CN104395760A - Cassette, and reagent set - Google Patents
Cassette, and reagent set Download PDFInfo
- Publication number
- CN104395760A CN104395760A CN201380030169.5A CN201380030169A CN104395760A CN 104395760 A CN104395760 A CN 104395760A CN 201380030169 A CN201380030169 A CN 201380030169A CN 104395760 A CN104395760 A CN 104395760A
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- reagent
- reagent container
- lower plate
- box
- upper plate
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/52—Containers specially adapted for storing or dispensing a reagent
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F29/00—Mixers with rotating receptacles
- B01F29/10—Mixers with rotating receptacles with receptacles rotated about two different axes, e.g. receptacles having planetary motion
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F29/00—Mixers with rotating receptacles
- B01F29/30—Mixing the contents of individual packages or containers, e.g. by rotating tins or bottles
- B01F29/32—Containers specially adapted for coupling to rotating frames or the like; Coupling means therefor
- B01F29/321—Containers specially adapted for coupling to rotating frames or the like; Coupling means therefor of test-tubes or the like
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N35/1002—Reagent dispensers
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/02—Adapting objects or devices to another
- B01L2200/025—Align devices or objects to ensure defined positions relative to each other
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0832—Geometry, shape and general structure cylindrical, tube shaped
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0848—Specific forms of parts of containers
- B01L2300/0858—Side walls
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
- G01N35/04—Details of the conveyor system
- G01N2035/0439—Rotary sample carriers, i.e. carousels
- G01N2035/0443—Rotary sample carriers, i.e. carousels for reagents
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
- G01N35/04—Details of the conveyor system
- G01N2035/0439—Rotary sample carriers, i.e. carousels
- G01N2035/0446—Combinations of the above
- G01N2035/0449—Combinations of the above using centrifugal transport of liquid
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- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Clinical Laboratory Science (AREA)
- Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
Abstract
A cassette having: a main body part (79) attached to a stirring device (16); and holding parts (56) which are formed on the main body part (79), hold reagent containers (26) in a non-extractable manner such that openings (27A) are exposed and the reagent containers (26) can rotate about the central axis thereof, and which enable connection members (94) for connecting the reagent containers (26) to the stirring device (16) to be attached to the bottom parts (27C) of the reagent containers (26).
Description
Technical field
The present invention relates to box and reagent kit.
Background technology
In clinical examination, usually adopt Radioimmunoassay of vascular endothelial growth, described Radioimmunoassay of vascular endothelial growth utilizes antigen-antibody reaction to measure the measured substance in a corpse or other object for laboratory examination and chemical testing.Specifically, in reaction vessel, add examination with insoluble carrier particle, Primary antibodies, mark secondary antibody and a corpse or other object for laboratory examination and chemical testing, examination with insoluble carrier particle forms the immunocomplex of Primary antibodies, measured substance and mark secondary antibody to measure the labelled amount in immunocomplex.As the immunoassay apparatus being used in this Radioimmunoassay of vascular endothelial growth, in Japanese Unexamined Patent Publication 2002-286726 publication, disclose a kind of immunoassay apparatus, accommodate the reagent containing examination with insoluble carrier particle reagent container, accommodate containing the reagent of Primary antibodies reagent container and accommodate containing mark secondary antibody reagent reagent container rotate worktable be provided with multiple described immunoassay apparatus.
Summary of the invention
The problem that invention will solve
But, at worktable, the plurality of reagents container cost time is set.In addition, when the position of placing reagent container is got wrong by user, the reagent of mistake is injected in reaction vessel, likely becomes and cannot carry out immunoassays accurately.
Problem of the present invention is, considers above-mentioned situation, suppresses the placement mistake of reagent container, and places reagent container at short notice.
For solving the means of problem
The box of a first aspect of the present invention has: main part, and it is installed on stirring apparatus; And maintaining part, described main part is formed multiple described maintaining part, reagent container to be held in the mode making the oral area of reagent container and expose and can not to extract and can rotate around the central shaft of reagent container by described maintaining part, and, can at the bottom mounting and connection parts of reagent container, reagent container and described stirring apparatus couple together by described link.
Box according to a first aspect of the invention, has the main part being installed on stirring apparatus, is formed with the multiple maintaining parts being held in by reagent container and can not extracting at this main part.Thus, from box, the situation of reagent container can not be taken out with making a mistake, reagent container can be suppressed to be positioned incorrectly in stirring apparatus.In addition, the mode exposed with oral area due to reagent container is held in box, therefore, as long as lid is opened the reagent that just can aspirate in reagent container.
Further, reagent container is held in and can rotates around central shaft by maintaining part, and, the link that reagent container and stirring apparatus can be coupled together is installed in the bottom of reagent container.Thus, stirring apparatus can make reagent container rotate by means of link, stir the reagent in reagent container.
The box of a second aspect of the present invention is the box according to first aspect, and described main part has: upper plate and lower plate, and their skies are opened and the compartment of terrain of reagent container can be kept to be configured; And connecting member, described upper plate and described lower plate link up by it, and described maintaining part has: upper hole, and it is formed at described upper plate, only makes the oral area of reagent container run through insertion; And lower opening, it is formed at described lower plate, the bottom of reagent container is run through and inserts and be supported to by reagent container and can rotate.
Box according to a second aspect of the invention, main part has the upper plate and lower plate that link up by means of connecting member, be formed in the upper hole of upper plate by making the oral area of reagent container run through to be inserted in, and the bottom of reagent container is run through be inserted in be formed in the lower circular hole of lower plate, thus reagent container is bearing between upper plate and lower plate in the mode that can rotate.Can not take out thereby, it is possible to utilize simple structure to be held in by reagent container and can rotate.
The box of a third aspect of the present invention is the box according to second aspect, and described connecting member is configured to comprise: upper plate leg, and it is projecting towards described lower plate from described upper plate; And snap-latch piece, it is formed at described upper plate, engages with described lower plate.
Box according to a third aspect of the invention we, is configured to comprise by the connecting member that upper plate and lower plate link up: upper plate leg, and it is projecting towards lower plate from upper plate; And snap-latch piece, it is formed at upper plate, engages with lower plate.Thus, by being remained between upper plate and lower plate by reagent container, and the snap-latch piece of upper plate is engaged with lower plate, thus reagent container can be made not take out.
The box of a fourth aspect of the present invention is the box according to second aspect or the third aspect, and described lower plate is provided with lower plate leg, utilizes described lower plate leg to form gap between described turntable and described lower plate.
Box according to a forth aspect of the invention, utilizes the lower plate leg being arranged at lower plate to form gap between turntable and lower plate.Thereby, it is possible to guarantee the space of the link coupled together in the bottom of reagent container and turntable.
The box of a fifth aspect of the present invention is that on described main part, be formed with holding section, described holding section engages with the jut arranged on the turning axle of the turntable of described stirring apparatus according to first aspect to the box of the either side in fourth aspect.
Reagent container box according to a fifth aspect of the invention, is formed with holding section at main part, and the jut that described holding section is arranged with the turning axle of the turntable at stirring apparatus engages.Thereby, it is possible to easily main part to be positioned the turning axle of turntable.
The reagent kit of a sixth aspect of the present invention has: the box described in first aspect to the either side in the 5th aspect; With multiple reagent container, the multiple described maintaining part that they are formed on described box is held in and can not extracts.
Reagent kit according to a sixth aspect of the invention, multiple maintaining parts that reagent container is formed on box are held in and can not extract.Thus, the situation that the position that reagent container can not occur is changed, can be delivered to the inspection bodies such as hospital as former state by the box being placed with reagent container in factory.
The reagent kit of a seventh aspect of the present invention is the reagent kit according to the 6th aspect, be held in by multiple described maintaining part in the multiple described reagent container that can not extract, reagent container described at least one is connected with described stirring apparatus through described link.
Reagent kit according to a seventh aspect of the invention, in the reagent container that maintained portion keeps, at least one reagent container is connected with stirring apparatus through link.Thus, be stirred by means of stirring apparatus under the state being held in box at reagent container.
The reagent kit of a eighth aspect of the present invention is the reagent kit according to the 7th aspect, accommodates the reagent containing examination with insoluble carrier particle in the reagent container be connected with described stirring apparatus through described link.
Reagent kit according to an eighth aspect of the invention, accommodates the reagent containing examination with insoluble carrier particle in the reagent container be connected with stirring apparatus through link.Because reagent container is connected with stirring apparatus by means of link, therefore, it is possible to utilize stirring apparatus and make the reagent containing examination with insoluble carrier particle be contained in reagent container be stirred, examination with insoluble carrier particle can be suppressed to precipitate.
The reagent kit of a ninth aspect of the present invention is the reagent kit according to eighth aspect, and the reagent containing examination with insoluble carrier particle is the reagent containing magnetic carrier particle.
Reagent kit according to a ninth aspect of the invention, can suppress the magnetic carrier particle as heavy examination with insoluble carrier particle to precipitate.
Invention effect
Because the present invention forms above-mentioned structure, therefore, it is possible to suppress the placement mistake of reagent container, and reagent container can be placed at short notice.
Accompanying drawing explanation
Fig. 1 is the vertical view of the basic structure that the immunoassay apparatus possessing turntable is shown, described turntable is placed with the reagent kit of the first embodiment.
Fig. 2 is the exploded perspective view of the reagent kit that the first embodiment is shown.
Fig. 3 is the stereographic map at the back side of the lower plate of the box that the first embodiment is shown.
Fig. 4 is the vertical view of the partial cutoff of the turntable that the reagent kit being placed with the first embodiment is shown.
Fig. 5 is the schematic diagram for illustration of the reagent container of the box being held in the first embodiment and the connecting portion of turntable.
Fig. 6 is the stereographic map that the state sucked by reagent from the reagent container of the box being held in the first embodiment is shown.
Fig. 7 is the stereographic map of the box that the second embodiment is shown.
Embodiment
(the first embodiment)
< one-piece construction >
With reference to accompanying drawing, the immunoassay apparatus 200 with stirring apparatus 16 is described, in described stirring apparatus 16, is placed with the reagent kit 11 comprising box 10 of the first embodiment of the present invention.As shown in Figure 1, immunoassay apparatus 200 is configured to mainly comprise chamber feed unit 14, reagent Keeping Unit 12, reaction bench 18, corpse or other object for laboratory examination and chemical testing platform 20, BF (Bind/Free: combination/free) unit 22 and determination unit 24.In addition, in the following description, for convenience of description, be nearby described side using corpse or other object for laboratory examination and chemical testing platform 20 side as device.
The chamber feed unit 14 being configured in the left inboard of immunoassay apparatus 200 chamber of sky (reaction vessel) is transported to the position of regulation and makes it be arranged in the unit of row.Chamber feed unit 14 is configured to comprise chamber groove 30, track 32 and chamber transport mechanism 34.Be configured with reagent Keeping Unit 12 at the nearby place of chamber feed unit 14, described reagent Keeping Unit 12 accommodates the stirring apparatus 16 possessing turntable 36.In the box 10 being positioned over turntable 36, maintain multiple reagent container 26A, 26B, 26C, in described multiple reagent container 26A, 26B, 26C, accommodate the reagent (with reference to Fig. 2) needed for immunoassays.In addition, reagent Keeping Unit 12 is cooled to certain temperature by cooling unit (not shown).
Reaction bench 18 is configured with on the right side of reagent Keeping Unit 12.Reaction bench 18 is positioned at central portion than immunoassay apparatus 200 slightly by left side, possesses well heater (not shown).In addition, at the peripheral part of reaction bench 18, the recess 38 keeping chamber is formed in the complete cycle scope of reaction bench 18.In the present embodiment, the circumference as an example along reaction bench 18 is equally spaced formed with 60 recesses 38.In addition, well heater (not shown) can be utilized to heat the chamber be held in recess 38, make the agent of activity in chamber.
Corpse or other object for laboratory examination and chemical testing platform 20 is configured with at the nearby place of reaction bench 18.The multiple test tubes 40 accommodating a corpse or other object for laboratory examination and chemical testing are maintained at corpse or other object for laboratory examination and chemical testing platform 20.In addition, BF unit 22 is configured with on the right side of reaction bench 18 across chamber handle 72 described later.BF unit 22 is configured to comprise: BF platform 42, and it rotates transfer chamber; With BF nozzle unit 44, it carries out B/F separation to the reagent be positioned in the chamber of BF platform 42.In addition, in the present embodiment, the inboard of device and nearby this two place, side be configured with BF unit 22, but also can only be configured in a place.
Determination unit 24 is configured with across chamber handle 74 described later on the right side of BF unit 22.Determination unit 24 is configured to comprise: mixing part 46, and it stirs the reagent in chamber; With measuring cell 48, it measures light quantity.
In immunoassay apparatus 200, except above-mentioned parts, be also configured with: chamber handle 52, it makes chamber move to reaction bench 18; And reagent dispensing nozzle 54 and reagent dispensing nozzle 68, it is by reagent suction and discharge.In addition, the sample dispensing nozzle 60 by corpse or other object for laboratory examination and chemical testing suction and discharge is configured with.Further, the unit, the chamber handle that form immunoassay apparatus 200 are connected with control part (not shown) with nozzle etc., and the action according to the signal from control part.
< immunoassay >
Below, an example of the immunoassay adopting immunoassay apparatus 200 is described.In addition, in the present embodiment, adopt containing the reagent of streptavidin in conjunction with magnetic carrier particle as the reagent containing examination with insoluble carrier particle, but be not limited thereto, also can adopt the reagent containing other magnetic carrier particle.In addition, when not adopting magnet to carry out B/F separation, the not magnetic examination with insoluble carrier particle of tool, such as latex etc. can be adopted.In the present embodiment, adopt the reagent containing biotinylation Primary antibodies as the reagent containing Primary antibodies, but be not limited thereto, the reagent of the antibody suitably selected containing the kind of the with good grounds reagent containing examination with insoluble carrier particle can be adopted.In the present embodiment, the reagent containing alkali phosphatase enzyme mark secondary antibody is adopted as the reagent containing mark secondary antibody, but be not limited thereto, can adopt the reagent containing the antibody utilizing mark substance to mark, described mark substance is suitably selected according to the kind of measured substance.In the present embodiment, have employed the chemiluminescent immunoassay based on sandwich method as immunoassay, but be not limited thereto, also can adopt other immunoassay.
First, multiple untapped chamber is put in the chamber groove 30 of chamber feed unit 14 by user.In addition, the chamber (also referred to as cuvette) used in present embodiment one open-endedly plasticly has round-ended cylinder body, and be the reaction vessel that peristome is formed with flange.
The chamber put in chamber groove 30 is lifting the top that machine (not shown) is one by one lifted to chamber groove 30, then, the track 32 that the bar tilted is formed slides and be transported to chamber transport mechanism 34 by two.
Carry out opening and closing by the arrangement board 50 of chamber transport mechanism 34, thus the chamber being transported to chamber transport mechanism 34 is one by one sent to the terminal part 32A of track 32.In addition, also chamber transport mechanism 34 can not be set and make chamber slide into the terminal part 32A of track 32 from chamber groove 30.
The chamber arriving the terminal part 32A of track 32 is held by chamber handle 52, and is placed to rotatably in the recess 38 of reaction bench 18 around turning axle 52A.Then, be transported to immediately below reagent dispensing nozzle 54 by the rotation of reaction bench 18.Here, reagent dispensing nozzle 54 rotates around turning axle 54A, from the reagent container 26A being held in box 10, suction is discharged in chamber containing streptavidin in conjunction with the reagent of magnetic carrier particle, and described box 10 is placed on turntable 36 (with reference to Fig. 6).
Then, from other reagent container 26B, suction is discharged in chamber containing the reagent of biotinylation Primary antibodies.Here, discharge and cleaned for the time being in dispensing nozzle cleaning groove 58 containing the reagent dispensing nozzle 54 of streptavidin in conjunction with the reagent of magnetic carrier particle, then, carry out the suction of the reagent containing biotinylation Primary antibodies.Thereby, it is possible to prevent reagent to be mixed into.
Made discharge contain streptavidin in conjunction with the reagent of magnetic carrier particle be transported near sample dispensing nozzle 60 containing the chamber of reagent of biotinylation Primary antibodies by the rotation of reaction bench 18, the well heater being simultaneously arranged at reaction bench 18 is heated to the temperature of regulation (in the present embodiment, 37 DEG C as an example), promote the reaction of streptavidin and the biotin antibody be combined with magnetic carrier particle.
When chamber is transported to after near sample dispensing nozzle 60, sample dispensing nozzle 60 rotates around turning axle 60A, aspirates a corpse or other object for laboratory examination and chemical testing and be discharged in the chamber of discharging and containing the reagent of streptavidin in conjunction with magnetic carrier particle and the reagent containing biotinylation Primary antibodies from the test tube 40 being positioned over corpse or other object for laboratory examination and chemical testing platform 20.In addition, when adopt dilution in mensuration, sample dispensing nozzle 60 rotates around turning axle 60A, and from diluent container 64 sucking dilution liquid.Then, from the test tube 40 being positioned over corpse or other object for laboratory examination and chemical testing platform 20, aspirate a corpse or other object for laboratory examination and chemical testing, a corpse or other object for laboratory examination and chemical testing and the potpourri of dilution are discharged in the chamber of discharging and containing the reagent of streptavidin in conjunction with magnetic carrier particle and the reagent containing biotinylation Primary antibodies.Then, the sample dispensing nozzle 60 that the potpourri of a corpse or other object for laboratory examination and chemical testing or a corpse or other object for laboratory examination and chemical testing and dilution is discharged in chamber is cleaned in corpse or other object for laboratory examination and chemical testing nozzle cleaning groove 62.Thereby, it is possible to prevent the pollution that the corpse or other object for laboratory examination and chemical testing in sample dispensing nozzle 60 causes.
The position of the rabbling mechanism 66 that the chamber of a discharge corpse or other object for laboratory examination and chemical testing or a corpse or other object for laboratory examination and chemical testing and dilution is transported to the periphery along reaction bench 18 and arranges, utilizes rabbling mechanism 66 and stirs the reagent in chamber, a corpse or other object for laboratory examination and chemical testing and dilution in a non-contact manner.The bottom of chamber is stirred rotatably by the track of conical pendu0, but is not limited thereto, also can hold chamber to shake.In addition, be not limited to contactless stirring, also puddler can be put in chamber and directly stir.In this case, in order to preventing pollution, need to clean puddler after stirring.
Thus, the measured substance in a corpse or other object for laboratory examination and chemical testing is combined with Primary antibodies, and magnetic carrier particle is formed the complex of Primary antibodies and measured substance.Then, reagent dispensing nozzle 68 rotates around turning axle 68A, from be held in reagent Keeping Unit 12 box 10 assigned position reagent container 26C aspirate alkali phosphatase enzyme mark secondary antibody and be discharged in chamber.Reagent dispensing nozzle 68 moves to dispensing nozzle cleaning groove 70 and cleans after alkali phosphatase enzyme mark secondary antibody being discharged.
Reagent class in the chamber of discharge alkali phosphatase enzyme mark secondary antibody is stirred mechanism 66 and stirs, and promotes the reaction of the measured substance in alkali phosphatase enzyme mark secondary antibody and a corpse or other object for laboratory examination and chemical testing.Thus, magnetic carrier particle is formed the complex (immunocomplex) be made up of Primary antibodies, measured substance and alkali phosphatase enzyme mark secondary antibody.
Then, make chamber be transported near chamber handle 72 by the rotation of reaction bench 18, and held by chamber handle 72, be transported to a BF unit 22 rotatably around turning axle 72A.The chamber being transported to BF unit 22 is placed in the recess 42A of the peripheral part being arranged on BF platform 42.Here, in the inside of BF platform 42, the outer peripheral face of chamber is provided with neodium magnet (not shown), collection magnetic is carried out to the magnetic carrier particle in the chamber be placed in recess 38.
Then, BF nozzle unit 44 moves to the top of the chamber be placed in recess 42A.Further, the four BF nozzle 44A forming BF nozzle unit 44 carry out the unreacted suction of reagent class and the discharge of cleaning fluid to the chamber be placed in each recess 42A.Now, collect magnetic do not aspirated by BF nozzle 44A in the magnetic carrier particle of neodium magnet and the immunocomplex that is combined with magnetic carrier particle and remain in chamber.
On the other hand, the reagent class be not combined with magnetic carrier particle is aspirated by BF nozzle 44A and removes from chamber.Like this, the material (Bind: combine) combined with magnetic carrier particle and unconjugated material (Free: freely) separated (B/F is separated).In addition, in the present embodiment, repeat B/F and be separated, reliably the reagent class be not combined with magnetic carrier particle is removed.
The chamber having carried out B/F separation is held by chamber handle 74, is transported to the mixing part 46 of determination unit 24 around turning axle 74A rotatably.Now, detect reagent (luminous host reagent) to be discharged in chamber from the pipe (not shown) being arranged at chamber handle 74.In mixing part 46, immunocomplex and luminous host reagent are stirred, the alkaline phosphatase in immunocomplex and luminous host reagent reacting and luminous.
Then, chamber is held by chamber handle 74 and is transported to rotatably in measuring cell 48 around turning axle 74A.Measuring cell 48 for completely by inaccessible and do not enter the space of light, measures the reaction due to the alkaline phosphatase in immunocomplex and luminous host reagent and the luminous quantity of light that produces in measuring cell 48.The concentration of the measured substance in a corpse or other object for laboratory examination and chemical testing is determined according to the luminous quantity of this mensuration.Measure complete chamber held by chamber handle 74 and be thrown in discarded pipe 76.The concentration of the measured substance in a corpse or other object for laboratory examination and chemical testing is accumulated as data by control part, and makes monitor (not shown) etc. demonstrate measurement result.
The structure > of < reagent kit
Below, the structure of the reagent kit 11 of present embodiment is described.As shown in Figure 2, reagent kit 11 has box 10 and is held in three reagent containers 26A, 26B, 26C of box 10.In addition, in the following description, reagent container 26 is only labeled as when not distinguishing especially.
During top view, box 10 is resin components of the roughly triangular shape of bight X, Y, the Z with three places, and it has main part 79.Main part 79 is configured to mainly comprise upper plate 78, lower plate 80, snap-latch piece 82 and upper plate leg 78B.Upper plate 78 is positioned at the top of main part 79, is formed along the through upper circular hole 84 as three upper holes of thickness direction.
Three upper circular holes 84 are formed near bight X, Y, Z of upper plate 78 respectively, form maintaining part 56 with the lower circular hole 88 of lower plate 80 described later.In the present embodiment, be formed with three of same diameter upper circular holes 84, but be not limited thereto, also can form the upper circular hole 84 of different-diameter accordingly with the size of the reagent container 26 kept.In addition, the upper circular hole 84 of more than four can also be formed.
The upper plate leg 78B extended to lower plate 80 is formed respectively at X, Y, Z place, bight of upper plate 78.In addition, at the peripheral end of upper plate 78, between upper plate leg 78B, be formed with periphery flange 78A, improve the rigidity of upper plate 78.Further, the upper groove portion 86 of the groove gap shape that upper plate leg 78B is caved in the inner side of upper plate 78 is formed at the X place, bight of upper plate 78.
In the end with opposition side, upper groove portion 86, between the bight Y and bight Z of upper plate 78, be formed with snap-latch piece 82.Snap-latch piece 82 is configured to comprise: rectangular-shaped dull and stereotyped 82A, and it extends from periphery flange 78A to lower plate 80, forms the length roughly the same with upper plate leg 78B; With claw 82B, it is formed at the end central portion of dull and stereotyped 82A.In addition, in the present embodiment, upper plate 78 and snap-latch piece 82 form as one, but also can be formed as split.
The pin 87 extended along short transverse is installed at the bight Y of upper plate 78 and Z place, bight.Pin 87 is elongated cylindrical members, and the back side of upper plate 78 is fixed in the upper end of pin 87, is formed with diameter is less than pin 87, columned location division 87A in the bottom of pin 87.In addition, be formed at the X place, bight of upper plate 78 from two outstanding downwards juts 89 of the bottom of upper plate leg 78B.
Identical with upper plate 78, lower plate 80 is roughly triangular shape, is formed along the through lower circular hole 88 as lower opening of thickness direction.Lower circular hole 88 is formed as with upper circular hole 84 same shape and coaxial with upper circular hole 84.
Be formed with the lower plate leg 80B extended at X, Y, Z place, bight of lower plate 80 respectively downwards, at the peripheral end of lower plate 80, between lower plate leg 80B, be formed with periphery flange 80A.Periphery flange 80A is formed as being shorter in length than lower plate leg 80B.In addition, the subsidiary region 80C (with reference to Fig. 3) with the paster of lower plate leg 80B equal length is formed in the side of a side (inboard in figure) of periphery flange 80A.The subsidiary region 80C of paster is the position of subsidiary paster, described paster records the information of the reagent in reagent container 26 and lot number etc.
Be formed with the lower groove portion 90 with upper groove portion 86 same shape at the X place, bight of lower plate 80, upper groove portion 86 and lower groove portion 90 form holding section, and described holding section engages with the rib 96A as jut of the turning axle 96 being arranged at turntable 36 (with reference to Fig. 4).
As shown in Figure 3, in the end with opposition side, lower groove portion 90, be formed with engaged part 80D between bight Y and bight Z, described engaged part 80D is for the claw 82B hook of snap-latch piece 82.The lower plate 80 that is formed as engaged part 80D making caves in the amount suitable with the thickness of snap-latch piece 82 to the inside, is configured to maintain the state that claw 82B engages.
Near bight X, Y, Z of lower plate 80, be formed with pin 92, described pin 92 extends downwards from the back side of lower plate 80.Pin 92 is elongated cylinder parts, is formed with tapering portion 92A in the bottom of pin 92, described tapering portion 92A extend to than lower plate leg 80B bottom on the lower.Here, when box 10 is installed on stirring apparatus 16, tapering portion 92A is embedded in recess 98, and described recess 98 is formed at the turntable 36 (with reference to Fig. 4) of stirring apparatus 16.
As shown in Figure 2, be formed with recess 91 in the upper end of pin 92, described recess 91 caves in downwards from the upper surface of lower plate 80 and supplies the location division 87A of the pin 87 being formed at upper plate 78 to insert.In addition, be formed with recess 93 at the upper surface of the bight X of lower plate 80, described recess 93 inserts for the jut 89 of upper plate 78.
Three reagent containers 26A, 26B, 26C are maintained in space between the upper plate 78 arranged utilizing the upper plate leg 78B of upper plate 78 and lower plate 80.Reagent container 26 is that the resinous of upper end open has bottom tube-like parts respectively, is formed by injection mo(u)lding etc.In addition, reagent container 26 has container body 27, and described container body 27 is formed by with lower part: oral area 27A, and it has the external thread part tightened for lid 28; Large-diameter portion 27B, it is formed at the bottom of oral area 27A; With bottom 27C, it is formed at the bottom of large-diameter portion 27B.Further, at the bottom 27C of the container body 27 of reagent container 26A, the cylinder 94 as link is installed.In the upper inside wall of cylinder 94, be formed in two places, in the bottom of cylinder 94, the notch part 94B caved in upward is formed in two places opposedly opposedly with the jut 94A that the recess 27D of the bottom 27C being formed at container body 27 engages.
Here, in order to make reagent container 26 be held in main part 79, first, the bottom 27C of container body 27 is run through and is inserted in the lower circular hole 88 of lower plate 80.Thus, container body 27 can be supported in lower circular hole 88 rotatably.Now, the reagent container 26A accommodated containing the reagent of examination with insoluble carrier particle is run through in the lower circular hole 88 of the X side, bight being inserted in lower plate 80.
Then, from the top of reagent container 26, upper plate 78 is installed on lower plate 80.Now, the recess 91 of the location division 87A and lower plate 80 that are formed at the pin 87 of upper plate 78 engages, and the recess 93 of the jut 89 and lower plate 80 that are formed at the bight X of upper plate 78 engages, and upper plate 78 and lower plate 80 are located.
In addition, the claw 82B of snap-latch piece 82 is hooked in engaged part 80D, is fixed into upper plate 78 and can not be separated with lower plate 80.Now, the oral area 27A of container body 27 runs through outstanding from the upper surface of upper plate 78 in the upper circular hole 84 being inserted in upper plate 78.
In this condition, the large-diameter portion 27B of container body 27 is retained and can rotates between lower plate 80 and upper plate 78, becomes and can not extract from box 10.Then, lid 28 is installed on tightening the oral area 27A of container body 27.In addition, when the external diameter of lid 28 is less than circular hole 84, also before upper plate 78 is installed on lower plate 80, in advance lid 28 can be installed on reagent container 26.
In addition, in the present embodiment, circular upper circular hole 84 and lower circular hole 88 is formed at upper plate 78 and lower plate 80, but be not limited thereto, as long as be formed as reagent container 26 to be held in the shape that can rotate, such as, also can be the hole of rectangle etc., in addition, also can be polygon-shaped hole.
The structure > of < stirring apparatus
Below, the structure of the stirring apparatus 16 being placed with reagent kit 11 is described.As shown in Figure 4, the stirring apparatus 16 of present embodiment has the turntable 36 that can rotate.Be circular sheet material when turntable 36 is top view, 10 reagent kits 11 can be placed.At the center of turntable 36, turning axle 96 runs through (paper the is side nearby) extension upward of turntable 36 ground, at the peripheral part of turning axle 96, is equally spaced radially extruded with 10 rib 96A as jut around turning axle 96.
10 through holes 100 are formed with around turning axle 96 ground between the peripheral part and central portion of turntable 36.Through hole 100 is formed at the position corresponding with the upper circular hole 84 of the X side, bight of reagent kit 11 and lower circular hole 88 when reagent kit 11 being positioned over turntable 36, and the center of this through hole 100 is provided with columned turning axle 102.
Turning axle 102 is outstanding a little from the upper surface of turntable 36, is provided with rotor 104 at the end face of turning axle 102.As shown in Figure 5, rotor 104 is parts that length is longer than the tabular in the aperture of through hole 100, and the central part of the upper end of rotor 104 becomes the bend 104A hollowing out into arc-shaped.
Here, as shown in Figure 4, in the rear side of turntable 36, gear 106 and turning axle 96 are fixed on the base portion (not shown) of stirring apparatus 16 coaxially.In addition, turning axle 96 runs through through bearing (not shown) and is inserted in gear 106.Further, the turning axle 102 being provided with rotor 104 runs through in the multiple planet wheels 108 being inserted in and engaging with gear 106.Therefore, turning axle 102 and planet wheel 108 rotate integratedly.Here, when driver element makes turntable 36 rotate to arrow A direction, planet wheel 108 along gear 106 periphery and engage with gear 106 while rotate to identical sense of rotation (arrow B direction).Thus, rotor 104 rotates to arrow B direction similarly.In addition, also can form like this: make gear 106 be directly fixed on turning axle 96 without bearing, the sense of rotation of gear 106 and the sense of rotation changeabout direction of rotor 104.
Be formed with the recess 98 of multiple circle at the peripheral end of turntable 36, be also formed with same recess 98 than through hole 100 by radial center side.Here, when reagent kit 11 is positioned over turntable 36, first, relative to the turning axle 96 of turntable 36 rib 96A and the upper groove portion 86 of main part 79 and lower groove portion 90 are inserted.Then, the pin 92 of the lower plate 80 being formed at box 10 is inserted in recess 98, thus carries out the location of reagent kit 11.
In addition, as shown in Figure 5, the notch part 94B being installed on the cylinder 94 of reagent container 26A is inserted into rotor 104.Here, owing to being formed with bend 104A at rotor 104, therefore, even if be inserted in notch part 94B by rotor 104, reagent container 26A also can not suffer oppression.In addition, even if when notch part 94B is not inserted in rotor 104, because rotor 104 rotates, thus notch part 94B is inserted into rotor 104, and reagent container 26A is placed on through hole 100, does not therefore have improper.
< effect >
Below, the box 10 of present embodiment and the effect of reagent kit 11 are described.As shown in Figure 2, because reagent container 26 is maintained in the space between upper plate 78 and lower plate 80 in the mode that can not extract, therefore, user cannot change the position of reagent container 26, can suppress the placement mistake of reagent container 26.
In addition, as long as just three reagent containers 26 once can be placed owing to reagent kit 11 to be positioned over turntable 36, therefore, compared with reagent container 26 being positioned over individually the situation of turntable 36, in short time and easily reagent container 26 can be placed.
Further, after reagent kit 11 is positioned over turntable 36, unload by means of only by the lid 28 of reagent container 26, the oral area 26A of reagent container 26 will expose, and can aspirate reagent.Such as, as shown in figures 1 to 6, when utilizing reagent dispensing nozzle 54 to aspirate the reagent in reagent container 26, reagent dispensing nozzle 54 can be made to move to the top of the reagent container 26 that lid 28 is removed, by means of only making the spray nozzle part 110 of reagent dispensing nozzle 54 decline, the reagent in reagent container 26 just can be aspirated.In addition, because in the space between periphery flange 78A and lower plate 80, the large-diameter portion 27B of reagent container 26 exposes, therefore, it is possible to easily lid 28 is unloaded.
Here, owing to accommodating the reagent containing not capacitive carrier particle in the reagent container 26A of X side, bight being held in box 10, therefore need to stir, avoid examination with insoluble carrier particle to precipitate.Reagent kit 11 according to the present embodiment, if box 10 is positioned over turntable 36, then the cylinder 94 at 27C place, bottom and the rotor 104 of turntable 36 that are installed in the reagent container 26A of the reagent accommodated containing examination with insoluble carrier particle are connected.Therefore, as shown in Figure 4, as long as make turntable 36 rotate (revolution), rotor 104 will rotate and reagent container 26 be rotated (rotation).Therefore, do not adopt special stirring apparatus just can stir examination with insoluble carrier particle, examination with insoluble carrier particle can be suppressed to precipitate.Particularly, when adopting heavy magnetic carrier particle as examination with insoluble carrier particle, magnetic carrier particle can be suppressed to precipitate, and can stir magnetic carrier particle equably, be therefore preferred.
(the second embodiment)
Below, the box 120 of the formation reagent kit of the second embodiment is described.In addition, the label identical to the structure mark same with the first embodiment, omits the description.As shown in Figure 7, box 120 is configured to the snap-latch piece 126 that comprises upper plate 122, lower plate 124 and upper plate 122 and lower plate 124 are linked up.
During top view, upper plate 122 and lower plate 124 are elongated rectangle, and an end of length direction is formed as the tapered taper towards end.In addition, be linearly formed with circular hole 128 on three at upper plate 122, be also formed with lower circular hole 130 in same position in lower plate 124.
Box 120 according to the present embodiment, because width is formed be narrower than the box 10 of the first embodiment, therefore, it is possible to place more box 120 along the circumference of turntable.In addition, because upper circular hole 128 and lower circular hole 130 form linearity, therefore, it is possible to the radial outside of planet wheel 108 in such as Fig. 4 arranges other planet wheel and makes to be engaged with each other.Thus, even when multiple reagent container 26 accommodated containing the reagent of examination with insoluble carrier particle being held in box 120 in Fig. 7, also can stir the reagent in multiple reagent container 26.
Above the first embodiment of the present invention and the second embodiment are illustrated, but the invention is not restricted to such embodiment, both can combine embodiment use, can certainly be implemented by various mode without departing from the scope of the subject in the invention.Such as, as long as the cylinder 94 being installed in the 27C place, bottom of reagent container 26A in Fig. 2 can be installed on the shape of the bottom 27C of reagent container 26A, then also can be arbitrary shape, such as, also can be square tube.
Label declaration
10 boxes
11 reagent kits
16 stirring apparatuss
26 reagent containers
27A oral area
Bottom 27C
36 turntables
56 maintaining parts
78 upper plates
78B upper plate leg (connecting member)
79 main parts
80 lower plates
80B lower plate leg
82 snap-latch pieces (connecting member)
Circular hole (upper hole) on 84
On 86 groove portion (holding section)
88 times circular holes (lower opening)
90 times groove portions (holding section)
94 cylinders (link)
96 turning axles
96A rib (jut)
120 boxes
122 upper plates
124 lower plates
126 snap-latch pieces (connecting member)
Circular hole (upper hole) on 128
130 times circular holes (lower opening)
Claims (9)
1. a box, this box has:
Main part, it is installed on stirring apparatus; And
Maintaining part, described main part is formed multiple described maintaining part, reagent container to be held in the mode making the oral area of reagent container and expose and can not to extract and can rotate around the central shaft of reagent container by described maintaining part, and, can at the bottom mounting and connection parts of reagent container, reagent container and described stirring apparatus couple together by described link.
2. box according to claim 1, wherein,
Described main part has: upper plate and lower plate, and their skies are opened and the compartment of terrain of reagent container can be kept to be configured; And connecting member, described upper plate and described lower plate link up by it,
Described maintaining part has: upper hole, and it is formed at described upper plate, only makes the oral area of reagent container run through insertion; And lower opening, it is formed at described lower plate, the bottom of reagent container is run through and inserts and be supported to by reagent container and can rotate.
3. box according to claim 2, wherein,
Described connecting member is configured to comprise: upper plate leg, and it is projecting towards described lower plate from described upper plate; And snap-latch piece, it is formed at described upper plate, engages with described lower plate.
4. the box according to Claims 2 or 3, wherein,
Described lower plate is provided with lower plate leg, utilizes described lower plate leg and form gap between described turntable and described lower plate.
5. the box according to any one in Claims 1-4, wherein,
Described main part is formed with holding section, and described holding section engages with the jut arranged on the turning axle of the turntable of described stirring apparatus.
6. a reagent kit, it has:
Box described in any one in claim 1 to 5; With
Multiple reagent container, the multiple described maintaining part that they are formed on described box is held in and can not extracts.
7. reagent kit according to claim 6, wherein,
Be held in by multiple described maintaining part in the multiple described reagent container that can not extract, reagent container described at least one is connected with described stirring apparatus through described link.
8. reagent kit according to claim 7, wherein,
The reagent containing examination with insoluble carrier particle is accommodated in the reagent container be connected with described stirring apparatus through described link.
9. reagent kit according to claim 8, wherein,
Reagent containing examination with insoluble carrier particle is the reagent containing magnetic carrier particle.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JPJP2012-142147 | 2012-06-25 | ||
| JP2012142147 | 2012-06-25 | ||
| JP2012-142147 | 2012-06-25 | ||
| PCT/JP2013/067259 WO2014002952A1 (en) | 2012-06-25 | 2013-06-24 | Cassette, and reagent set |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN104395760A true CN104395760A (en) | 2015-03-04 |
| CN104395760B CN104395760B (en) | 2016-08-24 |
Family
ID=49783098
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201380030169.5A Expired - Fee Related CN104395760B (en) | 2012-06-25 | 2013-06-24 | Box and reagent kit |
Country Status (3)
| Country | Link |
|---|---|
| JP (1) | JP6012728B2 (en) |
| CN (1) | CN104395760B (en) |
| WO (1) | WO2014002952A1 (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107037226A (en) * | 2015-11-13 | 2017-08-11 | 古野电气株式会社 | Analytical equipment |
| CN107044922A (en) * | 2017-01-20 | 2017-08-15 | 广东顺德工业设计研究院(广东顺德创新设计研究院) | Sampler |
| CN111630394A (en) * | 2018-01-25 | 2020-09-04 | 希森美康株式会社 | Sample measurement device, reagent container, and sample measurement method |
| CN111630393A (en) * | 2018-01-25 | 2020-09-04 | 希森美康株式会社 | Sample measurement device and method for circulating air in reagent storage |
| US11959914B2 (en) | 2018-03-16 | 2024-04-16 | Hitachi High-Tech Corporation | Automatic analyzer and analysis method |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0435481A2 (en) * | 1989-12-22 | 1991-07-03 | Anagen (U.K.) Limited | Apparatus and method for selective agitation of reaction components |
| EP0631816A1 (en) * | 1993-07-01 | 1995-01-04 | Johnson & Johnson Clinical Diagnostics, Inc. | Bottle holders |
| US20020132353A1 (en) * | 2000-12-27 | 2002-09-19 | Tomoaki Tamura | Turntable type liquid reagent stirring apparatus and turntable type liquid reagent stirring/fractionally pouring apparatus using said stirring apparatus |
| JP2006189306A (en) * | 2005-01-05 | 2006-07-20 | Juki Corp | Well plate stirring device |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10360526A1 (en) * | 2003-12-22 | 2005-07-14 | Roche Diagnostics Gmbh | Reagent cassette with reagent container for particle-containing reagent for its noninvasive homogenization |
| US7731414B2 (en) * | 2007-02-08 | 2010-06-08 | Instrumentation Laboratory Company | Reagent cartridge mixing tube |
-
2013
- 2013-06-24 CN CN201380030169.5A patent/CN104395760B/en not_active Expired - Fee Related
- 2013-06-24 WO PCT/JP2013/067259 patent/WO2014002952A1/en active Application Filing
- 2013-06-24 JP JP2014522617A patent/JP6012728B2/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0435481A2 (en) * | 1989-12-22 | 1991-07-03 | Anagen (U.K.) Limited | Apparatus and method for selective agitation of reaction components |
| EP0631816A1 (en) * | 1993-07-01 | 1995-01-04 | Johnson & Johnson Clinical Diagnostics, Inc. | Bottle holders |
| US20020132353A1 (en) * | 2000-12-27 | 2002-09-19 | Tomoaki Tamura | Turntable type liquid reagent stirring apparatus and turntable type liquid reagent stirring/fractionally pouring apparatus using said stirring apparatus |
| JP2006189306A (en) * | 2005-01-05 | 2006-07-20 | Juki Corp | Well plate stirring device |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107037226A (en) * | 2015-11-13 | 2017-08-11 | 古野电气株式会社 | Analytical equipment |
| CN107037226B (en) * | 2015-11-13 | 2022-01-11 | 古野电气株式会社 | Analysis device |
| CN107044922A (en) * | 2017-01-20 | 2017-08-15 | 广东顺德工业设计研究院(广东顺德创新设计研究院) | Sampler |
| CN111630394A (en) * | 2018-01-25 | 2020-09-04 | 希森美康株式会社 | Sample measurement device, reagent container, and sample measurement method |
| CN111630393A (en) * | 2018-01-25 | 2020-09-04 | 希森美康株式会社 | Sample measurement device and method for circulating air in reagent storage |
| US11994527B2 (en) | 2018-01-25 | 2024-05-28 | Sysmex Corporation | Sample measuring apparatus and method of circulating air in reagent storage |
| US11959914B2 (en) | 2018-03-16 | 2024-04-16 | Hitachi High-Tech Corporation | Automatic analyzer and analysis method |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2014002952A1 (en) | 2014-01-03 |
| JPWO2014002952A1 (en) | 2016-05-30 |
| JP6012728B2 (en) | 2016-10-25 |
| CN104395760B (en) | 2016-08-24 |
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