WO2020234498A3 - Terapia génica con los genes hokd y ldrb para el tratamiento del cáncer - Google Patents
Terapia génica con los genes hokd y ldrb para el tratamiento del cáncer Download PDFInfo
- Publication number
- WO2020234498A3 WO2020234498A3 PCT/ES2020/070315 ES2020070315W WO2020234498A3 WO 2020234498 A3 WO2020234498 A3 WO 2020234498A3 ES 2020070315 W ES2020070315 W ES 2020070315W WO 2020234498 A3 WO2020234498 A3 WO 2020234498A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- hokd
- ldrb
- gene therapy
- genes
- cancer treatments
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 title abstract 3
- 201000011510 cancer Diseases 0.000 title abstract 3
- 238000001415 gene therapy Methods 0.000 title abstract 2
- 238000011282 treatment Methods 0.000 title abstract 2
- 108090000623 proteins and genes Proteins 0.000 title 1
- 101100398795 Escherichia coli (strain K12) ldrB gene Proteins 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000002068 genetic effect Effects 0.000 abstract 1
- 101150033597 hokD gene Proteins 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 102000040430 polynucleotide Human genes 0.000 abstract 1
- 108091033319 polynucleotide Proteins 0.000 abstract 1
- 239000002157 polynucleotide Substances 0.000 abstract 1
- 230000002062 proliferating effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
- C07K14/245—Escherichia (G)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2207/00—Modified animals
- A01K2207/12—Animals modified by administration of exogenous cells
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/105—Murine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A01K2267/0331—Animal model for proliferative diseases
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Biotechnology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Zoology (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La invención descrita está relacionada con los polinucleótido de ARN o ADN aislados hokD y ldrB para uso en medicina, particularmente en terapia génica para el tratamiento del cáncer. También describe composiciones que comprenden tales polinucleótidos o construcciones genéticas relacionadas y un método de tratamiento de trastornos proliferativos, preferiblemente cáncer.
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP20810087.5A EP3984546A4 (en) | 2019-05-15 | 2020-05-15 | GENE THERAPY USING HOKD AND LDRB GENES FOR CANCER TREATMENT |
US17/611,460 US20220211872A1 (en) | 2019-05-15 | 2020-05-15 | Gene therapy with the genes hokd and ldrb for cancer treatments |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ESP201930428 | 2019-05-15 | ||
ESP201930427 | 2019-05-15 | ||
ES201930428 | 2019-05-15 | ||
ES201930427 | 2019-05-15 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2020234498A2 WO2020234498A2 (es) | 2020-11-26 |
WO2020234498A3 true WO2020234498A3 (es) | 2021-02-04 |
Family
ID=73459041
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/ES2020/070315 WO2020234498A2 (es) | 2019-05-15 | 2020-05-15 | Terapia génica con los genes hokd y ldrb para el tratamiento del cáncer |
Country Status (3)
Country | Link |
---|---|
US (1) | US20220211872A1 (es) |
EP (1) | EP3984546A4 (es) |
WO (1) | WO2020234498A2 (es) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2939632A1 (es) * | 2021-10-25 | 2023-04-25 | Univ Granada | Terapia génica con genes IdrB y HokD para el tratamiento del cáncer |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2002092825A2 (en) * | 2001-05-17 | 2002-11-21 | Aarhus Universitet | Retroviral vectors for gene therapy |
WO2013080147A2 (en) * | 2011-11-28 | 2013-06-06 | Adamed Sp. Z O.O. | Anticancer fusion protein |
WO2016185471A1 (en) * | 2015-05-17 | 2016-11-24 | The Medical Research, Infrastructure and Health Services Fund of the Tel Aviv Medical Center | Compositions and methods for treating cancer |
US20190153409A1 (en) * | 2017-11-17 | 2019-05-23 | Aviv MedTech Ltd. | Compositions comprising particles and methods for treating cancer |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US1685210A (en) | 1925-10-15 | 1928-09-25 | Niagara Electro Chemical Compa | Apparatus for electrically heating liquids |
HUE030881T2 (en) * | 2005-02-18 | 2017-06-28 | Glaxosmithkline Biologicals Sa | Meningitis / sepsis-associated escherichia coli proteins and nucleic acids |
-
2020
- 2020-05-15 WO PCT/ES2020/070315 patent/WO2020234498A2/es unknown
- 2020-05-15 US US17/611,460 patent/US20220211872A1/en active Pending
- 2020-05-15 EP EP20810087.5A patent/EP3984546A4/en active Pending
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2002092825A2 (en) * | 2001-05-17 | 2002-11-21 | Aarhus Universitet | Retroviral vectors for gene therapy |
WO2013080147A2 (en) * | 2011-11-28 | 2013-06-06 | Adamed Sp. Z O.O. | Anticancer fusion protein |
WO2016185471A1 (en) * | 2015-05-17 | 2016-11-24 | The Medical Research, Infrastructure and Health Services Fund of the Tel Aviv Medical Center | Compositions and methods for treating cancer |
US20190153409A1 (en) * | 2017-11-17 | 2019-05-23 | Aviv MedTech Ltd. | Compositions comprising particles and methods for treating cancer |
Non-Patent Citations (7)
Title |
---|
ALIX ERIC ET AL.: "Hydrophobic peptides: novel regulators within bacterial membrane.", MOLECULAR MICROBIOLOGY, vol. 72, no. 1, 31 March 2009 (2009-03-31), pages 5 - 11, XP055785543, ISSN: 1365-2958, DOI: 10.1111/j.1365-2958.2009.06626.x pubmed: 19210615 * |
ANONYMOUS: "Coding: ASE51079.1 Escherichia coli O157 small toxic polypeptide LdrB", EUROPEAN NUCLEOTIDE ARCHIVE , 29 June 2017 (2017-06-29), pages 1 - 2, XP009526309, Retrieved from the Internet <URL:https://www.ebi.ac.uk/ena/browser/view/ASE51079> [retrieved on 20201126] * |
ANONYMOUS: "Coding: ATG06226.1: Escherichia coli protein HokD", ENA, 2 October 2017 (2017-10-02), pages 1 - 2, XP009526312, Retrieved from the Internet <URL:https://www.ebi.ac.uk/ena/browser/view/ATG06226> [retrieved on 20201126] * |
KAWANO MITSUOKI ET AL.: "Molecular characterization of long direct repeat (LDR) sequences expressing a stable mRNA encoding for a 35- amino-acid cell -killing peptide and a cis-encoded small antisense RNA in Escherichia coli.", MOLECULAR MICROBIOLOGY, vol. 45, no. 2, July 2002 (2002-07-01), pages 333 - 349, XP055785547, ISSN: 0950-382X * |
KAWANO MITSUOKI: "Divergently overlapping cis-encoded antisense RNA regulating toxin-antitoxin systems from E-coli hok/sok, ldr/rdl, symE/symR", RNA BIOLOGY, vol. 9, no. 12, 2012, pages 1520 - 1527, XP055785539, ISSN: 1547-6286, DOI: 10.4161/rna.22757 * |
YAMAGUCHI YOSHIHIRO ET AL.: "Regulation of growth and death in Escherichia coli by toxin-antitoxin systems.", NATURE REVIEWS MICROBIOLOGY, vol. 9, no. 11, 2011, pages 779 - 790, XP055785540, ISSN: 1740-1526, DOI: 10.1038/nrmicro2651 * |
YAMAGUCHI YOSHIHIRO, TOKUNAGA NARUMI, INOUYE MASAYORI, PHADTARE SANGITA: "Characterization of LdrA (long direct repeat A) protein of Escherichia coli.", JOURNAL OF MOLECULAR MICROBIOLOGY AND BIOTECHNOLOGY, vol. 24, no. 2, 2014, pages 91 - 97, XP009526316, ISSN: 1660-2412, DOI: 10.1159/000357949 * |
Also Published As
Publication number | Publication date |
---|---|
EP3984546A4 (en) | 2023-09-27 |
WO2020234498A2 (es) | 2020-11-26 |
US20220211872A1 (en) | 2022-07-07 |
EP3984546A2 (en) | 2022-04-20 |
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