WO2020253371A1 - 一种生化分析仪 - Google Patents

一种生化分析仪 Download PDF

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Publication number
WO2020253371A1
WO2020253371A1 PCT/CN2020/086462 CN2020086462W WO2020253371A1 WO 2020253371 A1 WO2020253371 A1 WO 2020253371A1 CN 2020086462 W CN2020086462 W CN 2020086462W WO 2020253371 A1 WO2020253371 A1 WO 2020253371A1
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WO
WIPO (PCT)
Prior art keywords
sample
sampling
pipetting
casing
card
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Application number
PCT/CN2020/086462
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English (en)
French (fr)
Inventor
王保学
丁真真
苗苗
周泽奇
粟艳
Original Assignee
丹娜（天津）生物科技有限公司
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Application filed by 丹娜（天津）生物科技有限公司 filed Critical 丹娜（天津）生物科技有限公司
Priority to US16/886,663 priority Critical patent/US20200400700A1/en
Publication of WO2020253371A1 publication Critical patent/WO2020253371A1/zh

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00584—Control arrangements for automatic analysers
    • G01N35/00722—Communications; Identification
    • G01N35/00732—Identification of carriers, materials or components in automatic analysers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/025—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations having a carousel or turntable for reaction cells or cuvettes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1009—Characterised by arrangements for controlling the aspiration or dispense of liquids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N2035/00465—Separating and mixing arrangements

Definitions

  • the invention relates to the technical field of medical equipment, in particular to a biochemical analyzer.
  • IFD Invasive Fungal Disease
  • invasive fungal infection refers to the pathological changes and pathophysiological processes of fungi that invade human tissues and blood, and grow and reproduce in them, leading to tissue damage, organ dysfunction, and inflammation .
  • Common invasive fungal diseases include invasive candidiasis, aspergillosis, cryptococcosis, cyanobacteria marneffei, and capsular histoplasmosis.
  • the identification and diagnosis methods used for pathogenic fungi mainly include pathological biopsy or direct microscopy of clinical specimens, pathogen isolation and culture identification, in addition to enzyme-linked immunoassay, chemiluminescence immunoassay, biochemical and turbidity
  • pathological biopsy or direct microscopy of clinical specimens pathogen isolation and culture identification
  • enzyme-linked immunoassay chemiluminescence immunoassay
  • biochemical and turbidity In the field of diagnostics, laboratories, and food safety monitoring, it is often necessary to complete operations such as sampling of trace samples, filling of accurate quantitative reagents, and the use of a series of pipetting instruments, all requiring dedicated laboratories and a large number of corresponding laboratory instruments, the operation process Trivial and inefficient, wasting manpower and material resources.
  • the purpose of the present invention is to provide a biochemical analyzer capable of simply and efficiently inspecting and analyzing samples.
  • the present invention adopts the following technical solutions:
  • a biochemical analyzer including:
  • a casing which is provided with a sample inlet and a sample outlet;
  • the sampling mechanism is arranged in the casing, and can introduce the test card containing the sample and the reagent into the casing from the sampling port;
  • a rotating mechanism which is arranged in the casing, can hold a plurality of the test cards, and drive the test cards to rotate, and the sampling mechanism can lock the test cards on the rotating mechanism;
  • the pipetting mechanism is arranged in the casing and above the rotation mechanism, and can mix the sample on the test card with the reagent;
  • the analysis mechanism is arranged in the casing and can analyze the sample by detecting rays
  • a sampling mechanism is arranged in the casing and used to remove the detection card from the rotating mechanism
  • the sample output box is slidably arranged at the sample output port, and is used to contain the detected test card, and the sample output mechanism can guide the test card into the sample output box.
  • the sampling mechanism includes:
  • the sampling slide is arranged in the casing
  • the sample injection support seat is slidably arranged on the sample injection slide rail, and the detection card can be placed on the sample injection support seat;
  • the sampling drive device is arranged in the casing and can drive the sampling support seat to slide along the sampling slide.
  • the sampling mechanism further includes a sampling detection device, the sampling detection device is arranged in the casing, located on one side of the sampling slide, and used to detect the sampling support Whether there is a test card.
  • the rotating mechanism includes:
  • a rotating disk is rotatably arranged in the casing, and a plurality of clamping positions are uniformly arranged in the circumferential direction of the rotating disk, and each of the clamping positions can be loaded with one detection card;
  • the rotating drive device is arranged in the casing and can drive the rotating disk to rotate.
  • a card mounting slot is provided on the card mounting position
  • a card protrusion is provided on the detection card, and the card protrusion can be inserted into the card mounting slot under the pushing of the sampling mechanism.
  • the sample introduction mechanism cannot drive the locking protrusion to escape from the locking groove.
  • the pipetting mechanism includes:
  • the pipetting holder is arranged in the casing
  • a pipetting sliding seat slidably arranged on the pipetting fixed seat, the sliding direction of the pipetting sliding seat is perpendicular to the rotation axis of the rotating mechanism;
  • a pipetting head slidably arranged on the pipetting sliding seat and used for transferring the reagent on the detection card, the sliding direction of the pipetting head is parallel to the rotation axis of the rotating mechanism;
  • the first pipetting drive device is arranged on the pipetting fixing seat and can drive the pipetting sliding seat to slide;
  • the second pipetting driving device is arranged on the pipetting sliding seat and can drive the pipetting head to slide.
  • the pipetting mechanism further includes a pipetting support seat, the pipetting support seat is arranged in the housing and used for supporting the rotating mechanism at the pipetting position.
  • the sampling mechanism includes:
  • the sample slide rail is arranged in the casing
  • the sample output support seat is slidably arranged on the sample output slide rail;
  • the sample output drive device is arranged in the casing and can drive the sample output support seat to slide along the sample output slide rail.
  • the detection device on the rotating mechanism can be The card is removed and pushed into the sample output box.
  • the sample output box includes:
  • the box body is used to contain the test card after the test, and is slidably arranged at the sample outlet, the box body is provided with an introduction port, and the sampling mechanism can pass the test card through the introduction port Into the box;
  • a pushing device arranged in the casing, for pushing the detection card in the box to move to the detection end of the box;
  • the sample discharge detection device is arranged in the casing, and the sample discharge detection device can be triggered when the detection card in the box abuts against the detection end.
  • a closed door is rotatably provided at the sampling port, and the sampling mechanism can push the closed door to open during sample injection, and the closed door can close the sampling port after the sample is completed.
  • the coordinated setting of the sampling mechanism, rotating mechanism, pipetting mechanism, analysis mechanism, and sample output mechanism can automatically, simply and efficiently inspect and analyze multiple samples, saving manpower and material resources, and making the inspection process safer. The result is more reliable.
  • Fig. 1 is a schematic structural diagram of a biochemical analyzer according to an embodiment of the present invention
  • FIG. 2 is a schematic diagram of the structure of some parts of the biochemical analyzer according to an embodiment of the present invention.
  • Figure 3 is a schematic structural diagram of a sample introduction mechanism according to an embodiment of the present invention.
  • FIG. 4 is a schematic diagram of the structure of the rotating mechanism according to the embodiment of the present invention.
  • FIG. 5 is a schematic diagram of the structure of the pipetting mechanism according to an embodiment of the present invention.
  • FIG. 6 is a schematic structural diagram of an analysis mechanism according to an embodiment of the present invention.
  • Figure 7 is a schematic structural diagram of the sample delivery mechanism according to an embodiment of the present invention.
  • Figure 8 is a schematic structural view of one orientation of the sample output box according to an embodiment of the present invention.
  • Fig. 9 is a schematic structural diagram of another orientation of the sample output box according to the embodiment of the present invention.
  • Rotating mechanism 31. Rotating disc; 311. Card slot; 32. Rotating drive device;
  • Pipette mechanism 41. Pipette holder; 42, Pipette sliding seat; 43, Pipette head; 44, First pipette drive device; 45, Second pipette drive device; 46, Pipette support seat ;
  • Sampling mechanism 61. Sampling slide; 62. Sampling support seat; 63. Sampling drive device;
  • connection shall be understood in a broad sense unless otherwise clearly specified and limited.
  • it may be a fixed connection, a detachable connection, or a mechanical connection.
  • the connection may also be an electrical connection, a direct connection, or an indirect connection through an intermediate medium, and it may be a connection between two elements or an interaction relationship between two elements.
  • connection may also be an electrical connection, a direct connection, or an indirect connection through an intermediate medium, and it may be a connection between two elements or an interaction relationship between two elements.
  • the "above” or “below” of the first feature of the second feature may include direct contact between the first feature and the second feature, or may include the first feature The second feature is not in direct contact but is in contact with another feature between them.
  • “above”, “above” and “above” the second feature of the first feature include the first feature being directly above and obliquely above the second feature, or it simply means that the level of the first feature is higher than the second feature.
  • the “below”, “below” and “below” the first feature of the second feature include the first feature directly below and obliquely below the second feature, or it simply means that the level of the first feature is smaller than the second feature.
  • the present invention provides a biochemical analyzer, including a casing 1, a sampling mechanism 2, a rotating mechanism 3, a pipetting mechanism 4, an analysis mechanism 5, a sampling mechanism 6 and a sampling box 7.
  • the casing 1 is provided with a sample inlet and a sample outlet
  • the sampling mechanism 2 is arranged in the casing 1.
  • the test card containing samples and reagents can be introduced into the casing 1 from the inlet, and the rotating mechanism 3 is set in the casing 1, which can install multiple detection cards and drive the detection card to rotate, the sampling mechanism 2 can install the detection card on the rotating mechanism 3, and the pipetting mechanism 4 is provided in the casing 1, located Above the rotating mechanism 3, the sample on the test card can be mixed with the reagent.
  • the analysis mechanism 5 is installed in the casing 1, and the sample can be analyzed by detecting rays.
  • the sample output mechanism 6 is installed in the casing 1. It is used to remove the test card from the rotating mechanism 3, the sample output box 7 is slidably arranged at the sample output port, and is used to contain the tested test card. The sample output mechanism 6 can guide the test card into the sample output box 7.
  • the sampling mechanism 2, the rotating mechanism 3, the pipetting mechanism 4, the analysis mechanism 5, and the sample output mechanism 6 are arranged in cooperation, which can automatically inspect and analyze multiple samples in a simple and efficient manner, saving manpower and material resources. , Making the inspection process safer and the inspection structure more reliable.
  • the pipetting mechanism 4 and the analysis mechanism 5 are respectively located on the upper and lower sides of the rotating mechanism 3, and are arranged directly opposite.
  • the pipetting operation and the analysis mechanism 5 can be performed synchronously or asynchronously.
  • the analysis mechanism 5 includes a detection module capable of emitting detection radiation and an analysis module capable of analyzing the detection radiation.
  • the analysis module analyzes the detection radiation passing through the sample to obtain the detection result of the sample.
  • the rotating mechanism 3 rotates, The sample in the upper test card can pass between the test module and the analysis module.
  • the analysis mechanism 5 is a conventional setting in the field, and its structure and principles are not repeated here.
  • each analysis mechanism 5 can detect one test card, and multiple analysis mechanisms 5 can analyze different components in the sample through different detection rays.
  • four analysis mechanisms 5 are specifically provided.
  • a control mechanism is provided in the casing 1, which controls the sampling mechanism 2, the pipetting mechanism 4, the analysis mechanism 5, and the sample discharge mechanism 6 to cooperate to complete the test of the sample automatically.
  • This control mechanism is a professional in the field. The general setting, its specific structure and working principle will not be repeated here.
  • the sampling mechanism 2 includes a sampling slide rail 21, a sampling support base 22 and a sampling driving device 23.
  • the sampling slide rail 21 is arranged in the casing 1 and extends along the radial direction of the rotating mechanism 3, the sampling support base 22 is slidably arranged on the sampling slide rail 21, and the detection card can be placed on the sampling support base 22,
  • the sampling drive device 23 is arranged in the casing 1 and can drive the sampling support base 22 to slide along the sampling slide 21.
  • the sampling drive device 23 includes a first motor and a first transmission belt driven by the first motor.
  • the sampling support base 22 is connected to the first transmission belt, and the first motor is controlled by a control mechanism to start and stop and forward and reverse.
  • the sampling mechanism 2 further includes a sampling detection device 24.
  • the sampling detection device 24 is arranged in the casing 1 on one side of the sampling slide rail 21 and used to detect whether the sampling support 22 is placed There is a test card.
  • the sample injection detection device 24 is a photoelectric sensor connected to the control mechanism.
  • the control mechanism controls the first motor to start, and the first transmission rotates to drive the sampling support base 22 to slide toward the rotation mechanism 3, and the detection card is clamped on the rotation mechanism 3. If the detection card is not Installed on the rotating mechanism 3, when the sampling support base 22 is reset to the inside of the injection port, the detection card on it will trigger the sampling detection device 24 again, and the control mechanism will control the sampling drive mechanism to perform the clamping again .
  • the rotating mechanism 3 includes a rotating disk 31 and a rotating drive device 32.
  • the rotating disk 31 is rotatably arranged in the casing 1, and the rotating disk 31 is evenly provided with a plurality of clamping positions in the circumferential direction, and each clamping position can be fitted with a detection card, and the rotating driving device 32 is arranged in the casing 1. Inside, it can drive the rotating disk 31 to rotate.
  • the rotation driving device 32 includes a second motor and a second transmission belt driven by the second motor.
  • the second transmission belt is wound on the rotating disk 31 and can drive the rotating disk 31 to rotate around its own axis.
  • the above-mentioned second motor is controlled by the control mechanism to start and stop, so that it can be more closely connected with the sampling mechanism 2.
  • a card mounting slot 311 is provided on the card mounting position, and a card protrusion is provided on the detection card.
  • the card protrusion can be inserted into the card mounting slot 311 under the push of the sampling mechanism 2, and the sample injection mechanism 2 cannot drive the card.
  • the protrusion comes out of the clamping slot 311.
  • a pressing block is provided on the rotating disk 31, and a flange is provided circumferentially on the top of the detection card, and the flange can be clamped between the pressing block and the rotating disk 31.
  • the pipetting mechanism 4 includes a pipetting fixing seat 41, a pipetting sliding seat 42, a pipetting head 43, a first pipetting driving device 44 and a second pipetting driving device 45.
  • the pipetting fixing seat 41 is arranged in the casing 1
  • the pipetting sliding seat 42 is slidably arranged on the pipetting fixing seat 41
  • the sliding direction of the pipetting sliding seat 42 is perpendicular to the rotation axis of the rotating disk 31
  • the pipetting head 43 is slidably arranged on the pipetting sliding seat 42 for transferring reagents on the test card.
  • the sliding direction of the pipetting head 43 is parallel to the rotation axis of the rotating disk 31, and the first pipetting driving device 44 is arranged on the pipetting fixing seat 41, can drive the pipetting sliding seat 42 to slide, and the second pipetting driving device 45 is arranged on the pipetting sliding seat 42 and can drive the pipetting head 43 to slide.
  • the pipetting sliding seat 42 is slidably arranged on the slide rail of the pipetting fixing seat 41, the pipetting head 43 slides along the radial direction of the rotating disk 31, and the first pipetting driving device 44 includes a third motor and a third motor. Driven by the third transmission belt, the pipetting sliding seat 42 is connected to the third transmission belt and is driven by the third transmission belt to slide.
  • the second pipetting drive device 45 includes a fourth motor, a fourth transmission belt driven by the fourth motor, and a fourth transmission belt.
  • the pipetting head 43 is connected to the nut and can move along the axial direction of the screw with the nut.
  • the pipetting head 43 is a syringe driven by the fifth motor and the screw. Reagents can be transferred automatically.
  • the aforementioned third motor, fourth motor, and fifth motor are all controlled by the control mechanism, so that the reagent can be transferred more accurately.
  • the pipetting mechanism 4 further includes a pipetting support base 46, which is provided in the casing 1 and used to support the rotating mechanism 3 at the pipetting position.
  • the pipetting support 46 is arranged on one side of the rotating disc 31, and is arranged around a clamping position in cooperation with the pipetting mechanism 4, so that the detection card at the clamping position is more effective when pipetting. Stable and not easy to deflect.
  • the pipetting support seat 46 includes a seat body fixed in the casing 1, a roller rotatably arranged on the seat body, and an upper pressure plate fixedly arranged on the seat body.
  • the roller supports the rotating disk 31 from the lower side, and the upper pressure plate The upper side abuts against the rotating disk 31.
  • the sampling mechanism 6 includes a sampling sliding rail 61, a sampling supporting seat 62 and a sampling driving device 63.
  • the sample out slide rail 61 is arranged in the casing 1
  • the sample out support seat 62 is slidably arranged on the sample out slide rail 61
  • the sample out drive device 63 is arranged in the casing 1, which can drive the sample out support seat 62 along the The sample slide rail 61 slides, and when the sample output support 62 slides, the detection card on the rotating mechanism 3 can be immediately lowered and pushed into the sample output box 7.
  • the sample output drive device 63 includes a sixth motor and a sixth transmission belt driven by the sixth motor.
  • the sample output support base 62 is connected to the sixth transmission belt and is driven to slide by the sixth transmission belt.
  • the aforementioned sixth motor is controlled by the control mechanism.
  • the sample ejection box 7 includes a box body 71, a pushing device 72 and a sample ejection detection device 73.
  • the box body 71 is used to contain the test card after the test, and is slidably arranged at the sample outlet.
  • the box body 71 is provided with an introduction port 711.
  • the sampling mechanism 6 can introduce the test card into the box body 71 through the introduction port 711.
  • the pushing device 72 is arranged in the casing 1 for pushing the detection card in the casing 71 to move to the detection end of the casing 71, and the sampling detection device 73 is arranged in the casing 1, and the detection card in the casing 71 abuts
  • the sample detection device 73 can be triggered at the detection end.
  • the pushing device 72 includes a seventh motor, a screw rod driven by the seventh motor, a nut screwed on the screw rod, and a push plate connected to the nut.
  • the push plate is connected to a guide post, and the guide post penetrates In a guide hole, the push plate can push the detection card in the box body 71 when it moves along the axial direction of the guide column.
  • the above-mentioned seventh motor is controlled by the control mechanism.
  • the sample discharge detection device 73 is a photoelectric sensor, which is connected to the control mechanism.
  • the detection end of the box body 71 is provided with a ray penetration port.
  • the sample discharge detection device 73 can be triggered.
  • the control mechanism controls the corresponding alarm prompt device to remind the operator to withdraw the box 71 that has been full of the detection card for cleaning.
  • a closed door is rotatably provided at the sample inlet, and the sample injection mechanism 2 can push the closed door to open during sample injection, and the closed door can close the sample inlet after the sample is completed.
  • the closing door 11 is L-shaped, which is compatible with the L-shaped injection port, and is rotatably arranged at the injection port by a return spring, so that the enclosure 1 can be sealed.
  • an analysis display screen 12 and an acrylic see-through board 13 are also provided on the casing 1.
  • the analysis display screen 12 is connected to the control mechanism. The operator can see the analysis structure of the test card through the analysis display screen 12, and can see through the acrylic The board 13 observes the operation of each mechanism in the casing 1.
  • the casing 1 is also provided with a switch button or a knob, a code scanning port for scanning and detecting information on the card, a running status indicator, a power interface, and a USB information interface.
  • the biochemical analyzer in this application improves the detection sensitivity, increases the product stability, shortens the detection time, simplifies the operation process, saves labor costs, and makes the product accuracy, sensitivity, rapidity, repeatability, etc. compared with the prior art It has obvious improvements and plays an important role in technology development, product development, clinical application and market expansion.
  • the platform technology can also be extended to the early diagnosis of major diseases such as microbial inflammation, infection, cardiovascular and cerebrovascular diseases, and respiratory diseases based on immunoturbidimetric methodology and enzymatic kinetics, and complete breakthroughs in technical bottlenecks in the field of in vitro diagnostics. It has great development prospects and will play a transformative role in the early diagnosis, condition monitoring and guidance and treatment of major diseases such as AIDS, tuberculosis, hepatitis and other major diseases combined with IFD. The smooth implementation of the project will produce significant economic and social benefit.

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Abstract

一种生化分析仪，包括机壳（1）、进样机构（2）、转动机构（3）、移液机构（4）、分析机构（5）、出样机构（6）和出样盒（7），机壳（1）上设置有进样口和出样口，进样机构（2）设置于机壳（1）内，能够将盛装有试样和试剂的检测卡从进样口导入机壳（1）内，转动机构（3）能够装卡多个检测卡，并带动检测卡转动，进样机构（2）能够将检测卡装卡于转动机构（3）上，移液机构（4）能够将检测卡上的试样与试剂进行混合，分析机构（5）能够通过检测射线对试样进行分析，出样机构（6）用于将检测卡从转动机构（3）上移出，出样盒（7）滑动设置于出样口处，用于盛装检测完毕的检测卡，出样机构（6）能够将检测卡导入出样盒（7）内。该生化分析仪能够全自动简单高效地对多个试样进行检验分析，节省人力和物力。

Description

一种生化分析仪 技术领域
本发明涉及医用设备技术领域，尤其涉及一种生化分析仪。
背景技术
侵袭性真菌病(Invasive Fungal Disease,IFD)，又称侵袭性真菌感染，是指真菌侵入人体组织、血液，并在其中生长繁殖导致组织损害、器官功能障碍和炎症反应的病理改变及病理生理过程。常见的侵袭性真菌病有侵袭性念珠菌病、曲霉菌病、隐球菌病、马尔尼菲蓝状菌病、荚膜组织胞浆菌病等。目前，用于病原真菌的鉴定诊断方法主要有临床标本的病理活检或直接镜检、病原体分离和培养鉴定，除此之外，在酶联免疫检测、化学发光免疫检测以及生化和比浊等临床诊断领域、实验室、食品安全监控领域，经常需要完成微量样品的采样、精确定量试剂的加注以及系列移液器具的使用等操作，均需要专用实验室及大量相应的实验室器具，操作过程繁琐低效，浪费人力物力。
发明内容
本发明的目的在于提供一种生化分析仪，能够简单高效地对试样进行检验分析。
为达此目的，本发明采用以下技术方案：
一种生化分析仪，包括：
机壳，所述机壳上设置有进样口和出样口；
进样机构，设置于所述机壳内，能够将盛装有试样和试剂的检测卡从进样口导入所述机壳内；
转动机构，设置于所述机壳内，能够装卡多个所述检测卡，并带动所述检测卡转动，所述进样机构能够将所述检测卡装卡于所述转动机构上；
移液机构，设置于所述机壳内，位于所述转动机构的上方，能够将检测卡上的试样与试剂进行混合；
分析机构，设置于所述机壳内，能够通过检测射线对试样进行分析；
出样机构，设置于所述机壳内，用于将所述检测卡从所述转动机构上移出；
出样盒，滑动设置于所述出样口处，用于盛装检测完毕的所述检测卡，所述出样机构能够将所述检测卡导入所述出样盒内。
作为优选，所述进样机构包括：
进样滑轨，设置于所述机壳内；
进样支撑座，滑动设置于所述进样滑轨上，所述检测卡能够放置于所述进样支撑座上；
进样驱动装置，设置于所述机壳内，能够带动所述进样支撑座沿所述进样滑轨滑动。
作为优选，所述进样机构还包括进样检测装置，所述进样检测装置设置于所述机壳内，位于所述进样滑轨的一侧，用于检测所述进样支撑座上是否放置有检测卡。
作为优选，所述转动机构包括：
转动盘，转动设置于所述机壳内，所述转动盘周向上均布设置有多个装卡位，每个所述装卡位处能够装卡一个所述检测卡；
转动驱动装置，设置于所述机壳内，能够带动所述转动盘转动。
作为优选，所述装卡位上设置有卡装槽，所述检测卡上设置有卡凸，所述卡凸能够在所述进样机构的推动下卡入所述卡装槽内，所述进样机构不能带动所述卡凸从所述卡装槽内脱出。
作为优选，所述移液机构包括：
移液固定座，设置于所述机壳内；
移液滑动座，滑动设置于所述移液固定座上，所述移液滑动座的滑动方向垂直于所述转动机构的转动轴向；
移液头，滑动设置于所述移液滑动座上，用于移送所述检测卡上的试剂，所述移液头的滑动方向平行于所述转动机构的转动轴向；
第一移液驱动装置，设置于所述移液固定座上，能够带动所述移液滑动座滑动；
第二移液驱动装置，设置于所述移液滑动座上，能够带动所述移液头滑动。
作为优选，所述移液机构还包括移液支撑座，所述移液支撑座设置于所述机壳内，用于在移液位置处对所述转动机构进行支撑。
作为优选，所述出样机构包括：
出样滑轨，设置于所述机壳内；
出样支撑座，滑动设置于所述出样滑轨上；
出样驱动装置，设置于所述机壳内，能够带动所述出样支撑座沿所述出样滑轨滑动，所述出样支撑座滑动时，能够将所述转动机构上的所述检测卡取下并推入所述出样盒内。
作为优选，所述出样盒包括：
盒体，用于盛装检测完毕的所述检测卡，滑动设置于所述出样口处，所述盒体上设置有导入口，所述出样机构能够将所述检测卡通过所述导入口导入所述盒体内；
推动装置，设置于所述机壳内，用于推动所述盒体内的所述检测卡向所述盒体的检测端移动；
出样检测装置，设置于所述机壳内，所述盒体内的所述检测卡抵靠所述检测端时能够触发所述出样检测装置。
作为优选，所述进样口处转动设置有封闭门，进样时，所述进样机构能够推动所述封闭门打开，进样结束后，所述封闭门能够封闭所述进样口。
本发明的有益效果：
进样机构、转动机构、移液机构、分析机构和出样机构的配合设置，能够全自动简单高效地对多个试样进行检验分析，节省了人力和物力，使得检验的过程更加安全，检验的结果更加可靠。
附图说明
图1是本发明实施例所述的生化分析仪的结构示意图；
图2是本发明实施例所述的生化分析仪部分零部件的结构示意图；
图3是本发明实施例所述的进样机构的结构示意图；
图4是本发明实施例所述的转动机构的结构示意图；
图5是本发明实施例所述的移液机构的结构示意图；
图6是本发明实施例所述的分析机构的结构示意图；
图7是本发明实施例所述的出样机构的结构示意图；
图8是本发明实施例所述的出样盒一个位向的结构示意图；
图9是本发明实施例所述的出样盒另一位向的结构示意图。
图中：
1、机壳；11、封闭门；12、分析显示屏；13、亚克力透视板；
2、进样机构；21、进样滑轨；22、进样支撑座；23、进样驱动装置；24、进样检测装置；
3、转动机构；31、转动盘；311、卡装槽；32、转动驱动装置；
4、移液机构；41、移液固定座；42、移液滑动座；43、移液头；44、第一移液驱动装置；45、第二移液驱动装置；46、移液支撑座；
5、分析机构；
6、出样机构；61、出样滑轨；62、出样支撑座；63、出样驱动装置；
7、出样盒；71、盒体；711、导入口；72、推动装置；73、出样检测装置。
具体实施方式
下面详细描述本发明的实施例，实施例的示例在附图中示出，其中自始至终相同或类似的标号表示相同或类似的元件或具有相同或类似功能的元件。下面通过参考附图描述的实施例是示例性的，旨在用于解释本发明，而不能理解为对本发明的限制。
在本发明的描述中，除非另有明确的规定和限定，术语“相连”、“连接”、“固定”应做广义理解，例如，可以是固定连接，也可以是可拆卸连接，可以是机械连接，也可以是电连接，可以是直接相连，也可以通过中间媒介间接相连，可以是两个元件内部的连通或两个元件的相互作用关系。对于本领域的普通技术人员而言，可以根据具体情况理解上述术语在本发明中的具体含义。
在本发明的描述中，除非另有明确的规定和限定，第一特征在第二特征之“上”或之“下”可以包括第一特征和第二特征直接接触，也可以包括第一特征和第二特征不是直接接触而是通过它们之间的另外的特征接触。而且，第一特征在第二特征“之上”、“上方”和“上面”包括第一特征在第二特征正上方和斜上方，或仅仅表示第一特征水平高度高于第二特征。第一特征在第二特征“之下”、“下方”和“下面”包括第一特征在第二特征正下方和斜下方，或仅仅表示第一特征水平高度小于第二特征。
下面结合附图并通过具体实施方式来进一步说明本发明的技术方案。
如图1-图9所示，本发明提供了一种生化分析仪，包括机壳1、进样机构2、转动机构3、移液机构4、分析机构5、出样机构6和出样盒7。其中，机壳1上设置有进样口和出样口，进样机构2设置于机壳1内，能够将盛装有试样和试剂的检测卡从进样口导入机壳1内，转动机构3设置于机壳1内，能够装卡多个 检测卡，并带动检测卡转动，进样机构2能够将检测卡装卡于转动机构3上，移液机构4设置于机壳1内，位于转动机构3的上方，能够将检测卡上的试样与试剂进行混合，分析机构5设置于机壳1内，能够通过检测射线对试样进行分析，出样机构6设置于机壳1内，用于将检测卡从转动机构3上移出，出样盒7滑动设置于出样口处，用于盛装检测完毕的检测卡，出样机构6能够将检测卡导入出样盒7内。
本发明中，进样机构2、转动机构3、移液机构4、分析机构5和出样机构6的配合设置，能够全自动简单高效地对多个试样进行检验分析，节省了人力和物力，使得检验的过程更加安全，检验的结构更加可靠。
在本实施例中，移液机构4和分析机构5分别位于转动机构3的上下两侧，正对设置，移液的操作和分析机构5的操作可以同步进行也可以异步进行。其中，分析机构5包括能够发出检测射线的检测模块和能够对检测射线进行分析的分析模块，分析模块对穿过试样的检测射线进行分析得到试样的检测结果，转动机构3转动时，其上的检测卡中的试样能够从检测模块和分析模块之间穿过。具体地，分析机构5为本领域的常规设置，其结构和原理在此不再赘述。
具体地，分析机构5设置有多个，每个分析机构5可以对一个检测卡进行检测，多个分析机构5可以通过不同的检测射线分析试样中不同的成分。在本实施例中，分析机构5具体设置有四个。
具体地，机壳1内设置有控制机构，控制进样机构2、移液机构4、分析机构5和出样机构6协同动作，全自动地完成试样的检验，此控制机构为本领域的常规设置，其具体结构和工作原理在此不再赘述。
可选择地，进样机构2包括进样滑轨21、进样支撑座22和进样驱动装置23。其中，进样滑轨21设置于机壳1内，沿转动机构3的径向延伸，进样支撑座22滑动设置于进样滑轨21上，检测卡能够放置于进样支撑座22上，进样驱动装置23设置于机壳1内，能够带动进样支撑座22沿进样滑轨21滑动。
具体地，进样驱动装置23包括第一电机和由第一电机带动的第一传动带，进样支撑座22连接于第一传动带，第一电机由控制机构控制启停和正反转。
更为具体地，进样机构2还包括进样检测装置24，进样检测装置24设置于机壳1内，位于进样滑轨21的一侧，用于检测进样支撑座22上是否放置有检测卡。在本实施例中，进样检测装置24为光电传感器，连接于控制机构，进样支 撑座22从进样口外缩回时，若其上有检测卡，则检测卡可以触发进样检测装置24，进样检测装置24触发后，控制机构控制第一电机启动，第一传动转动从而带动进样支撑座22朝向转动机构3滑动，将检测卡卡装于转动机构3上，若检测卡未卡装于转动机构3上，则在进样支撑座22复位至进样口内侧时，其上的检测卡会再次触发进样检测装置24，此时控制机构会控制进样驱动机构进行再次卡装。
可选择地，转动机构3包括转动盘31和转动驱动装置32。其中，转动盘31转动设置于机壳1内，转动盘31周向上均布设置有多个装卡位，每个装卡位处能够装卡一个检测卡，转动驱动装置32设置于机壳1内，能够带动转动盘31转动。
具体地，转动驱动装置32包括第二电机和由第二电机带动的第二传动带，第二传动带绕设于转动盘31上，能够带动转动盘31绕自身轴线转动。
更为具体地，上述第二电机由控制机构控制启停，从而可以与进样机构2更加良好地衔接配合。
更为具体地，装卡位上设置有卡装槽311，检测卡上设置有卡凸，卡凸能够在进样机构2的推动下卡入卡装槽311内，进样机构2不能带动卡凸从卡装槽311内脱出。
更为具体地，转动盘31上设置有压块，检测卡的顶部周向设置有凸缘，凸缘能够卡入压块和转动盘31之间。
可选择地，移液机构4包括移液固定座41、移液滑动座42、移液头43、第一移液驱动装置44和第二移液驱动装置45。其中，移液固定座41设置于机壳1内，移液滑动座42滑动设置于移液固定座41上，移液滑动座42的滑动方向垂直于转动盘31的转动轴向，移液头43滑动设置于移液滑动座42上，用于移送检测卡上的试剂，移液头43的滑动方向平行于转动盘31的转动轴向，第一移液驱动装置44设置于移液固定座41上，能够带动移液滑动座42滑动，第二移液驱动装置45设置于移液滑动座42上，能够带动移液头43滑动。
具体地，移液滑动座42滑动设置于移液固定座41的滑轨上，移液头43沿转动盘31的径向滑动，第一移液驱动装置44包括第三电机和由第三电机带动的第三传动带，移液滑动座42连接于第三传动带，由第三传动带带动滑移，第二移液驱动装置45包括第四电机、由第四电机带动的第四传动带、由第四传动带 带动的丝杆和螺接于丝杆的螺母，移液头43连接于螺母，且能够随螺母沿丝杆的轴向移动，移液头43为由第五电机配合丝杠驱动的注射器，可以自动移送试剂。
更为具体地，上述第三电机、第四电机和第五电机均由控制机构控制，从而可以更加精确地移送试剂。
具体地，移液机构4还包括移液支撑座46，移液支撑座46设置于机壳1内，用于在移液位置处对转动机构3进行支撑。
在本实施例中，移液支撑座46设置于转动盘31的一侧，与移液机构4相互配合围绕一个装卡位设置，从而使得在移液时，该装卡位处的检测卡更加平稳，不易偏斜。
具体地，移液支撑座46包括固设于机壳1内的座体、转动设置于座体上的滚轮和固定设置于座体的上压板，滚轮从下侧支撑转动盘31，上压板从上侧抵靠转动盘31。
可选择地，出样机构6包括出样滑轨61、出样支撑座62和出样驱动装置63。其中，出样滑轨61设置于机壳1内，出样支撑座62滑动设置于出样滑轨61上，出样驱动装置63设置于机壳1内，能够带动出样支撑座62沿出样滑轨61滑动，出样支撑座62滑动时，能够将转动机构3上的检测卡即下并推入出样盒7内。
具体地，出样驱动装置63包括第六电机和由第六电机带动的第六传动带，出样支撑座62连接于第六传动带，由第六传动带带动滑移。上述第六电机由控制机构进行控制。
更为具体地，出样盒7包括盒体71、推动装置72和出样检测装置73。其中，盒体71用于盛装检测完毕的检测卡，滑动设置于出样口处，盒体71上设置有导入口711，出样机构6能够将检测卡通过导入口711导入盒体71内，推动装置72设置于机壳1内，用于推动盒体71内的检测卡向盒体71的检测端移动，出样检测装置73设置于机壳1内，盒体71内的检测卡抵靠检测端时能够触发出样检测装置73。
在本实施例中，推动装置72包括第七电机、由第七电机带动的丝杆、螺接于丝杆的螺母和连接于螺母的推板，推板连接于一个导向柱，导向柱穿设于一导向孔内，推板沿导向柱的轴向移动时能够推动盒体71内的检测卡。上述第七电机由控制机构进行控制。
在本实施例中，出样检测装置73为光电传感器，连接于控制机构，盒体71的检测端设置有射线穿入口，检测卡封挡射线穿入口时能够触发出样检测装置73，出样检测装置73被触发时，控制机构控制相应的报警提示装置提醒操作人员将已经盛满检测卡的盒体71抽出进行清理。
可选择地，进样口处转动设置有封闭门，进样时，进样机构2能够推动封闭门打开，进样结束后，封闭门能够封闭进样口。
具体地，封闭门11呈L形，与L形的进样口相适配，其通过一复位弹簧转动设置于进样口处，从而可以保证机壳1的封闭。
可选择地，机壳1上还设置有分析显示屏12和亚克力透视板13，分析显示屏12连接于控制机构，操作人员可以通过分析显示屏12看到检测卡的分析结构，可以通过亚克力透视板13观察到机壳1内各机构的运行情况。
具体地，机壳1上还设置有开关按钮或旋钮、用于扫描检测卡上信息的扫码口、运行状态指示灯、电源接口以及USB信息接口。
本申请中的生化分析仪，提高了检测灵敏度、增加产品稳定性、缩短检测时间、简化操作流程、节约人工成本，使得产品准确性、灵敏性、快速性、重复性等相比于现有技术有着明显的改进，在技术发展、产品开发、临床应用和市场拓展中起到重要的作用。
另外，该平台技术还可拓展应用至基于免疫比浊方法学、酶促动力学的微生物炎症感染、心脑血管疾病、呼吸系统疾病等重大疾病的早期诊断，完成体外诊断领域的技术瓶颈突破，具有重大的发展前景，对IFD合并的如艾滋病、结核病、肝炎等重大疾病的早期诊断、病情监测和指导治疗带起到变革性的进步推动作用，该项目的顺利实施将产生显著的经济和社会效益。
显然，本发明的上述实施例仅仅是为了清楚说明本发明所作的举例，而并非是对本发明的实施方式的限定。对于所属领域的普通技术人员来说，在上述说明的基础上还可以做出其它不同形式的变化或变动。这里无需也无法对所有的实施方式予以穷举。凡在本发明的精神和原则之内所作的任何修改、等同替换和改进等，均应包含在本发明权利要求的保护范围之内。

Claims (10)

  1. 一种生化分析仪，其特征在于，包括：
    机壳(1)，所述机壳(1)上设置有进样口和出样口；
    进样机构(2)，设置于所述机壳(1)内，能够将盛装有试样和试剂的检测卡从进样口导入所述机壳(1)内；
    转动机构(3)，设置于所述机壳(1)内，能够装卡多个所述检测卡，并带动所述检测卡转动，所述进样机构(2)能够将所述检测卡装卡于所述转动机构(3)上；
    移液机构(4)，设置于所述机壳(1)内，位于所述转动机构(3)的上方，能够将检测卡上的试样与试剂进行混合；
    分析机构(5)，设置于所述机壳(1)内，能够通过检测射线对试样进行分析；
    出样机构(6)，设置于所述机壳(1)内，用于将所述检测卡从所述转动机构(3)上移出；
    出样盒(7)，滑动设置于所述出样口处，用于盛装检测完毕的所述检测卡，所述出样机构(6)能够将所述检测卡导入所述出样盒(7)内。
  2. 根据权利要求1所述的生化分析仪，其特征在于，所述进样机构(2)包括：
    进样滑轨(21)，设置于所述机壳(1)内；
    进样支撑座(22)，滑动设置于所述进样滑轨(21)上，所述检测卡能够放置于所述进样支撑座(22)上；
    进样驱动装置(23)，设置于所述机壳(1)内，能够带动所述进样支撑座(22)沿所述进样滑轨(21)滑动。
  3. 根据权利要求2所述的生化分析仪，其特征在于，所述进样机构(2)还包括进样检测装置(24)，所述进样检测装置(24)设置于所述机壳(1)内，位于所述进样滑轨(21)的一侧，用于检测所述进样支撑座(22)上是否放置有检测卡。
  4. 根据权利要求1所述的生化分析仪，其特征在于，所述转动机构(3)包括：
    转动盘(31)，转动设置于所述机壳(1)内，所述转动盘(31)周向上均布设置有多个装卡位，每个所述装卡位处能够装卡一个所述检测卡；
    转动驱动装置(32)，设置于所述机壳(1)内，能够带动所述转动盘(31)转动。
  5. 根据权利要求4所述的生化分析仪，其特征在于，所述装卡位上设置有卡装槽(311)，所述检测卡上设置有卡凸，所述卡凸能够在所述进样机构(2)的推动下卡入所述卡装槽(311)内，所述进样机构(2)不能带动所述卡凸从所述卡装槽(311)内脱出。
  6. 根据权利要求1所述的生化分析仪，其特征在于，所述移液机构(4)包括：
    移液固定座(41)，设置于所述机壳(1)内；
    移液滑动座(42)，滑动设置于所述移液固定座(41)上，所述移液滑动座(42)的滑动方向垂直于所述转动机构(3)的转动轴向；
    移液头(43)，滑动设置于所述移液滑动座(42)上，用于移送所述检测卡上的试剂，所述移液头(43)的滑动方向平行于所述转动机构(3)的转动轴向；
    第一移液驱动装置(44)，设置于所述移液固定座(41)上，能够带动所述移液滑动座(42)滑动；
    第二移液驱动装置(45)，设置于所述移液滑动座(42)上，能够带动所述移液头(43)滑动。
  7. 根据权利要求6所述的生化分析仪，其特征在于，所述移液机构(4)还包括移液支撑座(46)，所述移液支撑座(46)设置于所述机壳(1)内，用于在移液位置处对所述转动机构(3)进行支撑。
  8. 根据权利要求1所述的生化分析仪，其特征在于，所述出样机构(6)包括：
    出样滑轨(61)，设置于所述机壳(1)内；
    出样支撑座(62)，滑动设置于所述出样滑轨(61)上；
    出样驱动装置(63)，设置于所述机壳(1)内，能够带动所述出样支撑座(62)沿所述出样滑轨(61)滑动，所述出样支撑座(62)滑动时，能够将所述转动机构(3)上的所述检测卡取下并推入所述出样盒(7)内。
  9. 根据权利要求1所述的生化分析仪，其特征在于，所述出样盒(7)包括：
    盒体(71)，用于盛装检测完毕的所述检测卡，滑动设置于所述出样口处，所述盒体(71)上设置有导入口(711)，所述出样机构(6)能够将所述检测卡通过所述导入口(711)导入所述盒体(71)内；
    推动装置(72)，设置于所述机壳(1)内，用于推动所述盒体(71)内的所述检测卡向所述盒体(71)的检测端移动；
    出样检测装置(73)，设置于所述机壳(1)内，所述盒体(71)内的所述检测卡抵靠所述检测端时能够触发所述出样检测装置(73)。
  10. 根据权利要求1-9任一所述的生化分析仪，其特征在于，所述进样口处转动设置有封闭门(11)，进样时，所述进样机构(2)能够推动所述封闭门(11)打开，进样结束后，所述封闭门(11)能够封闭所述进样口。
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