member and the second limiting member provided in the rotating groove of the test cup table of the support; wherein, the first limiting member and the second limiting member The center angle corresponding to the stroke range of the two limit parts is 100-150 degrees.
The bead removing device according to claim 7, wherein the groove wall of the rotating groove of the test cup table is provided with a limiting card slot, and the first end wall of the limiting card slot serves as the first limiting member, and The second end wall of the limiting card slot opposite to the first end wall serves as a second limiting member, and the limiting lug is movable between the first end wall and the second end wall.
The bead removing device according to claim 2, wherein the test cup table includes a round table-shaped rotating table, the placement seat is arranged in the middle of the rotating table, and the upper side of the rotating table is provided with A gap, the end surface formed by the gap is flush with the upper end surface of the placement seat.
The bead removing device according to claim 1, wherein the placing seat is provided with a placing groove, the width of the placing groove is adapted to the width of the test cup, and the inside of both sides of the placing groove And the upper ends of both sides are provided with beveled chamfers, so that the test cup can enter the placing groove through the beveled chamfers.
The bead removing device according to claim 1, wherein the bracket is further provided with a row bead guide groove, and the end of the bead row guide groove corresponds to the magnetic bead inlet of the magnetic bead storage device to guide the The magnetic beads roll to the magnetic bead storage device.
The bead removing device according to claim 11, wherein the ball row guide groove is in a concave arc shape toward the placing seat, and the center of the ball row guide groove rotates with the test cup table. The axes coincide.
The bead removing device according to claim 11 or 12, wherein a front baffle plate and two side baffles are provided on the bead row guide groove, and the two side baffles are respectively located in the bead row guide On both sides of the groove, the front baffle plate is connected to the front ends of the two side baffle plates, and the notch of the ball row guide groove corresponds to the cup mouth of the test cup after rotating through the placing seat.
The bead removing device according to claim 1, wherein the bead removing mechanism comprises a magnetic rod and a driving assembly, and the driving assembly drives the magnetic rod into the test cup on the placement seat and drives the Remove the magnetic beads from the test cup.
A test cup transportation system is characterized in that it comprises:

The cup inlet groove includes a loading position and an unloading position. The loading position corresponds to the loading device to receive a test cup with magnetic beads conveyed by the loading device. The test cup in the cup inlet groove passes The unloading position performs unloading;

The bead removing device includes a bracket, a test cup table and a bead removing mechanism. The test cup table is installed on the bracket. The test cup table is provided with a placement seat for placing the test cup. The bead removing mechanism is installed in the The bracket is used to take out the magnetic beads in the test cup on the placement seat, the bracket can be movably installed on the unloading position of the cup inlet groove, and the placement seat and the upper cup inlet groove The material levels correspond to each other so that the test cup can enter the placement seat;

The test cup transfer mechanism transfers the test cup on the placing seat to the next process.
The test cup transportation system according to claim 15, wherein:

The test cup stand is rotatably mounted on the support, and the test cup on the test cup stand is rotated on a vertical plane relative to the support;

The bead removing mechanism includes a driving member, and an output shaft of the driving member is drivingly connected with the test cup table to drive the test cup to rotate.
The test cup transportation system according to claim 16, wherein the driving member is an electric motor, the test cup table is provided with a connecting shaft on the side opposite to the placing seat, and the bracket is provided with A connecting shaft through hole, and the connecting shaft is connected to the output shaft of the electric motor after passing through the connecting shaft through hole.
The test cup transportation system according to claim 17, wherein the support is also provided with a test cup table rotating groove for accommodating the test cup table, the test cup table rotating groove and the test cup The test cup table is adapted to the table, and the test cup table is placed in the rotating groove of the test cup table, and is rotatably connected with the rotating groove of the test cup table through a connecting shaft.
The test cup transportation system according to claim 16, wherein the bead removing device further comprises a limit mechanism for limiting the rotation angle of the test cup table.
The test cup transportation system according to claim 19, wherein the bead removing device further comprises a limit mechanism for limiting the rotation angle of the test cup table, and the limit mechanism includes: The limiting lugs on the outside of the test cup table, the first limiting member and the second limiting member provided in the rotating groove of the test cup table of the bracket; wherein, the first limiting member and the The center angle corresponding to the stroke range of the second limiter is 100-150 degrees.
The test cup transportation system according to claim 20, wherein the groove wall of the rotating groove of the test cup table is provided with a limited card slot, and the first end wall of the limit card slot is used as the first limiting member, so The second end wall of the limiting card slot opposite to the first end wall serves as a second limiting member, and the limiting lug is movable between the first end wall and the second end wall.
The test cup transportation system according to claim 15, wherein the test cup table comprises a rotating table in the shape of a round table, the placement seat is arranged in the middle of the rotating table, and the upper side of the rotating table is opened There is a gap, and the end surface formed by the gap is flush with the upper end surface of the placement seat.
The test cup transportation system according to claim 15, wherein the bracket is further provided with a ball row guide groove, the ball row guide groove is located on one side of the placement seat, and the ball row guide groove faces The direction of the placement seat is in a concave arc shape and is used to collect the magnetic beads taken out of the test cup.
The test cup transportation system according to claim 15, wherein the bead removing mechanism comprises a magnetic rod and a driving assembly, and the magnetic rod is inserted into the test cup on the placement seat through the driving assembly, Used to take out the magnetic beads in the test cup.
A method for removing magnetic beads from a test cup, which is characterized in that it comprises:

The controller obtains the test item and test method applied by the current test cup according to the predetermined test item and the corresponding test method of the test item. If the test method corresponding to the test item of the current test cup is not the magnetic bead test method, it outputs the bead removal operation instruction;

The bead removing mechanism is connected with the operation instruction output terminal of the controller, and when the bead removing mechanism receives the bead removing operation instruction, it will take out the magnetic beads in the test cup located in the seat in the test cup table.
The method for removing magnetic beads according to claim 25, further comprising:

The controller obtains the test item and test method applied by the current test cup according to the predetermined test item and the corresponding test method of the test item. If the test method of the current test cup corresponding to the test item is the magnetic bead test method, it outputs the bead retention operation instruction;

When the bead removing mechanism receives the bead-retaining operation instruction, it does not take out the magnetic beads in the test cup located in the seat in the test cup table.
The method for removing magnetic beads according to claim 25, wherein:

When the beading mechanism receives the beading operation instruction, the driving member of the beading mechanism drives the test cup table to rotate and causes the test cup to tilt, so that the magnetic balls in the test cup roll out.