WO2020238601A1 - Procédé et ensemble de prélèvement - Google Patents

Procédé et ensemble de prélèvement Download PDF

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Publication number
WO2020238601A1
WO2020238601A1 PCT/CN2020/089673 CN2020089673W WO2020238601A1 WO 2020238601 A1 WO2020238601 A1 WO 2020238601A1 CN 2020089673 W CN2020089673 W CN 2020089673W WO 2020238601 A1 WO2020238601 A1 WO 2020238601A1
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WO
WIPO (PCT)
Prior art keywords
collection
mixing
tube
collecting
piece
Prior art date
Application number
PCT/CN2020/089673
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English (en)
Chinese (zh)
Inventor
李剑
李亚青
李明锐
孟星宇
吴汉玲
蔡云
Original Assignee
深圳微伴生物有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CN201910464782.7A external-priority patent/CN111879550A/zh
Priority claimed from CN201910888000.2A external-priority patent/CN111879546A/zh
Application filed by 深圳微伴生物有限公司 filed Critical 深圳微伴生物有限公司
Publication of WO2020238601A1 publication Critical patent/WO2020238601A1/fr

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/02—Devices for withdrawing samples

Definitions

  • the present application relates to the technical field of collection devices, and in particular to a collection component and a collection device.
  • stool detection is a routine clinical laboratory test item. In the stool detection process, it is necessary to use a collection spoon or a collection stick to sample the stool.
  • the collection spoon or collection rod with the stool sample needs to be put into the mixing tube, and then the preservation solution is injected into the mixing tube, and the mixing tube is used to Mix the sample with the preservation solution, and then use the mixed solution for testing.
  • the present application provides a collection assembly and a collection device to solve the problems of low collection efficiency and easy spillage of preservation liquid in the prior art.
  • a collection assembly which includes: a collection part provided with a conducting structure, and the collection part is used for collecting samples; and the mixing part has a mixing cavity and a storage liquid cavity that are independently arranged ,
  • the mixing chamber is used to mix the sample and the preservation solution
  • the preservation liquid chamber is used to store the preservation solution; among them, the collection piece has an avoiding position and a conduction position relative to the mixing piece.
  • the collection piece When the collection piece is in the avoiding position, the preservation liquid cavity It is in a sealed state; when the collecting piece is in the conducting position, the conducting structure can conduct the storage liquid cavity with the mixing cavity, so as to conduct the storage liquid in the storage liquid cavity into the mixing cavity.
  • the mixing member includes a mixing tube and a preservation liquid tube connected to each other, the preservation liquid tube has a preservation liquid cavity, and the mixing tube has a mixing cavity.
  • the preservation liquid pipe has a double wall structure
  • the preservation liquid pipe has an inner layer and an outer layer which are arranged oppositely, and there is a gap between the inner layer and the outer layer, and the gap forms a preservation liquid cavity.
  • the preservation liquid chamber has a first end and a second end which are arranged oppositely, the first end of the preservation liquid chamber is arranged close to the collecting member, the first end of the preservation liquid chamber is a closed structure, and the second end of the preservation liquid chamber is an opening Structure, the preservation liquid cavity can be communicated with the mixing cavity through the opening structure.
  • the mixing element further includes: a plugging component, which is arranged at the opening structure, the plugging component is used to close the storage liquid cavity, and the plugging component has a blocked state and an open state.
  • the conducting structure cooperates with the blocking component to switch the blocking component from the blocking state to the open state.
  • the plugging assembly includes: a sealing element arranged at the second end of the preservation liquid chamber; a connecting element arranged at the second end of the preservation liquid chamber; the sealing element seals the opening structure through the connecting element, and the connecting element has a second end arranged oppositely.
  • the sealing position and the first open position, and the conduction structure is used to drive the connecting member to move from the first closed position to the first open position.
  • the connecting member is in the first open position, the storage liquid chamber communicates with the mixing chamber.
  • the connecting piece is clamped on the inner layer, the sealing piece has a ring structure, the outer edge of the sealing piece is connected with the end surface of the outer layer, and the inner edge of the sealing piece is connected with the end surface of the inner layer through the connecting piece.
  • the mixing tube includes a first section and a second section that are connected to each other.
  • the first section of the mixing tube is arranged close to the collecting part, and the cross-sectional size of the first section of the mixing tube is larger than that of the second section of the mixing tube.
  • Cross-sectional size, the preservation solution tube is located in the first section of the mixing tube.
  • the collection piece includes: a body with a holding end and a collection end that are arranged oppositely, the conducting structure is arranged on the body, and the collection end is provided with a collection hole; the solid collection part is arranged at the collection end, and the solid collection part is used for collection. Solid sample; a suction and discharge part, which is arranged on the holding end and communicates with the collection hole, and the suction and discharge part sucks or discharges the liquid sample through the collection hole.
  • a conductive sheet is provided on the side wall of the main body, and the extending direction of the conductive sheet is the same as the axial direction of the main body, and the conductive sheet forms a conductive structure.
  • the collecting piece further includes a collecting head cover, one end of the collecting head cover and the mixing piece is detachably connected, the collecting head cover is provided with an escape hole, and the suction and draining piece partially penetrates the avoiding hole.
  • the solid collection part includes a plurality of convex walls, the plurality of convex walls are arranged at intervals along the circumferential direction of the collection end, and a sample collection area is formed between two adjacent convex walls.
  • a through hole is provided on the surface of at least one convex wall, and the through hole communicates with the sample collection area; and/or the convex wall has a free end and a connecting end that are oppositely arranged, and the connecting end of the convex wall is connected to the side wall of the collection end , The thickness of the free end is less than the thickness of the connecting end; and/or the convex wall is bent in a direction away from the body, and the bending direction of each convex wall is the same.
  • the solid collection part includes: a collection shell sleeved on the collection end, the collection shell has a collection cavity, and the surface of the collection shell is a porous structure.
  • the collection shell has a spherical structure.
  • a collection device includes: a collection component, the collection component being the collection component provided above; a filter component, which is detachably connected to the collection component, and the filter component is used to compare the sample with the preservation solution The mixed liquid is filtered.
  • the filter assembly includes: a filter tube having a first end and a second end that are arranged oppositely; the first end of the filter tube is detachably connected with the mixing tube of the collection assembly; and the filter screen is arranged in the filter tube.
  • the mixing piece of the collection assembly further includes a protective plug.
  • the protective plug is set in the mixing tube and is located close to the outlet of the mixing tube.
  • the protective plug has a second blocking position and a second open position that are relatively disposed. When the protective plug is in the second blocking position, the protective plug blocks the outlet of the mixing tube.
  • the filter tube is provided with a boss, which corresponds to the protective plug. The position between the filter tube and the mixing tube is adjustable. The relative position between the tube and the mixing tube is to use the boss to drive the protective plug to move.
  • the collection device further includes a collection tube, which is detachably connected to the filter assembly, and the collection tube is used to collect the liquid filtered by the filter assembly.
  • the collection component includes a collection part and a mixing part.
  • the collecting piece is provided with a conducting structure, the collecting piece is used for collecting samples, and the collecting piece has an avoiding position and a conducting position relative to the mixing piece.
  • the mixing member By making the mixing member have a mixing cavity and a storage chamber that are set independently of each other, after the collection member is used to complete the sample collection, only the collection member needs to be moved to the conductive position, and the conductive structure on the collection member can be used to
  • the storage solution chamber is connected to the mixing chamber, so that the storage solution in the storage solution chamber can flow into the mixing chamber, so that the sample and the storage solution can be mixed in the mixing chamber.
  • the above device eliminates the need for staff Injecting the preservation solution into the mixing piece can simplify the collection steps, thereby improving the collection efficiency, and the preservation solution will not have the risk of spilling during the inflow process, ensuring the normal mixing of the sample.
  • Figure 1 shows an exploded view of a collection component provided according to an embodiment of the present application
  • Figure 2 shows an exploded view of a collection device according to another embodiment of the present application
  • FIG. 3 shows a schematic diagram of the structure of the preservation liquid tube in FIG. 1;
  • Fig. 4 shows a schematic structural diagram of the filter tube in Fig. 2;
  • Fig. 5 shows another structural schematic diagram of the filter tube in Fig. 2;
  • Figure 6 shows a top view of the filter tube in Figure 2;
  • FIG. 7 shows a schematic diagram of the structure of the solid collecting part in FIG. 1;
  • Fig. 8 shows another schematic diagram of the structure of the solid collecting part in Fig. 1.
  • an embodiment of the present application provides a collection component, which includes a collection part 10 and a mixing part 20.
  • the collecting piece 10 is provided with a conducting structure, and the collecting piece 10 is used for collecting samples.
  • the mixing member 20 has a mixing cavity and a preservation liquid cavity 21 that are independently arranged. The mixing cavity is used for mixing the sample and the preservation solution, and the preservation liquid cavity 21 is used for storing the preservation solution.
  • the collecting member 10 has a avoiding position and a conducting position relative to the mixing member 20.
  • the storage liquid chamber 21 When the collecting member 10 is at the avoiding position, the storage liquid chamber 21 is in a sealed state, and the storage liquid will not spill from the storage liquid chamber 21; When the collecting member 10 is in the conducting position, the conducting structure can conduct the storage liquid chamber 21 and the mixing chamber, so as to conduct the storage liquid in the storage liquid chamber 21 into the mixing chamber. At this time, the sample can be mixed. Mix well with the preservation solution in the homogenizing cavity.
  • the user can use the collection piece 10 to collect a stool sample.
  • the collection piece 10 is located in the avoiding position.
  • the storage liquid chamber 21 is in a sealed state, and the storage liquid will not spill from the storage liquid chamber 21.
  • the user will not come into contact with the preservation liquid, which can improve the safety of the device.
  • the conducting structure on the collecting piece 10 can connect the storage liquid chamber 21 with the mixing chamber, and the storage liquid can be directly connected From the storage liquid chamber 21 into the storage liquid chamber 21 of the mixing member 20, the storage liquid will not spill out.
  • the storage liquid cavity 21 of the mixing member 20 may be integrally formed with the mixing member, or an independent part may be provided, and the storage liquid chamber 21 may be provided in the independent part.
  • the mixing member 20 has an independently arranged part, and a storage liquid chamber 21 is arranged in the part.
  • the mixing member 20 by making the mixing member 20 have a mixing cavity and a storage liquid chamber 21 that are independently arranged, after the collection member 10 is used to complete the sample collection, it is only necessary to move the collection member 10 to conduction. Position, the conductive structure on the collection piece 10 can be used to connect the storage liquid chamber 21 with the mixing chamber, so that the storage liquid in the storage liquid chamber 21 can flow into the mixing chamber, so that the sample and the storage liquid can be The mixing is carried out in the mixing chamber. With the above device, the staff does not need to inject the preservation solution into the mixing part, which can simplify the collection steps, thereby improving the collection efficiency, and the preservation solution will not be spilled during the inflow process. , To ensure the normal mixing of samples.
  • the mixing member 20 includes a mixing tube 22 and a preservation liquid tube 23 connected to each other.
  • the preservation liquid tube 23 has a preservation liquid cavity 21 and the mixing tube 22 has a mixing cavity.
  • the preservation liquid tube 23 can be arranged at one end of the mixing tube 22, or the preservation liquid tube 23 can be directly arranged inside the mixing tube 22.
  • the preservation liquid tube 23 is arranged inside the mixing tube 22.
  • the storage liquid chamber 21 and the mixing chamber can be provided in the mixing tube 22 at the same time, so that the storage liquid tube 23 may not be separately provided, which can simplify the structure of the device and reduce the processing cost. .
  • the preservation liquid pipe 23 has a double-walled structure.
  • the preservation liquid pipe 23 has an inner layer 231 and an outer layer 232 oppositely arranged, and there is a gap between the inner layer 231 and the outer layer 232, which forms the preservation liquid Cavities 21.
  • the collection piece 10 can pass through the inner layer 231 into the mixing cavity of the mixing tube 22.
  • the preservation liquid tube 23 can be used to store the preservation liquid, and the preservation liquid tube 23 will not block the collection piece 10.
  • the preservation liquid pipe 23 has an annular cylindrical structure.
  • the preservation liquid tube 23 may have a semi-annular column shape, a meniscus column shape or other structures.
  • the preservation liquid chamber 21 has a first end and a second end that are arranged oppositely.
  • the first end of the preservation liquid chamber 21 is arranged close to the collecting member 10, and the first end of the preservation liquid chamber 21 is a closed structure, and the preservation liquid will not be spilled from the first end of the preservation liquid chamber 21.
  • the second end of the preservation liquid chamber 21 has an open structure, and the preservation liquid chamber 21 can be communicated with the mixing chamber through the opening structure. Since the second end of the preservation liquid chamber 21 is disposed toward the inside of the mixing tube 22, it is convenient to store. The liquid flows from the preservation liquid chamber 21 into the mixing chamber.
  • the mixing member 20 further includes a plugging component 24, the plugging component 24 is arranged at the opening structure of the storage liquid cavity 21, and the plugging component 24 is used for sealing the storage liquid cavity 21.
  • the blocking component 24 has a blocking state and an open state. When the collecting piece 10 moves from the avoiding position to the conducting position, the conducting structure cooperates with the blocking component 24 to switch the blocking component 24 from the blocking state to In the open state, the storage liquid chamber 21 is connected to the mixing chamber at this time.
  • the blocking component 24 includes a seal, a valve, etc., as long as the blocking component 24 can block the opening structure and switch from the blocked state to the open state.
  • the blocking component 24 includes a sealing member 241 and a connecting member 242.
  • the sealing member 241 and the connecting member 242 are both arranged at the second end of the storage liquid chamber 21, wherein the sealing member 241 seals the opening structure through the connecting member 242, and the shape of the sealing member 241 matches the opening structure of the storage liquid chamber 21,
  • the connecting member 242 has a first blocking position and a first open position that are relatively set. When the collecting member 10 is in the avoiding position, the connecting member 242 is located in the first blocking position. At this time, the storage liquid chamber 21 is blocked by the sealing member 241. Closed structure. Specifically, the conductive structure is used to drive the connecting member 242 from the first blocking position to the first open position. When the collecting member 10 moves to the conductive position, the connecting member 242 is located in the first open position. At this time, the liquid chamber is stored. 21 is connected to the mixing cavity.
  • the connecting member 242 is clamped on the inner layer 231, and the sealing member 241 has a ring structure.
  • the sealing member 241 By connecting the outer edge of the sealing member 241 with the end surface of the outer layer 232, and connecting the inner edge of the sealing member 241 with the end surface of the inner layer 231 through the connecting member 242, the sealing member 241 can be fixed to the second end of the storage liquid chamber 21 , The storage liquid chamber 21 is sealed by the seal 241.
  • the sealing member 241 includes a sealing film, and a clamping boss is provided on the inner wall of the inner layer 231. During the process of assembling the connecting member 242 inside the inner layer 231, the clamping boss can restrict the connecting member 242.
  • the connecting piece 242 When the connecting piece 242 is assembled in place against the clamping boss, that is, the connecting piece 242 is at the first blocking position, and the end of the connecting piece 242 is flush with the end surface of the second end of the storage liquid chamber 21.
  • the sealing film is fixed on the second end of the storage liquid chamber 21 to complete the sealing of the storage liquid chamber 21.
  • the connecting piece 242 When the conductive structure drives the connecting piece 242 to move from the first blocking position to the first open position, the connecting piece 242 is located at the first open position, and the storage liquid chamber 21 is in communication with the mixing chamber at this time.
  • the sealing member 241 includes a transparent film of a certain material or a film of other materials, and the sealing method can be heat-sealed or other methods according to the production process and usage requirements.
  • the mixing tube 22 includes a first section and a second section that are connected to each other.
  • the first section of the mixing tube 22 is disposed close to the collecting member 10, and the cross-sectional size of the first section of the mixing tube 22 is larger than that of the mixing tube.
  • the preservation liquid tube 23 is located in the first section of the mixing tube 22.
  • the storage liquid tube 23 is restricted in position to fix the storage liquid tube 23 to prevent the storage liquid tube 23 from excessively entering the mixing tube 22. Moreover, by making the cross-sectional size of the first section of the mixing tube 22 larger than the cross-sectional size of the second section of the mixing tube 22, on the one hand, it is convenient for the collection piece 10 contaminated with fecal samples to extend into the mixing tube 22 and avoid The stool sample hits the nozzle or the user's hand to enhance the user's collection experience; on the other hand, it is for placing the preservation liquid tube.
  • the collecting member 10 includes a main body 11, a solid collecting part 12 and a suction and discharge member 13.
  • the main body 11 has a holding end and a collection end that are arranged oppositely, the conductive structure is arranged on the main body 11, and the collection end is provided with a collection hole.
  • the solid collecting part 12 can be used to collect solid samples.
  • the suction and discharging member 13 By disposing the suction and discharging member 13 on the holding end and connecting the suction and discharge member 13 with the collection hole, the suction and discharge member 13 sucks or sucks through the collection hole. Discharge the liquid sample.
  • the collection member 10 is suitable for both quantitative collection of solid feces and quantitative collection of liquid feces, thereby improving collection efficiency and meeting the needs of feces collection.
  • the suction and discharge member 13 includes a silicone suction tip.
  • the silica gel tip is a hollow cavity structure, the volume of the hollow cavity can be determined or adjusted by the volume to be sampled, and the solid collection part 12 is used to achieve quantitative collection of samples.
  • the quantitative collection piece can be the above-mentioned integrated dry and wet collection piece, and it can also be divided into dry and wet separation as two collection pieces for design.
  • the size of the silica gel head can be adjusted according to the reagent demand, and it can be in the body according to the needs. Mark or print on the scale.
  • the Bristol stool classification method is a medical classification method for stool.
  • stool is divided into 7 categories, namely: Type 1: Hard balls (difficult to pass); Type 2: Sausage-like, but with uneven surface; Type 3: Sausage-like, but with cracks on the surface; Type 4: Like a sausage or snake, and with a smooth surface; Type 5: Soft block with smooth edges ( Easy to pass); Type 6: thick fluffy lumps, mushy stool; Type 7: watery, without solid lumps (completely liquid).
  • the solid collection part 12 is a wheel-shaped fan blade structure in a clockwise direction on all sides. It is thinner, and the height of the solid collection part 12 and the width of the fan blade can realize the quantification of stool samples.
  • the two wheel-shaped fan blades have parallel small holes in the structure, and the small holes are supplemented by the homogenization operation.
  • the outer periphery of the fan blade is thin or sharp. This design plays an important role in whether the collection piece can collect fecal samples.
  • the direction and angle of the fan blade opening, the number of fan blades, the opening of the fan blade, and the upper The shape, diameter, number of holes, height of the fan blades, etc. can be adjusted accordingly according to actual sampling requirements.
  • samples of types 1-6 are collected, the sample fills the gap of the solid collection part 12, and the quantitative collection of the samples is completed; if the samples of type 7 are collected, the sample can be obtained by squeezing the silicone head with a certain space on the top Since the pressure difference enters the hollow structure of the body 11 through the solid collection part 12, quantitative collection of water-like samples is realized.
  • a conductive sheet 111 is provided on the side wall of the main body 11, and the extending direction of the conductive sheet 111 is the same as the axial direction of the main body 11, and the conductive sheet 111 forms a conductive structure.
  • the side wall of the main body 11 is provided with a plurality of conductive sheets 111, and the plurality of conductive sheets 111 are arranged at intervals along the circumference of the main body 11.
  • the end of the conductive piece 111 away from the suction and discharge member 13 has an arc-shaped structure, which facilitates the conductive piece 111 to drive the connecting member 242 to move.
  • four conductive pieces 111 are provided on the side wall of the main body 11.
  • the collection member 10 further includes a collection head cover 14, and one end of the collection head cover 14 and the mixing member 20 is detachably connected.
  • the collecting head cover 14 is provided with an escape hole, and the suction and discharge member 13 partially penetrates the escape hole.
  • the collecting head cover 14 may be connected to the mixing tube 22 through a threaded structure.
  • the silicone suction head is connected to the main body 11, and the silicone suction head is nested and connected with the collecting head cover 14.
  • the collecting head cover 14 can be assembled with the mixing tube 22 to realize the sealing of the mixing tube 22 and the hand-held part of the collecting piece 10.
  • the solid collection part 12 includes a plurality of convex walls 121, which are arranged at intervals along the circumferential direction of the collection end, and a sample collection area is formed between two adjacent convex walls 121, which can be set according to actual needs.
  • the number of convex walls 121 for example, consists of 3, 5, 8 or 10 convex walls 121, and the space of the collection area can be set to the required size according to needs.
  • the solid collecting portion 12 includes four convex walls 121, and the four convex walls 121 are evenly spaced along the circumferential direction of the collecting end.
  • a through hole 121a is provided on the surface of at least one convex wall 121, and the through hole 121a is in communication with the sample collection area.
  • the through hole 121a is designed as a rectangular small hole, which can also be used according to specific conditions.
  • the through hole 121a is designed as a round hole or other hole type.
  • the through holes 121a may be provided on the spaced convex walls 121 or on all the convex walls 121.
  • two of the four convex walls 121 arranged at intervals are provided with through holes 121a, and each convex wall 121 is provided with three rectangular small holes at intervals along the length direction.
  • the convex wall 121 has a free end 121b and a connecting end 121c that are arranged oppositely, and the connecting end 121c of the convex wall 121 is connected with the side wall of the collecting end.
  • the convex walls 121 are bent in a direction away from the main body 11, and the bending direction of each convex wall 121 is the same.
  • all of the convex walls 121 may be bent in a clockwise direction, all in a counterclockwise direction, or other bending situations.
  • the convex wall 121 forms a wheel-shaped fan blade structure in a clockwise direction.
  • the opening direction, angle and number of the convex wall 121, the shape, diameter, number of holes on the convex wall 121, and the height of the convex wall 121 can be adjusted accordingly according to actual sampling requirements.
  • the mixing element 20 further includes a mixing tube cover 26, and the mixing tube cover 26 is threadedly connected with the other end of the mixing tube 22 opposite to the collecting head cover 14.
  • the mixing member 20 further includes mixing beads 27, which are movably arranged in the mixing tube 22, and the mixing beads 27 can be used to assist in mixing the sample and the preservation solution.
  • the mixing beads 27 include steel beads and glass beads.
  • the mixing ball 27 is a stainless steel ball with a diameter of 5-7 mm.
  • the collection component 10 and the mixing component 20 can be combined into a set, and then placed separately and sent to the user.
  • the collection component is mainly used for mixing and storing the sample.
  • the present application provides another embodiment of the collection assembly.
  • the solid collection part 12 of the collection piece 10 can also adopt the structure design of the collection shell 15, and the collection shell 15 is set in the collection At the end, the collection shell 15 has a collection cavity, and the surface of the collection shell 15 has a porous structure. Set the space of the collection cavity to the required size according to the needs.
  • the collection shell 15 has multiple ribs, and the multiple ribs are staggered, and there are multiple hole-shaped structures between the multiple ribs, so that the collection shell 15 has a porous surface and a certain accommodation space inside. Structure.
  • the collection shell 15 has a spherical structure.
  • the spherical structure of the collection shell 15 does not need to adjust the direction of use of the solid collection part 12, which has the advantage of being convenient to use and can improve collection efficiency.
  • FIG. 2 another embodiment of the present application provides a collection device, which includes a collection component and a filter component 30.
  • the collection component is the collection component provided above
  • the filter component 30 is detachably connected to the collection component
  • the filter component 30 is used to filter the mixed liquid of the sample and the preservation solution.
  • the user can use the collection component to collect samples, and the inspector can use the filter component 30 to filter the mixed liquid of the sample and the preservation solution collected by the user.
  • the filter assembly 30 can be used to filter food residues or other large particle residues in the sample, so as to improve the efficiency of subsequent sample pre-processing and detection.
  • the filter assembly 30 includes a filter tube 31 and a filter mesh 32.
  • the filter tube 31 has a first end and a second end which are arranged oppositely.
  • the first end of the filter tube 31 is detachably connected to the mixing tube 22 of the collection assembly.
  • the filter screen 32 is arranged in the filter tube 31, and the mixed liquid flows through
  • the filter mesh 32 and the filter tube 31 are integrally formed, which can ensure the stability of the device.
  • the filter mesh 32 may be provided as a separate component.
  • the filter assembly 30 can be used to filter the particles larger than the filter diameter in the feces. After the sample is filtered through the structure to filter out the residue of large particles, on the one hand, the preservation effect of the sample in the preservation solution can be improved to a certain extent, and the other On the one hand, it can prevent large particles from clogging the pipette tip and affecting the pipetting gun or pipetting instrument during subsequent testing and sampling.
  • the mixing member 20 of the collection assembly further includes a protective plug 25 which is clamped in the mixing tube 22 and is arranged close to the outlet of the mixing tube 22.
  • a protective plug 25 which is clamped in the mixing tube 22 and is arranged close to the outlet of the mixing tube 22.
  • the boss 33 is set corresponding to the protective plug 25. Since the position between the filter tube 31 and the mixing tube 22 is adjustable, by adjusting the distance between the filter tube 31 and the mixing tube 22 In the relative position of, the protection plug 25 can be driven by the boss 33 to move. When the protection plug 25 moves from the second blocking position to the second open position, the mixing tube 22 and the filter tube 31 are in communication. In addition, by providing the protective plug 25, the mixing tube can be maintained in the vertical direction for replacement during the process of connecting the filter tube by the inspector, and the liquid will not leak out.
  • the protective plug 25 when the protective plug 25 is pushed into the mixing tube, due to the presence of the boss 33, even if centrifugal force is applied to accelerate the sample filtration, it will not cause the protective plug to block the lower nozzle or the filter, thereby blocking the sample. Flow into the filter tube.
  • a push-pull structure can be provided between the filter tube 31 and the mixing tube 22, and the relative position between the filter tube 31 and the mixing tube 22 can be adjusted by using the push-pull structure, or the filter tube 31 and the mixing tube 22 can be threaded Connection, by rotating the filter tube 31 relative to the mixing tube 22, the relative position between the filter tube 31 and the mixing tube 22 can be adjusted.
  • the filter tube 31 and the mixing tube 22 are threadedly connected.
  • the collection device further includes a collection tube 40, the collection tube 40 is detachably connected to the filter assembly 30, and the collection tube 40 is used to collect the liquid filtered by the filter assembly 30.
  • the collection tube 40 and the second end of the filter tube 31 are detachably connected.
  • the collection tube 40 is threadedly connected to the second end of the filter tube 31.
  • a one-dimensional code or two-dimensional code can be printed on the bottom and sides of the filter tube 31 and/or the rear collection tube 40 for sample information tracking and recording.
  • the tube cover of the collection tube 40 can be a grooved hexagon, and the bottom of the tube can be hexagonal or hexagonal, so that the structure of the cover and the bottom of the tube can be fixed by the corresponding opening instrument and realize automatic opening of the instrument.
  • the bottom of the tube is tapered, which is convenient for processing and taking biological samples.
  • the preservation liquid tube 23 By arranging the preservation liquid tube 23 in the mixing tube 22 and providing a conducting structure on the collection piece 10, the preserving liquid cavity 21 of the preserving liquid tube 23 and the mixing cavity of the mixing tube 22 can be connected by the conducting structure In this way, the preservation solution can be combined with the sample during the process of combining the collection element 10 and the mixing element 20, which can improve the sampling efficiency and reduce the risk of contamination of the preservation solution caused by the user's contact with the preservation solution.
  • orientation words such as “front, back, up, down, left, right", “horizontal, vertical, vertical, horizontal” and “top, bottom”, etc. indicate the orientation Or positional relationship is usually based on the positional or positional relationship shown in the drawings, which is only used to facilitate the description of the present invention and simplify the description. Unless otherwise stated, these positional words do not indicate or imply the pointed device or element It must have a specific orientation or be constructed and operated in a specific orientation, so it cannot be understood as a limitation of the protection scope of the present invention; the orientation word “inside and outside” refers to the inside and outside relative to the contour of each component itself.
  • spatially relative terms such as “above”, “above”, “above”, “above”, etc. can be used here to describe as shown in the figure. Shows the spatial positional relationship between one device or feature and other devices or features. It should be understood that the spatially relative terms are intended to encompass different orientations in use or operation other than the orientation of the device described in the figure. For example, if the device in the figure is inverted, then the device described as “above the other device or structure” or “above the other device or structure” will then be positioned as “below the other device or structure” or “on Under other devices or structures”. Thus, the exemplary term “above” can include both orientations “above” and “below”. The device can also be positioned in other different ways (rotated by 90 degrees or in other orientations), and the relative description of the space used here is explained accordingly.
  • the collection component includes a collection part and a mixing part.
  • the collecting piece is provided with a conducting structure, the collecting piece is used for collecting samples, and the collecting piece has a avoiding position and a conducting position relative to the mixing piece.
  • the mixing member By making the mixing member have a mixing cavity and a storage chamber that are set independently of each other, after the collection member is used to complete the sample collection, only the collection member needs to be moved to the conductive position, and the conductive structure on the collection member can be used to
  • the storage solution chamber is connected to the mixing chamber, so that the storage solution in the storage solution chamber can flow into the mixing chamber, so that the sample and the storage solution can be mixed in the mixing chamber.
  • the above device eliminates the need for staff Injecting the preservation solution into the mixing piece can simplify the collection steps, thereby improving the collection efficiency, and the preservation solution will not have the risk of spilling during the inflow process, ensuring the normal mixing of the sample.

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  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Sampling And Sample Adjustment (AREA)

Abstract

L'invention concerne un ensemble et un dispositif de prélèvement, qui peuvent résoudre les problèmes de l'état de la technique de faible efficacité de prélèvement de déversement fréquent d'un liquide de conservation. L'ensemble de prélèvement comprend : un élément de prélèvement (10) pourvu d'une structure de communication, l'élément de prélèvement (10) étant utilisé pour acquérir un échantillon ; et un élément de mélange uniforme (20) doté d'une chambre de mélange uniforme et d'une chambre de liquide de conservation (21) qui sont disposées indépendamment l'une de l'autre, la chambre de mélange uniforme étant utilisée pour mélanger uniformément l'échantillon et un liquide de conservation, et la chambre de liquide de conservation (21) étant utilisée pour stocker le liquide de conservation ; l'élément de prélèvement (10) présente une position de retrait et une position de communication par rapport à l'élément de mélange uniforme (20), et lorsque l'élément de prélèvement (10) se trouve dans la position de retrait, la chambre de liquide de conservation (21) est dans un état scellé, et lorsque l'élément de prélèvement (10) est dans la position de communication, la structure de communication peut permettre la communication entre la chambre de liquide de conservation (21) et la chambre de mélange uniforme, de façon à permettre au liquide de conservation dans la chambre de liquide de conservation (21) d'entrer dans la chambre de mélange uniforme.
PCT/CN2020/089673 2019-05-30 2020-05-11 Procédé et ensemble de prélèvement WO2020238601A1 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
CN201910464782.7 2019-05-30
CN201910464782.7A CN111879550A (zh) 2019-05-30 2019-05-30 采集件以及采集装置
CN201910888000.2A CN111879546A (zh) 2019-09-19 2019-09-19 采集组件以及采集装置
CN201910888000.2 2019-09-19

Publications (1)

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WO2020238601A1 true WO2020238601A1 (fr) 2020-12-03

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Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20160338678A1 (en) * 2015-05-20 2016-11-24 Alpha-Tec Systems, Inc. Sample collection apparatus
CN207007540U (zh) * 2017-06-18 2018-02-13 张巍巍 一次性采便器
CN207483746U (zh) * 2017-12-05 2018-06-12 广东南芯医疗科技有限公司 一种粪菌样本保护装置
CN207528471U (zh) * 2017-11-14 2018-06-22 上海市杨浦区中心医院 新型粪便采集处理器
CN207567226U (zh) * 2017-12-28 2018-07-03 广东南芯医疗科技有限公司 一种微生物样本保护装置
CN208171631U (zh) * 2018-06-14 2018-11-30 广州新诚生物科技有限公司 样品采样装置及其包装体

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20160338678A1 (en) * 2015-05-20 2016-11-24 Alpha-Tec Systems, Inc. Sample collection apparatus
CN207007540U (zh) * 2017-06-18 2018-02-13 张巍巍 一次性采便器
CN207528471U (zh) * 2017-11-14 2018-06-22 上海市杨浦区中心医院 新型粪便采集处理器
CN207483746U (zh) * 2017-12-05 2018-06-12 广东南芯医疗科技有限公司 一种粪菌样本保护装置
CN207567226U (zh) * 2017-12-28 2018-07-03 广东南芯医疗科技有限公司 一种微生物样本保护装置
CN208171631U (zh) * 2018-06-14 2018-11-30 广州新诚生物科技有限公司 样品采样装置及其包装体

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