WO2020238150A1 - 一种在体闭环灭菌设备 - Google Patents

一种在体闭环灭菌设备 Download PDF

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Publication number
WO2020238150A1
WO2020238150A1 PCT/CN2019/124726 CN2019124726W WO2020238150A1 WO 2020238150 A1 WO2020238150 A1 WO 2020238150A1 CN 2019124726 W CN2019124726 W CN 2019124726W WO 2020238150 A1 WO2020238150 A1 WO 2020238150A1
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Prior art keywords
blood
irradiated
light
pipeline
equipment according
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PCT/CN2019/124726
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English (en)
French (fr)
Inventor
刘忠英
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刘忠英
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Publication of WO2020238150A1 publication Critical patent/WO2020238150A1/zh

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3681—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits by irradiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3693—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits using separation based on different densities of components, e.g. centrifuging
    • A61M1/3696—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits using separation based on different densities of components, e.g. centrifuging with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation

Definitions

  • the present invention relates to the field of medical equipment, and more specifically, the present invention relates to an in-vivo closed-loop sterilization device.
  • blood light therapy has been more and more widely used. Specifically, a certain amount of blood is collected from the human body to the outside of the body, and the collected blood is transported to a blood radiation therapy instrument for ultraviolet light irradiation treatment, and the blood is reinfused into the body after the treatment is completed.
  • blood phototherapy has obvious advantages, but it also has certain problems in long-term application: First, this method can only treat a small amount of blood, and the treatment effect is often very unsatisfactory. ; Second, this method is an intermittent treatment that needs to be separated from the body. Because it is an external treatment and then reinfused into the body, it is more troublesome to operate, and it is easy to cause blood contamination or infection in this process, which is safer low. It can be seen that it is very necessary to study new sterilization or virus killing equipment or equipment.
  • An object of the present invention is to provide a new technical solution for in-vivo closed-loop sterilization equipment.
  • an in-vivo closed-loop sterilization equipment including a blood collection device, a cell centrifugal separation device, a light sterilization device, and a reinfusion device;
  • the light sterilization device includes a light device and a device to be irradiated, The device to be irradiated is made of transparent material;
  • the blood sampling device is connected to the cell centrifugal separation device through a first pipeline;
  • the cytocentrifugation device is configured to separate blood into a non-treatment part and a part to be treated; the cytocentrifugation device is connected to the reinfusion device through a second pipeline; the cytocentrifugation device also passes through a Three pipelines are connected to the device to be irradiated, the device to be irradiated is configured to receive the part to be treated, and the lighting device is configured to perform treatment on the portion to be treated received in the device to be irradiated Light exposure
  • the device to be irradiated is also connected to the return device through a fourth pipeline;
  • the blood collection device, the cell centrifugal separation device, the illumination device, and the reinfusion device are respectively connected to the control device.
  • the in-vivo closed-loop sterilization equipment further includes a collection device, and the collection device is connected to the third pipeline;
  • the collection device has an injection port that is connected to the drug injection device, and the collection device is configured to collect in advance the portion to be treated in the blood separated by the cell centrifugal separation device.
  • the medicine injection device is a syringe; or,
  • the medicine injection device is a medicine injection pump, and the medicine injection pump is connected to the control device.
  • the lighting device includes two oppositely arranged light panels, and at least one of the two opposite surfaces of the two light panels is provided with a plurality of illuminating light sources;
  • the device to be illuminated is arranged between the two lamp panels.
  • the device to be irradiated is a blood bag
  • the swing mechanism is made of a light-transmitting material, and the blood bag is arranged on the swing mechanism;
  • the illuminating light source is lamp beads or lamp tubes.
  • the device to be irradiated is a blood cartridge
  • the blood box includes a flat box body, and a light-transmitting blood flow channel is arranged in the box body;
  • the illuminating light source is lamp beads, and the arrangement of a plurality of lamp beads on the lamp board matches the shape of the blood flow channel.
  • the device to be irradiated is a blood cartridge
  • the blood box includes a flat box body, the box body is respectively provided with a feed inlet and a discharge port, the box body is provided with a plurality of partitions, and the plurality of partitions divide the space in the box A plurality of accommodating cavities, each accommodating cavity is provided with a feed branch port communicating with the feed port, and each accommodating cavity is also provided with a feed branch port communicating with the discharge port;
  • the illuminating light source is lamp beads, a plurality of lamp beads are arranged in multiple rows and multiple columns on the lamp panel, and the lamp beads in two adjacent rows are staggered; or,
  • the illumination light source is a lamp tube, and a plurality of lamp tubes are arranged in sequence on the lamp panel to form at least one row of lamp tubes.
  • the device to be irradiated is a blood transfusion tube, and a section of the blood transfusion tube extending between the two light plates has a flat structure.
  • the illumination device includes a cylindrical shell with open ends, and a plurality of illumination light sources are uniformly arranged on the inner wall of the cylindrical shell;
  • the device to be irradiated is arranged inside the cylindrical casing.
  • the device to be irradiated is a blood tube.
  • the device to be irradiated is a blood pipeline
  • the cross-sectional size of a section of the blood pipeline is larger than the cross-sectional size of the two ends of the section, and a fluid divider is provided in this section, A flow channel is formed between the inner wall and the outer wall of the fluid distribution;
  • the separating fluid is made of a light-transmitting material, and the separating fluid is configured to flow the part to be treated along the shunt flow channel when the part to be treated enters the blood pipeline.
  • the distributing fluid is a hollow structure.
  • a flow control pump is provided on the blood pipeline, and the flow control pump is connected to the control device.
  • the cylindrical shell is installed on a section of the blood pipeline where the fluid separation is provided by a bayonet or a hinge.
  • a pressure sensor is provided outside the blood sampling device and the reinfusion device, and the pressure sensor is connected to the control device.
  • the cell centrifugal separation device is connected with a component detection device, the component detection device is connected with a control device, and the component detection device is configured to detect the centrifugal separation of the cells under the control of the control device.
  • the type, purity and layered state of each part separated by the device is not limited to, but not limited to, but not limited to, but not limited to, but not limited to, but not limited to, but not limited to, but not limited to, the component detection device, the component detection device is connected with a control device, and the component detection device is configured to detect the centrifugal separation of the cells under the control of the control device.
  • the type, purity and layered state of each part separated by the device is not limited to the type, purity and layered state of each part separated by the device.
  • the reinfusion device is also connected to an ultrasonic bubble sensor and a fluid replacement device respectively, and the ultrasonic bubble sensor and the fluid replacement device are both connected to the control device.
  • the in-vivo closed-loop sterilization equipment provided by the embodiments of the present invention can form a closed-loop system with the human body during use.
  • the in-vivo closed-loop equipment can continue to work, and after separating specific components of blood in the whole body, it can continuously and targeted
  • the part to be treated is treated with light irradiation, which has the characteristics of good treatment effect and high efficiency, which can effectively eliminate bacteria and viruses in the blood and treat other suitable diseases.
  • the entire treatment environment is safe and can avoid the occurrence of infection.
  • the in-body closed-loop sterilization equipment has a simple structure and convenient operation.
  • Fig. 1 is a schematic structural diagram of the first in-vivo closed-loop sterilization equipment provided by an embodiment of the present invention.
  • Fig. 2 is a schematic structural diagram of a second in-vivo closed-loop sterilization equipment provided by an embodiment of the present invention.
  • Fig. 3 is a schematic structural diagram of a third in-vivo closed-loop sterilization equipment provided by an embodiment of the present invention.
  • Fig. 4 is a schematic structural diagram of a fourth in-vivo closed-loop sterilization equipment provided by an embodiment of the present invention.
  • Fig. 5 is a schematic structural diagram of a first light sterilization device provided by an embodiment of the present invention.
  • Fig. 6 is a schematic structural diagram of a second light sterilization device provided by an embodiment of the present invention.
  • Fig. 7 is a schematic structural diagram of a third light sterilization device provided by an embodiment of the present invention.
  • Fig. 8 is a structural exploded view of a blood cartridge and a corresponding light board provided by an embodiment of the present invention.
  • Fig. 9 is a structural exploded view of another blood cartridge and corresponding light board provided by an embodiment of the present invention.
  • Fig. 10 is a schematic structural diagram of a fourth light sterilization device provided by an embodiment of the present invention.
  • Fig. 11 is a partial enlarged schematic view of Fig. 10.
  • Fig. 12 is a schematic structural diagram of a fifth light sterilization device provided by an embodiment of the present invention.
  • Fig. 13 is a side view of Fig. 12.
  • Fig. 14 is a schematic diagram of the internal structure of Fig. 12.
  • Fig. 15 is a schematic structural diagram of a blood pipeline provided by an embodiment of the present invention.
  • Figure 16 is a schematic structural diagram of another blood tube provided by an embodiment of the present invention.
  • Fig. 17 is a side view of Fig. 15.
  • Fig. 18 is a side view of a lighting device provided by an embodiment of the present invention.
  • Fig. 19 is a side view of another lighting device provided by an embodiment of the present invention.
  • the in-vivo closed-loop sterilization equipment provided by the embodiments of the present invention can form a closed-loop system with the body during use.
  • the in-vivo closed-loop sterilization equipment can work continuously and can be used for continuous circulatory light irradiation treatment on the blood of the patient’s whole body.
  • the treatment environment is safe and reliable, and can effectively avoid blood infections.
  • the “in-body” refers to being connected with the body to form a whole body.
  • the "closed loop” refers to the formation of a closed system between the entire blood processing equipment and the body to avoid the intrusion of external bacteria and the like, and to avoid infection and danger.
  • the in-vivo closed-loop sterilization equipment provided by the embodiments of the present invention can be applied to humans, animal bodies, etc., which is not limited by the present invention.
  • the in-vivo closed-loop sterilization equipment at least includes: a blood sampling device 1, a cell centrifugal separation device 2, a light sterilization device, a reinfusion device 5, and a medicine injection device.
  • a control device 6 may also be included to realize automatic control of the entire equipment.
  • the blood collection device 1 of the present invention may include a blood collection needle, a blood collection pump, a filter, a blood collection tube and other components well known to those skilled in the art, which will not be described in detail here.
  • the blood sampling device 1 can be connected to the cell centrifugal separation device 2 through the first pipe 8.
  • the blood sampling pump under the action of the blood sampling pump, the blood drawn from the body can pass through the first tube
  • the path 8 is conveyed to the cell centrifugal separation device 2.
  • the blood collection device 1 is used to collect blood from the body and send the collected blood into the cell centrifugal separation device 2.
  • the blood sampling device 1 can be connected to the control device 6 through a communication control line, that is, the control device 6 can control the start and stop operations of the blood sampling device 1.
  • the cell centrifugal separation device 2 of the present invention mainly separates blood based on the principle of centrifugal separation, so as to divide the blood into different parts.
  • the cell centrifugal separation device 2 is used to separate the blood into a non-treatment part and a treatment part, so as to treat the separated part to be treated to inactivate bacteria and viruses therein.
  • bacteria it exists in the plasma of the blood but not in the cells. Therefore, the plasma in the blood can be separated separately by the cytocentrifugal separation device 2 and used as the part to be treated.
  • the light sterilization device alone performs light irradiation treatment on the plasma to eliminate the bacteria present in the plasma.
  • the virus it may exist in plasma and nucleated cells. Therefore, the plasma and nucleated cells can be separated from the blood by centrifugal separation, and then the separated plasma and nucleated cells can be treated by a light sterilization device. Nuclear cells undergo light irradiation treatment to inactivate the viruses contained in them.
  • the cell centrifugal separation device 2 can be connected to the control device 6 through a communication control line, that is, the control device 6 can realize reasonable control of the centrifugal separation process of the cell centrifugal separation device 2.
  • the cell centrifugal separation device 2 of the present invention relies on the principle of centrifugation to separate blood components, and its centrifugal part can be, for example, a centrifugal plate, a centrifugal bag, a centrifugal cup, etc., which can be flexibly selected according to specific conditions. There is no restriction on this.
  • the illumination sterilization device of the present invention includes an illumination device 4 and a device 3 to be irradiated, and the device 3 to be irradiated is made of light-transmitting material as a whole.
  • the illumination device 4 can generate irradiation treatment light with a predetermined intensity and duration, and the irradiation treatment light can be used for light irradiation treatment.
  • the device 3 to be irradiated can be used to receive the portion to be treated in the blood separated by the cell centrifugal separation device 2.
  • the whole device 3 to be irradiated is made of light-transmitting material, the irradiation treatment light emitted by the illumination device 4 can pass through the device 3 to be irradiated to perform light irradiation treatment on the part to be treated inside, that is, to The part to be treated is sterilized and virus-killed.
  • the irradiation treatment light emitted by the illumination device 4 can be selected from any one of UVA, UVB, UVC, and visible light or a combination of all of them, which can be flexibly selected according to specific conditions, which is not limited in the present invention.
  • a specific irradiation energy J (irradiation joule) and a specific irradiation wavelength should be selected so as to prevent damage to nucleated cells when the virus is inactivated.
  • the cell centrifugal separation device 2 can be connected to the reinfusion device 5 through the second pipeline 9 for sending the non-treatment part separated from the blood directly into the return device 5 through the second pipeline 9 and It is returned to the body by the return device 5 to realize a cyclic process.
  • the cell centrifugal separation device 2 is also connected to the device to be irradiated 3 through a third pipeline 10, and the device to be irradiated 3 is connected to the infusion device 5 through a fourth pipeline 11.
  • the part to be treated separated from the blood can be sent into the device to be irradiated 3 through the third pipeline 10, and the light irradiation treatment is performed by the illumination device 4 on the part to be treated in the irradiating device 3, and the light irradiation is to be completed After the treatment, it is sent to the infusion device 5 and returned to the body by the infusion device 5 to realize another circulation process.
  • the above whole process can be performed continuously until the whole body blood is treated one or more times, which can be flexibly adjusted according to the actual situation, which is not limited by the present invention.
  • the cytocentrifugal separation device 2 when the cytocentrifugal separation device 2 sends the separated treatment part into the device 3 to be irradiated, it is necessary to inject a photosensitizer or related treatment drugs into the third pipeline 10 from the drug injection device.
  • a photosensitizer or related treatment drugs during treatment can enhance the therapeutic effect.
  • vitamin B2 with no toxic and side effects can be used, but whether it is necessary to cooperate with drugs is determined by clinical conditions, and the present invention does not limit this.
  • the in-vivo closed-loop sterilization equipment provided by the embodiment of the present invention may further include a collection device 17.
  • the collection device 17 can be connected or arranged on the third pipe 10 connecting the cell centrifugal separation device 2 and the device 3 to be irradiated.
  • the collection device 17 has an injection port, which can be connected to a medicine injection device.
  • the medicine injection device can inject the photosensitizer or related therapeutic drugs into the collection device 17 through the injection port.
  • the part to be treated in the blood separated by the cell centrifugal separation device 2 can be transported to the collection device 17 for collection.
  • the photosensitizer (or medicine) is injected into the collection by the injection device through the injection port.
  • the part to be treated mixed with the photosensitizer (or medicine) is sent into the device to be irradiated 3, and the light irradiation device 4 performs light irradiation treatment, After the light irradiation treatment is completed, it is sent to the reinfusion device 5 through the fourth pipeline 11, and is finally infused back into the body.
  • the lighting device 4 is turned on at this time. In this manner, after the part to be treated in the collecting device 17 is completely input to the device 3 to be irradiated, the newly separated part to be treated is input into the collecting device 17.
  • This method has the characteristics of convenient and simple control.
  • the transmission speed can be determined by the control device 6 according to the irradiation energy and the irradiation intensity of the illumination device 4.
  • the collection device 17 may be, for example, a storage device such as a storage bag or a storage pool, which can be flexibly selected according to needs during use, which is not limited in the present invention.
  • the in-vivo closed-loop sterilization equipment provided by the embodiment of the present invention may not be provided with the collection device 17.
  • the portion to be treated in the blood separated by the cell centrifugation device 2 When transmitting to the device 3 to be irradiated, the light device 4 performs light irradiation treatment on the transmitted part to be treated, that is, the transmission and the light irradiation treatment are performed simultaneously.
  • the medicine injection device of the present invention can adopt a medicine injection pump 7 which can be connected to the control device 6 through a communication control line.
  • a medicine injection pump 7 which can be connected to the control device 6 through a communication control line.
  • the drug injection pump 7 injects the photosensitizer (or medicine) into the collection device 17, it can be synchronized in time with the transmission of the portion to be treated by the cell centrifugal separation device 2 to the collection device 17.
  • the amount of photosensitizer (or drug) injected can be precisely controlled. The above whole process can realize automatic processing with high accuracy and very convenient operation.
  • the medicine injection device of the present invention may also be a syringe 18.
  • the syringe 18 is manually operated, and the photosensitizer (or medicine) can be injected into the third pipeline 10 through the syringe 18, or into the collection device 17, which can be set flexibly according to whether the collection device 17 is provided.
  • the reinfusion device 5 may include blood transfusion needles, blood transfusion pumps, filters, blood transfusion tracts and other components well known to those skilled in the art, which will not be described in detail here.
  • the combination of the reinfusion device 5 and the blood sampling device 1 can realize a closed loop circulation process in the body.
  • the return device 5 in order to realize automatic control (for example, start or stop) of the operation of the return device 5, the return device 5 can be connected to the control device 6 through a communication control line, and the control device 6 realizes the control of the return device. 5 The work process is reasonably controlled.
  • the blood sampling device 1, the cell centrifugal separation device 2, the light sterilization device, and the reinfusion device 5 can be controlled respectively by the control device 6.
  • the control device 6 may have a display device, and the user can control and observe the working status of each component by operating the display device.
  • the display device may be, for example, a display device known to those skilled in the art such as a touch screen, which is not limited in the present invention.
  • the in-vivo closed-loop sterilization equipment provided by the embodiment of the present invention may also adopt a single needle mode, that is, the blood sampling device 1 and the reinfusion device 5 are combined together.
  • the control device 6 can control the blood sampling and reinfusion alternately.
  • a needle can be used, which can serve as a blood sampling needle or a blood transfusion needle.
  • the needle is connected to the pipeline, and when blood is collected from the body, blood will not be returned to the body for transfusion, that is, blood collection and transfusion work in a time-sharing manner, and there will be no mutual interference.
  • the control device 6 controls the blood sampling pump to operate, and at the same time controls the return pump to stop working (or small flow).
  • the blood sampling pump When the blood is returned, the blood sampling pump is controlled to stop by the control device 6 (the flow rate is 0 when stopped, which is equivalent to closing the pipeline and the operation of the return pump is controlled at the same time).
  • the flow rate of the blood sampling pump is greater than the flow rate of the infusion pump, blood flows outward from the needle, and vice versa.
  • first pipeline 8, the second pipeline 9, the third pipeline 10, and the fourth pipeline 11 all use hoses well known to those skilled in the art to facilitate the transportation of blood.
  • size of the above-mentioned pipelines can be flexibly adjusted as required, which is not limited by the present invention.
  • the light sterilization device of the present invention has a simple and diverse structure and can meet various needs.
  • the light sterilization device includes a light device 4 and a device 3 to be irradiated.
  • the illumination device 4 of the present invention may include a housing, and a plurality of irradiation light sources 402 are arranged on the inner wall of the housing, and the irradiation light source 402 emits irradiation treatment light to realize light irradiation treatment.
  • the irradiation light source 402 may be any one of UVA, UVB, UVC, and visible light or a combination of all of them.
  • the device 3 to be irradiated is arranged inside the housing, so that the irradiation light source 402 can irradiate the device 3 to be irradiated, so that the part to be treated in the device 3 to be irradiated can be treated with light irradiation.
  • the housing of the illuminating device 4 can have various structures, which can be flexibly selected according to actual conditions in the application.
  • the number and arrangement of the illuminating light sources 402 can also be flexibly adjusted as required.
  • the illuminating light source 402 can be directly arranged on the inner wall of the housing, or embedded in the inner wall of the housing, and then protected by a transparent cover.
  • a structure of the lighting device 4 includes a housing, and the housing includes two light panels 401 arranged opposite to each other.
  • a plurality of illuminating light sources 402 are uniformly arranged on two opposite surfaces of the two lamp boards 401, respectively.
  • the device 3 to be irradiated is arranged between the two lamp panels 401.
  • the irradiation light sources 402 on the two lamp panels 401 can irradiate the upper and lower surfaces of the irradiation device 3 with light.
  • the simultaneous up and down light irradiation can make the irradiated device 3 to be irradiated evenly receive light, so that the internal part to be treated can receive good light irradiation treatment uniformly.
  • a plurality of illumination light sources 402 may be uniformly arranged on any one of the two opposite surfaces of the two lamp panels 401, that is, a single-sided light irradiation mode is formed.
  • the illuminating light source 402 can be a lamp bead or a lamp tube, which can be flexibly adjusted according to actual needs in specific applications.
  • the device 3 to be irradiated can adopt any of the following structures.
  • the device 3 to be irradiated is a blood bag made of a light-transmitting material.
  • a swing mechanism 19 can be added to it.
  • the light source for illuminating the blood bag can be lamp beads or lamp tubes, and the lamp beads or lamp tubes are uniformly distributed on the light board 401, for example, arranged in a matrix shape.
  • the swing mechanism 19 may adopt a swing plate, and the blood bag can be directly placed on the swing plate when in use.
  • the swing mechanism 19 can be made of a material with good light transmission properties such as quartz, of course, it can also be other light transmission materials well known to those skilled in the art.
  • the present invention does not do this. limit.
  • the device 3 to be irradiated is a blood cartridge with a flat structure.
  • the blood cartridge has at least two different structures. The following further describes two blood cartridges with different structures.
  • the blood cartridge includes a flat box body, and a light-transmitting blood flow channel 301 is provided in the box body.
  • the illumination light source 402 can choose to use lamp beads, and the arrangement of the plurality of lamp beads on the lamp board 401 should match the shape of the blood flow channel 301.
  • the blood flow channel 301 in the blood cartridge has a certain width and a very thin wall, and has good light permeability, which is convenient for irradiating light into it, so as to realize light irradiation treatment on the part to be treated flowing in the blood flow channel.
  • the arrangement of a plurality of lamp beads along the shape of the blood flow channel 301 is beneficial to align the blood flow channel 301 with sufficient light irradiation treatment, and can make full use of light energy and avoid the waste of light energy.
  • multiple lamp beads can also be arranged in other ways on the lamp board 401, for example, a plurality of lamp beads are evenly arranged to form a matrix shape, etc., which can be flexibly adjusted according to specific needs, as long as the lamp beads can illuminate the blood flow channel 301 Within.
  • the blood cartridge includes a flat box body, the box body is provided with a feed port 303, a feed port 304, and is provided with A plurality of partitions are used to divide the space in the box into a plurality of accommodating cavities, wherein each accommodating cavity is provided with a feed branch port 305 communicating with the feed port 303, and each container The cavity is also provided with a discharge branch port 306 communicating with the discharge port 304.
  • the illuminating light source 402 can be a lamp bead or a lamp tube.
  • lamp beads when lamp beads are used, a plurality of lamp beads are arranged in multiple rows and multiple columns on the lamp board 401, and the lamp beads in two adjacent rows are staggered to make full use of light energy.
  • a lamp tube When a lamp tube is used, a plurality of lamp tubes are arranged in sequence on the lamp panel to form one or more rows of lamp tubes.
  • the lamp tubes can also be arranged into other shapes, such as rectangles, according to the needs of illumination.
  • a turn may be provided on the baffle plate. The turn is designed according to the fluid curve and can be used for diversion to facilitate the flow of fluid and prevent the formation of a dead angle. In addition, it is more preferable that a plurality of partitions are evenly arranged in the blood cartridge at equal distances.
  • the diameter of the feed branch port 305 closer to the feed port 303 is smaller than that of the far feed branch port 305, that is
  • the feed branch port gradually increases in diameter from the end close to the feed port to the far end, which facilitates the flow of fluid into each accommodating cavity respectively, so that the part to be treated can be partitioned for light irradiation treatment and improve the light treatment effect.
  • the device 3 to be irradiated is a blood vessel.
  • the blood vessel is inserted between the two light plates 401.
  • two opposing surfaces of the two light plates 401 are respectively provided with a row of illuminating light sources 402 corresponding to the position of the blood vessel. This method simplifies the structure of the lighting device 4.
  • the blood transfusion tube when a blood transfusion tube is used, the blood transfusion tube can be extended into the lighting device 4, that is, a section extending between the two light plates 401 is made into a flat structure to increase the light receiving Area, which can appropriately improve the effect of light irradiation treatment.
  • the blood tube can be directly processed into a flat structure.
  • the part of the blood transfusion tube that needs to be irradiated can be formed into a flat structure by squeezing.
  • the blood transfusion tube is usually made of relatively soft material. When squeezing it, two light plates 401 can be used to directly squeeze it. Of course, other extrusion methods can also be used.
  • a light-transmitting support frame can be arranged in the blood vascular tube to keep the blood vascular tube flat without affecting the light transmission.
  • a structure of the illumination device 4 is as follows: includes a shell, and the shell is a cylindrical shell 403 with open ends. At this time, a plurality of illumination light sources 402 are uniformly arranged in a cylindrical shape. On the inner wall of the housing 403. Under this structure, the device 3 to be irradiated extends into the interior of the cylindrical housing 403, for example, can be arranged along the central axis of the cylindrical housing 403, that is, the device 3 to be irradiated can be wrapped by the cylindrical housing 403 , So that the device to be irradiated 3 receives light from the irradiation light source 402 in the cylindrical housing 403. Wherein, the illuminating light source 402 can be a lamp bead or a lamp tube, which can be flexibly selected according to specific conditions.
  • the device 3 to be irradiated can use a common blood tube, and its cross-sectional shape can be round, oval, etc., which is not limited by the present invention.
  • the blood tubing is usually relatively thin, with an inner diameter of about 1.5-4 mm.
  • the illumination device 4 When light is irradiated to it by the illumination device 4, the light-receiving area is relatively small, which may lead to unsatisfactory light-irradiation treatment effects.
  • a method of increasing the radius of the blood line can be adopted.
  • the cross-sectional size of a section of the blood pipeline is larger than the cross-sectional size of the two ends of the section, and a fluid divider 302 is provided in the section of the blood pipeline.
  • a shunt flow channel 308 is formed between the inner wall of the blood pipeline and the outer wall of the fluid 302.
  • the fluid distribution 302 includes a fluid distribution housing, and the fluid distribution housing has a cavity, that is, a hollow structure.
  • the fluid divider 302 is made of light-transmitting material as a whole, so that the radiation treatment light emitted by the illumination device 4 can pass through.
  • the branch fluid 302 is configured to: when the part to be treated separated from the blood enters the blood pipeline, the part to be treated is a fluid, which can be used to flow the part to be treated along the shunt flow channel, even if the part to be treated is attached to the blood The wall of the pipeline passes.
  • the illumination device 4 is used to illuminate it, it has the characteristics of large light receiving area and more uniform light receiving.
  • the fluid divider 302 can also be a solid structure, but its weight is heavier compared to a hollow structure. In specific applications, it can be flexibly adjusted as required.
  • the outer shape of the fluid distribution housing should help the fluid to flow smoothly. That is, while realizing the diversion, it also has a good diversion function, which is beneficial to realize the flow without dead ends.
  • the shape of the fluid distribution housing can be a cube shape, a conical cylinder shape, etc., wherein the conical cylinder refers to a cylinder whose two ends form a triangular shape.
  • the cylindrical shell 403 can be designed as two semicircular structures, and the bayonet pins 404 are respectively arranged at the junction of the two semicircular structures, and the cylinder The shaped shell 403 is clamped on the blood pipeline.
  • the cylindrical housing 403 can also be designed as an openable and closable structure. After opening, the cylindrical housing 403 is installed on the blood tube, and then fixed by a hinge 405. The above two methods can be flexibly selected according to needs, and the present invention does not limit this.
  • the lamp bead on the inner wall of the cylindrical housing 403 can be provided with a lamp shade; of course, it is also possible not to add a lamp shade, that is, the lamp beads directly Shine outward.
  • a flow control pump 307 can also be provided on the blood line.
  • the flow control pump 307 can be connected to the control device 6 through a communication control line.
  • the flow control pump 307 can be controlled by the control device 6 to control the flow rate of the fluid input into the blood line.
  • the in-vivo closed-loop sterilization equipment provided by the embodiment of the present invention may also include an anticoagulant adding device 13.
  • the anticoagulant adding device 13 is configured to add an anticoagulant to the blood sampling device 1. Specifically, when the blood sampling device 1 draws blood out and sends it into the first pipeline 8 and starts to circulate, the anticoagulant can be added to prevent the blood being processed from clotting, thereby ensuring the smooth progress of the entire blood circulation process. It should be noted that the addition amount of the anticoagulant can be flexibly controlled according to needs, which is not limited in the present invention.
  • the anticoagulant adding device 13 can be directly combined with the blood sampling device 1.
  • the anticoagulant adding device 13 can also be connected to the blood sampling device 1 through a pipe. Both of these two methods can realize the addition of anticoagulant, which can be flexibly selected according to the actual situation in specific applications.
  • the anticoagulant adding device 13 can also be connected to the control device 6 through a communication control line.
  • This design can realize the control of the anticoagulant adding device 13 by the control device 6, that is, it can control the anticoagulant adding device 13 to add an anticoagulant to the blood or stop adding an anticoagulant to the blood.
  • the automatic control of the addition of the anticoagulant can be realized by the control device 6, which is more convenient to operate and easy to control the addition amount.
  • the anticoagulant adding device 13 may not be connected to the control device 6. At this time, the addition and the amount of the anticoagulant can be manually controlled. In specific applications, it can be flexibly selected according to needs, which is not limited in the present invention.
  • the in-vivo closed-loop sterilization equipment provided by the embodiment of the present invention further includes a pressure sensor 12.
  • pressure sensors 12 may be provided outside the blood sampling device 1 and the reinfusion device 5, respectively.
  • the pressure sensors 12 are all connected to the control device 6 through a communication control line. In order to achieve accurate pressure detection, the pressure sensor 12 must be close to the corresponding pipeline when it is installed.
  • the pressure sensor 12 provided outside the blood sampling device 1 is used to detect the blood sampling end, such as the pressure of the blood sampling tube in the blood sampling device, and the pressure in the first pipeline 8 connected to the blood sampling device 1.
  • the pressure sensor 12 provided outside the reinfusion device 5 is used to detect the reinfusion end, such as the pressure in the blood transfusion channel in the reinfusion device 5, and the second pipeline 9 and the fourth pipeline connected to the reinfusion device 5 The pressure in the pipeline 11.
  • the pressure detection can determine whether the needle (for example, blood sampling needle, blood transfusion needle) and the corresponding pipeline are blocked. Once blockage occurs, it is easy to cause abnormal pressure in the pipe and cause danger.
  • the pressure sensor 12 there are multiple positions for the pressure sensor 12, which are not limited to the manner in the above-mentioned embodiment.
  • the pressure sensors 12 are respectively arranged on corresponding pipelines.
  • the pressure sensor 12 is arranged inside the corresponding pipeline. It can be flexibly adjusted according to the actual situation, and the present invention does not limit this.
  • the present invention does not specifically limit the number of pressure sensors 12 installed, and an appropriate number can be flexibly selected according to needs.
  • each pressure sensor 12 can be connected to the control device 6 through a communication control line.
  • This design can realize the control of the pressure sensor 12 by the control device 6, that is, the pressure sensor 8 can be controlled to start pressure detection at an appropriate time, and of course, the pressure sensor 12 can also be controlled not to perform pressure detection.
  • the in-vivo closed-loop sterilization equipment provided by the embodiment of the present invention may also include a component detection device 16.
  • the component detection device 16 can be connected to the cell centrifugal separation device 2 through a detection line or a communication control line, and the component detection device 16 is also connected to the control device 6 through a detection line or a communication control line.
  • the component detection device 16 is configured to detect the components and purity of each part separated by the cell centrifugation device 2 under the control of the control device 6, and the component detection device 16 can also be used for the cell centrifugation device 2
  • the separation process of the components is controlled so that different components can form a good layered state, which is conducive to the separate extraction of different components.
  • the component detection device 16 can detect the layered state, type, and purity of each component. It should be noted that the component detection device 16 can be set or not set as required.
  • the in-vivo closed-loop sterilization equipment provided by the embodiment of the present invention further includes an ultrasonic bubble sensor 15, which is located at one end of the return device 5.
  • the ultrasonic bubble sensor 15 is connected to the return device 5.
  • the ultrasonic bubble sensor 15 uses ultrasound to detect whether the returned blood contains bubbles. Once it detects that the blood contains bubbles, immediately stop the infusion of blood into the body and give an alarm. Otherwise, the blood entering the body will be dangerous.
  • the ultrasonic bubble sensor 15 is also connected to the control device 6 through a communication control line.
  • This design can realize the control of the ultrasonic bubble sensor 15 by the control device 6, that is, the ultrasonic bubble sensor 15 can be controlled to start the detection at an appropriate time, and of course, the ultrasonic bubble sensor 15 can also be controlled not to perform detection. In other words, the automatic control of the ultrasonic bubble sensor 15 can be realized by the control device 6.
  • the in-vivo closed-loop sterilization equipment provided by the embodiment of the present invention may further include a fluid supplement device 14.
  • the fluid replacement device 14 is configured to replenish fluid into the blood when returning blood, for example, it can replenish nutrient solution or medicine into the body.
  • the fluid replacement device 14 can be connected to the reinfusion device 5 through a fluid replacement tube.
  • the fluid replacement device 14 can also be combined with the reinfusion device 5. Both of the above-mentioned methods can realize the addition of nutrient solution or medicine to the returned blood.
  • the fluid replacement device 14 may be connected to the control device 6 through a communication control line. This design can realize the control of the control device 6 to the fluid replacement device 14 to realize the automation of fluid replacement.
  • the anticoagulant adding device 13 and the liquid supplementing device 14 in the present invention can be dedicated pumps, and their operation or stopping can be controlled by the control device 6.
  • the pressure sensor 12, the ultrasonic bubble sensor 15, and the component detection device 16 in the present invention are also controlled by the control device 6, which realizes the automation of operation.

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Abstract

一种在体闭环灭菌设备，包括采血装置（1）、细胞离心分离装置（2）、光照灭菌装置、回输装置（5）和注药装置（7）；光照灭菌装置包括光照装置（4）和待照射装置（3），待照射装置（3）由透光材料制成；采血装置（1）通过第一管路（8）与细胞离心分离装置（2）连接；细胞离心分离装置（2）被配置为用于将血液分成非治疗部分和待治疗部分；细胞离心分离装置（2）通过第二管路（9）与回输装置（5）连接；细胞离心分离装置（2）还通过第三管路（10）与待照射装置（3）连接，待照射装置（3）被配置为用于接收待治疗部分，光照装置（4）被配置为用于对待照射装置（3）内接收的待治疗部分进行光照射；待照射装置（3）还通过第四管路（11）与回输装置（5）连接；注药装置（7）与第三管路（10）连接。该在体闭环灭菌设备能实现对全身血液的循环照射治疗。

Description

一种在体闭环灭菌设备 技术领域
本发明涉及医疗器械领域，更具体地，本发明涉及一种在体闭环灭菌设备。
背景技术
在日常的生活中，人体很有可能会由于各种原因而感染上细菌或者病毒，从而引发各种疾病，严重时甚至还会危及到人们的生命。目前，常用的治疗方法为：采用抗生素类药物进行抗菌治疗，或者是，采用抗病毒类药物进行抗病毒治疗。但是，药物治疗大多会带来一定的副作用，而且长期使用药物后身体也会产生一定的抗药性。因此，不宜大剂量或长时间使用药物进行治疗。另外，对于医院存在的一些超级细菌，目前尚没有较为有效的抗菌药物对其进行有效的治疗。
随着医学科技的快速发展，血液光照疗法得到越来越广泛的应用。具体来说，是从人体采集一定量的血液到体外，并将采集到的血液输送到血液辐射治疗仪中接受紫外光照射治疗，待治疗完成之后再重新将血液回输到人体内。虽然，比起药物治疗，血液光照疗法具有很明显的优势，但是在长期的应用中发现其也存在一定的问题：第一，该方法只能对少量的血液进行治疗，治疗效果往往非常不理想；第二，这种方式是间断性治疗，需要与身体分离开来，由于是体外治疗再重新输回体内，操作起来比较麻烦，而且在这一过程中容易引发血液污染或者感染，安全性较低。可见，非常有必要研究新的灭菌或灭病毒设备或者设备。
发明内容
本发明的一个目的在于提供一种在体闭环灭菌设备的新技术方案。
根据本发明的一个方面，提供了一种在体闭环灭菌设备，包括采血装 置、细胞离心分离装置、光照灭菌装置和回输装置；所述光照灭菌装置包括光照装置和待照射装置，所述待照射装置由透光材料制成；
所述采血装置通过第一管路与所述细胞离心分离装置连接；
所述细胞离心分离装置被配置为用于将血液分成非治疗部分和待治疗部分；所述细胞离心分离装置通过第二管路与所述回输装置连接；所述细胞离心分离装置还通过第三管路与所述待照射装置连接，所述待照射装置被配置为用于接收所述待治疗部分，所述光照装置被配置为用于对所述待照射装置内接收的待治疗部分进行光照射；
所述待照射装置还通过第四管路与所述回输装置连接；
还包括注药装置，所述注药装置与所述第三管路连接。
可选地，所述采血装置、细胞离心分离装置、光照装置、回输装置分别与控制装置连接。
可选地，所述的在体闭环灭菌设备，还包括收集装置，所述收集装置连接在所述第三管路上；
所述收集装置具有注入口，所述注入口与所述注药装置连接，所述收集装置被配置为：用于预先收集经所述细胞离心分离装置分离出的血液中的待治疗部分。
可选地，所述注药装置为注射器；或者是，
所述注药装置为注药泵，所述注药泵与控制装置连接。
可选地，所述光照装置包括两个相对设置的灯板，所述两个灯板相对的两个面中至少有一个面上设置有多个照射光源；
所述待照射装置设置在所述两个灯板之间。
可选地，所述待照射装置为血袋；
还包括摆动机构，所述摆动机构由透光材料制成，所述血袋设置在所述摆动机构上；
所述照射光源为灯珠或者灯管。
可选地，所述待照射装置为血液盒；
所述血液盒包括扁平状的盒体，所述盒体内设置有透光的血液流道；
所述照射光源为灯珠，多个灯珠在灯板上排列方式与所述血液流道的 形状相匹配。
可选地，所述待照射装置为血液盒；
所述血液盒包括扁平状的盒体，所述盒体上分别设置有进料口、出料口，所述盒体内设置有多个隔板，所述多个隔板将盒体内的空间分成多个容置腔，每个容置腔均设置有与所述进料口连通的进料分支口，每个容置腔还设置有与所述出料口连通的出料分支口；
所述照射光源为灯珠，多个灯珠在灯板上呈多行多列排布，且相邻两行的灯珠呈相互错开设置；或者是，
所述照射光源为灯管，多个灯管在灯板上依次排列，形成至少一排灯管。
可选地，所述待照射装置为输血管道，且所述输血管道伸入所述两个灯板之间的一段呈扁平状结构。
可选地，所述光照装置包括两端开口的圆筒状壳体，在所述圆筒状壳体的内壁上均匀设置有多个照射光源；
所述待照射装置设置在所述圆筒状壳体的内部。
可选地，所述待照射装置为血液管路。
可选地，所述待照射装置为血液管路，所述血液管路其中一段的横截面尺寸大于该段两端部的横截面尺寸，且在该段内设置有分流体，血液管路的内壁与分流体的外壁之间形成分流流道；
所述分流体采用透光材料制成，所述分流体被配置为：当待治疗部分进入血液管路内，用于使待治疗部分沿着所述分流流道流过。
可选地，所述分流体为中空结构。
可选地，所述血液管路上设置有流量控制泵，所述流量控制泵与控制装置连接。
可选地，圆筒状壳体通过卡销或者合页安装在所述血液管路设置有所述分流体的一段上。
可选地，所述采血装置和所述回输装置的外部分别设置有压力传感器，所述压力传感器与控制装置连接。
可选地，所述细胞离心分离装置连接有成分检测装置，所述成分检测 装置与控制装置连接，所述成分检测装置被配置为：在所述控制装置的控制下检测经所述细胞离心分离装置分离出的各部分的种类，纯度以及分层状态。
可选地，所述回输装置还分别连接超声气泡传感器、补液装置，所述超声气泡传感器、补液装置均与控制装置连接。
本发明实施例提供的在体闭环灭菌设备，在使用时可以与人体形成闭环系统，该在体闭环设备可以持续工作，通过对全身血液的特定成分分离后，可连续的、针对性的对其中的待治疗部分进行光照射治疗，具有治疗效果好和效率高的特点，能有效消灭血液中的细菌、病毒，以及治疗其它相适应的病症。整个治疗环境安全，能避免感染情况的发生。该在体闭环灭菌设备的结构简单，操作也比较方便。
通过以下参照附图对本发明的示例性实施例的详细描述，本发明的其它特征及其优点将会变得清楚。
附图说明
被结合在说明书中并构成说明书的一部分的附图示出了本发明的实施例，并且连同其说明一起用于解释本发明的原理。
图1是本发明实施例提供的第一种在体闭环灭菌设备的结构示意图。
图2是本发明实施例提供的第二种在体闭环灭菌设备的结构示意图。
图3是本发明实施例提供的第三种在体闭环灭菌设备的结构示意图。
图4是本发明实施例提供的第四种在体闭环灭菌设备的结构示意图。
图5是本发明实施例提供的第一种光照灭菌装置的结构示意图。
图6是本发明实施例提供的第二种光照灭菌装置的结构示意图。
图7是本发明实施例提供的第三种光照灭菌装置的结构示意图。
图8是本发明实施例提供的一种血液盒和对应的灯板的结构分解图。
图9是本发明实施例提供的另一种血液盒和对应的灯板的结构分解图。
图10是本发明实施例提供的第四种光照灭菌装置的结构示意图。
图11是图10的局部放大示意图。
图12是本发明实施例提供的第五种光照灭菌装置的结构示意图。
图13是图12的侧视图。
图14是图12的内部结构示意图。
图15是本发明实施例提供的一种血液管路的结构示意图。
图16是本发明实施例提供的另一种血液管路的结构示意图。
图17是图15的侧视图。
图18是本发明实施例提供的一种光照装置的侧视图。
图19是本发明实施例提供的另一种光照装置的侧视图。
附图标记说明：
1-采血装置，2-细胞离心分离装置，3-待照射装置，301-血液流道，302-分流体，303-进料口，304-出料口，305-进料分支口，306-出料分支口，307-流量控制泵，308-分流流道，4-光照装置，401-灯板，402-照射光源，403-圆筒状壳体，404-卡销，405-合页，5-回输装置，6-控制装置，7-注药泵，8-第一管路，9-第二管路，10-第三管路，11-第四管路，12-压力传感器，13-抗凝剂添加装置，14-补液装置，15-超声气泡传感器，16-成分检测装置，17-收集装置，18-注射器，19-摆动机构。
具体实施方式
现在将参照附图来详细描述本发明的各种示例性实施例。应注意到：除非另外具体说明，否则在这些实施例中阐述的部件和步骤的相对布置、数字表达式和数值不限制本发明的范围。
以下对至少一个示例性实施例的描述实际上仅仅是说明性的，决不作为对本发明及其应用或使用的任何限制。
对于相关领域普通技术人员已知的技术、方法和设备可能不作详细讨论，但在适当情况下，所述技术、方法和设备应当被视为说明书的一部分。
在这里示出和讨论的所有例子中，任何具体值应被解释为仅仅是示例性的，而不是作为限制。因此，示例性实施例的其它例子可以具有不同的值。
应注意到：相似的标号和字母在下面的附图中表示类似项，因此，一旦某一项在一个附图中被定义，则在随后的附图中不需要对其进行进一步 讨论。
本发明实施例提供的在体闭环灭菌设备，在使用时可以与身体形成闭环系统，该在体闭环灭菌设备可以连续进行工作，可用于对患者全身的血液进行连续的循环光照射治疗，以灭活其中的细菌、病毒，以及其它相适应的病症，治疗环境安全、可靠，能有效避免血液感染的情况发生。需要说明的是，在本发明中，所述“在体”是指与身体连接在一起形成一体。所述“闭环”是指整个血液处理设备与身体形成一个封闭系统，以避免外部细菌等侵入，避免感染而造成危险。另外，本发明实施例提供的在体闭环灭菌设备可应用于人体、动物体等，本发明对此不作限制。
参考图1所示，本发明实施例提供的在体闭环灭菌设备，其至少包括：采血装置1，细胞离心分离装置2，光照灭菌装置，回输装置5，以及注药装置。当然，还可以包括控制装置6，以实现对整个设备的自动化控制。
本发明的采血装置1可以包括采血针、采血泵、过滤器以及采血管等本领域技术人员熟知的部件，在此不再具体说明。在本发明中，参考图1所示，采血装置1可以通过第一管路8与细胞离心分离装置2连接，此时，在采血泵的作用下，从身体抽取出的血液可以经第一管路8输送到细胞离心分离装置2中。也就是说，采血装置1用于从身体抽取血液并将抽取的血液送入细胞离心分离装置2内。并且，为了实现对采血装置1运行的自动化控制，可以将采血装置1通过通讯控制线与控制装置6连接在一起，即可以由控制装置6实现对采血装置1启动、停止等操作的控制。
本发明的细胞离心分离装置2主要是基于离心分离原理对血液进行分离处理，以将血液分成不同的部分。在本发明中，细胞离心分离装置2是用于将血液分成非治疗部分和待治疗部分，以便于针对分离出的待治疗部分进行治疗，以灭活其中的细菌、病毒。具体来说，对于细菌而言，它存在于血液的血浆中，而不存在于细胞内，因此，可以通过细胞离心分离装置2将血液中的血浆单独分离出来，将其作为待治疗部分，之后再由光照灭菌装置单独对血浆进行光照射治疗，即可消灭血浆中存在的细菌。而对于病毒而言，在血浆和有核细胞内都有可能会存在，因此，可以通过离心分离从血液中分离出血浆、有核细胞，之后再由光照灭菌装置对分离出的血浆、有核细胞进行 光照射治疗，以灭活其中所含有的病毒。
其中，细胞离心分离装置2可以通过通讯控制线与控制装置6连接在一起，即可以通过控制装置6实现对细胞离心分离装置2离心分离过程进行合理的控制。
另外，需要说明的是，本发明的细胞离心分离装置2为依靠离心原理对血液成分进行分离，其离心部分例如可以为离心盘、离心袋、离心杯等，可以根据具体情况灵活选择，本发明对此不作限制。
参考图1所示，本发明的光照灭菌装置，其包括有光照装置4和待照射装置3，且待照射装置3整体采用透光材料制成。具体来说，光照装置4可产生预定强度和持续时间的照射治疗光，该照射治疗光可用于进行光照射治疗。而待照射装置3可用于接收经细胞离心分离装置2分离出的血液中的待治疗部分。由于待照射装置3整体采用透光材料制作而成，因此，光照装置4发射出的照射治疗光可以透过待照射装置3而对其内部的待治疗部分进行光照射治疗，即对血液中的待治疗部分进行灭菌、灭病毒处理。
其中，光照装置4发射出的照射治疗光可以选用UVA，UVB、UVC、可见光中的任意一种或其所有的组合，可以根据具体情况灵活选择，本发明对此不作限制。
其中，光照装置4可以通过通讯控制线与控制装置6连接在一起，即可以由控制装置6对光照装置4的光照强度和时间等进行合理的控制。具体来说，控制装置6可以按照治疗要求对光照装置4的照射时间和照射强度等进行控制。实际上，在光照装置4进行光照射的过程中，照射能量J(单位，焦耳)＝W*t，其中，W为照射功率，t为照射时间。需要说明的是，在利用光照装置4进行光照射治疗的过程中，要选择特定的照射能量J(照射焦耳)、特定照射波长，这样在灭活病毒时，可以防止对有核细胞造成损伤。
本发明中，细胞离心分离装置2可以通过第二管路9与回输装置5连接，用于将从血液中分离出的非治疗部分直接经第二管路9送入回输装置5，并由回输装置5回输到体内，以实现一个循环过程。并且，细胞离心分离装置2还通过第三管路10与待照射装置3连接，待照射装置3通过第四管路11与回输装置5连接。此时，可以将从血液中分离出的待治疗部分经 第三管路10送入待照射装置3内，由光照装置4对待照射装置3内的待治疗部分进行光照射治疗，待完成光照射治疗后再将其送到回输装置5，并由回输装置5送回体内，以实现另一个循环过程。以上整个过程可以连续进行，直到将全身血液治疗一遍或者多遍，具体可以根据实际情况灵活调整，本发明对此不作限制。
其中，细胞离心分离装置2将分离出的治疗部分送入待照射装置3内时，需要由注药装置向第三管路10中同步注入光敏剂或者相关的治疗药物。在治疗时使用光敏剂或者相关的治疗药物，能够增强治疗效果。例如，可以采用无毒副作用的维生素B2，但是否需要配合药物由临床根据情况确定，本发明对此不作限制。
参考图2以及图3所示，本发明实施例提供的在体闭环灭菌设备，还可以包括收集装置17。其中，收集装置17可以连接或设置在连通细胞离心分离装置2和待照射装置3的第三管道10上。
收集装置17具有注入口，该注入口可以与注药装置连接。注药装置可以将光敏剂或者相关的治疗药物经注入口注入到收集装置17内。经细胞离心分离装置2分离出的血液中的待治疗部分可以先输送到收集装置17内进行收集，当积累达到一定容量后，由注药装置将光敏剂(或者药物)通过注入口注入到收集装置10，待光敏剂(或者药物)与待治疗部分充分混合之后，再将混有待光敏剂(或者药物)的待治疗部分送入待照射装置3内，并由光照装置4进行光照射治疗，待光照射治疗完成后由第四管路11送到回输装置5，最终输回到体内。
当收集装置17中收集的待治疗部分被全部输送到待照射装置3之后，此时再开启光照装置4。在这种方式下，在收集装置17内的待治疗部分完全输入到待照射装置3后，再向收集装置17内输入新分离出的待治疗部分。该方式具有控制方便、简单的特点。
收集装置17将待治疗部分传输到待照射装置3的过程中，传输速度可以由控制装置6根据光照装置4的照射能量和照射强度确定。
收集装置17例如可以是保存袋或者存储池等具有存储功能的装置，在使用中可以根据需要灵活选择，本发明对此不作限制。
可选的是，参考图1所示，本发明实施例提供的在体闭环灭菌设备也可以不设置收集装置17，此时，经细胞离心分离装置2分离出的血液中的待治疗部分一边向待照射装置3传输，一边由光照装置4对传输的待治疗部分进行光照射治疗，即传输和光照射治疗同步进行。采用一边传输一边照射的方式时，光照装置4的照射时间t＝L/v，其中，L为待照射装置3传输长度，v为传输速度。该方式具有治疗效率高的特点。
参考图1以及图2所示，本发明的注药装置可以采用注药泵7，该注药泵7可以通过通讯控制线与控制装置6连接。在控制装置6的控制下，注药泵7在向收集装置17内注入光敏剂(或者药物)时，可以实现在时间上与细胞离心分离装置2向收集装置17传输待治疗部分的同步。而且，所注入光敏剂(或者药物)的量可以精密控制。以上的整个过程可以实现自动处理，精度较高，且操作非常方便。
参考图3所示，本发明的注药装置也可以为注射器18。由人工操作注射器18，通过注射器18可以将光敏剂(或者药物)注入第三管路10，或者注入收集装置17内，具体可以根据是否设置收集装置17而灵活设置。
其中，回输装置5可以包括输血针、输血泵、过滤器以及输血管道等本领域技术人员熟知的部件，在此不再具体说明。回输装置5与采血装置1相配合可以实现在体闭环循环过程。并且，在本发明中，为了实现对回输装置5运行的自动化控制(例如启动或者停止)，可以将回输装置5通过通讯控制线与控制装置6连接，由控制装置6实现对回输装置5的工作过程进行合理控制。
本发明中，可以通过控制装置6实现对采血装置1、细胞离心分离装置2、光照灭菌装置、以及回输装置5等分别进行相应的控制。通过该设计可以使在体闭环灭菌设备具有自动化控制的特点。其中，可选的是，控制装置6可以具有显示装置，用户可以通过操作显示装置来控制和观察各部件的工作状态等。其中，显示装置例如可以是触摸式显示屏等本领域技术人员熟知的显示装置，本发明对此不作限制。
另外，参考图4所示，本发明实施例提供的在体闭环灭菌设备，还可以采用单针模式，即将采血装置1与回输装置5合并在一起。此时，可以 通过控制装置6控制采血与回输交替进行。具体来说：可以采用一个针，该针可以充当采血针，也可以充当输血针。将该针连接管路，当从体内采血的时候不会向体内回输血，即采血与输血是分时进行工作的，不会产生相互之间的干扰现象。在进行采血时，由控制装置6控制采血泵进行运转，同时控制回输泵停止工作(或小流量)。在回输血液时，由控制装置6控制采血泵停转(停止时流量为0，相当于管路关闭，同时控制回输泵运转)。其中，采血泵的流量大于回输泵流量时，血液自针向外流，反之向体内流。
需要说明的是，所述的第一管路8、第二管路9、第三管路10、第四管路11均采用本领域技术人员熟知的软管，以便于血液的输送。并且，上述这些管路的尺寸可以根据需要灵活调整，本发明对此不作限制。
本发明的光照灭菌装置，结构简单、多样，可以适合多种需求。该光照灭菌装置包括光照装置4和待照射装置3。
本发明的光照装置4，其可以包括外壳，且在该外壳的内壁上设置有多个照射光源402，由照射光源402发射出照射治疗光，以实现光照射治疗。其中的照射光源402可以选用UVA，UVB、UVC、可见光中的任意一种或其所有的组合。在使用时，待照射装置3被设置在该外壳的内部，以便于照射光源402能照射到待照射装置3，从而能对待照射装置3内的待治疗部分进行光照射治疗。
需要说明的是，光照装置4的外壳可以具有多种结构，在应用中可以根据实际情况灵活选择。照射光源402的设置数量和排列方式也可以根据需要灵活调整。另外，照射光源402可以直接设置在外壳的内壁上，也可以嵌入到外壳的内壁中，再采用透光的罩壳保护起来。
参考图5所示，光照装置4的一种结构为：包括外壳，该外壳包括相对设置的两个灯板401。在两个灯板401相对的两个面上分别均匀设置有多个照射光源402。待照射装置3被设置在两个灯板401之间。此时，两个灯板401上的照射光源402可以对待照射装置3的上、下面进行光照射。采用上下同时光照射可以使被照射的待照射装置3均匀受光，从而可以使内部的待治疗部分均匀接受良好的光照射治疗。需要说明的是，也可以是两个灯板401相对的两个面中任一个面上均匀设置多个照射光源402，即 形成单面光照射的方式。
其中，照射光源402可以为灯珠或者灯管，在具体应用中可以根据实际需要灵活调整。
当光照装置4的外壳为两个相对设置的灯板401时，待照射装置3可采用以下的任一种结构。
可选的是，待照射装置3为由透光材料制成的血袋。参考图6所示，为了使血袋中收集的待治疗部分都能均匀受光，即接收的光照能量相同，可以为其增设摆动机构19。此时，照射血袋的照射光源可以采用灯珠，也可以采用灯管，且灯珠或者灯管在灯板401上呈均匀分布，例如排列成矩阵的形状。具体地，摆动机构19可以采用摆动板，在使用时将血袋直接平放置在摆动板上即可。需要说明的是，为了能实现良好的透光效果，摆动机构19可以采用例如石英等透光性好的材料制作，当然也可以是本领域技术人员熟知的其它透光材料，本发明对此不作限制。
可选的是，参考图7所示，待照射装置3为扁平状结构的血液盒。该血液盒至少具有两种不同的结构。以下进一步说明两种不同结构的血液盒。
在本发明的一个具体实施方式中，参考图8所示，血液盒包括扁平状的盒体，且在该盒体内设置有透光的血液流道301。此时，照射光源402可以选择采用灯珠，且多个灯珠在灯板401上排列方式应当与该血液流道301的形状相匹配。其中，血液盒中的血液流道301具有一定的宽度且壁非常薄，透光性很好，便于将光照射到其中，实现对血液流道中流动的待治疗部分进行光照射治疗。其中，将多个灯珠沿血液流道301的形状排布，有利于对准血液流道301进行充分光照射治疗，可以充分利用光能，避免光能的浪费。当然，多个灯珠在灯板401上也可以采用其它的排布方式，例如多个灯珠均匀排列形成矩阵形等，可以根据具体需要灵活调整，只要使灯珠能照射到血液流道301内即可。
在本发明的另一个具体实施方式中，参考图9所示，血液盒包括扁平状的盒体，该盒体上分别设置有进料口303、出料口304，且在该盒体内设置有多个隔板，多个隔板用于将盒体内的空间分成多个容置腔，其中，每个容置腔均设置有与进料口303连通的进料分支口305，且每个容置腔还 设置有与出料口304连通的出料分支口306。此时，照射光源402可以采用灯珠，也可以采用灯管。具体来说：当采用灯珠时，多个灯珠在灯板401上呈多行多列排布，且相邻的两行的灯珠呈相互错开设置，以充分利用光能。当采用灯管时，多个灯管在灯板上依次排列，形成一排或者多排灯管，当然灯管也可以根据照射需要排列成其它的形状，例如矩形等。
当从血液中分离出的待治疗部分由进料口303进入血液盒内，由于待治疗部分为流体，可以通过各个进料分支口305进入不同的容置腔内。由于流体流通面积变大，其受光的面积也就加大。在本实施例中，可以在隔板上设置转弯，该转弯按照流体曲线设计，可以用于导流，便于使流体流出，以防止形成死角。另外，较为优选的是，多个隔板在血液盒内呈等距离均匀设置，此时，距进料口303近的进料分支口305的口径小于远的进料分支口305的口径，即进料分支口从距离进料口近的一端到远的一端，口径逐渐变大，利于流体分别向各个容置腔内流通，从而能将待治疗部分分区进行光照射治疗，提高光照治疗效果。
可选的是，待照射装置3为输血管道。进行照射治疗时，将该输血管道伸入到两个灯板401之间。此时，两个灯板401相对的两个面上对应于输血管道的位置各设置一排照射光源402。该方式简化了光照装置4的结构。
参考图10以及图11所示，当采用输血管道时，可以将输血管道伸入光照装置4中，即伸入到两个灯板401之间的一段制成扁平状的结构，以增大受光面积，这样可以适当的提高光照射治疗效果。其中，可以将血液管道直接加工成扁平状结构。或者是，采用挤压的方式使输血管道需要接受照射的部分形成扁平状结构。需要说明的是，输血管道通常材质比较软，在对其进行挤压处理时，可以采用两个灯板401直接对其进行挤压，当然也可以采用其它的挤压方式。而为了防止输血管道形变的恢复，可以在输血管道内设置透光的支撑架，在不影响透光的同时，可以使输血管道保持扁平状。
参考图12-图14所示，光照装置4的一种结构为：包括外壳，其外壳为两端开口的圆筒状壳体403，此时，多个照射光源402被均匀设置在圆 筒状壳体403的内壁上。在该结构下，待照射装置3伸入圆筒状壳体403的内部，例如可以沿圆筒状壳体403的中心轴线设置，即通过圆筒状壳体403可以将待照射装置3包裹起来，以使待照射装置3在圆筒状壳体403内接受照射光源402的光照射。其中，照射光源402可以为灯珠，也可以为灯管，可以根据具体情况灵活选择。
当光照装置4的外壳为圆筒状结构时，为了配合其结构，待照射装置3可以选用普通的血液管路，其截面形状可以为圆形、椭圆形等，本发明对此不作限制。
但是，通常血液管路比较细，内径约为1.5-4mm，通过光照装置4对其进行光照射时，受光面积比较小，会导致光照射治疗效果不理想。而为了增加受光面积，提高光照射效果可以采用增大血液管路半径的方式。在一个具体的实施方式中，参考图15-图17所示，血液管路其中一段的横截面尺寸大于该段两端部的横截面尺寸，且在该段血液管路内设置有分流体302，此时，血液管路的内壁与分流体302的外壁之间形成了分流流道308。
其中，分流体302包括分流体壳体，该分流体壳体内具有空腔，即为中空结构。并且，分流体302整体采用透光材料制成，可以使光照装置4发射出的照射治疗光穿过。分流体302被配置为：当从血液中分离出的待治疗部分进入血液管路内，待治疗部分为流体，可用于使待治疗部分沿着分流流道流过，即使待治疗部分贴着血液管路的壁面通过。当采用光照装置4对其进行光照射时，具有受光面积大，以及受光更均匀的特点。当然，分流体302也可以为实心结构，只是相比于中空结构而言，其重量较重。在具体应用中，可以根据需要灵活调整。
需要说明的是，分流体壳体的外部形状应当有助于使流体可以顺利流过。即在实现分流的同时，还兼具良好的导流功能，有利于实现无死角流动。参考图15和16所示，分流体壳体的形状可以为立方体状、锥形圆柱体状等，其中锥形圆柱体是指两端形成三角状的圆柱体。
为了使血液管路能稳定的设置在光照装置4的圆筒状壳体403内部，可以采用将圆筒状壳体403固定在待照射的血液管路上的方式。参考图18所示，可以将圆筒状壳体403设计为两个半圆形的结构，并在两个半圆形 结构的连接处分别设置卡销404，通过一对卡销404将圆筒状壳体403卡接在血液管路上。参考图19所示，还可以将圆筒状壳体403设计为可开合的结构，打开后将圆筒状壳体403安装在血液管路上，之后通过合页405将其固定住。上述两种方式可以根据需要灵活选择，本发明对此不作限制。需要说明的是，当采用如图18和图19中的这种方式时，圆筒状壳体403的内壁上的灯珠可以加设灯罩；当然，也可以不加设灯罩，即灯珠直接向外照射。
另外，参考图16所示，还可以在血液管路上设置流量控制泵307。该流量控制泵307可以通过通讯控制线与控制装置6连接。可以通过控制装置6对流量控制泵307进行控制，以控制输入到血液管路中流体的流速。
参考图1-图4所示，本发明实施例提供的在体闭环灭菌设备，还可以包括抗凝剂添加装置13。其中，该抗凝剂添加装置13被配置为：可以向采血装置1中添加抗凝剂。具体来说，当采血装置1将血液抽取出来送入第一管路8内并开始进行循环时，通过添加抗凝剂可以防止正在处理的血液凝固，从而能保证整个血液循环过程的顺利进行。需要说明的是，抗凝剂的添加量可以根据需要灵活控制，本发明对此不作限制。
其中，抗凝剂添加装置13可以与采血装置1直接结合在一起。当然，抗凝剂添加装置13也可以通过管道与采血装置1连接。这两种方式均可以实现抗凝剂的添加，在具体的应用中，可以根据实际情况灵活选择。
并且，抗凝剂添加装置13还可以通过通讯控制线与控制装置6连接。该设计可以实现控制装置6对抗凝剂添加装置13的控制，即可以控制抗凝剂添加装置13向血液中添加抗凝剂，或者停止向血液中添加抗凝剂。也就是说，可以通过控制装置6实现对抗凝剂添加的自动控制，这种方式操作起来比较方便，也容易控制添加量。当然，抗凝剂添加装置13也可以不与控制装置6连接，此时，可以采用手动控制抗凝剂的添加以及添加量。在具体应用中可以根据需要灵活选择，本发明对此不作限制。
参考图1-图4所示，本发明实施例提供的在体闭环灭菌设备，还包括压力传感器12。具体来说，可以在采血装置1和回输装置5的外部分别设置有压力传感器12。压力传感器12均通过通讯控制线与控制装置6连接。 而为了实现准确的压力检测，压力传感器12在设置时均要靠近相应的管路。
其中，设置在采血装置1外部的压力传感器12用于检测采血端，例如采血装置内采血管的压力情况，以及与采血装置1连接的第一管路8内的压力情况。同样的，设置在回输装置5外部的压力传感器12用于检测回输端，例如回输装置5内输血管道内的压力情况，以及与回输装置5连接的第二管路9和第四管路11内的压力情况。通过压力检测可以判断针(例如采血针、输血针)和相应的管路是否产生堵塞。一旦出现堵塞，很容易造成管内压力异常，引发危险。
需要说明的是，压力传感器12的设置位置有多种，并不限于上述实施例中的方式。例如：将压力传感器12分别设置在相应的管路上。或者是，将压力传感器12设置在相应的管路内部。可以根据实际情况灵活调整，本发明对此不作限制。另外，对于压力传感器12的设置数量本发明也不作具体限定，可以根据需要灵活选择合适的数量。
并且，每个压力传感器12均可以通过通信控制线与控制装置6连接。该设计可以实现控制装置6对压力传感器12的控制，即可以控制压力传感8在合适的时机启动压力检测，当然也可以控制压力传感器12不进行压力检测。
参考图1-图4所示，本发明实施例提供的在体闭环灭菌设备，还可以包括成分检测装置16。成分检测装置16可以通过检测线或者通讯控制线与细胞离心分离装置2连接，成分检测装置16还通过检测线或者通讯控制线与控制装置6连接。其中，成分检测装置16被配置为：在控制装置6的控制下检测经细胞离心分离装置2分离出的各部分的成分和纯度等，并且，该成分检测装置16还可以对细胞离心分离装置2的成分分离过程进行控制，以使不同的成分能形成良好的分层状态，有利于对不同的成分进行分别提取。也就是说，当细胞离心分离装置2将血液分成不同的成分时，通过成分检测装置16可以检测出各成分的分层状态、种类和纯度。需要说明的是，成分检测装置16可以根据需要选择设置或者不设置。
参考图1-图4所示，本发明实施例提供的在体闭环灭菌设备，还包括超声气泡传感器15，该超声气泡传感器15位于回输装置5所在的一端。 该超声气泡传感器15与回输装置5连接。具体来说，超声气泡传感器15是采用超声检测回输的血液中是否含有气泡，一旦检测到血液中含有气泡就要立即停止向体内回输血液并报警，否则血液进入身体中会发生危险。
并且，超声气泡传感器15还通过通讯控制线与控制装置6连接。该设计可以实现控制装置6对超声气泡传感器15的控制，即可以控制超声气泡传感器15在合适的时机启动检测，当然也可以控制超声气泡传感器15不进行检测。也就是说，通过控制装置6可以实现对超声气泡传感器15的自动化控制。
参考图1-图4所示，本发明实施例提供的在体闭环灭菌设备，还可以包括补液装置14。该补液装置14被配置为：在回输血液时，向血液中内进行补液，例如可以向体内补充营养液或药物等。其中，补液装置14可以通过补液管与回输装置5连接。当然，补液装置14也可以与回输装置5结合在一起。所述的两种方式均可以实现向回输的血液中添加营养液或药物。
并且，补液装置14可以通过通讯控制线与控制装置6连接。该设计可以实现控制装置6对补液装置14的控制，以实现补液的自动化。
需要说明的是，本发明中的抗凝剂添加装置13和补液装置14可以采用专用的泵，其运行或者停止可以由控制装置6进行控制。本发明中的压力传感器12、超声气泡传感器15、成分检测装置16也由控制装置6进行控制，实现了操作的自动化。
虽然已经通过例子对本发明的一些特定实施例进行了详细说明，但是本领域的技术人员应该理解，以上例子仅是为了进行说明，而不是为了限制本发明的范围。本领域的技术人员应该理解，可在不脱离本发明的范围和精神的情况下，对以上实施例进行修改。本发明的范围由所附权利要求来限定。

Claims (18)

  1. 一种在体闭环灭菌设备，其特征在于，包括采血装置、细胞离心分离装置、光照灭菌装置和回输装置；所述光照灭菌装置包括光照装置和待照射装置，所述待照射装置由透光材料制成；
    所述采血装置通过第一管路与所述细胞离心分离装置连接；
    所述细胞离心分离装置被配置为用于将血液分成非治疗部分和待治疗部分；所述细胞离心分离装置通过第二管路与所述回输装置连接；所述细胞离心分离装置还通过第三管路与所述待照射装置连接，所述待照射装置被配置为用于接收所述待治疗部分，所述光照装置被配置为用于对所述待照射装置内接收的待治疗部分进行光照射；
    所述待照射装置还通过第四管路与所述回输装置连接；
    还包括注药装置，所述注药装置与所述第三管路连接。
  2. 根据权利要求1所述的在体闭环灭菌设备，其特征在于，所述采血装置、细胞离心分离装置、光照装置、回输装置分别与控制装置连接。
  3. 根据权利要求1所述的在体闭环灭菌设备，其特征在于，还包括收集装置，所述收集装置连接在所述第三管路上；
    所述收集装置具有注入口，所述注入口与所述注药装置连接，所述收集装置被配置为：用于预先收集经所述细胞离心分离装置分离出的血液中的待治疗部分。
  4. 根据权利要求1所述的在体闭环灭菌设备，其特征在于，所述注药装置为注射器；或者是，
    所述注药装置为注药泵，所述注药泵与控制装置连接。
  5. 根据权利要求1所述的在体闭环灭菌设备，其特征在于，所述光照装置包括两个相对设置的灯板，所述两个灯板相对的两个面中至少有一个面上设置有多个照射光源；
    所述待照射装置设置在所述两个灯板之间。
  6. 根据权利要求5所述的在体闭环灭菌设备，其特征在于，所述待照射装置为血袋；
    还包括摆动机构，所述摆动机构由透光材料制成，所述血袋设置在所述摆动机构上；
    所述照射光源为灯珠或者灯管。
  7. 根据权利要求5所述的在体闭环灭菌设备，其特征在于，所述待照射装置为血液盒；
    所述血液盒包括扁平状的盒体，所述盒体内设置有透光的血液流道；
    所述照射光源为灯珠，多个灯珠在灯板上排列方式与所述血液流道的形状相匹配。
  8. 根据权利要求5所述的在体闭环灭菌设备，其特征在于，所述待照射装置为血液盒；
    所述血液盒包括扁平状的盒体，所述盒体上分别设置有进料口、出料口，所述盒体内设置有多个隔板，所述多个隔板将盒体内的空间分成多个容置腔，每个容置腔均设置有与所述进料口连通的进料分支口，每个容置腔还设置有与所述出料口连通的出料分支口；
    所述照射光源为灯珠，多个灯珠在灯板上呈多行多列排布，且相邻两行的灯珠呈相互错开设置；或者是，
    所述照射光源为灯管，多个灯管在灯板上依次排列，形成至少一排灯管。
  9. 根据权利要求5所述的在体闭环灭菌设备，其特征在于，所述待照射装置为输血管道，且所述输血管道伸入所述两个灯板之间的一段呈扁平状结构。
  10. 根据权利要求1所述的在体闭环灭菌设备，其特征在于，所述光照装置包括两端开口的圆筒状壳体，在所述圆筒状壳体的内壁上均匀设置有多个照射光源；
    所述待照射装置设置在所述圆筒状壳体的内部。
  11. 根据权利要求10所述的在体闭环灭菌设备，其特征在于，所述待照射装置为血液管路。
  12. 根据权利要求10所述的在体闭环灭菌设备，其特征在于，所述待照射装置为血液管路，所述血液管路其中一段的横截面尺寸大于该段两 端部的横截面尺寸，且在该段内设置有分流体，血液管路的内壁与分流体的外壁之间形成分流流道；
    所述分流体采用透光材料制成，所述分流体被配置为：当待治疗部分进入血液管路内，用于使待治疗部分沿着所述分流流道流过。
  13. 根据权利要求12所述的在体闭环灭菌设备，其特征在于，所述分流体为中空结构。
  14. 根据权利要求12所述的在体闭环灭菌设备，其特征在于，所述血液管路上设置有流量控制泵，所述流量控制泵与控制装置连接。
  15. 根据权利要求12所述的在体闭环灭菌设备，其特征在于，圆筒状壳体通过卡销或者合页安装在所述血液管路设置有所述分流体的一段上。
  16. 根据权利要求1所述的在体闭环灭菌设备，其特征在于，所述采血装置和所述回输装置的外部分别设置有压力传感器，所述压力传感器与控制装置连接。
  17. 根据权利要求1所述的在体闭环灭菌设备，其特征在于，所述细胞离心分离装置连接有成分检测装置，所述成分检测装置与控制装置连接，所述成分检测装置被配置为：在所述控制装置的控制下检测经所述细胞离心分离装置分离出的各部分的种类，纯度以及分层状态。
  18. 根据权利要求1所述的在体闭环灭菌设备，其特征在于，所述回输装置还分别连接超声气泡传感器、补液装置，所述超声气泡传感器、补液装置均与控制装置连接。
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